Motif 732 (n=162)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00139 | KIF2A | S137 | ochoa | Kinesin-like protein KIF2A (Kinesin-2) (hK2) | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}. |
| O00151 | PDLIM1 | S153 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00186 | STXBP3 | S512 | ochoa | Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) | Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}. |
| O00192 | ARVCF | S602 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00763 | ACACB | S2117 | ochoa | Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) | Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:19900410, PubMed:20457939, PubMed:20952656, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). {ECO:0000250|UniProtKB:E9Q4Z2, ECO:0000269|PubMed:16854592, ECO:0000269|PubMed:19236960, ECO:0000269|PubMed:19900410, ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:26976583}. |
| O15042 | U2SURP | S67 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15054 | KDM6B | S971 | ochoa | Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). {ECO:0000250|UniProtKB:Q5NCY0, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914, ECO:0000269|PubMed:28262558}. |
| O43290 | SART1 | S111 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O43815 | STRN | S227 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O43852 | CALU | S277 | ochoa | Calumenin (Crocalbin) (IEF SSP 9302) | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}. |
| O60610 | DIAPH1 | S1251 | ochoa | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| O75563 | SKAP2 | S87 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| O76070 | SNCG | S72 | ochoa | Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}. |
| O94776 | MTA2 | S573 | ochoa | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| O95336 | PGLS | S46 | ochoa | 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) | Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. {ECO:0000269|PubMed:10518023}. |
| O95865 | DDAH2 | S253 | psp | Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein) | Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). {ECO:0000250|UniProtKB:Q99LD8, ECO:0000269|PubMed:21493890, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:37296100, ECO:0000305|PubMed:10493931, ECO:0000305|PubMed:21493890, ECO:0000305|PubMed:37296100}. |
| P01100 | FOS | S308 | psp | Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos) | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}. |
| P02766 | TTR | S70 | ochoa | Transthyretin (ATTR) (Prealbumin) (TBPA) | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. {ECO:0000269|PubMed:3714052}. |
| P03372 | ESR1 | S576 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
| P04075 | ALDOA | S39 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P09038 | FGF2 | S206 | psp | Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) | Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, PubMed:8663044). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879). {ECO:0000269|PubMed:1721615, ECO:0000269|PubMed:29501879, ECO:0000269|PubMed:3732516, ECO:0000269|PubMed:3964259}. |
| P09972 | ALDOC | S39 | ochoa | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | None |
| P10451 | SPP1 | S215 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P12277 | CKB | S337 | ochoa | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| P14317 | HCLS1 | S275 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P14618 | PKM | S249 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P16070 | CD44 | S697 | ochoa|psp | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P16144 | ITGB4 | S1543 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16157 | ANK1 | S781 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P20290 | BTF3 | S173 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
| P21333 | FLNA | S394 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S2279 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21980 | TGM2 | S385 | ochoa | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696, PubMed:31991788, PubMed:9252372). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:27270573, PubMed:28198360, PubMed:7935379, PubMed:9252372). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:20547769, PubMed:9623982). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}. |
| P26639 | TARS1 | S281 | ochoa | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P28749 | RBL1 | S762 | ochoa | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P30050 | RPL12 | S76 | ochoa | Large ribosomal subunit protein uL11 (60S ribosomal protein L12) | Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680). {ECO:0000269|PubMed:25901680}. |
| P35579 | MYH9 | S197 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S1719 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P40222 | TXLNA | S495 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P42330 | AKR1C3 | S32 | ochoa | Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:11165022, PubMed:14672942). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:10622721, PubMed:10998348, PubMed:11165022, PubMed:15047184, PubMed:19010934, PubMed:20036328). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10557352, PubMed:10998348, PubMed:11165022, PubMed:14672942, PubMed:7650035, PubMed:9415401). Also displays retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338). {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15047184, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:20036328, ECO:0000269|PubMed:21851338, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}. |
| P43268 | ETV4 | S73 | psp | ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) | Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:8441666}. |
| P46976 | GYG1 | S46 | ochoa | Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186) | Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase. {ECO:0000269|PubMed:22160680, ECO:0000269|PubMed:30356213}. |
| P49591 | SARS1 | S101 | psp | Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817, PubMed:9431993). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:9431993). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423847, PubMed:19423848, PubMed:24940000). {ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848, ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229, ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817, ECO:0000269|PubMed:9431993}. |
| P49790 | NUP153 | S687 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S1648 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S1765 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P52895 | AKR1C2 | S32 | ochoa | Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:15929998, PubMed:17034817, PubMed:17442338, PubMed:8573067). Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699, ECO:0000269|PubMed:8573067}. |
| P53350 | PLK1 | S387 | ochoa | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P54296 | MYOM2 | S627 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54296 | MYOM2 | S875 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P59923 | ZNF445 | S177 | ochoa | Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15) | Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). {ECO:0000269|PubMed:30602440}. |
| P62258 | YWHAE | S65 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| Q00341 | HDLBP | S1238 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q00653 | NFKB2 | S427 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q02241 | KIF23 | S924 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q04828 | AKR1C1 | S32 | ochoa | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699}. |
| Q04917 | YWHAH | S145 | ochoa | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Q05D32 | CTDSPL2 | S28 | ochoa | CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) | Probable phosphatase. {ECO:0000250}. |
| Q12846 | STX4 | S78 | psp | Syntaxin-4 (Renal carcinoma antigen NY-REN-31) | Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). Required for normal hearing (PubMed:36355422). {ECO:0000250|UniProtKB:P70452, ECO:0000250|UniProtKB:Q08850, ECO:0000269|PubMed:36355422}. |
| Q12888 | TP53BP1 | S1034 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13105 | ZBTB17 | S120 | ochoa | Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60) | Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). {ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:25245946, ECO:0000269|PubMed:9308237, ECO:0000269|PubMed:9312026}. |
| Q13129 | RLF | S642 | ochoa | Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) | May be involved in transcriptional regulation. |
| Q13207 | TBX2 | S676 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
| Q13315 | ATM | S85 | ochoa|psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13428 | TCOF1 | S369 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13492 | PICALM | S20 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q13671 | RIN1 | S719 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14135 | VGLL4 | S200 | ochoa | Transcription cofactor vestigial-like protein 4 (Vgl-4) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}. |
| Q14151 | SAFB2 | S287 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14190 | SIM2 | S115 | psp | Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15) | Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. |
| Q14315 | FLNC | S2042 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q15424 | SAFB | S288 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15785 | TOMM34 | S280 | ochoa | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
| Q16799 | RTN1 | S65 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q29980 | MICB | S345 | ochoa | MHC class I polypeptide-related sequence B (MIC-B) | Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production. {ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}. |
| Q29983 | MICA | S345 | ochoa | MHC class I polypeptide-related sequence A (MIC-A) | Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production (PubMed:10426993). {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}. |
| Q4L180 | FILIP1L | S959 | ochoa | Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) | Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}. |
| Q5JSZ5 | PRRC2B | S1667 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5QJE6 | DNTTIP2 | S170 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SRE5 | NUP188 | S1532 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
| Q5THK1 | PRR14L | S1969 | ochoa | Protein PRR14L (Proline rich 14-like protein) | None |
