Motif 735 (n=219)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NCL7 | ANKRD33B | S45 | ochoa | Ankyrin repeat domain-containing protein 33B | None |
| A6NDU8 | RIMOC1 | S238 | ochoa | RAB7A-interacting MON1-CCZ1 complex subunit 1 (UPF0600 protein C5orf51) | Plays an important role in the removal of damaged mitochondria via mitophagy by controlling the stability and localization of RAB7A. Required for the recruitment of RAB7A and ATG9A vesicles to damaged mitochondria and promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy. {ECO:0000269|PubMed:34432599}. |
| A6NMY6 | ANXA2P2 | S164 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| A8MSY1 | STIMATE-MUSTN1 | S255 | ochoa | Musculoskeletal embryonic nuclear protein 1 | None |
| A8MTJ3 | GNAT3 | S47 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction (PubMed:38600377, PubMed:38776963). Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs such as TAS2R14 act as bitter sensors (PubMed:38600377, PubMed:38776963). Also functions as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. {ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:17724330, ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}. |
| H3BQZ7 | HNRNPUL2-BSCL2 | S224 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O00329 | PIK3CD | S520 | ochoa | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. {ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:20081091, ECO:0000269|PubMed:22020336, ECO:0000269|PubMed:9235916}. |
| O00566 | MPHOSPH10 | S139 | ochoa | U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}. |
| O14715 | RGPD8 | S1223 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14936 | CASK | S562 | ochoa | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) | Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:18423203}. |
| O14967 | CLGN | S576 | ochoa | Calmegin | Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). {ECO:0000250}. |
| O43719 | HTATSF1 | S597 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O60260 | PRKN | S378 | psp | E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2) | Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:29311685, PubMed:32047033). Substrates include SYT11 and VDAC1 (PubMed:29311685, PubMed:32047033). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25474007, PubMed:25621951, PubMed:32047033). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11431533, PubMed:11590439, PubMed:15105460, PubMed:15728840, PubMed:19229105). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:11439185, PubMed:18957282, PubMed:19029340, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24660806, PubMed:24784582, PubMed:24896179, PubMed:25474007, PubMed:25527291, PubMed:32047033). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:11439185, PubMed:19029340, PubMed:19801972, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291, PubMed:32047033, PubMed:33499712). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:24660806, PubMed:24784582, PubMed:25474007, PubMed:25527291). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:27534820, PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:21753002, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (PubMed:25621951, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:23620051). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:23620051). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed:21376232). Limits the production of reactive oxygen species (ROS) (PubMed:18541373). Regulates cyclin-E during neuronal apoptosis (PubMed:12628165). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (PubMed:12719539). {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:10973942, ECO:0000269|PubMed:11431533, ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:11590439, ECO:0000269|PubMed:12150907, ECO:0000269|PubMed:12628165, ECO:0000269|PubMed:12719539, ECO:0000269|PubMed:15105460, ECO:0000269|PubMed:15728840, ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19029340, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19801972, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23685073, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951, ECO:0000269|PubMed:27534820, ECO:0000269|PubMed:29311685, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:33499712}. |
| O60271 | SPAG9 | S388 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60664 | PLIN3 | S138 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O75128 | COBL | S574 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75153 | CLUH | S670 | ochoa | Clustered mitochondria protein homolog | mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. {ECO:0000255|HAMAP-Rule:MF_03013, ECO:0000269|PubMed:25349259}. |
| O75164 | KDM4A | S412 | ochoa | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. |
| O75410 | TACC1 | S315 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75807 | PPP1R15A | S421 | ochoa | Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog) | Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:26095357, PubMed:26742780). Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 (PubMed:14718519). May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15' (PubMed:14635196). Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). Also acts a viral restriction factor by attenuating HIV-1 replication (PubMed:31778897). Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation (PubMed:31778897). {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:26095357, ECO:0000269|PubMed:31778897, ECO:0000269|PubMed:8139541}.; FUNCTION: (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR. {ECO:0000269|PubMed:34985336}. |
| O75844 | ZMPSTE24 | S310 | ochoa | CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Prenyl protein-specific endoprotease 1) (Zinc metalloproteinase Ste24 homolog) | Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:33293369, PubMed:33315887). Proteolytically removes the C-terminal three residues of farnesylated proteins (PubMed:33293369, PubMed:33315887). Also plays an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia (PubMed:28169297, PubMed:28246125). Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:35283811). {ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:28246125, ECO:0000269|PubMed:33293369, ECO:0000269|PubMed:33315887, ECO:0000269|PubMed:35283811}. |
| O94880 | PHF14 | S92 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O94992 | HEXIM1 | S252 | psp | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| O95210 | STBD1 | S190 | ochoa | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95260 | ATE1 | S169 | ochoa | Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) | Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein (PubMed:34893540). This arginylation is required for degradation of the protein via the ubiquitin pathway (PubMed:34893540). Does not arginylate cysteine residues (By similarity). {ECO:0000250|UniProtKB:Q9Z2A5, ECO:0000269|PubMed:34893540}. |
| O95551 | TDP2 | S95 | ochoa | Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:27060144, PubMed:27099339). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. {ECO:0000269|PubMed:19794497, ECO:0000269|PubMed:21030584, ECO:0000269|PubMed:21921940, ECO:0000269|PubMed:21980489, ECO:0000269|PubMed:22405347, ECO:0000269|PubMed:22822062, ECO:0000269|PubMed:24658003, ECO:0000269|PubMed:27060144, ECO:0000269|PubMed:27099339}.; FUNCTION: (Microbial infection) Used by picornaviruses to remove the small polypeptide, VPg (virus Protein genome-linked, the primer for viral RNA synthesis), from the genomic RNA of the virus. Acts as a 5'-tyrosyl RNA phosphodiesterase and cleaves the covalent VPg-Tyr-RNA bond. This cleavage would play a role in viral replication and occur in viral replication vesicles, but would not act on viral mRNA. {ECO:0000269|PubMed:22908287, ECO:0000269|PubMed:32023921}. |
| O95810 | CAVIN2 | T199 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| O95810 | CAVIN2 | S361 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| O95835 | LATS1 | S1104 | ochoa | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P02748 | C9 | S261 | ochoa | Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b] | Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:26841934, PubMed:27052168, PubMed:30552328, PubMed:6177822, PubMed:9212048, PubMed:9634479). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:9212048, PubMed:9634479). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:9212048, PubMed:9634479). Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore (PubMed:26841934, PubMed:30111885, PubMed:30552328, PubMed:34752492, PubMed:4055801, PubMed:6177822). {ECO:0000269|PubMed:22832194, ECO:0000269|PubMed:26841837, ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:27052168, ECO:0000269|PubMed:30111885, ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:34752492, ECO:0000269|PubMed:4055801, ECO:0000269|PubMed:6177822, ECO:0000269|PubMed:9212048, ECO:0000269|PubMed:9634479}. |
| P04899 | GNAI2 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P05060 | CHGB | S317 | ochoa | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P07355 | ANXA2 | S164 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07900 | HSP90AA1 | S315 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08133 | ANXA6 | S494 | ochoa | Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) | May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. |
| P08172 | CHRM2 | S283 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| P08238 | HSP90AB1 | S307 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P08754 | GNAI3 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
| P09471 | GNAO1 | S47 | ochoa | Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:29925951, PubMed:33408414). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase (By similarity). Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). {ECO:0000250|UniProtKB:P18872, ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:33408414}. |
| P0DJD0 | RGPD1 | S1208 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1216 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P11488 | GNAT1 | S43 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) | Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). {ECO:0000250|UniProtKB:P04695, ECO:0000269|PubMed:22190596}. |
| P12883 | MYH7 | T1891 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | T1893 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P16150 | SPN | S363 | ochoa | Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)] | Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). {ECO:0000250|UniProtKB:P15702, ECO:0000269|PubMed:18036228, ECO:0000269|PubMed:24328034}.; FUNCTION: [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. {ECO:0000250|UniProtKB:P15702}. |
| P16284 | PECAM1 | S714 | ochoa | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. {ECO:0000269|PubMed:18388311}. |
| P16949 | STMN1 | S38 | ochoa|psp | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P16949 | STMN1 | S63 | ochoa|psp | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P17661 | DES | S298 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P19087 | GNAT2 | S47 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. |
| P20700 | LMNB1 | S284 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P23193 | TCEA1 | S110 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P23327 | HRC | S171 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P25054 | APC | S245 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27986 | PIK3R1 | S541 | psp | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}. |
| P28290 | ITPRID2 | S366 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29401 | TKT | S256 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P35579 | MYH9 | S1017 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1122 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35637 | FUS | S282 | ochoa | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P38405 | GNAL | S56 | ochoa | Guanine nucleotide-binding protein G(olf) subunit alpha (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein, olfactory type) | Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs) (By similarity). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (By similarity). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (By similarity). {ECO:0000250|UniProtKB:P38406, ECO:0000250|UniProtKB:Q8CGK7}. |
