Motif 728 (n=223)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RU67 | FAM234B | S30 | ochoa | Protein FAM234B | None |
| A4UGR9 | XIRP2 | S2643 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| A6NKT7 | RGPD3 | S928 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H0YHG0 | None | S451 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| H0YHG0 | None | S475 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| J3QQQ9 | None | S23 | ochoa | KOW domain-containing protein | None |
| O00170 | AIP | S53 | psp | AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) | May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein. |
| O00244 | ATOX1 | S44 | ochoa | Copper transport protein ATOX1 (Metal transport protein ATX1) | Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. |
| O14715 | RGPD8 | S927 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O43491 | EPB41L2 | S950 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43633 | CHMP2A | S95 | ochoa | Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. {ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692, ECO:0000305}.; FUNCTION: (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844}. |
| O43768 | ENSA | S67 | ochoa|psp | Alpha-endosulfine (ARPP-19e) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269|PubMed:9653196}. |
| O60669 | SLC16A7 | S457 | ochoa | Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) | Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:32415067, PubMed:9786900). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067). {ECO:0000269|PubMed:32415067, ECO:0000269|PubMed:9786900}. |
| O60832 | DKC1 | S420 | ochoa | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}. |
| O60841 | EIF5B | S588 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75475 | PSIP1 | S496 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O94988 | FAM13A | S727 | ochoa | Protein FAM13A | None |
| O95149 | SNUPN | S41 | ochoa | Snurportin-1 (RNA U transporter 1) | Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:38413582, ECO:0000269|PubMed:9670026}. |
| O95232 | LUC7L3 | S395 | ochoa | Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) | Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}. |
| O95456 | PSMG1 | S180 | ochoa | Proteasome assembly chaperone 1 (PAC-1) (Chromosome 21 leucine-rich protein) (C21-LRP) (Down syndrome critical region protein 2) (Proteasome chaperone homolog 1) (Pba1) | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}. |
| O95684 | CEP43 | S209 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| O95831 | AIFM1 | S375 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| O95983 | MBD3 | S144 | ochoa | Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| O96005 | CLPTM1 | S456 | ochoa | Putative lipid scramblase CLPTM1 (Cleft lip and palate transmembrane protein 1) | Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate (By similarity). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (PubMed:29255114). May play a role in T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8VBZ3, ECO:0000250|UniProtKB:Q96KA5, ECO:0000269|PubMed:29255114}. |
| P03956 | MMP1 | S382 | ochoa | Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase] | Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:1645757, PubMed:2153297, PubMed:2557822). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369). {ECO:0000269|PubMed:1645757, ECO:0000269|PubMed:16807369, ECO:0000269|PubMed:2153297, ECO:0000269|PubMed:2557822}. |
| P04075 | ALDOA | S309 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P05060 | CHGB | S311 | ochoa|psp | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P05198 | EIF2S1 | S161 | ochoa | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}. |
| P05387 | RPLP2 | S44 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P06746 | POLB | S55 | psp | DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) | Repair polymerase that plays a key role in base-excision repair (PubMed:10556592, PubMed:9207062, PubMed:9572863). During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap (PubMed:10556592, PubMed:17526740, PubMed:9556598, PubMed:9572863, PubMed:9614142). Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase (PubMed:9614142). {ECO:0000269|PubMed:10556592, ECO:0000269|PubMed:11805079, ECO:0000269|PubMed:17526740, ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9556598, ECO:0000269|PubMed:9572863, ECO:0000269|PubMed:9614142}. |
| P07900 | HSP90AA1 | Y61 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P07900 | HSP90AA1 | S602 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | Y56 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S594 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P09086 | POU2F2 | S250 | ochoa | POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2) | Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874). {ECO:0000250|UniProtKB:Q00196, ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:2328728, ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:7859290}.; FUNCTION: [Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269|PubMed:1739980}. |
| P09429 | HMGB1 | S46 | psp | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P0DJD0 | RGPD1 | S912 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S920 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10412 | H1-4 | S41 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10809 | HSPD1 | S256 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11142 | HSPA8 | S544 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11171 | EPB41 | S812 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P14859 | POU2F1 | S335 | ochoa|psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P16402 | H1-3 | S42 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S41 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P17480 | UBTF | S546 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P19634 | SLC9A1 | S599 | ochoa | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P20340 | RAB6A | S184 | ochoa | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}. |
| P20810 | CAST | S270 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P20810 | CAST | S507 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P20929 | NEB | S367 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P30307 | CDC25C | S247 | psp | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P30622 | CLIP1 | S197 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P36952 | SERPINB5 | S298 | psp | Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5) | Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| P46013 | MKI67 | S1721 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46100 | ATRX | S930 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46459 | NSF | S207 | ochoa | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}. |
| P46821 | MAP1B | S2280 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S828 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49792 | RANBP2 | S1903 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50502 | ST13 | S76 | ochoa|psp | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| P51587 | BRCA2 | S879 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P53367 | ARFIP1 | S44 | ochoa | Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) | Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}. |
| P56211 | ARPP19 | S62 | ochoa|psp | cAMP-regulated phosphoprotein 19 (ARPP-19) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (PubMed:38123684). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (PubMed:38123684). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (PubMed:21164014). May indirectly enhance GAP-43 expression (By similarity). {ECO:0000250|UniProtKB:Q712U5, ECO:0000269|PubMed:21164014, ECO:0000269|PubMed:38123684}. |
| P61129 | ZC3H6 | S738 | ochoa | Zinc finger CCCH domain-containing protein 6 | None |
| P61254 | RPL26 | S23 | ochoa | Large ribosomal subunit protein uL24 (60S ribosomal protein L26) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:26100019, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:26100019, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:26100019}. |
| P61981 | YWHAG | S149 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P63104 | YWHAZ | S207 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P82979 | SARNP | S138 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| P82979 | SARNP | S162 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| Q00688 | FKBP3 | S100 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| Q01105 | SET | S161 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q02539 | H1-1 | S42 | ochoa | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q03001 | DST | S2491 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q05519 | SRSF11 | S456 | ochoa | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | May function in pre-mRNA splicing. |
| Q05D32 | CTDSPL2 | S112 | ochoa | CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) | Probable phosphatase. {ECO:0000250}. |
| Q06265 | EXOSC9 | S287 | ochoa | Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. |
| Q08AD1 | CAMSAP2 | S810 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q12955 | ANK3 | S4325 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13464 | ROCK1 | S1146 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13835 | PKP1 | S229 | ochoa | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q14188 | TFDP2 | S117 | ochoa | Transcription factor Dp-2 (E2F dimerization partner 2) | Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000305|PubMed:20176812}. |
| Q14590 | ZNF235 | S122 | ochoa | Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) | May be involved in transcriptional regulation. |
| Q14643 | ITPR1 | S2696 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000250|UniProtKB:P29994, ECO:0000269|PubMed:10620513, ECO:0000269|PubMed:27108797}. |
| Q15003 | NCAPH | S233 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15022 | SUZ12 | S382 | ochoa | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15022 | SUZ12 | S541 | ochoa|psp | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15147 | PLCB4 | S891 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) | Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development (PubMed:35284927). {ECO:0000250|UniProtKB:Q07722, ECO:0000269|PubMed:35284927}. |
| Q15181 | PPA1 | S241 | ochoa | Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) | None |
| Q16891 | IMMT | S106 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q16891 | IMMT | S350 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q2NKX8 | ERCC6L | S769 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q53F19 | NCBP3 | S575 | ochoa | Nuclear cap-binding protein subunit 3 (Protein ELG) | Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}. |
| Q53GQ0 | HSD17B12 | S92 | ochoa | Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1) | Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16166196}. |
| Q567U6 | CCDC93 | S151 | ochoa | Coiled-coil domain-containing protein 93 | Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (PubMed:37172566, PubMed:38459129). The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:25355947, PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947). {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129}.; FUNCTION: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}. |
| Q58EX2 | SDK2 | S1978 | ochoa | Protein sidekick-2 | Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}. |
| Q58FF6 | HSP90AB4P | Y32 | ochoa | Putative heat shock protein HSP 90-beta 4 | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF7 | HSP90AB3P | Y56 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF8 | HSP90AB2P | Y56 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5BKY9 | FAM133B | S185 | ochoa | Protein FAM133B | None |
| Q5SW79 | CEP170 | S667 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T3I0 | GPATCH4 | S128 | ochoa | G patch domain-containing protein 4 | None |
| Q5UIP0 | RIF1 | S1608 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VU43 | PDE4DIP | S740 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q5XKL5 | BTBD8 | S597 | ochoa | BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis) (APache) | Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission. {ECO:0000250|UniProtKB:Q80TK0}. |
| Q5ZPR3 | CD276 | S513 | ochoa | CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276) | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}. |
