Motif 734 (n=177)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4FU01 | MTMR11 | S180 | ochoa | Myotubularin-related protein 11 (Cisplatin resistance-associated protein) (hCRA) (Inactive phosphatidylinositol 3-phosphatase 11) | None |
| A6NDU8 | RIMOC1 | S238 | ochoa | RAB7A-interacting MON1-CCZ1 complex subunit 1 (UPF0600 protein C5orf51) | Plays an important role in the removal of damaged mitochondria via mitophagy by controlling the stability and localization of RAB7A. Required for the recruitment of RAB7A and ATG9A vesicles to damaged mitochondria and promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy. {ECO:0000269|PubMed:34432599}. |
| C4AMC7 | WASH3P | S366 | ochoa | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
| O00622 | CCN1 | S84 | ochoa | CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1) | Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}. |
| O43896 | KIF1C | S990 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| O60716 | CTNND1 | S97 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75116 | ROCK2 | S1137 | ochoa | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O75436 | VPS26A | S47 | ochoa | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250|UniProtKB:P40336, ECO:0000269|PubMed:15078902, ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:22279231, ECO:0000303|PubMed:20923837, ECO:0000303|PubMed:21602791, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491, ECO:0000305}. |
| O95164 | UBL3 | S31 | ochoa | Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1) | None |
| O95425 | SVIL | S86 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95453 | PARN | S562 | ochoa | Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417). {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:9736620}. |
| O95747 | OXSR1 | S347 | ochoa | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}. |
| O95801 | TTC4 | S267 | ochoa | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. |
| O95810 | CAVIN2 | S177 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P05023 | ATP1A1 | S217 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P05455 | SSB | S160 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P07237 | P4HB | S331 | ochoa|psp | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P07550 | ADRB2 | S356 | psp | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}. |
| P07814 | EPRS1 | S1000 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P0DPH7 | TUBA3C | S54 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S54 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10451 | SPP1 | S195 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P12429 | ANXA3 | S149 | ochoa | Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III) | Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. |
| P12882 | MYH1 | S1303 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1299 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P17844 | DDX5 | S198 | psp | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| P18206 | VCL | S816 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P18583 | SON | S1585 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19367 | HK1 | S447 | ochoa | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) | Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}. |
| P21333 | FLNA | S2042 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P23443 | RPS6KB1 | S53 | psp | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| P23443 | RPS6KB1 | S403 | ochoa|psp | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| P26951 | IL3RA | S348 | ochoa | Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123) | Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity). {ECO:0000250|UniProtKB:P26952, ECO:0000269|PubMed:10527461, ECO:0000269|PubMed:29374162}. |
| P27816 | MAP4 | S609 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29323 | EPHB2 | S586 | ochoa | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| P29401 | TKT | S256 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P30086 | PEBP1 | S109 | ochoa|psp | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P34910 | EVI2B | S242 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P34910 | EVI2B | S271 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P36871 | PGM1 | S505 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P38919 | EIF4A3 | S84 | ochoa | Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] | ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:16170325, PubMed:16209946, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly (PubMed:22203037). Involved in craniofacial development (PubMed:24360810). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15034551, ECO:0000269|PubMed:16170325, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16314458, ECO:0000269|PubMed:16923391, ECO:0000269|PubMed:16931718, ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:19033377, ECO:0000269|PubMed:19409878, ECO:0000269|PubMed:20479275, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:24360810, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| P41235 | HNF4A | S303 | psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P42574 | CASP3 | S150 | psp | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:7596430). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (PubMed:10497198, PubMed:16374543, PubMed:7596430, PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively) (PubMed:7596430). Cleaves and inactivates interleukin-18 (IL18) (PubMed:37993714, PubMed:9334240). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed:35338844, PubMed:35446120). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:Q60431, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:30878284, ECO:0000269|PubMed:33725486, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7596430, ECO:0000269|PubMed:7774019, ECO:0000269|PubMed:8696339, ECO:0000269|PubMed:9334240}. |
| P43121 | MCAM | S238 | ochoa | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
| P43686 | PSMC4 | S21 | ochoa | 26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:8060531}. |
| P49711 | CTCF | S461 | ochoa | Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) | Chromatin binding factor that binds to DNA sequence specific sites and regulates the 3D structure of chromatin (PubMed:18347100, PubMed:18654629, PubMed:19322193). Binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures, such as the nuclear lamina (PubMed:18347100, PubMed:18654629, PubMed:19322193). Defines the boundaries between active and heterochromatic DNA via binding to chromatin insulators, thereby preventing interaction between promoter and nearby enhancers and silencers (PubMed:18347100, PubMed:18654629, PubMed:19322193). Plays a critical role in the epigenetic regulation (PubMed:16949368). Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus (PubMed:16107875, PubMed:16815976, PubMed:17827499). On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2 (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory (By similarity). Regulates asynchronous replication of IGF2/H19 (By similarity). Plays a critical role in gene silencing over considerable distances in the genome (By similarity). Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones (PubMed:18413740). Inversely, binding to target sites is prevented by CpG methylation (PubMed:18413740). Plays an important role in chromatin remodeling (PubMed:18413740). Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (PubMed:12191639). Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription (PubMed:12191639). When bound to chromatin, it provides an anchor point for nucleosomes positioning (PubMed:12191639). Seems to be essential for homologous X-chromosome pairing (By similarity). May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation (PubMed:11743158). May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation (PubMed:11743158). Involved in sister chromatid cohesion (PubMed:12191639). Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites (PubMed:18550811). Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640). Acts as a transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene (PubMed:18413740, PubMed:8649389, PubMed:9591631). Also binds to the PLK and PIM1 promoters (PubMed:12191639). Acts as a transcriptional activator of APP (PubMed:9407128). Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression (PubMed:18347100, PubMed:19322193). Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription (By similarity). Seems to act as tumor suppressor (PubMed:12191639). {ECO:0000250|UniProtKB:Q61164, ECO:0000269|PubMed:11743158, ECO:0000269|PubMed:16107875, ECO:0000269|PubMed:16815976, ECO:0000269|PubMed:16949368, ECO:0000269|PubMed:17827499, ECO:0000269|PubMed:18347100, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18550811, ECO:0000269|PubMed:18654629, ECO:0000269|PubMed:19322193, ECO:0000269|PubMed:26321640, ECO:0000269|PubMed:8649389, ECO:0000269|PubMed:9407128, ECO:0000269|PubMed:9591631, ECO:0000303|PubMed:12191639}. |
| P50851 | LRBA | S1237 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P54132 | BLM | S527 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P60842 | EIF4A1 | S78 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P60842 | EIF4A1 | S205 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P62081 | RPS7 | S174 | ochoa | Small ribosomal subunit protein eS7 (40S ribosomal protein S7) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for rRNA maturation (PubMed:19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P68363 | TUBA1B | S54 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q02241 | KIF23 | S155 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q03989 | ARID5A | S23 | ochoa | AT-rich interactive domain-containing protein 5A (ARID domain-containing protein 5A) (Modulator recognition factor 1) (MRF-1) | DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As an RNA-binding protein, involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as STAT3 and TBX21 (By similarity). Also stabilizes IL6 mRNA (PubMed:32209697). Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity). {ECO:0000250|UniProtKB:Q3U108, ECO:0000269|PubMed:15941852, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:8649988}. |
| Q04637 | EIF4G1 | S1145 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q05048 | CSTF1 | Y67 | ochoa | Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (PubMed:10669729). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (PubMed:10669729). {ECO:0000303|PubMed:10669729}. |
| Q08J23 | NSUN2 | S475 | ochoa | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
| Q13033 | STRN3 | S229 | ochoa | Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}. |
| Q13148 | TARDBP | S254 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| Q13151 | HNRNPA0 | S135 | ochoa | Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) | mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}. |
| Q13164 | MAPK7 | S731 | ochoa|psp | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q13427 | PPIG | S386 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13523 | PRP4K | S93 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13541 | EIF4EBP1 | S44 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
| Q13542 | EIF4EBP2 | S44 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q14126 | DSG2 | S972 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14160 | SCRIB | S748 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14240 | EIF4A2 | S79 | ochoa | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
