Motif 727 (n=187)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RU67 | FAM234B | S30 | ochoa | Protein FAM234B | None |
| A6NKT7 | RGPD3 | S928 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O00233 | PSMD9 | S127 | ochoa | 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. {ECO:0000269|PubMed:19490896}. |
| O00273 | DFFA | S228 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| O14646 | CHD1 | S367 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14686 | KMT2D | S4814 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14715 | RGPD8 | S927 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O43194 | GPR39 | S427 | ochoa | G-protein coupled receptor 39 | Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466). {ECO:0000250|UniProtKB:Q5U431, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:20522546, ECO:0000269|PubMed:26365466}. |
| O43290 | SART1 | S762 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O43683 | BUB1 | S318 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43688 | PLPP2 | S268 | ochoa | Phospholipid phosphatase 2 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c) | Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:16467304, PubMed:9607309, PubMed:9705349). Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly (PubMed:16467304). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (Probable). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity). {ECO:0000250|UniProtKB:Q8K593, ECO:0000269|PubMed:16467304, ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349, ECO:0000305|PubMed:16467304}. |
| O43719 | HTATSF1 | S485 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O43719 | HTATSF1 | S529 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O60524 | NEMF | S936 | ochoa | Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) | Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:25578875, PubMed:32726578, PubMed:33406423, PubMed:33909987). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:25578875, PubMed:33406423, PubMed:33909987). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (PubMed:25578875). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423, PubMed:33909987). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (PubMed:33406423, PubMed:33909987). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (PubMed:33909987). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (PubMed:33909987). NEMF may also indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000250|UniProtKB:Q12532, ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33406423, ECO:0000269|PubMed:33909987}. |
| O60841 | EIF5B | S295 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75113 | N4BP1 | S300 | ochoa | NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) | Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}. |
| O94880 | PHF14 | S294 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O95232 | LUC7L3 | S395 | ochoa | Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) | Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}. |
| O95721 | SNAP29 | S78 | ochoa | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
| P06241 | FYN | S26 | ochoa | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P0DJD0 | RGPD1 | S912 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S920 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10451 | SPP1 | S291 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11055 | MYH3 | S1777 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | S1780 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1776 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1778 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1779 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13569 | CFTR | S813 | psp | Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) | Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}. |
| P18583 | SON | S278 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P20810 | CAST | S71 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21397 | MAOA | S383 | ochoa | Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) | Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:18391214, PubMed:20493079, PubMed:24169519, PubMed:8316221). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity). {ECO:0000250|UniProtKB:P21396, ECO:0000269|PubMed:18391214, ECO:0000269|PubMed:20493079, ECO:0000269|PubMed:24169519, ECO:0000269|PubMed:8316221}. |
| P22681 | CBL | S705 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P23508 | MCC | S115 | ochoa|psp | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P28290 | ITPRID2 | S380 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29083 | GTF2E1 | S292 | ochoa | General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha) | Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. |
| P30414 | NKTR | S1062 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30419 | NMT1 | S100 | ochoa | Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-) | Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017, PubMed:32111831). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017). {ECO:0000269|PubMed:22865860, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:32111831, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:34999170, ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}. |
| P30533 | LRPAP1 | S247 | ochoa | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}. |