| Q641Q2 | WASHC2A | S504 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q658Y4 | FAM91A1 | S346 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q6NSZ9 | ZSCAN25 | S300 | ochoa | Zinc finger and SCAN domain-containing protein 25 (Zinc finger protein 498) | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6P0Q8 | MAST2 | S1717 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6PCE3 | PGM2L1 | S175 | ochoa | Glucose 1,6-bisphosphate synthase (EC 2.7.1.106) (PMMLP) (Phosphoglucomutase-2-like 1) | Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate, as acceptors (PubMed:17804405). In vitro, also exhibits very low phosphopentomutase and phosphoglucomutase activity which are most probably not physiologically relevant (PubMed:17804405). {ECO:0000269|PubMed:17804405, ECO:0000269|PubMed:18927083, ECO:0000269|PubMed:33979636}. |
| Q6ZRV2 | FAM83H | S761 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q70CQ4 | USP31 | S806 | ochoa | Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}. |
| Q7L311 | ARMCX2 | S213 | ochoa | Armadillo repeat-containing X-linked protein 2 (ARM protein lost in epithelial cancers on chromosome X 2) (Protein ALEX2) | May regulate the dynamics and distribution of mitochondria in neural cells. {ECO:0000250|UniProtKB:Q6A058}. |
| Q7L8C5 | SYT13 | S58 | ochoa | Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII) | May be involved in transport vesicle docking to the plasma membrane. {ECO:0000250}. |
| Q7Z6Z7 | HUWE1 | S3796 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86TV6 | TTC7B | S678 | ochoa | Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:26571211}. |
| Q86XP1 | DGKH | S695 | ochoa | Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q8IVT2 | MISP | S28 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8N302 | AGGF1 | S184 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N4X5 | AFAP1L2 | S305 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N5C8 | TAB3 | S669 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8N6H7 | ARFGAP2 | S433 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8NEG4 | FAM83F | S104 | ochoa | Protein FAM83F | None |
| Q8NEY1 | NAV1 | S1271 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NF91 | SYNE1 | S5919 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8TF76 | HASPIN | S211 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WUY3 | PRUNE2 | S844 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WVB6 | CHTF18 | S865 | ochoa | Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) | Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166, ECO:0000269|PubMed:20227374}. |
| Q8WWY3 | PRPF31 | S450 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:20118938, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). {ECO:0000269|PubMed:11867543, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:28781166}. |
| Q92539 | LPIN2 | S200 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q92622 | RUBCN | S410 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
| Q969S3 | ZNF622 | S143 | ochoa | Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) | Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. {ECO:0000269|PubMed:33711283}. |
| Q96BK5 | PINX1 | S226 | psp | PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1) | Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}. |
| Q96FL8 | SLC47A1 | S23 | ochoa | Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1) | Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16330770, PubMed:17509534). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:17582384, ECO:0000269|PubMed:18305230, ECO:0000269|PubMed:19158817, ECO:0000269|PubMed:21128598, ECO:0000269|PubMed:24961373, ECO:0000305|PubMed:35307651}. |
| Q96HH4 | TMEM169 | S35 | ochoa | Transmembrane protein 169 | None |
| Q96KQ7 | EHMT2 | S1084 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96RL1 | UIMC1 | S430 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96S55 | WRNIP1 | S153 | ochoa | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}. |
| Q96T58 | SPEN | S2114 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q9BQS8 | FYCO1 | S580 | ochoa | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
| Q9BR76 | CORO1B | S443 | ochoa | Coronin-1B (Coronin-2) | Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}. |
| Q9BRK4 | LZTS2 | S570 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BSJ6 | PIMREG | S91 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BTX1 | NDC1 | S394 | ochoa | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}. |
| Q9BV73 | CEP250 | S2392 | ochoa|psp | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BXB5 | OSBPL10 | S232 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BY11 | PACSIN1 | S348 | ochoa|psp | Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}. |
| Q9BZ72 | PITPNM2 | S399 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
| Q9BZV1 | UBXN6 | S96 | ochoa | UBX domain-containing protein 6 (UBX domain-containing protein 1) | May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). {ECO:0000269|PubMed:19275885, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26475856, ECO:0000269|PubMed:27753622}. |
| Q9H4A6 | GOLPH3 | S35 | ochoa | Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS) | Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}. |
| Q9H501 | ESF1 | S663 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H910 | JPT2 | S144 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9HBL0 | TNS1 | S708 | psp | Tensin-1 (EC 3.1.3.-) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}. |
| Q9HC35 | EML4 | S94 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9NQX7 | ITM2C | S22 | ochoa | Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3] | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18452648, ECO:0000269|PubMed:19366692}. |
| Q9NQX7 | ITM2C | S30 | ochoa | Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3] | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18452648, ECO:0000269|PubMed:19366692}. |
| Q9NWQ8 | PAG1 | S201 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NXG0 | CNTLN | S1333 | ochoa | Centlein (Centrosomal protein) | Required for centrosome cohesion and recruitment of CEP68 to centrosomes. {ECO:0000269|PubMed:24554434}. |
| Q9NY33 | DPP3 | S272 | ochoa | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
| Q9NYV4 | CDK12 | S420 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZM1 | MYOF | S963 | ochoa | Myoferlin (Fer-1-like protein 3) | Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}. |
| Q9P1Y5 | CAMSAP3 | S588 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P1Y5 | CAMSAP3 | S863 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9UDY2 | TJP2 | S461 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UH92 | MLX | S74 | ochoa | Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
| Q9UIF9 | BAZ2A | S509 | ochoa|psp | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UJF2 | RASAL2 | S887 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UK61 | TASOR | S68 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UNF1 | MAGED2 | S157 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UQ35 | SRRM2 | S2189 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y490 | TLN1 | S1156 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4F5 | CEP170B | S1196 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y6D9 | MAD1L1 | S598 | psp | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| Q9H814 | PHAX | Y57 | Sugiyama | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| P28066 | PSMA5 | S172 | Sugiyama | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P08631 | HCK | S98 | Sugiyama | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
| P05187 | ALPP | S192 | Sugiyama | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
| P10696 | ALPG | S189 | Sugiyama | Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}. |
| P11168 | SLC2A2 | S503 | ELM|iPTMNet|EPSD | Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2) | Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). {ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:23396969, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:3399500, ECO:0000269|PubMed:8027028, ECO:0000269|PubMed:8457197}. |
| P09923 | ALPI | S189 | Sugiyama | Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}. |
| P11586 | MTHFD1 | S765 | Sugiyama | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}. |
| P10809 | HSPD1 | S537 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P55036 | PSMD4 | S242 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}. |
| Q9NXV6 | CDKN2AIP | S175 | Sugiyama | CDKN2A-interacting protein (Collaborator of ARF) | Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}. |
| Q9H1R3 | MYLK2 | S225 | Sugiyama | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
| P22102 | GART | S105 | Sugiyama | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 5.773844e-07 | 6.239 |
| R-HSA-70171 | Glycolysis | 8.064521e-06 | 5.093 |
| R-HSA-70326 | Glucose metabolism | 2.933134e-05 | 4.533 |
| R-HSA-1640170 | Cell Cycle | 5.314389e-05 | 4.275 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.346189e-04 | 3.871 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.179162e-04 | 3.498 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 6.449091e-04 | 3.191 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 9.258362e-04 | 3.033 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.023741e-03 | 2.990 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.023741e-03 | 2.990 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.240978e-03 | 2.906 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.240978e-03 | 2.906 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.360846e-03 | 2.866 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.624416e-03 | 2.789 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.254299e-03 | 2.647 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.434699e-03 | 2.614 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.921533e-03 | 2.716 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.244270e-03 | 2.649 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.360846e-03 | 2.866 |
| R-HSA-68886 | M Phase | 1.050420e-03 | 2.979 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.058884e-03 | 2.686 |
| R-HSA-191859 | snRNP Assembly | 1.261514e-03 | 2.899 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.261514e-03 | 2.899 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.488570e-03 | 2.827 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.656461e-03 | 2.781 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.811832e-03 | 2.742 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.434699e-03 | 2.614 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.434699e-03 | 2.614 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.344715e-03 | 2.630 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.083330e-03 | 2.681 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.254299e-03 | 2.647 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.624787e-03 | 2.581 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 3.035037e-03 | 2.518 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.711206e-03 | 2.567 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.010749e-03 | 2.521 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.858140e-03 | 2.544 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.145559e-03 | 2.502 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 3.180627e-03 | 2.497 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.680410e-03 | 2.434 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.487050e-03 | 2.458 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.729331e-03 | 2.428 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.982783e-03 | 2.400 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 5.177584e-03 | 2.286 |