| Q14315 | FLNC | S1449 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14511 | NEDD9 | S111 | ochoa | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] | Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250|UniProtKB:A0A8I3PDQ1, ECO:0000250|UniProtKB:O35177, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:9020138}. |
| Q14966 | ZNF638 | S289 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15361 | TTF1 | S81 | ochoa | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}. |
| Q15464 | SHB | S258 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15714 | TSC22D1 | S414 | ochoa | TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) | Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:P62500, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:15881652, ECO:0000269|PubMed:18325344, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:26752201, ECO:0000269|PubMed:9022669}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}. |
| Q15723 | ELF2 | S304 | ochoa | ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor) | Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.; FUNCTION: Isoform 2 may function in repression of RUNX1-mediated transactivation. |
| Q15835 | GRK1 | S491 | psp | Rhodopsin kinase GRK1 (RK) (EC 2.7.11.14) (G protein-coupled receptor kinase 1) | Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity). {ECO:0000250|UniProtKB:Q9WVL4, ECO:0000269|PubMed:15946941}. |
| Q16821 | PPP1R3A | S551 | ochoa | Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit) (RG1) | Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). {ECO:0000250}. |
| Q27J81 | INF2 | S1136 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2NKX8 | ERCC6L | S988 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q2TAL5 | SMTNL2 | S127 | ochoa | Smoothelin-like protein 2 | None |
| Q49A88 | CCDC14 | S124 | ochoa | Coiled-coil domain-containing protein 14 | Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. |
| Q53HC9 | EIPR1 | S306 | ochoa | EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) | Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity). {ECO:0000250|UniProtKB:Q5PPK9, ECO:0000269|PubMed:27440922}. |
| Q5HYJ3 | FAM76B | S237 | ochoa | Protein FAM76B | Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm (PubMed:37643469). Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling (PubMed:38421448). {ECO:0000269|PubMed:37643469, ECO:0000269|PubMed:38421448}. |
| Q5QJE6 | DNTTIP2 | S274 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SYE7 | NHSL1 | S378 | ochoa | NHS-like protein 1 | None |
| Q5SYE7 | NHSL1 | S1251 | ochoa | NHS-like protein 1 | None |
| Q5W0B1 | OBI1 | S561 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q6PEY2 | TUBA3E | S54 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6UXY8 | TMC5 | S143 | ochoa | Transmembrane channel-like protein 5 | Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}. |
| Q6VEQ5 | WASH2P | S368 | ochoa | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
| Q6WCQ1 | MPRIP | S663 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q71U36 | TUBA1A | S54 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z2K8 | GPRIN1 | S134 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z6I6 | ARHGAP30 | S840 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86T90 | KIAA1328 | S68 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86TC9 | MYPN | S613 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q8IWV8 | UBR2 | S734 | ochoa | E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:20835242, PubMed:28392261). Recognizes and binds to proteins bearing specific N-terminal residues (N-degrons) that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:20835242, PubMed:28392261). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:20835242, PubMed:28392261). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:20835242). In contrast, it strongly binds methylated N-degrons (PubMed:28392261). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (By similarity). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity). Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis (By similarity). Plays a role in T-cell receptor signaling by inducing 'Lys-63'-linked ubiquitination of lymphocyte cell-specific kinase LCK (PubMed:38225265). This activity is regulated by DUSP22, which induces 'Lys-48'-linked ubiquitination of UBR2, leading to its proteasomal degradation by SCF E3 ubiquitin-protein ligase complex (PubMed:38225265). {ECO:0000250|UniProtKB:Q6WKZ8, ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242, ECO:0000269|PubMed:28392261, ECO:0000269|PubMed:38225265}. |
| Q8IYJ3 | SYTL1 | S69 | psp | Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) | May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}. |
| Q8N1G2 | CMTR1 | S121 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N1W1 | ARHGEF28 | S758 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
| Q8N344 | MIER2 | S107 | ochoa | Mesoderm induction early response protein 2 (Mi-er2) | Transcriptional repressor. {ECO:0000250}. |
| Q8N573 | OXR1 | S388 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N6H7 | ARFGAP2 | S368 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8ND04 | SMG8 | S469 | ochoa | Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269|PubMed:19417104}. |
| Q8NFC6 | BOD1L1 | S262 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8TAD8 | SNIP1 | S159 | ochoa | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8TES7 | FBF1 | S130 | ochoa | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
| Q8WY91 | THAP4 | S237 | ochoa | Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4) | Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000269|PubMed:30524950, ECO:0000269|PubMed:32295384}. |
| Q92614 | MYO18A | S736 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92785 | DPF2 | S142 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q96D46 | NMD3 | S468 | ochoa | 60S ribosomal export protein NMD3 (hNMD3) | Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}. |
| Q96EB6 | SIRT1 | S669 | psp | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96GA3 | LTV1 | S408 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96IZ0 | PAWR | S259 | ochoa | PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) | Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}. |
| Q96K76 | USP47 | S910 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96KG9 | SCYL1 | S747 | ochoa | N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) | Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.; FUNCTION: [Isoform 6]: Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269|PubMed:15963946}. |
| Q99550 | MPHOSPH9 | S1137 | ochoa | M-phase phosphoprotein 9 | Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}. |
| Q9BQE3 | TUBA1C | S54 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BX67 | JAM3 | S281 | ochoa|psp | Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)] | Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:11590146, PubMed:11823489). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity). {ECO:0000250|UniProtKB:A3KPA0, ECO:0000250|UniProtKB:Q9D8B7, ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:11823489, ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:23255084, ECO:0000269|PubMed:24357068, ECO:0000305|PubMed:28196865}.; FUNCTION: [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. {ECO:0000269|PubMed:20592283}. |
| Q9BYX2 | TBC1D2 | S295 | ochoa | TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) | Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}. |
| Q9C0B1 | FTO | S173 | ochoa | Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-) | RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:28002401, PubMed:30197295). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:30197295). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}. |
| Q9H4L7 | SMARCAD1 | S132 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H583 | HEATR1 | S1195 | ochoa | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:38225354}. |
| Q9H792 | PEAK1 | S405 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9HCD5 | NCOA5 | S151 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9NQW6 | ANLN | S362 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NSY1 | BMP2K | S728 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NTI5 | PDS5B | S1209 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NVE7 | PANK4 | S63 | ochoa | 4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4) | Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable). {ECO:0000269|PubMed:27322068, ECO:0000305|PubMed:27322068}. |
| Q9NVS9 | PNPO | S165 | ochoa | Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) | Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). {ECO:0000269|PubMed:12824491, ECO:0000269|PubMed:15182361, ECO:0000269|PubMed:15772097}. |
| Q9NXH8 | TOR4A | S87 | ochoa | Torsin-4A (Torsin family 4 member A) | None |
| Q9NXW2 | DNAJB12 | S178 | ochoa | DnaJ homolog subfamily B member 12 | Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21148293, PubMed:21150129). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:21148293). Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}. |
| Q9NY61 | AATF | S203 | ochoa | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9NYF5 | FAM13B | S797 | ochoa | Protein FAM13B (GAP-like protein N61) | None |
| Q9NYI0 | PSD3 | S369 | ochoa | PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3) | Guanine nucleotide exchange factor for ARF6. {ECO:0000250}. |
| Q9NYL9 | TMOD3 | S57 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9NZN5 | ARHGEF12 | S1147 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P0J7 | KCMF1 | S220 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P1Y6 | PHRF1 | S107 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9UK59 | DBR1 | S499 | ochoa | Lariat debranching enzyme (EC 3.1.4.-) | Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:10982890, PubMed:16232320, PubMed:2435736). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem (PubMed:16232320, PubMed:29474921). {ECO:0000269|PubMed:10982890, ECO:0000269|PubMed:16232320, ECO:0000269|PubMed:2435736, ECO:0000269|PubMed:29474921}. |
| Q9UKV3 | ACIN1 | S125 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKX2 | MYH2 | S1305 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULI0 | ATAD2B | S1294 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9UN19 | DAPP1 | S117 | ochoa | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) | May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}. |
| Q9UNP9 | PPIE | Y41 | ochoa | Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:18258190, PubMed:20460131, PubMed:20677832, PubMed:8977107). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:18258190, PubMed:20460131, PubMed:8977107). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:18258190, PubMed:20541251, PubMed:20677832, PubMed:8977107). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20460131, PubMed:20541251, PubMed:20677832). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:18258190, ECO:0000269|PubMed:20460131, ECO:0000269|PubMed:20541251, ECO:0000269|PubMed:20677832, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:8977107}. |
| Q9UPQ0 | LIMCH1 | S907 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9Y2K1 | ZBTB1 | S297 | ochoa | Zinc finger and BTB domain-containing protein 1 | Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). {ECO:0000250|UniProtKB:Q91VL9, ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167, ECO:0000269|PubMed:24657165}. |
| Q9Y2K5 | R3HDM2 | S853 | ochoa | R3H domain-containing protein 2 | None |
| Q9Y2L5 | TRAPPC8 | S269 | ochoa | Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) | Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Involved in collagen secretion (PubMed:32095531). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:26711178, ECO:0000269|PubMed:32095531}. |