| P42345 | MTOR | S1418 | ochoa|psp | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) | Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}. |
| P46821 | MAP1B | S995 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S731 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49321 | NASP | S480 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49321 | NASP | S662 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49736 | MCM2 | S108 | ochoa|psp | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P49792 | RANBP2 | S2199 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50148 | GNAQ | S53 | psp | Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:37991948). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:37991948). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:37991948). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:37991948). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:37991948). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNAQ activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:37991948). Required for platelet activation (By similarity). Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity (By similarity). Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNA11, required for heart development (By similarity). {ECO:0000250|UniProtKB:P21279, ECO:0000269|PubMed:27852822, ECO:0000269|PubMed:37991948}. |
| P51659 | HSD17B4 | S294 | ochoa | Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| P52565 | ARHGDIA | S24 | ochoa | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
| P52739 | ZNF131 | S579 | ochoa | Zinc finger protein 131 | Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. {ECO:0000250, ECO:0000269|PubMed:18847501, ECO:0000269|PubMed:22467880}. |
| P54920 | NAPA | S160 | ochoa | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}. |
| P55081 | MFAP1 | S82 | ochoa | Microfibrillar-associated protein 1 (Spliceosome B complex protein MFAP1) | Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}. |
| P55081 | MFAP1 | S258 | ochoa | Microfibrillar-associated protein 1 (Spliceosome B complex protein MFAP1) | Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}. |
| P63096 | GNAI1 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883, PubMed:38918398). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:18434541, PubMed:8774883). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:18434541, PubMed:8774883). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:18434541, PubMed:8774883). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:8119955). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). {ECO:0000250|UniProtKB:P10824, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38552625, ECO:0000269|PubMed:38918398, ECO:0000269|PubMed:8119955, ECO:0000269|PubMed:8774883}. |
| P78347 | GTF2I | S19 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P78527 | PRKDC | S3432 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q01831 | XPC | S892 | psp | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q01995 | TAGLN | S85 | ochoa | Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha) | Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. {ECO:0000250}. |
| Q02818 | NUCB1 | S320 | ochoa | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q02880 | TOP2B | S1452 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q02952 | AKAP12 | S651 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S887 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03188 | CENPC | S687 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q07157 | TJP1 | S994 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q0VAQ4 | SMAGP | S77 | ochoa | Small cell adhesion glycoprotein (Small transmembrane and glycosylated protein) | May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation. {ECO:0000269|PubMed:15986429}. |
| Q12873 | CHD3 | S1251 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q12888 | TP53BP1 | S640 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S660 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13427 | PPIG | S397 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13501 | SQSTM1 | S328 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13813 | SPTAN1 | S1041 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q15047 | SETDB1 | S872 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15269 | PWP2 | S898 | ochoa | Periodic tryptophan protein 2 homolog | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q15291 | RBBP5 | S396 | ochoa | Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) | In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:Q8BX09, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| Q15643 | TRIP11 | S601 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q1KMD3 | HNRNPUL2 | S224 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q2KHR3 | QSER1 | S1348 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2M1K9 | ZNF423 | S47 | ochoa | Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein) | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269|PubMed:10660046}. |
| Q32P28 | P3H1 | S706 | ochoa | Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1) | Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. {ECO:0000269|PubMed:10951563}. |
| Q4LE39 | ARID4B | S1060 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q5H9R7 | PPP6R3 | S823 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5JWF2 | GNAS | S697 | ochoa | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas) | Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. {ECO:0000250|UniProtKB:Q6R0H7}. |
| Q5SNT2 | TMEM201 | S612 | ochoa | Transmembrane protein 201 (Spindle-associated membrane protein 1) | Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}. |
| Q5T0Z8 | C6orf132 | S722 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T200 | ZC3H13 | S1445 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T5Y3 | CAMSAP1 | S1229 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5UIP0 | RIF1 | S1384 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S2006 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5W0B1 | OBI1 | S115 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q658Y4 | FAM91A1 | S684 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q68D20 | PMS2CL | S159 | ochoa | Protein PMS2CL (PMS2-C terminal-like protein) | None |
| Q6IBW4 | NCAPH2 | S246 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6KC79 | NIPBL | S1197 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6PCB8 | EMB | S306 | ochoa | Embigin | Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane (By similarity). {ECO:0000250|UniProtKB:O88775}. |
| Q6PJP8 | DCLRE1A | S340 | ochoa | DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A) | May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269|PubMed:15542852}. |
| Q6VMQ6 | ATF7IP | S473 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q7L0J3 | SV2A | S80 | psp | Synaptic vesicle glycoprotein 2A | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO:0000250}.; FUNCTION: (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. {ECO:0000269|PubMed:29649119, ECO:0000305|PubMed:29649119}. |
| Q7L9L4 | MOB1B | S38 | ochoa | MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}. |
| Q7Z3J3 | RGPD4 | S1224 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z4V5 | HDGFL2 | S595 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z5K2 | WAPL | S445 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z6Z7 | HUWE1 | S2362 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86TL2 | STIMATE | S255 | ochoa | Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110) | Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574). {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}. |
| Q8IWP9 | CCDC28A | S255 | ochoa | Coiled-coil domain-containing protein 28A (CCRL1AP) | None |
| Q8IX03 | WWC1 | S834 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IZT6 | ASPM | S565 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N0X7 | SPART | S400 | ochoa | Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) | Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy (PubMed:37443287). Lipid transfer protein required for lipid droplet degradation, including by lipophagy (PubMed:38190532). Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown (PubMed:38190532). May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). {ECO:0000269|PubMed:20719964, ECO:0000269|PubMed:37443287, ECO:0000269|PubMed:38190532}. |
| Q8N1F7 | NUP93 | S165 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8NB91 | FANCB | S456 | ochoa | Fanconi anemia group B protein (Protein FACB) (Fanconi anemia-associated polypeptide of 95 kDa) (FAAP95) | DNA repair protein required for FANCD2 ubiquitination. {ECO:0000269|PubMed:15502827}. |
| Q8NFQ8 | TOR1AIP2 | S22 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8TAE8 | GADD45GIP1 | Y166 | ochoa | Large ribosomal subunit protein mL64 (39S ribosomal protein L59, mitochondrial) (MRP-L59) (CKII beta-associating protein) (CR6-interacting factor 1) (CRIF1) (Growth arrest and DNA damage-inducible proteins-interacting protein 1) (Papillomavirus L2-interacting nuclear protein 1) (PLINP) (PLINP-1) (p53-responsive gene 6 protein) | Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. |
| Q8TDJ6 | DMXL2 | S930 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TER5 | ARHGEF40 | S866 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8TEW0 | PARD3 | S958 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WU90 | ZC3H15 | S368 | ochoa | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
| Q8WZ42 | TTN | S4010 | psp | Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) | Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. {ECO:0000269|PubMed:11846417, ECO:0000269|PubMed:9804419}. |
| Q92576 | PHF3 | S299 | ochoa | PHD finger protein 3 | None |
| Q92613 | JADE3 | S674 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92766 | RREB1 | S1592 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q93045 | STMN2 | S97 | ochoa|psp | Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}. |
| Q96HW7 | INTS4 | S345 | ochoa | Integrator complex subunit 4 (Int4) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:29471365, PubMed:33243860, PubMed:33548203, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS4 acts as an scaffold that links INTS9 and INTS11 (PubMed:29471365, PubMed:33548203). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:29471365, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33548203, ECO:0000269|PubMed:38570683}. |
| Q96K49 | TMEM87B | S521 | ochoa | Transmembrane protein 87B | May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. |
| Q96K76 | USP47 | S910 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96QT4 | TRPM7 | S1271 | psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RL1 | UIMC1 | S27 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96RL1 | UIMC1 | S397 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96SN8 | CDK5RAP2 | S140 | psp | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q96SN8 | CDK5RAP2 | S256 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q96T88 | UHRF1 | S107 | ochoa | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q96TC7 | RMDN3 | S201 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q99442 | SEC62 | S353 | ochoa | Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) | Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. {ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q99590 | SCAF11 | S472 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99590 | SCAF11 | S694 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99661 | KIF2C | S629 | ochoa | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q99666 | RGPD5 | S1223 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BR77 | CCDC77 | S189 | ochoa | Coiled-coil domain-containing protein 77 | None |
| Q9BTC0 | DIDO1 | S203 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BUR4 | WRAP53 | S99 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BXP5 | SRRT | S579 | ochoa | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q9BXY0 | MAK16 | S229 | ochoa | Protein MAK16 homolog (NNP78) (Protein RBM13) | None |
