Motif 730 (n=145)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0G2JPF8 | HNRNPCL4 | S196 | ochoa | Heterogeneous nuclear ribonucleoprotein C like 4 | None |
| A6NKT7 | RGPD3 | T1185 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8MSY1 | STIMATE-MUSTN1 | S253 | ochoa | Musculoskeletal embryonic nuclear protein 1 | None |
| B2RXH8 | HNRNPCL2 | S196 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNP C-like-2) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| B7ZW38 | HNRNPCL3 | S196 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 3 | None |
| F5H5P2 | None | S373 | ochoa | 2-oxoisovalerate dehydrogenase subunit alpha (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) | Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000256|ARBA:ARBA00037052, ECO:0000256|RuleBase:RU365014}. |
| O14715 | RGPD8 | T1184 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14795 | UNC13B | S301 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O15042 | U2SURP | S97 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O43707 | ACTN4 | S423 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43707 | ACTN4 | S461 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43719 | HTATSF1 | S485 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O60282 | KIF5C | S835 | ochoa | Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1) | Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). {ECO:0000250|UniProtKB:P28738, ECO:0000250|UniProtKB:P56536, ECO:0000269|PubMed:24812067}. |
| O60812 | HNRNPCL1 | S196 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| O60841 | EIF5B | S66 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75691 | UTP20 | S783 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
| O95171 | SCEL | S344 | ochoa | Sciellin | May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. |
| O95239 | KIF4A | S1038 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95239 | KIF4A | S1136 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95394 | PGM3 | S498 | ochoa | Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3) | Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. {ECO:0000303|PubMed:24589341, ECO:0000303|PubMed:24698316, ECO:0000303|PubMed:24931394}. |
| P01189 | POMC | S168 | psp | Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin] | [Corticotropin]: Stimulates the adrenal glands to release cortisol.; FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: [Beta-endorphin]: Endogenous orexigenic opiate.; FUNCTION: [Met-enkephalin]: Endogenous opiate. |
| P02545 | LMNA | S143 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02775 | PPBP | S70 | ochoa | Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))] | LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}. |
| P07910 | HNRNPC | S209 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P08670 | VIM | S278 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P0DJD0 | RGPD1 | T1169 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | T1177 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DMR1 | HNRNPCL4 | S196 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 4 | None |
| P10451 | SPP1 | S254 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11055 | MYH3 | S1777 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11171 | EPB41 | S144 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P11277 | SPTB | S2034 | ochoa | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P12694 | BCKDHA | S339 | ochoa | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha) | Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000269|PubMed:10745006, ECO:0000269|PubMed:7883996, ECO:0000269|PubMed:9582350}. |
| P12814 | ACTN1 | S404 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12814 | ACTN1 | S442 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12882 | MYH1 | S1780 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1776 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1778 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1779 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P15374 | UCHL3 | S151 | ochoa | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0000269|PubMed:9790970}. |
| P21980 | TGM2 | S385 | ochoa | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696, PubMed:31991788, PubMed:9252372). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:27270573, PubMed:28198360, PubMed:7935379, PubMed:9252372). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:20547769, PubMed:9623982). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}. |
| P25205 | MCM3 | S734 | ochoa | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P31327 | CPS1 | S898 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P33176 | KIF5B | S833 | ochoa | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P33981 | TTK | S362 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35579 | MYH9 | S1803 | psp | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35609 | ACTN2 | S411 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35609 | ACTN2 | S449 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P37275 | ZEB1 | S1100 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P38398 | BRCA1 | S1239 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42566 | EPS15 | S485 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P45974 | USP5 | S149 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P46821 | MAP1B | S995 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46934 | NEDD4 | S888 | ochoa | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:19920177, PubMed:21399620, PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes (PubMed:21765395). Promotes ubiquitination of RAPGEF2 (PubMed:11598133). According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (PubMed:20086093). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Ubiquitinates DAZAP2, leading to its proteasomal degradation (PubMed:11342538). Ubiquitinates POLR2A (PubMed:19920177). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (PubMed:32101753). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:11598133, ECO:0000269|PubMed:17218260, ECO:0000269|PubMed:18562292, ECO:0000269|PubMed:21399620, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:23644597, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:32101753}.; FUNCTION: (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding. {ECO:0000269|PubMed:12559917, ECO:0000269|PubMed:18305167}. |
| P46939 | UTRN | S295 | ochoa|psp | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P49768 | PSEN1 | S319 | ochoa|psp | Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}. |
| P49792 | RANBP2 | T2160 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51858 | HDGF | S132 | ochoa|psp | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}. |
| P52701 | MSH6 | S935 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P57729 | RAB38 | S187 | ochoa | Ras-related protein Rab-38 (EC 3.6.5.2) (Melanoma antigen NY-MEL-1) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB38 may be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:Q13637, ECO:0000250|UniProtKB:Q8QZZ8, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:23084991}. |
| P61981 | YWHAG | S113 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62495 | ETF1 | S123 | ochoa | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793, PubMed:7990965). The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:26245381, PubMed:27863242, PubMed:36638793). ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:26245381, PubMed:27863242, PubMed:36638793). Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:10676813, PubMed:16777602, PubMed:26245381, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:10676813, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:26245381, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:7990965}. |
| P78527 | PRKDC | S314 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P82094 | TMF1 | S217 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| P84098 | RPL19 | S164 | ochoa | Large ribosomal subunit protein eL19 (60S ribosomal protein L19) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q00341 | HDLBP | S756 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q01484 | ANK2 | S2127 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01970 | PLCB3 | S1107 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}. |
| Q02952 | AKAP12 | S1727 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S1755 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q04917 | YWHAH | S145 | ochoa | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Q08043 | ACTN3 | S418 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q0ZGT2 | NEXN | S442 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12840 | KIF5A | S831 | ochoa | Kinesin heavy chain isoform 5A (EC 5.6.1.3) (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) | Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. {ECO:0000250|UniProtKB:P33175, ECO:0000250|UniProtKB:Q6QLM7}. |
| Q13342 | SP140 | S291 | ochoa | Nuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa) | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382). {ECO:0000269|PubMed:24267382, ECO:0000269|PubMed:8910577, ECO:0000303|PubMed:8910577}. |
