Motif 729 (n=165)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B0I1T2 | MYO1G | S527 | ochoa | Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}. |
| O00338 | SULT1C2 | S252 | ochoa | Sulfotransferase 1C2 (ST1C2) (EC 2.8.2.1) (Sulfotransferase 1C1) (SULT1C#1) (humSULTC2) | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds (PubMed:10481272, PubMed:10783263, PubMed:9852044). Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:10481272, PubMed:9852044). Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration (By similarity). Catalyzes the sulfation of the carcinogenic N-hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044). {ECO:0000250|UniProtKB:Q9WUW8, ECO:0000269|PubMed:10481272, ECO:0000269|PubMed:10783263, ECO:0000269|PubMed:9852044}. |
| O00472 | ELL2 | S604 | ochoa | RNA polymerase II elongation factor ELL2 | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}. |
| O14686 | KMT2D | S1671 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15213 | WDR46 | S41 | ochoa | WD repeat-containing protein 46 (WD repeat-containing protein BING4) | Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus (PubMed:23848194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:34516797}. |
| O43432 | EIF4G3 | S487 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43768 | ENSA | S67 | ochoa|psp | Alpha-endosulfine (ARPP-19e) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269|PubMed:9653196}. |
| O43829 | ZBTB14 | S393 | ochoa | Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) | Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. {ECO:0000269|PubMed:17714511}. |
| O60841 | EIF5B | S66 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75152 | ZC3H11A | S533 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75533 | SF3B1 | S377 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O94885 | SASH1 | S387 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95235 | KIF20A | S244 | psp | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95235 | KIF20A | S825 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| P06748 | NPM1 | S222 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07900 | HSP90AA1 | S505 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P07949 | RET | S909 | psp | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
| P08238 | HSP90AB1 | S497 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P08567 | PLEK | S57 | ochoa | Pleckstrin (Platelet 47 kDa protein) (p47) | Major protein kinase C substrate of platelets. |
| P10809 | HSPD1 | S256 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11055 | MYH3 | S1777 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11171 | EPB41 | S191 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12882 | MYH1 | S1780 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1776 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1778 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1779 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14317 | HCLS1 | S134 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P16435 | POR | S67 | ochoa | NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) | This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. {ECO:0000255|HAMAP-Rule:MF_03212}. |
| P16949 | STMN1 | S63 | ochoa|psp | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P19174 | PLCG1 | S451 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P20042 | EIF2S2 | S39 | ochoa | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| P20810 | CAST | S379 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P23193 | TCEA1 | S110 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P29084 | GTF2E2 | S58 | ochoa | Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2) | Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. {ECO:0000269|PubMed:1956398, ECO:0000269|PubMed:1956404}. |
| P30419 | NMT1 | S100 | ochoa | Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-) | Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017, PubMed:32111831). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017). {ECO:0000269|PubMed:22865860, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:32111831, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:34999170, ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}. |
| P35222 | CTNNB1 | S374 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35240 | NF2 | S572 | ochoa | Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) | Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}. |
| P35579 | MYH9 | S375 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1808 | ochoa|psp | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S209 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P40926 | MDH2 | S289 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P41145 | OPRK1 | S358 | psp | Kappa-type opioid receptor (K-OR-1) (KOR-1) | G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}. |
| P46013 | MKI67 | S1721 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46100 | ATRX | S316 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S1245 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46940 | IQGAP1 | S1097 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P49790 | NUP153 | S1113 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P50402 | EMD | S98 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P51659 | HSD17B4 | S294 | ochoa | Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| P52735 | VAV2 | S583 | ochoa | Guanine nucleotide exchange factor VAV2 (VAV-2) | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}. |
| P54920 | NAPA | S160 | ochoa | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}. |
| P55854 | SUMO3 | S27 | ochoa | Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A) | Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678}. |
| P56211 | ARPP19 | S62 | ochoa|psp | cAMP-regulated phosphoprotein 19 (ARPP-19) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (PubMed:38123684). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (PubMed:38123684). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (PubMed:21164014). May indirectly enhance GAP-43 expression (By similarity). {ECO:0000250|UniProtKB:Q712U5, ECO:0000269|PubMed:21164014, ECO:0000269|PubMed:38123684}. |
| P60484 | PTEN | S362 | psp | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) | Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}. |
| P80192 | MAP3K9 | S533 | ochoa | Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269|PubMed:11416147, ECO:0000269|PubMed:15610029}. |
| P84098 | RPL19 | S164 | ochoa | Large ribosomal subunit protein eL19 (60S ribosomal protein L19) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q00839 | HNRNPU | S585 | ochoa | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q02952 | AKAP12 | S651 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q05397 | PTK2 | S580 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q05682 | CALD1 | S660 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q12789 | GTF3C1 | S1253 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q13153 | PAK1 | S155 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13416 | ORC2 | S188 | psp | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13573 | SNW1 | S190 | ochoa | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| Q13601 | KRR1 | S31 | ochoa | KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q13769 | THOC5 | S28 | ochoa | THO complex subunit 5 (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability (PubMed:18974867). Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (PubMed:23685434). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23685434, ECO:0000269|PubMed:33191911}.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. {ECO:0000250|UniProtKB:Q8BKT7}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q14151 | SAFB2 | S245 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14244 | MAP7 | S293 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14247 | CTTN | S117 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | S172 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | Y228 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | Y265 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14315 | FLNC | S2042 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14515 | SPARCL1 | S90 | ochoa | SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) | None |
| Q14653 | IRF3 | S97 | psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14680 | MELK | S343 | psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q14966 | ZNF638 | S641 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15424 | SAFB | S246 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q4LE39 | ARID4B | S757 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q52LW3 | ARHGAP29 | S929 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53FP2 | TMEM35A | S61 | ochoa | Novel acetylcholine receptor chaperone | Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (PubMed:32676916). {ECO:0000250|UniProtKB:Q9D328, ECO:0000269|PubMed:26875622, ECO:0000269|PubMed:27789755, ECO:0000269|PubMed:28445721, ECO:0000269|PubMed:32204458, ECO:0000269|PubMed:32676916, ECO:0000269|PubMed:32783947}. |
| Q53GQ0 | HSD17B12 | S92 | ochoa | Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1) | Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16166196}. |
| Q58FF7 | HSP90AB3P | S370 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5JTC6 | AMER1 | S47 | ochoa | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q641Q2 | WASHC2A | S925 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6PL18 | ATAD2 | S969 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6UB99 | ANKRD11 | S614 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q7L9B9 | EEPD1 | S110 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z5K2 | WAPL | S498 | psp | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z6E9 | RBBP6 | S136 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6M3 | MILR1 | S41 | ochoa | Allergin-1 (Allergy inhibitory receptor 1) (Mast cell antigen 32) (MCA-32) (Mast cell immunoglobulin-like receptor 1) | Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity). {ECO:0000250}. |
| Q86W92 | PPFIBP1 | S936 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8IW50 | FAM219A | S72 | ochoa | Protein FAM219A | None |
| Q8N5U6 | RNF10 | S110 | ochoa | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). {ECO:0000250|UniProtKB:Q5XI59, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}. |
| Q8N9T8 | KRI1 | S309 | ochoa | Protein KRI1 homolog | None |
| Q8TEK3 | DOT1L | S1083 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8WUM9 | SLC20A1 | S476 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
| Q8WYP5 | AHCTF1 | S1925 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92598 | HSPH1 | S88 | ochoa | Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}. |
| Q92888 | ARHGEF1 | S267 | ochoa | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q93045 | STMN2 | S97 | ochoa|psp | Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}. |
| Q96C57 | CUSTOS | S214 | ochoa | Protein CUSTOS | Plays a role in the regulation of Wnt signaling pathway during early development. {ECO:0000250|UniProtKB:A9C3N6}. |