| Q9Y4J8 | DTNA | S463 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| P38646 | HSPA9 | S549 | Sugiyama | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P31943 | HNRNPH1 | S285 | Sugiyama | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P52597 | HNRNPF | S285 | Sugiyama | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| Q8WVC0 | LEO1 | S75 | Sugiyama | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| P55795 | HNRNPH2 | S285 | Sugiyama | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P62333 | PSMC6 | S123 | Sugiyama | 26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| Q00610 | CLTC | S1483 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| P22314 | UBA1 | S1020 | Sugiyama | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P08253 | MMP2 | S160 | EPSD|PSP | 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] | Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION: PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.; FUNCTION: [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways. |
| Q9Y3P9 | RABGAP1 | S932 | Sugiyama | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| P26038 | MSN | S440 | Sugiyama | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
| P62714 | PPP2CB | S212 | Sugiyama | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}. |
| P67775 | PPP2CA | S212 | Sugiyama | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}. |
| Q8WZ42 | TTN | S20761 | Sugiyama | Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) | Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. {ECO:0000269|PubMed:11846417, ECO:0000269|PubMed:9804419}. |
| Q6ULP2 | AFTPH | S584 | Sugiyama | Aftiphilin | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
| Q16762 | TST | S202 | Sugiyama | Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) | Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA. {ECO:0000250, ECO:0000269|PubMed:20663881, ECO:0000269|PubMed:21685364}. |
| P38646 | HSPA9 | S473 | Sugiyama | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P08151 | GLI1 | S523 | GPS6 | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| Q9BRK5 | SDF4 | S343 | Sugiyama | 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. |
| O15355 | PPM1G | S354 | Sugiyama | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| Q6XUX3 | DSTYK | S66 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| P30086 | PEBP1 | S142 | Sugiyama | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| Q9HBH9 | MKNK2 | S394 | Sugiyama | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
| P10646 | TFPI | S237 | Sugiyama | Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) | Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. {ECO:0000269|PubMed:20676107}. |
| Q9UHD2 | TBK1 | S151 | Sugiyama | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UK32 | RPS6KA6 | S19 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| P00966 | ASS1 | S92 | Sugiyama | Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) | One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. {ECO:0000305|PubMed:18473344, ECO:0000305|PubMed:27287393, ECO:0000305|PubMed:8792870}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-437239 | Recycling pathway of L1 | 4.137195e-08 | 7.383 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.642983e-08 | 7.333 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 4.271526e-07 | 6.369 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 5.520089e-07 | 6.258 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 8.918372e-07 | 6.050 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.529606e-06 | 5.597 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.352808e-06 | 5.475 |
| R-HSA-983189 | Kinesins | 2.715481e-06 | 5.566 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.304985e-06 | 5.481 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.741534e-06 | 5.427 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.824158e-06 | 5.317 |
| R-HSA-190828 | Gap junction trafficking | 4.855565e-06 | 5.314 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 5.144661e-06 | 5.289 |
| R-HSA-373760 | L1CAM interactions | 6.570026e-06 | 5.182 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 8.285532e-06 | 5.082 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.084773e-06 | 5.042 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 9.505905e-06 | 5.022 |
| R-HSA-157858 | Gap junction trafficking and regulation | 8.764314e-06 | 5.057 |
| R-HSA-422475 | Axon guidance | 9.388101e-06 | 5.027 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.113233e-05 | 4.953 |
| R-HSA-69275 | G2/M Transition | 1.218863e-05 | 4.914 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.340377e-05 | 4.873 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.267737e-05 | 4.897 |
| R-HSA-190861 | Gap junction assembly | 1.472290e-05 | 4.832 |
| R-HSA-9833482 | PKR-mediated signaling | 1.730640e-05 | 4.762 |
| R-HSA-9675108 | Nervous system development | 2.380529e-05 | 4.623 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.478410e-05 | 4.606 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.191500e-05 | 4.496 |
| R-HSA-9646399 | Aggrephagy | 3.141755e-05 | 4.503 |
| R-HSA-429947 | Deadenylation of mRNA | 4.208823e-05 | 4.376 |
| R-HSA-68882 | Mitotic Anaphase | 4.735612e-05 | 4.325 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.928949e-05 | 4.307 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 5.397449e-05 | 4.268 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.397906e-05 | 4.194 |
| R-HSA-8953854 | Metabolism of RNA | 6.967971e-05 | 4.157 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 7.433625e-05 | 4.129 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 9.838967e-05 | 4.007 |
| R-HSA-9020591 | Interleukin-12 signaling | 9.992017e-05 | 4.000 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.897979e-05 | 4.004 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.141295e-04 | 3.943 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.327571e-04 | 3.877 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.547252e-04 | 3.810 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.148988e-04 | 3.668 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.246834e-04 | 3.648 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.246834e-04 | 3.648 |
| R-HSA-9663891 | Selective autophagy | 2.390984e-04 | 3.621 |
| R-HSA-391251 | Protein folding | 3.227726e-04 | 3.491 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.381812e-04 | 3.471 |
| R-HSA-68877 | Mitotic Prometaphase | 3.652753e-04 | 3.437 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.788352e-04 | 3.422 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.284697e-04 | 3.368 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.176566e-04 | 3.379 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.110154e-04 | 3.292 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 5.137798e-04 | 3.289 |
| R-HSA-72172 | mRNA Splicing | 5.577973e-04 | 3.254 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.817571e-04 | 3.235 |
| R-HSA-913531 | Interferon Signaling | 5.932443e-04 | 3.227 |
| R-HSA-5620924 | Intraflagellar transport | 7.358216e-04 | 3.133 |
| R-HSA-202670 | ERKs are inactivated | 9.256221e-04 | 3.034 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 1.028926e-03 | 2.988 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.427762e-03 | 2.845 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.458397e-03 | 2.836 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.514993e-03 | 2.820 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.526467e-03 | 2.816 |
| R-HSA-68886 | M Phase | 1.745838e-03 | 2.758 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.874293e-03 | 2.727 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 1.841718e-03 | 2.735 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.837597e-03 | 2.736 |
| R-HSA-1266738 | Developmental Biology | 2.136222e-03 | 2.670 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.272857e-03 | 2.485 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.929481e-03 | 2.533 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.213330e-03 | 2.493 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.188527e-03 | 2.496 |
| R-HSA-449147 | Signaling by Interleukins | 3.119119e-03 | 2.506 |
| R-HSA-198753 | ERK/MAPK targets | 4.362802e-03 | 2.360 |
| R-HSA-1632852 | Macroautophagy | 3.879339e-03 | 2.411 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.027405e-03 | 2.395 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 4.600991e-03 | 2.337 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.890995e-03 | 2.311 |
| R-HSA-166208 | mTORC1-mediated signalling | 5.351493e-03 | 2.272 |
| R-HSA-9612973 | Autophagy | 6.469414e-03 | 2.189 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 7.073178e-03 | 2.150 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 7.073178e-03 | 2.150 |
| R-HSA-72649 | Translation initiation complex formation | 7.826968e-03 | 2.106 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 8.489398e-03 | 2.071 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 8.719549e-03 | 2.060 |
| R-HSA-9764561 | Regulation of CDH1 Function | 9.189754e-03 | 2.037 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 9.813520e-03 | 2.008 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.999612e-03 | 2.046 |
| R-HSA-199991 | Membrane Trafficking | 9.829666e-03 | 2.007 |
| R-HSA-1640170 | Cell Cycle | 9.960235e-03 | 2.002 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.002154e-02 | 1.999 |
| R-HSA-186712 | Regulation of beta-cell development | 1.017906e-02 | 1.992 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.222569e-02 | 1.913 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.342146e-02 | 1.872 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.342146e-02 | 1.872 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.342146e-02 | 1.872 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.528331e-02 | 1.816 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.528331e-02 | 1.816 |
| R-HSA-4839744 | Signaling by APC mutants | 1.342146e-02 | 1.872 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.528331e-02 | 1.816 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.528331e-02 | 1.816 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.528331e-02 | 1.816 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.528331e-02 | 1.816 |
| R-HSA-162582 | Signal Transduction | 1.345598e-02 | 1.871 |
| R-HSA-5617833 | Cilium Assembly | 1.633756e-02 | 1.787 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.684936e-02 | 1.773 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.693872e-02 | 1.771 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.693872e-02 | 1.771 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.724922e-02 | 1.763 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.724922e-02 | 1.763 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.724922e-02 | 1.763 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.724922e-02 | 1.763 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.724922e-02 | 1.763 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.735738e-02 | 1.761 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.829658e-02 | 1.738 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.374338e-02 | 1.624 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.004998e-02 | 1.698 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.004998e-02 | 1.698 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.374338e-02 | 1.624 |