| Q13428 | TCOF1 | S369 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14839 | CHD4 | S1244 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
| Q16543 | CDC37 | S300 | ochoa | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. |
| Q16568 | CARTPT | S48 | ochoa | Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39); CART(42-89)] | Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro. {ECO:0000269|PubMed:9590691}. |
| Q16836 | HADH | S73 | ochoa | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity). {ECO:0000250|UniProtKB:Q61425, ECO:0000269|PubMed:10231530, ECO:0000269|PubMed:11489939, ECO:0000269|PubMed:16725361}. |
| Q2T9K0 | TMEM44 | S333 | ochoa | Transmembrane protein 44 | None |
| Q2VIQ3 | KIF4B | S1038 | ochoa | Chromosome-associated kinesin KIF4B (Chromokinesin-B) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (By similarity). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:O95239, ECO:0000250|UniProtKB:P33174}. |
| Q58FF8 | HSP90AB2P | S266 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5JSH3 | WDR44 | S27 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5VU43 | PDE4DIP | S235 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q5VUA4 | ZNF318 | S1761 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VUB5 | FAM171A1 | S426 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q63HQ0 | AP1AR | S148 | ochoa | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
| Q63HR2 | TNS2 | S646 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q68DQ2 | CRYBG3 | S912 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6GYQ0 | RALGAPA1 | S503 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6PJG2 | MIDEAS | S923 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q86TL2 | STIMATE | S253 | ochoa | Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110) | Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574). {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}. |
| Q86UP3 | ZFHX4 | S1279 | ochoa | Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) | May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}. |
| Q86XA9 | HEATR5A | S1647 | ochoa | HEAT repeat-containing protein 5A | None |
| Q8IVM0 | CCDC50 | S143 | ochoa | Coiled-coil domain-containing protein 50 (Protein Ymer) | Involved in EGFR signaling. {ECO:0000269|PubMed:15314609}. |
| Q8IYF3 | TEX11 | S178 | ochoa | Testis-expressed protein 11 (Protein ZIP4 homolog) (ZIP4H) | Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. {ECO:0000250|UniProtKB:Q14AT2}. |
| Q8IZ21 | PHACTR4 | T547 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8N3D4 | EHBP1L1 | S661 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N6T3 | ARFGAP1 | S246 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8N8E2 | ZNF513 | S89 | ochoa | Zinc finger protein 513 | Transcriptional regulator that plays a role in retinal development and maintenance. {ECO:0000269|PubMed:20797688}. |
| Q8WUZ0 | BCL7C | S156 | ochoa | B-cell CLL/lymphoma 7 protein family member C | May play an anti-apoptotic role. {ECO:0000250}. |
| Q8WYP5 | AHCTF1 | S1806 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92681 | RSC1A1 | S366 | psp | Regulatory solute carrier protein family 1 member 1 (Transporter regulator RS1) (hRS1) | Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network. {ECO:0000269|PubMed:14724758, ECO:0000269|PubMed:16788146, ECO:0000269|PubMed:8836035}. |
| Q92783 | STAM | S191 | ochoa | Signal transducing adapter molecule 1 (STAM-1) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.; FUNCTION: (Microbial infection) Plays an important role in Dengue virus entry. {ECO:0000269|PubMed:29742433}. |
| Q96AQ6 | PBXIP1 | S551 | ochoa | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96II8 | LRCH3 | S318 | ochoa | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}. |
| Q96JP2 | MYO15B | S1502 | ochoa | Unconventional myosin-XVB (Myosin XVBP) (Unconventional myosin-15B) | None |
| Q96ST3 | SIN3A | S938 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q99666 | RGPD5 | T1184 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BQS8 | FYCO1 | S609 | ochoa | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
| Q9BY89 | KIAA1671 | S1271 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZI7 | UPF3B | S409 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9BZL6 | PRKD2 | S353 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9H0S4 | DDX47 | S424 | ochoa | Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47) | Required for efficient ribosome biogenesis (By similarity). May have a role in mRNA splicing (PubMed:16963496). Involved in apoptosis (PubMed:15977068). {ECO:0000250|UniProtKB:Q9VIF6, ECO:0000269|PubMed:15977068, ECO:0000269|PubMed:16963496}. |
| Q9NP62 | GCM1 | S177 | psp | Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1) | Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}. |
| Q9NQW6 | ANLN | S65 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NRA8 | EIF4ENIF1 | S426 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NTJ3 | SMC4 | S355 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9NWQ8 | PAG1 | S201 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9P2N5 | RBM27 | S128 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9UHB6 | LIMA1 | S55 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UJ70 | NAGK | S70 | ochoa | N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60) | Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:22692205). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575). {ECO:0000250|UniProtKB:Q9QZ08, ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:36002575}. |
| Q9UKA4 | AKAP11 | S1289 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKX2 | MYH2 | S1782 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S1780 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UPN4 | CEP131 | S731 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9Y623 | MYH4 | S1780 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6D9 | MAD1L1 | S598 | psp | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| Q9Y6R0 | NUMBL | S224 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| U3KPZ7 | LOC127814297 | S128 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
| P50395 | GDI2 | S396 | Sugiyama | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P52907 | CAPZA1 | S123 | Sugiyama | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| P13639 | EEF2 | Y634 | Sugiyama | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| O43526 | KCNQ2 | S558 | SIGNOR|iPTMNet|EPSD | Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961). {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}. |
| O75116 | ROCK2 | S724 | Sugiyama | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| Q99961 | SH3GL1 | S108 | Sugiyama | Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}. |
| Q9BXP5 | SRRT | S703 | Sugiyama | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q07666 | KHDRBS1 | S117 | Sugiyama | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| P04040 | CAT | S120 | Sugiyama | Catalase (EC 1.11.1.6) | Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}. |
| P55072 | VCP | S459 | Sugiyama | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| Q8NE63 | HIPK4 | S298 | Sugiyama | Homeodomain-interacting protein kinase 4 (EC 2.7.11.1) | Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). {ECO:0000250, ECO:0000305}. |
| Q8NEY8 | PPHLN1 | S329 | Sugiyama | Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}. |
| Q9H1R3 | MYLK2 | S225 | Sugiyama | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
| Q15643 | TRIP11 | S1376 | Sugiyama | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-199991 | Membrane Trafficking | 0.000001 | 5.886 |
| R-HSA-390522 | Striated Muscle Contraction | 0.000004 | 5.399 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.000016 | 4.800 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.000017 | 4.770 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.000023 | 4.629 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.000037 | 4.436 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.000047 | 4.325 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.000059 | 4.226 |
| R-HSA-983189 | Kinesins | 0.000076 | 4.117 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.000087 | 4.062 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.000135 | 3.869 |
| R-HSA-373753 | Nephrin family interactions | 0.000135 | 3.869 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.000158 | 3.802 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.000181 | 3.742 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.000181 | 3.742 |
| R-HSA-177929 | Signaling by EGFR | 0.000531 | 3.275 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.000542 | 3.266 |
| R-HSA-182971 | EGFR downregulation | 0.000591 | 3.229 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.000676 | 3.170 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.000968 | 3.014 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.001147 | 2.940 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.004778 | 2.321 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.004912 | 2.309 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.004765 | 2.322 |