| Q96JM3 | CHAMP1 | S121 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96K76 | USP47 | S1017 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96L73 | NSD1 | S1269 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96ME7 | ZNF512 | S319 | ochoa | Zinc finger protein 512 | May be involved in transcriptional regulation. |
| Q96Q89 | KIF20B | S442 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96RL1 | UIMC1 | S26 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96RS0 | TGS1 | S443 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q96RS0 | TGS1 | S577 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q99708 | RBBP8 | S311 | ochoa | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q99741 | CDC6 | S134 | ochoa | Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) | Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
| Q9BY89 | KIAA1671 | S1271 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYP7 | WNK3 | S62 | ochoa | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
| Q9C0C9 | UBE2O | S839 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9C0G0 | ZNF407 | S952 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9H115 | NAPB | S160 | ochoa | Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. {ECO:0000250|UniProtKB:P28663}. |
| Q9H1E3 | NUCKS1 | S221 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H2G2 | SLK | S372 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H410 | DSN1 | S39 | ochoa | Kinetochore-associated protein DSN1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. |
| Q9H501 | ESF1 | S134 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H501 | ESF1 | S190 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H501 | ESF1 | S663 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H583 | HEATR1 | S1190 | ochoa | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:38225354}. |
| Q9H6S1 | AZI2 | S83 | ochoa | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223). {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}. |
| Q9HB21 | PLEKHA1 | S129 | ochoa | Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}. |
| Q9NQW6 | ANLN | S502 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NQW6 | ANLN | S536 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NUM4 | TMEM106B | S23 | ochoa | Transmembrane protein 106B | In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q6AYA5, ECO:0000250|UniProtKB:Q80X71, ECO:0000269|PubMed:25066864}.; FUNCTION: (Microbial infection) Plays a role in human coronavirus SARS-CoV-2 infection, but not in common cold coronaviruses HCoV-229E and HCoV-OC43 infections. Involved in ACE2-independent SARS-CoV-2 cell entry. Required for post-endocytic stage of virus entry, facilitates spike-mediated membrane fusion. Virus attachment and endocytosis can also be mediated by other cell surface receptors. {ECO:0000269|PubMed:33333024, ECO:0000269|PubMed:33686287, ECO:0000269|PubMed:37421949}. |
| Q9NYF8 | BCLAF1 | S512 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZ63 | C9orf78 | S156 | ochoa | Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) | Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}. |
| Q9P225 | DNAH2 | S340 | ochoa | Dynein axonemal heavy chain 2 (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3) | As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583). Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583). {ECO:0000269|PubMed:30811583}. |
| Q9P2B7 | CFAP97 | S329 | ochoa | Cilia- and flagella-associated protein 97 | None |
| Q9UBW7 | ZMYM2 | S1064 | psp | Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) | Involved in the negative regulation of transcription. {ECO:0000269|PubMed:32891193}. |
| Q9UGU0 | TCF20 | S513 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UHA3 | RSL24D1 | S68 | ochoa | Probable ribosome biogenesis protein RLP24 (Ribosomal L24 domain-containing protein 1) (Ribosomal protein L24-like) | Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity). {ECO:0000250|UniProtKB:Q07915}. |
| Q9UHD8 | SEPTIN9 | S23 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UKX2 | MYH2 | S1782 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S1780 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UKY7 | CDV3 | S96 | ochoa | Protein CDV3 homolog | None |
| Q9UPN9 | TRIM33 | S789 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9Y210 | TRPC6 | S847 | ochoa | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y2W1 | THRAP3 | S339 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y5K8 | ATP6V1D | S118 | ochoa | V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (PubMed:21844891). {ECO:0000250|UniProtKB:P39942, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:33065002}. |
| Q9Y623 | MYH4 | S1780 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6K1 | DNMT3A | S236 | ochoa | DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}. |
| Q12874 | SF3A3 | S483 | Sugiyama | Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:8022796}. |
| O14920 | IKBKB | S507 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| P02786 | TFRC | S620 | Sugiyama | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity). {ECO:0000250|UniProtKB:Q62351, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.; FUNCTION: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762, ECO:0000269|PubMed:36779763}.; FUNCTION: (Microbial infection) Acts as a host entry factor for SARS-CoV, MERS-CoV and SARS-CoV-2 viruses that hijack the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762}. |
| P31948 | STIP1 | S28 | Sugiyama | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P33176 | KIF5B | S532 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| Q01082 | SPTBN1 | S1414 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| P14625 | HSP90B1 | S552 | Sugiyama | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| Q8NBS9 | TXNDC5 | S292 | Sugiyama | Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46) | Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds. {ECO:0000250|UniProtKB:Q91W90}. |
| Q9UNZ2 | NSFL1C | S205 | Sugiyama | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| P11168 | SLC2A2 | S503 | ELM|iPTMNet|EPSD | Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2) | Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). {ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:23396969, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:3399500, ECO:0000269|PubMed:8027028, ECO:0000269|PubMed:8457197}. |
| Q02880 | TOP2B | S1132 | SIGNOR | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| P83881 | RPL36A | S79 | Sugiyama | Large ribosomal subunit protein eL42 (60S ribosomal protein L36a) (60S ribosomal protein L44) (Cell growth-inhibiting gene 15 protein) (Cell migration-inducing gene 6 protein) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q969Q0 | RPL36AL | S79 | Sugiyama | Ribosomal protein eL42-like (60S ribosomal protein L36a-like) (Large ribosomal subunit protein eL42-like) | None |
| Q9Y3B8 | REXO2 | Y210 | Sugiyama | Oligoribonuclease, mitochondrial (EC 3.1.15.-) (RNA exonuclease 2 homolog) (Small fragment nuclease) | 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:23741365, PubMed:30926754, PubMed:31588022, PubMed:32365187). Binds and degrades longer oligonucleotides with a lower affinity (PubMed:30926754, PubMed:31588022, PubMed:32365187). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:30926754, PubMed:31588022, PubMed:32365187). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:Q9D8S4, ECO:0000269|PubMed:23741365, ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022, ECO:0000269|PubMed:32365187}.; FUNCTION: [Isoform 3]: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. {ECO:0000269|PubMed:10851236, ECO:0000269|PubMed:16682444}. |
| Q7Z4S6 | KIF21A | S708 | Sugiyama | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q04721 | NOTCH2 | S1621 | Sugiyama | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q9H1R3 | MYLK2 | S225 | Sugiyama | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
| P14598 | NCF1 | S288 | SIGNOR|EPSD|PSP | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
| P00492 | HPRT1 | S123 | Sugiyama | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) | Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.000099 | 4.005 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.000088 | 4.054 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.000136 | 3.866 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.000165 | 3.782 |
| R-HSA-194138 | Signaling by VEGF | 0.000236 | 3.628 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.000259 | 3.586 |
| R-HSA-983189 | Kinesins | 0.001196 | 2.922 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.001431 | 2.844 |
| R-HSA-373755 | Semaphorin interactions | 0.001444 | 2.840 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.001705 | 2.768 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.002384 | 2.623 |
| R-HSA-422475 | Axon guidance | 0.002319 | 2.635 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.002757 | 2.560 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.003018 | 2.520 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.003170 | 2.499 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.003913 | 2.407 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.004062 | 2.391 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.004062 | 2.391 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.003663 | 2.436 |
| R-HSA-9675108 | Nervous system development | 0.004166 | 2.380 |
| R-HSA-162582 | Signal Transduction | 0.004000 | 2.398 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.003892 | 2.410 |
| R-HSA-1640170 | Cell Cycle | 0.004443 | 2.352 |
| R-HSA-9830364 | Formation of the nephric duct | 0.005623 | 2.250 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.006024 | 2.220 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.006417 | 2.193 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.006669 | 2.176 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.008545 | 2.068 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.008545 | 2.068 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 0.011362 | 1.945 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.013057 | 1.884 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.013057 | 1.884 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.014746 | 1.831 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.014746 | 1.831 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.014746 | 1.831 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.014746 | 1.831 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.014746 | 1.831 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.014746 | 1.831 |
| R-HSA-390522 | Striated Muscle Contraction | 0.011214 | 1.950 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.013057 | 1.884 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.014746 | 1.831 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.012780 | 1.893 |
| R-HSA-3371511 | HSF1 activation | 0.013591 | 1.867 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.009774 | 2.010 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.012367 | 1.908 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.012367 | 1.908 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.010249 | 1.989 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.010806 | 1.966 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.009955 | 2.002 |