| Q9BZD6 | PRRG4 | S38 | ochoa | Transmembrane gamma-carboxyglutamic acid protein 4 (Proline-rich gamma-carboxyglutamic acid protein 4) (Proline-rich Gla protein 4) | May control axon guidance across the CNS (PubMed:28859078). Prevents the delivery of ROBO1 at the cell surface and down-regulates its expression (PubMed:28859078). {ECO:0000269|PubMed:28859078}. |
| Q9C0C2 | TNKS1BP1 | S592 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0E9 | BRD8 | S637 | ochoa | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) | May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q9H115 | NAPB | S160 | ochoa | Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. {ECO:0000250|UniProtKB:P28663}. |
| Q9H2G2 | SLK | S372 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H4E7 | DEF6 | S387 | ochoa | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}. |
| Q9H4L7 | SMARCAD1 | S132 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H4L7 | SMARCAD1 | S242 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H582 | ZNF644 | S356 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H6Y2 | WDR55 | S21 | ochoa | WD repeat-containing protein 55 | Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}. |
| Q9H8M2 | BRD9 | S45 | ochoa | Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) | Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). {ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:32457312}. |
| Q9H8S9 | MOB1A | S38 | ochoa | MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}. |
| Q9NP61 | ARFGAP3 | S273 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NP74 | PALMD | S515 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
| Q9NQB0 | TCF7L2 | S32 | ochoa | Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) | Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}. |
| Q9NRY4 | ARHGAP35 | S970 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NWH9 | SLTM | S139 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NYL9 | TMOD3 | S125 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9NZB2 | FAM120A | S1041 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P212 | PLCE1 | S67 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182, ECO:0000269|PubMed:29058690}. |
| Q9P260 | RELCH | S1157 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9UBW5 | BIN2 | S91 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UKK3 | PARP4 | S1507 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UKW4 | VAV3 | S213 | ochoa | Guanine nucleotide exchange factor VAV3 (VAV-3) | Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). {ECO:0000250}. |
| Q9UKX2 | MYH2 | S1741 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T1897 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKY1 | ZHX1 | S635 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9UKY7 | CDV3 | S96 | ochoa | Protein CDV3 homolog | None |
| Q9UMZ2 | SYNRG | S809 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPS6 | SETD1B | S1275 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9UPW6 | SATB2 | S682 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
| Q9Y2F5 | ICE1 | S671 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y371 | SH3GLB1 | S190 | ochoa | Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1) | May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity). {ECO:0000250|UniProtKB:Q9JK48, ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144, ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21068542}. |
| Q9Y3T9 | NOC2L | S22 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y450 | HBS1L | S189 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y485 | DMXL1 | S422 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y496 | KIF3A | S383 | ochoa | Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) | Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. {ECO:0000250|UniProtKB:P28741}. |
| Q9Y4F5 | CEP170B | S930 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y6J0 | CABIN1 | S1442 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6J0 | CABIN1 | S2067 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6X4 | FAM169A | S449 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
| O00410 | IPO5 | S974 | Sugiyama | Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000250|UniProtKB:Q8BKC5, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9687515}. |
| Q6ULP2 | AFTPH | S328 | Sugiyama | Aftiphilin | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
| Q12888 | TP53BP1 | S197 | Sugiyama | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q8NBS9 | TXNDC5 | S292 | Sugiyama | Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46) | Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds. {ECO:0000250|UniProtKB:Q91W90}. |
| P06493 | CDK1 | S46 | Sugiyama | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}. |
| P51957 | NEK4 | S631 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| Q96ES7 | SGF29 | S31 | Sugiyama | SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29) | Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity). {ECO:0000250|UniProtKB:Q9DA08, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21685874, ECO:0000269|PubMed:23894581, ECO:0000269|PubMed:26421618, ECO:0000269|PubMed:26578293}. |
| Q9BRK5 | SDF4 | S343 | Sugiyama | 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. |
| Q14164 | IKBKE | S151 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| Q13451 | FKBP5 | S27 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:26101251, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:28363942, ECO:0000269|PubMed:31434731}. |
| Q99700 | ATXN2 | S451 | Sugiyama | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| P14618 | PKM | S67 | Sugiyama | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| Q9UQ80 | PA2G4 | S41 | Sugiyama | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| Q9BYP7 | WNK3 | S422 | Sugiyama | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
| Q9P0L2 | MARK1 | S383 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9UHD2 | TBK1 | S151 | Sugiyama | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.000010 | 4.999 |
| R-HSA-2028269 | Signaling by Hippo | 0.000020 | 4.696 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.000140 | 3.854 |
| R-HSA-9634597 | GPER1 signaling | 0.000188 | 3.726 |
| R-HSA-392518 | Signal amplification | 0.000363 | 3.441 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.000312 | 3.505 |
| R-HSA-418597 | G alpha (z) signalling events | 0.000351 | 3.455 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.000590 | 3.229 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.000606 | 3.217 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.000567 | 3.246 |
| R-HSA-991365 | Activation of GABAB receptors | 0.000881 | 3.055 |
| R-HSA-977444 | GABA B receptor activation | 0.000881 | 3.055 |
| R-HSA-112040 | G-protein mediated events | 0.000865 | 3.063 |
| R-HSA-1640170 | Cell Cycle | 0.001017 | 2.993 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.001434 | 2.844 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.001448 | 2.839 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.001434 | 2.844 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.001360 | 2.866 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.001935 | 2.713 |
| R-HSA-4839726 | Chromatin organization | 0.002091 | 2.680 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.002417 | 2.617 |
| R-HSA-390522 | Striated Muscle Contraction | 0.002902 | 2.537 |
| R-HSA-977443 | GABA receptor activation | 0.003327 | 2.478 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.003692 | 2.433 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.004063 | 2.391 |
| R-HSA-162582 | Signal Transduction | 0.004092 | 2.388 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.004280 | 2.369 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.004749 | 2.323 |
| R-HSA-9658195 | Leishmania infection | 0.004838 | 2.315 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.004838 | 2.315 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.005613 | 2.251 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.005504 | 2.259 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.006182 | 2.209 |
| R-HSA-373753 | Nephrin family interactions | 0.005972 | 2.224 |
| R-HSA-111885 | Opioid Signalling | 0.007009 | 2.154 |
| R-HSA-75153 | Apoptotic execution phase | 0.008248 | 2.084 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.009478 | 2.023 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.009478 | 2.023 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.008937 | 2.049 |
| R-HSA-9927354 | Co-stimulation by ICOS | 0.011360 | 1.945 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.011360 | 1.945 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.013667 | 1.864 |
| R-HSA-68877 | Mitotic Prometaphase | 0.012821 | 1.892 |
| R-HSA-176974 | Unwinding of DNA | 0.013393 | 1.873 |
| R-HSA-9663891 | Selective autophagy | 0.014082 | 1.851 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.012628 | 1.899 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.013393 | 1.873 |
| R-HSA-8939211 | ESR-mediated signaling | 0.013360 | 1.874 |
| R-HSA-9612973 | Autophagy | 0.014150 | 1.849 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.014366 | 1.843 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.014510 | 1.838 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.015330 | 1.814 |
| R-HSA-68886 | M Phase | 0.015297 | 1.815 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.015570 | 1.808 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.023701 | 1.625 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.019578 | 1.708 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.023701 | 1.625 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.023701 | 1.625 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.022930 | 1.640 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.020523 | 1.688 |
| R-HSA-192905 | vRNP Assembly | 0.017889 | 1.747 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.020343 | 1.692 |
| R-HSA-5205647 | Mitophagy | 0.022279 | 1.652 |
| R-HSA-422356 | Regulation of insulin secretion | 0.022008 | 1.657 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.023334 | 1.632 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.020343 | 1.692 |
| R-HSA-68882 | Mitotic Anaphase | 0.022664 | 1.645 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.023164 | 1.635 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.020996 | 1.678 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.022769 | 1.643 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.022769 | 1.643 |
| R-HSA-373755 | Semaphorin interactions | 0.020428 | 1.690 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.022332 | 1.651 |
| R-HSA-163685 | Integration of energy metabolism | 0.024931 | 1.603 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 0.028526 | 1.545 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.025644 | 1.591 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.028257 | 1.549 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.028532 | 1.545 |
| R-HSA-1632852 | Macroautophagy | 0.028532 | 1.545 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.028630 | 1.543 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.029872 | 1.525 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.030063 | 1.522 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.031439 | 1.503 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.031439 | 1.503 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.031535 | 1.501 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.033245 | 1.478 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.035002 | 1.456 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.034511 | 1.462 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.034708 | 1.460 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 0.042483 | 1.372 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.042483 | 1.372 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.056241 | 1.250 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.056241 | 1.250 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.056241 | 1.250 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.056241 | 1.250 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.056241 | 1.250 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.056241 | 1.250 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.056241 | 1.250 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.056241 | 1.250 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.056241 | 1.250 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.056241 | 1.250 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.056241 | 1.250 |