| R-HSA-264876 | Insulin processing | 0.004778 | 2.321 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.005727 | 2.242 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.007641 | 2.117 |
| R-HSA-8852135 | Protein ubiquitination | 0.010468 | 1.980 |
| R-HSA-373760 | L1CAM interactions | 0.010825 | 1.966 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.013149 | 1.881 |
| R-HSA-6806834 | Signaling by MET | 0.012729 | 1.895 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 0.014644 | 1.834 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 0.014644 | 1.834 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 0.014644 | 1.834 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.016210 | 1.790 |
| R-HSA-8876725 | Protein methylation | 0.016210 | 1.790 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.016210 | 1.790 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.016210 | 1.790 |
| R-HSA-5579031 | Defective ACTH causes obesity and POMCD | 0.020042 | 1.698 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.020042 | 1.698 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.020042 | 1.698 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.020042 | 1.698 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 0.019544 | 1.709 |
| R-HSA-9675108 | Nervous system development | 0.020295 | 1.693 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.021157 | 1.675 |
| R-HSA-68877 | Mitotic Prometaphase | 0.021591 | 1.666 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.023139 | 1.636 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.023139 | 1.636 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.023847 | 1.623 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.024672 | 1.608 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.026983 | 1.569 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.029913 | 1.524 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.028922 | 1.539 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.029913 | 1.524 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.027027 | 1.568 |
| R-HSA-422475 | Axon guidance | 0.029855 | 1.525 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.028429 | 1.546 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.030196 | 1.520 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.031065 | 1.508 |
| R-HSA-397014 | Muscle contraction | 0.031562 | 1.501 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.039685 | 1.401 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.039685 | 1.401 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.039685 | 1.401 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.039685 | 1.401 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.039685 | 1.401 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.039685 | 1.401 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.039685 | 1.401 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.039685 | 1.401 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.039685 | 1.401 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.039685 | 1.401 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.039685 | 1.401 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.042239 | 1.374 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.039899 | 1.399 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 0.035374 | 1.451 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.049556 | 1.305 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.049360 | 1.307 |
| R-HSA-68875 | Mitotic Prophase | 0.048194 | 1.317 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.049360 | 1.307 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.044629 | 1.350 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.044629 | 1.350 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.049556 | 1.305 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.049887 | 1.302 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.046950 | 1.328 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.044629 | 1.350 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.045031 | 1.346 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.051388 | 1.289 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.052090 | 1.283 |
| R-HSA-9865113 | Loss-of-function mutations in DBT cause MSUD2 | 0.077805 | 1.109 |
| R-HSA-9907570 | Loss-of-function mutations in DLD cause MSUD3/DLDD | 0.077805 | 1.109 |
| R-HSA-9865125 | Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD | 0.087098 | 1.060 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 0.087098 | 1.060 |
| R-HSA-9912481 | Branched-chain ketoacid dehydrogenase kinase deficiency | 0.087098 | 1.060 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.140931 | 0.851 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.140931 | 0.851 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 0.149591 | 0.825 |
| R-HSA-9859138 | BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV | 0.166652 | 0.778 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.207831 | 0.682 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.215820 | 0.666 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.223730 | 0.650 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.223730 | 0.650 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.223730 | 0.650 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.223730 | 0.650 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.223730 | 0.650 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.239312 | 0.621 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.239312 | 0.621 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.269550 | 0.569 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.071062 | 1.148 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.071062 | 1.148 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.151526 | 0.820 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.298593 | 0.525 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.298593 | 0.525 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.162107 | 0.790 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.162107 | 0.790 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.305673 | 0.515 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.172817 | 0.762 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.312681 | 0.505 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.312681 | 0.505 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.198217 | 0.703 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.198217 | 0.703 |
| R-HSA-380287 | Centrosome maturation | 0.205558 | 0.687 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.066548 | 1.177 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.231456 | 0.636 |
| R-HSA-156902 | Peptide chain elongation | 0.257549 | 0.589 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.257549 | 0.589 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.272490 | 0.565 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.231561 | 0.635 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.231561 | 0.635 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.199760 | 0.699 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.199760 | 0.699 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.276921 | 0.558 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.305673 | 0.515 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.265019 | 0.577 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.246353 | 0.608 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.132042 | 0.879 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.132042 | 0.879 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.084720 | 1.072 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.291149 | 0.536 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.110868 | 0.955 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.291149 | 0.536 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 0.149591 | 0.825 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 0.149591 | 0.825 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.299681 | 0.523 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.199760 | 0.699 |
| R-HSA-72172 | mRNA Splicing | 0.078599 | 1.105 |
| R-HSA-202040 | G-protein activation | 0.231561 | 0.635 |
| R-HSA-1221632 | Meiotic synapsis | 0.127442 | 0.895 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.276921 | 0.558 |
| R-HSA-9930044 | Nuclear RNA decay | 0.059960 | 1.222 |
| R-HSA-193048 | Androgen biosynthesis | 0.239312 | 0.621 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.107934 | 0.967 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.103754 | 0.984 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.276224 | 0.559 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 0.101222 | 0.995 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.077805 | 1.109 |
| R-HSA-176974 | Unwinding of DNA | 0.114421 | 0.941 |
| R-HSA-177135 | Conjugation of benzoate with glycine | 0.132183 | 0.879 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.149591 | 0.825 |