| R-HSA-8953854 | Metabolism of RNA | 0.009655 | 2.015 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.013592 | 1.867 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.013057 | 1.884 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.014383 | 1.842 |
| R-HSA-9711097 | Cellular response to starvation | 0.016367 | 1.786 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.015695 | 1.804 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.015175 | 1.819 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.016524 | 1.782 |
| R-HSA-3371568 | Attenuation phase | 0.017173 | 1.765 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.018038 | 1.744 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.018143 | 1.741 |
| R-HSA-3371556 | Cellular response to heat stress | 0.020131 | 1.696 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.020337 | 1.692 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.022595 | 1.646 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.022595 | 1.646 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.022595 | 1.646 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.022595 | 1.646 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.022595 | 1.646 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.022476 | 1.648 |
| R-HSA-373752 | Netrin-1 signaling | 0.022322 | 1.651 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 0.033702 | 1.472 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.033702 | 1.472 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.033702 | 1.472 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.026668 | 1.574 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.026668 | 1.574 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.028549 | 1.544 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.029453 | 1.531 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.033239 | 1.478 |
| R-HSA-156902 | Peptide chain elongation | 0.025936 | 1.586 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.031273 | 1.505 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.033480 | 1.475 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.034228 | 1.466 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.028934 | 1.539 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.030792 | 1.512 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.034228 | 1.466 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.028934 | 1.539 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.034228 | 1.466 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.030374 | 1.517 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.028934 | 1.539 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.033239 | 1.478 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.033480 | 1.475 |
| R-HSA-445144 | Signal transduction by L1 | 0.033684 | 1.473 |
| R-HSA-72312 | rRNA processing | 0.026706 | 1.573 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.033684 | 1.473 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.028549 | 1.544 |
| R-HSA-373753 | Nephrin family interactions | 0.033684 | 1.473 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.033684 | 1.473 |
| R-HSA-168255 | Influenza Infection | 0.027133 | 1.567 |
| R-HSA-2262752 | Cellular responses to stress | 0.029512 | 1.530 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.028549 | 1.544 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.035197 | 1.453 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.035197 | 1.453 |
| R-HSA-9664407 | Parasite infection | 0.035197 | 1.453 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.036166 | 1.442 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.036166 | 1.442 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.036166 | 1.442 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.041332 | 1.384 |
| R-HSA-192823 | Viral mRNA Translation | 0.042753 | 1.369 |
| R-HSA-68886 | M Phase | 0.043170 | 1.365 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.040519 | 1.392 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.037673 | 1.424 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.041332 | 1.384 |
| R-HSA-186712 | Regulation of beta-cell development | 0.042250 | 1.374 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.044682 | 1.350 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.044682 | 1.350 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.044682 | 1.350 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.044682 | 1.350 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.044682 | 1.350 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.044682 | 1.350 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.044682 | 1.350 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.044682 | 1.350 |
| R-HSA-5619098 | Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) | 0.044682 | 1.350 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.044682 | 1.350 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.044682 | 1.350 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.044682 | 1.350 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.048636 | 1.313 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.052425 | 1.280 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.052425 | 1.280 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.044013 | 1.356 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.046756 | 1.330 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 0.044682 | 1.350 |
| R-HSA-202403 | TCR signaling | 0.052369 | 1.281 |
| R-HSA-397014 | Muscle contraction | 0.051560 | 1.288 |
| R-HSA-74160 | Gene expression (Transcription) | 0.045444 | 1.343 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.048673 | 1.313 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.049561 | 1.305 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.052425 | 1.280 |
| R-HSA-167021 | PLC-gamma1 signalling | 0.055539 | 1.255 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 0.055539 | 1.255 |
| R-HSA-9734281 | Defective HPRT1 disrupts guanine and hypoxanthine salvage | 0.055539 | 1.255 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.055539 | 1.255 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.055539 | 1.255 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 0.066273 | 1.179 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.066273 | 1.179 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.066273 | 1.179 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.057332 | 1.242 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.054943 | 1.260 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.054943 | 1.260 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.064441 | 1.191 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.060987 | 1.215 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.064441 | 1.191 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.064747 | 1.189 |
| R-HSA-2424491 | DAP12 signaling | 0.064441 | 1.191 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.061357 | 1.212 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.056255 | 1.250 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.060987 | 1.215 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.055347 | 1.257 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.055347 | 1.257 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.058934 | 1.230 |
| R-HSA-9658195 | Leishmania infection | 0.058934 | 1.230 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.053958 | 1.268 |
| R-HSA-1266738 | Developmental Biology | 0.061441 | 1.212 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.055347 | 1.257 |
| R-HSA-9830369 | Kidney development | 0.055546 | 1.255 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.061357 | 1.212 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.066667 | 1.176 |
| R-HSA-68875 | Mitotic Prophase | 0.068816 | 1.162 |
| R-HSA-917937 | Iron uptake and transport | 0.070584 | 1.151 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.070763 | 1.150 |
| R-HSA-1538133 | G0 and Early G1 | 0.070763 | 1.150 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.070763 | 1.150 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.073131 | 1.136 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.073997 | 1.131 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.073997 | 1.131 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.087379 | 1.059 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.097753 | 1.010 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.108010 | 0.967 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.108010 | 0.967 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.108010 | 0.967 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.108010 | 0.967 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.108010 | 0.967 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.108010 | 0.967 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.118150 | 0.928 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.128177 | 0.892 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.138089 | 0.860 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.138089 | 0.860 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.147890 | 0.830 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.147890 | 0.830 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.147890 | 0.830 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.147890 | 0.830 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.167160 | 0.777 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.176632 | 0.753 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.185997 | 0.730 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.195256 | 0.709 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 0.195256 | 0.709 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.204410 | 0.689 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.213460 | 0.671 |
| R-HSA-8853659 | RET signaling | 0.087383 | 1.059 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.222408 | 0.653 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.222408 | 0.653 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.240002 | 0.620 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.240002 | 0.620 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 0.248650 | 0.604 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.248650 | 0.604 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.248650 | 0.604 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.248650 | 0.604 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.248650 | 0.604 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.265652 | 0.576 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.085079 | 1.070 |
| R-HSA-72187 | mRNA 3'-end processing | 0.150607 | 0.822 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.154567 | 0.811 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.298519 | 0.525 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.174648 | 0.758 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.098818 | 1.005 |