| R-HSA-68875 | Mitotic Prophase | 5.337638e-03 | 2.273 |
| R-HSA-3371556 | Cellular response to heat stress | 5.528339e-03 | 2.257 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.567184e-03 | 2.254 |
| R-HSA-114516 | Disinhibition of SNARE formation | 6.343217e-03 | 2.198 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 6.343217e-03 | 2.198 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.130374e-03 | 2.213 |
| R-HSA-69481 | G2/M Checkpoints | 7.005662e-03 | 2.155 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.668789e-03 | 2.176 |
| R-HSA-381070 | IRE1alpha activates chaperones | 7.151856e-03 | 2.146 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 7.179359e-03 | 2.144 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 7.179359e-03 | 2.144 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 8.421005e-03 | 2.075 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.051774e-03 | 2.094 |
| R-HSA-9700645 | ALK mutants bind TKIs | 8.995316e-03 | 2.046 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 8.995316e-03 | 2.046 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 9.277998e-03 | 2.033 |
| R-HSA-6784531 | tRNA processing in the nucleus | 9.739998e-03 | 2.011 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 1.105396e-02 | 1.956 |
| R-HSA-2262752 | Cellular responses to stress | 1.092052e-02 | 1.962 |
| R-HSA-68877 | Mitotic Prometaphase | 1.323182e-02 | 1.878 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.466769e-02 | 1.834 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.373652e-02 | 1.862 |
| R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 1.371297e-02 | 1.863 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.502217e-02 | 1.823 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.519504e-02 | 1.818 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.582736e-02 | 1.801 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.714108e-02 | 1.766 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.737673e-02 | 1.760 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.906853e-02 | 1.720 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.137797e-02 | 1.670 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.137797e-02 | 1.670 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.137797e-02 | 1.670 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.137797e-02 | 1.670 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.047887e-02 | 1.689 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.226630e-02 | 1.652 |
| R-HSA-68882 | Mitotic Anaphase | 2.227667e-02 | 1.652 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.272775e-02 | 1.643 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.557230e-02 | 1.592 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.557230e-02 | 1.592 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.369527e-02 | 1.625 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.355538e-02 | 1.628 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.572169e-02 | 1.590 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 2.572169e-02 | 1.590 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.583870e-02 | 1.588 |
| R-HSA-114608 | Platelet degranulation | 2.691609e-02 | 1.570 |
| R-HSA-2028269 | Signaling by Hippo | 2.801637e-02 | 1.553 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.039003e-02 | 1.517 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.888805e-02 | 1.539 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.039003e-02 | 1.517 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 2.907204e-02 | 1.537 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.811284e-02 | 1.551 |
| R-HSA-449836 | Other interleukin signaling | 3.284052e-02 | 1.484 |
| R-HSA-9839397 | TGFBR3 regulates FGF2 signaling | 3.460131e-02 | 1.461 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 3.536575e-02 | 1.451 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.536575e-02 | 1.451 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.789648e-02 | 1.421 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 4.586834e-02 | 1.338 |
| R-HSA-5357609 | Glycogen storage disease type II (GAA) | 4.586834e-02 | 1.338 |
| R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 4.586834e-02 | 1.338 |
| R-HSA-5619098 | Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) | 4.586834e-02 | 1.338 |
| R-HSA-9918449 | Defective visual phototransduction due to STRA6 loss of function | 4.586834e-02 | 1.338 |
| R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 4.586834e-02 | 1.338 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 4.336949e-02 | 1.363 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.512692e-02 | 1.346 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.278743e-02 | 1.369 |
| R-HSA-8953854 | Metabolism of RNA | 4.565181e-02 | 1.341 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.147053e-02 | 1.382 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 4.617348e-02 | 1.336 |
| R-HSA-3000170 | Syndecan interactions | 4.617348e-02 | 1.336 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 5.700456e-02 | 1.244 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.194341e-02 | 1.284 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.194341e-02 | 1.284 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.736316e-02 | 1.241 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.922710e-02 | 1.227 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.080884e-02 | 1.294 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.445685e-02 | 1.264 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 5.801902e-02 | 1.236 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 5.496688e-02 | 1.260 |
| R-HSA-199991 | Membrane Trafficking | 5.304533e-02 | 1.275 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.273912e-02 | 1.278 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.268478e-02 | 1.278 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.268478e-02 | 1.278 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 5.197403e-02 | 1.284 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 5.922710e-02 | 1.227 |
| R-HSA-373755 | Semaphorin interactions | 5.194341e-02 | 1.284 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.338306e-02 | 1.273 |
| R-HSA-211000 | Gene Silencing by RNA | 5.268478e-02 | 1.278 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.945135e-02 | 1.226 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 8.964339e-02 | 1.047 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 1.107758e-01 | 0.956 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.211583e-01 | 0.917 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 1.211583e-01 | 0.917 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 1.211583e-01 | 0.917 |
| R-HSA-190375 | FGFR2c ligand binding and activation | 1.809691e-01 | 0.742 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 1.905361e-01 | 0.720 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 1.999920e-01 | 0.699 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.093380e-01 | 0.679 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.093380e-01 | 0.679 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 8.436449e-02 | 1.074 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.185754e-01 | 0.660 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 2.277055e-01 | 0.643 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.277055e-01 | 0.643 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.456484e-01 | 0.610 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 2.544638e-01 | 0.594 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.544638e-01 | 0.594 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.544638e-01 | 0.594 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.544638e-01 | 0.594 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.544638e-01 | 0.594 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 2.631767e-01 | 0.580 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.099602e-02 | 1.149 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 2.717883e-01 | 0.566 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 2.717883e-01 | 0.566 |
| R-HSA-380287 | Centrosome maturation | 7.513568e-02 | 1.124 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 2.802997e-01 | 0.552 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 2.970269e-01 | 0.527 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 3.052449e-01 | 0.515 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.052449e-01 | 0.515 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.069121e-01 | 0.971 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.116340e-01 | 0.674 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.416995e-01 | 0.617 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.118220e-01 | 0.951 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 8.817353e-02 | 1.055 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 2.456484e-01 | 0.610 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 2.544638e-01 | 0.594 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.802997e-01 | 0.552 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 3.052449e-01 | 0.515 |
| R-HSA-9664873 | Pexophagy | 1.415629e-01 | 0.849 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.052449e-01 | 0.515 |
| R-HSA-190241 | FGFR2 ligand binding and activation | 2.631767e-01 | 0.580 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.290081e-01 | 0.889 |
| R-HSA-8939211 | ESR-mediated signaling | 8.395053e-02 | 1.076 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.587832e-02 | 1.120 |
| R-HSA-72172 | mRNA Splicing | 2.697644e-01 | 0.569 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.853515e-01 | 0.732 |
| R-HSA-190377 | FGFR2b ligand binding and activation | 1.515878e-01 | 0.819 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 1.809691e-01 | 0.742 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.097847e-01 | 0.959 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.611797e-01 | 0.793 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 9.502596e-02 | 1.022 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.484243e-01 | 0.828 |
| R-HSA-2033519 | Activated point mutants of FGFR2 | 2.367294e-01 | 0.626 |
| R-HSA-9907900 | Proteasome assembly | 1.251020e-01 | 0.903 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.489401e-01 | 0.827 |
| R-HSA-6798695 | Neutrophil degranulation | 1.120144e-01 | 0.951 |