| R-HSA-177128 | Conjugation of salicylate with glycine | 0.149591 | 0.825 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.158164 | 0.801 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.207831 | 0.682 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.207831 | 0.682 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.312681 | 0.505 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.207831 | 0.682 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.276921 | 0.558 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.068419 | 1.165 |
| R-HSA-9620244 | Long-term potentiation | 0.269550 | 0.569 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.190909 | 0.719 |
| R-HSA-5358508 | Mismatch Repair | 0.207831 | 0.682 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.305673 | 0.515 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.105405 | 0.977 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.223730 | 0.650 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.246987 | 0.607 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.276921 | 0.558 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.180021 | 0.745 |
| R-HSA-1500620 | Meiosis | 0.242624 | 0.615 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.175055 | 0.757 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.312681 | 0.505 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.287420 | 0.541 |
| R-HSA-8981373 | Intestinal hexose absorption | 0.077805 | 1.109 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 0.105405 | 0.977 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.183373 | 0.737 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 0.191608 | 0.718 |
| R-HSA-156587 | Amino Acid conjugation | 0.215820 | 0.666 |
| R-HSA-159424 | Conjugation of carboxylic acids | 0.215820 | 0.666 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.231561 | 0.635 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.262105 | 0.582 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.238898 | 0.622 |
| R-HSA-68886 | M Phase | 0.053668 | 1.270 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.262105 | 0.582 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.157831 | 0.802 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.114421 | 0.941 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.269550 | 0.569 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.269550 | 0.569 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.191608 | 0.718 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.284218 | 0.546 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.207831 | 0.682 |
| R-HSA-9646399 | Aggrephagy | 0.082714 | 1.082 |
| R-HSA-9675135 | Diseases of DNA repair | 0.104411 | 0.981 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.096297 | 1.016 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.123347 | 0.909 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.149591 | 0.825 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 0.175055 | 0.757 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.215820 | 0.666 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.239312 | 0.621 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.254584 | 0.594 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.124081 | 0.906 |
| R-HSA-429947 | Deadenylation of mRNA | 0.262105 | 0.582 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.276921 | 0.558 |
| R-HSA-69481 | G2/M Checkpoints | 0.057215 | 1.242 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.194558 | 0.711 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.224030 | 0.650 |
| R-HSA-8951664 | Neddylation | 0.228670 | 0.641 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.280477 | 0.552 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.298593 | 0.525 |
| R-HSA-8953854 | Metabolism of RNA | 0.159963 | 0.796 |
| R-HSA-5617833 | Cilium Assembly | 0.163204 | 0.787 |
| R-HSA-68882 | Mitotic Anaphase | 0.092993 | 1.032 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.094250 | 1.026 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.060849 | 1.216 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.077805 | 1.109 |
| R-HSA-8964011 | HDL clearance | 0.087098 | 1.060 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.096297 | 1.016 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 0.114421 | 0.941 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.114421 | 0.941 |
| R-HSA-209952 | Peptide hormone biosynthesis | 0.123347 | 0.909 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.132183 | 0.879 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.149591 | 0.825 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.149591 | 0.825 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.149591 | 0.825 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.166652 | 0.778 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.175055 | 0.757 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.175055 | 0.757 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.125289 | 0.902 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.246353 | 0.608 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.178167 | 0.749 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.057610 | 1.239 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.136543 | 0.865 |
| R-HSA-8963676 | Intestinal absorption | 0.105405 | 0.977 |
| R-HSA-5689877 | Josephin domain DUBs | 0.123347 | 0.909 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.166652 | 0.778 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.191608 | 0.718 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.291442 | 0.535 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.231561 | 0.635 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.276921 | 0.558 |
| R-HSA-9659379 | Sensory processing of sound | 0.220324 | 0.657 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.205558 | 0.687 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.142914 | 0.845 |
| R-HSA-1640170 | Cell Cycle | 0.122575 | 0.912 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.166652 | 0.778 |
| R-HSA-437239 | Recycling pathway of L1 | 0.107626 | 0.968 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.246987 | 0.607 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.276921 | 0.558 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.305673 | 0.515 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.180021 | 0.745 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.120859 | 0.918 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.231561 | 0.635 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.246987 | 0.607 |
| R-HSA-69190 | DNA strand elongation | 0.319620 | 0.495 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.120859 | 0.918 |
| R-HSA-70635 | Urea cycle | 0.276921 | 0.558 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.162107 | 0.790 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.205558 | 0.687 |
| R-HSA-5688426 | Deubiquitination | 0.062049 | 1.207 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.132183 | 0.879 |
| R-HSA-194002 | Glucocorticoid biosynthesis | 0.239312 | 0.621 |
| R-HSA-392499 | Metabolism of proteins | 0.194544 | 0.711 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.057293 | 1.242 |
| R-HSA-597592 | Post-translational protein modification | 0.126404 | 0.898 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.175055 | 0.757 |
| R-HSA-9678110 | Attachment and Entry | 0.183373 | 0.737 |
| R-HSA-9629569 | Protein hydroxylation | 0.223730 | 0.650 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.239312 | 0.621 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.276921 | 0.558 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.075203 | 1.124 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.250083 | 0.602 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.247880 | 0.606 |
| R-HSA-373755 | Semaphorin interactions | 0.162107 | 0.790 |
| R-HSA-180292 | GAB1 signalosome | 0.207831 | 0.682 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.215820 | 0.666 |
| R-HSA-9694614 | Attachment and Entry | 0.239312 | 0.621 |
| R-HSA-114608 | Platelet degranulation | 0.057215 | 1.242 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.166652 | 0.778 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.319620 | 0.495 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.246987 | 0.607 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.085786 | 1.067 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.065801 | 1.182 |
| R-HSA-9663891 | Selective autophagy | 0.257549 | 0.589 |
| R-HSA-75153 | Apoptotic execution phase | 0.104411 | 0.981 |
| R-HSA-3000170 | Syndecan interactions | 0.254584 | 0.594 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.082422 | 1.084 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.079741 | 1.098 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.201883 | 0.695 |
| R-HSA-1500931 | Cell-Cell communication | 0.127455 | 0.895 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.215820 | 0.666 |
| R-HSA-1266738 | Developmental Biology | 0.137625 | 0.861 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.262105 | 0.582 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.262105 | 0.582 |