| R-HSA-72172 | mRNA Splicing | 0.115514 | 0.937 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.291550 | 0.535 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.291550 | 0.535 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.270494 | 0.568 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.257199 | 0.590 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.182795 | 0.738 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.195256 | 0.709 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.295754 | 0.529 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.138089 | 0.860 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.274010 | 0.562 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.103171 | 0.986 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.090836 | 1.042 |
| R-HSA-6807070 | PTEN Regulation | 0.264418 | 0.578 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.083972 | 1.076 |
| R-HSA-9843745 | Adipogenesis | 0.089281 | 1.049 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.167160 | 0.777 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.080603 | 1.094 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.248650 | 0.604 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.076886 | 1.114 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.124885 | 0.903 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.213460 | 0.671 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.201420 | 0.696 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.087379 | 1.059 |
| R-HSA-167172 | Transcription of the HIV genome | 0.215867 | 0.666 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.241009 | 0.618 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.124885 | 0.903 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.105028 | 0.979 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.228413 | 0.641 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.204410 | 0.689 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.087379 | 1.059 |
| R-HSA-4839744 | Signaling by APC mutants | 0.147890 | 0.830 |
| R-HSA-192905 | vRNP Assembly | 0.147890 | 0.830 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.157580 | 0.802 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.157580 | 0.802 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.167160 | 0.777 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.195256 | 0.709 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.231255 | 0.636 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.290442 | 0.537 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.178714 | 0.748 |
| R-HSA-191859 | snRNP Assembly | 0.178714 | 0.748 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.236806 | 0.626 |
| R-HSA-68877 | Mitotic Prometaphase | 0.225162 | 0.648 |
| R-HSA-203615 | eNOS activation | 0.080603 | 1.094 |
| R-HSA-202433 | Generation of second messenger molecules | 0.101425 | 0.994 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.101425 | 0.994 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.228413 | 0.641 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.170045 | 0.769 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.112326 | 0.950 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.265652 | 0.576 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.186889 | 0.728 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.094328 | 1.025 |
| R-HSA-8981373 | Intestinal hexose absorption | 0.087379 | 1.059 |
| R-HSA-9734207 | Nucleotide salvage defects | 0.118150 | 0.928 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.138089 | 0.860 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.195256 | 0.709 |
| R-HSA-9834899 | Specification of the neural plate border | 0.240002 | 0.620 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.240002 | 0.620 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.298519 | 0.525 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.266279 | 0.575 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.170597 | 0.768 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.190997 | 0.719 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.167160 | 0.777 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.108665 | 0.964 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.140289 | 0.853 |
| R-HSA-3928664 | Ephrin signaling | 0.231255 | 0.636 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.157580 | 0.802 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.213460 | 0.671 |
| R-HSA-162587 | HIV Life Cycle | 0.141819 | 0.848 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.240002 | 0.620 |
| R-HSA-9758941 | Gastrulation | 0.298366 | 0.525 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.292167 | 0.534 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.087379 | 1.059 |
| R-HSA-428540 | Activation of RAC1 | 0.157580 | 0.802 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.167160 | 0.777 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.167160 | 0.777 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.176632 | 0.753 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.185997 | 0.730 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.204410 | 0.689 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.240002 | 0.620 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.282273 | 0.549 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.150607 | 0.822 |
| R-HSA-429947 | Deadenylation of mRNA | 0.290442 | 0.537 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.186889 | 0.728 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.241009 | 0.618 |
| R-HSA-68882 | Mitotic Anaphase | 0.284667 | 0.546 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.249592 | 0.603 |
| R-HSA-2172127 | DAP12 interactions | 0.119771 | 0.922 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.287203 | 0.542 |
| R-HSA-162906 | HIV Infection | 0.154379 | 0.811 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.195256 | 0.709 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.119771 | 0.922 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.213460 | 0.671 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.240002 | 0.620 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.087383 | 1.059 |
| R-HSA-199991 | Membrane Trafficking | 0.083526 | 1.078 |
| R-HSA-69481 | G2/M Checkpoints | 0.081094 | 1.091 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.266279 | 0.575 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.087379 | 1.059 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.147890 | 0.830 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 0.176632 | 0.753 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.185997 | 0.730 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.222408 | 0.653 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.108665 | 0.964 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.131143 | 0.882 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.146668 | 0.834 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.257850 | 0.589 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.182795 | 0.738 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.241009 | 0.618 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 0.298519 | 0.525 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.087379 | 1.059 |
| R-HSA-8963676 | Intestinal absorption | 0.118150 | 0.928 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.128177 | 0.892 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.176632 | 0.753 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.204410 | 0.689 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.213460 | 0.671 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.222408 | 0.653 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.231255 | 0.636 |
| R-HSA-69206 | G1/S Transition | 0.216110 | 0.665 |
| R-HSA-69242 | S Phase | 0.295266 | 0.530 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.265652 | 0.576 |
| R-HSA-1500931 | Cell-Cell communication | 0.188438 | 0.725 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.170045 | 0.769 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.248650 | 0.604 |
| R-HSA-9659379 | Sensory processing of sound | 0.262064 | 0.582 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.265652 | 0.576 |
| R-HSA-168249 | Innate Immune System | 0.203051 | 0.692 |
| R-HSA-1643685 | Disease | 0.171929 | 0.765 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.087379 | 1.059 |
| R-HSA-210990 | PECAM1 interactions | 0.147890 | 0.830 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.185997 | 0.730 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.265652 | 0.576 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.282273 | 0.549 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.166563 | 0.778 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.215867 | 0.666 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.100962 | 0.996 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.145560 | 0.837 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.083972 | 1.076 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.167174 | 0.777 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.166563 | 0.778 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.224225 | 0.649 |
| R-HSA-913531 | Interferon Signaling | 0.093812 | 1.028 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.156181 | 0.806 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.181287 | 0.742 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.175640 | 0.755 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.147890 | 0.830 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.167160 | 0.777 |
| R-HSA-189200 | Cellular hexose transport | 0.274010 | 0.562 |
| R-HSA-9748787 | Azathioprine ADME | 0.142751 | 0.845 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.112417 | 0.949 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.289072 | 0.539 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.199247 | 0.701 |
| R-HSA-4839726 | Chromatin organization | 0.195919 | 0.708 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.118150 | 0.928 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.185997 | 0.730 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.195256 | 0.709 |
| R-HSA-193048 | Androgen biosynthesis | 0.265652 | 0.576 |
| R-HSA-9833482 | PKR-mediated signaling | 0.080816 | 1.093 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.290442 | 0.537 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.190997 | 0.719 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.131665 | 0.881 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.174117 | 0.759 |
| R-HSA-373760 | L1CAM interactions | 0.186983 | 0.728 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.290442 | 0.537 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.290442 | 0.537 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.290442 | 0.537 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.190997 | 0.719 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.287343 | 0.542 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.282273 | 0.549 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.132507 | 0.878 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.166563 | 0.778 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 0.274010 | 0.562 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.087383 | 1.059 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.298519 | 0.525 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.097858 | 1.009 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.156536 | 0.805 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.101425 | 0.994 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.236806 | 0.626 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.080603 | 1.094 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.213460 | 0.671 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.174648 | 0.758 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.241009 | 0.618 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.112383 | 0.949 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.170597 | 0.768 |