| R-HSA-5693538 | Homology Directed Repair | 2.031447e-01 | 0.692 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 2.367294e-01 | 0.626 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.717883e-01 | 0.566 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.979666e-01 | 0.526 |
| R-HSA-176417 | Phosphorylation of Emi1 | 8.964339e-02 | 1.047 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 1.002713e-01 | 0.999 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.415629e-01 | 0.849 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 1.515878e-01 | 0.819 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 1.614962e-01 | 0.792 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.809691e-01 | 0.742 |
| R-HSA-190322 | FGFR4 ligand binding and activation | 1.809691e-01 | 0.742 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 1.905361e-01 | 0.720 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.999920e-01 | 0.699 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.999920e-01 | 0.699 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.999920e-01 | 0.699 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.093380e-01 | 0.679 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 8.436449e-02 | 1.074 |
| R-HSA-3229121 | Glycogen storage diseases | 2.277055e-01 | 0.643 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.367294e-01 | 0.626 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.060386e-01 | 0.975 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 2.456484e-01 | 0.610 |
| R-HSA-3322077 | Glycogen synthesis | 2.544638e-01 | 0.594 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.970269e-01 | 0.527 |
| R-HSA-1538133 | G0 and Early G1 | 7.410813e-02 | 1.130 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.850084e-01 | 0.545 |
| R-HSA-447043 | Neurofascin interactions | 1.002713e-01 | 0.999 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.456484e-01 | 0.610 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.660079e-01 | 0.780 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.314202e-01 | 0.881 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.314202e-01 | 0.881 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 1.415629e-01 | 0.849 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.905361e-01 | 0.720 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 8.436449e-02 | 1.074 |
| R-HSA-69541 | Stabilization of p53 | 1.023284e-01 | 0.990 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.468277e-02 | 1.189 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 2.417418e-01 | 0.617 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.322855e-01 | 0.878 |
| R-HSA-205025 | NADE modulates death signalling | 6.801148e-02 | 1.167 |
| R-HSA-8981373 | Intestinal hexose absorption | 8.964339e-02 | 1.047 |
| R-HSA-1483226 | Synthesis of PI | 1.515878e-01 | 0.819 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.614962e-01 | 0.792 |
| R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 1.809691e-01 | 0.742 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 1.999920e-01 | 0.699 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.631767e-01 | 0.580 |
| R-HSA-69275 | G2/M Transition | 9.534255e-02 | 1.021 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 9.830765e-02 | 1.007 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.052449e-01 | 0.515 |
| R-HSA-1500620 | Meiosis | 2.979666e-01 | 0.526 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.988460e-01 | 0.701 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.369042e-01 | 0.864 |
| R-HSA-983189 | Kinesins | 1.903751e-01 | 0.720 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.374243e-01 | 0.624 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.449041e-01 | 0.839 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.449041e-01 | 0.839 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.322855e-01 | 0.878 |
| R-HSA-2559583 | Cellular Senescence | 8.672897e-02 | 1.062 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 6.801148e-02 | 1.167 |
| R-HSA-447038 | NrCAM interactions | 7.889060e-02 | 1.103 |
| R-HSA-444821 | Relaxin receptors | 8.964339e-02 | 1.047 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.002713e-01 | 0.999 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.611797e-01 | 0.793 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.374243e-01 | 0.624 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.374243e-01 | 0.624 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.522670e-01 | 0.598 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.030986e-01 | 0.692 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 7.889060e-02 | 1.103 |
| R-HSA-8964011 | HDL clearance | 1.002713e-01 | 0.999 |
| R-HSA-164944 | Nef and signal transduction | 1.002713e-01 | 0.999 |
| R-HSA-447041 | CHL1 interactions | 1.107758e-01 | 0.956 |
| R-HSA-448706 | Interleukin-1 processing | 1.314202e-01 | 0.881 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.515878e-01 | 0.819 |
| R-HSA-2033514 | FGFR3 mutant receptor activation | 1.809691e-01 | 0.742 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.905361e-01 | 0.720 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.717883e-01 | 0.566 |
| R-HSA-200425 | Carnitine shuttle | 2.887122e-01 | 0.540 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.735947e-01 | 0.760 |
| R-HSA-163685 | Integration of energy metabolism | 1.071030e-01 | 0.970 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.680048e-01 | 0.775 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.185754e-01 | 0.660 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.367294e-01 | 0.626 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.893310e-01 | 0.539 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.484243e-01 | 0.828 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.946046e-01 | 0.711 |
| R-HSA-8963676 | Intestinal absorption | 1.211583e-01 | 0.917 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.173794e-01 | 0.930 |
| R-HSA-71288 | Creatine metabolism | 2.544638e-01 | 0.594 |
| R-HSA-2160916 | Hyaluronan degradation | 3.052449e-01 | 0.515 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.159151e-01 | 0.666 |
| R-HSA-9609690 | HCMV Early Events | 2.467528e-01 | 0.608 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.781342e-01 | 0.749 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.028881e-01 | 0.519 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.737332e-01 | 0.760 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.375942e-01 | 0.861 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.375942e-01 | 0.861 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.375942e-01 | 0.861 |
| R-HSA-196780 | Biotin transport and metabolism | 1.999920e-01 | 0.699 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.737332e-01 | 0.760 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.456910e-01 | 0.837 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.595206e-01 | 0.797 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.708620e-01 | 0.767 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.061488e-01 | 0.686 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.988460e-01 | 0.701 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.022787e-01 | 0.520 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.061488e-01 | 0.686 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.152213e-01 | 0.667 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.152213e-01 | 0.667 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.097847e-01 | 0.959 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.824275e-01 | 0.739 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.912364e-01 | 0.718 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.093380e-01 | 0.679 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.052449e-01 | 0.515 |
| R-HSA-450294 | MAP kinase activation | 1.946046e-01 | 0.711 |
| R-HSA-168255 | Influenza Infection | 8.533493e-02 | 1.069 |
| R-HSA-3214842 | HDMs demethylate histones | 3.052449e-01 | 0.515 |
| R-HSA-448424 | Interleukin-17 signaling | 2.331111e-01 | 0.632 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.314202e-01 | 0.881 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.515878e-01 | 0.819 |
| R-HSA-189200 | Cellular hexose transport | 2.802997e-01 | 0.552 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.073615e-01 | 0.683 |
| R-HSA-114452 | Activation of BH3-only proteins | 6.751361e-02 | 1.171 |
| R-HSA-9610379 | HCMV Late Events | 1.517817e-01 | 0.819 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.569282e-01 | 0.590 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.211583e-01 | 0.917 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.590410e-01 | 0.587 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 1.173794e-01 | 0.930 |
| R-HSA-180292 | GAB1 signalosome | 2.367294e-01 | 0.626 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.456484e-01 | 0.610 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.513568e-02 | 1.124 |
| R-HSA-216083 | Integrin cell surface interactions | 2.676991e-01 | 0.572 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 6.429411e-02 | 1.192 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.717883e-01 | 0.566 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.763564e-01 | 0.559 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.210588e-02 | 1.207 |
| R-HSA-2453864 | Retinoid cycle disease events | 3.052449e-01 | 0.515 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.979666e-01 | 0.526 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 1.402756e-01 | 0.853 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.462801e-01 | 0.835 |
| R-HSA-975634 | Retinoid metabolism and transport | 6.696328e-02 | 1.174 |
| R-HSA-2474795 | Diseases associated with visual transduction | 3.052449e-01 | 0.515 |
| R-HSA-9675143 | Diseases of the neuronal system | 3.052449e-01 | 0.515 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.676991e-01 | 0.572 |
| R-HSA-74160 | Gene expression (Transcription) | 1.785181e-01 | 0.748 |
| R-HSA-8983711 | OAS antiviral response | 1.712895e-01 | 0.766 |
| R-HSA-3000157 | Laminin interactions | 3.052449e-01 | 0.515 |
| R-HSA-8963743 | Digestion and absorption | 2.030986e-01 | 0.692 |
| R-HSA-1500931 | Cell-Cell communication | 2.043899e-01 | 0.690 |
| R-HSA-446728 | Cell junction organization | 2.732077e-01 | 0.564 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 8.817353e-02 | 1.055 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 1.737332e-01 | 0.760 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 2.093380e-01 | 0.679 |
| R-HSA-70263 | Gluconeogenesis | 1.408917e-01 | 0.851 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 8.436449e-02 | 1.074 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 9.865549e-02 | 1.006 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.456484e-01 | 0.610 |