| R-HSA-162582 | Signal Transduction | 0.230600 | 0.637 |
| R-HSA-109581 | Apoptosis | 0.111189 | 0.954 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.284218 | 0.546 |
| R-HSA-5357801 | Programmed Cell Death | 0.079749 | 1.098 |
| R-HSA-1280218 | Adaptive Immune System | 0.285162 | 0.545 |
| R-HSA-2262752 | Cellular responses to stress | 0.105858 | 0.975 |
| R-HSA-109582 | Hemostasis | 0.066130 | 1.180 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.137650 | 0.861 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.223727 | 0.650 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.133319 | 0.875 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.169234 | 0.772 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.298598 | 0.525 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.209239 | 0.679 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.313445 | 0.504 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.253816 | 0.595 |
| R-HSA-111885 | Opioid Signalling | 0.324562 | 0.489 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.326488 | 0.486 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.326488 | 0.486 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.326488 | 0.486 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.326488 | 0.486 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.326488 | 0.486 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.326488 | 0.486 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.326488 | 0.486 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.326488 | 0.486 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.326488 | 0.486 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.326488 | 0.486 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.326488 | 0.486 |
| R-HSA-449147 | Signaling by Interleukins | 0.331538 | 0.479 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.333288 | 0.477 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.333288 | 0.477 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.333288 | 0.477 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.333288 | 0.477 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.333606 | 0.477 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.335618 | 0.474 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.340020 | 0.468 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.340020 | 0.468 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.340020 | 0.468 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.340020 | 0.468 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.340020 | 0.468 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.342961 | 0.465 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.342961 | 0.465 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.346683 | 0.460 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.346683 | 0.460 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.346683 | 0.460 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.347328 | 0.459 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.349269 | 0.457 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.353281 | 0.452 |
| R-HSA-3371511 | HSF1 activation | 0.353281 | 0.452 |
| R-HSA-6798695 | Neutrophil degranulation | 0.355280 | 0.449 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.357567 | 0.447 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.359811 | 0.444 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.359811 | 0.444 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.359811 | 0.444 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.359811 | 0.444 |
| R-HSA-74160 | Gene expression (Transcription) | 0.363382 | 0.440 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.366277 | 0.436 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.366277 | 0.436 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.366277 | 0.436 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.372056 | 0.429 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.372677 | 0.429 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.372677 | 0.429 |
| R-HSA-201556 | Signaling by ALK | 0.372677 | 0.429 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.372677 | 0.429 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.379013 | 0.421 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.379013 | 0.421 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.379013 | 0.421 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.379013 | 0.421 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.379013 | 0.421 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.379013 | 0.421 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.379013 | 0.421 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.379252 | 0.421 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.379252 | 0.421 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.382838 | 0.417 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.385286 | 0.414 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.385286 | 0.414 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.385286 | 0.414 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.385286 | 0.414 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.385286 | 0.414 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.390358 | 0.409 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.391495 | 0.407 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.391495 | 0.407 |
| R-HSA-3371556 | Cellular response to heat stress | 0.397090 | 0.401 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.397643 | 0.401 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.402839 | 0.395 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.403728 | 0.394 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.403728 | 0.394 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.409752 | 0.387 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.415716 | 0.381 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.415716 | 0.381 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.415716 | 0.381 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.421620 | 0.375 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.421620 | 0.375 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.421620 | 0.375 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.427465 | 0.369 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.427465 | 0.369 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.433251 | 0.363 |
| R-HSA-5620924 | Intraflagellar transport | 0.433251 | 0.363 |
| R-HSA-1474165 | Reproduction | 0.435471 | 0.361 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.438896 | 0.358 |
| R-HSA-9766229 | Degradation of CDH1 | 0.438979 | 0.358 |
| R-HSA-73893 | DNA Damage Bypass | 0.438979 | 0.358 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.438979 | 0.358 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 0.438979 | 0.358 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.442310 | 0.354 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.450263 | 0.347 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.450263 | 0.347 |
| R-HSA-912446 | Meiotic recombination | 0.450263 | 0.347 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.451736 | 0.345 |
| R-HSA-72187 | mRNA 3'-end processing | 0.455820 | 0.341 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.455820 | 0.341 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.455820 | 0.341 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.455820 | 0.341 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.455820 | 0.341 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.459849 | 0.337 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.461321 | 0.336 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.465884 | 0.332 |
| R-HSA-6807070 | PTEN Regulation | 0.469204 | 0.329 |
| R-HSA-72312 | rRNA processing | 0.470260 | 0.328 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.472158 | 0.326 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.472158 | 0.326 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.472158 | 0.326 |
| R-HSA-168256 | Immune System | 0.472193 | 0.326 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.472477 | 0.326 |
| R-HSA-9664407 | Parasite infection | 0.472512 | 0.326 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.472512 | 0.326 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.472512 | 0.326 |
| R-HSA-1632852 | Macroautophagy | 0.475807 | 0.323 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.475807 | 0.323 |
| R-HSA-1474244 | Extracellular matrix organization | 0.476050 | 0.322 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.477495 | 0.321 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.477495 | 0.321 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.477495 | 0.321 |
| R-HSA-72766 | Translation | 0.479795 | 0.319 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.482361 | 0.317 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.482778 | 0.316 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.482778 | 0.316 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.488008 | 0.312 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.493186 | 0.307 |