| R-HSA-1483255 | PI Metabolism | 0.140289 | 0.853 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.241009 | 0.618 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.150607 | 0.822 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.258295 | 0.588 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.241009 | 0.618 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.207267 | 0.683 |
| R-HSA-75153 | Apoptotic execution phase | 0.127325 | 0.895 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.253636 | 0.596 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.264418 | 0.578 |
| R-HSA-5357801 | Programmed Cell Death | 0.257032 | 0.590 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.097858 | 1.009 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.150607 | 0.822 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.301468 | 0.521 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.301468 | 0.521 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.304151 | 0.517 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.306504 | 0.514 |
| R-HSA-525793 | Myogenesis | 0.306504 | 0.514 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.306504 | 0.514 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.306504 | 0.514 |
| R-HSA-3295583 | TRP channels | 0.306504 | 0.514 |
| R-HSA-70635 | Urea cycle | 0.306504 | 0.514 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.306504 | 0.514 |
| R-HSA-9609507 | Protein localization | 0.310784 | 0.508 |
| R-HSA-202424 | Downstream TCR signaling | 0.312531 | 0.505 |
| R-HSA-73887 | Death Receptor Signaling | 0.313892 | 0.503 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.314399 | 0.503 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.314399 | 0.503 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.314399 | 0.503 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.314399 | 0.503 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.314399 | 0.503 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.314399 | 0.503 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.314399 | 0.503 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.314399 | 0.503 |
| R-HSA-264876 | Insulin processing | 0.314399 | 0.503 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.321248 | 0.493 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.322205 | 0.492 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.322205 | 0.492 |
| R-HSA-77387 | Insulin receptor recycling | 0.322205 | 0.492 |
| R-HSA-622312 | Inflammasomes | 0.322205 | 0.492 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.329222 | 0.483 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.329922 | 0.482 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.329922 | 0.482 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.329922 | 0.482 |
| R-HSA-5334118 | DNA methylation | 0.329922 | 0.482 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.329922 | 0.482 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.329922 | 0.482 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.329922 | 0.482 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.333378 | 0.477 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.337551 | 0.472 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.337551 | 0.472 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.337551 | 0.472 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.337551 | 0.472 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.337551 | 0.472 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.337551 | 0.472 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.337551 | 0.472 |
| R-HSA-109581 | Apoptosis | 0.338766 | 0.470 |
| R-HSA-212436 | Generic Transcription Pathway | 0.341893 | 0.466 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.344981 | 0.462 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.345095 | 0.462 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.345095 | 0.462 |
| R-HSA-186763 | Downstream signal transduction | 0.345095 | 0.462 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.345095 | 0.462 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.345095 | 0.462 |
| R-HSA-157118 | Signaling by NOTCH | 0.346185 | 0.461 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.349927 | 0.456 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.349927 | 0.456 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.352553 | 0.453 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.354044 | 0.451 |
| R-HSA-422356 | Regulation of insulin secretion | 0.354044 | 0.451 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.355217 | 0.450 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.359926 | 0.444 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.359926 | 0.444 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.359926 | 0.444 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.359926 | 0.444 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.359926 | 0.444 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.359926 | 0.444 |
| R-HSA-354192 | Integrin signaling | 0.359926 | 0.444 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.359926 | 0.444 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.359926 | 0.444 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.359926 | 0.444 |
| R-HSA-9733709 | Cardiogenesis | 0.359926 | 0.444 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.362249 | 0.441 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.366337 | 0.436 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.367216 | 0.435 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.367216 | 0.435 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.367216 | 0.435 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.367216 | 0.435 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.367216 | 0.435 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.374423 | 0.427 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.374423 | 0.427 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.374423 | 0.427 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.374423 | 0.427 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.374423 | 0.427 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.374423 | 0.427 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.381549 | 0.418 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.381549 | 0.418 |
| R-HSA-381042 | PERK regulates gene expression | 0.381549 | 0.418 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.381549 | 0.418 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.381549 | 0.418 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.381549 | 0.418 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.386622 | 0.413 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.386622 | 0.413 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.388594 | 0.411 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.388594 | 0.411 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.388594 | 0.411 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.388594 | 0.411 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.388594 | 0.411 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.390645 | 0.408 |
| R-HSA-69239 | Synthesis of DNA | 0.394657 | 0.404 |
| R-HSA-211000 | Gene Silencing by RNA | 0.394657 | 0.404 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.395559 | 0.403 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.395559 | 0.403 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.395559 | 0.403 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 0.395559 | 0.403 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.395559 | 0.403 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.398657 | 0.399 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.398657 | 0.399 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.398657 | 0.399 |
| R-HSA-5663205 | Infectious disease | 0.399733 | 0.398 |
| R-HSA-8875878 | MET promotes cell motility | 0.402445 | 0.395 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.402445 | 0.395 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.402445 | 0.395 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 0.402445 | 0.395 |
| R-HSA-74217 | Purine salvage | 0.402445 | 0.395 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.402445 | 0.395 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.402445 | 0.395 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.402645 | 0.395 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.402645 | 0.395 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.406621 | 0.391 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.406621 | 0.391 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.406633 | 0.391 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.409254 | 0.388 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.409254 | 0.388 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.409254 | 0.388 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.409254 | 0.388 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.409254 | 0.388 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.409254 | 0.388 |
| R-HSA-201556 | Signaling by ALK | 0.409254 | 0.388 |
| R-HSA-72766 | Translation | 0.409265 | 0.388 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.409338 | 0.388 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.413834 | 0.383 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.415985 | 0.381 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.415985 | 0.381 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.415985 | 0.381 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.415985 | 0.381 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.415985 | 0.381 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.415985 | 0.381 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.415985 | 0.381 |
| R-HSA-167169 | HIV Transcription Elongation | 0.415985 | 0.381 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.415985 | 0.381 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.415985 | 0.381 |
| R-HSA-5260271 | Diseases of Immune System | 0.415985 | 0.381 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.415985 | 0.381 |
| R-HSA-9646399 | Aggrephagy | 0.415985 | 0.381 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.422394 | 0.374 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.422639 | 0.374 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.422639 | 0.374 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.422639 | 0.374 |
| R-HSA-983712 | Ion channel transport | 0.424833 | 0.372 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.426304 | 0.370 |