| P30622 | CLIP1 | S1271 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P46087 | NOP2 | S36 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P46100 | ATRX | S108 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S889 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P49792 | RANBP2 | S1903 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50502 | ST13 | S75 | ochoa | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| P50502 | ST13 | S76 | ochoa|psp | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| P52564 | MAP2K6 | S27 | ochoa | Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases. {ECO:0000269|PubMed:10961885, ECO:0000269|PubMed:11727828, ECO:0000269|PubMed:15550393, ECO:0000269|PubMed:20869211, ECO:0000269|PubMed:8622669, ECO:0000269|PubMed:8626699, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9218798}. |
| P52655 | GTF2A1 | S321 | psp | Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] | TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333, ECO:0000269|PubMed:16537915}. |
| P57721 | PCBP3 | S82 | ochoa | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| P60709 | ACTB | S235 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62736 | ACTA2 | S237 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | S235 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S236 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S237 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S237 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P83916 | CBX1 | S129 | ochoa | Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000250|UniProtKB:P83917}. |
| P98082 | DAB2 | S193 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| P98175 | RBM10 | S61 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q00688 | FKBP3 | S100 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| Q00872 | MYBPC1 | S366 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q01484 | ANK2 | S1733 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02224 | CENPE | S2581 | ochoa | Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) | Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}. |
| Q02952 | AKAP12 | S347 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S1512 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q04917 | YWHAH | S145 | ochoa | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Q05682 | CALD1 | S129 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q05682 | CALD1 | S235 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q05682 | CALD1 | S660 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q12789 | GTF3C1 | S1080 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q12931 | TRAP1 | S77 | ochoa | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q12955 | ANK3 | S4325 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13185 | CBX3 | S133 | ochoa | Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}. |
| Q13309 | SKP2 | S48 | ochoa | S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:9736735, PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1 (By similarity). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:9736735, PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731). {ECO:0000250|UniProtKB:Q9Z0Z3, ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|PubMed:16262255, ECO:0000269|PubMed:16581786, ECO:0000269|PubMed:16951159, ECO:0000269|PubMed:17908926, ECO:0000269|PubMed:17962192, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:22770219, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:9736735}.; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. {ECO:0000269|PubMed:27194766}. |
| Q13416 | ORC2 | S139 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13427 | PPIG | S546 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13464 | ROCK1 | S479 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13873 | BMPR2 | S681 | ochoa | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Q14134 | TRIM29 | S58 | ochoa | Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}. |
| Q14191 | WRN | S440 | ochoa|psp | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| Q14653 | IRF3 | S97 | psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14653 | IRF3 | S386 | ochoa|psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14676 | MDC1 | S882 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14677 | CLINT1 | S173 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14739 | LBR | S167 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q14766 | LTBP1 | S787 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q14DG7 | TMEM132B | S793 | ochoa | Transmembrane protein 132B | None |
| Q15365 | PCBP1 | S50 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15366 | PCBP2 | S50 | ochoa | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q2NKX8 | ERCC6L | S1042 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q2PPJ7 | RALGAPA2 | S465 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q4ZHG4 | FNDC1 | S548 | ochoa | Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) | May be an activator of G protein signaling. {ECO:0000250}. |
| Q56P03 | EAPP | S56 | ochoa | E2F-associated phosphoprotein (EAPP) | May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. {ECO:0000269|PubMed:15716352}. |
| Q5H9L2 | TCEAL5 | S142 | ochoa | Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5) | May be involved in transcriptional regulation. |
| Q5JSH3 | WDR44 | S162 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5SW96 | LDLRAP1 | S186 | ochoa|psp | Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein) | Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). {ECO:0000250|UniProtKB:D3ZAR1, ECO:0000269|PubMed:15728179}. |