| R-HSA-191859 | snRNP Assembly | 0.493186 | 0.307 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.493186 | 0.307 |
| R-HSA-9033241 | Peroxisomal protein import | 0.493186 | 0.307 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.493186 | 0.307 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.498312 | 0.302 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.498312 | 0.302 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.498312 | 0.302 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.498312 | 0.302 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.498312 | 0.302 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.498312 | 0.302 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.498312 | 0.302 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.498312 | 0.302 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.498312 | 0.302 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.498312 | 0.302 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.503386 | 0.298 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.503386 | 0.298 |
| R-HSA-112043 | PLC beta mediated events | 0.503386 | 0.298 |
| R-HSA-211976 | Endogenous sterols | 0.503386 | 0.298 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.508067 | 0.294 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.508409 | 0.294 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.508409 | 0.294 |
| R-HSA-186797 | Signaling by PDGF | 0.508409 | 0.294 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.511222 | 0.291 |
| R-HSA-8848021 | Signaling by PTK6 | 0.513382 | 0.290 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.513382 | 0.290 |
| R-HSA-8963743 | Digestion and absorption | 0.513382 | 0.290 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.514924 | 0.288 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.517492 | 0.286 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.520607 | 0.283 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.523177 | 0.281 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.523709 | 0.281 |
| R-HSA-9612973 | Autophagy | 0.526797 | 0.278 |
| R-HSA-9679506 | SARS-CoV Infections | 0.529217 | 0.276 |
| R-HSA-162587 | HIV Life Cycle | 0.529872 | 0.276 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.529872 | 0.276 |
| R-HSA-212436 | Generic Transcription Pathway | 0.530299 | 0.275 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.532777 | 0.273 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.532777 | 0.273 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.532777 | 0.273 |
| R-HSA-112040 | G-protein mediated events | 0.532777 | 0.273 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.537505 | 0.270 |
| R-HSA-5218859 | Regulated Necrosis | 0.537505 | 0.270 |
| R-HSA-73894 | DNA Repair | 0.538028 | 0.269 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.539016 | 0.268 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.539016 | 0.268 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.546818 | 0.262 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.546818 | 0.262 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.546818 | 0.262 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.551404 | 0.259 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.551404 | 0.259 |
| R-HSA-112316 | Neuronal System | 0.553258 | 0.257 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.555944 | 0.255 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.555944 | 0.255 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.560439 | 0.251 |
| R-HSA-4086398 | Ca2+ pathway | 0.560439 | 0.251 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.560439 | 0.251 |
| R-HSA-9749641 | Aspirin ADME | 0.560439 | 0.251 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.564888 | 0.248 |
| R-HSA-5689603 | UCH proteinases | 0.573653 | 0.241 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.573653 | 0.241 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.573653 | 0.241 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.577216 | 0.239 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.580057 | 0.237 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.580057 | 0.237 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.580057 | 0.237 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.582242 | 0.235 |
| R-HSA-5619084 | ABC transporter disorders | 0.582242 | 0.235 |
| R-HSA-216083 | Integrin cell surface interactions | 0.582242 | 0.235 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.582242 | 0.235 |
| R-HSA-446728 | Cell junction organization | 0.582603 | 0.235 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.582885 | 0.234 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.591646 | 0.228 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.594805 | 0.226 |
| R-HSA-168255 | Influenza Infection | 0.596814 | 0.224 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.602971 | 0.220 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.610973 | 0.214 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.610973 | 0.214 |
| R-HSA-69275 | G2/M Transition | 0.615729 | 0.211 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.615729 | 0.211 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.618815 | 0.208 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.618815 | 0.208 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.621007 | 0.207 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.622677 | 0.206 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.626499 | 0.203 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.634030 | 0.198 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.637739 | 0.195 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.637739 | 0.195 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.641567 | 0.193 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.645044 | 0.190 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.648642 | 0.188 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.651516 | 0.186 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.652203 | 0.186 |
| R-HSA-428157 | Sphingolipid metabolism | 0.653969 | 0.184 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.655729 | 0.183 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.659219 | 0.181 |
| R-HSA-1296071 | Potassium Channels | 0.662674 | 0.179 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.666094 | 0.176 |
| R-HSA-5663205 | Infectious disease | 0.669310 | 0.174 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.669479 | 0.174 |
| R-HSA-422356 | Regulation of insulin secretion | 0.669479 | 0.174 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.672831 | 0.172 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.676148 | 0.170 |
| R-HSA-70171 | Glycolysis | 0.676148 | 0.170 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.676411 | 0.170 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.676901 | 0.169 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.679433 | 0.168 |
| R-HSA-1643685 | Disease | 0.681846 | 0.166 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.682344 | 0.166 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.682684 | 0.166 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.682684 | 0.166 |
| R-HSA-192823 | Viral mRNA Translation | 0.685902 | 0.164 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.689088 | 0.162 |
| R-HSA-9833110 | RSV-host interactions | 0.692242 | 0.160 |
| R-HSA-418990 | Adherens junctions interactions | 0.695809 | 0.158 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.701514 | 0.154 |
| R-HSA-69239 | Synthesis of DNA | 0.701514 | 0.154 |
| R-HSA-211000 | Gene Silencing by RNA | 0.701514 | 0.154 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.704542 | 0.152 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.704542 | 0.152 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.707540 | 0.150 |
| R-HSA-202403 | TCR signaling | 0.710508 | 0.148 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.713029 | 0.147 |
| R-HSA-162906 | HIV Infection | 0.715124 | 0.146 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.722082 | 0.141 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.722082 | 0.141 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.724903 | 0.140 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.730460 | 0.136 |
| R-HSA-70326 | Glucose metabolism | 0.735906 | 0.133 |
| R-HSA-5693538 | Homology Directed Repair | 0.738587 | 0.132 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.751595 | 0.124 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.754118 | 0.123 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.754396 | 0.122 |
| R-HSA-4839726 | Chromatin organization | 0.758057 | 0.120 |
| R-HSA-69206 | G1/S Transition | 0.759088 | 0.120 |
| R-HSA-194138 | Signaling by VEGF | 0.759088 | 0.120 |
| R-HSA-421270 | Cell-cell junction organization | 0.761671 | 0.118 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.766357 | 0.116 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.770503 | 0.113 |