| R-HSA-9830364 | Formation of the nephric duct | 3.052449e-01 | 0.515 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.887122e-01 | 0.540 |
| R-HSA-162906 | HIV Infection | 7.255454e-02 | 1.139 |
| R-HSA-379724 | tRNA Aminoacylation | 1.903751e-01 | 0.720 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.030986e-01 | 0.692 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.970269e-01 | 0.527 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.970269e-01 | 0.527 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.955443e-02 | 1.099 |
| R-HSA-449147 | Signaling by Interleukins | 2.296378e-01 | 0.639 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.570790e-01 | 0.804 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.349307e-01 | 0.870 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.366709e-01 | 0.626 |
| R-HSA-186712 | Regulation of beta-cell development | 1.861585e-01 | 0.730 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.720282e-01 | 0.565 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.628411e-02 | 1.016 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.358341e-01 | 0.867 |
| R-HSA-913531 | Interferon Signaling | 1.988876e-01 | 0.701 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.735947e-01 | 0.760 |
| R-HSA-5619102 | SLC transporter disorders | 6.831546e-02 | 1.165 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 2.646154e-01 | 0.577 |
| R-HSA-109581 | Apoptosis | 1.628019e-01 | 0.788 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.374243e-01 | 0.624 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.205962e-01 | 0.919 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.455707e-01 | 0.837 |
| R-HSA-5357801 | Programmed Cell Death | 2.723457e-01 | 0.565 |
| R-HSA-72306 | tRNA processing | 1.833357e-01 | 0.737 |
| R-HSA-162587 | HIV Life Cycle | 1.517817e-01 | 0.819 |
| R-HSA-2187338 | Visual phototransduction | 3.060768e-01 | 0.514 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.092668e-01 | 0.510 |
| R-HSA-70268 | Pyruvate metabolism | 3.108890e-01 | 0.507 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.133674e-01 | 0.504 |
| R-HSA-9845614 | Sphingolipid catabolism | 3.133674e-01 | 0.504 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.194774e-01 | 0.496 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 3.213953e-01 | 0.493 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.213953e-01 | 0.493 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 3.213953e-01 | 0.493 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 3.213953e-01 | 0.493 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.213953e-01 | 0.493 |
| R-HSA-75109 | Triglyceride biosynthesis | 3.213953e-01 | 0.493 |
| R-HSA-1483213 | Synthesis of PE | 3.213953e-01 | 0.493 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.213953e-01 | 0.493 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.213953e-01 | 0.493 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.220368e-01 | 0.492 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.252306e-01 | 0.488 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 3.293299e-01 | 0.482 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.293299e-01 | 0.482 |
| R-HSA-9757110 | Prednisone ADME | 3.293299e-01 | 0.482 |
| R-HSA-622312 | Inflammasomes | 3.293299e-01 | 0.482 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.365748e-01 | 0.473 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.371722e-01 | 0.472 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 3.371722e-01 | 0.472 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 3.371722e-01 | 0.472 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.371722e-01 | 0.472 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.371722e-01 | 0.472 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.449233e-01 | 0.462 |
| R-HSA-109582 | Hemostasis | 3.464949e-01 | 0.460 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.475768e-01 | 0.459 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.485141e-01 | 0.458 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.525842e-01 | 0.453 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.535441e-01 | 0.452 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.577636e-01 | 0.446 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 3.601560e-01 | 0.444 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.601560e-01 | 0.444 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.601560e-01 | 0.444 |
| R-HSA-9679506 | SARS-CoV Infections | 3.649763e-01 | 0.438 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 3.661724e-01 | 0.436 |
| R-HSA-354192 | Integrin signaling | 3.676397e-01 | 0.435 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.676397e-01 | 0.435 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.676397e-01 | 0.435 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.676397e-01 | 0.435 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.676397e-01 | 0.435 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.676397e-01 | 0.435 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.676397e-01 | 0.435 |
| R-HSA-1266738 | Developmental Biology | 3.682868e-01 | 0.434 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.750364e-01 | 0.426 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.750364e-01 | 0.426 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.750364e-01 | 0.426 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.762448e-01 | 0.425 |
| R-HSA-8957322 | Metabolism of steroids | 3.785626e-01 | 0.422 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.787058e-01 | 0.422 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.823469e-01 | 0.418 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.823469e-01 | 0.418 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.823469e-01 | 0.418 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.823469e-01 | 0.418 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.823469e-01 | 0.418 |
| R-HSA-2142845 | Hyaluronan metabolism | 3.823469e-01 | 0.418 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.823469e-01 | 0.418 |
| R-HSA-5365859 | RA biosynthesis pathway | 3.823469e-01 | 0.418 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 3.856874e-01 | 0.414 |
| R-HSA-212436 | Generic Transcription Pathway | 3.878674e-01 | 0.411 |
| R-HSA-4839726 | Chromatin organization | 3.882406e-01 | 0.411 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.888438e-01 | 0.410 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.895724e-01 | 0.409 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.895724e-01 | 0.409 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.895724e-01 | 0.409 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.895724e-01 | 0.409 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.895724e-01 | 0.409 |
| R-HSA-169911 | Regulation of Apoptosis | 3.895724e-01 | 0.409 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.895724e-01 | 0.409 |
| R-HSA-9609646 | HCMV Infection | 3.908821e-01 | 0.408 |
| R-HSA-1474244 | Extracellular matrix organization | 3.947792e-01 | 0.404 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 3.952545e-01 | 0.403 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 3.967138e-01 | 0.402 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.967138e-01 | 0.402 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.967138e-01 | 0.402 |
| R-HSA-3371511 | HSF1 activation | 3.967138e-01 | 0.402 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.967138e-01 | 0.402 |
| R-HSA-69205 | G1/S-Specific Transcription | 3.967138e-01 | 0.402 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.034540e-01 | 0.394 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.037721e-01 | 0.394 |
| R-HSA-4641258 | Degradation of DVL | 4.037721e-01 | 0.394 |
| R-HSA-4641257 | Degradation of AXIN | 4.037721e-01 | 0.394 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4.037721e-01 | 0.394 |
| R-HSA-196757 | Metabolism of folate and pterines | 4.037721e-01 | 0.394 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.037721e-01 | 0.394 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 4.037721e-01 | 0.394 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.037721e-01 | 0.394 |
| R-HSA-5688426 | Deubiquitination | 4.040646e-01 | 0.394 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.107483e-01 | 0.386 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.116009e-01 | 0.386 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 4.176432e-01 | 0.379 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.176432e-01 | 0.379 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.176432e-01 | 0.379 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.176432e-01 | 0.379 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.176432e-01 | 0.379 |
| R-HSA-71336 | Pentose phosphate pathway | 4.176432e-01 | 0.379 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.176432e-01 | 0.379 |
| R-HSA-202403 | TCR signaling | 4.196931e-01 | 0.377 |
| R-HSA-8982491 | Glycogen metabolism | 4.244579e-01 | 0.372 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.244579e-01 | 0.372 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.244579e-01 | 0.372 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.244579e-01 | 0.372 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.244579e-01 | 0.372 |
| R-HSA-5260271 | Diseases of Immune System | 4.244579e-01 | 0.372 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.244579e-01 | 0.372 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.244579e-01 | 0.372 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.311933e-01 | 0.365 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.311933e-01 | 0.365 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.311933e-01 | 0.365 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.311933e-01 | 0.365 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.311933e-01 | 0.365 |
| R-HSA-9607240 | FLT3 Signaling | 4.311933e-01 | 0.365 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.316836e-01 | 0.365 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.357063e-01 | 0.361 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.378503e-01 | 0.359 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.378503e-01 | 0.359 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.378503e-01 | 0.359 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.378503e-01 | 0.359 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.378503e-01 | 0.359 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.378503e-01 | 0.359 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.378503e-01 | 0.359 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.378503e-01 | 0.359 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.378503e-01 | 0.359 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 4.396727e-01 | 0.357 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.436239e-01 | 0.353 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.444297e-01 | 0.352 |