| R-HSA-167161 | HIV Transcription Initiation | 0.429219 | 0.367 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.429219 | 0.367 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.429219 | 0.367 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.429219 | 0.367 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.429219 | 0.367 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.429219 | 0.367 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.430858 | 0.366 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.433465 | 0.363 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.433863 | 0.363 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.434082 | 0.362 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.434082 | 0.362 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.435724 | 0.361 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.435724 | 0.361 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.435724 | 0.361 |
| R-HSA-109582 | Hemostasis | 0.439347 | 0.357 |
| R-HSA-9824446 | Viral Infection Pathways | 0.440314 | 0.356 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.441804 | 0.355 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.442155 | 0.354 |
| R-HSA-9710421 | Defective pyroptosis | 0.442155 | 0.354 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 0.442155 | 0.354 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.442155 | 0.354 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.445139 | 0.352 |
| R-HSA-5693538 | Homology Directed Repair | 0.445643 | 0.351 |
| R-HSA-5683826 | Surfactant metabolism | 0.448513 | 0.348 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.448513 | 0.348 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.454799 | 0.342 |
| R-HSA-774815 | Nucleosome assembly | 0.454799 | 0.342 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.454799 | 0.342 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.454799 | 0.342 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.454799 | 0.342 |
| R-HSA-9824272 | Somitogenesis | 0.454799 | 0.342 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.454799 | 0.342 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.454799 | 0.342 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.454799 | 0.342 |
| R-HSA-73886 | Chromosome Maintenance | 0.457073 | 0.340 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.461014 | 0.336 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.461014 | 0.336 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.461014 | 0.336 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.461014 | 0.336 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.461014 | 0.336 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.461014 | 0.336 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.461014 | 0.336 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.461014 | 0.336 |
| R-HSA-9675135 | Diseases of DNA repair | 0.461014 | 0.336 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.461014 | 0.336 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.461014 | 0.336 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.461014 | 0.336 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.461014 | 0.336 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.463571 | 0.334 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.464618 | 0.333 |
| R-HSA-6798695 | Neutrophil degranulation | 0.465723 | 0.332 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.467158 | 0.331 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.467158 | 0.331 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 0.467158 | 0.331 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.468367 | 0.329 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.471096 | 0.327 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.473232 | 0.325 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.473232 | 0.325 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.473232 | 0.325 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.479238 | 0.319 |
| R-HSA-9766229 | Degradation of CDH1 | 0.479238 | 0.319 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.485176 | 0.314 |
| R-HSA-9679506 | SARS-CoV Infections | 0.487945 | 0.312 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.488350 | 0.311 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.491046 | 0.309 |
| R-HSA-912446 | Meiotic recombination | 0.491046 | 0.309 |
| R-HSA-2514856 | The phototransduction cascade | 0.491046 | 0.309 |
| R-HSA-195721 | Signaling by WNT | 0.493239 | 0.307 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.496850 | 0.304 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.496850 | 0.304 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.496850 | 0.304 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.496850 | 0.304 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.502588 | 0.299 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.502588 | 0.299 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.502588 | 0.299 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.508261 | 0.294 |
| R-HSA-72649 | Translation initiation complex formation | 0.508261 | 0.294 |
| R-HSA-9748784 | Drug ADME | 0.512444 | 0.290 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.513869 | 0.289 |
| R-HSA-9753281 | Paracetamol ADME | 0.513869 | 0.289 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.513869 | 0.289 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.519414 | 0.284 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.519414 | 0.284 |
| R-HSA-75893 | TNF signaling | 0.519414 | 0.284 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.519414 | 0.284 |
| R-HSA-177929 | Signaling by EGFR | 0.519414 | 0.284 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.519414 | 0.284 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.519414 | 0.284 |
| R-HSA-163685 | Integration of energy metabolism | 0.522675 | 0.282 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.522675 | 0.282 |
| R-HSA-168256 | Immune System | 0.523682 | 0.281 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.524896 | 0.280 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.530316 | 0.275 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.530316 | 0.275 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.535674 | 0.271 |
| R-HSA-9033241 | Peroxisomal protein import | 0.535674 | 0.271 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.535674 | 0.271 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.540972 | 0.267 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.540972 | 0.267 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.540972 | 0.267 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.540972 | 0.267 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.540972 | 0.267 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.540972 | 0.267 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.540972 | 0.267 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.546209 | 0.263 |
| R-HSA-450294 | MAP kinase activation | 0.546209 | 0.263 |
| R-HSA-8956321 | Nucleotide salvage | 0.546209 | 0.263 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.550091 | 0.260 |
| R-HSA-1268020 | Mitochondrial protein import | 0.551387 | 0.259 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.551387 | 0.259 |
| R-HSA-186797 | Signaling by PDGF | 0.551387 | 0.259 |
| R-HSA-9707616 | Heme signaling | 0.551387 | 0.259 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.556506 | 0.255 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.556506 | 0.255 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.556506 | 0.255 |
| R-HSA-8963743 | Digestion and absorption | 0.556506 | 0.255 |
| R-HSA-8939211 | ESR-mediated signaling | 0.564180 | 0.249 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.566571 | 0.247 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.566660 | 0.247 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.571518 | 0.243 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.571518 | 0.243 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.573165 | 0.242 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.576408 | 0.239 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.576408 | 0.239 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.576408 | 0.239 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.576408 | 0.239 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.581243 | 0.236 |
| R-HSA-5218859 | Regulated Necrosis | 0.581243 | 0.236 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.582788 | 0.234 |
| R-HSA-69306 | DNA Replication | 0.582788 | 0.234 |
| R-HSA-1989781 | PPARA activates gene expression | 0.589116 | 0.230 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.590750 | 0.229 |
| R-HSA-448424 | Interleukin-17 signaling | 0.590750 | 0.229 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.590750 | 0.229 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.590750 | 0.229 |
| R-HSA-9612973 | Autophagy | 0.592253 | 0.227 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.595146 | 0.225 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.595372 | 0.225 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.595422 | 0.225 |
| R-HSA-8978934 | Metabolism of cofactors | 0.595422 | 0.225 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.595422 | 0.225 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.600041 | 0.222 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.600041 | 0.222 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.601356 | 0.221 |
| R-HSA-877300 | Interferon gamma signaling | 0.601557 | 0.221 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.604608 | 0.219 |
| R-HSA-4086398 | Ca2+ pathway | 0.604608 | 0.219 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.604608 | 0.219 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.604623 | 0.219 |
| R-HSA-5688426 | Deubiquitination | 0.610016 | 0.215 |
| R-HSA-380287 | Centrosome maturation | 0.613587 | 0.212 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.613587 | 0.212 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.613587 | 0.212 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.617999 | 0.209 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.617999 | 0.209 |
| R-HSA-5619102 | SLC transporter disorders | 0.625587 | 0.204 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.626676 | 0.203 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.626676 | 0.203 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.630940 | 0.200 |
| R-HSA-73894 | DNA Repair | 0.633205 | 0.198 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.635156 | 0.197 |
| R-HSA-6806834 | Signaling by MET | 0.635156 | 0.197 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.635156 | 0.197 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.639324 | 0.194 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.640031 | 0.194 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.641074 | 0.193 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.645686 | 0.190 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.645686 | 0.190 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.645686 | 0.190 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.645686 | 0.190 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.645686 | 0.190 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.647518 | 0.189 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.651270 | 0.186 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.651545 | 0.186 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.651545 | 0.186 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.651545 | 0.186 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.655527 | 0.183 |