| R-HSA-4086400 | PCP/CE pathway | 2.309204e-02 | 1.637 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.374338e-02 | 1.624 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.018877e-02 | 1.695 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.138296e-02 | 1.670 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.917378e-02 | 1.717 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.375792e-02 | 1.624 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.375792e-02 | 1.624 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.395315e-02 | 1.621 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.395315e-02 | 1.621 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.484469e-02 | 1.605 |
| R-HSA-165159 | MTOR signalling | 2.501860e-02 | 1.602 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.609784e-02 | 1.583 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 2.609784e-02 | 1.583 |
| R-HSA-8854214 | TBC/RABGAPs | 2.631474e-02 | 1.580 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.764627e-02 | 1.558 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.764627e-02 | 1.558 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.901313e-02 | 1.537 |
| R-HSA-75153 | Apoptotic execution phase | 3.041524e-02 | 1.517 |
| R-HSA-69206 | G1/S Transition | 3.148737e-02 | 1.502 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.185251e-02 | 1.497 |
| R-HSA-3928664 | Ephrin signaling | 3.369375e-02 | 1.472 |
| R-HSA-9831926 | Nephron development | 3.369375e-02 | 1.472 |
| R-HSA-432142 | Platelet sensitization by LDL | 3.369375e-02 | 1.472 |
| R-HSA-5619056 | Defective HK1 causes hexokinase deficiency (HK deficiency) | 3.657786e-02 | 1.437 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 3.657786e-02 | 1.437 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.956175e-02 | 1.403 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.917642e-02 | 1.407 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.917642e-02 | 1.407 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.956175e-02 | 1.403 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.120711e-02 | 1.385 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.288657e-02 | 1.368 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.459991e-02 | 1.351 |
| R-HSA-9766229 | Degradation of CDH1 | 3.483204e-02 | 1.458 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.639484e-02 | 1.439 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.795067e-02 | 1.421 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.045939e-02 | 1.393 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.507216e-02 | 1.346 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.110246e-02 | 1.386 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.483204e-02 | 1.458 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.483204e-02 | 1.458 |
| R-HSA-2262752 | Cellular responses to stress | 3.499060e-02 | 1.456 |
| R-HSA-109582 | Hemostasis | 4.429439e-02 | 1.354 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.634693e-02 | 1.334 |
| R-HSA-195721 | Signaling by WNT | 4.645116e-02 | 1.333 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.674764e-02 | 1.330 |
| R-HSA-6803529 | FGFR2 alternative splicing | 4.798047e-02 | 1.319 |
| R-HSA-190236 | Signaling by FGFR | 4.805394e-02 | 1.318 |
| R-HSA-198765 | Signalling to ERK5 | 4.847218e-02 | 1.315 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 4.847218e-02 | 1.315 |
| R-HSA-9609690 | HCMV Early Events | 5.315039e-02 | 1.274 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.488267e-02 | 1.261 |
| R-HSA-450294 | MAP kinase activation | 5.557902e-02 | 1.255 |
| R-HSA-68911 | G2 Phase | 8.328552e-02 | 1.079 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 8.531817e-02 | 1.069 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.354560e-02 | 1.197 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.374132e-02 | 1.196 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 8.328552e-02 | 1.079 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 8.328552e-02 | 1.079 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 7.866967e-02 | 1.104 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 6.022038e-02 | 1.220 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 6.745481e-02 | 1.171 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 7.091779e-02 | 1.149 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 7.801205e-02 | 1.108 |
| R-HSA-4791275 | Signaling by WNT in cancer | 8.163955e-02 | 1.088 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 8.531817e-02 | 1.069 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 5.742600e-02 | 1.241 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 8.094799e-02 | 1.092 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 6.022038e-02 | 1.220 |
| R-HSA-205025 | NADE modulates death signalling | 7.182424e-02 | 1.144 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 8.328552e-02 | 1.079 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 8.163955e-02 | 1.088 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.374132e-02 | 1.196 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 6.405051e-02 | 1.193 |
| R-HSA-109581 | Apoptosis | 7.529804e-02 | 1.123 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 6.022038e-02 | 1.220 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 8.328552e-02 | 1.079 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 7.642012e-02 | 1.117 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 7.642012e-02 | 1.117 |
| R-HSA-1538133 | G0 and Early G1 | 8.163955e-02 | 1.088 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.752308e-02 | 1.240 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 7.419967e-02 | 1.130 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.345920e-02 | 1.198 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 8.094799e-02 | 1.092 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.005736e-02 | 1.221 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.225850e-02 | 1.206 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.495998e-02 | 1.125 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.685008e-02 | 1.175 |
| R-HSA-446728 | Cell junction organization | 8.001759e-02 | 1.097 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.685008e-02 | 1.175 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.922495e-02 | 1.227 |
| R-HSA-140834 | Extrinsic Pathway of Fibrin Clot Formation | 7.182424e-02 | 1.144 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.604421e-02 | 1.180 |
| R-HSA-448424 | Interleukin-17 signaling | 7.419967e-02 | 1.130 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.178962e-02 | 1.087 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 6.405051e-02 | 1.193 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.949905e-02 | 1.225 |
| R-HSA-180024 | DARPP-32 events | 7.091779e-02 | 1.149 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 7.866967e-02 | 1.104 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.071074e-02 | 1.217 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 6.070690e-02 | 1.217 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.891592e-02 | 1.051 |
| R-HSA-390522 | Striated Muscle Contraction | 8.904610e-02 | 1.050 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 8.904610e-02 | 1.050 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 9.258805e-02 | 1.033 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 9.274786e-02 | 1.033 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 9.274786e-02 | 1.033 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.274786e-02 | 1.033 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 9.282159e-02 | 1.032 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 9.282159e-02 | 1.032 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 9.282159e-02 | 1.032 |
| R-HSA-5673000 | RAF activation | 9.282159e-02 | 1.032 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 9.460599e-02 | 1.024 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.168313e-01 | 0.932 |
| R-HSA-444257 | RSK activation | 1.277395e-01 | 0.894 |
| R-HSA-196025 | Formation of annular gap junctions | 1.277395e-01 | 0.894 |
| R-HSA-190873 | Gap junction degradation | 1.385137e-01 | 0.859 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.385137e-01 | 0.859 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.491554e-01 | 0.826 |
| R-HSA-72187 | mRNA 3'-end processing | 1.714914e-01 | 0.766 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.130209e-01 | 0.947 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.130209e-01 | 0.947 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 1.549262e-01 | 0.810 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.491554e-01 | 0.826 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.596664e-01 | 0.797 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.385137e-01 | 0.859 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.168313e-01 | 0.932 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.277395e-01 | 0.894 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.700481e-01 | 0.769 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.044163e-01 | 0.981 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.245373e-01 | 0.905 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.454904e-01 | 0.837 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.454904e-01 | 0.837 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.454904e-01 | 0.837 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.608440e-01 | 0.794 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.104015e-01 | 0.957 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 9.460599e-02 | 1.024 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.057873e-01 | 0.976 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.385137e-01 | 0.859 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.491554e-01 | 0.826 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.803022e-01 | 0.744 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 1.005084e-01 | 0.998 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.454904e-01 | 0.837 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.454904e-01 | 0.837 |
| R-HSA-390696 | Adrenoceptors | 1.277395e-01 | 0.894 |
| R-HSA-8963888 | Chylomicron assembly | 1.596664e-01 | 0.797 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.700481e-01 | 0.769 |
| R-HSA-69242 | S Phase | 1.532759e-01 | 0.815 |
| R-HSA-8964041 | LDL remodeling | 1.168313e-01 | 0.932 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 9.664291e-02 | 1.015 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 9.664291e-02 | 1.015 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.245373e-01 | 0.905 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.497654e-01 | 0.825 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.758984e-01 | 0.755 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 9.460599e-02 | 1.024 |
| R-HSA-4641258 | Degradation of DVL | 1.044163e-01 | 0.981 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.491554e-01 | 0.826 |
| R-HSA-446205 | Synthesis of GDP-mannose | 1.803022e-01 | 0.744 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.005084e-01 | 0.998 |
| R-HSA-4641257 | Degradation of AXIN | 1.044163e-01 | 0.981 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.044163e-01 | 0.981 |
| R-HSA-5357801 | Programmed Cell Death | 1.501457e-01 | 0.823 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.803022e-01 | 0.744 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 9.664291e-02 | 1.015 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 9.460599e-02 | 1.024 |