| R-HSA-209563 | Axonal growth stimulation | 0.069802 | 1.156 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.069802 | 1.156 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.069802 | 1.156 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.083169 | 1.080 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.096345 | 1.016 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.122133 | 0.913 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.122133 | 0.913 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.134751 | 0.870 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.134751 | 0.870 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.134751 | 0.870 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.040987 | 1.387 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.040987 | 1.387 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.147189 | 0.832 |
| R-HSA-9613354 | Lipophagy | 0.159448 | 0.797 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.055157 | 1.258 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.055157 | 1.258 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.171532 | 0.766 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.171532 | 0.766 |
| R-HSA-210990 | PECAM1 interactions | 0.183443 | 0.736 |
| R-HSA-4839744 | Signaling by APC mutants | 0.183443 | 0.736 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.183443 | 0.736 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.183443 | 0.736 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.183443 | 0.736 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 0.195184 | 0.710 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.195184 | 0.710 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.206756 | 0.685 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.206756 | 0.685 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.206756 | 0.685 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.206756 | 0.685 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.206756 | 0.685 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.206756 | 0.685 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.218163 | 0.661 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.218163 | 0.661 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.042501 | 1.372 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.096440 | 1.016 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.100945 | 0.996 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.100945 | 0.996 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.240489 | 0.619 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.240489 | 0.619 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.240489 | 0.619 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.240489 | 0.619 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.110123 | 0.958 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.110123 | 0.958 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.114792 | 0.940 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.143772 | 0.842 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.048814 | 1.311 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.048814 | 1.311 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.148742 | 0.828 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.084989 | 1.071 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.084989 | 1.071 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.093340 | 1.030 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.114057 | 0.943 |
| R-HSA-380287 | Centrosome maturation | 0.120271 | 0.920 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.166918 | 0.777 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.247649 | 0.606 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.210385 | 0.677 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.079048 | 1.102 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.099088 | 1.004 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.197634 | 0.704 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.096440 | 1.016 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.173971 | 0.760 |
| R-HSA-166665 | Terminal pathway of complement | 0.109332 | 0.961 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.087613 | 1.057 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.184386 | 0.734 |
| R-HSA-6798695 | Neutrophil degranulation | 0.089509 | 1.048 |
| R-HSA-191650 | Regulation of gap junction activity | 0.083169 | 1.080 |
| R-HSA-4641265 | Repression of WNT target genes | 0.206756 | 0.685 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.096345 | 1.016 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.134751 | 0.870 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.114792 | 0.940 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.251412 | 0.600 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.179216 | 0.747 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.071202 | 1.148 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.145467 | 0.837 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.148742 | 0.828 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.148742 | 0.828 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.105506 | 0.977 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.119511 | 0.923 |
| R-HSA-72172 | mRNA Splicing | 0.225788 | 0.646 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.079048 | 1.102 |
| R-HSA-5250992 | Toxicity of botulinum toxin type E (botE) | 0.109332 | 0.961 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.109332 | 0.961 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 0.122133 | 0.913 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 0.122133 | 0.913 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.047879 | 1.320 |
| R-HSA-5250968 | Toxicity of botulinum toxin type A (botA) | 0.159448 | 0.797 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.225398 | 0.647 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.127269 | 0.895 |
| R-HSA-5620924 | Intraflagellar transport | 0.194790 | 0.710 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.078987 | 1.102 |
| R-HSA-68875 | Mitotic Prophase | 0.046579 | 1.332 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.069802 | 1.156 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.083169 | 1.080 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.109332 | 0.961 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.044383 | 1.353 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.044383 | 1.353 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.159448 | 0.797 |
| R-HSA-5689877 | Josephin domain DUBs | 0.171532 | 0.766 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.195184 | 0.710 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.195184 | 0.710 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.195184 | 0.710 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.079048 | 1.102 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.206756 | 0.685 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.096440 | 1.016 |
| R-HSA-2485179 | Activation of the phototransduction cascade | 0.251412 | 0.600 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.251412 | 0.600 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.133944 | 0.873 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.163851 | 0.786 |
| R-HSA-69275 | G2/M Transition | 0.079265 | 1.101 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.082125 | 1.086 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.091995 | 1.036 |
| R-HSA-2424491 | DAP12 signaling | 0.096440 | 1.016 |
| R-HSA-9646399 | Aggrephagy | 0.148742 | 0.828 |
| R-HSA-418555 | G alpha (s) signalling events | 0.059648 | 1.224 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.240489 | 0.619 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.074385 | 1.129 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.037695 | 1.424 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.044383 | 1.353 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.159951 | 0.796 |
| R-HSA-418594 | G alpha (i) signalling events | 0.048725 | 1.312 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.206756 | 0.685 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.047879 | 1.320 |
| R-HSA-3371511 | HSF1 activation | 0.129089 | 0.889 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.104975 | 0.979 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.149677 | 0.825 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.194199 | 0.712 |
| R-HSA-9664407 | Parasite infection | 0.194199 | 0.712 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.194199 | 0.712 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 0.096345 | 1.016 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.134751 | 0.870 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.134751 | 0.870 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.044383 | 1.353 |
| R-HSA-198203 | PI3K/AKT activation | 0.171532 | 0.766 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.044492 | 1.352 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.114792 | 0.940 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.231690 | 0.635 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.133944 | 0.873 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.055123 | 1.259 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.096196 | 1.017 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.126224 | 0.899 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.040744 | 1.390 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.129089 | 0.889 |
| R-HSA-983189 | Kinesins | 0.258311 | 0.588 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.240610 | 0.619 |
| R-HSA-194138 | Signaling by VEGF | 0.054205 | 1.266 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.042483 | 1.372 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.147189 | 0.832 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.055157 | 1.258 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.183443 | 0.736 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.195184 | 0.710 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.179216 | 0.747 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.065434 | 1.184 |
| R-HSA-1221632 | Meiotic synapsis | 0.221087 | 0.655 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.252979 | 0.597 |
| R-HSA-191859 | snRNP Assembly | 0.252979 | 0.597 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.104975 | 0.979 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.047879 | 1.320 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.041605 | 1.381 |
| R-HSA-9664873 | Pexophagy | 0.171532 | 0.766 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.046528 | 1.332 |
| R-HSA-5617833 | Cilium Assembly | 0.187716 | 0.726 |
| R-HSA-4086398 | Ca2+ pathway | 0.114057 | 0.943 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.159448 | 0.797 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.058933 | 1.230 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.229406 | 0.639 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.240489 | 0.619 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.240489 | 0.619 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.119511 | 0.923 |
| R-HSA-180786 | Extension of Telomeres | 0.252979 | 0.597 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.039448 | 1.404 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.258311 | 0.588 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.093266 | 1.030 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.203027 | 0.692 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.258311 | 0.588 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.077002 | 1.113 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.157060 | 0.804 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.122133 | 0.913 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.122133 | 0.913 |