| Q641Q2 | WASHC2A | S912 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68D51 | DENND2C | S305 | ochoa | DENN domain-containing protein 2C | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q6FIF0 | ZFAND6 | S132 | ochoa | AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3) | Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19285159, ECO:0000269|PubMed:21810480}. |
| Q6ICG6 | KIAA0930 | S328 | ochoa | Uncharacterized protein KIAA0930 | None |
| Q6P0N0 | MIS18BP1 | S1086 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P1L5 | FAM117B | S345 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P996 | PDXDC1 | S718 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6RI45 | BRWD3 | S1579 | ochoa | Bromodomain and WD repeat-containing protein 3 | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}. |
| Q6UB98 | ANKRD12 | S1141 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UXH1 | CRELD2 | S70 | ochoa | Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) | Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698). {ECO:0000250|UniProtKB:Q9CYA0, ECO:0000269|PubMed:16238698}. |
| Q6UXV4 | APOOL | S205 | ochoa | MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979). {ECO:0000269|PubMed:23704930, ECO:0000269|PubMed:25764979}. |
| Q6WKZ4 | RAB11FIP1 | S232 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6XYQ8 | SYT10 | S221 | ochoa | Synaptotagmin-10 (Synaptotagmin X) (SytX) | Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). {ECO:0000250|UniProtKB:O08625, ECO:0000250|UniProtKB:Q9R0N4}. |
| Q6ZRP7 | QSOX2 | S579 | ochoa | Sulfhydryl oxidase 2 (EC 1.8.3.2) (Neuroblastoma-derived sulfhydryl oxidase) (Quiescin Q6-like protein 1) | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. {ECO:0000269|PubMed:14633699}. |
| Q7L7X3 | TAOK1 | S554 | psp | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q7Z3J3 | RGPD4 | S928 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3T8 | ZFYVE16 | S142 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z7L1 | SLFN11 | S142 | ochoa | Schlafen family member 11 (EC 3.1.-.-) | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}. |
| Q86U86 | PBRM1 | S1116 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86V48 | LUZP1 | S611 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q8IUG5 | MYO18B | S502 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IX03 | WWC1 | S654 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8N488 | RYBP | S123 | ochoa | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}. |
| Q8N6T3 | ARFGAP1 | S213 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8ND56 | LSM14A | S347 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NEB9 | PIK3C3 | S249 | ochoa|psp | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8NEZ4 | KMT2C | S3800 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NFY4 | SEMA6D | S713 | ochoa | Semaphorin-6D | Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q76KF0}. |
| Q8WUM9 | SLC20A1 | S299 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
| Q8WZ42 | TTN | S4099 | psp | Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) | Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. {ECO:0000269|PubMed:11846417, ECO:0000269|PubMed:9804419}. |
| Q92794 | KAT6A | S1143 | ochoa | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
| Q96EA4 | SPDL1 | S471 | ochoa | Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1) | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100). {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:30258100}. |
| Q96JB2 | COG3 | S511 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96L73 | NSD1 | S1269 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96NC0 | ZMAT2 | S75 | ochoa | Zinc finger matrin-type protein 2 | Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}. |
| Q96Q89 | KIF20B | S442 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96Q89 | KIF20B | S1712 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96QD5 | DEPDC7 | S486 | ochoa | DEP domain-containing protein 7 (Protein TR2/D15) | None |
| Q96QE3 | ATAD5 | S1027 | ochoa | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}. |
| Q96QZ7 | MAGI1 | S1361 | ochoa | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3) | Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q6RHR9}. |
| Q96RS0 | TGS1 | S412 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q96RS0 | TGS1 | S443 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q96S59 | RANBP9 | S181 | psp | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q96T23 | RSF1 | S314 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99250 | SCN2A | S528 | ochoa | Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). {ECO:0000250|UniProtKB:B1AWN6, ECO:0000269|PubMed:1325650, ECO:0000269|PubMed:17021166, ECO:0000269|PubMed:28256214, ECO:0000269|PubMed:29844171}. |
| Q99666 | RGPD5 | S927 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99700 | ATXN2 | S356 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99741 | CDC6 | S134 | ochoa | Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) | Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
| Q9BT25 | HAUS8 | S311 | psp | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9BVI0 | PHF20 | S158 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9BXS9 | SLC26A6 | S616 | ochoa | Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1) | Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Also mediates intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger also provides a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Also mediates the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH. {ECO:0000250|UniProtKB:Q8CIW6, ECO:0000269|PubMed:20501439, ECO:0000269|PubMed:27681177}.; FUNCTION: [Isoform 4]: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. {ECO:0000269|PubMed:15990874}. |
| Q9BY42 | RTF2 | S214 | ochoa | Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1) | Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q9BYG3 | NIFK | S145 | ochoa | MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK) | None |
| Q9BYW2 | SETD2 | S2463 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZF1 | OSBPL8 | S120 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9BZI7 | UPF3B | S409 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9C0A6 | SETD5 | S193 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0C9 | UBE2O | S411 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9H246 | C1orf21 | S93 | ochoa | Uncharacterized protein C1orf21 (Cell proliferation-inducing gene 13 protein) | None |
| Q9H2G2 | SLK | S446 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2K8 | TAOK3 | S551 | psp | Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:32807497, ECO:0000269|PubMed:34634521, ECO:0000269|PubMed:38166031}. |
| Q9H4G0 | EPB41L1 | S820 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H4Z3 | PCIF1 | S116 | ochoa | mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121) | Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). {ECO:0000269|PubMed:30467178, ECO:0000269|PubMed:30487554, ECO:0000269|PubMed:31279658, ECO:0000269|PubMed:31279659, ECO:0000269|PubMed:33428944}. |
| Q9H501 | ESF1 | S134 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9HAW4 | CLSPN | S950 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9NP61 | ARFGAP3 | S274 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NQ86 | TRIM36 | S279 | ochoa | E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}. |
| Q9NQC7 | CYLD | S568 | psp | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}. |
| Q9NSY1 | BMP2K | S947 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NVP1 | DDX18 | S44 | ochoa | ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) | ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (PubMed:35858569). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (By similarity). {ECO:0000250|UniProtKB:Q8K363, ECO:0000269|PubMed:35858569}. |
| Q9NVP1 | DDX18 | S136 | ochoa | ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) | ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (PubMed:35858569). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (By similarity). {ECO:0000250|UniProtKB:Q8K363, ECO:0000269|PubMed:35858569}. |
| Q9P0U3 | SENP1 | S416 | ochoa | Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) | Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}. |
| Q9P225 | DNAH2 | S340 | ochoa | Dynein axonemal heavy chain 2 (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3) | As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583). Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583). {ECO:0000269|PubMed:30811583}. |
| Q9P266 | JCAD | S696 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2D0 | IBTK | S999 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9UBU7 | DBF4 | S413 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UBW5 | BIN2 | S508 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UHB7 | AFF4 | S308 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UHG0 | DCDC2 | S300 | ochoa | Doublecortin domain-containing protein 2 (Protein RU2S) | Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). {ECO:0000250|UniProtKB:D3ZR10, ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}. |
| Q9UKI9 | POU2F3 | S238 | ochoa | POU domain, class 2, transcription factor 3 (Octamer-binding protein 11) (Oct-11) (Octamer-binding transcription factor 11) (OTF-11) (Transcription factor PLA-1) (Transcription factor Skn-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971). {ECO:0000269|PubMed:11329378, ECO:0000269|PubMed:35576971}. |
| Q9UKV0 | HDAC9 | S220 | ochoa|psp | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Q9UKX7 | NUP50 | S262 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9UKZ1 | CNOT11 | S339 | ochoa | CCR4-NOT transcription complex subunit 11 | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function. |
| Q9UMZ2 | SYNRG | S223 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UNL2 | SSR3 | S105 | ochoa | Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. |
| Q9Y210 | TRPC6 | S847 | ochoa | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y232 | CDYL | S182 | ochoa | Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-) | [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). {ECO:0000250|UniProtKB:Q9WTK2, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:22009739, ECO:0000269|PubMed:28402439, ECO:0000269|PubMed:28803779, ECO:0000269|PubMed:29177481}.; FUNCTION: [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain (PubMed:19808672). {ECO:0000269|PubMed:19808672}.; FUNCTION: [Isoform 3]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin. {ECO:0000269|PubMed:19808672}. |
| Q9Y2J2 | EPB41L3 | S1031 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y388 | RBMX2 | S121 | ochoa | RNA-binding motif protein, X-linked 2 | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9Y450 | HBS1L | S127 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y5B9 | SUPT16H | S650 | ochoa | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
| P14314 | PRKCSH | S451 | Sugiyama | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| P02786 | TFRC | S620 | Sugiyama | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity). {ECO:0000250|UniProtKB:Q62351, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.; FUNCTION: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762, ECO:0000269|PubMed:36779763}.; FUNCTION: (Microbial infection) Acts as a host entry factor for SARS-CoV, MERS-CoV and SARS-CoV-2 viruses that hijack the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762}. |
| P23434 | GCSH | S153 | Sugiyama | Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein) | The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST) (PubMed:36190515). {ECO:0000269|PubMed:1671321, ECO:0000269|PubMed:36190515}. |
| P31948 | STIP1 | S28 | Sugiyama | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P52789 | HK2 | S893 | Sugiyama | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
| P08238 | HSP90AB1 | S206 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P14625 | HSP90B1 | S650 | Sugiyama | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| Q58FF7 | HSP90AB3P | S185 | Sugiyama | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| O94804 | STK10 | S541 | Sugiyama | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| P05771 | PRKCB | S476 | Sugiyama | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| P17252 | PRKCA | S473 | Sugiyama | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| Q9HAV7 | GRPEL1 | Y173 | Sugiyama | GrpE protein homolog 1, mitochondrial (HMGE) (Mt-GrpE#1) | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (PubMed:11311562). {ECO:0000250|UniProtKB:P38523, ECO:0000269|PubMed:11311562}. |