| R-HSA-8866423 | VLDL assembly | 1.057873e-01 | 0.976 |
| R-HSA-169911 | Regulation of Apoptosis | 9.664291e-02 | 1.015 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.245373e-01 | 0.905 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.245373e-01 | 0.905 |
| R-HSA-9907900 | Proteasome assembly | 1.370207e-01 | 0.863 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.627357e-01 | 0.789 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.714914e-01 | 0.766 |
| R-HSA-114608 | Platelet degranulation | 1.020783e-01 | 0.991 |
| R-HSA-5654743 | Signaling by FGFR4 | 1.328288e-01 | 0.877 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 9.664291e-02 | 1.015 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.163788e-01 | 0.934 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 1.204407e-01 | 0.919 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.204407e-01 | 0.919 |
| R-HSA-5654741 | Signaling by FGFR3 | 1.412417e-01 | 0.850 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.313894e-01 | 0.881 |
| R-HSA-69239 | Synthesis of DNA | 1.851630e-01 | 0.732 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 1.168313e-01 | 0.932 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.123531e-01 | 0.949 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.123531e-01 | 0.949 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.328288e-01 | 0.877 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.160818e-01 | 0.935 |
| R-HSA-418990 | Adherens junctions interactions | 1.760993e-01 | 0.754 |
| R-HSA-1474244 | Extracellular matrix organization | 1.491566e-01 | 0.826 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.851630e-01 | 0.732 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.851630e-01 | 0.732 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.412417e-01 | 0.850 |
| R-HSA-69481 | G2/M Checkpoints | 1.020783e-01 | 0.991 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.328784e-01 | 0.877 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.370207e-01 | 0.863 |
| R-HSA-69236 | G1 Phase | 1.370207e-01 | 0.863 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.244425e-01 | 0.905 |
| R-HSA-1500931 | Cell-Cell communication | 1.272962e-01 | 0.895 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.385137e-01 | 0.859 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.163788e-01 | 0.934 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.204407e-01 | 0.919 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.412417e-01 | 0.850 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.540654e-01 | 0.812 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.671035e-01 | 0.777 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.087392e-01 | 0.964 |
| R-HSA-1280218 | Adaptive Immune System | 1.759036e-01 | 0.755 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.412417e-01 | 0.850 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.412417e-01 | 0.850 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.532759e-01 | 0.815 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.040284e-01 | 0.983 |
| R-HSA-70171 | Glycolysis | 1.608440e-01 | 0.794 |
| R-HSA-9020933 | Interleukin-23 signaling | 1.277395e-01 | 0.894 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.700481e-01 | 0.769 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.671035e-01 | 0.777 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.803022e-01 | 0.744 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.758984e-01 | 0.755 |
| R-HSA-8983711 | OAS antiviral response | 1.803022e-01 | 0.744 |
| R-HSA-69541 | Stabilization of p53 | 1.123531e-01 | 0.949 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 1.714914e-01 | 0.766 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.882694e-01 | 0.725 |
| R-HSA-168256 | Immune System | 1.036263e-01 | 0.985 |
| R-HSA-9609646 | HCMV Infection | 1.219087e-01 | 0.914 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.578764e-01 | 0.802 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.549262e-01 | 0.810 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.549262e-01 | 0.810 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.549262e-01 | 0.810 |
| R-HSA-166520 | Signaling by NTRKs | 1.532759e-01 | 0.815 |
| R-HSA-9824272 | Somitogenesis | 1.412417e-01 | 0.850 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.818985e-01 | 0.740 |
| R-HSA-73887 | Death Receptor Signaling | 1.673665e-01 | 0.776 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.104015e-01 | 0.957 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.444031e-01 | 0.840 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.602636e-01 | 0.795 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.881685e-01 | 0.725 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.584272e-02 | 1.018 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.892223e-01 | 0.723 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.892223e-01 | 0.723 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.904302e-01 | 0.720 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.904302e-01 | 0.720 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.913893e-01 | 0.718 |
| R-HSA-72766 | Translation | 1.990849e-01 | 0.701 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 2.004337e-01 | 0.698 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.004337e-01 | 0.698 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 2.004337e-01 | 0.698 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.004337e-01 | 0.698 |
| R-HSA-180786 | Extension of Telomeres | 2.026781e-01 | 0.693 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.039965e-01 | 0.690 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.071784e-01 | 0.684 |
| R-HSA-351202 | Metabolism of polyamines | 2.071880e-01 | 0.684 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.103143e-01 | 0.677 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.103143e-01 | 0.677 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.103143e-01 | 0.677 |
| R-HSA-73942 | DNA Damage Reversal | 2.103143e-01 | 0.677 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.117084e-01 | 0.674 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.117084e-01 | 0.674 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.117084e-01 | 0.674 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.135757e-01 | 0.670 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.167903e-01 | 0.664 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 2.200733e-01 | 0.657 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.200733e-01 | 0.657 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.200733e-01 | 0.657 |
| R-HSA-5635838 | Activation of SMO | 2.200733e-01 | 0.657 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 2.200733e-01 | 0.657 |
| R-HSA-373755 | Semaphorin interactions | 2.207776e-01 | 0.656 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 2.207776e-01 | 0.656 |
| R-HSA-70326 | Glucose metabolism | 2.232500e-01 | 0.651 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.297123e-01 | 0.639 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.297123e-01 | 0.639 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.297123e-01 | 0.639 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.297123e-01 | 0.639 |
| R-HSA-964975 | Vitamin B6 activation to pyridoxal phosphate | 2.297123e-01 | 0.639 |
| R-HSA-70370 | Galactose catabolism | 2.297123e-01 | 0.639 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.297476e-01 | 0.639 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.297476e-01 | 0.639 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.298783e-01 | 0.639 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 2.344383e-01 | 0.630 |
| R-HSA-9830369 | Kidney development | 2.390036e-01 | 0.622 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 2.392328e-01 | 0.621 |
| R-HSA-2028269 | Signaling by Hippo | 2.392328e-01 | 0.621 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.392328e-01 | 0.621 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.395592e-01 | 0.621 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.395592e-01 | 0.621 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.481468e-01 | 0.605 |
| R-HSA-421270 | Cell-cell junction organization | 2.484856e-01 | 0.605 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.486361e-01 | 0.604 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.486361e-01 | 0.604 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.486361e-01 | 0.604 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.486361e-01 | 0.604 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.527231e-01 | 0.597 |
| R-HSA-194138 | Signaling by VEGF | 2.527487e-01 | 0.597 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.573016e-01 | 0.590 |
| R-HSA-5688426 | Deubiquitination | 2.577577e-01 | 0.589 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.579239e-01 | 0.589 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.579239e-01 | 0.589 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.579239e-01 | 0.589 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.579239e-01 | 0.589 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.579239e-01 | 0.589 |
| R-HSA-449836 | Other interleukin signaling | 2.579239e-01 | 0.589 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.579239e-01 | 0.589 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 2.618814e-01 | 0.582 |
| R-HSA-112316 | Neuronal System | 2.641695e-01 | 0.578 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.651063e-01 | 0.577 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.652201e-01 | 0.576 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.670974e-01 | 0.573 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.670974e-01 | 0.573 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.670974e-01 | 0.573 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.670974e-01 | 0.573 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.670974e-01 | 0.573 |
| R-HSA-3322077 | Glycogen synthesis | 2.670974e-01 | 0.573 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.710424e-01 | 0.567 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.710424e-01 | 0.567 |
| R-HSA-8852135 | Protein ubiquitination | 2.756221e-01 | 0.560 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.756221e-01 | 0.560 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.761580e-01 | 0.559 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 2.794162e-01 | 0.554 |
| R-HSA-9909396 | Circadian clock | 2.794162e-01 | 0.554 |
| R-HSA-5689603 | UCH proteinases | 2.802003e-01 | 0.553 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.851072e-01 | 0.545 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.851072e-01 | 0.545 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.851072e-01 | 0.545 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.851072e-01 | 0.545 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.851072e-01 | 0.545 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.884270e-01 | 0.540 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.893500e-01 | 0.539 |
| R-HSA-216083 | Integrin cell surface interactions | 2.893500e-01 | 0.539 |
| R-HSA-5619084 | ABC transporter disorders | 2.893500e-01 | 0.539 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 2.939463e-01 | 0.532 |
| R-HSA-8964038 | LDL clearance | 2.939463e-01 | 0.532 |
| R-HSA-163685 | Integration of energy metabolism | 2.962207e-01 | 0.528 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.984863e-01 | 0.525 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.026766e-01 | 0.519 |