| R-HSA-5617833 | Cilium Assembly | 4.448458e-01 | 0.352 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.479025e-01 | 0.349 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.509326e-01 | 0.346 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.509326e-01 | 0.346 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.529224e-01 | 0.344 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.553846e-01 | 0.342 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.573597e-01 | 0.340 |
| R-HSA-69236 | G1 Phase | 4.573597e-01 | 0.340 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.573597e-01 | 0.340 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.631460e-01 | 0.334 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.637120e-01 | 0.334 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.637120e-01 | 0.334 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.637120e-01 | 0.334 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.637120e-01 | 0.334 |
| R-HSA-2453902 | The canonical retinoid cycle in rods (twilight vision) | 4.637120e-01 | 0.334 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.637120e-01 | 0.334 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.637120e-01 | 0.334 |
| R-HSA-9824272 | Somitogenesis | 4.637120e-01 | 0.334 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.699903e-01 | 0.328 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.699903e-01 | 0.328 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.699903e-01 | 0.328 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.699903e-01 | 0.328 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.699903e-01 | 0.328 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.699903e-01 | 0.328 |
| R-HSA-9675135 | Diseases of DNA repair | 4.699903e-01 | 0.328 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.699903e-01 | 0.328 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.699903e-01 | 0.328 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.699903e-01 | 0.328 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.699903e-01 | 0.328 |
| R-HSA-75153 | Apoptotic execution phase | 4.699903e-01 | 0.328 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 4.703805e-01 | 0.328 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.750986e-01 | 0.323 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.761955e-01 | 0.322 |
| R-HSA-1483191 | Synthesis of PC | 4.761955e-01 | 0.322 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.784734e-01 | 0.320 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.823285e-01 | 0.317 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.840294e-01 | 0.315 |
| R-HSA-1280218 | Adaptive Immune System | 4.856841e-01 | 0.314 |
| R-HSA-9766229 | Degradation of CDH1 | 4.883900e-01 | 0.311 |
| R-HSA-69206 | G1/S Transition | 4.897934e-01 | 0.310 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.917312e-01 | 0.308 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.943809e-01 | 0.306 |
| R-HSA-109704 | PI3K Cascade | 4.943809e-01 | 0.306 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 4.943809e-01 | 0.306 |
| R-HSA-912446 | Meiotic recombination | 5.003020e-01 | 0.301 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.003020e-01 | 0.301 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.003020e-01 | 0.301 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 5.003020e-01 | 0.301 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.061541e-01 | 0.296 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.061541e-01 | 0.296 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.061541e-01 | 0.296 |
| R-HSA-1483257 | Phospholipid metabolism | 5.066873e-01 | 0.295 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.091614e-01 | 0.293 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.119381e-01 | 0.291 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.119381e-01 | 0.291 |
| R-HSA-1221632 | Meiotic synapsis | 5.119381e-01 | 0.291 |
| R-HSA-8956320 | Nucleotide biosynthesis | 5.119381e-01 | 0.291 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.119381e-01 | 0.291 |
| R-HSA-1474165 | Reproduction | 5.119680e-01 | 0.291 |
| R-HSA-168256 | Immune System | 5.131827e-01 | 0.290 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.176547e-01 | 0.286 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 5.192186e-01 | 0.285 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.233046e-01 | 0.281 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.233046e-01 | 0.281 |
| R-HSA-5654736 | Signaling by FGFR1 | 5.288888e-01 | 0.277 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.288888e-01 | 0.277 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.288888e-01 | 0.277 |
| R-HSA-8935690 | Digestion | 5.288888e-01 | 0.277 |
| R-HSA-177929 | Signaling by EGFR | 5.288888e-01 | 0.277 |
| R-HSA-75893 | TNF signaling | 5.288888e-01 | 0.277 |
| R-HSA-112399 | IRS-mediated signalling | 5.344078e-01 | 0.272 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.344078e-01 | 0.272 |
| R-HSA-1483166 | Synthesis of PA | 5.344078e-01 | 0.272 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.344078e-01 | 0.272 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.370305e-01 | 0.270 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.440280e-01 | 0.264 |
| R-HSA-180786 | Extension of Telomeres | 5.452537e-01 | 0.263 |
| R-HSA-8979227 | Triglyceride metabolism | 5.452537e-01 | 0.263 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.452537e-01 | 0.263 |
| R-HSA-6807070 | PTEN Regulation | 5.474992e-01 | 0.262 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.505821e-01 | 0.259 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.505821e-01 | 0.259 |
| R-HSA-351202 | Metabolism of polyamines | 5.505821e-01 | 0.259 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.505821e-01 | 0.259 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 5.505821e-01 | 0.259 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.505821e-01 | 0.259 |
| R-HSA-9664407 | Parasite infection | 5.509520e-01 | 0.259 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.509520e-01 | 0.259 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.509520e-01 | 0.259 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.558483e-01 | 0.255 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.558483e-01 | 0.255 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.610532e-01 | 0.251 |
| R-HSA-1268020 | Mitochondrial protein import | 5.610532e-01 | 0.251 |
| R-HSA-186797 | Signaling by PDGF | 5.610532e-01 | 0.251 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.645785e-01 | 0.248 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.679387e-01 | 0.246 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.712815e-01 | 0.243 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.712815e-01 | 0.243 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.763064e-01 | 0.239 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.763064e-01 | 0.239 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.779074e-01 | 0.238 |
| R-HSA-9758941 | Gastrulation | 5.844599e-01 | 0.233 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.861812e-01 | 0.232 |
| R-HSA-9830369 | Kidney development | 5.861812e-01 | 0.232 |
| R-HSA-162582 | Signal Transduction | 5.872064e-01 | 0.231 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.909374e-01 | 0.228 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.910324e-01 | 0.228 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.941481e-01 | 0.226 |
| R-HSA-73887 | Death Receptor Signaling | 6.005133e-01 | 0.221 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.005657e-01 | 0.221 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.005657e-01 | 0.221 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.005657e-01 | 0.221 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.005657e-01 | 0.221 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.005657e-01 | 0.221 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.005657e-01 | 0.221 |
| R-HSA-597592 | Post-translational protein modification | 6.027696e-01 | 0.220 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.052491e-01 | 0.218 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.052491e-01 | 0.218 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.098779e-01 | 0.215 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.098779e-01 | 0.215 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.098779e-01 | 0.215 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.144527e-01 | 0.212 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 6.144527e-01 | 0.212 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.144527e-01 | 0.212 |
| R-HSA-877300 | Interferon gamma signaling | 6.160982e-01 | 0.210 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.189742e-01 | 0.208 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.189742e-01 | 0.208 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.189742e-01 | 0.208 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.191590e-01 | 0.208 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.234429e-01 | 0.205 |
| R-HSA-5689603 | UCH proteinases | 6.278594e-01 | 0.202 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.304610e-01 | 0.200 |
| R-HSA-2408522 | Selenoamino acid metabolism | 6.312156e-01 | 0.200 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.365386e-01 | 0.196 |
| R-HSA-5619084 | ABC transporter disorders | 6.365386e-01 | 0.196 |
| R-HSA-4086400 | PCP/CE pathway | 6.365386e-01 | 0.196 |
| R-HSA-9659379 | Sensory processing of sound | 6.408023e-01 | 0.193 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.450163e-01 | 0.190 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.450163e-01 | 0.190 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.450163e-01 | 0.190 |
| R-HSA-977225 | Amyloid fiber formation | 6.491812e-01 | 0.188 |
| R-HSA-422475 | Axon guidance | 6.555523e-01 | 0.183 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.600588e-01 | 0.180 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.600588e-01 | 0.180 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.600588e-01 | 0.180 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.600588e-01 | 0.180 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.600588e-01 | 0.180 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.613862e-01 | 0.180 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.628420e-01 | 0.179 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.656070e-01 | 0.177 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 6.656070e-01 | 0.177 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.692873e-01 | 0.174 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.731689e-01 | 0.172 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.731689e-01 | 0.172 |
| R-HSA-156902 | Peptide chain elongation | 6.807965e-01 | 0.167 |
| R-HSA-9663891 | Selective autophagy | 6.807965e-01 | 0.167 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.807965e-01 | 0.167 |