| R-HSA-9843745 | Adipogenesis | 0.775710 | 0.110 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.778417 | 0.109 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.782391 | 0.107 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.789047 | 0.103 |
| R-HSA-163685 | Integration of energy metabolism | 0.789047 | 0.103 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.791192 | 0.102 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.793316 | 0.101 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.803614 | 0.095 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.810523 | 0.091 |
| R-HSA-9658195 | Leishmania infection | 0.810523 | 0.091 |
| R-HSA-418594 | G alpha (i) signalling events | 0.810528 | 0.091 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.811484 | 0.091 |
| R-HSA-69242 | S Phase | 0.815301 | 0.089 |
| R-HSA-166520 | Signaling by NTRKs | 0.815301 | 0.089 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.821959 | 0.085 |
| R-HSA-69306 | DNA Replication | 0.824510 | 0.084 |
| R-HSA-9609507 | Protein localization | 0.824510 | 0.084 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.826297 | 0.083 |
| R-HSA-73887 | Death Receptor Signaling | 0.826297 | 0.083 |
| R-HSA-9824446 | Viral Infection Pathways | 0.828344 | 0.082 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.830128 | 0.081 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.831456 | 0.080 |
| R-HSA-9610379 | HCMV Late Events | 0.831548 | 0.080 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.831548 | 0.080 |
| R-HSA-9711097 | Cellular response to starvation | 0.833263 | 0.079 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.843195 | 0.074 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.847939 | 0.072 |
| R-HSA-5619102 | SLC transporter disorders | 0.847939 | 0.072 |
| R-HSA-72306 | tRNA processing | 0.854042 | 0.069 |
| R-HSA-418555 | G alpha (s) signalling events | 0.855530 | 0.068 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.858459 | 0.066 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.858459 | 0.066 |
| R-HSA-983712 | Ion channel transport | 0.879868 | 0.056 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.883313 | 0.054 |
| R-HSA-168249 | Innate Immune System | 0.884449 | 0.053 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.887966 | 0.052 |
| R-HSA-9609690 | HCMV Early Events | 0.888191 | 0.051 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.895941 | 0.048 |
| R-HSA-9748784 | Drug ADME | 0.911707 | 0.040 |
| R-HSA-913531 | Interferon Signaling | 0.917418 | 0.037 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.924672 | 0.034 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.925097 | 0.034 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.928852 | 0.032 |
| R-HSA-157118 | Signaling by NOTCH | 0.929581 | 0.032 |
| R-HSA-8978868 | Fatty acid metabolism | 0.932474 | 0.030 |
| R-HSA-9609646 | HCMV Infection | 0.936467 | 0.029 |
| R-HSA-5668914 | Diseases of metabolism | 0.943008 | 0.025 |
| R-HSA-416476 | G alpha (q) signalling events | 0.944999 | 0.025 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.952390 | 0.021 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.958809 | 0.018 |
| R-HSA-1483257 | Phospholipid metabolism | 0.960050 | 0.018 |
| R-HSA-195721 | Signaling by WNT | 0.961269 | 0.017 |
| R-HSA-388396 | GPCR downstream signalling | 0.962396 | 0.017 |
| R-HSA-8957322 | Metabolism of steroids | 0.970395 | 0.013 |
| R-HSA-211859 | Biological oxidations | 0.975270 | 0.011 |
| R-HSA-372790 | Signaling by GPCR | 0.979571 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.986254 | 0.006 |
| R-HSA-500792 | GPCR ligand binding | 0.986305 | 0.006 |
| R-HSA-382551 | Transport of small molecules | 0.992156 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.992485 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 0.998394 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999974 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.837 | 0.166 | 2 | 0.842 |
CLK3 |
0.835 | 0.183 | 1 | 0.852 |
PIM1 |
0.830 | 0.206 | -3 | 0.816 |
PIM3 |
0.829 | 0.147 | -3 | 0.831 |
NDR2 |
0.828 | 0.134 | -3 | 0.836 |
DSTYK |
0.828 | 0.169 | 2 | 0.876 |
RSK2 |
0.827 | 0.156 | -3 | 0.797 |
NDR1 |
0.827 | 0.158 | -3 | 0.848 |
PKN3 |
0.826 | 0.131 | -3 | 0.824 |
LATS2 |
0.824 | 0.129 | -5 | 0.797 |
CAMK1B |
0.824 | 0.117 | -3 | 0.865 |
CAMK2G |
0.822 | 0.096 | 2 | 0.814 |
SRPK1 |
0.822 | 0.116 | -3 | 0.769 |
LATS1 |
0.821 | 0.199 | -3 | 0.829 |
PRPK |
0.820 | -0.032 | -1 | 0.720 |
FAM20C |
0.820 | 0.199 | 2 | 0.690 |
MST4 |
0.820 | 0.105 | 2 | 0.819 |
RAF1 |
0.819 | 0.044 | 1 | 0.860 |
PKN2 |
0.819 | 0.114 | -3 | 0.863 |
P70S6KB |
0.818 | 0.139 | -3 | 0.829 |
CAMK2B |
0.818 | 0.172 | 2 | 0.798 |
CDKL1 |
0.818 | 0.070 | -3 | 0.806 |
WNK1 |
0.817 | 0.087 | -2 | 0.802 |
PRKD2 |
0.817 | 0.113 | -3 | 0.816 |
SRPK2 |
0.817 | 0.115 | -3 | 0.709 |
PKACG |
0.817 | 0.124 | -2 | 0.741 |
MOS |
0.816 | 0.020 | 1 | 0.863 |
PKCD |
0.816 | 0.106 | 2 | 0.804 |
GCN2 |
0.816 | -0.054 | 2 | 0.828 |
RSK3 |
0.816 | 0.104 | -3 | 0.783 |
P90RSK |
0.815 | 0.094 | -3 | 0.785 |
NIK |
0.815 | 0.078 | -3 | 0.872 |
RSK4 |
0.815 | 0.157 | -3 | 0.761 |
CAMK2A |
0.814 | 0.137 | 2 | 0.813 |
CDKL5 |
0.814 | 0.079 | -3 | 0.801 |
PRKD1 |
0.814 | 0.058 | -3 | 0.825 |
NEK6 |
0.814 | 0.053 | -2 | 0.851 |
MTOR |
0.814 | -0.062 | 1 | 0.809 |
BMPR2 |
0.814 | -0.041 | -2 | 0.856 |
ULK2 |
0.814 | -0.044 | 2 | 0.789 |
PKACB |
0.813 | 0.146 | -2 | 0.682 |
NUAK2 |
0.813 | 0.054 | -3 | 0.856 |
IKKB |
0.813 | -0.021 | -2 | 0.686 |
CAMK2D |
0.813 | 0.064 | -3 | 0.853 |
MAPKAPK2 |
0.812 | 0.113 | -3 | 0.780 |
CAMLCK |
0.812 | 0.052 | -2 | 0.803 |
SKMLCK |
0.812 | 0.055 | -2 | 0.795 |
PRKX |
0.812 | 0.178 | -3 | 0.739 |
PDHK4 |
0.811 | -0.163 | 1 | 0.868 |
NEK7 |
0.811 | -0.004 | -3 | 0.804 |
AURC |
0.811 | 0.097 | -2 | 0.653 |
NLK |
0.811 | -0.005 | 1 | 0.855 |
TBK1 |
0.811 | -0.023 | 1 | 0.786 |
TSSK2 |
0.811 | 0.096 | -5 | 0.752 |
MAPKAPK3 |
0.811 | 0.067 | -3 | 0.818 |
SRPK3 |
0.810 | 0.089 | -3 | 0.740 |
ATR |
0.810 | -0.023 | 1 | 0.836 |
CDC7 |
0.810 | -0.085 | 1 | 0.814 |
CLK2 |
0.809 | 0.153 | -3 | 0.780 |
TGFBR2 |
0.809 | 0.030 | -2 | 0.828 |
PIM2 |
0.809 | 0.164 | -3 | 0.787 |
AMPKA1 |
0.809 | 0.050 | -3 | 0.868 |
SGK3 |
0.808 | 0.147 | -3 | 0.804 |
PAK1 |
0.807 | 0.071 | -2 | 0.723 |
PDHK1 |
0.807 | -0.129 | 1 | 0.870 |
PKCB |
0.807 | 0.089 | 2 | 0.765 |
PKCG |
0.807 | 0.077 | 2 | 0.762 |
HUNK |
0.807 | -0.045 | 2 | 0.792 |
CLK4 |
0.807 | 0.097 | -3 | 0.799 |
CLK1 |
0.807 | 0.111 | -3 | 0.791 |
IKKE |
0.806 | -0.038 | 1 | 0.785 |
PLK1 |
0.806 | 0.108 | -2 | 0.820 |
GRK6 |
0.806 | 0.053 | 1 | 0.811 |
DAPK2 |
0.806 | 0.003 | -3 | 0.859 |
TSSK1 |
0.806 | 0.061 | -3 | 0.873 |
ERK5 |
0.806 | 0.007 | 1 | 0.854 |
CAMK4 |
0.805 | 0.040 | -3 | 0.849 |
MSK2 |
0.805 | 0.050 | -3 | 0.767 |
ICK |
0.805 | 0.031 | -3 | 0.830 |
MLK1 |
0.805 | -0.057 | 2 | 0.835 |
RIPK3 |
0.805 | -0.067 | 3 | 0.648 |
WNK3 |
0.804 | -0.082 | 1 | 0.842 |
MSK1 |
0.804 | 0.079 | -3 | 0.781 |
PRKD3 |
0.804 | 0.078 | -3 | 0.786 |
BCKDK |
0.804 | -0.073 | -1 | 0.673 |
AKT2 |
0.804 | 0.111 | -3 | 0.740 |
AMPKA2 |
0.804 | 0.047 | -3 | 0.853 |
ATM |
0.804 | 0.038 | 1 | 0.767 |
ULK1 |
0.803 | -0.076 | -3 | 0.772 |
MARK4 |
0.803 | -0.043 | 4 | 0.689 |
PKCH |
0.803 | 0.067 | 2 | 0.759 |
PKCA |
0.803 | 0.064 | 2 | 0.754 |
CHAK2 |
0.802 | -0.049 | -1 | 0.720 |
BMPR1B |
0.802 | 0.115 | 1 | 0.743 |
MNK2 |
0.802 | 0.045 | -2 | 0.759 |
MNK1 |
0.802 | 0.069 | -2 | 0.774 |
GRK1 |
0.802 | 0.029 | -2 | 0.698 |
AURB |
0.802 | 0.064 | -2 | 0.647 |
PKG2 |
0.801 | 0.105 | -2 | 0.695 |
IRE2 |
0.801 | 0.027 | 2 | 0.761 |
NEK9 |
0.801 | -0.064 | 2 | 0.826 |
KIS |
0.801 | 0.044 | 1 | 0.733 |
ALK4 |
0.801 | 0.077 | -2 | 0.828 |
TGFBR1 |
0.801 | 0.109 | -2 | 0.809 |
IKKA |
0.801 | 0.001 | -2 | 0.674 |
PAK3 |
0.801 | 0.021 | -2 | 0.724 |
GRK5 |
0.801 | -0.121 | -3 | 0.794 |
ANKRD3 |
0.800 | -0.058 | 1 | 0.871 |
PKACA |
0.800 | 0.126 | -2 | 0.651 |
ALK2 |
0.799 | 0.130 | -2 | 0.808 |
PKR |
0.799 | 0.017 | 1 | 0.858 |
HIPK4 |
0.799 | 0.000 | 1 | 0.809 |
NIM1 |
0.799 | -0.033 | 3 | 0.659 |
DLK |
0.798 | -0.104 | 1 | 0.819 |
AURA |
0.798 | 0.055 | -2 | 0.613 |
GRK7 |
0.798 | 0.101 | 1 | 0.747 |
DNAPK |
0.798 | 0.074 | 1 | 0.746 |
CHK1 |
0.798 | 0.035 | -3 | 0.837 |
DCAMKL1 |
0.798 | 0.087 | -3 | 0.824 |
NEK2 |
0.797 | 0.018 | 2 | 0.808 |
IRE1 |
0.797 | -0.054 | 1 | 0.808 |
MELK |
0.797 | 0.028 | -3 | 0.844 |
MYLK4 |
0.797 | 0.041 | -2 | 0.730 |
MASTL |
0.796 | -0.208 | -2 | 0.746 |
PHKG1 |
0.796 | 0.019 | -3 | 0.850 |
PLK3 |
0.796 | 0.057 | 2 | 0.759 |
NUAK1 |
0.796 | -0.005 | -3 | 0.829 |
MEK1 |
0.795 | -0.055 | 2 | 0.859 |
PAK6 |
0.795 | 0.055 | -2 | 0.643 |
MLK2 |
0.794 | -0.112 | 2 | 0.828 |
PKCZ |
0.793 | -0.010 | 2 | 0.786 |
AKT1 |
0.793 | 0.097 | -3 | 0.764 |
ACVR2A |
0.793 | 0.061 | -2 | 0.829 |
CK2A2 |
0.793 | 0.233 | 1 | 0.672 |
PAK2 |
0.793 | 0.004 | -2 | 0.702 |
GRK4 |
0.793 | -0.087 | -2 | 0.781 |
CAMK1G |
0.792 | 0.033 | -3 | 0.803 |
BRSK1 |
0.792 | 0.012 | -3 | 0.823 |
MLK3 |
0.792 | -0.035 | 2 | 0.780 |
BRAF |
0.792 | 0.064 | -4 | 0.773 |
TTBK2 |
0.792 | -0.118 | 2 | 0.700 |
ACVR2B |
0.791 | 0.052 | -2 | 0.832 |
SGK1 |
0.791 | 0.141 | -3 | 0.671 |
YSK4 |
0.791 | -0.058 | 1 | 0.795 |
CAMK1D |