| O15020 | SPTBN2 | S442 | Sugiyama | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| Q01082 | SPTBN1 | S439 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| P13073 | COX4I1 | S74 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| P46778 | RPL21 | S104 | Sugiyama | Large ribosomal subunit protein eL21 (60S ribosomal protein L21) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}. |
| P41743 | PRKCI | S388 | Sugiyama | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| Q8TB72 | PUM2 | S943 | Sugiyama | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| P04150 | NR3C1 | S682 | PSP | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P30040 | ERP29 | S219 | Sugiyama | Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31) | Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER. |
| Q86UP2 | KTN1 | S722 | Sugiyama | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q6VN20 | RANBP10 | S69 | Sugiyama | Ran-binding protein 10 (RanBP10) | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250|UniProtKB:Q6VN19, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q6YHU6 | THADA | S1024 | Sugiyama | tRNA (32-2'-O)-methyltransferase regulator THADA (Gene inducing thyroid adenomas protein) (Thyroid adenoma-associated protein) | Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs. {ECO:0000269|PubMed:25404562}. |
| Q8N5S9 | CAMKK1 | S149 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| P20810 | CAST | S45 | SIGNOR | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| Q9BYT3 | STK33 | S474 | Sugiyama | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 2.549349e-08 | 7.594 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.292038e-06 | 5.889 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 2.019994e-06 | 5.695 |
| R-HSA-75153 | Apoptotic execution phase | 2.200722e-06 | 5.657 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 8.345998e-06 | 5.079 |
| R-HSA-68886 | M Phase | 5.311963e-05 | 4.275 |
| R-HSA-2262752 | Cellular responses to stress | 5.064795e-05 | 4.295 |
| R-HSA-5357801 | Programmed Cell Death | 4.903510e-05 | 4.309 |
| R-HSA-109581 | Apoptosis | 1.149274e-04 | 3.940 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.462498e-04 | 3.835 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.804936e-04 | 3.420 |
| R-HSA-74160 | Gene expression (Transcription) | 4.148641e-04 | 3.382 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.195866e-04 | 3.377 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.926351e-04 | 3.159 |
| R-HSA-68875 | Mitotic Prophase | 1.129993e-03 | 2.947 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.367364e-03 | 2.864 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.719745e-03 | 2.765 |
| R-HSA-68877 | Mitotic Prometaphase | 1.660477e-03 | 2.780 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.926831e-03 | 2.715 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.327638e-03 | 2.633 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.381703e-03 | 2.623 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.593243e-03 | 2.586 |
| R-HSA-422475 | Axon guidance | 2.736676e-03 | 2.563 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.126973e-03 | 2.505 |
| R-HSA-4839726 | Chromatin organization | 2.978640e-03 | 2.526 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.126973e-03 | 2.505 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 4.197528e-03 | 2.377 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.561106e-03 | 2.341 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 5.394166e-03 | 2.268 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 5.394166e-03 | 2.268 |
| R-HSA-9675108 | Nervous system development | 5.232081e-03 | 2.281 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.338341e-03 | 2.273 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 6.400488e-03 | 2.194 |
| R-HSA-69481 | G2/M Checkpoints | 6.382112e-03 | 2.195 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 6.459404e-03 | 2.190 |
| R-HSA-8953854 | Metabolism of RNA | 5.977022e-03 | 2.224 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 6.776111e-03 | 2.169 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 6.756043e-03 | 2.170 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 8.287634e-03 | 2.082 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 7.882777e-03 | 2.103 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 8.466255e-03 | 2.072 |
| R-HSA-212436 | Generic Transcription Pathway | 8.432794e-03 | 2.074 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.034917e-02 | 1.985 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.034917e-02 | 1.985 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.054417e-02 | 1.977 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.259789e-02 | 1.900 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.492540e-02 | 1.826 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.492540e-02 | 1.826 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.461109e-02 | 1.835 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.507777e-02 | 1.822 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.507777e-02 | 1.822 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 1.209463e-02 | 1.917 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.461109e-02 | 1.835 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.239925e-02 | 1.907 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.369374e-02 | 1.863 |
| R-HSA-69275 | G2/M Transition | 1.375478e-02 | 1.862 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.461109e-02 | 1.835 |
| R-HSA-2559583 | Cellular Senescence | 1.169890e-02 | 1.932 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.449536e-02 | 1.839 |
| R-HSA-373760 | L1CAM interactions | 1.507777e-02 | 1.822 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.431851e-02 | 1.844 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.893015e-02 | 1.723 |
| R-HSA-3371556 | Cellular response to heat stress | 1.778772e-02 | 1.750 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.726699e-02 | 1.763 |
| R-HSA-114452 | Activation of BH3-only proteins | 1.793246e-02 | 1.746 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.783485e-02 | 1.749 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.697940e-02 | 1.770 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.695703e-02 | 1.771 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.783485e-02 | 1.749 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.949901e-02 | 1.710 |
| R-HSA-1538133 | G0 and Early G1 | 2.063475e-02 | 1.685 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.967414e-02 | 1.706 |
| R-HSA-191859 | snRNP Assembly | 1.967414e-02 | 1.706 |
| R-HSA-112043 | PLC beta mediated events | 2.162642e-02 | 1.665 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.063475e-02 | 1.685 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.206511e-02 | 1.656 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 2.216487e-02 | 1.654 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.985215e-02 | 1.525 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.985215e-02 | 1.525 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.985215e-02 | 1.525 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.985215e-02 | 1.525 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.985215e-02 | 1.525 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 2.985215e-02 | 1.525 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 2.985215e-02 | 1.525 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 3.099123e-02 | 1.509 |
| R-HSA-69205 | G1/S-Specific Transcription | 2.831462e-02 | 1.548 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.000863e-02 | 1.523 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.369325e-02 | 1.625 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.369325e-02 | 1.625 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.701122e-02 | 1.568 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.497205e-02 | 1.603 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.798323e-02 | 1.553 |
| R-HSA-373756 | SDK interactions | 2.985215e-02 | 1.525 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.185365e-02 | 1.497 |
| R-HSA-8851805 | MET activates RAS signaling | 2.497205e-02 | 1.603 |
| R-HSA-112040 | G-protein mediated events | 2.817583e-02 | 1.550 |
| R-HSA-70171 | Glycolysis | 2.798323e-02 | 1.553 |
| R-HSA-373755 | Semaphorin interactions | 2.369325e-02 | 1.625 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.667314e-02 | 1.574 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.936996e-02 | 1.532 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 2.791574e-02 | 1.554 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.578648e-02 | 1.446 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.604362e-02 | 1.443 |
| R-HSA-3371568 | Attenuation phase | 3.540409e-02 | 1.451 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.714167e-02 | 1.430 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.355359e-02 | 1.474 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.540409e-02 | 1.451 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.715943e-02 | 1.430 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 3.419393e-02 | 1.466 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 3.751934e-02 | 1.426 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3.419393e-02 | 1.466 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 3.419393e-02 | 1.466 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 3.751934e-02 | 1.426 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 3.419393e-02 | 1.466 |
| R-HSA-168255 | Influenza Infection | 3.258589e-02 | 1.487 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.279464e-02 | 1.484 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.355359e-02 | 1.474 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.826010e-02 | 1.417 |
| R-HSA-380287 | Centrosome maturation | 3.856236e-02 | 1.414 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.999531e-02 | 1.398 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.015671e-02 | 1.396 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.126449e-02 | 1.384 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.173819e-02 | 1.379 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.173819e-02 | 1.379 |
| R-HSA-73930 | Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | 4.444371e-02 | 1.352 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.758125e-02 | 1.323 |
| R-HSA-774815 | Nucleosome assembly | 4.758125e-02 | 1.323 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.295125e-02 | 1.367 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 4.452089e-02 | 1.351 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 4.818858e-02 | 1.317 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.794728e-02 | 1.319 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.758125e-02 | 1.323 |
| R-HSA-9659379 | Sensory processing of sound | 4.447424e-02 | 1.352 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 4.540157e-02 | 1.343 |
| R-HSA-70326 | Glucose metabolism | 5.057602e-02 | 1.296 |
| R-HSA-157118 | Signaling by NOTCH | 4.620880e-02 | 1.335 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 4.818858e-02 | 1.317 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 5.196206e-02 | 1.284 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.204078e-02 | 1.284 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.253819e-02 | 1.280 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.299267e-02 | 1.276 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 5.881669e-02 | 1.230 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 5.881669e-02 | 1.230 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 5.881669e-02 | 1.230 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 5.881669e-02 | 1.230 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 5.881669e-02 | 1.230 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 5.881669e-02 | 1.230 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 5.881669e-02 | 1.230 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 5.881669e-02 | 1.230 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 5.881669e-02 | 1.230 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 5.881669e-02 | 1.230 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 5.881669e-02 | 1.230 |