| Q5T1R4 | HIVEP3 | S805 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T200 | ZC3H13 | S1438 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T7W0 | ZNF618 | S216 | ochoa | Zinc finger protein 618 | Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization. {ECO:0000269|PubMed:27129234}. |
| Q5TC84 | OGFRL1 | S381 | ochoa | Opioid growth factor receptor-like protein 1 | None |
| Q5VT52 | RPRD2 | S817 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VUA4 | ZNF318 | S264 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VV41 | ARHGEF16 | S227 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
| Q5VZ89 | DENND4C | S1606 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q6BDS2 | BLTP3A | S937 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6IPX3 | TCEAL6 | S136 | ochoa | Transcription elongation factor A protein-like 6 (TCEA-like protein 6) (Transcription elongation factor S-II protein-like 6) | May be involved in transcriptional regulation. |
| Q6JBY9 | RCSD1 | S268 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6KC79 | NIPBL | S1090 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6NTE8 | MRNIP | S115 | psp | MRN complex-interacting protein (MRN-interacting protein) | Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553). |
| Q6P0N0 | MIS18BP1 | S175 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P0N0 | MIS18BP1 | S773 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P4E1 | GOLM2 | S374 | ochoa | Protein GOLM2 (Cancer susceptibility candidate gene 4 protein) (CASC4) (Golgi membrane protein 2) | None |
| Q6P995 | FAM171B | S405 | ochoa | Protein FAM171B | None |
| Q6S8J3 | POTEE | S935 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q6UB99 | ANKRD11 | S614 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UXH1 | CRELD2 | S70 | ochoa | Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) | Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698). {ECO:0000250|UniProtKB:Q9CYA0, ECO:0000269|PubMed:16238698}. |
| Q6UXH1 | CRELD2 | S71 | ochoa | Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) | Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698). {ECO:0000250|UniProtKB:Q9CYA0, ECO:0000269|PubMed:16238698}. |
| Q70EL1 | USP54 | S1189 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q7L5D6 | GET4 | S309 | ochoa | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892, ECO:0000269|PubMed:32395830}. |
| Q7L8S5 | OTUD6A | S71 | psp | OTU domain-containing protein 6A (EC 3.4.19.12) (DUBA-2) | Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. {ECO:0000269|PubMed:23827681}. |
| Q7Z3J3 | RGPD4 | S928 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q86T65 | DAAM2 | S1016 | ochoa | Disheveled-associated activator of morphogenesis 2 | Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (PubMed:33232676). {ECO:0000250|UniProtKB:Q80U19, ECO:0000269|PubMed:33232676}. |
| Q8IV38 | ANKMY2 | S403 | ochoa | Ankyrin repeat and MYND domain-containing protein 2 | May be involved in the trafficking of signaling proteins to the cilia. {ECO:0000250}. |
| Q8IV38 | ANKMY2 | S419 | ochoa | Ankyrin repeat and MYND domain-containing protein 2 | May be involved in the trafficking of signaling proteins to the cilia. {ECO:0000250}. |
| Q8IWA0 | WDR75 | S811 | ochoa | WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog) | Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q8IWC1 | MAP7D3 | S751 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IX90 | SKA3 | S334 | ochoa | Spindle and kinetochore-associated protein 3 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}. |
| Q8IZP2 | ST13P4 | S71 | ochoa | Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4) | None |
| Q8IZP2 | ST13P4 | S72 | ochoa | Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4) | None |
| Q8N163 | CCAR2 | S678 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N556 | AFAP1 | S343 | ochoa | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}. |
| Q8ND56 | LSM14A | S347 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NDI1 | EHBP1 | S742 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NI08 | NCOA7 | S596 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TDY2 | RB1CC1 | S1222 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TEA8 | DTD1 | S182 | psp | D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related) | Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}. |
| Q8WUM9 | SLC20A1 | S277 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
| Q92539 | LPIN2 | S187 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q92733 | PRCC | S159 | ochoa | Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) | May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269|PubMed:11717438}. |
| Q969E4 | TCEAL3 | S136 | ochoa | Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) | May be involved in transcriptional regulation. |
| Q96AV8 | E2F7 | S261 | ochoa | Transcription factor E2F7 (E2F-7) | Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269|PubMed:14633988, ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:19223542, ECO:0000269|PubMed:21248772, ECO:0000269|PubMed:22802528, ECO:0000269|PubMed:22802529, ECO:0000269|PubMed:22903062}. |
| Q96PD2 | DCBLD2 | S618 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein) | None |
| Q96Q89 | KIF20B | S442 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96RL1 | UIMC1 | S402 | ochoa|psp | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q99543 | DNAJC2 | S60 | ochoa | DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed] | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. {ECO:0000269|PubMed:15802566, ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}. |