| R-HSA-9948299 | Ribosome-associated quality control | 3.029616e-01 | 0.519 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.030478e-01 | 0.518 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 3.076043e-01 | 0.512 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.112996e-01 | 0.507 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 3.112996e-01 | 0.507 |
| R-HSA-9865881 | Complex III assembly | 3.112996e-01 | 0.507 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 3.121550e-01 | 0.506 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.166995e-01 | 0.499 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.198164e-01 | 0.495 |
| R-HSA-9620244 | Long-term potentiation | 3.198164e-01 | 0.495 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.198164e-01 | 0.495 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.198164e-01 | 0.495 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.198164e-01 | 0.495 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.221524e-01 | 0.492 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.257675e-01 | 0.487 |
| R-HSA-397014 | Muscle contraction | 3.260322e-01 | 0.487 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.282284e-01 | 0.484 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.282284e-01 | 0.484 |
| R-HSA-70635 | Urea cycle | 3.282284e-01 | 0.484 |
| R-HSA-9845614 | Sphingolipid catabolism | 3.282284e-01 | 0.484 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.288282e-01 | 0.483 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.302900e-01 | 0.481 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.365369e-01 | 0.473 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.365369e-01 | 0.473 |
| R-HSA-8949613 | Cristae formation | 3.365369e-01 | 0.473 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.365369e-01 | 0.473 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.365369e-01 | 0.473 |
| R-HSA-264876 | Insulin processing | 3.365369e-01 | 0.473 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.438057e-01 | 0.464 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.447432e-01 | 0.463 |
| R-HSA-5620971 | Pyroptosis | 3.447432e-01 | 0.463 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.447432e-01 | 0.463 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.447432e-01 | 0.463 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.468612e-01 | 0.460 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.468612e-01 | 0.460 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.482921e-01 | 0.458 |
| R-HSA-202424 | Downstream TCR signaling | 3.482921e-01 | 0.458 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.527683e-01 | 0.453 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.528484e-01 | 0.452 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 3.528484e-01 | 0.452 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.528484e-01 | 0.452 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.536056e-01 | 0.451 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.536056e-01 | 0.451 |
| R-HSA-69306 | DNA Replication | 3.569749e-01 | 0.447 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.572340e-01 | 0.447 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.603420e-01 | 0.443 |
| R-HSA-9008059 | Interleukin-37 signaling | 3.608539e-01 | 0.443 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 3.616885e-01 | 0.442 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 3.661317e-01 | 0.436 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.687608e-01 | 0.433 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.687608e-01 | 0.433 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.737831e-01 | 0.427 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 3.765704e-01 | 0.424 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.793886e-01 | 0.421 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.837822e-01 | 0.416 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.842839e-01 | 0.415 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.842839e-01 | 0.415 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.842839e-01 | 0.415 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.842839e-01 | 0.415 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 3.842839e-01 | 0.415 |
| R-HSA-157579 | Telomere Maintenance | 3.881624e-01 | 0.411 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.919024e-01 | 0.407 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.919024e-01 | 0.407 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.919024e-01 | 0.407 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.994271e-01 | 0.399 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.994271e-01 | 0.399 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.994271e-01 | 0.399 |
| R-HSA-5205647 | Mitophagy | 3.994271e-01 | 0.399 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.012200e-01 | 0.397 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.055438e-01 | 0.392 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.068592e-01 | 0.391 |
| R-HSA-381042 | PERK regulates gene expression | 4.068592e-01 | 0.391 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.098526e-01 | 0.387 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.141997e-01 | 0.383 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.141997e-01 | 0.383 |
| R-HSA-8853659 | RET signaling | 4.141997e-01 | 0.383 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.141997e-01 | 0.383 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 4.141997e-01 | 0.383 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.170265e-01 | 0.380 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.184244e-01 | 0.378 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.184244e-01 | 0.378 |
| R-HSA-111885 | Opioid Signalling | 4.184244e-01 | 0.378 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.214498e-01 | 0.375 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.214498e-01 | 0.375 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.223732e-01 | 0.374 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.286107e-01 | 0.368 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 4.286107e-01 | 0.368 |
| R-HSA-418346 | Platelet homeostasis | 4.311634e-01 | 0.365 |
| R-HSA-71336 | Pentose phosphate pathway | 4.356833e-01 | 0.361 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.356833e-01 | 0.361 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.356833e-01 | 0.361 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.395739e-01 | 0.357 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.426689e-01 | 0.354 |
| R-HSA-451927 | Interleukin-2 family signaling | 4.426689e-01 | 0.354 |
| R-HSA-8982491 | Glycogen metabolism | 4.426689e-01 | 0.354 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.437537e-01 | 0.353 |
| R-HSA-202403 | TCR signaling | 4.479164e-01 | 0.349 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.485437e-01 | 0.348 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.495684e-01 | 0.347 |
| R-HSA-2559583 | Cellular Senescence | 4.496342e-01 | 0.347 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.563829e-01 | 0.341 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.563829e-01 | 0.341 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.563829e-01 | 0.341 |
| R-HSA-9824446 | Viral Infection Pathways | 4.578906e-01 | 0.339 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.631134e-01 | 0.334 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.631134e-01 | 0.334 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.631134e-01 | 0.334 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.643909e-01 | 0.333 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.751863e-01 | 0.323 |
| R-HSA-5683826 | Surfactant metabolism | 4.763268e-01 | 0.322 |
| R-HSA-375280 | Amine ligand-binding receptors | 4.763268e-01 | 0.322 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.828116e-01 | 0.316 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 4.828116e-01 | 0.316 |
| R-HSA-5693538 | Homology Directed Repair | 4.885538e-01 | 0.311 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.892165e-01 | 0.310 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.892165e-01 | 0.310 |
| R-HSA-9675135 | Diseases of DNA repair | 4.892165e-01 | 0.310 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 4.892165e-01 | 0.310 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.892165e-01 | 0.310 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.925148e-01 | 0.308 |
| R-HSA-68875 | Mitotic Prophase | 4.964565e-01 | 0.304 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.969407e-01 | 0.304 |
| R-HSA-3371556 | Cellular response to heat stress | 5.003788e-01 | 0.301 |
| R-HSA-73886 | Chromosome Maintenance | 5.003788e-01 | 0.301 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 5.017906e-01 | 0.299 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.081648e-01 | 0.294 |
| R-HSA-162909 | Host Interactions of HIV factors | 5.120281e-01 | 0.291 |
| R-HSA-912446 | Meiotic recombination | 5.200764e-01 | 0.284 |
| R-HSA-2514856 | The phototransduction cascade | 5.200764e-01 | 0.284 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.260221e-01 | 0.279 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.260221e-01 | 0.279 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.318944e-01 | 0.274 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.318944e-01 | 0.274 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.318944e-01 | 0.274 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.376944e-01 | 0.269 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.385102e-01 | 0.269 |
| R-HSA-392499 | Metabolism of proteins | 5.444562e-01 | 0.264 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.490806e-01 | 0.260 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.490806e-01 | 0.260 |
| R-HSA-5578775 | Ion homeostasis | 5.490806e-01 | 0.260 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.490806e-01 | 0.260 |
| R-HSA-75893 | TNF signaling | 5.490806e-01 | 0.260 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.490806e-01 | 0.260 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.510137e-01 | 0.259 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.546687e-01 | 0.256 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.601878e-01 | 0.252 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.601878e-01 | 0.252 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.601878e-01 | 0.252 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.648702e-01 | 0.248 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.710227e-01 | 0.243 |
| R-HSA-379724 | tRNA Aminoacylation | 5.710227e-01 | 0.243 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.710227e-01 | 0.243 |
| R-HSA-9679506 | SARS-CoV Infections | 5.760330e-01 | 0.240 |
| R-HSA-1442490 | Collagen degradation | 5.763402e-01 | 0.239 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.780944e-01 | 0.238 |
| R-HSA-6807070 | PTEN Regulation | 5.780944e-01 | 0.238 |
| R-HSA-1268020 | Mitochondrial protein import | 5.815921e-01 | 0.235 |
| R-HSA-9707616 | Heme signaling | 5.815921e-01 | 0.235 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.815921e-01 | 0.235 |
| R-HSA-186797 | Signaling by PDGF | 5.815921e-01 | 0.235 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.867791e-01 | 0.232 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.867791e-01 | 0.232 |
| R-HSA-6799198 | Complex I biogenesis | 5.867791e-01 | 0.232 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.908783e-01 | 0.229 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.919022e-01 | 0.228 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.952529e-01 | 0.225 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.986217e-01 | 0.223 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.019596e-01 | 0.220 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.068954e-01 | 0.217 |