| R-HSA-1500620 | Meiosis | 0.655527 | 0.183 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.655527 | 0.183 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.663355 | 0.178 |
| R-HSA-446728 | Cell junction organization | 0.663765 | 0.178 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.671006 | 0.173 |
| R-HSA-9663891 | Selective autophagy | 0.671006 | 0.173 |
| R-HSA-392499 | Metabolism of proteins | 0.672767 | 0.172 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.674767 | 0.171 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.678484 | 0.168 |
| R-HSA-1280218 | Adaptive Immune System | 0.680232 | 0.167 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.680272 | 0.167 |
| R-HSA-69275 | G2/M Transition | 0.680746 | 0.167 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.685882 | 0.164 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.689386 | 0.162 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.699931 | 0.155 |
| R-HSA-1483257 | Phospholipid metabolism | 0.699931 | 0.155 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.705758 | 0.151 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.706744 | 0.151 |
| R-HSA-157579 | Telomere Maintenance | 0.710098 | 0.149 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.713414 | 0.147 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.713414 | 0.147 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.713414 | 0.147 |
| R-HSA-190236 | Signaling by FGFR | 0.713414 | 0.147 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.716692 | 0.145 |
| R-HSA-70171 | Glycolysis | 0.719933 | 0.143 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.719933 | 0.143 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.723137 | 0.141 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.726305 | 0.139 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.732532 | 0.135 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.735593 | 0.133 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.735593 | 0.133 |
| R-HSA-9833110 | RSV-host interactions | 0.735593 | 0.133 |
| R-HSA-418346 | Platelet homeostasis | 0.741610 | 0.130 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.746676 | 0.127 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.747491 | 0.126 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.750381 | 0.125 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.753239 | 0.123 |
| R-HSA-8957322 | Metabolism of steroids | 0.754721 | 0.122 |
| R-HSA-418990 | Adherens junctions interactions | 0.757146 | 0.121 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.761617 | 0.118 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.769713 | 0.114 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.772350 | 0.112 |
| R-HSA-70326 | Glucose metabolism | 0.777535 | 0.109 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.777535 | 0.109 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.780083 | 0.108 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.782602 | 0.106 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.782602 | 0.106 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.789989 | 0.102 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.789989 | 0.102 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.797144 | 0.098 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.799451 | 0.097 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.799451 | 0.097 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.799451 | 0.097 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.801749 | 0.096 |
| R-HSA-114608 | Platelet degranulation | 0.804022 | 0.095 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.806268 | 0.094 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.810684 | 0.091 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.810788 | 0.091 |
| R-HSA-1474165 | Reproduction | 0.812855 | 0.090 |
| R-HSA-9909396 | Circadian clock | 0.817121 | 0.088 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.817121 | 0.088 |
| R-HSA-421270 | Cell-cell junction organization | 0.817301 | 0.088 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.819218 | 0.087 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.825160 | 0.083 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.827370 | 0.082 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.835656 | 0.078 |
| R-HSA-1632852 | Macroautophagy | 0.837047 | 0.077 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.844399 | 0.073 |
| R-HSA-2187338 | Visual phototransduction | 0.849695 | 0.071 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.850814 | 0.070 |
| R-HSA-166520 | Signaling by NTRKs | 0.851420 | 0.070 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.856261 | 0.067 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.856479 | 0.067 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.858078 | 0.066 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.858127 | 0.066 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.861345 | 0.065 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.861366 | 0.065 |
| R-HSA-9610379 | HCMV Late Events | 0.866088 | 0.062 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.867626 | 0.062 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.870650 | 0.060 |
| R-HSA-211859 | Biological oxidations | 0.871436 | 0.060 |
| R-HSA-597592 | Post-translational protein modification | 0.873788 | 0.059 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.880702 | 0.055 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.883904 | 0.054 |
| R-HSA-72306 | tRNA processing | 0.886093 | 0.053 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.888697 | 0.051 |
| R-HSA-382551 | Transport of small molecules | 0.891200 | 0.050 |
| R-HSA-611105 | Respiratory electron transport | 0.896159 | 0.048 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.902061 | 0.045 |
| R-HSA-3781865 | Diseases of glycosylation | 0.903123 | 0.044 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.905340 | 0.043 |
| R-HSA-5617833 | Cilium Assembly | 0.909622 | 0.041 |
| R-HSA-9609690 | HCMV Early Events | 0.915688 | 0.038 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.919505 | 0.036 |
| R-HSA-8951664 | Neddylation | 0.937625 | 0.028 |
| R-HSA-449147 | Signaling by Interleukins | 0.939751 | 0.027 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.941140 | 0.026 |
| R-HSA-15869 | Metabolism of nucleotides | 0.947591 | 0.023 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.948196 | 0.023 |
| R-HSA-388396 | GPCR downstream signalling | 0.951840 | 0.021 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.953289 | 0.021 |
| R-HSA-9609646 | HCMV Infection | 0.955457 | 0.020 |
| R-HSA-8978868 | Fatty acid metabolism | 0.957613 | 0.019 |
| R-HSA-416476 | G alpha (q) signalling events | 0.962148 | 0.017 |
| R-HSA-5668914 | Diseases of metabolism | 0.965144 | 0.015 |
| R-HSA-372790 | Signaling by GPCR | 0.974367 | 0.011 |
| R-HSA-112316 | Neuronal System | 0.976780 | 0.010 |
| R-HSA-1474244 | Extracellular matrix organization | 0.982665 | 0.008 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.984577 | 0.007 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.988215 | 0.005 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.991804 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 0.992964 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.995998 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.998808 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.999179 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999849 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999957 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.864 | 0.295 | 2 | 0.882 |
CLK3 |
0.852 | 0.213 | 1 | 0.887 |
KIS |
0.846 | 0.156 | 1 | 0.759 |
DSTYK |
0.844 | 0.144 | 2 | 0.888 |
MOS |
0.840 | 0.083 | 1 | 0.856 |
GCN2 |
0.840 | -0.008 | 2 | 0.833 |
IKKB |
0.839 | -0.004 | -2 | 0.728 |
ERK5 |
0.838 | 0.141 | 1 | 0.888 |
NEK6 |
0.838 | 0.094 | -2 | 0.857 |
PRPK |
0.837 | -0.066 | -1 | 0.847 |
PIM3 |
0.835 | 0.027 | -3 | 0.772 |
NLK |
0.834 | 0.038 | 1 | 0.855 |
RAF1 |
0.834 | -0.045 | 1 | 0.804 |
BMPR2 |
0.834 | 0.068 | -2 | 0.864 |
IKKA |
0.834 | 0.091 | -2 | 0.719 |
CHAK2 |
0.834 | 0.080 | -1 | 0.879 |
GRK1 |
0.834 | 0.111 | -2 | 0.736 |
NEK7 |
0.833 | 0.036 | -3 | 0.804 |
MLK1 |
0.833 | 0.036 | 2 | 0.836 |
CDC7 |
0.833 | -0.045 | 1 | 0.816 |
MTOR |
0.833 | -0.099 | 1 | 0.789 |
ULK2 |
0.833 | -0.060 | 2 | 0.817 |
TBK1 |
0.832 | -0.056 | 1 | 0.701 |
SRPK1 |
0.831 | 0.071 | -3 | 0.698 |
CDKL1 |
0.831 | 0.011 | -3 | 0.750 |
NDR2 |
0.830 | -0.023 | -3 | 0.767 |
ATR |
0.829 | -0.022 | 1 | 0.829 |
CAMK2G |
0.829 | -0.029 | 2 | 0.820 |
CAMK1B |
0.829 | -0.056 | -3 | 0.802 |
IKKE |
0.827 | -0.078 | 1 | 0.689 |
RIPK3 |
0.827 | -0.037 | 3 | 0.723 |
TGFBR2 |
0.827 | 0.033 | -2 | 0.812 |
MST4 |
0.827 | 0.011 | 2 | 0.858 |
CDKL5 |
0.827 | 0.037 | -3 | 0.732 |
PDHK4 |
0.825 | -0.307 | 1 | 0.832 |
FAM20C |
0.824 | 0.094 | 2 | 0.593 |
SKMLCK |
0.824 | 0.009 | -2 | 0.785 |
GRK5 |
0.824 | -0.096 | -3 | 0.854 |
BMPR1B |
0.824 | 0.121 | 1 | 0.774 |
CDK1 |
0.824 | 0.138 | 1 | 0.685 |
NDR1 |
0.824 | -0.036 | -3 | 0.759 |
NIK |
0.824 | -0.076 | -3 | 0.827 |
ULK1 |
0.824 | -0.095 | -3 | 0.776 |
PIM1 |
0.824 | 0.046 | -3 | 0.714 |
MLK3 |
0.823 | 0.040 | 2 | 0.762 |
GRK6 |
0.823 | 0.006 | 1 | 0.823 |
CDK8 |
0.823 | 0.060 | 1 | 0.717 |
PKN3 |
0.823 | -0.042 | -3 | 0.761 |
HIPK4 |
0.822 | 0.004 | 1 | 0.824 |
PKCD |
0.822 | 0.027 | 2 | 0.809 |
SRPK3 |
0.822 | 0.056 | -3 | 0.682 |
SRPK2 |
0.821 | 0.052 | -3 | 0.614 |
ICK |
0.821 | 0.012 | -3 | 0.776 |
GRK4 |
0.821 | -0.011 | -2 | 0.800 |
GRK7 |
0.821 | 0.119 | 1 | 0.776 |
HUNK |
0.820 | -0.089 | 2 | 0.839 |
PRKD1 |
0.820 | -0.028 | -3 | 0.748 |
NUAK2 |
0.820 | -0.062 | -3 | 0.759 |
IRE1 |
0.820 | -0.036 | 1 | 0.815 |
CDK5 |
0.820 | 0.109 | 1 | 0.744 |
MLK4 |
0.820 | 0.068 | 2 | 0.745 |
PLK1 |
0.819 | 0.116 | -2 | 0.855 |
PDHK1 |
0.819 | -0.261 | 1 | 0.820 |
ANKRD3 |
0.819 | -0.027 | 1 | 0.846 |
PRKD2 |
0.819 | -0.005 | -3 | 0.689 |
CAMLCK |
0.819 | -0.064 | -2 | 0.802 |
NEK9 |
0.819 | -0.073 | 2 | 0.860 |
WNK1 |
0.819 | -0.097 | -2 | 0.799 |
ATM |
0.818 | 0.025 | 1 | 0.762 |
ACVR2B |
0.818 | 0.142 | -2 | 0.820 |
PKR |
0.818 | 0.086 | 1 | 0.849 |
ACVR2A |
0.818 | 0.134 | -2 | 0.820 |
CDK2 |
0.818 | 0.128 | 1 | 0.761 |
PKN2 |
0.818 | -0.063 | -3 | 0.775 |
CDK19 |
0.818 | 0.058 | 1 | 0.682 |
RSK2 |
0.817 | -0.026 | -3 | 0.697 |
CDK18 |
0.817 | 0.087 | 1 | 0.669 |
MLK2 |
0.817 | -0.080 | 2 | 0.846 |
DLK |
0.817 | -0.090 | 1 | 0.817 |
AMPKA1 |
0.816 | -0.075 | -3 | 0.776 |
P70S6KB |
0.816 | -0.040 | -3 | 0.720 |
ERK1 |
0.816 | 0.092 | 1 | 0.698 |
DAPK2 |
0.816 | -0.103 | -3 | 0.804 |
DYRK2 |
0.815 | 0.049 | 1 | 0.759 |
RSK3 |
0.814 | -0.055 | -3 | 0.695 |
IRE2 |
0.814 | -0.012 | 2 | 0.772 |
WNK3 |
0.814 | -0.210 | 1 | 0.798 |
BCKDK |