| R-HSA-72187 | mRNA 3'-end processing | 6.403210e-02 | 1.194 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.403210e-02 | 1.194 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.134489e-02 | 1.212 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.891696e-02 | 1.162 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.507298e-02 | 1.187 |
| R-HSA-156902 | Peptide chain elongation | 6.134489e-02 | 1.212 |
| R-HSA-3371571 | HSF1-dependent transactivation | 6.153956e-02 | 1.211 |
| R-HSA-73886 | Chromosome Maintenance | 5.608299e-02 | 1.251 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.608299e-02 | 1.251 |
| R-HSA-194138 | Signaling by VEGF | 6.343437e-02 | 1.198 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 6.803572e-02 | 1.167 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.134489e-02 | 1.212 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 6.403210e-02 | 1.194 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 6.803572e-02 | 1.167 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.088205e-02 | 1.149 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 1.006565e-01 | 0.997 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 1.006565e-01 | 0.997 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 1.141873e-01 | 0.942 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.275154e-01 | 0.894 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 1.275154e-01 | 0.894 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.406437e-01 | 0.852 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 9.005762e-02 | 1.045 |
| R-HSA-9615710 | Late endosomal microautophagy | 9.937946e-02 | 1.003 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.041377e-01 | 0.982 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.089568e-01 | 0.963 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.089568e-01 | 0.963 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.187664e-01 | 0.925 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.187664e-01 | 0.925 |
| R-HSA-390522 | Striated Muscle Contraction | 1.237512e-01 | 0.907 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.237512e-01 | 0.907 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.338675e-01 | 0.873 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.389939e-01 | 0.857 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 8.558167e-02 | 1.068 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.694784e-02 | 1.114 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.542673e-02 | 1.068 |
| R-HSA-192823 | Viral mRNA Translation | 9.663600e-02 | 1.015 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.071942e-01 | 0.970 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.041377e-01 | 0.982 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.194441e-01 | 0.923 |
| R-HSA-8853659 | RET signaling | 1.389939e-01 | 0.857 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.856876e-02 | 1.053 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 8.101595e-02 | 1.091 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 8.101595e-02 | 1.091 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 9.005762e-02 | 1.045 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.902602e-02 | 1.102 |
| R-HSA-72172 | mRNA Splicing | 1.272971e-01 | 0.895 |
| R-HSA-8849473 | PTK6 Expression | 1.406437e-01 | 0.852 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.953326e-02 | 1.099 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.138340e-01 | 0.944 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.902602e-02 | 1.102 |
| R-HSA-6798695 | Neutrophil degranulation | 1.133906e-01 | 0.945 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.194441e-01 | 0.923 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.113203e-02 | 1.091 |
| R-HSA-8949613 | Cristae formation | 9.005762e-02 | 1.045 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.902602e-02 | 1.102 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 9.434103e-02 | 1.025 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.627046e-02 | 1.118 |
| R-HSA-72766 | Translation | 1.486121e-01 | 0.828 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.179431e-01 | 0.928 |
| R-HSA-3371511 | HSF1 activation | 1.389939e-01 | 0.857 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 8.691991e-02 | 1.061 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.406437e-01 | 0.852 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.237512e-01 | 0.907 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.227385e-01 | 0.911 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.034911e-01 | 0.985 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 8.101595e-02 | 1.091 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.796698e-02 | 1.108 |
| R-HSA-71737 | Pyrophosphate hydrolysis | 1.006565e-01 | 0.997 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 1.275154e-01 | 0.894 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 1.237512e-01 | 0.907 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.227385e-01 | 0.911 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 9.434103e-02 | 1.025 |
| R-HSA-199991 | Membrane Trafficking | 8.629217e-02 | 1.064 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.187664e-01 | 0.925 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 1.237512e-01 | 0.907 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.287858e-01 | 0.890 |
| R-HSA-2408557 | Selenocysteine synthesis | 9.207239e-02 | 1.036 |
| R-HSA-9612973 | Autophagy | 1.267214e-01 | 0.897 |
| R-HSA-381042 | PERK regulates gene expression | 1.338675e-01 | 0.873 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.287319e-01 | 0.890 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 1.141873e-01 | 0.942 |
| R-HSA-418360 | Platelet calcium homeostasis | 9.937946e-02 | 1.003 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 1.389939e-01 | 0.857 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 8.846741e-02 | 1.053 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.447202e-01 | 0.839 |
| R-HSA-162587 | HIV Life Cycle | 1.289119e-01 | 0.890 |
| R-HSA-111933 | Calmodulin induced events | 1.389939e-01 | 0.857 |
| R-HSA-9711097 | Cellular response to starvation | 1.311197e-01 | 0.882 |
| R-HSA-111997 | CaM pathway | 1.389939e-01 | 0.857 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.268399e-02 | 1.083 |
| R-HSA-447041 | CHL1 interactions | 1.406437e-01 | 0.852 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 8.273713e-02 | 1.082 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.697960e-02 | 1.013 |
| R-HSA-8863678 | Neurodegenerative Diseases | 7.660821e-02 | 1.116 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 7.660821e-02 | 1.116 |
| R-HSA-111885 | Opioid Signalling | 9.895707e-02 | 1.005 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 9.005762e-02 | 1.045 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.235470e-01 | 0.908 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 9.005762e-02 | 1.045 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.475113e-01 | 0.831 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.187664e-01 | 0.925 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 1.041377e-01 | 0.982 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 9.794772e-02 | 1.009 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.102826e-02 | 1.091 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 9.139371e-02 | 1.039 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.181350e-01 | 0.928 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 7.445717e-02 | 1.128 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.041377e-01 | 0.982 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.540373e-02 | 1.069 |
| R-HSA-5620971 | Pyroptosis | 9.468509e-02 | 1.024 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.139492e-01 | 0.943 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.235130e-01 | 0.908 |
| R-HSA-5218859 | Regulated Necrosis | 1.097656e-01 | 0.960 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.694784e-02 | 1.114 |
| R-HSA-211000 | Gene Silencing by RNA | 1.084973e-01 | 0.965 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.230432e-01 | 0.910 |
| R-HSA-1500931 | Cell-Cell communication | 1.408842e-01 | 0.851 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.287858e-01 | 0.890 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 1.287858e-01 | 0.890 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.394301e-01 | 0.856 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.110741e-01 | 0.954 |
| R-HSA-449147 | Signaling by Interleukins | 1.161083e-01 | 0.935 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.493708e-01 | 0.826 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.493708e-01 | 0.826 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.502215e-01 | 0.823 |
| R-HSA-68882 | Mitotic Anaphase | 1.511497e-01 | 0.821 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.532230e-01 | 0.815 |
| R-HSA-9824446 | Viral Infection Pathways | 1.534414e-01 | 0.814 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.535752e-01 | 0.814 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 1.535752e-01 | 0.814 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.535752e-01 | 0.814 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.535752e-01 | 0.814 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.535752e-01 | 0.814 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.546164e-01 | 0.811 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.546164e-01 | 0.811 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.546164e-01 | 0.811 |
| R-HSA-9613354 | Lipophagy | 1.663130e-01 | 0.779 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.033922e-01 | 0.692 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.153832e-01 | 0.667 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.271945e-01 | 0.644 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.271945e-01 | 0.644 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.502884e-01 | 0.602 |
| R-HSA-9857492 | Protein lipoylation | 2.502884e-01 | 0.602 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.615763e-01 | 0.582 |
| R-HSA-6783984 | Glycine degradation | 2.726949e-01 | 0.564 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.836468e-01 | 0.547 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.836468e-01 | 0.547 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.598972e-01 | 0.796 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.598972e-01 | 0.796 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.050603e-01 | 0.516 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.155268e-01 | 0.501 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.155268e-01 | 0.501 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.155268e-01 | 0.501 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.155268e-01 | 0.501 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.155268e-01 | 0.501 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 2.308038e-01 | 0.637 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.363670e-01 | 0.626 |
| R-HSA-3214815 | HDACs deacetylate histones | 2.475138e-01 | 0.606 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.757138e-01 | 0.755 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.976655e-01 | 0.704 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.457382e-01 | 0.610 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 2.033922e-01 | 0.692 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.663130e-01 | 0.779 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.598972e-01 | 0.796 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.578412e-01 | 0.589 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.578412e-01 | 0.589 |
| R-HSA-162592 | Integration of provirus | 2.033922e-01 | 0.692 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 2.363670e-01 | 0.626 |
| R-HSA-69206 | G1/S Transition | 1.646751e-01 | 0.783 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.386575e-01 | 0.622 |
| R-HSA-6811438 | Intra-Golgi traffic | 1.705552e-01 | 0.768 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.648887e-01 | 0.577 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.155268e-01 | 0.501 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.363670e-01 | 0.626 |
| R-HSA-1268020 | Mitochondrial protein import | 2.865958e-01 | 0.543 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.663130e-01 | 0.779 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 1.788599e-01 | 0.747 |