| R-HSA-1462054 | Alpha-defensins | 0.147189 | 0.832 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.159448 | 0.797 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.171532 | 0.766 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.058933 | 1.230 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.195184 | 0.710 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.195184 | 0.710 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.240489 | 0.619 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.129089 | 0.889 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.143772 | 0.842 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.148742 | 0.828 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.153747 | 0.813 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.117148 | 0.931 |
| R-HSA-69481 | G2/M Checkpoints | 0.056898 | 1.245 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.215800 | 0.666 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.067465 | 1.171 |
| R-HSA-2172127 | DAP12 interactions | 0.174069 | 0.759 |
| R-HSA-199991 | Membrane Trafficking | 0.174735 | 0.758 |
| R-HSA-3371556 | Cellular response to heat stress | 0.047802 | 1.321 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.074871 | 1.126 |
| R-HSA-418346 | Platelet homeostasis | 0.244441 | 0.612 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.110123 | 0.958 |
| R-HSA-5635838 | Activation of SMO | 0.251412 | 0.600 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.119511 | 0.923 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.242530 | 0.615 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.218163 | 0.661 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.229406 | 0.639 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.229406 | 0.639 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.082280 | 1.085 |
| R-HSA-3371568 | Attenuation phase | 0.148742 | 0.828 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.100200 | 0.999 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.252979 | 0.597 |
| R-HSA-3214847 | HATs acetylate histones | 0.214118 | 0.669 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.057383 | 1.241 |
| R-HSA-73894 | DNA Repair | 0.051535 | 1.288 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.110123 | 0.958 |
| R-HSA-162587 | HIV Life Cycle | 0.248761 | 0.604 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.104975 | 0.979 |
| R-HSA-168249 | Innate Immune System | 0.236355 | 0.626 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.217990 | 0.662 |
| R-HSA-69206 | G1/S Transition | 0.146765 | 0.833 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.114057 | 0.943 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.066742 | 1.176 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.218163 | 0.661 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.143772 | 0.842 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.136331 | 0.865 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.091995 | 1.036 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.048610 | 1.313 |
| R-HSA-9659379 | Sensory processing of sound | 0.133062 | 0.876 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.070784 | 1.150 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.109332 | 0.961 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.062796 | 1.202 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.133944 | 0.873 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.099088 | 1.004 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.221087 | 0.655 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.237003 | 0.625 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.138839 | 0.857 |
| R-HSA-109582 | Hemostasis | 0.191911 | 0.717 |
| R-HSA-73887 | Death Receptor Signaling | 0.040383 | 1.394 |
| R-HSA-69190 | DNA strand elongation | 0.105506 | 0.977 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.163851 | 0.786 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.163851 | 0.786 |
| R-HSA-70171 | Glycolysis | 0.078987 | 1.102 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.230180 | 0.638 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.081835 | 1.087 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.091995 | 1.036 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.066848 | 1.175 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.214978 | 0.668 |
| R-HSA-168255 | Influenza Infection | 0.161446 | 0.792 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.159448 | 0.797 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.183443 | 0.736 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.218163 | 0.661 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.251412 | 0.600 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.095763 | 1.019 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.147189 | 0.832 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.159448 | 0.797 |
| R-HSA-9842663 | Signaling by LTK | 0.206756 | 0.685 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.206668 | 0.685 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.095763 | 1.019 |
| R-HSA-397014 | Muscle contraction | 0.122585 | 0.912 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.096440 | 1.016 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.168947 | 0.772 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.098722 | 1.006 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.053765 | 1.270 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.079048 | 1.102 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.100945 | 0.996 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.117148 | 0.931 |
| R-HSA-70326 | Glucose metabolism | 0.123755 | 0.907 |
| R-HSA-1538133 | G0 and Early G1 | 0.105506 | 0.977 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.129089 | 0.889 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.057383 | 1.241 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.129089 | 0.889 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.122585 | 0.912 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.221087 | 0.655 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.217864 | 0.662 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.258173 | 0.588 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.148742 | 0.828 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.143772 | 0.842 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.239428 | 0.621 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.231690 | 0.635 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.168829 | 0.773 |
| R-HSA-75893 | TNF signaling | 0.237003 | 0.625 |
| R-HSA-211000 | Gene Silencing by RNA | 0.248281 | 0.605 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.184386 | 0.734 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.183443 | 0.736 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.242324 | 0.616 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.133782 | 0.874 |
| R-HSA-5357801 | Programmed Cell Death | 0.046853 | 1.329 |
| R-HSA-9679506 | SARS-CoV Infections | 0.215346 | 0.667 |
| R-HSA-8853659 | RET signaling | 0.129089 | 0.889 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.244441 | 0.612 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.185497 | 0.732 |
| R-HSA-109581 | Apoptosis | 0.122096 | 0.913 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.051962 | 1.284 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.148742 | 0.828 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.259856 | 0.585 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.259856 | 0.585 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.262180 | 0.581 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.262180 | 0.581 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.262180 | 0.581 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.262180 | 0.581 |
| R-HSA-388396 | GPCR downstream signalling | 0.263414 | 0.579 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.263645 | 0.579 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.263645 | 0.579 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.267611 | 0.572 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.268980 | 0.570 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.268980 | 0.570 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.268980 | 0.570 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.272793 | 0.564 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.272793 | 0.564 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.274314 | 0.562 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.279295 | 0.554 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.283253 | 0.548 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.283253 | 0.548 |
| R-HSA-180292 | GAB1 signalosome | 0.283253 | 0.548 |
| R-HSA-210993 | Tie2 Signaling | 0.283253 | 0.548 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.290300 | 0.537 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.293565 | 0.532 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.293565 | 0.532 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.293565 | 0.532 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.293565 | 0.532 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.293565 | 0.532 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.293565 | 0.532 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.293565 | 0.532 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.298866 | 0.525 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.300936 | 0.522 |
| R-HSA-5218859 | Regulated Necrosis | 0.300936 | 0.522 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.303728 | 0.518 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.303728 | 0.518 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.303728 | 0.518 |
| R-HSA-9629569 | Protein hydroxylation | 0.303728 | 0.518 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.306244 | 0.514 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.309368 | 0.510 |
| R-HSA-73886 | Chromosome Maintenance | 0.310648 | 0.508 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.311545 | 0.506 |
| R-HSA-202040 | G-protein activation | 0.313746 | 0.503 |
| R-HSA-210991 | Basigin interactions | 0.313746 | 0.503 |
| R-HSA-195721 | Signaling by WNT | 0.313761 | 0.503 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.315082 | 0.502 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.322120 | 0.492 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.322120 | 0.492 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.322444 | 0.492 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.323620 | 0.490 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.323620 | 0.490 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.327393 | 0.485 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.327393 | 0.485 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.327393 | 0.485 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.333353 | 0.477 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.333353 | 0.477 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 0.333353 | 0.477 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.333353 | 0.477 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.333353 | 0.477 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.333353 | 0.477 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.333353 | 0.477 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.333353 | 0.477 |
| R-HSA-449147 | Signaling by Interleukins | 0.334215 | 0.476 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.335368 | 0.474 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.337906 | 0.471 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.337906 | 0.471 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.342946 | 0.465 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.342946 | 0.465 |
| R-HSA-3000170 | Syndecan interactions | 0.342946 | 0.465 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.342946 | 0.465 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.352402 | 0.453 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 0.352402 | 0.453 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.352402 | 0.453 |
| R-HSA-429947 | Deadenylation of mRNA | 0.352402 | 0.453 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.352402 | 0.453 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.352402 | 0.453 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.352402 | 0.453 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.353579 | 0.452 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.361723 | 0.442 |