| R-HSA-72312 | rRNA processing | 6.071733e-01 | 0.217 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.117703e-01 | 0.213 |
| R-HSA-5218859 | Regulated Necrosis | 6.117703e-01 | 0.213 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.117703e-01 | 0.213 |
| R-HSA-597592 | Post-translational protein modification | 6.132837e-01 | 0.212 |
| R-HSA-9758941 | Gastrulation | 6.151511e-01 | 0.211 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.213403e-01 | 0.207 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.213403e-01 | 0.207 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.260370e-01 | 0.203 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.260370e-01 | 0.203 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.279976e-01 | 0.202 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.352571e-01 | 0.197 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.352571e-01 | 0.197 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.397819e-01 | 0.194 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.397819e-01 | 0.194 |
| R-HSA-380287 | Centrosome maturation | 6.442509e-01 | 0.191 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.442509e-01 | 0.191 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.460030e-01 | 0.190 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.486648e-01 | 0.188 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.573296e-01 | 0.182 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.573296e-01 | 0.182 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.599131e-01 | 0.181 |
| R-HSA-9659379 | Sensory processing of sound | 6.615820e-01 | 0.179 |
| R-HSA-2408522 | Selenoamino acid metabolism | 6.616115e-01 | 0.179 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.657819e-01 | 0.177 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.740266e-01 | 0.171 |
| R-HSA-72306 | tRNA processing | 6.817120e-01 | 0.166 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.820690e-01 | 0.166 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.843625e-01 | 0.165 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.845029e-01 | 0.165 |
| R-HSA-1500620 | Meiosis | 6.860158e-01 | 0.164 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.872738e-01 | 0.163 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.899139e-01 | 0.161 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 6.937638e-01 | 0.159 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 6.937638e-01 | 0.159 |
| R-HSA-73894 | DNA Repair | 6.966016e-01 | 0.157 |
| R-HSA-156902 | Peptide chain elongation | 7.013215e-01 | 0.154 |
| R-HSA-168255 | Influenza Infection | 7.061170e-01 | 0.151 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.069369e-01 | 0.151 |
| R-HSA-6798695 | Neutrophil degranulation | 7.103814e-01 | 0.149 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.123115e-01 | 0.147 |
| R-HSA-381070 | IRE1alpha activates chaperones | 7.158847e-01 | 0.145 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.194137e-01 | 0.143 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.228991e-01 | 0.141 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.263414e-01 | 0.139 |
| R-HSA-1474290 | Collagen formation | 7.263414e-01 | 0.139 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.297412e-01 | 0.137 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.297412e-01 | 0.137 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.330989e-01 | 0.135 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.330989e-01 | 0.135 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.364151e-01 | 0.133 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.386091e-01 | 0.132 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.461198e-01 | 0.127 |
| R-HSA-74160 | Gene expression (Transcription) | 7.506908e-01 | 0.125 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.523912e-01 | 0.124 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.523912e-01 | 0.124 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.554689e-01 | 0.122 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.554689e-01 | 0.122 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.570510e-01 | 0.121 |
| R-HSA-192823 | Viral mRNA Translation | 7.585085e-01 | 0.120 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.615105e-01 | 0.118 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.636731e-01 | 0.117 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.644753e-01 | 0.117 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.644753e-01 | 0.117 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.674035e-01 | 0.115 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.731517e-01 | 0.112 |
| R-HSA-8951664 | Neddylation | 8.020876e-01 | 0.096 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.047902e-01 | 0.094 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.047902e-01 | 0.094 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.084249e-01 | 0.092 |
| R-HSA-162906 | HIV Infection | 8.130198e-01 | 0.090 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.147888e-01 | 0.089 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.182822e-01 | 0.087 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.211759e-01 | 0.086 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.256009e-01 | 0.083 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.256009e-01 | 0.083 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.256009e-01 | 0.083 |
| R-HSA-8939211 | ESR-mediated signaling | 8.300510e-01 | 0.081 |
| R-HSA-157118 | Signaling by NOTCH | 8.348824e-01 | 0.078 |
| R-HSA-1474165 | Reproduction | 8.382328e-01 | 0.077 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.387448e-01 | 0.076 |
| R-HSA-5576891 | Cardiac conduction | 8.402478e-01 | 0.076 |
| R-HSA-9843745 | Adipogenesis | 8.402478e-01 | 0.076 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 8.402478e-01 | 0.076 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.518237e-01 | 0.070 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.560438e-01 | 0.068 |
| R-HSA-9664407 | Parasite infection | 8.590733e-01 | 0.066 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.590733e-01 | 0.066 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.590733e-01 | 0.066 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.608298e-01 | 0.065 |
| R-HSA-168249 | Innate Immune System | 8.639393e-01 | 0.064 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.642779e-01 | 0.063 |
| R-HSA-5663205 | Infectious disease | 8.644759e-01 | 0.063 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.662680e-01 | 0.062 |
| R-HSA-2187338 | Visual phototransduction | 8.725306e-01 | 0.059 |
| R-HSA-9609507 | Protein localization | 8.817773e-01 | 0.055 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.847087e-01 | 0.053 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 8.875678e-01 | 0.052 |
| R-HSA-9711097 | Cellular response to starvation | 8.889707e-01 | 0.051 |
| R-HSA-5619102 | SLC transporter disorders | 9.008389e-01 | 0.045 |
| R-HSA-418555 | G alpha (s) signalling events | 9.068776e-01 | 0.042 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.103238e-01 | 0.041 |
| R-HSA-611105 | Respiratory electron transport | 9.147220e-01 | 0.039 |
| R-HSA-3781865 | Diseases of glycosylation | 9.209201e-01 | 0.036 |
| R-HSA-983712 | Ion channel transport | 9.257412e-01 | 0.034 |
| R-HSA-212436 | Generic Transcription Pathway | 9.305451e-01 | 0.031 |
| R-HSA-388396 | GPCR downstream signalling | 9.328581e-01 | 0.030 |
| R-HSA-428157 | Sphingolipid metabolism | 9.361518e-01 | 0.029 |
| R-HSA-6805567 | Keratinization | 9.407988e-01 | 0.027 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.523577e-01 | 0.021 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.528556e-01 | 0.021 |
| R-HSA-1643685 | Disease | 9.551793e-01 | 0.020 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.599528e-01 | 0.018 |
| R-HSA-372790 | Signaling by GPCR | 9.640653e-01 | 0.016 |
| R-HSA-4839726 | Chromatin organization | 9.655833e-01 | 0.015 |
| R-HSA-418594 | G alpha (i) signalling events | 9.704576e-01 | 0.013 |
| R-HSA-416476 | G alpha (q) signalling events | 9.715261e-01 | 0.013 |
| R-HSA-9658195 | Leishmania infection | 9.770357e-01 | 0.010 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.770357e-01 | 0.010 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.892694e-01 | 0.005 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.943206e-01 | 0.002 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.946029e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.954271e-01 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 9.964579e-01 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 9.995577e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999985e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.867 | 0.124 | 2 | 0.866 |
CDC7 |
0.860 | 0.139 | 1 | 0.842 |
CLK3 |
0.860 | 0.169 | 1 | 0.810 |
MOS |
0.856 | 0.162 | 1 | 0.858 |
IKKB |
0.856 | 0.019 | -2 | 0.750 |
PIM3 |
0.853 | 0.089 | -3 | 0.805 |
PRPK |
0.852 | -0.047 | -1 | 0.858 |
MTOR |
0.852 | -0.014 | 1 | 0.786 |
GCN2 |
0.852 | 0.004 | 2 | 0.772 |
DSTYK |
0.850 | 0.036 | 2 | 0.862 |
RAF1 |
0.850 | -0.021 | 1 | 0.823 |
NDR2 |
0.850 | 0.052 | -3 | 0.818 |
NEK6 |
0.848 | 0.095 | -2 | 0.820 |
NLK |
0.848 | 0.055 | 1 | 0.816 |
ERK5 |
0.847 | 0.067 | 1 | 0.784 |
GRK1 |
0.846 | 0.116 | -2 | 0.743 |
BMPR2 |
0.846 | -0.030 | -2 | 0.838 |
CAMK2G |
0.846 | -0.041 | 2 | 0.804 |
TBK1 |
0.846 | -0.081 | 1 | 0.725 |
CAMK1B |
0.846 | -0.014 | -3 | 0.831 |
PRKD1 |
0.845 | 0.067 | -3 | 0.770 |
IKKA |
0.845 | 0.044 | -2 | 0.733 |
PDHK4 |
0.844 | -0.210 | 1 | 0.826 |
IKKE |
0.844 | -0.075 | 1 | 0.712 |
KIS |
0.844 | 0.062 | 1 | 0.695 |
ULK2 |
0.844 | -0.065 | 2 | 0.750 |
MST4 |
0.843 | 0.052 | 2 | 0.817 |
GRK5 |
0.842 | -0.048 | -3 | 0.859 |
CDKL1 |
0.842 | -0.011 | -3 | 0.756 |
PRKD2 |
0.841 | 0.063 | -3 | 0.725 |
SKMLCK |
0.841 | 0.047 | -2 | 0.836 |
RSK2 |
0.841 | 0.031 | -3 | 0.731 |
RIPK3 |
0.841 | -0.050 | 3 | 0.659 |
ATR |
0.841 | -0.055 | 1 | 0.788 |
PIM1 |
0.841 | 0.073 | -3 | 0.748 |
WNK1 |
0.841 | -0.009 | -2 | 0.860 |
NEK7 |
0.840 | -0.048 | -3 | 0.840 |
HIPK4 |
0.840 | 0.056 | 1 | 0.761 |
GRK6 |
0.840 | 0.021 | 1 | 0.818 |
PKN3 |
0.839 | -0.020 | -3 | 0.782 |
PDHK1 |
0.839 | -0.172 | 1 | 0.812 |
NDR1 |
0.839 | -0.003 | -3 | 0.808 |
CHAK2 |
0.839 | -0.001 | -1 | 0.846 |
MLK1 |
0.839 | -0.051 | 2 | 0.779 |
SRPK1 |
0.838 | 0.021 | -3 | 0.705 |
BMPR1B |
0.838 | 0.147 | 1 | 0.804 |
AURC |
0.838 | 0.107 | -2 | 0.664 |
TGFBR2 |
0.838 | -0.035 | -2 | 0.726 |
NIK |
0.837 | -0.057 | -3 | 0.858 |
CAMLCK |
0.837 | -0.010 | -2 | 0.838 |
NUAK2 |
0.837 | -0.026 | -3 | 0.810 |
CDKL5 |
0.836 | 0.005 | -3 | 0.741 |
PKN2 |
0.836 | -0.004 | -3 | 0.812 |
MAPKAPK3 |
0.836 | 0.003 | -3 | 0.731 |
DAPK2 |
0.835 | -0.013 | -3 | 0.835 |
CDK8 |
0.834 | 0.041 | 1 | 0.672 |
LATS2 |
0.834 | 0.005 | -5 | 0.749 |
CAMK2D |
0.834 | -0.024 | -3 | 0.795 |
P70S6KB |
0.834 | 0.002 | -3 | 0.759 |
MAPKAPK2 |
0.834 | 0.016 | -3 | 0.690 |
P90RSK |
0.834 | -0.020 | -3 | 0.727 |
ICK |
0.834 | 0.014 | -3 | 0.794 |
RSK3 |
0.834 | -0.008 | -3 | 0.719 |
PKCD |
0.833 | 0.017 | 2 | 0.752 |
DYRK2 |
0.833 | 0.073 | 1 | 0.691 |
NEK9 |
0.832 | -0.061 | 2 | 0.802 |
AMPKA1 |
0.832 | -0.037 | -3 | 0.821 |
PKACG |
0.832 | 0.012 | -2 | 0.739 |
TGFBR1 |
0.832 | 0.073 | -2 | 0.730 |
HUNK |
0.832 | -0.134 | 2 | 0.803 |
MLK2 |
0.831 | -0.019 | 2 | 0.784 |
ULK1 |
0.831 | -0.148 | -3 | 0.803 |
JNK2 |
0.831 | 0.107 | 1 | 0.628 |
FAM20C |
0.831 | 0.017 | 2 | 0.576 |
ALK4 |
0.831 | 0.019 | -2 | 0.765 |
MASTL |
0.831 | -0.166 | -2 | 0.788 |
GRK4 |