0.814 | -0.155 | -1 | 0.817 |
TTBK2 |
0.814 | -0.119 | 2 | 0.714 |
AURC |
0.814 | 0.015 | -2 | 0.621 |
P38A |
0.814 | 0.080 | 1 | 0.775 |
TSSK2 |
0.814 | -0.051 | -5 | 0.726 |
JNK3 |
0.813 | 0.093 | 1 | 0.709 |
LATS2 |
0.813 | -0.045 | -5 | 0.690 |
PKACG |
0.813 | -0.039 | -2 | 0.703 |
PKCB |
0.813 | 0.003 | 2 | 0.764 |
TGFBR1 |
0.813 | 0.021 | -2 | 0.754 |
CDK3 |
0.813 | 0.164 | 1 | 0.633 |
MARK4 |
0.813 | -0.104 | 4 | 0.755 |
JNK2 |
0.813 | 0.101 | 1 | 0.668 |
P90RSK |
0.812 | -0.065 | -3 | 0.696 |
PRP4 |
0.812 | 0.100 | -3 | 0.790 |
ALK4 |
0.812 | -0.027 | -2 | 0.778 |
ERK2 |
0.811 | 0.067 | 1 | 0.737 |
CHAK1 |
0.811 | -0.043 | 2 | 0.776 |
P38B |
0.811 | 0.093 | 1 | 0.718 |
LATS1 |
0.811 | 0.036 | -3 | 0.768 |
P38G |
0.811 | 0.092 | 1 | 0.606 |
TSSK1 |
0.811 | -0.046 | -3 | 0.792 |
CDK17 |
0.811 | 0.073 | 1 | 0.614 |
MASTL |
0.809 | -0.292 | -2 | 0.772 |
CDK13 |
0.809 | 0.034 | 1 | 0.701 |
PKCG |
0.809 | -0.040 | 2 | 0.753 |
NUAK1 |
0.809 | -0.060 | -3 | 0.702 |
CDK7 |
0.809 | 0.010 | 1 | 0.722 |
RIPK1 |
0.809 | -0.209 | 1 | 0.818 |
PKCZ |
0.808 | -0.029 | 2 | 0.798 |
NIM1 |
0.808 | -0.116 | 3 | 0.717 |
CLK2 |
0.808 | 0.086 | -3 | 0.677 |
PKCA |
0.808 | -0.028 | 2 | 0.752 |
ALK2 |
0.808 | 0.041 | -2 | 0.768 |
HIPK2 |
0.808 | 0.070 | 1 | 0.673 |
HIPK1 |
0.807 | 0.055 | 1 | 0.778 |
PERK |
0.807 | 0.020 | -2 | 0.854 |
CLK4 |
0.807 | 0.018 | -3 | 0.687 |
PRKD3 |
0.807 | -0.049 | -3 | 0.669 |
AMPKA2 |
0.807 | -0.092 | -3 | 0.737 |
PAK1 |
0.807 | -0.056 | -2 | 0.718 |
MEK1 |
0.807 | -0.112 | 2 | 0.874 |
BMPR1A |
0.807 | 0.085 | 1 | 0.750 |
MNK2 |
0.807 | -0.043 | -2 | 0.743 |
MEKK3 |
0.807 | -0.015 | 1 | 0.785 |
PLK3 |
0.807 | 0.020 | 2 | 0.780 |
CLK1 |
0.807 | 0.036 | -3 | 0.666 |
MEKK2 |
0.806 | 0.038 | 2 | 0.840 |
TLK2 |
0.806 | -0.010 | 1 | 0.765 |
YSK4 |
0.806 | -0.094 | 1 | 0.738 |
VRK2 |
0.806 | -0.178 | 1 | 0.886 |
MAPKAPK3 |
0.806 | -0.114 | -3 | 0.690 |
RSK4 |
0.806 | -0.010 | -3 | 0.657 |
CAMK2D |
0.806 | -0.135 | -3 | 0.774 |
MSK2 |
0.805 | -0.073 | -3 | 0.681 |
PKACB |
0.805 | 0.009 | -2 | 0.638 |
PINK1 |
0.805 | -0.047 | 1 | 0.848 |
CAMK2B |
0.805 | -0.026 | 2 | 0.791 |
P38D |
0.805 | 0.107 | 1 | 0.626 |
PLK4 |
0.805 | -0.018 | 2 | 0.679 |
NEK2 |
0.805 | -0.109 | 2 | 0.833 |
PKCH |
0.804 | -0.053 | 2 | 0.757 |
CDK16 |
0.804 | 0.090 | 1 | 0.635 |
MEKK1 |
0.804 | -0.040 | 1 | 0.804 |
BRAF |
0.804 | -0.014 | -4 | 0.802 |
MAPKAPK2 |
0.803 | -0.048 | -3 | 0.650 |
NEK5 |
0.803 | -0.005 | 1 | 0.834 |
PAK3 |
0.803 | -0.108 | -2 | 0.721 |
MELK |
0.803 | -0.098 | -3 | 0.717 |
CK1E |
0.803 | -0.003 | -3 | 0.577 |
HRI |
0.803 | -0.033 | -2 | 0.863 |
GRK2 |
0.802 | -0.044 | -2 | 0.679 |
CAMK4 |
0.802 | -0.151 | -3 | 0.740 |
PRKX |
0.802 | 0.034 | -3 | 0.585 |
AURB |
0.802 | -0.026 | -2 | 0.617 |
CDK12 |
0.801 | 0.030 | 1 | 0.675 |
ZAK |
0.801 | -0.064 | 1 | 0.769 |
TAO3 |
0.801 | 0.029 | 1 | 0.777 |
PHKG1 |
0.801 | -0.124 | -3 | 0.751 |
DYRK1A |
0.801 | 0.019 | 1 | 0.786 |
MNK1 |
0.800 | -0.044 | -2 | 0.762 |
PKG2 |
0.800 | -0.026 | -2 | 0.648 |
AKT2 |
0.800 | -0.023 | -3 | 0.612 |
IRAK4 |
0.799 | -0.062 | 1 | 0.825 |
MYLK4 |
0.799 | -0.074 | -2 | 0.719 |
SGK3 |
0.799 | -0.041 | -3 | 0.688 |
CDK14 |
0.799 | 0.046 | 1 | 0.705 |
GAK |
0.798 | 0.111 | 1 | 0.864 |
CAMK2A |
0.798 | -0.073 | 2 | 0.807 |
QSK |
0.798 | -0.099 | 4 | 0.739 |
MEK5 |
0.798 | -0.180 | 2 | 0.857 |
HIPK3 |
0.798 | 0.007 | 1 | 0.772 |
MSK1 |
0.798 | -0.052 | -3 | 0.678 |
SMG1 |
0.798 | -0.113 | 1 | 0.778 |
PIM2 |
0.797 | -0.025 | -3 | 0.667 |
QIK |
0.797 | -0.192 | -3 | 0.761 |
CDK9 |
0.797 | -0.001 | 1 | 0.710 |
SIK |
0.797 | -0.099 | -3 | 0.679 |
PAK2 |
0.797 | -0.111 | -2 | 0.705 |
MST3 |
0.797 | -0.039 | 2 | 0.841 |
TLK1 |
0.796 | -0.059 | -2 | 0.816 |
PAK6 |
0.796 | -0.057 | -2 | 0.656 |
CAMK1G |
0.796 | -0.073 | -3 | 0.690 |
DYRK1B |
0.795 | 0.031 | 1 | 0.716 |
CK1D |
0.794 | 0.000 | -3 | 0.534 |
AURA |
0.794 | -0.043 | -2 | 0.591 |
DYRK4 |
0.794 | 0.045 | 1 | 0.685 |
DNAPK |
0.794 | -0.051 | 1 | 0.667 |
MARK2 |
0.794 | -0.093 | 4 | 0.679 |
NEK8 |
0.794 | -0.058 | 2 | 0.835 |
PKCT |
0.794 | -0.059 | 2 | 0.766 |
DYRK3 |
0.793 | 0.013 | 1 | 0.778 |
DRAK1 |
0.793 | -0.120 | 1 | 0.725 |
CAMKK1 |
0.793 | -0.064 | -2 | 0.751 |
GSK3A |
0.792 | -0.018 | 4 | 0.329 |
CK1G1 |
0.792 | -0.041 | -3 | 0.586 |
SSTK |
0.792 | -0.054 | 4 | 0.744 |
DCAMKL1 |
0.792 | -0.080 | -3 | 0.698 |
MARK3 |
0.792 | -0.097 | 4 | 0.706 |
EEF2K |
0.792 | 0.031 | 3 | 0.815 |
PASK |
0.791 | -0.042 | -3 | 0.795 |
SMMLCK |
0.791 | -0.077 | -3 | 0.758 |
MPSK1 |
0.791 | -0.020 | 1 | 0.811 |
CK1A2 |
0.791 | -0.008 | -3 | 0.531 |
CDK10 |
0.791 | 0.041 | 1 | 0.693 |
CDK6 |
0.790 | 0.067 | 1 | 0.687 |
MST2 |
0.790 | 0.004 | 1 | 0.776 |
BRSK1 |
0.790 | -0.143 | -3 | 0.715 |
AKT1 |
0.790 | -0.031 | -3 | 0.623 |
ERK7 |
0.790 | 0.016 | 2 | 0.525 |
GRK3 |
0.789 | -0.044 | -2 | 0.625 |
SNRK |
0.789 | -0.234 | 2 | 0.718 |
TAO2 |
0.789 | -0.070 | 2 | 0.862 |
JNK1 |
0.789 | 0.054 | 1 | 0.657 |
PHKG2 |
0.789 | -0.112 | -3 | 0.719 |
BRSK2 |
0.788 | -0.176 | -3 | 0.737 |
TNIK |
0.788 | 0.035 | 3 | 0.849 |
PKACA |
0.788 | -0.017 | -2 | 0.597 |
CHK1 |
0.788 | -0.139 | -3 | 0.725 |
CAMKK2 |
0.788 | -0.085 | -2 | 0.750 |
CK2A2 |
0.788 | 0.042 | 1 | 0.654 |
LKB1 |
0.787 | -0.072 | -3 | 0.795 |
PLK2 |
0.787 | 0.039 | -3 | 0.775 |
WNK4 |
0.787 | -0.198 | -2 | 0.779 |
MAPKAPK5 |
0.787 | -0.174 | -3 | 0.647 |
PDK1 |
0.786 | -0.092 | 1 | 0.793 |
TTK |
0.786 | 0.209 | -2 | 0.858 |
NEK11 |
0.786 | -0.181 | 1 | 0.765 |
TTBK1 |
0.786 | -0.170 | 2 | 0.629 |
MAK |
0.786 | 0.067 | -2 | 0.689 |
IRAK1 |
0.785 | -0.218 | -1 | 0.751 |
P70S6K |
0.784 | -0.094 | -3 | 0.628 |
PKCI |
0.784 | -0.078 | 2 | 0.765 |
MARK1 |
0.784 | -0.150 | 4 | 0.723 |
DCAMKL2 |
0.784 | -0.104 | -3 | 0.719 |
GSK3B |
0.784 | -0.091 | 4 | 0.317 |
GCK |
0.784 | -0.047 | 1 | 0.751 |
DAPK3 |
0.782 | -0.045 | -3 | 0.726 |
HGK |
0.782 | -0.056 | 3 | 0.837 |
MINK |
0.782 | -0.059 | 1 | 0.759 |
PKCE |
0.782 | -0.039 | 2 | 0.738 |
NEK4 |
0.782 | -0.140 | 1 | 0.778 |
MST1 |
0.782 | -0.021 | 1 | 0.762 |
OSR1 |
0.781 | 0.087 | 2 | 0.839 |
CDK4 |
0.781 | 0.036 | 1 | 0.663 |
MEKK6 |
0.781 | -0.131 | 1 | 0.790 |
MAP3K15 |
0.780 | -0.133 | 1 | 0.752 |
LOK |
0.779 | -0.069 | -2 | 0.760 |
NEK1 |
0.779 | -0.092 | 1 | 0.807 |
AKT3 |
0.779 | -0.021 | -3 | 0.553 |
TAK1 |
0.779 | -0.098 | 1 | 0.776 |
LRRK2 |
0.779 | -0.140 | 2 | 0.860 |
CAMK1D |
0.778 | -0.080 | -3 | 0.602 |
PAK5 |
0.777 | -0.087 | -2 | 0.582 |
MOK |
0.776 | 0.022 | 1 | 0.815 |
SLK |
0.776 | -0.066 | -2 | 0.704 |
PDHK3_TYR |
0.776 | 0.118 | 4 | 0.790 |
BUB1 |
0.775 | 0.015 | -5 | 0.686 |
CK2A1 |
0.775 | 0.003 | 1 | 0.626 |
VRK1 |
0.775 | -0.149 | 2 | 0.849 |
PBK |
0.774 | 0.008 | 1 | 0.800 |
SGK1 |
0.773 | -0.030 | -3 | 0.535 |
ROCK2 |
0.773 | -0.024 | -3 | 0.702 |
MRCKB |
0.772 | -0.044 | -3 | 0.661 |
HPK1 |
0.772 | -0.130 | 1 | 0.736 |
KHS1 |
0.772 | -0.071 | 1 | 0.742 |
KHS2 |
0.772 | -0.040 | 1 | 0.745 |
STK33 |
0.772 | -0.143 | 2 | 0.634 |
PAK4 |
0.772 | -0.083 | -2 | 0.593 |
DAPK1 |
0.771 | -0.083 | -3 | 0.714 |
ALPHAK3 |
0.771 | 0.054 | -1 | 0.779 |
BMPR2_TYR |
0.771 | 0.068 | -1 | 0.889 |
YSK1 |
0.771 | -0.109 | 2 | 0.829 |
MAP2K6_TYR |
0.771 | 0.075 | -1 | 0.879 |
PDHK4_TYR |
0.771 | 0.067 | 2 | 0.882 |
MRCKA |
0.771 | -0.049 | -3 | 0.673 |
PKN1 |
0.770 | -0.110 | -3 | 0.642 |
HASPIN |
0.769 | 0.021 | -1 | 0.729 |
MAP2K4_TYR |
0.768 | -0.030 | -1 | 0.858 |
CAMK1A |
0.768 | -0.075 | -3 | 0.588 |
DMPK1 |
0.768 | -0.006 | -3 | 0.691 |
EPHA6 |
0.768 | 0.092 | -1 | 0.871 |
CHK2 |
0.768 | -0.091 | -3 | 0.557 |
TESK1_TYR |
0.767 | -0.085 | 3 | 0.822 |
PDHK1_TYR |
0.767 | 0.021 | -1 | 0.885 |
MEK2 |
0.767 | -0.227 | 2 | 0.850 |
PINK1_TYR |
0.767 | -0.037 | 1 | 0.843 |
BIKE |
0.766 | 0.064 | 1 | 0.765 |
MAP2K7_TYR |
0.766 | -0.163 | 2 | 0.874 |
EPHB4 |
0.765 | 0.084 | -1 | 0.844 |
PKMYT1_TYR |
0.765 | -0.108 | 3 | 0.795 |
NEK3 |
0.764 | -0.163 | 1 | 0.763 |
MYO3B |
0.764 | -0.038 | 2 | 0.831 |
MYO3A |
0.763 | -0.036 | 1 | 0.765 |
ABL2 |
0.763 | 0.076 | -1 | 0.773 |
LIMK2_TYR |
0.763 | -0.043 | -3 | 0.840 |
CSF1R |
0.762 | 0.021 | 3 | 0.780 |
BLK |
0.762 | 0.162 | -1 | 0.800 |
RIPK2 |
0.762 | -0.284 | 1 | 0.720 |
RET |
0.761 | -0.074 | 1 | 0.809 |
LCK |
0.761 | 0.112 | -1 | 0.799 |
TXK |
0.760 | 0.105 | 1 | 0.817 |
ROS1 |
0.760 | -0.029 | 3 | 0.754 |
TYK2 |
0.760 | -0.066 | 1 | 0.807 |
TYRO3 |
0.760 | -0.038 | 3 | 0.776 |
ROCK1 |
0.760 | -0.046 | -3 | 0.672 |
MST1R |
0.759 | -0.080 | 3 | 0.791 |
JAK3 |
0.759 | 0.001 | 1 | 0.785 |
PKG1 |
0.759 | -0.074 | -2 | 0.571 |
YES1 |
0.759 | 0.039 | -1 | 0.790 |
JAK2 |
0.758 | -0.058 | 1 | 0.806 |
INSRR |
0.758 | 0.054 | 3 | 0.718 |
ASK1 |
0.758 | -0.149 | 1 | 0.740 |
LIMK1_TYR |
0.758 | -0.150 | 2 | 0.868 |
SBK |
0.758 | -0.071 | -3 | 0.494 |
CK1A |
0.758 | -0.034 | -3 | 0.456 |
TAO1 |
0.758 | -0.099 | 1 | 0.704 |
FER |
0.757 | 0.014 | 1 | 0.873 |
KDR |
0.757 | 0.013 | 3 | 0.751 |
FGR |
0.757 | -0.004 | 1 | 0.874 |
DDR1 |
0.756 | -0.070 | 4 | 0.750 |
ABL1 |
0.756 | 0.026 | -1 | 0.754 |
HCK |
0.756 | 0.030 | -1 | 0.789 |
MET |
0.755 | 0.027 | 3 | 0.767 |
FLT3 |
0.754 | -0.017 | 3 | 0.774 |
KIT |
0.754 | -0.015 | 3 | 0.772 |
CRIK |
0.754 | -0.058 | -3 | 0.626 |
EPHA4 |
0.754 | 0.022 | 2 | 0.768 |
EPHB3 |
0.753 | 0.037 | -1 | 0.826 |
EPHB2 |
0.753 | 0.056 | -1 | 0.822 |
STLK3 |
0.753 | -0.089 | 1 | 0.731 |
ITK |
0.753 | 0.012 | -1 | 0.767 |
EPHB1 |
0.752 | 0.014 | 1 | 0.848 |
PDGFRB |
0.751 | -0.061 | 3 | 0.787 |
TNK2 |
0.751 | -0.011 | 3 | 0.756 |
SRMS |
0.750 | -0.007 | 1 | 0.848 |
TNNI3K_TYR |
0.750 | -0.022 | 1 | 0.855 |
FGFR2 |
0.750 | -0.055 | 3 | 0.747 |
FYN |
0.750 | 0.097 | -1 | 0.776 |
FLT1 |
0.750 | 0.011 | -1 | 0.852 |
AAK1 |
0.750 | 0.092 | 1 | 0.675 |
YANK3 |
0.749 | -0.098 | 2 | 0.387 |
BMX |
0.748 | 0.010 | -1 | 0.694 |
TNK1 |
0.747 | -0.073 | 3 | 0.748 |
MERTK |
0.747 | -0.014 | 3 | 0.747 |
TEK |
0.746 | -0.103 | 3 | 0.709 |
FGFR1 |
0.746 | -0.086 | 3 | 0.738 |
JAK1 |
0.744 | -0.065 | 1 | 0.731 |
EPHA7 |
0.744 | -0.011 | 2 | 0.781 |
TEC |
0.744 | -0.039 | -1 | 0.671 |
FGFR3 |
0.743 | -0.032 | 3 | 0.729 |
AXL |
0.743 | -0.085 | 3 | 0.753 |
LYN |
0.742 | -0.011 | 3 | 0.686 |
WEE1_TYR |
0.742 | -0.077 | -1 | 0.744 |
FRK |
0.741 | -0.038 | -1 | 0.792 |
EPHA5 |
0.741 | 0.037 | 2 | 0.764 |
DDR2 |
0.741 | 0.018 | 3 | 0.710 |
INSR |
0.741 | -0.059 | 3 | 0.700 |
NTRK1 |
0.741 | -0.071 | -1 | 0.814 |
EPHA3 |
0.741 | -0.059 | 2 | 0.747 |
BTK |
0.740 | -0.131 | -1 | 0.709 |
ALK |
0.740 | -0.103 | 3 | 0.696 |
FLT4 |
0.739 | -0.086 | 3 | 0.724 |
NTRK2 |
0.739 | -0.069 | 3 | 0.732 |
PDGFRA |
0.739 | -0.179 | 3 | 0.790 |
MATK |
0.739 | -0.037 | -1 | 0.719 |
ERBB2 |
0.739 | -0.103 | 1 | 0.761 |
PTK2 |
0.739 | 0.072 | -1 | 0.827 |
EPHA8 |
0.739 | 0.008 | -1 | 0.814 |
LTK |
0.739 | -0.084 | 3 | 0.714 |
SYK |
0.739 | 0.083 | -1 | 0.803 |
NTRK3 |
0.738 | -0.029 | -1 | 0.769 |
CK1G3 |
0.738 | -0.035 | -3 | 0.416 |
EPHA1 |
0.738 | -0.081 | 3 | 0.760 |
NEK10_TYR |
0.737 | -0.157 | 1 | 0.651 |
SRC |
0.736 | -0.007 | -1 | 0.753 |
EGFR |
0.736 | -0.010 | 1 | 0.689 |
FGFR4 |
0.734 | -0.010 | -1 | 0.760 |
PTK6 |
0.732 | -0.181 | -1 | 0.685 |
EPHA2 |
0.730 | 0.003 | -1 | 0.792 |
PTK2B |
0.729 | -0.082 | -1 | 0.716 |
CSK |
0.728 | -0.100 | 2 | 0.778 |
IGF1R |
0.728 | -0.032 | 3 | 0.623 |
ERBB4 |
0.725 | -0.005 | 1 | 0.704 |
ZAP70 |
0.721 | 0.027 | -1 | 0.738 |
CK1G2 |
0.720 | -0.042 | -3 | 0.508 |
YANK2 |
0.720 | -0.112 | 2 | 0.407 |
MUSK |
0.719 | -0.126 | 1 | 0.684 |
FES |
0.708 | -0.116 | -1 | 0.663 |