0.791 | 0.092 | -3 | 0.750 |
QIK |
0.791 | -0.067 | -3 | 0.845 |
CDK5 |
0.791 | 0.033 | 1 | 0.727 |
DYRK2 |
0.791 | 0.027 | 1 | 0.718 |
DCAMKL2 |
0.790 | 0.049 | -3 | 0.845 |
MLK4 |
0.790 | -0.030 | 2 | 0.779 |
PKCT |
0.790 | 0.049 | 2 | 0.757 |
P70S6K |
0.790 | 0.076 | -3 | 0.759 |
TLK1 |
0.790 | 0.037 | -2 | 0.834 |
SIK |
0.790 | -0.011 | -3 | 0.804 |
CDK18 |
0.790 | 0.043 | 1 | 0.640 |
RIPK1 |
0.790 | -0.194 | 1 | 0.815 |
SMMLCK |
0.789 | 0.040 | -3 | 0.836 |
PHKG2 |
0.789 | 0.057 | -3 | 0.843 |
HRI |
0.789 | -0.041 | -2 | 0.850 |
JNK2 |
0.789 | 0.064 | 1 | 0.652 |
BMPR1A |
0.788 | 0.100 | 1 | 0.719 |
TLK2 |
0.788 | -0.031 | 1 | 0.815 |
QSK |
0.788 | -0.051 | 4 | 0.658 |
CDK8 |
0.788 | -0.019 | 1 | 0.697 |
PASK |
0.788 | 0.049 | -3 | 0.830 |
DRAK1 |
0.787 | -0.025 | 1 | 0.724 |
PKCE |
0.787 | 0.084 | 2 | 0.748 |
SSTK |
0.787 | 0.058 | 4 | 0.649 |
WNK4 |
0.787 | -0.037 | -2 | 0.786 |
JNK3 |
0.787 | 0.040 | 1 | 0.687 |
PLK4 |
0.786 | -0.035 | 2 | 0.637 |
CDK1 |
0.786 | 0.024 | 1 | 0.652 |
MST3 |
0.786 | 0.039 | 2 | 0.817 |
HIPK1 |
0.786 | 0.053 | 1 | 0.739 |
MEKK3 |
0.785 | -0.060 | 1 | 0.808 |
CDK2 |
0.785 | 0.002 | 1 | 0.727 |
VRK2 |
0.785 | -0.256 | 1 | 0.876 |
PKCI |
0.785 | 0.038 | 2 | 0.771 |
AKT3 |
0.785 | 0.108 | -3 | 0.684 |
BRSK2 |
0.784 | -0.050 | -3 | 0.849 |
PERK |
0.784 | -0.067 | -2 | 0.828 |
P38A |
0.784 | 0.011 | 1 | 0.751 |
CHAK1 |
0.784 | -0.126 | 2 | 0.739 |
ZAK |
0.784 | -0.048 | 1 | 0.783 |
CDK16 |
0.784 | 0.077 | 1 | 0.601 |
MARK2 |
0.784 | -0.059 | 4 | 0.579 |
MRCKA |
0.784 | 0.136 | -3 | 0.806 |
CDK7 |
0.784 | -0.019 | 1 | 0.710 |
DAPK3 |
0.784 | 0.073 | -3 | 0.829 |
MRCKB |
0.783 | 0.125 | -3 | 0.794 |
MARK3 |
0.783 | -0.053 | 4 | 0.609 |
MEKK2 |
0.783 | -0.034 | 2 | 0.824 |
MAPKAPK5 |
0.783 | -0.053 | -3 | 0.757 |
SNRK |
0.782 | -0.109 | 2 | 0.673 |
NEK5 |
0.782 | -0.052 | 1 | 0.856 |
MEKK1 |
0.782 | -0.095 | 1 | 0.832 |
ROCK2 |
0.782 | 0.139 | -3 | 0.823 |
DYRK1A |
0.782 | 0.028 | 1 | 0.767 |
MEK5 |
0.781 | -0.160 | 2 | 0.830 |
CDK14 |
0.781 | 0.044 | 1 | 0.685 |
CDK10 |
0.781 | 0.071 | 1 | 0.670 |
PKN1 |
0.781 | 0.063 | -3 | 0.779 |
CDK19 |
0.781 | -0.021 | 1 | 0.660 |
TAO3 |
0.780 | -0.021 | 1 | 0.811 |
GAK |
0.780 | 0.079 | 1 | 0.881 |
DMPK1 |
0.780 | 0.158 | -3 | 0.814 |
P38G |
0.780 | 0.034 | 1 | 0.573 |
PINK1 |
0.780 | -0.098 | 1 | 0.862 |
MARK1 |
0.780 | -0.068 | 4 | 0.637 |
CDK3 |
0.780 | 0.049 | 1 | 0.601 |
CK2A1 |
0.779 | 0.183 | 1 | 0.646 |
HIPK2 |
0.779 | 0.040 | 1 | 0.635 |
P38B |
0.779 | 0.019 | 1 | 0.679 |
IRAK4 |
0.779 | -0.081 | 1 | 0.820 |
TNIK |
0.779 | 0.067 | 3 | 0.727 |
CDK17 |
0.778 | 0.017 | 1 | 0.580 |
CDK13 |
0.778 | -0.030 | 1 | 0.683 |
GRK2 |
0.778 | -0.068 | -2 | 0.684 |
DYRK1B |
0.778 | 0.040 | 1 | 0.680 |
ERK2 |
0.778 | -0.015 | 1 | 0.706 |
CDK9 |
0.777 | -0.022 | 1 | 0.691 |
DYRK4 |
0.777 | 0.042 | 1 | 0.647 |
SBK |
0.777 | 0.090 | -3 | 0.647 |
SMG1 |
0.777 | -0.121 | 1 | 0.792 |
HIPK3 |
0.777 | 0.014 | 1 | 0.749 |
DAPK1 |
0.776 | 0.046 | -3 | 0.811 |
TAO2 |
0.776 | -0.028 | 2 | 0.827 |
DYRK3 |
0.776 | 0.034 | 1 | 0.737 |
ERK1 |
0.775 | -0.005 | 1 | 0.672 |
CHK2 |
0.775 | 0.047 | -3 | 0.705 |
GSK3A |
0.775 | -0.009 | 4 | 0.387 |
NEK8 |
0.774 | -0.076 | 2 | 0.807 |
EEF2K |
0.774 | 0.011 | 3 | 0.706 |
PRP4 |
0.774 | -0.030 | -3 | 0.698 |
CAMKK1 |
0.773 | -0.092 | -2 | 0.675 |
ERK7 |
0.773 | 0.056 | 2 | 0.607 |
CAMK1A |
0.773 | 0.051 | -3 | 0.726 |
GSK3B |
0.772 | -0.052 | 4 | 0.373 |
PAK5 |
0.772 | 0.001 | -2 | 0.582 |
MST2 |
0.772 | -0.019 | 1 | 0.832 |
CDK12 |
0.772 | -0.028 | 1 | 0.656 |
LOK |
0.771 | 0.019 | -2 | 0.742 |
ROCK1 |
0.771 | 0.116 | -3 | 0.807 |
GCK |
0.771 | -0.021 | 1 | 0.831 |
HGK |
0.771 | -0.022 | 3 | 0.715 |
MINK |
0.770 | -0.018 | 1 | 0.834 |
CK1E |
0.770 | -0.061 | -3 | 0.495 |
NEK11 |
0.769 | -0.156 | 1 | 0.814 |
MEKK6 |
0.769 | -0.066 | 1 | 0.818 |
P38D |
0.769 | 0.030 | 1 | 0.607 |
NEK4 |
0.769 | -0.076 | 1 | 0.831 |
PDK1 |
0.768 | -0.083 | 1 | 0.822 |
PLK2 |
0.767 | 0.006 | -3 | 0.682 |
MST1 |
0.767 | -0.017 | 1 | 0.823 |
LKB1 |
0.767 | -0.096 | -3 | 0.807 |
MPSK1 |
0.767 | -0.067 | 1 | 0.837 |
HPK1 |
0.767 | -0.002 | 1 | 0.820 |
PAK4 |
0.767 | -0.008 | -2 | 0.589 |
CAMKK2 |
0.767 | -0.120 | -2 | 0.676 |
CRIK |
0.766 | 0.106 | -3 | 0.753 |
KHS1 |
0.766 | 0.027 | 1 | 0.829 |
KHS2 |
0.766 | 0.047 | 1 | 0.838 |
IRAK1 |
0.766 | -0.214 | -1 | 0.586 |
TAK1 |
0.765 | -0.071 | 1 | 0.852 |
NEK1 |
0.764 | -0.057 | 1 | 0.828 |
PKG1 |
0.764 | 0.056 | -2 | 0.650 |
LRRK2 |
0.764 | -0.120 | 2 | 0.826 |
PBK |
0.764 | 0.053 | 1 | 0.836 |
GRK3 |
0.764 | -0.061 | -2 | 0.643 |
MAK |
0.764 | 0.047 | -2 | 0.626 |
CDK6 |
0.763 | 0.016 | 1 | 0.671 |
SLK |
0.762 | -0.049 | -2 | 0.682 |
MOK |
0.762 | 0.048 | 1 | 0.759 |
YSK1 |
0.762 | -0.024 | 2 | 0.801 |
TTBK1 |
0.761 | -0.166 | 2 | 0.610 |
CK1A2 |
0.761 | -0.059 | -3 | 0.458 |
CK1D |
0.761 | -0.065 | -3 | 0.453 |
TTK |
0.761 | 0.054 | -2 | 0.834 |
JNK1 |
0.760 | 0.002 | 1 | 0.634 |
BUB1 |
0.760 | 0.019 | -5 | 0.694 |
CDK4 |
0.760 | 0.009 | 1 | 0.644 |
MAP3K15 |
0.760 | -0.142 | 1 | 0.779 |
CK1G1 |
0.760 | -0.080 | -3 | 0.483 |
OSR1 |
0.758 | 0.014 | 2 | 0.822 |
STK33 |
0.756 | -0.134 | 2 | 0.618 |
MEK2 |
0.754 | -0.171 | 2 | 0.818 |
NEK3 |
0.753 | -0.117 | 1 | 0.791 |
RIPK2 |
0.752 | -0.207 | 1 | 0.753 |
VRK1 |
0.752 | -0.232 | 2 | 0.794 |
HASPIN |
0.751 | -0.022 | -1 | 0.580 |
BIKE |
0.749 | 0.056 | 1 | 0.786 |
MYO3B |
0.748 | -0.038 | 2 | 0.810 |
PDHK3_TYR |
0.748 | 0.175 | 4 | 0.804 |
MYO3A |
0.746 | -0.040 | 1 | 0.812 |
TAO1 |
0.744 | -0.068 | 1 | 0.753 |
ASK1 |
0.742 | -0.126 | 1 | 0.762 |
ALPHAK3 |
0.741 | -0.049 | -1 | 0.699 |
MAP2K6_TYR |
0.739 | 0.077 | -1 | 0.779 |
MAP2K4_TYR |
0.738 | 0.030 | -1 | 0.761 |
TESK1_TYR |
0.738 | 0.002 | 3 | 0.749 |
EPHA6 |
0.738 | 0.099 | -1 | 0.783 |
PINK1_TYR |
0.737 | 0.017 | 1 | 0.838 |
BMPR2_TYR |
0.737 | 0.034 | -1 | 0.783 |
PDHK4_TYR |
0.736 | 0.019 | 2 | 0.843 |
PDHK1_TYR |
0.736 | 0.063 | -1 | 0.802 |
LIMK2_TYR |
0.735 | 0.035 | -3 | 0.873 |
MAP2K7_TYR |
0.735 | -0.076 | 2 | 0.833 |
PKMYT1_TYR |
0.735 | -0.065 | 3 | 0.725 |
AAK1 |
0.734 | 0.083 | 1 | 0.697 |
STLK3 |
0.734 | -0.088 | 1 | 0.757 |
YANK3 |
0.733 | -0.090 | 2 | 0.390 |
RET |
0.730 | -0.009 | 1 | 0.819 |
INSRR |
0.727 | 0.044 | 3 | 0.629 |
LIMK1_TYR |
0.727 | -0.105 | 2 | 0.827 |
DDR1 |
0.726 | -0.048 | 4 | 0.714 |
EPHB4 |
0.725 | -0.007 | -1 | 0.741 |
TYK2 |
0.724 | -0.088 | 1 | 0.826 |
JAK3 |
0.724 | 0.006 | 1 | 0.783 |
MST1R |
0.723 | -0.098 | 3 | 0.690 |
ROS1 |
0.723 | -0.074 | 3 | 0.646 |
FGR |
0.722 | -0.023 | 1 | 0.865 |
ABL2 |
0.722 | -0.010 | -1 | 0.696 |
FGFR2 |
0.720 | -0.021 | 3 | 0.674 |
JAK2 |
0.720 | -0.106 | 1 | 0.822 |
KDR |
0.719 | -0.011 | 3 | 0.645 |
CSF1R |
0.719 | -0.092 | 3 | 0.672 |
YES1 |
0.719 | -0.049 | -1 | 0.692 |
TYRO3 |
0.718 | -0.163 | 3 | 0.664 |
EPHA4 |
0.718 | -0.018 | 2 | 0.747 |
TNNI3K_TYR |
0.718 | -0.006 | 1 | 0.835 |
CK1A |
0.717 | -0.100 | -3 | 0.364 |
FER |
0.716 | -0.098 | 1 | 0.856 |
TNK2 |
0.716 | -0.076 | 3 | 0.649 |
FLT3 |
0.716 | -0.064 | 3 | 0.659 |
BLK |
0.716 | 0.031 | -1 | 0.723 |
FLT1 |
0.716 | 0.021 | -1 | 0.800 |
ABL1 |
0.715 | -0.052 | -1 | 0.677 |
EPHB3 |
0.715 | -0.033 | -1 | 0.722 |
PDGFRB |
0.714 | -0.108 | 3 | 0.670 |
LCK |
0.714 | -0.026 | -1 | 0.696 |
TXK |
0.713 | -0.038 | 1 | 0.801 |
NEK10_TYR |
0.713 | -0.067 | 1 | 0.714 |
DDR2 |
0.712 | 0.002 | 3 | 0.621 |
EPHB1 |
0.712 | -0.070 | 1 | 0.820 |
EPHB2 |
0.712 | -0.032 | -1 | 0.725 |
HCK |
0.712 | -0.093 | -1 | 0.686 |
KIT |
0.712 | -0.105 | 3 | 0.669 |
TNK1 |
0.711 | -0.103 | 3 | 0.652 |
FGFR1 |
0.711 | -0.095 | 3 | 0.649 |
FLT4 |
0.709 | -0.060 | 3 | 0.640 |
SRMS |
0.708 | -0.121 | 1 | 0.823 |
FGFR3 |
0.708 | -0.050 | 3 | 0.655 |
ITK |
0.708 | -0.120 | -1 | 0.643 |
TEK |
0.708 | -0.141 | 3 | 0.617 |
CK1G3 |
0.707 | -0.086 | -3 | 0.320 |
AXL |
0.707 | -0.132 | 3 | 0.662 |
JAK1 |
0.706 | -0.083 | 1 | 0.769 |
EPHA7 |
0.706 | -0.058 | 2 | 0.753 |
MET |
0.706 | -0.106 | 3 | 0.662 |
INSR |
0.706 | -0.089 | 3 | 0.621 |
EPHA3 |
0.706 | -0.085 | 2 | 0.721 |
LTK |
0.706 | -0.107 | 3 | 0.620 |
EPHA5 |
0.704 | -0.018 | 2 | 0.741 |
PDGFRA |
0.704 | -0.184 | 3 | 0.663 |
NTRK1 |
0.704 | -0.142 | -1 | 0.706 |
MERTK |
0.703 | -0.133 | 3 | 0.660 |
FYN |
0.703 | -0.038 | -1 | 0.675 |
TEC |
0.703 | -0.118 | -1 | 0.570 |
ALK |
0.702 | -0.144 | 3 | 0.590 |
YANK2 |
0.702 | -0.111 | 2 | 0.425 |
ERBB2 |
0.702 | -0.116 | 1 | 0.757 |
BMX |
0.701 | -0.111 | -1 | 0.576 |
WEE1_TYR |
0.701 | -0.144 | -1 | 0.580 |
EPHA1 |
0.701 | -0.127 | 3 | 0.651 |
PTK2 |
0.700 | 0.007 | -1 | 0.749 |
MATK |
0.699 | -0.101 | -1 | 0.651 |
FRK |
0.699 | -0.098 | -1 | 0.728 |
EPHA8 |
0.699 | -0.056 | -1 | 0.732 |
NTRK2 |
0.698 | -0.168 | 3 | 0.629 |
EGFR |
0.698 | -0.035 | 1 | 0.654 |
NTRK3 |
0.698 | -0.124 | -1 | 0.667 |
LYN |
0.696 | -0.119 | 3 | 0.606 |
BTK |
0.696 | -0.243 | -1 | 0.584 |
FGFR4 |
0.694 | -0.065 | -1 | 0.693 |
IGF1R |
0.694 | -0.074 | 3 | 0.564 |
PTK6 |
0.693 | -0.241 | -1 | 0.569 |
CSK |
0.693 | -0.120 | 2 | 0.754 |
CK1G2 |
0.692 | -0.079 | -3 | 0.408 |
SYK |
0.692 | -0.010 | -1 | 0.749 |
PTK2B |
0.691 | -0.132 | -1 | 0.602 |
SRC |
0.690 | -0.116 | -1 | 0.667 |
EPHA2 |
0.689 | -0.060 | -1 | 0.712 |
ERBB4 |
0.686 | -0.045 | 1 | 0.661 |
MUSK |
0.681 | -0.142 | 1 | 0.655 |
ZAP70 |
0.664 | -0.093 | -1 | 0.638 |
FES |
0.658 | -0.223 | -1 | 0.545 |