| R-HSA-192905 | vRNP Assembly | 1.912186e-01 | 0.718 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.153832e-01 | 0.667 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.271945e-01 | 0.644 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.944345e-01 | 0.531 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.921982e-01 | 0.716 |
| R-HSA-912446 | Meiotic recombination | 2.252494e-01 | 0.647 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.781807e-01 | 0.556 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.615789e-01 | 0.582 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.663130e-01 | 0.779 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.986686e-01 | 0.525 |
| R-HSA-157579 | Telomere Maintenance | 2.257860e-01 | 0.646 |
| R-HSA-3214847 | HATs acetylate histones | 2.337303e-01 | 0.631 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.788599e-01 | 0.747 |
| R-HSA-164843 | 2-LTR circle formation | 1.788599e-01 | 0.747 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 2.033922e-01 | 0.692 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 2.033922e-01 | 0.692 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.388286e-01 | 0.622 |
| R-HSA-9710421 | Defective pyroptosis | 1.813276e-01 | 0.742 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.810166e-01 | 0.551 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.086548e-01 | 0.681 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 2.865958e-01 | 0.543 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 2.153832e-01 | 0.667 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 2.726949e-01 | 0.564 |
| R-HSA-392517 | Rap1 signalling | 3.050603e-01 | 0.516 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.613188e-01 | 0.792 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.944345e-01 | 0.531 |
| R-HSA-9683686 | Maturation of spike protein | 1.788599e-01 | 0.747 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 2.033922e-01 | 0.692 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 2.153832e-01 | 0.667 |
| R-HSA-418457 | cGMP effects | 2.388286e-01 | 0.622 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.502884e-01 | 0.602 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.598972e-01 | 0.796 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.652109e-01 | 0.782 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.050603e-01 | 0.516 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.257830e-01 | 0.646 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.788599e-01 | 0.747 |
| R-HSA-418597 | G alpha (z) signalling events | 2.475138e-01 | 0.606 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.037204e-01 | 0.691 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.663130e-01 | 0.779 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.050603e-01 | 0.516 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.050603e-01 | 0.516 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.663130e-01 | 0.779 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 1.912186e-01 | 0.718 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 2.271945e-01 | 0.644 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.976655e-01 | 0.704 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.754339e-01 | 0.560 |
| R-HSA-111996 | Ca-dependent events | 1.759282e-01 | 0.755 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.836468e-01 | 0.547 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.754339e-01 | 0.560 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.663130e-01 | 0.779 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.502884e-01 | 0.602 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.944345e-01 | 0.531 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.946072e-01 | 0.711 |
| R-HSA-1632852 | Macroautophagy | 2.194153e-01 | 0.659 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.865958e-01 | 0.543 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 2.388286e-01 | 0.622 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.836468e-01 | 0.547 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.865958e-01 | 0.543 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.904600e-01 | 0.537 |
| R-HSA-3214858 | RMTs methylate histone arginines | 1.867516e-01 | 0.729 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 1.609973e-01 | 0.793 |
| R-HSA-72312 | rRNA processing | 1.857799e-01 | 0.731 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.271945e-01 | 0.644 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.388286e-01 | 0.622 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 3.050603e-01 | 0.516 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.153832e-01 | 0.667 |
| R-HSA-8876725 | Protein methylation | 2.502884e-01 | 0.602 |
| R-HSA-416700 | Other semaphorin interactions | 2.502884e-01 | 0.602 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.977397e-01 | 0.526 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.849022e-01 | 0.545 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.767887e-01 | 0.558 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 3.068901e-01 | 0.513 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.502884e-01 | 0.602 |
| R-HSA-373753 | Nephrin family interactions | 3.155268e-01 | 0.501 |
| R-HSA-446728 | Cell junction organization | 1.691360e-01 | 0.772 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.754339e-01 | 0.560 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.921706e-01 | 0.534 |
| R-HSA-112316 | Neuronal System | 2.105561e-01 | 0.677 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.944345e-01 | 0.531 |
| R-HSA-421270 | Cell-cell junction organization | 2.304746e-01 | 0.637 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.983684e-01 | 0.525 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.337303e-01 | 0.631 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.648887e-01 | 0.577 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.475138e-01 | 0.606 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.867516e-01 | 0.729 |
| R-HSA-9707616 | Heme signaling | 2.865958e-01 | 0.543 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.068324e-01 | 0.684 |
| R-HSA-9679506 | SARS-CoV Infections | 1.676206e-01 | 0.776 |
| R-HSA-2028269 | Signaling by Hippo | 2.836468e-01 | 0.547 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.033021e-01 | 0.518 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.736254e-01 | 0.760 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.308038e-01 | 0.637 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 2.642635e-01 | 0.578 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.199387e-01 | 0.495 |
| R-HSA-162906 | HIV Infection | 3.206389e-01 | 0.494 |
| R-HSA-5693538 | Homology Directed Repair | 3.233558e-01 | 0.490 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.258363e-01 | 0.487 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.258363e-01 | 0.487 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.258363e-01 | 0.487 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.258363e-01 | 0.487 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 3.258363e-01 | 0.487 |
| R-HSA-210991 | Basigin interactions | 3.258363e-01 | 0.487 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.289170e-01 | 0.483 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.309778e-01 | 0.480 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.309778e-01 | 0.480 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.323257e-01 | 0.478 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.323257e-01 | 0.478 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.323257e-01 | 0.478 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.359911e-01 | 0.474 |
| R-HSA-193048 | Androgen biosynthesis | 3.359911e-01 | 0.474 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.359911e-01 | 0.474 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.364789e-01 | 0.473 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.459935e-01 | 0.461 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.459935e-01 | 0.461 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.474400e-01 | 0.459 |
| R-HSA-4086398 | Ca2+ pathway | 3.474400e-01 | 0.459 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.480530e-01 | 0.458 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.528984e-01 | 0.452 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 3.558460e-01 | 0.449 |
| R-HSA-3000170 | Syndecan interactions | 3.558460e-01 | 0.449 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.579314e-01 | 0.446 |
| R-HSA-917937 | Iron uptake and transport | 3.583409e-01 | 0.446 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.583409e-01 | 0.446 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.637667e-01 | 0.439 |
| R-HSA-114608 | Platelet degranulation | 3.644743e-01 | 0.438 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.655505e-01 | 0.437 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.655505e-01 | 0.437 |
| R-HSA-429947 | Deadenylation of mRNA | 3.655505e-01 | 0.437 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.655505e-01 | 0.437 |
| R-HSA-4086400 | PCP/CE pathway | 3.745658e-01 | 0.426 |
| R-HSA-392499 | Metabolism of proteins | 3.747911e-01 | 0.426 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.751095e-01 | 0.426 |
| R-HSA-420029 | Tight junction interactions | 3.751095e-01 | 0.426 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.751095e-01 | 0.426 |
| R-HSA-2160916 | Hyaluronan degradation | 3.751095e-01 | 0.426 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.751095e-01 | 0.426 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.751095e-01 | 0.426 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 3.751095e-01 | 0.426 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.799375e-01 | 0.420 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.845250e-01 | 0.415 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.845250e-01 | 0.415 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.845250e-01 | 0.415 |
| R-HSA-3295583 | TRP channels | 3.845250e-01 | 0.415 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.845250e-01 | 0.415 |
| R-HSA-9843745 | Adipogenesis | 3.849046e-01 | 0.415 |
| R-HSA-9833482 | PKR-mediated signaling | 3.852899e-01 | 0.414 |
| R-HSA-6806834 | Signaling by MET | 3.852899e-01 | 0.414 |
| R-HSA-9609646 | HCMV Infection | 3.891137e-01 | 0.410 |
| R-HSA-5617833 | Cilium Assembly | 3.903371e-01 | 0.409 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.906222e-01 | 0.408 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.906222e-01 | 0.408 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.937993e-01 | 0.405 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.937993e-01 | 0.405 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.937993e-01 | 0.405 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.937993e-01 | 0.405 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.937993e-01 | 0.405 |
| R-HSA-201451 | Signaling by BMP | 3.937993e-01 | 0.405 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.029343e-01 | 0.395 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.029343e-01 | 0.395 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.029343e-01 | 0.395 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.029343e-01 | 0.395 |
| R-HSA-622312 | Inflammasomes | 4.029343e-01 | 0.395 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 4.029343e-01 | 0.395 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.092161e-01 | 0.388 |
| R-HSA-9609690 | HCMV Early Events | 4.106996e-01 | 0.386 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.106996e-01 | 0.386 |
| R-HSA-1500620 | Meiosis | 4.117396e-01 | 0.385 |
| R-HSA-5334118 | DNA methylation | 4.119323e-01 | 0.385 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.119323e-01 | 0.385 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.119323e-01 | 0.385 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.119323e-01 | 0.385 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 4.119323e-01 | 0.385 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 4.119323e-01 | 0.385 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.169632e-01 | 0.380 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.189805e-01 | 0.378 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.207952e-01 | 0.376 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.207952e-01 | 0.376 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 4.207952e-01 | 0.376 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 4.207952e-01 | 0.376 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 4.207952e-01 | 0.376 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.207952e-01 | 0.376 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.207952e-01 | 0.376 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 4.221635e-01 | 0.375 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.241996e-01 | 0.372 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.273399e-01 | 0.369 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.295250e-01 | 0.367 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.295250e-01 | 0.367 |