| R-HSA-420029 | Tight junction interactions | 0.361723 | 0.442 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.361723 | 0.442 |
| R-HSA-3214842 | HDMs demethylate histones | 0.361723 | 0.442 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 0.361723 | 0.442 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.361723 | 0.442 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.361723 | 0.442 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.361723 | 0.442 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.361723 | 0.442 |
| R-HSA-9833482 | PKR-mediated signaling | 0.363956 | 0.439 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.364723 | 0.438 |
| R-HSA-5688426 | Deubiquitination | 0.367034 | 0.435 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.369122 | 0.433 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.369885 | 0.432 |
| R-HSA-525793 | Myogenesis | 0.370909 | 0.431 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.370909 | 0.431 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.370909 | 0.431 |
| R-HSA-3295583 | TRP channels | 0.370909 | 0.431 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.370909 | 0.431 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.374270 | 0.427 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.377468 | 0.423 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.379965 | 0.420 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.379965 | 0.420 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.379965 | 0.420 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.379965 | 0.420 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.379965 | 0.420 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.379965 | 0.420 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.379965 | 0.420 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.379965 | 0.420 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.379965 | 0.420 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.381259 | 0.419 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.388890 | 0.410 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.388890 | 0.410 |
| R-HSA-622312 | Inflammasomes | 0.388890 | 0.410 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.388890 | 0.410 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.389038 | 0.410 |
| R-HSA-597592 | Post-translational protein modification | 0.389101 | 0.410 |
| R-HSA-1500620 | Meiosis | 0.389613 | 0.409 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.389613 | 0.409 |
| R-HSA-372790 | Signaling by GPCR | 0.393509 | 0.405 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.397687 | 0.400 |
| R-HSA-5334118 | DNA methylation | 0.397687 | 0.400 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.397687 | 0.400 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.404786 | 0.393 |
| R-HSA-70268 | Pyruvate metabolism | 0.404786 | 0.393 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.406359 | 0.391 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.406359 | 0.391 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.406359 | 0.391 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.406359 | 0.391 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.406359 | 0.391 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.406359 | 0.391 |
| R-HSA-186763 | Downstream signal transduction | 0.414906 | 0.382 |
| R-HSA-168256 | Immune System | 0.418318 | 0.378 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.419779 | 0.377 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.424734 | 0.372 |
| R-HSA-5663205 | Infectious disease | 0.427783 | 0.369 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.431334 | 0.365 |
| R-HSA-69242 | S Phase | 0.431334 | 0.365 |
| R-HSA-9930044 | Nuclear RNA decay | 0.431634 | 0.365 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.431634 | 0.365 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.431634 | 0.365 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.431634 | 0.365 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.434577 | 0.362 |
| R-HSA-391251 | Protein folding | 0.434577 | 0.362 |
| R-HSA-2262752 | Cellular responses to stress | 0.435437 | 0.361 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.435963 | 0.361 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.438917 | 0.358 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.439465 | 0.357 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.439465 | 0.357 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.439818 | 0.357 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.439818 | 0.357 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.439818 | 0.357 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.439818 | 0.357 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.444330 | 0.352 |
| R-HSA-203615 | eNOS activation | 0.447886 | 0.349 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.447886 | 0.349 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.447886 | 0.349 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.453967 | 0.343 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.455837 | 0.341 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.455837 | 0.341 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.455837 | 0.341 |
| R-HSA-157579 | Telomere Maintenance | 0.463553 | 0.334 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.463675 | 0.334 |
| R-HSA-163560 | Triglyceride catabolism | 0.463675 | 0.334 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.463675 | 0.334 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 0.471400 | 0.327 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.476221 | 0.322 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.477062 | 0.321 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.479014 | 0.320 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 0.479014 | 0.320 |
| R-HSA-162906 | HIV Infection | 0.480179 | 0.319 |
| R-HSA-71336 | Pentose phosphate pathway | 0.486519 | 0.313 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.486519 | 0.313 |
| R-HSA-201556 | Signaling by ALK | 0.486519 | 0.313 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.487025 | 0.312 |
| R-HSA-1483255 | PI Metabolism | 0.487025 | 0.312 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.493917 | 0.306 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.493917 | 0.306 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.493917 | 0.306 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.493917 | 0.306 |
| R-HSA-167169 | HIV Transcription Elongation | 0.493917 | 0.306 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.493917 | 0.306 |
| R-HSA-5260271 | Diseases of Immune System | 0.493917 | 0.306 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.501208 | 0.300 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.501208 | 0.300 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.501208 | 0.300 |
| R-HSA-9607240 | FLT3 Signaling | 0.501208 | 0.300 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.505338 | 0.296 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.508395 | 0.294 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.508395 | 0.294 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.508395 | 0.294 |
| R-HSA-69239 | Synthesis of DNA | 0.514335 | 0.289 |
| R-HSA-165159 | MTOR signalling | 0.515478 | 0.288 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.515478 | 0.288 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.518792 | 0.285 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.520685 | 0.283 |
| R-HSA-1461973 | Defensins | 0.522460 | 0.282 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.522460 | 0.282 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.522460 | 0.282 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.523223 | 0.281 |
| R-HSA-5683826 | Surfactant metabolism | 0.529342 | 0.276 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.529342 | 0.276 |
| R-HSA-6803157 | Antimicrobial peptides | 0.532003 | 0.274 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.536125 | 0.271 |
| R-HSA-774815 | Nucleosome assembly | 0.536125 | 0.271 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.536125 | 0.271 |
| R-HSA-1500931 | Cell-Cell communication | 0.536552 | 0.270 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.542811 | 0.265 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.542811 | 0.265 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.542811 | 0.265 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.542811 | 0.265 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.542811 | 0.265 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.544964 | 0.264 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.547034 | 0.262 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.549401 | 0.260 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 0.549401 | 0.260 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.562298 | 0.250 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.566008 | 0.247 |
| R-HSA-109704 | PI3K Cascade | 0.568608 | 0.245 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.568608 | 0.245 |
| R-HSA-9748787 | Azathioprine ADME | 0.568608 | 0.245 |
| R-HSA-5693538 | Homology Directed Repair | 0.570133 | 0.244 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.574228 | 0.241 |
| R-HSA-2514856 | The phototransduction cascade | 0.574827 | 0.240 |
| R-HSA-422475 | Axon guidance | 0.576088 | 0.240 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.580957 | 0.236 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.580957 | 0.236 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.580957 | 0.236 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.580957 | 0.236 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.580957 | 0.236 |
| R-HSA-8953854 | Metabolism of RNA | 0.585930 | 0.232 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.586902 | 0.231 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.587000 | 0.231 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.587000 | 0.231 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.587000 | 0.231 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.590328 | 0.229 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.590328 | 0.229 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.590328 | 0.229 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.598825 | 0.223 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.600460 | 0.222 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.604610 | 0.219 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.604610 | 0.219 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.604610 | 0.219 |
| R-HSA-177929 | Signaling by EGFR | 0.604610 | 0.219 |
| R-HSA-114608 | Platelet degranulation | 0.609813 | 0.215 |
| R-HSA-112399 | IRS-mediated signalling | 0.610313 | 0.214 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.615934 | 0.210 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.615934 | 0.210 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.621163 | 0.207 |
| R-HSA-9033241 | Peroxisomal protein import | 0.621473 | 0.207 |
| R-HSA-8979227 | Triglyceride metabolism | 0.621473 | 0.207 |
| R-HSA-1474165 | Reproduction | 0.624890 | 0.204 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.626934 | 0.203 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.626934 | 0.203 |
| R-HSA-9843745 | Adipogenesis | 0.628588 | 0.202 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.632316 | 0.199 |
| R-HSA-112043 | PLC beta mediated events | 0.632316 | 0.199 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.635900 | 0.197 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.637620 | 0.195 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.637620 | 0.195 |
| R-HSA-9707616 | Heme signaling | 0.637620 | 0.195 |
| R-HSA-186797 | Signaling by PDGF | 0.637620 | 0.195 |
| R-HSA-8848021 | Signaling by PTK6 | 0.642849 | 0.192 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.642849 | 0.192 |
| R-HSA-9675108 | Nervous system development | 0.647027 | 0.189 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.648002 | 0.188 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.648002 | 0.188 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.648002 | 0.188 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.650185 | 0.187 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.653081 | 0.185 |