| R-HSA-9658195 | Leishmania infection | 6.878170e-01 | 0.163 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.878170e-01 | 0.163 |
| R-HSA-202424 | Downstream TCR signaling | 6.882470e-01 | 0.162 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.899673e-01 | 0.161 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.919071e-01 | 0.160 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.955244e-01 | 0.158 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.990996e-01 | 0.155 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.990996e-01 | 0.155 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.990996e-01 | 0.155 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.002635e-01 | 0.155 |
| R-HSA-2029481 | FCGR activation | 7.026329e-01 | 0.153 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.026329e-01 | 0.153 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.061250e-01 | 0.151 |
| R-HSA-1474290 | Collagen formation | 7.061250e-01 | 0.151 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.095763e-01 | 0.149 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.095763e-01 | 0.149 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.129873e-01 | 0.147 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.129873e-01 | 0.147 |
| R-HSA-9675108 | Nervous system development | 7.140183e-01 | 0.146 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.195491e-01 | 0.143 |
| R-HSA-157579 | Telomere Maintenance | 7.196902e-01 | 0.143 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.196902e-01 | 0.143 |
| R-HSA-190236 | Signaling by FGFR | 7.229830e-01 | 0.141 |
| R-HSA-422356 | Regulation of insulin secretion | 7.229830e-01 | 0.141 |
| R-HSA-168249 | Innate Immune System | 7.231625e-01 | 0.141 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.262373e-01 | 0.139 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.294536e-01 | 0.137 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.294536e-01 | 0.137 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.335602e-01 | 0.135 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.358370e-01 | 0.133 |
| R-HSA-192823 | Viral mRNA Translation | 7.388787e-01 | 0.131 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.419472e-01 | 0.130 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.419472e-01 | 0.130 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.419472e-01 | 0.130 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.538668e-01 | 0.123 |
| R-HSA-69239 | Synthesis of DNA | 7.538668e-01 | 0.123 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.567601e-01 | 0.121 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.567601e-01 | 0.121 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.575340e-01 | 0.121 |
| R-HSA-397014 | Muscle contraction | 7.577100e-01 | 0.120 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.596196e-01 | 0.119 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.636316e-01 | 0.117 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.679990e-01 | 0.115 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.679990e-01 | 0.115 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.679990e-01 | 0.115 |
| R-HSA-418990 | Adherens junctions interactions | 7.700732e-01 | 0.113 |
| R-HSA-8951664 | Neddylation | 7.760474e-01 | 0.110 |
| R-HSA-72766 | Translation | 7.763336e-01 | 0.110 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.838959e-01 | 0.106 |
| R-HSA-373760 | L1CAM interactions | 7.838959e-01 | 0.106 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.838959e-01 | 0.106 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.857048e-01 | 0.105 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 7.913229e-01 | 0.102 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.931667e-01 | 0.101 |
| R-HSA-73886 | Chromosome Maintenance | 7.963121e-01 | 0.099 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.963121e-01 | 0.099 |
| R-HSA-9824446 | Viral Infection Pathways | 7.965918e-01 | 0.099 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.010776e-01 | 0.096 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.102783e-01 | 0.091 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.147186e-01 | 0.089 |
| R-HSA-9843745 | Adipogenesis | 8.232915e-01 | 0.084 |
| R-HSA-73894 | DNA Repair | 8.252414e-01 | 0.083 |
| R-HSA-9909396 | Circadian clock | 8.253724e-01 | 0.083 |
| R-HSA-421270 | Cell-cell junction organization | 8.287036e-01 | 0.082 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.354166e-01 | 0.078 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.392714e-01 | 0.076 |
| R-HSA-1632852 | Macroautophagy | 8.448860e-01 | 0.073 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.448860e-01 | 0.073 |
| R-HSA-392499 | Metabolism of proteins | 8.466450e-01 | 0.072 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.533599e-01 | 0.069 |
| R-HSA-69242 | S Phase | 8.589223e-01 | 0.066 |
| R-HSA-166520 | Signaling by NTRKs | 8.589223e-01 | 0.066 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.622293e-01 | 0.064 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.654591e-01 | 0.063 |
| R-HSA-2142753 | Arachidonate metabolism | 8.654591e-01 | 0.063 |
| R-HSA-9609507 | Protein localization | 8.670457e-01 | 0.062 |
| R-HSA-69306 | DNA Replication | 8.670457e-01 | 0.062 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.686137e-01 | 0.061 |
| R-HSA-9612973 | Autophagy | 8.716946e-01 | 0.060 |
| R-HSA-9711097 | Cellular response to starvation | 8.747037e-01 | 0.058 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.747037e-01 | 0.058 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.926223e-01 | 0.049 |
| R-HSA-418555 | G alpha (s) signalling events | 8.938901e-01 | 0.049 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.079900e-01 | 0.042 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.112134e-01 | 0.040 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.132997e-01 | 0.039 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.183045e-01 | 0.037 |
| R-HSA-428157 | Sphingolipid metabolism | 9.257211e-01 | 0.034 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.265472e-01 | 0.033 |
| R-HSA-9748784 | Drug ADME | 9.400498e-01 | 0.027 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.443238e-01 | 0.025 |
| R-HSA-72312 | rRNA processing | 9.492629e-01 | 0.023 |
| R-HSA-15869 | Metabolism of nucleotides | 9.516262e-01 | 0.022 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.521997e-01 | 0.021 |
| R-HSA-157118 | Signaling by NOTCH | 9.538800e-01 | 0.021 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.581209e-01 | 0.019 |
| R-HSA-1643685 | Disease | 9.608450e-01 | 0.017 |
| R-HSA-8978868 | Fatty acid metabolism | 9.621153e-01 | 0.017 |
| R-HSA-416476 | G alpha (q) signalling events | 9.653700e-01 | 0.015 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.674316e-01 | 0.014 |
| R-HSA-5663205 | Infectious disease | 9.698046e-01 | 0.013 |
| R-HSA-195721 | Signaling by WNT | 9.769409e-01 | 0.010 |
| R-HSA-556833 | Metabolism of lipids | 9.858069e-01 | 0.006 |
| R-HSA-1430728 | Metabolism | 9.925347e-01 | 0.003 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.928074e-01 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 9.951689e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.977867e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.992445e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.993236e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.997025e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.998277e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.858 | 0.186 | 2 | 0.892 |
CLK3 |
0.846 | 0.179 | 1 | 0.848 |
CDC7 |
0.844 | 0.097 | 1 | 0.830 |
MOS |
0.844 | 0.159 | 1 | 0.860 |
PIM3 |
0.840 | 0.087 | -3 | 0.787 |
PRPK |
0.837 | -0.007 | -1 | 0.855 |
ERK5 |
0.837 | 0.146 | 1 | 0.840 |
MTOR |
0.836 | 0.006 | 1 | 0.770 |
NDR2 |
0.835 | 0.058 | -3 | 0.791 |
CDKL5 |
0.834 | 0.128 | -3 | 0.760 |
NLK |
0.834 | 0.082 | 1 | 0.823 |
CDKL1 |
0.833 | 0.082 | -3 | 0.762 |
SKMLCK |
0.833 | 0.115 | -2 | 0.814 |
SRPK1 |
0.832 | 0.120 | -3 | 0.719 |
MARK4 |
0.832 | 0.111 | 4 | 0.854 |
RSK2 |
0.832 | 0.094 | -3 | 0.739 |
IKKB |
0.831 | -0.050 | -2 | 0.692 |
GRK1 |
0.831 | 0.101 | -2 | 0.768 |
HIPK4 |
0.830 | 0.111 | 1 | 0.790 |
DSTYK |
0.830 | -0.002 | 2 | 0.886 |
PRKD1 |
0.830 | 0.115 | -3 | 0.793 |
RAF1 |
0.830 | -0.056 | 1 | 0.805 |
CAMK1B |
0.830 | 0.014 | -3 | 0.802 |
KIS |
0.828 | 0.077 | 1 | 0.715 |
TBK1 |
0.828 | -0.035 | 1 | 0.705 |
BMPR2 |
0.827 | -0.112 | -2 | 0.829 |
ULK2 |
0.826 | -0.080 | 2 | 0.787 |
IKKE |
0.826 | -0.026 | 1 | 0.708 |
ATR |
0.826 | -0.019 | 1 | 0.782 |
HUNK |
0.825 | 0.014 | 2 | 0.831 |
TSSK2 |
0.825 | 0.124 | -5 | 0.759 |
NUAK2 |
0.825 | 0.026 | -3 | 0.780 |
PDHK4 |
0.825 | -0.220 | 1 | 0.822 |
WNK1 |
0.825 | 0.017 | -2 | 0.831 |
MST4 |
0.825 | 0.046 | 2 | 0.832 |
NDR1 |
0.824 | 0.007 | -3 | 0.778 |
NEK6 |
0.824 | -0.014 | -2 | 0.811 |
PKN3 |
0.824 | 0.009 | -3 | 0.774 |
CAMK2G |
0.824 | -0.088 | 2 | 0.757 |
CHAK2 |
0.824 | 0.015 | -1 | 0.812 |
GRK5 |
0.824 | -0.070 | -3 | 0.782 |
IKKA |
0.823 | 0.012 | -2 | 0.693 |
GCN2 |
0.823 | -0.184 | 2 | 0.778 |
BMPR1B |
0.823 | 0.123 | 1 | 0.775 |
AMPKA1 |
0.823 | 0.059 | -3 | 0.797 |
PRKD2 |
0.823 | 0.079 | -3 | 0.738 |
PIM1 |
0.823 | 0.066 | -3 | 0.727 |
FAM20C |
0.823 | 0.054 | 2 | 0.572 |
TSSK1 |
0.823 | 0.120 | -3 | 0.827 |
P90RSK |
0.822 | 0.040 | -3 | 0.740 |
TGFBR2 |
0.822 | -0.043 | -2 | 0.747 |
RSK3 |
0.822 | 0.043 | -3 | 0.733 |
CAMLCK |
0.822 | -0.002 | -2 | 0.785 |
PKN2 |
0.821 | 0.018 | -3 | 0.773 |
DYRK2 |
0.821 | 0.124 | 1 | 0.716 |
NIK |
0.821 | -0.037 | -3 | 0.815 |
JNK2 |
0.820 | 0.154 | 1 | 0.643 |
ICK |
0.820 | 0.063 | -3 | 0.792 |
PKCD |
0.820 | 0.054 | 2 | 0.797 |
JNK3 |
0.820 | 0.138 | 1 | 0.679 |
NEK7 |
0.819 | -0.110 | -3 | 0.774 |
DAPK2 |
0.819 | -0.007 | -3 | 0.812 |
PDHK1 |
0.819 | -0.177 | 1 | 0.808 |
MLK1 |
0.819 | -0.081 | 2 | 0.822 |
SRPK2 |
0.819 | 0.073 | -3 | 0.640 |
CDK8 |
0.819 | 0.070 | 1 | 0.674 |
BCKDK |
0.818 | -0.076 | -1 | 0.778 |
GRK6 |
0.818 | -0.021 | 1 | 0.794 |
PKACG |
0.818 | 0.045 | -2 | 0.721 |
AMPKA2 |
0.817 | 0.049 | -3 | 0.768 |
RIPK3 |
0.817 | -0.098 | 3 | 0.677 |
NIM1 |
0.817 | 0.024 | 3 | 0.731 |
P70S6KB |
0.817 | 0.010 | -3 | 0.744 |
GRK7 |
0.817 | 0.071 | 1 | 0.733 |
AURC |
0.817 | 0.042 | -2 | 0.615 |
QSK |
0.817 | 0.084 | 4 | 0.835 |
MAPKAPK3 |
0.816 | -0.015 | -3 | 0.731 |
LATS1 |
0.816 | 0.081 | -3 | 0.807 |
PKCB |
0.816 | 0.073 | 2 | 0.766 |
TGFBR1 |
0.816 | 0.052 | -2 | 0.760 |
CDK5 |
0.816 | 0.117 | 1 | 0.709 |
MAPKAPK2 |
0.816 | 0.026 | -3 | 0.689 |
LATS2 |
0.816 | -0.021 | -5 | 0.698 |
CDK1 |
0.815 | 0.098 | 1 | 0.662 |
MLK3 |
0.815 | 0.013 | 2 | 0.759 |
SRPK3 |
0.815 | 0.051 | -3 | 0.680 |
CDK19 |
0.814 | 0.074 | 1 | 0.640 |
MLK2 |
0.814 | -0.023 | 2 | 0.825 |
CDK7 |
0.814 | 0.066 | 1 | 0.694 |
CAMK2D |
0.814 | -0.048 | -3 | 0.788 |
MARK3 |
0.814 | 0.084 | 4 | 0.797 |
IRE1 |
0.814 | -0.029 | 1 | 0.762 |
P38B |
0.814 | 0.135 | 1 | 0.681 |
CDK18 |
0.813 | 0.112 | 1 | 0.635 |
P38A |
0.813 | 0.117 | 1 | 0.734 |
RSK4 |