| R-HSA-9663891 | Selective autophagy | 4.324920e-01 | 0.364 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.381238e-01 | 0.358 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.411608e-01 | 0.355 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.425144e-01 | 0.354 |
| R-HSA-73884 | Base Excision Repair | 4.427217e-01 | 0.354 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 4.465935e-01 | 0.350 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.465935e-01 | 0.350 |
| R-HSA-9930044 | Nuclear RNA decay | 4.465935e-01 | 0.350 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.465935e-01 | 0.350 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.465935e-01 | 0.350 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 4.465935e-01 | 0.350 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.465935e-01 | 0.350 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.528493e-01 | 0.344 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.549361e-01 | 0.342 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 4.549361e-01 | 0.342 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.628716e-01 | 0.335 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.631534e-01 | 0.334 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.631534e-01 | 0.334 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.631534e-01 | 0.334 |
| R-HSA-203615 | eNOS activation | 4.631534e-01 | 0.334 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 4.631534e-01 | 0.334 |
| R-HSA-2142845 | Hyaluronan metabolism | 4.631534e-01 | 0.334 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 4.631534e-01 | 0.334 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.631534e-01 | 0.334 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.631534e-01 | 0.334 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.631534e-01 | 0.334 |
| R-HSA-397014 | Muscle contraction | 4.674847e-01 | 0.330 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.678424e-01 | 0.330 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.712474e-01 | 0.327 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 4.712474e-01 | 0.327 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 4.712474e-01 | 0.327 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.712474e-01 | 0.327 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.792197e-01 | 0.319 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.792197e-01 | 0.319 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.792197e-01 | 0.319 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.792197e-01 | 0.319 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.792197e-01 | 0.319 |
| R-HSA-69306 | DNA Replication | 4.801198e-01 | 0.319 |
| R-HSA-9609507 | Protein localization | 4.801198e-01 | 0.319 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.825898e-01 | 0.316 |
| R-HSA-597592 | Post-translational protein modification | 4.852678e-01 | 0.314 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.870724e-01 | 0.312 |
| R-HSA-110331 | Cleavage of the damaged purine | 4.870724e-01 | 0.312 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.870724e-01 | 0.312 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.870724e-01 | 0.312 |
| R-HSA-418990 | Adherens junctions interactions | 4.870763e-01 | 0.312 |
| R-HSA-422356 | Regulation of insulin secretion | 4.922810e-01 | 0.308 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.946007e-01 | 0.306 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.948071e-01 | 0.306 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 4.948071e-01 | 0.306 |
| R-HSA-73927 | Depurination | 4.948071e-01 | 0.306 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.948071e-01 | 0.306 |
| R-HSA-9610379 | HCMV Late Events | 4.953485e-01 | 0.305 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.024257e-01 | 0.299 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.024257e-01 | 0.299 |
| R-HSA-69541 | Stabilization of p53 | 5.024257e-01 | 0.299 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.024257e-01 | 0.299 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.099299e-01 | 0.292 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.099299e-01 | 0.292 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 5.099299e-01 | 0.292 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 5.099299e-01 | 0.292 |
| R-HSA-167169 | HIV Transcription Elongation | 5.099299e-01 | 0.292 |
| R-HSA-5260271 | Diseases of Immune System | 5.099299e-01 | 0.292 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.099299e-01 | 0.292 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.099299e-01 | 0.292 |
| R-HSA-9646399 | Aggrephagy | 5.099299e-01 | 0.292 |
| R-HSA-1266738 | Developmental Biology | 5.151029e-01 | 0.288 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.173213e-01 | 0.286 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.173213e-01 | 0.286 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.173213e-01 | 0.286 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.173213e-01 | 0.286 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.173213e-01 | 0.286 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.173213e-01 | 0.286 |
| R-HSA-9694548 | Maturation of spike protein | 5.173213e-01 | 0.286 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.246017e-01 | 0.280 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 5.246017e-01 | 0.280 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 5.246017e-01 | 0.280 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.246017e-01 | 0.280 |
| R-HSA-195721 | Signaling by WNT | 5.285823e-01 | 0.277 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.317727e-01 | 0.274 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.317727e-01 | 0.274 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.317727e-01 | 0.274 |
| R-HSA-73928 | Depyrimidination | 5.317727e-01 | 0.274 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.317727e-01 | 0.274 |
| R-HSA-418346 | Platelet homeostasis | 5.344469e-01 | 0.272 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.344469e-01 | 0.272 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 5.388360e-01 | 0.269 |
| R-HSA-8854214 | TBC/RABGAPs | 5.388360e-01 | 0.269 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.388360e-01 | 0.269 |
| R-HSA-162582 | Signal Transduction | 5.388485e-01 | 0.269 |
| R-HSA-9907900 | Proteasome assembly | 5.457932e-01 | 0.263 |
| R-HSA-69231 | Cyclin D associated events in G1 | 5.457932e-01 | 0.263 |
| R-HSA-69236 | G1 Phase | 5.457932e-01 | 0.263 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.457932e-01 | 0.263 |
| R-HSA-373752 | Netrin-1 signaling | 5.457932e-01 | 0.263 |
| R-HSA-72306 | tRNA processing | 5.468110e-01 | 0.262 |
| R-HSA-8939211 | ESR-mediated signaling | 5.470302e-01 | 0.262 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.526458e-01 | 0.258 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.593955e-01 | 0.252 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 5.593955e-01 | 0.252 |
| R-HSA-9675135 | Diseases of DNA repair | 5.593955e-01 | 0.252 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 5.593955e-01 | 0.252 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 5.593955e-01 | 0.252 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 5.593955e-01 | 0.252 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 5.593955e-01 | 0.252 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.609464e-01 | 0.251 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.660437e-01 | 0.247 |
| R-HSA-70263 | Gluconeogenesis | 5.725921e-01 | 0.242 |
| R-HSA-425410 | Metal ion SLC transporters | 5.725921e-01 | 0.242 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.784204e-01 | 0.238 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 5.790420e-01 | 0.237 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 5.790420e-01 | 0.237 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.790420e-01 | 0.237 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5.790420e-01 | 0.237 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5.790420e-01 | 0.237 |
| R-HSA-109704 | PI3K Cascade | 5.853950e-01 | 0.233 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.910082e-01 | 0.228 |
| R-HSA-9864848 | Complex IV assembly | 5.916525e-01 | 0.228 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.916525e-01 | 0.228 |
| R-HSA-2514856 | The phototransduction cascade | 5.916525e-01 | 0.228 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.978159e-01 | 0.223 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.978159e-01 | 0.223 |
| R-HSA-5688426 | Deubiquitination | 6.003233e-01 | 0.222 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.031727e-01 | 0.220 |
| R-HSA-1221632 | Meiotic synapsis | 6.038867e-01 | 0.219 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.098662e-01 | 0.215 |
| R-HSA-72649 | Translation initiation complex formation | 6.098662e-01 | 0.215 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.098662e-01 | 0.215 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.153417e-01 | 0.211 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.157558e-01 | 0.211 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.179607e-01 | 0.209 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.215569e-01 | 0.207 |
| R-HSA-75893 | TNF signaling | 6.215569e-01 | 0.207 |
| R-HSA-5578775 | Ion homeostasis | 6.215569e-01 | 0.207 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.215569e-01 | 0.207 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.215569e-01 | 0.207 |
| R-HSA-416476 | G alpha (q) signalling events | 6.255228e-01 | 0.204 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.270880e-01 | 0.203 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.270880e-01 | 0.203 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.270880e-01 | 0.203 |
| R-HSA-112399 | IRS-mediated signalling | 6.272707e-01 | 0.203 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 6.328986e-01 | 0.199 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 6.328986e-01 | 0.199 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.384419e-01 | 0.195 |
| R-HSA-180786 | Extension of Telomeres | 6.384419e-01 | 0.195 |
| R-HSA-9033241 | Peroxisomal protein import | 6.384419e-01 | 0.195 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 6.384419e-01 | 0.195 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.428137e-01 | 0.192 |
| R-HSA-8873719 | RAB geranylgeranylation | 6.439018e-01 | 0.191 |
| R-HSA-983189 | Kinesins | 6.439018e-01 | 0.191 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.439018e-01 | 0.191 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.439018e-01 | 0.191 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.439018e-01 | 0.191 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.439018e-01 | 0.191 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.439018e-01 | 0.191 |
| R-HSA-379724 | tRNA Aminoacylation | 6.439018e-01 | 0.191 |
| R-HSA-1442490 | Collagen degradation | 6.492796e-01 | 0.188 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 6.492796e-01 | 0.188 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.492796e-01 | 0.188 |
| R-HSA-1474165 | Reproduction | 6.497446e-01 | 0.187 |
| R-HSA-5576891 | Cardiac conduction | 6.534131e-01 | 0.185 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.570510e-01 | 0.182 |
| R-HSA-9909396 | Circadian clock | 6.570510e-01 | 0.182 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.597937e-01 | 0.181 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 6.597937e-01 | 0.181 |
| R-HSA-8848021 | Signaling by PTK6 | 6.597937e-01 | 0.181 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.597937e-01 | 0.181 |
| R-HSA-2428924 | IGF1R signaling cascade | 6.649325e-01 | 0.177 |