| R-HSA-6807070 | PTEN Regulation | 0.660606 | 0.180 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.663022 | 0.178 |
| R-HSA-196807 | Nicotinate metabolism | 0.663022 | 0.178 |
| R-HSA-167172 | Transcription of the HIV genome | 0.667885 | 0.175 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.667885 | 0.175 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.669916 | 0.174 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.677403 | 0.169 |
| R-HSA-392499 | Metabolism of proteins | 0.680950 | 0.167 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.682060 | 0.166 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.682060 | 0.166 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.682060 | 0.166 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.682060 | 0.166 |
| R-HSA-8978934 | Metabolism of cofactors | 0.682060 | 0.166 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.682060 | 0.166 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.682060 | 0.166 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.686650 | 0.163 |
| R-HSA-9824446 | Viral Infection Pathways | 0.695282 | 0.158 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.695632 | 0.158 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.695632 | 0.158 |
| R-HSA-913531 | Interferon Signaling | 0.697049 | 0.157 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.700027 | 0.155 |
| R-HSA-8852135 | Protein ubiquitination | 0.700027 | 0.155 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.704358 | 0.152 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.705978 | 0.151 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.705978 | 0.151 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.707316 | 0.150 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.708627 | 0.150 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.708627 | 0.150 |
| R-HSA-69306 | DNA Replication | 0.709018 | 0.149 |
| R-HSA-112316 | Neuronal System | 0.712833 | 0.147 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.712835 | 0.147 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.712835 | 0.147 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.712835 | 0.147 |
| R-HSA-216083 | Integrin cell surface interactions | 0.712835 | 0.147 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.720023 | 0.143 |
| R-HSA-9610379 | HCMV Late Events | 0.720918 | 0.142 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.721070 | 0.142 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.721070 | 0.142 |
| R-HSA-6806834 | Signaling by MET | 0.721070 | 0.142 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.723828 | 0.140 |
| R-HSA-977225 | Amyloid fiber formation | 0.725099 | 0.140 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.736841 | 0.133 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.736841 | 0.133 |
| R-HSA-74160 | Gene expression (Transcription) | 0.739320 | 0.131 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.740643 | 0.130 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.748084 | 0.126 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.748084 | 0.126 |
| R-HSA-5619102 | SLC transporter disorders | 0.748886 | 0.126 |
| R-HSA-1474244 | Extracellular matrix organization | 0.748965 | 0.126 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.755312 | 0.122 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.759384 | 0.120 |
| R-HSA-72306 | tRNA processing | 0.759384 | 0.120 |
| R-HSA-202424 | Downstream TCR signaling | 0.762334 | 0.118 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.762334 | 0.118 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.764490 | 0.117 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.765769 | 0.116 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.769965 | 0.114 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.770027 | 0.113 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.771974 | 0.112 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.772492 | 0.112 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.772492 | 0.112 |
| R-HSA-1474290 | Collagen formation | 0.779022 | 0.108 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.779135 | 0.108 |
| R-HSA-2559583 | Cellular Senescence | 0.783987 | 0.106 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.788470 | 0.103 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.788470 | 0.103 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.791529 | 0.102 |
| R-HSA-1643685 | Disease | 0.792976 | 0.101 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.794544 | 0.100 |
| R-HSA-190236 | Signaling by FGFR | 0.794544 | 0.100 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.797515 | 0.098 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.802057 | 0.096 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.803330 | 0.095 |
| R-HSA-983712 | Ion channel transport | 0.804219 | 0.095 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.806175 | 0.094 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.808979 | 0.092 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.811743 | 0.091 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.813935 | 0.089 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.814029 | 0.089 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.814466 | 0.089 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.814466 | 0.089 |
| R-HSA-9833110 | RSV-host interactions | 0.814466 | 0.089 |
| R-HSA-9609690 | HCMV Early Events | 0.818778 | 0.087 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.820617 | 0.086 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.824975 | 0.084 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.826657 | 0.083 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.827508 | 0.082 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.827508 | 0.082 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.830004 | 0.081 |
| R-HSA-202403 | TCR signaling | 0.830004 | 0.081 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.832363 | 0.080 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.834890 | 0.078 |
| R-HSA-1483257 | Phospholipid metabolism | 0.835566 | 0.078 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.837137 | 0.077 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.837280 | 0.077 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.844246 | 0.074 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.844246 | 0.074 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.846501 | 0.072 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.846501 | 0.072 |
| R-HSA-373760 | L1CAM interactions | 0.848724 | 0.071 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.863411 | 0.064 |
| R-HSA-8951664 | Neddylation | 0.864736 | 0.063 |
| R-HSA-977606 | Regulation of Complement cascade | 0.867341 | 0.062 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.869263 | 0.061 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.869263 | 0.061 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.869263 | 0.061 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.874865 | 0.058 |
| R-HSA-72312 | rRNA processing | 0.880763 | 0.055 |
| R-HSA-9717189 | Sensory perception of taste | 0.881964 | 0.055 |
| R-HSA-157118 | Signaling by NOTCH | 0.891302 | 0.050 |
| R-HSA-5368287 | Mitochondrial translation | 0.894981 | 0.048 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.894981 | 0.048 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.899809 | 0.046 |
| R-HSA-9609646 | HCMV Infection | 0.903263 | 0.044 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.903797 | 0.044 |
| R-HSA-421270 | Cell-cell junction organization | 0.904389 | 0.044 |
| R-HSA-166658 | Complement cascade | 0.906568 | 0.043 |
| R-HSA-2187338 | Visual phototransduction | 0.909260 | 0.041 |
| R-HSA-166520 | Signaling by NTRKs | 0.910577 | 0.041 |
| R-HSA-9758941 | Gastrulation | 0.911875 | 0.040 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.913154 | 0.039 |
| R-HSA-9609507 | Protein localization | 0.916882 | 0.038 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.916985 | 0.038 |
| R-HSA-416476 | G alpha (q) signalling events | 0.917962 | 0.037 |
| R-HSA-9711097 | Cellular response to starvation | 0.922744 | 0.035 |
| R-HSA-446728 | Cell junction organization | 0.930549 | 0.031 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.933165 | 0.030 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.937949 | 0.028 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.938874 | 0.027 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.938874 | 0.027 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.938874 | 0.027 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.939139 | 0.027 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.945307 | 0.024 |
| R-HSA-1280218 | Adaptive Immune System | 0.948958 | 0.023 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.956364 | 0.019 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.960622 | 0.017 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.967790 | 0.014 |
| R-HSA-1266738 | Developmental Biology | 0.968751 | 0.014 |
| R-HSA-418990 | Adherens junctions interactions | 0.968865 | 0.014 |
| R-HSA-9748784 | Drug ADME | 0.968865 | 0.014 |
| R-HSA-212436 | Generic Transcription Pathway | 0.971804 | 0.012 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.973897 | 0.011 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.975830 | 0.011 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.987122 | 0.006 |
| R-HSA-72766 | Translation | 0.989568 | 0.005 |
| R-HSA-8957322 | Metabolism of steroids | 0.993470 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 0.993560 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 0.996809 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.997720 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.997819 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.998120 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.999667 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999814 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999998 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999998 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.813 | 0.225 | 2 | 0.882 |
GRK1 |
0.795 | 0.168 | -2 | 0.808 |
DSTYK |
0.794 | 0.163 | 2 | 0.879 |
CDC7 |
0.793 | 0.072 | 1 | 0.886 |
CLK3 |
0.792 | 0.110 | 1 | 0.828 |
MOS |
0.792 | 0.141 | 1 | 0.895 |
IKKA |
0.790 | 0.190 | -2 | 0.745 |
PIM3 |
0.787 | 0.057 | -3 | 0.794 |
FAM20C |
0.785 | 0.121 | 2 | 0.669 |
IKKB |
0.784 | 0.077 | -2 | 0.750 |
BMPR1B |
0.784 | 0.174 | 1 | 0.852 |
PRPK |
0.782 | -0.038 | -1 | 0.824 |
RAF1 |
0.780 | 0.027 | 1 | 0.813 |
GRK6 |
0.780 | 0.104 | 1 | 0.846 |
GRK7 |
0.780 | 0.152 | 1 | 0.765 |
GCN2 |
0.779 | -0.013 | 2 | 0.801 |
BMPR2 |
0.778 | 0.060 | -2 | 0.878 |
CAMK2G |
0.778 | 0.004 | 2 | 0.821 |
ATR |
0.777 | 0.028 | 1 | 0.838 |
NDR2 |
0.777 | -0.014 | -3 | 0.791 |
GRK5 |
0.777 | 0.005 | -3 | 0.869 |
NEK6 |
0.777 | 0.048 | -2 | 0.870 |
ULK2 |
0.776 | -0.033 | 2 | 0.803 |
MTOR |
0.775 | -0.023 | 1 | 0.720 |
GRK4 |
0.775 | 0.085 | -2 | 0.835 |
NEK7 |
0.774 | 0.035 | -3 | 0.820 |
SKMLCK |
0.774 | 0.017 | -2 | 0.805 |
MLK1 |
0.773 | 0.049 | 2 | 0.803 |
TBK1 |
0.772 | -0.031 | 1 | 0.677 |
TGFBR2 |
0.772 | 0.000 | -2 | 0.825 |
CHAK2 |
0.771 | 0.026 | -1 | 0.852 |
PDHK4 |
0.771 | -0.182 | 1 | 0.811 |
CAMK1B |
0.770 | -0.061 | -3 | 0.817 |
CDKL1 |
0.770 | -0.008 | -3 | 0.764 |
PIM1 |
0.770 | 0.040 | -3 | 0.731 |
ATM |
0.770 | 0.067 | 1 | 0.789 |
ACVR2B |
0.770 | 0.130 | -2 | 0.825 |
TGFBR1 |
0.769 | 0.082 | -2 | 0.810 |
KIS |
0.769 | 0.017 | 1 | 0.649 |
BMPR1A |
0.769 | 0.161 | 1 | 0.840 |
ERK5 |
0.769 | 0.008 | 1 | 0.779 |
RIPK3 |
0.769 | -0.055 | 3 | 0.755 |
NLK |
0.769 | -0.040 | 1 | 0.784 |
IKKE |
0.769 | -0.028 | 1 | 0.669 |
MARK4 |
0.768 | -0.016 | 4 | 0.801 |
HUNK |
0.768 | -0.016 | 2 | 0.841 |
ULK1 |
0.768 | -0.057 | -3 | 0.828 |
PKN3 |
0.768 | -0.010 | -3 | 0.785 |
ACVR2A |
0.767 | 0.111 | -2 | 0.816 |
PLK1 |
0.767 | 0.061 | -2 | 0.836 |
RSK2 |
0.766 | -0.014 | -3 | 0.709 |
ALK4 |
0.766 | 0.056 | -2 | 0.837 |
LATS1 |
0.766 | 0.032 | -3 | 0.807 |
MLK4 |
0.766 | 0.116 | 2 | 0.721 |
ALK2 |
0.766 | 0.112 | -2 | 0.830 |
MST4 |
0.765 | -0.027 | 2 | 0.812 |
NDR1 |
0.765 | -0.055 | -3 | 0.777 |
NIK |
0.765 | -0.083 | -3 | 0.841 |