0.813 | 0.061 | -3 | 0.706 |
ALK4 |
0.813 | 0.004 | -2 | 0.789 |
TTBK2 |
0.813 | -0.110 | 2 | 0.729 |
ULK1 |
0.813 | -0.169 | -3 | 0.740 |
P38G |
0.812 | 0.116 | 1 | 0.581 |
MASTL |
0.812 | -0.198 | -2 | 0.759 |
GRK4 |
0.811 | -0.102 | -2 | 0.803 |
CLK2 |
0.811 | 0.121 | -3 | 0.706 |
PKCG |
0.811 | 0.028 | 2 | 0.757 |
PKG2 |
0.811 | 0.076 | -2 | 0.664 |
NEK9 |
0.811 | -0.107 | 2 | 0.840 |
PKCA |
0.810 | 0.045 | 2 | 0.746 |
QIK |
0.810 | -0.017 | -3 | 0.771 |
MNK2 |
0.810 | 0.016 | -2 | 0.731 |
PAK1 |
0.810 | -0.015 | -2 | 0.713 |
PKACB |
0.810 | 0.060 | -2 | 0.638 |
HIPK2 |
0.810 | 0.122 | 1 | 0.639 |
WNK3 |
0.810 | -0.205 | 1 | 0.772 |
CDK3 |
0.810 | 0.123 | 1 | 0.606 |
SGK3 |
0.810 | 0.079 | -3 | 0.721 |
PKR |
0.809 | 0.018 | 1 | 0.809 |
MARK2 |
0.809 | 0.061 | 4 | 0.764 |
HIPK1 |
0.809 | 0.114 | 1 | 0.731 |
BRSK1 |
0.809 | 0.021 | -3 | 0.738 |
CAMK2A |
0.809 | 0.000 | 2 | 0.734 |
SIK |
0.809 | 0.038 | -3 | 0.700 |
ATM |
0.808 | -0.047 | 1 | 0.712 |
CDK13 |
0.808 | 0.056 | 1 | 0.673 |
CLK1 |
0.807 | 0.067 | -3 | 0.695 |
ANKRD3 |
0.807 | -0.161 | 1 | 0.797 |
CAMK2B |
0.807 | -0.020 | 2 | 0.723 |
CLK4 |
0.807 | 0.042 | -3 | 0.712 |
ERK1 |
0.807 | 0.092 | 1 | 0.662 |
PRP4 |
0.807 | 0.145 | -3 | 0.793 |
PRKD3 |
0.807 | 0.024 | -3 | 0.702 |
PLK1 |
0.807 | -0.064 | -2 | 0.743 |
IRE2 |
0.807 | -0.038 | 2 | 0.764 |
PAK3 |
0.806 | -0.051 | -2 | 0.704 |
PRKX |
0.806 | 0.084 | -3 | 0.636 |
MELK |
0.806 | -0.021 | -3 | 0.755 |
ACVR2B |
0.806 | -0.003 | -2 | 0.760 |
AKT2 |
0.805 | 0.056 | -3 | 0.650 |
YSK4 |
0.805 | -0.062 | 1 | 0.738 |
DLK |
0.805 | -0.234 | 1 | 0.775 |
ALK2 |
0.805 | 0.013 | -2 | 0.766 |
CDK2 |
0.805 | 0.041 | 1 | 0.724 |
VRK2 |
0.804 | -0.103 | 1 | 0.827 |
MSK2 |
0.804 | -0.040 | -3 | 0.697 |
CDK17 |
0.804 | 0.081 | 1 | 0.585 |
MNK1 |
0.804 | 0.003 | -2 | 0.756 |
PKCZ |
0.804 | -0.008 | 2 | 0.796 |
NUAK1 |
0.804 | -0.043 | -3 | 0.731 |
RIPK1 |
0.804 | -0.210 | 1 | 0.761 |
NEK2 |
0.804 | -0.023 | 2 | 0.809 |
DYRK1A |
0.804 | 0.083 | 1 | 0.747 |
ACVR2A |
0.804 | -0.021 | -2 | 0.742 |
MARK1 |
0.803 | 0.028 | 4 | 0.810 |
SSTK |
0.803 | 0.120 | 4 | 0.824 |
PKCH |
0.803 | -0.011 | 2 | 0.742 |
MLK4 |
0.803 | -0.075 | 2 | 0.746 |
MPSK1 |
0.803 | 0.129 | 1 | 0.749 |
CDK9 |
0.803 | 0.050 | 1 | 0.678 |
MSK1 |
0.802 | 0.001 | -3 | 0.703 |
P38D |
0.802 | 0.121 | 1 | 0.595 |
AURB |
0.802 | -0.012 | -2 | 0.601 |
CDK12 |
0.802 | 0.062 | 1 | 0.647 |
PAK6 |
0.802 | 0.021 | -2 | 0.610 |
DYRK4 |
0.802 | 0.101 | 1 | 0.651 |
DNAPK |
0.801 | 0.001 | 1 | 0.667 |
MEK1 |
0.801 | -0.161 | 2 | 0.811 |
SMG1 |
0.801 | -0.062 | 1 | 0.734 |
PIM2 |
0.801 | 0.023 | -3 | 0.703 |
MYLK4 |
0.800 | -0.039 | -2 | 0.709 |
CAMK4 |
0.800 | -0.134 | -3 | 0.748 |
CDK16 |
0.800 | 0.105 | 1 | 0.602 |
BRSK2 |
0.800 | -0.054 | -3 | 0.756 |
TLK2 |
0.800 | -0.060 | 1 | 0.739 |
CHAK1 |
0.799 | -0.107 | 2 | 0.765 |
CK2A2 |
0.799 | 0.108 | 1 | 0.729 |
BMPR1A |
0.799 | 0.041 | 1 | 0.748 |
DCAMKL1 |
0.799 | 0.008 | -3 | 0.736 |
CHK1 |
0.799 | -0.051 | -3 | 0.779 |
JNK1 |
0.799 | 0.103 | 1 | 0.637 |
ERK2 |
0.798 | 0.033 | 1 | 0.707 |
PASK |
0.798 | 0.040 | -3 | 0.800 |
MST3 |
0.798 | 0.050 | 2 | 0.846 |
GRK2 |
0.798 | -0.063 | -2 | 0.698 |
PLK3 |
0.798 | -0.079 | 2 | 0.741 |
CK1E |
0.798 | -0.039 | -3 | 0.438 |
HIPK3 |
0.798 | 0.072 | 1 | 0.723 |
GSK3A |
0.797 | 0.066 | 4 | 0.432 |
PHKG1 |
0.797 | -0.088 | -3 | 0.765 |
DRAK1 |
0.797 | -0.077 | 1 | 0.707 |
DYRK1B |
0.797 | 0.070 | 1 | 0.681 |
PKACA |
0.796 | 0.046 | -2 | 0.600 |
MAK |
0.795 | 0.162 | -2 | 0.715 |
CDK14 |
0.795 | 0.065 | 1 | 0.672 |
MEKK2 |
0.795 | -0.048 | 2 | 0.808 |
PLK4 |
0.795 | -0.088 | 2 | 0.614 |
PAK2 |
0.794 | -0.105 | -2 | 0.688 |
AURA |
0.794 | -0.042 | -2 | 0.554 |
WNK4 |
0.793 | -0.078 | -2 | 0.823 |
BRAF |
0.793 | -0.094 | -4 | 0.818 |
DYRK3 |
0.793 | 0.055 | 1 | 0.728 |
IRAK4 |
0.792 | -0.056 | 1 | 0.761 |
PERK |
0.792 | -0.140 | -2 | 0.785 |
MEKK3 |
0.792 | -0.161 | 1 | 0.752 |
CDK10 |
0.792 | 0.074 | 1 | 0.658 |
CAMK1G |
0.792 | -0.063 | -3 | 0.702 |
ERK7 |
0.792 | 0.057 | 2 | 0.565 |
NEK5 |
0.792 | -0.058 | 1 | 0.781 |
TAO3 |
0.791 | -0.023 | 1 | 0.756 |
GAK |
0.791 | 0.037 | 1 | 0.811 |
GSK3B |
0.791 | 0.005 | 4 | 0.423 |
HRI |
0.791 | -0.175 | -2 | 0.797 |
PKCT |
0.790 | -0.016 | 2 | 0.751 |
ZAK |
0.790 | -0.139 | 1 | 0.722 |
MEK5 |
0.790 | -0.235 | 2 | 0.813 |
AKT1 |
0.790 | 0.020 | -3 | 0.666 |
MEKK1 |
0.788 | -0.158 | 1 | 0.752 |
CK2A1 |
0.788 | 0.083 | 1 | 0.711 |
SNRK |
0.788 | -0.199 | 2 | 0.661 |
TLK1 |
0.787 | -0.141 | -2 | 0.795 |
SMMLCK |
0.787 | -0.063 | -3 | 0.762 |
GRK3 |
0.787 | -0.052 | -2 | 0.663 |
PINK1 |
0.786 | -0.175 | 1 | 0.809 |
PKCE |
0.786 | 0.029 | 2 | 0.744 |
MAPKAPK5 |
0.786 | -0.129 | -3 | 0.671 |
DCAMKL2 |
0.786 | -0.065 | -3 | 0.752 |
P70S6K |
0.785 | -0.040 | -3 | 0.663 |
TNIK |
0.785 | 0.072 | 3 | 0.799 |
MOK |
0.785 | 0.116 | 1 | 0.761 |
AKT3 |
0.784 | 0.056 | -3 | 0.597 |
SGK1 |
0.784 | 0.064 | -3 | 0.578 |
CK1D |
0.784 | -0.061 | -3 | 0.382 |
EEF2K |
0.784 | -0.007 | 3 | 0.795 |
CK1G1 |
0.784 | -0.078 | -3 | 0.425 |
TAO2 |
0.783 | -0.076 | 2 | 0.845 |
LKB1 |
0.783 | -0.036 | -3 | 0.783 |
DAPK3 |
0.782 | -0.019 | -3 | 0.740 |
PKCI |
0.782 | -0.048 | 2 | 0.759 |
MEKK6 |
0.782 | -0.025 | 1 | 0.762 |
GCK |
0.782 | -0.007 | 1 | 0.770 |
CAMK1D |
0.781 | -0.034 | -3 | 0.637 |
PDK1 |
0.781 | -0.071 | 1 | 0.747 |
NEK11 |
0.781 | -0.155 | 1 | 0.747 |
MST2 |
0.781 | -0.054 | 1 | 0.768 |
CDK6 |
0.781 | 0.053 | 1 | 0.649 |
PHKG2 |
0.781 | -0.089 | -3 | 0.736 |
CK1A2 |
0.781 | -0.068 | -3 | 0.383 |
CAMKK1 |
0.780 | -0.144 | -2 | 0.679 |
HGK |
0.780 | 0.001 | 3 | 0.790 |
TTBK1 |
0.780 | -0.180 | 2 | 0.648 |
NEK8 |
0.779 | -0.179 | 2 | 0.821 |
VRK1 |
0.779 | -0.046 | 2 | 0.860 |
MINK |
0.778 | -0.008 | 1 | 0.761 |
CAMKK2 |
0.778 | -0.110 | -2 | 0.678 |
PAK5 |
0.778 | -0.055 | -2 | 0.544 |
ROCK2 |
0.778 | 0.050 | -3 | 0.733 |
CDK4 |
0.778 | 0.049 | 1 | 0.637 |
HPK1 |
0.777 | -0.001 | 1 | 0.766 |
PKN1 |
0.777 | -0.024 | -3 | 0.679 |
DAPK1 |
0.777 | -0.026 | -3 | 0.723 |
PLK2 |
0.777 | -0.026 | -3 | 0.720 |
NEK4 |
0.777 | -0.095 | 1 | 0.756 |
KHS1 |
0.776 | 0.059 | 1 | 0.761 |
LRRK2 |
0.776 | -0.104 | 2 | 0.832 |
PAK4 |
0.776 | -0.034 | -2 | 0.544 |
TAK1 |
0.776 | -0.082 | 1 | 0.766 |
PDHK3_TYR |
0.776 | 0.249 | 4 | 0.888 |
MAP3K15 |
0.776 | -0.083 | 1 | 0.712 |
MRCKB |
0.775 | 0.016 | -3 | 0.685 |
PBK |
0.775 | 0.027 | 1 | 0.743 |
BUB1 |
0.774 | 0.046 | -5 | 0.669 |
KHS2 |
0.773 | 0.042 | 1 | 0.772 |
NEK1 |
0.773 | -0.073 | 1 | 0.759 |
IRAK1 |
0.772 | -0.269 | -1 | 0.723 |
SBK |
0.771 | 0.026 | -3 | 0.544 |
MST1 |
0.771 | -0.085 | 1 | 0.757 |
LOK |
0.771 | -0.058 | -2 | 0.718 |
MRCKA |
0.769 | -0.018 | -3 | 0.695 |
YSK1 |
0.769 | -0.044 | 2 | 0.813 |
CAMK1A |
0.768 | -0.039 | -3 | 0.610 |
CHK2 |
0.768 | -0.046 | -3 | 0.595 |
PKG1 |
0.767 | 0.015 | -2 | 0.590 |
DMPK1 |
0.767 | 0.027 | -3 | 0.705 |
HASPIN |
0.767 | -0.000 | -1 | 0.639 |
SLK |
0.764 | -0.113 | -2 | 0.673 |
MEK2 |
0.763 | -0.216 | 2 | 0.787 |
TESK1_TYR |
0.763 | -0.030 | 3 | 0.827 |
STK33 |
0.762 | -0.175 | 2 | 0.612 |
TTK |
0.762 | -0.053 | -2 | 0.765 |
ROCK1 |
0.762 | 0.011 | -3 | 0.697 |
MAP2K4_TYR |
0.762 | -0.027 | -1 | 0.864 |
PKMYT1_TYR |
0.761 | 0.005 | 3 | 0.790 |
EPHA6 |
0.761 | 0.097 | -1 | 0.855 |
BMPR2_TYR |
0.760 | 0.008 | -1 | 0.866 |
MAP2K6_TYR |
0.760 | -0.030 | -1 | 0.865 |
PDHK4_TYR |
0.760 | -0.027 | 2 | 0.841 |
OSR1 |
0.759 | -0.089 | 2 | 0.791 |
LIMK2_TYR |
0.759 | 0.037 | -3 | 0.842 |
MYO3B |
0.758 | -0.010 | 2 | 0.817 |
MAP2K7_TYR |
0.758 | -0.152 | 2 | 0.831 |
PDHK1_TYR |
0.758 | -0.053 | -1 | 0.876 |
CRIK |
0.757 | 0.006 | -3 | 0.672 |
BIKE |
0.755 | -0.011 | 1 | 0.693 |
NEK3 |
0.755 | -0.159 | 1 | 0.712 |
RIPK2 |
0.753 | -0.316 | 1 | 0.674 |
PINK1_TYR |
0.753 | -0.177 | 1 | 0.802 |
EPHB4 |
0.753 | 0.007 | -1 | 0.824 |
MYO3A |
0.753 | -0.058 | 1 | 0.759 |
ASK1 |
0.751 | -0.142 | 1 | 0.701 |
LIMK1_TYR |
0.750 | -0.130 | 2 | 0.836 |
TAO1 |
0.750 | -0.095 | 1 | 0.684 |
TXK |
0.750 | 0.059 | 1 | 0.797 |
ABL2 |
0.749 | 0.019 | -1 | 0.810 |
RET |
0.749 | -0.101 | 1 | 0.760 |
ROS1 |
0.749 | -0.046 | 3 | 0.692 |
TYK2 |
0.747 | -0.131 | 1 | 0.758 |
FGR |
0.747 | -0.055 | 1 | 0.809 |
TYRO3 |
0.747 | -0.104 | 3 | 0.715 |
YANK3 |
0.747 | -0.098 | 2 | 0.413 |
LCK |
0.746 | 0.033 | -1 | 0.845 |
ALPHAK3 |
0.746 | -0.131 | -1 | 0.770 |
ABL1 |
0.746 | 0.006 | -1 | 0.805 |
YES1 |
0.746 | -0.038 | -1 | 0.841 |
CK1A |
0.746 | -0.088 | -3 | 0.293 |
JAK2 |
0.746 | -0.091 | 1 | 0.753 |
DDR1 |
0.745 | -0.106 | 4 | 0.813 |
CSF1R |
0.745 | -0.079 | 3 | 0.698 |
MST1R |
0.745 | -0.155 | 3 | 0.730 |
BLK |
0.745 | 0.054 | -1 | 0.839 |
FER |
0.744 | -0.094 | 1 | 0.825 |
HCK |
0.744 | -0.037 | -1 | 0.835 |
AAK1 |
0.742 | 0.031 | 1 | 0.602 |
TNK2 |
0.742 | -0.031 | 3 | 0.681 |
EPHA4 |
0.742 | -0.050 | 2 | 0.743 |
SRMS |
0.742 | -0.059 | 1 | 0.804 |
ITK |
0.741 | -0.048 | -1 | 0.795 |
EPHB1 |
0.740 | -0.070 | 1 | 0.794 |
TNNI3K_TYR |
0.740 | 0.007 | 1 | 0.763 |
JAK3 |
0.740 | -0.122 | 1 | 0.733 |
INSRR |
0.739 | -0.112 | 3 | 0.674 |
EPHB2 |
0.739 | -0.043 | -1 | 0.808 |
EPHB3 |
0.738 | -0.066 | -1 | 0.812 |
FYN |
0.738 | 0.017 | -1 | 0.823 |
JAK1 |
0.737 | -0.038 | 1 | 0.695 |
BMX |
0.736 | -0.039 | -1 | 0.727 |
MERTK |
0.735 | -0.066 | 3 | 0.693 |
STLK3 |
0.735 | -0.220 | 1 | 0.691 |
TNK1 |
0.735 | -0.075 | 3 | 0.695 |
FGFR2 |
0.734 | -0.166 | 3 | 0.730 |
KDR |
0.734 | -0.124 | 3 | 0.671 |
KIT |
0.734 | -0.148 | 3 | 0.705 |
NEK10_TYR |
0.733 | -0.110 | 1 | 0.665 |
AXL |
0.732 | -0.124 | 3 | 0.694 |
WEE1_TYR |
0.732 | -0.097 | -1 | 0.742 |
MET |
0.732 | -0.110 | 3 | 0.694 |
TEC |
0.732 | -0.089 | -1 | 0.727 |
BTK |
0.731 | -0.163 | -1 | 0.759 |
FLT3 |
0.731 | -0.187 | 3 | 0.708 |
ALK |
0.730 | -0.122 | 3 | 0.637 |
EPHA7 |
0.730 | -0.079 | 2 | 0.753 |
FRK |
0.730 | -0.079 | -1 | 0.837 |
PDGFRB |
0.730 | -0.226 | 3 | 0.720 |
TEK |
0.729 | -0.204 | 3 | 0.657 |
FGFR1 |
0.729 | -0.180 | 3 | 0.693 |
LTK |
0.729 | -0.110 | 3 | 0.665 |
LYN |
0.728 | -0.082 | 3 | 0.634 |
DDR2 |
0.727 | -0.035 | 3 | 0.664 |
PTK6 |
0.727 | -0.189 | -1 | 0.737 |
EPHA3 |
0.726 | -0.140 | 2 | 0.721 |
EPHA1 |
0.725 | -0.115 | 3 | 0.673 |
SRC |
0.725 | -0.067 | -1 | 0.818 |
PTK2B |
0.724 | -0.074 | -1 | 0.774 |
INSR |
0.723 | -0.165 | 3 | 0.651 |
FGFR3 |
0.723 | -0.179 | 3 | 0.700 |
FLT1 |
0.723 | -0.169 | -1 | 0.827 |
ERBB2 |
0.723 | -0.192 | 1 | 0.711 |
MATK |
0.723 | -0.118 | -1 | 0.739 |
PDGFRA |
0.722 | -0.278 | 3 | 0.715 |
PTK2 |
0.721 | -0.013 | -1 | 0.790 |
NTRK1 |
0.721 | -0.238 | -1 | 0.803 |
CK1G3 |
0.721 | -0.102 | -3 | 0.246 |
NTRK3 |
0.720 | -0.148 | -1 | 0.767 |
EPHA5 |
0.720 | -0.112 | 2 | 0.729 |
EPHA8 |
0.720 | -0.101 | -1 | 0.805 |
EGFR |
0.719 | -0.103 | 1 | 0.615 |
CSK |
0.718 | -0.132 | 2 | 0.759 |
NTRK2 |
0.718 | -0.249 | 3 | 0.671 |
SYK |
0.718 | -0.035 | -1 | 0.787 |
FLT4 |
0.716 | -0.243 | 3 | 0.679 |
FGFR4 |
0.713 | -0.130 | -1 | 0.772 |
YANK2 |
0.712 | -0.126 | 2 | 0.424 |
EPHA2 |
0.710 | -0.112 | -1 | 0.775 |
IGF1R |
0.708 | -0.163 | 3 | 0.594 |
CK1G2 |
0.707 | -0.098 | -3 | 0.338 |
MUSK |
0.706 | -0.167 | 1 | 0.618 |
ERBB4 |
0.705 | -0.098 | 1 | 0.642 |
FES |
0.695 | -0.161 | -1 | 0.711 |
ZAP70 |
0.694 | -0.073 | -1 | 0.714 |