| R-HSA-74751 | Insulin receptor signalling cascade | 6.649325e-01 | 0.177 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 6.699939e-01 | 0.174 |
| R-HSA-163685 | Integration of energy metabolism | 6.747854e-01 | 0.171 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 6.749792e-01 | 0.171 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.798895e-01 | 0.168 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.798895e-01 | 0.168 |
| R-HSA-196071 | Metabolism of steroid hormones | 6.798895e-01 | 0.168 |
| R-HSA-73894 | DNA Repair | 6.842746e-01 | 0.165 |
| R-HSA-167172 | Transcription of the HIV genome | 6.847259e-01 | 0.164 |
| R-HSA-6807070 | PTEN Regulation | 6.850654e-01 | 0.164 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.867969e-01 | 0.163 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.900731e-01 | 0.161 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.917704e-01 | 0.160 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.941814e-01 | 0.159 |
| R-HSA-204005 | COPII-mediated vesicle transport | 6.941814e-01 | 0.159 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.941814e-01 | 0.159 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 6.941814e-01 | 0.159 |
| R-HSA-8978934 | Metabolism of cofactors | 6.988028e-01 | 0.156 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 7.033545e-01 | 0.153 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 7.055211e-01 | 0.151 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.066720e-01 | 0.151 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 7.078378e-01 | 0.150 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.122536e-01 | 0.147 |
| R-HSA-9013694 | Signaling by NOTCH4 | 7.122536e-01 | 0.147 |
| R-HSA-8852135 | Protein ubiquitination | 7.166029e-01 | 0.145 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.166029e-01 | 0.145 |
| R-HSA-69242 | S Phase | 7.174246e-01 | 0.144 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.208867e-01 | 0.142 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.235521e-01 | 0.141 |
| R-HSA-9694635 | Translation of Structural Proteins | 7.251061e-01 | 0.140 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 7.292619e-01 | 0.137 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.292619e-01 | 0.137 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 7.292619e-01 | 0.137 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.295936e-01 | 0.137 |
| R-HSA-73887 | Death Receptor Signaling | 7.354719e-01 | 0.133 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.373868e-01 | 0.132 |
| R-HSA-1989781 | PPARA activates gene expression | 7.383830e-01 | 0.132 |
| R-HSA-977225 | Amyloid fiber formation | 7.413577e-01 | 0.130 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.441234e-01 | 0.128 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.452688e-01 | 0.128 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.469531e-01 | 0.127 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.475208e-01 | 0.126 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.525322e-01 | 0.123 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 7.529151e-01 | 0.123 |
| R-HSA-5663205 | Infectious disease | 7.584134e-01 | 0.120 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.603329e-01 | 0.119 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.639582e-01 | 0.117 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.675288e-01 | 0.115 |
| R-HSA-70268 | Pyruvate metabolism | 7.675288e-01 | 0.115 |
| R-HSA-5619102 | SLC transporter disorders | 7.712344e-01 | 0.113 |
| R-HSA-1236974 | ER-Phagosome pathway | 7.745096e-01 | 0.111 |
| R-HSA-112310 | Neurotransmitter release cycle | 7.779213e-01 | 0.109 |
| R-HSA-1474244 | Extracellular matrix organization | 7.800074e-01 | 0.108 |
| R-HSA-109582 | Hemostasis | 7.812573e-01 | 0.107 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.878510e-01 | 0.104 |
| R-HSA-74752 | Signaling by Insulin receptor | 7.878510e-01 | 0.104 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.878510e-01 | 0.104 |
| R-HSA-168256 | Immune System | 7.907284e-01 | 0.102 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.910616e-01 | 0.102 |
| R-HSA-1474290 | Collagen formation | 7.942238e-01 | 0.100 |
| R-HSA-5389840 | Mitochondrial translation elongation | 8.034274e-01 | 0.095 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 8.034274e-01 | 0.095 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.064032e-01 | 0.093 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.083572e-01 | 0.092 |
| R-HSA-5368286 | Mitochondrial translation initiation | 8.093342e-01 | 0.092 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.093342e-01 | 0.092 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.093342e-01 | 0.092 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.093342e-01 | 0.092 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.116112e-01 | 0.091 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.122209e-01 | 0.090 |
| R-HSA-382556 | ABC-family proteins mediated transport | 8.150641e-01 | 0.089 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.178645e-01 | 0.087 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.178645e-01 | 0.087 |
| R-HSA-168249 | Innate Immune System | 8.184188e-01 | 0.087 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.206226e-01 | 0.086 |
| R-HSA-1483255 | PI Metabolism | 8.206226e-01 | 0.086 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 8.233391e-01 | 0.084 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.260147e-01 | 0.083 |
| R-HSA-9833110 | RSV-host interactions | 8.286499e-01 | 0.082 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 8.312453e-01 | 0.080 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.336743e-01 | 0.079 |
| R-HSA-69239 | Synthesis of DNA | 8.363193e-01 | 0.078 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 8.363193e-01 | 0.078 |
| R-HSA-9700206 | Signaling by ALK in cancer | 8.363193e-01 | 0.078 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 8.387991e-01 | 0.076 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 8.387991e-01 | 0.076 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.387991e-01 | 0.076 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.387991e-01 | 0.076 |
| R-HSA-5419276 | Mitochondrial translation termination | 8.412414e-01 | 0.075 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 8.412414e-01 | 0.075 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 8.436468e-01 | 0.074 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 8.436468e-01 | 0.074 |
| R-HSA-6803157 | Antimicrobial peptides | 8.460160e-01 | 0.073 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.506476e-01 | 0.070 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.509057e-01 | 0.070 |
| R-HSA-1483257 | Phospholipid metabolism | 8.575092e-01 | 0.067 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.594987e-01 | 0.066 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.594987e-01 | 0.066 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.626307e-01 | 0.064 |
| R-HSA-913531 | Interferon Signaling | 8.626307e-01 | 0.064 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.678272e-01 | 0.062 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.678272e-01 | 0.062 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.678272e-01 | 0.062 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.737493e-01 | 0.059 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.737493e-01 | 0.059 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.756640e-01 | 0.058 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.756640e-01 | 0.058 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.775497e-01 | 0.057 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.794584e-01 | 0.056 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.830379e-01 | 0.054 |
| R-HSA-1280218 | Adaptive Immune System | 8.893159e-01 | 0.051 |
| R-HSA-418594 | G alpha (i) signalling events | 8.903624e-01 | 0.050 |
| R-HSA-9717189 | Sensory perception of taste | 8.932900e-01 | 0.049 |
| R-HSA-8957322 | Metabolism of steroids | 8.946876e-01 | 0.048 |
| R-HSA-5368287 | Mitochondrial translation | 9.055805e-01 | 0.043 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.135039e-01 | 0.039 |
| R-HSA-2187338 | Visual phototransduction | 9.189794e-01 | 0.037 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 9.202104e-01 | 0.036 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 9.226167e-01 | 0.035 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 9.237927e-01 | 0.034 |
| R-HSA-446652 | Interleukin-1 family signaling | 9.249508e-01 | 0.034 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.412737e-01 | 0.026 |
| R-HSA-9658195 | Leishmania infection | 9.434593e-01 | 0.025 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.434593e-01 | 0.025 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.441705e-01 | 0.025 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.447610e-01 | 0.025 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.464294e-01 | 0.024 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.464294e-01 | 0.024 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 9.480476e-01 | 0.023 |
| R-HSA-611105 | Respiratory electron transport | 9.503841e-01 | 0.022 |
| R-HSA-1643685 | Disease | 9.523733e-01 | 0.021 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.526774e-01 | 0.021 |
| R-HSA-983712 | Ion channel transport | 9.580905e-01 | 0.019 |
| R-HSA-388396 | GPCR downstream signalling | 9.590440e-01 | 0.018 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.605868e-01 | 0.017 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.661984e-01 | 0.015 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.666934e-01 | 0.015 |
| R-HSA-6805567 | Keratinization | 9.682135e-01 | 0.014 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.739021e-01 | 0.011 |
| R-HSA-8951664 | Neddylation | 9.747605e-01 | 0.011 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.802695e-01 | 0.009 |
| R-HSA-372790 | Signaling by GPCR | 9.808710e-01 | 0.008 |
| R-HSA-382551 | Transport of small molecules | 9.861339e-01 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.865433e-01 | 0.006 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.867833e-01 | 0.006 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.972304e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.978252e-01 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 9.986024e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.999056e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999962e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.867 | 0.395 | 1 | 0.855 |
COT |
0.863 | 0.054 | 2 | 0.815 |
MOS |
0.853 | 0.271 | 1 | 0.809 |
FAM20C |
0.852 | 0.262 | 2 | 0.721 |
CLK3 |
0.851 | 0.146 | 1 | 0.678 |
DSTYK |
0.850 | 0.017 | 2 | 0.830 |
CAMK2G |
0.850 | 0.037 | 2 | 0.814 |
RAF1 |
0.849 | -0.018 | 1 | 0.741 |
PRPK |
0.848 | -0.052 | -1 | 0.843 |
GCN2 |
0.846 | -0.130 | 2 | 0.729 |
PIM3 |
0.846 | 0.044 | -3 | 0.797 |
IKKB |
0.845 | -0.107 | -2 | 0.750 |
CAMK1B |
0.845 | 0.019 | -3 | 0.846 |
BMPR2 |
0.844 | -0.006 | -2 | 0.898 |
TBK1 |
0.844 | -0.125 | 1 | 0.637 |
PDHK4 |
0.844 | -0.180 | 1 | 0.714 |
AMPKA1 |
0.844 | 0.084 | -3 | 0.843 |
ULK2 |
0.844 | -0.133 | 2 | 0.722 |
NEK6 |
0.843 | -0.006 | -2 | 0.878 |
NDR2 |
0.843 | 0.019 | -3 | 0.813 |
MTOR |
0.843 | -0.144 | 1 | 0.638 |
WNK1 |
0.843 | 0.011 | -2 | 0.874 |
MARK4 |
0.842 | 0.051 | 4 | 0.884 |
TSSK2 |
0.842 | 0.128 | -5 | 0.879 |
RIPK3 |
0.841 | -0.047 | 3 | 0.724 |
ATR |
0.841 | -0.033 | 1 | 0.706 |
CAMK2D |
0.841 | 0.035 | -3 | 0.836 |
BMPR1B |
0.841 | 0.261 | 1 | 0.801 |
MST4 |
0.841 | 0.018 | 2 | 0.788 |
NUAK2 |
0.841 | 0.030 | -3 | 0.828 |
PKN3 |
0.840 | -0.000 | -3 | 0.803 |
IKKE |
0.840 | -0.144 | 1 | 0.629 |
NEK7 |
0.840 | -0.098 | -3 | 0.866 |
TGFBR2 |
0.840 | -0.019 | -2 | 0.807 |
GRK5 |
0.840 | 0.012 | -3 | 0.844 |
NLK |
0.840 | -0.063 | 1 | 0.641 |
TSSK1 |
0.839 | 0.098 | -3 | 0.861 |
CAMK2B |
0.839 | 0.127 | 2 | 0.795 |
GRK6 |
0.839 | 0.082 | 1 | 0.774 |
PRKD1 |
0.839 | 0.011 | -3 | 0.787 |
NIK |
0.839 | -0.002 | -3 | 0.875 |
AMPKA2 |
0.838 | 0.068 | -3 | 0.809 |
MLK1 |
0.838 | -0.086 | 2 | 0.741 |
GRK1 |
0.837 | 0.098 | -2 | 0.783 |
LATS2 |
0.837 | 0.022 | -5 | 0.775 |
PIM1 |
0.837 | 0.063 | -3 | 0.749 |
RSK2 |
0.837 | 0.018 | -3 | 0.735 |
SKMLCK |
0.837 | -0.004 | -2 | 0.840 |
PDHK1 |
0.837 | -0.201 | 1 | 0.703 |
CHAK2 |
0.837 | -0.026 | -1 | 0.834 |
PRKD2 |
0.836 | 0.034 | -3 | 0.749 |
CDKL1 |
0.836 | -0.024 | -3 | 0.761 |
PKN2 |
0.835 | -0.010 | -3 | 0.831 |
NDR1 |
0.835 | -0.027 | -3 | 0.810 |
DAPK2 |