MLK3 |
0.764 | 0.057 | 2 | 0.723 |
PKCD |
0.763 | 0.008 | 2 | 0.781 |
SRPK1 |
0.762 | -0.009 | -3 | 0.701 |
DLK |
0.762 | -0.030 | 1 | 0.808 |
CAMLCK |
0.762 | -0.060 | -2 | 0.808 |
LATS2 |
0.762 | -0.044 | -5 | 0.624 |
PDHK1 |
0.762 | -0.175 | 1 | 0.796 |
NUAK2 |
0.762 | -0.051 | -3 | 0.779 |
PRKD1 |
0.762 | -0.039 | -3 | 0.759 |
ANKRD3 |
0.761 | -0.046 | 1 | 0.831 |
TSSK2 |
0.761 | -0.026 | -5 | 0.641 |
P90RSK |
0.761 | -0.039 | -3 | 0.722 |
PKR |
0.761 | 0.027 | 1 | 0.838 |
DAPK2 |
0.761 | -0.069 | -3 | 0.820 |
WNK1 |
0.760 | -0.104 | -2 | 0.827 |
CAMK2B |
0.760 | 0.023 | 2 | 0.800 |
TLK2 |
0.759 | 0.087 | 1 | 0.790 |
GRK2 |
0.759 | 0.037 | -2 | 0.723 |
CDK1 |
0.759 | 0.036 | 1 | 0.596 |
MASTL |
0.759 | -0.164 | -2 | 0.794 |
NEK9 |
0.758 | -0.079 | 2 | 0.832 |
AMPKA1 |
0.758 | -0.078 | -3 | 0.791 |
CDKL5 |
0.758 | -0.040 | -3 | 0.749 |
NIM1 |
0.758 | -0.045 | 3 | 0.769 |
BRAF |
0.758 | 0.062 | -4 | 0.276 |
IRE1 |
0.757 | -0.043 | 1 | 0.791 |
RSK4 |
0.757 | 0.009 | -3 | 0.685 |
PLK3 |
0.757 | 0.035 | 2 | 0.796 |
CDK8 |
0.757 | -0.004 | 1 | 0.628 |
TSSK1 |
0.757 | -0.030 | -3 | 0.812 |
ICK |
0.756 | -0.037 | -3 | 0.794 |
RSK3 |
0.756 | -0.049 | -3 | 0.709 |
TTBK2 |
0.756 | -0.072 | 2 | 0.722 |
WNK3 |
0.756 | -0.147 | 1 | 0.781 |
CAMK2D |
0.756 | -0.089 | -3 | 0.782 |
P70S6KB |
0.756 | -0.054 | -3 | 0.738 |
PKN2 |
0.756 | -0.081 | -3 | 0.773 |
PRKD2 |
0.755 | -0.033 | -3 | 0.693 |
BCKDK |
0.755 | -0.119 | -1 | 0.770 |
MEK1 |
0.755 | -0.012 | 2 | 0.861 |
JNK3 |
0.755 | 0.023 | 1 | 0.600 |
PKACG |
0.755 | -0.049 | -2 | 0.706 |
CK2A2 |
0.754 | 0.091 | 1 | 0.762 |
HIPK4 |
0.754 | -0.055 | 1 | 0.758 |
CDK5 |
0.754 | 0.015 | 1 | 0.666 |
MLK2 |
0.753 | -0.086 | 2 | 0.810 |
RIPK1 |
0.753 | -0.145 | 1 | 0.789 |
SRPK2 |
0.753 | -0.014 | -3 | 0.628 |
SRPK3 |
0.753 | -0.016 | -3 | 0.690 |
GAK |
0.753 | 0.174 | 1 | 0.890 |
QSK |
0.752 | -0.020 | 4 | 0.781 |
AURC |
0.752 | -0.023 | -2 | 0.619 |
IRE2 |
0.752 | -0.027 | 2 | 0.751 |
MAPKAPK2 |
0.752 | -0.020 | -3 | 0.664 |
MEKK3 |
0.752 | 0.006 | 1 | 0.768 |
MEKK2 |
0.752 | 0.086 | 2 | 0.811 |
CK1E |
0.752 | 0.009 | -3 | 0.601 |
YSK4 |
0.751 | -0.044 | 1 | 0.727 |
CAMK2A |
0.751 | -0.019 | 2 | 0.795 |
VRK2 |
0.751 | -0.109 | 1 | 0.853 |
GRK3 |
0.751 | 0.044 | -2 | 0.688 |
PKCB |
0.750 | -0.036 | 2 | 0.724 |
JNK2 |
0.750 | 0.013 | 1 | 0.563 |
CLK2 |
0.750 | 0.031 | -3 | 0.697 |
CDK19 |
0.749 | -0.013 | 1 | 0.590 |
GSK3A |
0.749 | 0.068 | 4 | 0.534 |
AMPKA2 |
0.749 | -0.086 | -3 | 0.751 |
PINK1 |
0.749 | 0.053 | 1 | 0.823 |
MARK2 |
0.749 | -0.006 | 4 | 0.707 |
NUAK1 |
0.749 | -0.044 | -3 | 0.728 |
MSK2 |
0.749 | -0.044 | -3 | 0.690 |
PASK |
0.749 | 0.063 | -3 | 0.807 |
PAK1 |
0.749 | -0.051 | -2 | 0.718 |
PLK2 |
0.749 | 0.115 | -3 | 0.852 |
SMG1 |
0.748 | -0.039 | 1 | 0.790 |
PKCA |
0.748 | -0.034 | 2 | 0.714 |
SIK |
0.748 | -0.019 | -3 | 0.698 |
DYRK2 |
0.748 | -0.025 | 1 | 0.661 |
MARK3 |
0.747 | -0.023 | 4 | 0.748 |
PKCG |
0.747 | -0.053 | 2 | 0.717 |
PLK4 |
0.747 | -0.027 | 2 | 0.676 |
CHAK1 |
0.747 | -0.043 | 2 | 0.737 |
CDK2 |
0.747 | -0.001 | 1 | 0.680 |
PERK |
0.747 | -0.038 | -2 | 0.855 |
PRKX |
0.746 | 0.018 | -3 | 0.593 |
MAPKAPK3 |
0.746 | -0.099 | -3 | 0.703 |
PKCZ |
0.746 | -0.052 | 2 | 0.771 |
PKACB |
0.746 | -0.010 | -2 | 0.634 |
CK1D |
0.745 | 0.009 | -3 | 0.553 |
QIK |
0.745 | -0.108 | -3 | 0.769 |
DRAK1 |
0.745 | -0.025 | 1 | 0.753 |
TLK1 |
0.745 | -0.032 | -2 | 0.831 |
MEKK1 |
0.745 | -0.016 | 1 | 0.785 |
MSK1 |
0.744 | -0.030 | -3 | 0.689 |
CAMK4 |
0.744 | -0.124 | -3 | 0.758 |
CLK4 |
0.744 | -0.030 | -3 | 0.708 |
CDK3 |
0.744 | 0.030 | 1 | 0.536 |
CHK1 |
0.744 | -0.040 | -3 | 0.771 |
DNAPK |
0.744 | -0.004 | 1 | 0.668 |
GSK3B |
0.744 | 0.024 | 4 | 0.524 |
MELK |
0.744 | -0.091 | -3 | 0.731 |
PKCH |
0.743 | -0.051 | 2 | 0.718 |
NEK5 |
0.743 | -0.015 | 1 | 0.818 |
AURB |
0.743 | -0.038 | -2 | 0.615 |
P38A |
0.743 | -0.013 | 1 | 0.660 |
P38G |
0.743 | 0.005 | 1 | 0.500 |
ZAK |
0.742 | -0.026 | 1 | 0.740 |
TAO3 |
0.742 | 0.056 | 1 | 0.754 |
ERK1 |
0.742 | 0.005 | 1 | 0.570 |
CDK18 |
0.742 | -0.015 | 1 | 0.570 |
CK2A1 |
0.742 | 0.072 | 1 | 0.735 |
CDK13 |
0.742 | -0.034 | 1 | 0.602 |
PAK3 |
0.741 | -0.102 | -2 | 0.716 |
NEK2 |
0.741 | -0.115 | 2 | 0.797 |
ERK2 |
0.741 | -0.006 | 1 | 0.610 |
CK1A2 |
0.741 | 0.002 | -3 | 0.549 |
PRP4 |
0.741 | -0.006 | -3 | 0.739 |
MNK2 |
0.741 | -0.095 | -2 | 0.741 |
MEK5 |
0.740 | -0.109 | 2 | 0.832 |
CK1G1 |
0.740 | -0.013 | -3 | 0.609 |
HRI |
0.740 | -0.107 | -2 | 0.850 |
PIM2 |
0.740 | -0.033 | -3 | 0.681 |
P38B |
0.740 | -0.005 | 1 | 0.585 |
AURA |
0.740 | -0.019 | -2 | 0.587 |
CAMKK1 |
0.739 | 0.002 | -2 | 0.786 |
CLK1 |
0.739 | -0.032 | -3 | 0.670 |
MYLK4 |
0.739 | -0.072 | -2 | 0.715 |
MARK1 |
0.739 | -0.053 | 4 | 0.758 |
CDK17 |
0.739 | -0.013 | 1 | 0.512 |
MNK1 |
0.739 | -0.083 | -2 | 0.759 |
PRKD3 |
0.738 | -0.072 | -3 | 0.667 |
MST2 |
0.738 | 0.053 | 1 | 0.779 |
PAK2 |
0.738 | -0.081 | -2 | 0.710 |
MST3 |
0.738 | -0.036 | 2 | 0.803 |
NEK8 |
0.738 | -0.006 | 2 | 0.807 |
DCAMKL1 |
0.737 | -0.050 | -3 | 0.708 |
AKT2 |
0.737 | -0.032 | -3 | 0.619 |
CDK7 |
0.737 | -0.073 | 1 | 0.637 |
CAMK1G |
0.736 | -0.079 | -3 | 0.706 |
BRSK1 |
0.736 | -0.089 | -3 | 0.726 |
IRAK4 |
0.736 | -0.088 | 1 | 0.791 |
JNK1 |
0.735 | 0.013 | 1 | 0.558 |
P38D |
0.735 | 0.019 | 1 | 0.529 |
SGK3 |
0.735 | -0.057 | -3 | 0.679 |
WNK4 |
0.735 | -0.114 | -2 | 0.828 |
MPSK1 |
0.735 | -0.009 | 1 | 0.821 |
CAMKK2 |
0.733 | -0.044 | -2 | 0.771 |
PKG2 |
0.733 | -0.061 | -2 | 0.642 |
HIPK2 |
0.733 | -0.018 | 1 | 0.570 |
HIPK1 |
0.733 | -0.038 | 1 | 0.680 |
SMMLCK |
0.732 | -0.085 | -3 | 0.762 |
CDK16 |
0.731 | -0.007 | 1 | 0.534 |
BRSK2 |
0.731 | -0.137 | -3 | 0.745 |
LKB1 |
0.731 | -0.069 | -3 | 0.797 |
CDK12 |
0.730 | -0.045 | 1 | 0.567 |
PHKG1 |
0.730 | -0.132 | -3 | 0.763 |
PAK6 |
0.730 | -0.063 | -2 | 0.654 |
CDK14 |
0.730 | -0.036 | 1 | 0.611 |
EEF2K |
0.730 | -0.034 | 3 | 0.804 |
TTK |
0.729 | 0.116 | -2 | 0.841 |
SSTK |
0.729 | -0.085 | 4 | 0.759 |
SNRK |
0.729 | -0.166 | 2 | 0.713 |
DAPK3 |
0.729 | -0.027 | -3 | 0.738 |
GCK |
0.728 | -0.023 | 1 | 0.761 |
TAK1 |
0.728 | 0.018 | 1 | 0.798 |
DYRK1A |
0.728 | -0.044 | 1 | 0.685 |
PKCT |
0.728 | -0.065 | 2 | 0.729 |
MAPKAPK5 |
0.728 | -0.114 | -3 | 0.665 |
DYRK4 |
0.728 | -0.028 | 1 | 0.583 |
IRAK1 |
0.727 | -0.142 | -1 | 0.694 |
AKT1 |
0.727 | -0.030 | -3 | 0.626 |
TNIK |
0.726 | 0.003 | 3 | 0.815 |
PKACA |
0.726 | -0.028 | -2 | 0.584 |
NEK11 |
0.726 | -0.144 | 1 | 0.737 |
DCAMKL2 |
0.726 | -0.084 | -3 | 0.734 |
TAO2 |
0.725 | -0.078 | 2 | 0.835 |
ALPHAK3 |
0.725 | 0.122 | -1 | 0.752 |
CDK9 |
0.725 | -0.077 | 1 | 0.606 |
MINK |
0.724 | -0.046 | 1 | 0.748 |
P70S6K |
0.724 | -0.075 | -3 | 0.641 |
TTBK1 |
0.724 | -0.122 | 2 | 0.638 |
OSR1 |
0.723 | 0.096 | 2 | 0.806 |
DYRK3 |
0.723 | -0.044 | 1 | 0.682 |
DYRK1B |
0.723 | -0.052 | 1 | 0.620 |
CAMK1D |
0.723 | -0.061 | -3 | 0.608 |
MST1 |
0.722 | -0.031 | 1 | 0.752 |
PDK1 |
0.722 | -0.094 | 1 | 0.739 |
HGK |
0.722 | -0.056 | 3 | 0.818 |
DAPK1 |
0.722 | -0.036 | -3 | 0.721 |
VRK1 |
0.722 | -0.072 | 2 | 0.855 |
CK1A |
0.721 | 0.002 | -3 | 0.472 |
PKCI |
0.721 | -0.089 | 2 | 0.733 |
CDK10 |
0.721 | -0.050 | 1 | 0.600 |
PKCE |
0.720 | -0.054 | 2 | 0.697 |
LRRK2 |
0.719 | -0.129 | 2 | 0.837 |
HIPK3 |
0.719 | -0.079 | 1 | 0.657 |
NEK4 |
0.719 | -0.127 | 1 | 0.759 |
PBK |
0.719 | 0.004 | 1 | 0.830 |
ERK7 |
0.717 | -0.023 | 2 | 0.511 |
MEKK6 |
0.717 | -0.128 | 1 | 0.761 |
NEK1 |
0.716 | -0.105 | 1 | 0.777 |
PHKG2 |
0.716 | -0.122 | -3 | 0.720 |
MAP3K15 |
0.716 | -0.116 | 1 | 0.712 |
MAK |
0.716 | -0.006 | -2 | 0.666 |
CDK6 |
0.715 | -0.028 | 1 | 0.588 |
ROCK2 |
0.714 | -0.048 | -3 | 0.712 |
STK33 |
0.714 | -0.106 | 2 | 0.630 |
HPK1 |
0.714 | -0.102 | 1 | 0.732 |
PDHK3_TYR |
0.714 | 0.078 | 4 | 0.864 |
MRCKA |
0.713 | -0.064 | -3 | 0.682 |
SGK1 |
0.713 | -0.030 | -3 | 0.538 |
SLK |
0.712 | -0.056 | -2 | 0.711 |
PAK5 |
0.712 | -0.076 | -2 | 0.593 |
AKT3 |
0.712 | -0.037 | -3 | 0.551 |
KHS2 |
0.711 | -0.042 | 1 | 0.739 |
YSK1 |
0.711 | -0.074 | 2 | 0.788 |
MRCKB |
0.711 | -0.060 | -3 | 0.663 |
KHS1 |
0.711 | -0.070 | 1 | 0.726 |
LOK |
0.710 | -0.106 | -2 | 0.752 |
MEK2 |
0.710 | -0.130 | 2 | 0.832 |
DMPK1 |
0.709 | -0.040 | -3 | 0.682 |
BUB1 |
0.709 | -0.030 | -5 | 0.618 |
PAK4 |
0.709 | -0.072 | -2 | 0.593 |
BIKE |
0.709 | 0.055 | 1 | 0.804 |
BMPR2_TYR |
0.708 | 0.072 | -1 | 0.850 |
CHK2 |
0.708 | -0.061 | -3 | 0.552 |
PDHK4_TYR |
0.708 | 0.074 | 2 | 0.866 |
MAP2K6_TYR |
0.708 | 0.096 | -1 | 0.856 |
CDK4 |
0.708 | -0.043 | 1 | 0.559 |
RIPK2 |
0.707 | -0.174 | 1 | 0.690 |
MOK |
0.707 | -0.048 | 1 | 0.709 |
CAMK1A |
0.705 | -0.079 | -3 | 0.575 |
PKN1 |
0.704 | -0.098 | -3 | 0.645 |
YANK3 |
0.704 | -0.024 | 2 | 0.410 |
PDHK1_TYR |
0.704 | 0.070 | -1 | 0.869 |
MAP2K4_TYR |
0.704 | 0.018 | -1 | 0.842 |
SBK |
0.704 | -0.056 | -3 | 0.496 |
MYO3A |
0.702 | -0.013 | 1 | 0.746 |
MYO3B |
0.701 | -0.040 | 2 | 0.789 |
TXK |
0.701 | 0.139 | 1 | 0.871 |
PKMYT1_TYR |
0.700 | -0.064 | 3 | 0.820 |
HASPIN |
0.700 | -0.038 | -1 | 0.697 |
NEK3 |
0.700 | -0.155 | 1 | 0.711 |
EPHA6 |
0.700 | 0.035 | -1 | 0.820 |
PINK1_TYR |
0.700 | 0.050 | 1 | 0.814 |
BLK |
0.700 | 0.170 | -1 | 0.779 |
TESK1_TYR |
0.699 | -0.117 | 3 | 0.841 |
ROCK1 |
0.698 | -0.064 | -3 | 0.677 |
MAP2K7_TYR |
0.698 | -0.115 | 2 | 0.856 |
YES1 |
0.697 | 0.109 | -1 | 0.776 |
FGR |
0.697 | 0.073 | 1 | 0.873 |
FER |
0.696 | 0.095 | 1 | 0.894 |
LCK |
0.696 | 0.146 | -1 | 0.763 |
FYN |
0.696 | 0.165 | -1 | 0.744 |
EPHB4 |
0.696 | 0.036 | -1 | 0.781 |
ASK1 |
0.695 | -0.111 | 1 | 0.699 |
CK1G3 |
0.694 | -0.008 | -3 | 0.427 |
CRIK |
0.694 | -0.065 | -3 | 0.629 |
AAK1 |
0.693 | 0.075 | 1 | 0.713 |
HCK |
0.693 | 0.092 | -1 | 0.754 |
STLK3 |
0.692 | -0.041 | 1 | 0.709 |
ABL2 |
0.692 | 0.086 | -1 | 0.758 |
EPHA4 |
0.691 | 0.034 | 2 | 0.788 |
PKG1 |
0.690 | -0.082 | -2 | 0.564 |
INSRR |
0.690 | 0.029 | 3 | 0.737 |
SRMS |
0.690 | 0.033 | 1 | 0.874 |
CSF1R |
0.689 | 0.034 | 3 | 0.769 |
TAO1 |
0.689 | -0.090 | 1 | 0.665 |
EPHB2 |
0.689 | 0.057 | -1 | 0.755 |
TYRO3 |
0.689 | -0.028 | 3 | 0.772 |
ITK |
0.689 | 0.057 | -1 | 0.717 |
ROS1 |
0.688 | -0.022 | 3 | 0.755 |
LIMK2_TYR |
0.688 | -0.129 | -3 | 0.845 |
TYK2 |
0.688 | -0.042 | 1 | 0.761 |
EPHB3 |
0.687 | 0.043 | -1 | 0.759 |
EPHB1 |
0.687 | 0.027 | 1 | 0.856 |
LIMK1_TYR |
0.687 | -0.144 | 2 | 0.848 |
RET |
0.686 | -0.082 | 1 | 0.760 |
ABL1 |
0.686 | 0.040 | -1 | 0.743 |
CK1G2 |
0.686 | 0.007 | -3 | 0.523 |
JAK3 |
0.686 | -0.012 | 1 | 0.737 |
MST1R |
0.684 | -0.100 | 3 | 0.780 |
FLT3 |
0.684 | 0.033 | 3 | 0.768 |
KIT |
0.683 | 0.012 | 3 | 0.777 |
BMX |
0.683 | 0.038 | -1 | 0.656 |
JAK2 |
0.683 | -0.055 | 1 | 0.747 |
LYN |
0.683 | 0.083 | 3 | 0.707 |
SYK |
0.683 | 0.107 | -1 | 0.751 |
SRC |
0.682 | 0.087 | -1 | 0.737 |
MET |
0.682 | 0.029 | 3 | 0.754 |
KDR |
0.682 | -0.009 | 3 | 0.743 |
DDR1 |
0.681 | -0.142 | 4 | 0.777 |
FRK |
0.681 | 0.081 | -1 | 0.774 |
TNK2 |
0.680 | -0.065 | 3 | 0.740 |
TEC |
0.680 | 0.039 | -1 | 0.644 |
FGFR2 |
0.680 | -0.045 | 3 | 0.781 |
PTK2 |
0.680 | 0.074 | -1 | 0.754 |
MERTK |
0.680 | 0.024 | 3 | 0.752 |
FLT1 |
0.679 | 0.001 | -1 | 0.799 |
PDGFRB |
0.679 | -0.064 | 3 | 0.784 |
EPHA7 |
0.678 | 0.003 | 2 | 0.798 |
EPHA5 |
0.678 | 0.060 | 2 | 0.787 |
YANK2 |
0.678 | -0.023 | 2 | 0.429 |
EPHA8 |
0.677 | 0.067 | -1 | 0.762 |
MATK |
0.676 | 0.020 | -1 | 0.713 |
BTK |
0.675 | -0.016 | -1 | 0.668 |
ERBB2 |
0.675 | -0.020 | 1 | 0.730 |
NTRK1 |
0.675 | -0.032 | -1 | 0.763 |
TEK |
0.675 | -0.085 | 3 | 0.731 |
AXL |
0.674 | -0.059 | 3 | 0.757 |
FGFR3 |
0.674 | -0.010 | 3 | 0.756 |
WEE1_TYR |
0.674 | -0.031 | -1 | 0.692 |
EPHA3 |
0.673 | -0.046 | 2 | 0.767 |
EGFR |
0.673 | 0.021 | 1 | 0.644 |
PTK6 |
0.672 | -0.026 | -1 | 0.640 |
TNNI3K_TYR |
0.672 | -0.086 | 1 | 0.795 |
FGFR1 |
0.672 | -0.077 | 3 | 0.749 |
LTK |
0.672 | -0.042 | 3 | 0.728 |
NTRK3 |
0.672 | 0.008 | -1 | 0.723 |
INSR |
0.671 | -0.030 | 3 | 0.711 |
TNK1 |
0.670 | -0.101 | 3 | 0.755 |
ALK |
0.670 | -0.054 | 3 | 0.705 |
NTRK2 |
0.670 | -0.035 | 3 | 0.739 |
FLT4 |
0.669 | -0.056 | 3 | 0.748 |
CSK |
0.669 | 0.022 | 2 | 0.796 |
FGFR4 |
0.669 | 0.040 | -1 | 0.721 |
PTK2B |
0.667 | -0.043 | -1 | 0.689 |
JAK1 |
0.667 | -0.078 | 1 | 0.679 |
EPHA1 |
0.666 | -0.060 | 3 | 0.739 |
ERBB4 |
0.665 | 0.030 | 1 | 0.691 |
PDGFRA |
0.664 | -0.165 | 3 | 0.784 |
NEK10_TYR |
0.664 | -0.117 | 1 | 0.604 |
EPHA2 |
0.664 | 0.014 | -1 | 0.725 |
IGF1R |
0.662 | 0.015 | 3 | 0.660 |
DDR2 |
0.662 | -0.082 | 3 | 0.727 |
ZAP70 |
0.655 | 0.050 | -1 | 0.690 |
MUSK |
0.650 | -0.082 | 1 | 0.637 |
FES |
0.647 | -0.038 | -1 | 0.626 |