0.830 | -0.092 | -2 | 0.763 |
MLK3 |
0.830 | 0.009 | 2 | 0.706 |
TSSK2 |
0.830 | -0.024 | -5 | 0.830 |
CAMK2B |
0.830 | 0.011 | 2 | 0.779 |
PAK6 |
0.830 | 0.097 | -2 | 0.720 |
PKR |
0.829 | 0.076 | 1 | 0.800 |
BCKDK |
0.829 | -0.156 | -1 | 0.772 |
WNK3 |
0.829 | -0.204 | 1 | 0.785 |
CDK19 |
0.829 | 0.041 | 1 | 0.640 |
CLK4 |
0.828 | 0.052 | -3 | 0.732 |
DLK |
0.828 | -0.145 | 1 | 0.802 |
JNK3 |
0.828 | 0.082 | 1 | 0.657 |
MNK2 |
0.828 | 0.052 | -2 | 0.790 |
PAK1 |
0.828 | 0.009 | -2 | 0.769 |
ANKRD3 |
0.827 | -0.117 | 1 | 0.826 |
MARK4 |
0.827 | -0.114 | 4 | 0.763 |
CDK1 |
0.827 | 0.058 | 1 | 0.632 |
IRE1 |
0.827 | -0.068 | 1 | 0.758 |
AMPKA2 |
0.827 | -0.034 | -3 | 0.788 |
TTBK2 |
0.827 | -0.128 | 2 | 0.689 |
CDK7 |
0.827 | 0.021 | 1 | 0.682 |
CDK5 |
0.827 | 0.064 | 1 | 0.700 |
P38A |
0.826 | 0.072 | 1 | 0.706 |
LATS1 |
0.826 | 0.034 | -3 | 0.842 |
CAMK4 |
0.826 | -0.063 | -3 | 0.790 |
GRK7 |
0.826 | 0.018 | 1 | 0.765 |
CLK2 |
0.825 | 0.100 | -3 | 0.711 |
ALK2 |
0.825 | 0.063 | -2 | 0.741 |
SRPK2 |
0.825 | -0.010 | -3 | 0.623 |
TSSK1 |
0.825 | -0.029 | -3 | 0.835 |
ATM |
0.825 | -0.057 | 1 | 0.737 |
CLK1 |
0.825 | 0.050 | -3 | 0.708 |
CAMK2A |
0.825 | -0.008 | 2 | 0.804 |
PLK1 |
0.825 | -0.060 | -2 | 0.760 |
RIPK1 |
0.825 | -0.180 | 1 | 0.785 |
ACVR2B |
0.824 | 0.045 | -2 | 0.732 |
AURB |
0.824 | 0.053 | -2 | 0.661 |
CDK18 |
0.824 | 0.056 | 1 | 0.620 |
PKACB |
0.824 | 0.055 | -2 | 0.676 |
ACVR2A |
0.824 | 0.015 | -2 | 0.719 |
RSK4 |
0.824 | 0.020 | -3 | 0.702 |
PAK3 |
0.824 | -0.043 | -2 | 0.770 |
MSK2 |
0.823 | -0.047 | -3 | 0.693 |
AURA |
0.823 | 0.057 | -2 | 0.629 |
P38B |
0.823 | 0.070 | 1 | 0.632 |
YSK4 |
0.823 | -0.065 | 1 | 0.758 |
PRKX |
0.822 | 0.080 | -3 | 0.658 |
SRPK3 |
0.822 | -0.035 | -3 | 0.677 |
BMPR1A |
0.822 | 0.119 | 1 | 0.793 |
NIM1 |
0.822 | -0.130 | 3 | 0.686 |
ERK1 |
0.822 | 0.052 | 1 | 0.633 |
MEK1 |
0.822 | -0.102 | 2 | 0.822 |
VRK2 |
0.822 | -0.098 | 1 | 0.844 |
PKCA |
0.822 | 0.007 | 2 | 0.687 |
CDK13 |
0.821 | 0.001 | 1 | 0.659 |
PRKD3 |
0.821 | -0.025 | -3 | 0.699 |
MNK1 |
0.821 | 0.035 | -2 | 0.795 |
NEK2 |
0.821 | -0.059 | 2 | 0.772 |
PKCG |
0.821 | -0.022 | 2 | 0.705 |
PKG2 |
0.820 | 0.033 | -2 | 0.685 |
P38G |
0.820 | 0.064 | 1 | 0.556 |
MELK |
0.820 | -0.064 | -3 | 0.766 |
DNAPK |
0.820 | -0.022 | 1 | 0.676 |
HIPK2 |
0.819 | 0.063 | 1 | 0.617 |
MSK1 |
0.819 | -0.005 | -3 | 0.702 |
AKT2 |
0.819 | 0.027 | -3 | 0.644 |
PKCB |
0.819 | -0.018 | 2 | 0.703 |
PERK |
0.819 | 0.007 | -2 | 0.786 |
CHK1 |
0.819 | -0.004 | -3 | 0.794 |
PRP4 |
0.819 | 0.041 | -3 | 0.746 |
MLK4 |
0.819 | -0.071 | 2 | 0.684 |
CDK3 |
0.818 | 0.066 | 1 | 0.583 |
PLK3 |
0.818 | -0.073 | 2 | 0.765 |
MYLK4 |
0.818 | -0.024 | -2 | 0.758 |
HIPK1 |
0.818 | 0.043 | 1 | 0.715 |
P38D |
0.817 | 0.089 | 1 | 0.584 |
SMG1 |
0.817 | -0.085 | 1 | 0.739 |
PHKG1 |
0.817 | -0.071 | -3 | 0.793 |
IRE2 |
0.817 | -0.101 | 2 | 0.701 |
SGK3 |
0.817 | 0.008 | -3 | 0.727 |
PKCZ |
0.817 | -0.031 | 2 | 0.740 |
PIM2 |
0.817 | 0.023 | -3 | 0.702 |
TLK2 |
0.817 | -0.059 | 1 | 0.742 |
DYRK4 |
0.817 | 0.067 | 1 | 0.627 |
NUAK1 |
0.817 | -0.090 | -3 | 0.757 |
GAK |
0.817 | 0.224 | 1 | 0.880 |
DRAK1 |
0.816 | -0.033 | 1 | 0.741 |
CDK2 |
0.816 | -0.010 | 1 | 0.705 |
CDK17 |
0.816 | 0.031 | 1 | 0.563 |
ERK2 |
0.816 | 0.010 | 1 | 0.668 |
PAK2 |
0.816 | -0.063 | -2 | 0.756 |
PKCH |
0.815 | -0.047 | 2 | 0.682 |
BRAF |
0.815 | -0.033 | -4 | 0.869 |
MPSK1 |
0.815 | 0.144 | 1 | 0.813 |
CHAK1 |
0.815 | -0.124 | 2 | 0.738 |
CK1E |
0.814 | 0.007 | -3 | 0.585 |
GRK2 |
0.814 | -0.055 | -2 | 0.670 |
HRI |
0.813 | -0.104 | -2 | 0.793 |
PINK1 |
0.813 | -0.068 | 1 | 0.806 |
MST3 |
0.813 | 0.022 | 2 | 0.807 |
CDK9 |
0.813 | -0.015 | 1 | 0.669 |
QIK |
0.812 | -0.174 | -3 | 0.801 |
CDK14 |
0.812 | 0.045 | 1 | 0.665 |
MEKK3 |
0.812 | -0.115 | 1 | 0.778 |
CDK12 |
0.812 | -0.009 | 1 | 0.630 |
DYRK1A |
0.812 | -0.003 | 1 | 0.729 |
QSK |
0.811 | -0.113 | 4 | 0.736 |
HIPK3 |
0.811 | 0.007 | 1 | 0.715 |
MEKK1 |
0.811 | -0.115 | 1 | 0.785 |
CDK16 |
0.811 | 0.060 | 1 | 0.586 |
ZAK |
0.810 | -0.101 | 1 | 0.758 |
AKT1 |
0.810 | 0.029 | -3 | 0.667 |
MEK5 |
0.810 | -0.192 | 2 | 0.793 |
NEK5 |
0.809 | -0.053 | 1 | 0.804 |
WNK4 |
0.809 | -0.106 | -2 | 0.855 |
MEKK2 |
0.809 | -0.083 | 2 | 0.768 |
IRAK4 |
0.809 | -0.071 | 1 | 0.773 |
TAO3 |
0.809 | -0.013 | 1 | 0.773 |
DCAMKL1 |
0.808 | -0.043 | -3 | 0.756 |
DYRK3 |
0.808 | 0.036 | 1 | 0.712 |
PLK4 |
0.808 | -0.133 | 2 | 0.605 |
PASK |
0.808 | -0.027 | -3 | 0.825 |
MAPKAPK5 |
0.808 | -0.149 | -3 | 0.655 |
PKACA |
0.808 | 0.023 | -2 | 0.633 |
CDK10 |
0.807 | 0.045 | 1 | 0.651 |
SIK |
0.807 | -0.127 | -3 | 0.727 |
TTBK1 |
0.807 | -0.118 | 2 | 0.611 |
LKB1 |
0.807 | 0.059 | -3 | 0.808 |
MARK3 |
0.807 | -0.109 | 4 | 0.684 |
CAMKK1 |
0.806 | -0.024 | -2 | 0.779 |
JNK1 |
0.806 | 0.047 | 1 | 0.612 |
DYRK1B |
0.806 | 0.014 | 1 | 0.654 |
PHKG2 |
0.806 | -0.056 | -3 | 0.770 |
CK2A2 |
0.806 | 0.036 | 1 | 0.677 |
BRSK1 |
0.806 | -0.132 | -3 | 0.752 |
TLK1 |
0.806 | -0.111 | -2 | 0.753 |
SMMLCK |
0.806 | -0.053 | -3 | 0.776 |
CK1D |
0.805 | 0.002 | -3 | 0.539 |
BRSK2 |
0.805 | -0.152 | -3 | 0.777 |
P70S6K |
0.805 | -0.051 | -3 | 0.658 |
GSK3B |
0.804 | -0.027 | 4 | 0.452 |
CK1G1 |
0.804 | -0.032 | -3 | 0.600 |
CAMK1G |
0.804 | -0.100 | -3 | 0.714 |
SNRK |
0.804 | -0.216 | 2 | 0.639 |
GSK3A |
0.803 | -0.000 | 4 | 0.463 |
MARK2 |
0.803 | -0.146 | 4 | 0.642 |
CAMKK2 |
0.803 | -0.014 | -2 | 0.782 |
PKCT |
0.803 | -0.054 | 2 | 0.689 |
PAK5 |
0.802 | 0.004 | -2 | 0.638 |
ERK7 |
0.802 | 0.003 | 2 | 0.499 |
DCAMKL2 |
0.802 | -0.071 | -3 | 0.779 |
GRK3 |
0.802 | -0.041 | -2 | 0.620 |
CK1A2 |
0.801 | -0.011 | -3 | 0.534 |
NEK8 |
0.801 | -0.107 | 2 | 0.777 |
TAO2 |
0.800 | -0.076 | 2 | 0.811 |
IRAK1 |
0.800 | -0.178 | -1 | 0.769 |
PKCI |
0.800 | -0.043 | 2 | 0.702 |
NEK11 |
0.800 | -0.146 | 1 | 0.767 |
PAK4 |
0.799 | 0.008 | -2 | 0.642 |
PKCE |
0.799 | 0.002 | 2 | 0.684 |
PDK1 |
0.799 | -0.067 | 1 | 0.779 |
MARK1 |
0.799 | -0.162 | 4 | 0.708 |
MAK |
0.799 | 0.079 | -2 | 0.739 |
NEK4 |
0.798 | -0.070 | 1 | 0.766 |
TNIK |
0.798 | 0.006 | 3 | 0.753 |
EEF2K |
0.798 | -0.038 | 3 | 0.707 |
CDK6 |
0.797 | 0.022 | 1 | 0.653 |
SSTK |
0.797 | -0.099 | 4 | 0.729 |
GCK |
0.797 | -0.038 | 1 | 0.770 |
DAPK3 |
0.797 | -0.010 | -3 | 0.768 |
PBK |
0.797 | 0.173 | 1 | 0.823 |
MST2 |
0.797 | -0.071 | 1 | 0.781 |
TAK1 |
0.796 | -0.030 | 1 | 0.797 |
MINK |
0.796 | -0.042 | 1 | 0.765 |
CAMK1D |
0.796 | -0.058 | -3 | 0.638 |
CK2A1 |
0.795 | 0.011 | 1 | 0.649 |
HGK |
0.795 | -0.061 | 3 | 0.744 |
PLK2 |
0.795 | -0.032 | -3 | 0.800 |
VRK1 |
0.795 | -0.014 | 2 | 0.814 |
NEK1 |
0.794 | -0.025 | 1 | 0.780 |
AKT3 |
0.794 | 0.008 | -3 | 0.578 |
MAP3K15 |
0.794 | -0.090 | 1 | 0.751 |
CDK4 |
0.793 | 0.012 | 1 | 0.617 |
PKN1 |
0.793 | -0.048 | -3 | 0.676 |
LOK |
0.793 | -0.046 | -2 | 0.770 |
ROCK2 |
0.792 | 0.050 | -3 | 0.757 |
MRCKB |
0.792 | 0.019 | -3 | 0.700 |
DAPK1 |
0.792 | -0.019 | -3 | 0.745 |
SGK1 |
0.792 | -0.004 | -3 | 0.563 |
HPK1 |
0.792 | -0.052 | 1 | 0.754 |
MRCKA |
0.792 | 0.009 | -3 | 0.722 |
PDHK3_TYR |
0.791 | 0.183 | 4 | 0.877 |
MOK |
0.791 | 0.043 | 1 | 0.719 |
MEKK6 |
0.790 | -0.117 | 1 | 0.767 |
BUB1 |
0.790 | 0.051 | -5 | 0.753 |
LRRK2 |
0.789 | -0.156 | 2 | 0.808 |
MST1 |
0.788 | -0.101 | 1 | 0.758 |
DMPK1 |
0.788 | 0.056 | -3 | 0.731 |
KHS1 |
0.788 | -0.031 | 1 | 0.751 |
BIKE |
0.788 | 0.193 | 1 | 0.814 |
CHK2 |
0.788 | -0.057 | -3 | 0.590 |
SLK |
0.787 | -0.081 | -2 | 0.706 |
SBK |
0.787 | -0.012 | -3 | 0.518 |
KHS2 |
0.786 | -0.021 | 1 | 0.759 |
YSK1 |
0.786 | -0.059 | 2 | 0.767 |
RIPK2 |
0.783 | -0.225 | 1 | 0.726 |
CAMK1A |
0.783 | -0.063 | -3 | 0.614 |
MEK2 |
0.783 | -0.184 | 2 | 0.784 |
STK33 |
0.782 | -0.166 | 2 | 0.597 |
MAP2K4_TYR |
0.782 | 0.029 | -1 | 0.874 |
PDHK4_TYR |
0.781 | 0.036 | 2 | 0.858 |
TESK1_TYR |
0.780 | -0.042 | 3 | 0.781 |
MAP2K6_TYR |
0.780 | 0.023 | -1 | 0.885 |
PKMYT1_TYR |
0.780 | -0.004 | 3 | 0.767 |
NEK3 |
0.779 | -0.093 | 1 | 0.744 |
BMPR2_TYR |
0.779 | 0.013 | -1 | 0.874 |
OSR1 |
0.778 | -0.040 | 2 | 0.764 |
TTK |
0.777 | -0.055 | -2 | 0.753 |
PDHK1_TYR |
0.777 | -0.007 | -1 | 0.909 |
PKG1 |
0.777 | -0.033 | -2 | 0.612 |
MAP2K7_TYR |
0.776 | -0.191 | 2 | 0.830 |
ROCK1 |
0.776 | 0.004 | -3 | 0.717 |
HASPIN |
0.776 | -0.036 | -1 | 0.671 |
EPHA6 |
0.776 | 0.058 | -1 | 0.873 |
LIMK2_TYR |
0.775 | 0.010 | -3 | 0.865 |
EPHB4 |
0.775 | 0.042 | -1 | 0.852 |
CRIK |
0.774 | -0.020 | -3 | 0.660 |
PINK1_TYR |
0.774 | -0.144 | 1 | 0.817 |
ASK1 |
0.774 | -0.101 | 1 | 0.744 |
MYO3B |
0.774 | -0.033 | 2 | 0.780 |
ABL2 |
0.773 | 0.075 | -1 | 0.833 |
AAK1 |
0.773 | 0.219 | 1 | 0.734 |
RET |
0.772 | -0.073 | 1 | 0.778 |
ALPHAK3 |
0.772 | -0.052 | -1 | 0.803 |
LCK |
0.771 | 0.127 | -1 | 0.848 |
TXK |
0.770 | 0.096 | 1 | 0.809 |
MST1R |
0.770 | -0.088 | 3 | 0.729 |
ABL1 |
0.770 | 0.068 | -1 | 0.823 |
FGR |
0.770 | 0.031 | 1 | 0.837 |
HCK |
0.769 | 0.058 | -1 | 0.843 |
TYK2 |
0.769 | -0.117 | 1 | 0.780 |
TAO1 |
0.769 | -0.093 | 1 | 0.709 |
YANK3 |
0.769 | -0.079 | 2 | 0.401 |
YES1 |
0.769 | 0.016 | -1 | 0.851 |
BLK |
0.769 | 0.130 | -1 | 0.859 |
JAK2 |
0.769 | -0.096 | 1 | 0.776 |
CK1A |
0.768 | -0.020 | -3 | 0.458 |
MYO3A |
0.768 | -0.085 | 1 | 0.742 |
CSF1R |
0.767 | -0.080 | 3 | 0.705 |
TYRO3 |
0.767 | -0.105 | 3 | 0.711 |
SRMS |
0.767 | 0.030 | 1 | 0.831 |
LIMK1_TYR |
0.766 | -0.152 | 2 | 0.814 |
ROS1 |
0.766 | -0.099 | 3 | 0.684 |
EPHA4 |
0.766 | 0.020 | 2 | 0.765 |
ITK |
0.766 | 0.025 | -1 | 0.822 |
FER |
0.765 | -0.052 | 1 | 0.850 |
EPHB3 |
0.765 | 0.016 | -1 | 0.839 |
EPHB1 |
0.765 | -0.019 | 1 | 0.821 |
EPHB2 |
0.764 | 0.032 | -1 | 0.839 |
JAK3 |
0.764 | -0.080 | 1 | 0.765 |
FYN |
0.763 | 0.091 | -1 | 0.823 |
DDR1 |
0.762 | -0.180 | 4 | 0.789 |
TNK2 |
0.761 | -0.068 | 3 | 0.669 |
KIT |
0.760 | -0.102 | 3 | 0.705 |
INSRR |
0.759 | -0.120 | 3 | 0.650 |
JAK1 |
0.758 | -0.057 | 1 | 0.731 |
FLT3 |
0.758 | -0.124 | 3 | 0.696 |
NEK10_TYR |
0.757 | -0.080 | 1 | 0.679 |
KDR |
0.757 | -0.111 | 3 | 0.660 |
MERTK |
0.757 | -0.066 | 3 | 0.690 |
LYN |
0.757 | 0.016 | 3 | 0.645 |
PDGFRB |
0.757 | -0.163 | 3 | 0.712 |
BMX |
0.756 | -0.021 | -1 | 0.732 |
TNNI3K_TYR |
0.756 | -0.045 | 1 | 0.774 |
FGFR2 |
0.756 | -0.163 | 3 | 0.690 |
EPHA7 |
0.755 | -0.028 | 2 | 0.760 |
TEC |
0.755 | -0.050 | -1 | 0.753 |
STLK3 |
0.755 | -0.193 | 1 | 0.724 |
BTK |
0.755 | -0.098 | -1 | 0.777 |
FLT1 |
0.754 | -0.060 | -1 | 0.872 |
TNK1 |
0.754 | -0.108 | 3 | 0.702 |
MET |
0.754 | -0.107 | 3 | 0.699 |
AXL |
0.754 | -0.131 | 3 | 0.688 |
FRK |
0.753 | -0.031 | -1 | 0.865 |
TEK |
0.753 | -0.152 | 3 | 0.644 |
FGFR1 |
0.752 | -0.179 | 3 | 0.676 |
WEE1_TYR |
0.752 | -0.081 | -1 | 0.756 |
PTK6 |
0.751 | -0.100 | -1 | 0.756 |
EPHA3 |
0.751 | -0.096 | 2 | 0.732 |
SRC |
0.750 | 0.002 | -1 | 0.821 |
PDGFRA |
0.750 | -0.196 | 3 | 0.719 |
ERBB2 |
0.749 | -0.137 | 1 | 0.741 |
EPHA5 |
0.749 | -0.023 | 2 | 0.744 |
PTK2B |
0.749 | -0.032 | -1 | 0.784 |
LTK |
0.748 | -0.134 | 3 | 0.664 |
EPHA1 |
0.748 | -0.098 | 3 | 0.674 |
NTRK1 |
0.748 | -0.170 | -1 | 0.823 |
ALK |
0.747 | -0.161 | 3 | 0.633 |
FLT4 |
0.747 | -0.146 | 3 | 0.669 |
EPHA8 |
0.746 | -0.043 | -1 | 0.836 |
FGFR3 |
0.745 | -0.169 | 3 | 0.663 |
CSK |
0.745 | -0.100 | 2 | 0.764 |
SYK |
0.744 | 0.045 | -1 | 0.807 |
EGFR |
0.744 | -0.069 | 1 | 0.658 |
NTRK2 |
0.744 | -0.209 | 3 | 0.670 |
MATK |
0.743 | -0.101 | -1 | 0.774 |
PTK2 |
0.743 | 0.010 | -1 | 0.798 |
INSR |
0.743 | -0.172 | 3 | 0.641 |
CK1G3 |
0.743 | -0.061 | -3 | 0.414 |
NTRK3 |
0.741 | -0.158 | -1 | 0.774 |
FGFR4 |
0.738 | -0.109 | -1 | 0.802 |
EPHA2 |
0.738 | -0.044 | -1 | 0.796 |
DDR2 |
0.737 | -0.148 | 3 | 0.632 |
YANK2 |
0.735 | -0.103 | 2 | 0.413 |
MUSK |
0.733 | -0.113 | 1 | 0.648 |
ERBB4 |
0.731 | -0.072 | 1 | 0.671 |
IGF1R |
0.728 | -0.173 | 3 | 0.586 |
CK1G2 |
0.726 | -0.065 | -3 | 0.512 |
FES |
0.720 | -0.132 | -1 | 0.712 |
ZAP70 |
0.716 | -0.055 | -1 | 0.714 |