0.834 | 0.007 | -3 | 0.853 |
MAPKAPK3 |
0.834 | -0.008 | -3 | 0.751 |
ATM |
0.834 | 0.026 | 1 | 0.698 |
ERK5 |
0.834 | -0.080 | 1 | 0.608 |
HUNK |
0.834 | -0.111 | 2 | 0.742 |
ULK1 |
0.833 | -0.157 | -3 | 0.826 |
WNK3 |
0.833 | -0.157 | 1 | 0.689 |
PKCD |
0.833 | 0.001 | 2 | 0.731 |
CAMLCK |
0.833 | -0.035 | -2 | 0.841 |
ALK2 |
0.832 | 0.245 | -2 | 0.799 |
MAPKAPK2 |
0.832 | 0.034 | -3 | 0.688 |
IKKA |
0.832 | -0.079 | -2 | 0.739 |
NEK9 |
0.832 | -0.125 | 2 | 0.759 |
CAMK2A |
0.832 | 0.081 | 2 | 0.795 |
MELK |
0.831 | 0.015 | -3 | 0.799 |
TGFBR1 |
0.830 | 0.070 | -2 | 0.789 |
CAMK4 |
0.830 | -0.017 | -3 | 0.820 |
PLK1 |
0.830 | -0.017 | -2 | 0.847 |
ALK4 |
0.829 | 0.030 | -2 | 0.824 |
GRK4 |
0.829 | -0.062 | -2 | 0.822 |
CDKL5 |
0.829 | -0.025 | -3 | 0.750 |
BCKDK |
0.829 | -0.157 | -1 | 0.803 |
P90RSK |
0.829 | -0.033 | -3 | 0.730 |
SRPK1 |
0.829 | 0.001 | -3 | 0.701 |
ACVR2B |
0.828 | 0.159 | -2 | 0.808 |
ANKRD3 |
0.828 | -0.126 | 1 | 0.729 |
BMPR1A |
0.828 | 0.273 | 1 | 0.822 |
MASTL |
0.828 | -0.231 | -2 | 0.836 |
P70S6KB |
0.828 | -0.009 | -3 | 0.777 |
ACVR2A |
0.827 | 0.110 | -2 | 0.804 |
MLK3 |
0.827 | -0.035 | 2 | 0.680 |
AURC |
0.827 | 0.034 | -2 | 0.638 |
RSK3 |
0.827 | -0.038 | -3 | 0.724 |
LATS1 |
0.827 | 0.085 | -3 | 0.813 |
PKACG |
0.827 | -0.030 | -2 | 0.726 |
QSK |
0.827 | 0.026 | 4 | 0.865 |
NIM1 |
0.826 | -0.094 | 3 | 0.754 |
RIPK1 |
0.826 | -0.170 | 1 | 0.695 |
TTBK2 |
0.826 | -0.130 | 2 | 0.654 |
PLK3 |
0.826 | -0.011 | 2 | 0.748 |
MLK2 |
0.826 | -0.136 | 2 | 0.740 |
DLK |
0.825 | -0.171 | 1 | 0.712 |
PKR |
0.825 | -0.026 | 1 | 0.694 |
QIK |
0.825 | -0.045 | -3 | 0.842 |
NUAK1 |
0.825 | -0.008 | -3 | 0.779 |
SIK |
0.825 | 0.012 | -3 | 0.749 |
MARK3 |
0.825 | 0.044 | 4 | 0.825 |
ICK |
0.825 | -0.055 | -3 | 0.798 |
IRE1 |
0.825 | -0.101 | 1 | 0.646 |
MNK2 |
0.824 | -0.004 | -2 | 0.785 |
BRSK2 |
0.824 | -0.018 | -3 | 0.817 |
BRSK1 |
0.823 | -0.003 | -3 | 0.776 |
IRE2 |
0.823 | -0.053 | 2 | 0.696 |
DNAPK |
0.823 | 0.005 | 1 | 0.608 |
HIPK4 |
0.822 | -0.077 | 1 | 0.592 |
NEK2 |
0.822 | -0.097 | 2 | 0.732 |
PRKD3 |
0.822 | -0.008 | -3 | 0.721 |
MARK2 |
0.822 | 0.025 | 4 | 0.792 |
SMG1 |
0.822 | -0.026 | 1 | 0.655 |
MNK1 |
0.822 | 0.028 | -2 | 0.800 |
KIS |
0.822 | -0.071 | 1 | 0.510 |
PAK6 |
0.822 | 0.023 | -2 | 0.693 |
CDK8 |
0.821 | -0.080 | 1 | 0.477 |
CHK1 |
0.821 | 0.041 | -3 | 0.801 |
SRPK2 |
0.821 | -0.001 | -3 | 0.624 |
GRK7 |
0.821 | 0.042 | 1 | 0.700 |
YSK4 |
0.821 | -0.126 | 1 | 0.661 |
PAK1 |
0.820 | -0.054 | -2 | 0.762 |
PKCG |
0.820 | -0.037 | 2 | 0.674 |
PKCB |
0.820 | -0.025 | 2 | 0.671 |
PKCA |
0.820 | -0.033 | 2 | 0.664 |
AURB |
0.819 | 0.002 | -2 | 0.634 |
BRAF |
0.819 | 0.042 | -4 | 0.820 |
RSK4 |
0.819 | 0.019 | -3 | 0.702 |
CHAK1 |
0.819 | -0.098 | 2 | 0.689 |
PAK3 |
0.819 | -0.095 | -2 | 0.763 |
CDK1 |
0.818 | -0.020 | 1 | 0.446 |
PHKG1 |
0.818 | -0.071 | -3 | 0.815 |
MSK2 |
0.818 | -0.068 | -3 | 0.694 |
VRK2 |
0.818 | -0.187 | 1 | 0.717 |
MYLK4 |
0.818 | -0.020 | -2 | 0.742 |
PKCH |
0.818 | -0.047 | 2 | 0.656 |
MARK1 |
0.818 | 0.003 | 4 | 0.845 |
MEK1 |
0.818 | -0.157 | 2 | 0.778 |
PKG2 |
0.817 | -0.001 | -2 | 0.661 |
CDK5 |
0.817 | -0.021 | 1 | 0.506 |
MLK4 |
0.817 | -0.104 | 2 | 0.650 |
SRPK3 |
0.817 | -0.018 | -3 | 0.676 |
SSTK |
0.816 | 0.067 | 4 | 0.855 |
JNK2 |
0.816 | -0.034 | 1 | 0.442 |
HRI |
0.816 | -0.097 | -2 | 0.863 |
PERK |
0.815 | -0.078 | -2 | 0.853 |
CLK4 |
0.815 | -0.013 | -3 | 0.739 |
CLK1 |
0.815 | 0.007 | -3 | 0.726 |
CDK19 |
0.815 | -0.082 | 1 | 0.441 |
PKCZ |
0.814 | -0.079 | 2 | 0.702 |
PKACB |
0.814 | 0.011 | -2 | 0.653 |
CLK2 |
0.814 | 0.068 | -3 | 0.715 |
MSK1 |
0.814 | -0.029 | -3 | 0.703 |
DRAK1 |
0.814 | -0.077 | 1 | 0.685 |
CAMK1G |
0.813 | -0.041 | -3 | 0.750 |
CDK7 |
0.813 | -0.087 | 1 | 0.490 |
PAK2 |
0.813 | -0.097 | -2 | 0.751 |
AURA |
0.813 | -0.017 | -2 | 0.600 |
PRKX |
0.813 | 0.055 | -3 | 0.658 |
JNK3 |
0.813 | -0.059 | 1 | 0.476 |
CDK2 |
0.813 | -0.029 | 1 | 0.522 |
DCAMKL1 |
0.813 | -0.008 | -3 | 0.770 |
SNRK |
0.812 | -0.147 | 2 | 0.628 |
PIM2 |
0.812 | 0.000 | -3 | 0.720 |
IRAK4 |
0.812 | -0.081 | 1 | 0.675 |
WNK4 |
0.811 | -0.098 | -2 | 0.877 |
PRP4 |
0.811 | -0.003 | -3 | 0.746 |
NEK5 |
0.811 | -0.089 | 1 | 0.698 |
DYRK2 |
0.811 | -0.087 | 1 | 0.502 |
AKT2 |
0.811 | -0.014 | -3 | 0.660 |
SGK3 |
0.811 | -0.033 | -3 | 0.736 |
CDK13 |
0.811 | -0.090 | 1 | 0.467 |
PHKG2 |
0.810 | -0.026 | -3 | 0.805 |
DCAMKL2 |
0.810 | -0.016 | -3 | 0.803 |
PLK4 |
0.810 | -0.138 | 2 | 0.585 |
MEKK3 |
0.809 | -0.169 | 1 | 0.675 |
CK2A2 |
0.809 | 0.112 | 1 | 0.666 |
CDK3 |
0.809 | 0.012 | 1 | 0.393 |
P38A |
0.809 | -0.068 | 1 | 0.506 |
MST3 |
0.809 | -0.049 | 2 | 0.757 |
CAMK1D |
0.809 | 0.022 | -3 | 0.676 |
ZAK |
0.808 | -0.151 | 1 | 0.668 |
CDK18 |
0.808 | -0.060 | 1 | 0.419 |
MEKK1 |
0.808 | -0.184 | 1 | 0.684 |
TLK2 |
0.808 | -0.171 | 1 | 0.668 |
P38B |
0.807 | -0.054 | 1 | 0.443 |
TAO3 |
0.807 | -0.047 | 1 | 0.665 |
MEK5 |
0.807 | -0.247 | 2 | 0.752 |
TTBK1 |
0.807 | -0.122 | 2 | 0.586 |
MAPKAPK5 |
0.806 | -0.136 | -3 | 0.687 |
GRK2 |
0.805 | -0.099 | -2 | 0.686 |
PINK1 |
0.805 | -0.168 | 1 | 0.625 |
EEF2K |
0.805 | 0.082 | 3 | 0.850 |
SMMLCK |
0.805 | -0.057 | -3 | 0.802 |
ERK1 |
0.804 | -0.080 | 1 | 0.436 |
CAMKK1 |
0.804 | -0.098 | -2 | 0.780 |
MEKK2 |
0.804 | -0.175 | 2 | 0.729 |
CDK17 |
0.804 | -0.074 | 1 | 0.373 |
PKCT |
0.803 | -0.072 | 2 | 0.665 |
ERK2 |
0.803 | -0.105 | 1 | 0.476 |
NEK8 |
0.803 | -0.122 | 2 | 0.745 |
TAO2 |
0.803 | -0.036 | 2 | 0.789 |
IRAK1 |
0.803 | -0.171 | -1 | 0.773 |
AKT1 |
0.803 | -0.013 | -3 | 0.684 |
PASK |
0.803 | -0.021 | -3 | 0.817 |
CK1E |
0.802 | -0.036 | -3 | 0.544 |
GAK |
0.802 | -0.018 | 1 | 0.690 |
P38G |
0.802 | -0.071 | 1 | 0.368 |
TLK1 |
0.802 | -0.150 | -2 | 0.817 |
P70S6K |
0.802 | -0.055 | -3 | 0.679 |
CDK12 |
0.802 | -0.096 | 1 | 0.442 |
CDK9 |
0.801 | -0.115 | 1 | 0.475 |
LKB1 |
0.801 | -0.074 | -3 | 0.867 |
PKCI |
0.800 | -0.064 | 2 | 0.670 |
CDK16 |
0.800 | -0.027 | 1 | 0.392 |
MPSK1 |
0.800 | -0.067 | 1 | 0.607 |
PKACA |
0.800 | -0.011 | -2 | 0.601 |
DAPK3 |
0.799 | 0.028 | -3 | 0.781 |
GCK |
0.799 | -0.055 | 1 | 0.661 |
GSK3B |
0.799 | -0.010 | 4 | 0.494 |
HIPK1 |
0.799 | -0.079 | 1 | 0.514 |
CDK14 |
0.799 | -0.068 | 1 | 0.459 |
CK2A1 |
0.799 | 0.078 | 1 | 0.635 |
TNIK |
0.798 | -0.010 | 3 | 0.857 |
DYRK1A |
0.798 | -0.088 | 1 | 0.551 |
PKCE |
0.798 | -0.015 | 2 | 0.659 |
CAMKK2 |
0.798 | -0.117 | -2 | 0.774 |
PAK5 |
0.798 | -0.053 | -2 | 0.625 |
HIPK2 |
0.798 | -0.069 | 1 | 0.422 |
P38D |
0.797 | -0.054 | 1 | 0.391 |
PLK2 |
0.797 | -0.017 | -3 | 0.748 |
MINK |
0.797 | -0.076 | 1 | 0.661 |
HGK |
0.797 | -0.064 | 3 | 0.851 |
NEK4 |
0.797 | -0.136 | 1 | 0.660 |
TAK1 |
0.797 | -0.067 | 1 | 0.719 |
CDK10 |
0.796 | -0.036 | 1 | 0.446 |
PKN1 |
0.796 | -0.040 | -3 | 0.707 |
CK1D |
0.796 | -0.029 | -3 | 0.500 |
MST2 |
0.796 | -0.105 | 1 | 0.689 |
NEK1 |
0.796 | -0.070 | 1 | 0.680 |
PDK1 |
0.795 | -0.109 | 1 | 0.700 |
HIPK3 |
0.795 | -0.109 | 1 | 0.526 |
NEK11 |
0.795 | -0.218 | 1 | 0.671 |
GSK3A |
0.795 | -0.002 | 4 | 0.502 |
PAK4 |
0.794 | -0.048 | -2 | 0.628 |
DYRK4 |
0.794 | -0.078 | 1 | 0.438 |
ERK7 |
0.793 | -0.055 | 2 | 0.460 |
VRK1 |
0.793 | -0.092 | 2 | 0.779 |
DYRK1B |
0.793 | -0.092 | 1 | 0.463 |
LOK |
0.792 | -0.068 | -2 | 0.789 |
HPK1 |
0.792 | -0.072 | 1 | 0.648 |
CAMK1A |
0.792 | -0.005 | -3 | 0.626 |
DAPK1 |
0.792 | -0.007 | -3 | 0.762 |
GRK3 |
0.792 | -0.087 | -2 | 0.632 |
MRCKA |
0.791 | -0.004 | -3 | 0.739 |
CK1G1 |
0.791 | -0.100 | -3 | 0.526 |
PDHK3_TYR |
0.791 | 0.116 | 4 | 0.916 |
CDK6 |
0.791 | -0.047 | 1 | 0.445 |
KHS1 |
0.790 | -0.036 | 1 | 0.646 |
KHS2 |
0.790 | -0.004 | 1 | 0.648 |
MST1 |
0.790 | -0.106 | 1 | 0.661 |
MAP3K15 |
0.790 | -0.164 | 1 | 0.653 |
MRCKB |
0.789 | -0.009 | -3 | 0.725 |
LRRK2 |
0.789 | -0.150 | 2 | 0.776 |
CHK2 |
0.789 | -0.044 | -3 | 0.607 |
DYRK3 |
0.789 | -0.092 | 1 | 0.518 |
CK1A2 |
0.788 | -0.059 | -3 | 0.498 |
ROCK2 |
0.788 | 0.001 | -3 | 0.766 |
MEKK6 |
0.788 | -0.182 | 1 | 0.659 |
STK33 |
0.787 | -0.144 | 2 | 0.565 |
RIPK2 |
0.787 | -0.207 | 1 | 0.648 |
BUB1 |
0.787 | 0.019 | -5 | 0.811 |
JNK1 |
0.787 | -0.083 | 1 | 0.430 |
AKT3 |
0.786 | -0.025 | -3 | 0.580 |
YSK1 |
0.786 | -0.105 | 2 | 0.730 |
PBK |
0.786 | -0.048 | 1 | 0.617 |
CDK4 |
0.786 | -0.065 | 1 | 0.425 |
SLK |
0.785 | -0.100 | -2 | 0.735 |
SGK1 |
0.784 | -0.030 | -3 | 0.563 |
ALPHAK3 |
0.784 | 0.170 | -1 | 0.760 |
TESK1_TYR |
0.783 | -0.026 | 3 | 0.851 |
TTK |
0.782 | 0.011 | -2 | 0.843 |
MEK2 |
0.782 | -0.208 | 2 | 0.743 |
EPHA6 |
0.782 | 0.160 | -1 | 0.868 |
PDHK4_TYR |
0.781 | 0.000 | 2 | 0.824 |
DMPK1 |
0.781 | 0.022 | -3 | 0.748 |
MAP2K4_TYR |
0.780 | -0.038 | -1 | 0.863 |
SBK |
0.780 | -0.019 | -3 | 0.533 |
NEK3 |
0.780 | -0.148 | 1 | 0.641 |
MAP2K6_TYR |
0.778 | -0.041 | -1 | 0.854 |
MAP2K7_TYR |
0.778 | -0.185 | 2 | 0.808 |
MAK |
0.778 | -0.027 | -2 | 0.753 |
EPHB4 |
0.778 | 0.124 | -1 | 0.875 |
PDHK1_TYR |
0.778 | -0.035 | -1 | 0.877 |
EPHA4 |
0.778 | 0.199 | 2 | 0.752 |
PKG1 |
0.777 | -0.058 | -2 | 0.584 |
TXK |
0.776 | 0.152 | 1 | 0.756 |
LIMK2_TYR |
0.776 | -0.048 | -3 | 0.892 |
PINK1_TYR |
0.776 | -0.159 | 1 | 0.707 |
PKMYT1_TYR |
0.776 | -0.149 | 3 | 0.808 |
MOK |
0.775 | -0.055 | 1 | 0.520 |
TYRO3 |
0.775 | -0.002 | 3 | 0.760 |
ROCK1 |
0.774 | -0.026 | -3 | 0.738 |
BMPR2_TYR |
0.774 | -0.104 | -1 | 0.826 |
EPHB3 |
0.774 | 0.166 | -1 | 0.869 |
EPHB1 |
0.774 | 0.131 | 1 | 0.794 |
RET |
0.774 | -0.121 | 1 | 0.681 |
HASPIN |
0.774 | -0.025 | -1 | 0.699 |
SRMS |
0.774 | 0.152 | 1 | 0.804 |
OSR1 |
0.773 | -0.111 | 2 | 0.709 |
TAO1 |
0.773 | -0.080 | 1 | 0.612 |
BIKE |
0.773 | -0.024 | 1 | 0.577 |
FER |
0.773 | 0.094 | 1 | 0.808 |
TYK2 |
0.772 | -0.151 | 1 | 0.688 |
EPHB2 |
0.772 | 0.177 | -1 | 0.863 |
MYO3B |
0.772 | -0.084 | 2 | 0.752 |
ROS1 |
0.771 | -0.058 | 3 | 0.731 |
MST1R |
0.771 | -0.120 | 3 | 0.763 |
YES1 |
0.770 | 0.020 | -1 | 0.883 |
DDR1 |
0.770 | -0.096 | 4 | 0.839 |
ABL2 |
0.769 | -0.012 | -1 | 0.851 |
HCK |
0.769 | 0.042 | -1 | 0.849 |
LIMK1_TYR |
0.769 | -0.163 | 2 | 0.799 |
MYO3A |
0.769 | -0.102 | 1 | 0.637 |
CRIK |
0.769 | -0.036 | -3 | 0.666 |
CSF1R |
0.768 | -0.095 | 3 | 0.742 |
TEC |
0.768 | 0.116 | -1 | 0.815 |
BLK |
0.768 | 0.123 | -1 | 0.853 |
ASK1 |
0.768 | -0.180 | 1 | 0.649 |
JAK2 |
0.768 | -0.161 | 1 | 0.682 |
TNK2 |
0.768 | -0.006 | 3 | 0.704 |
LCK |
0.767 | 0.064 | -1 | 0.842 |
EPHA7 |
0.767 | 0.141 | 2 | 0.747 |
INSRR |
0.767 | -0.033 | 3 | 0.706 |
ITK |
0.766 | 0.016 | -1 | 0.828 |
YANK3 |
0.766 | -0.071 | 2 | 0.388 |
FGR |
0.766 | -0.095 | 1 | 0.718 |
ABL1 |
0.765 | -0.034 | -1 | 0.851 |
AXL |
0.765 | -0.011 | 3 | 0.723 |
JAK3 |
0.764 | -0.125 | 1 | 0.679 |
BTK |
0.763 | -0.006 | -1 | 0.820 |
TEK |
0.763 | 0.001 | 3 | 0.686 |
MERTK |
0.762 | 0.013 | 3 | 0.708 |
BMX |
0.762 | 0.025 | -1 | 0.750 |
FLT3 |
0.761 | -0.111 | 3 | 0.745 |
PDGFRB |
0.761 | -0.165 | 3 | 0.767 |
EPHA5 |
0.761 | 0.154 | 2 | 0.741 |
FGFR2 |
0.760 | -0.117 | 3 | 0.742 |
NEK10_TYR |
0.760 | -0.122 | 1 | 0.584 |
FRK |
0.760 | 0.048 | -1 | 0.879 |
JAK1 |
0.759 | -0.106 | 1 | 0.638 |
KIT |
0.759 | -0.129 | 3 | 0.746 |
ALK |
0.759 | -0.035 | 3 | 0.668 |
LTK |
0.759 | -0.033 | 3 | 0.682 |
TNNI3K_TYR |
0.759 | -0.084 | 1 | 0.660 |
EPHA3 |
0.759 | 0.002 | 2 | 0.725 |
PDGFRA |
0.758 | -0.153 | 3 | 0.768 |
EPHA1 |
0.758 | 0.039 | 3 | 0.700 |
PTK6 |
0.758 | -0.063 | -1 | 0.781 |
TNK1 |
0.757 | -0.123 | 3 | 0.730 |
FGFR1 |
0.756 | -0.135 | 3 | 0.711 |
LYN |
0.755 | 0.010 | 3 | 0.667 |
AAK1 |
0.755 | -0.004 | 1 | 0.478 |
STLK3 |
0.755 | -0.222 | 1 | 0.640 |
PTK2B |
0.755 | 0.028 | -1 | 0.845 |
FYN |
0.755 | 0.007 | -1 | 0.808 |
WEE1_TYR |
0.754 | -0.102 | -1 | 0.757 |
KDR |
0.753 | -0.152 | 3 | 0.705 |
NTRK1 |
0.753 | -0.151 | -1 | 0.842 |
CK1A |
0.752 | -0.079 | -3 | 0.408 |
EPHA8 |
0.752 | 0.029 | -1 | 0.828 |
ERBB2 |
0.751 | -0.145 | 1 | 0.662 |
NTRK2 |
0.751 | -0.177 | 3 | 0.714 |
MET |
0.750 | -0.139 | 3 | 0.729 |
FLT1 |
0.750 | -0.129 | -1 | 0.833 |
INSR |
0.749 | -0.140 | 3 | 0.684 |
FGFR3 |
0.747 | -0.145 | 3 | 0.718 |
DDR2 |
0.746 | -0.080 | 3 | 0.691 |
FLT4 |
0.746 | -0.185 | 3 | 0.700 |
EGFR |
0.745 | -0.084 | 1 | 0.598 |
NTRK3 |
0.745 | -0.146 | -1 | 0.794 |
SRC |
0.745 | -0.054 | -1 | 0.831 |
EPHA2 |
0.744 | 0.035 | -1 | 0.790 |
SYK |
0.744 | 0.065 | -1 | 0.749 |
MATK |
0.743 | -0.118 | -1 | 0.770 |
CSK |
0.742 | -0.133 | 2 | 0.746 |
PTK2 |
0.740 | -0.031 | -1 | 0.749 |
FGFR4 |
0.740 | -0.116 | -1 | 0.800 |
CK1G3 |
0.739 | -0.068 | -3 | 0.362 |
MUSK |
0.736 | -0.142 | 1 | 0.583 |
YANK2 |
0.734 | -0.095 | 2 | 0.405 |
IGF1R |
0.733 | -0.142 | 3 | 0.619 |
ERBB4 |
0.732 | -0.067 | 1 | 0.624 |
FES |
0.728 | -0.053 | -1 | 0.738 |
CK1G2 |
0.709 | -0.097 | -3 | 0.454 |
ZAP70 |
0.704 | -0.121 | -1 | 0.647 |