| Q99567 | NUP88 | S442 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q99569 | PKP4 | S83 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99666 | RGPD5 | S927 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BPX3 | NCAPG | S680 | ochoa | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9BTC0 | DIDO1 | S890 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BX63 | BRIP1 | S1106 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BXY4 | RSPO3 | S241 | ochoa | R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) (PubMed:21727895, PubMed:21909076, PubMed:22615920). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720). {ECO:0000250|UniProtKB:Q2TJ95, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:29769720}. |
| Q9BY42 | RTF2 | S214 | ochoa | Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1) | Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q9C0C9 | UBE2O | S839 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9H0E9 | BRD8 | S641 | ochoa | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) | May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q9H2G2 | SLK | S446 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H9B1 | EHMT1 | S38 | ochoa | Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}. |
| Q9NP74 | PALMD | S112 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
| Q9NQW6 | ANLN | S536 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NR99 | MXRA5 | S1305 | ochoa | Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican) | In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. {ECO:0000269|PubMed:27599751}. |
| Q9NWH9 | SLTM | S97 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NZ63 | C9orf78 | S103 | ochoa | Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) | Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}. |
| Q9P2I0 | CPSF2 | S420 | ochoa | Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}. |
| Q9UBU7 | DBF4 | S413 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UKX2 | MYH2 | S1782 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S1780 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UKY1 | ZHX1 | S26 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9UKY1 | ZHX1 | S640 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9ULC3 | RAB23 | S188 | ochoa | Ras-related protein Rab-23 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. {ECO:0000269|PubMed:22365972, ECO:0000269|PubMed:22452336}. |
| Q9ULU4 | ZMYND8 | S655 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UMS6 | SYNPO2 | S519 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9Y2X9 | ZNF281 | S807 | ochoa|psp | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y520 | PRRC2C | S633 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y623 | MYH4 | S1780 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| P33176 | KIF5B | S718 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P05198 | EIF2S1 | S219 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}. |
| Q9UNZ2 | NSFL1C | S205 | Sugiyama | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| P11168 | SLC2A2 | S503 | ELM|iPTMNet|EPSD | Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2) | Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). {ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:23396969, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:3399500, ECO:0000269|PubMed:8027028, ECO:0000269|PubMed:8457197}. |
| P45983 | MAPK8 | S270 | Sugiyama | Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway (PubMed:28943315). In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:18307971). Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins (PubMed:21856198). Loss of this interaction abrogates the acetylation required for replication initiation (PubMed:21856198). Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1 (PubMed:21364637). In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation (PubMed:21095239). Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy (PubMed:18570871). Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons (By similarity). In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (By similarity). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH (PubMed:16581800, PubMed:17296730, PubMed:20027304). Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly (PubMed:22966201). Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity (PubMed:27568560). Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome (PubMed:28943315). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (PubMed:34048572). {ECO:0000250|UniProtKB:P49185, ECO:0000250|UniProtKB:Q91Y86, ECO:0000269|PubMed:10747973, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:18307971, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20027304, ECO:0000269|PubMed:21095239, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:28943315, ECO:0000269|PubMed:34048572}.; FUNCTION: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. |
| P57721 | PCBP3 | S173 | Sugiyama | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| Q04637 | EIF4G1 | S1440 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q15365 | PCBP1 | S141 | Sugiyama | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15366 | PCBP2 | S141 | Sugiyama | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q8IYS1 | PM20D2 | S27 | Sugiyama | Xaa-Arg dipeptidase (EC 3.4.13.4) (Beta-Ala-Lys dipeptidase) | Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. Postulated to function in a metabolite repair mechanism by eliminating alternate dipeptide by-products formed during carnosine synthesis. {ECO:0000269|PubMed:24891507}. |
| Q9UQE7 | SMC3 | S961 | Sugiyama | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
| Q9Y262 | EIF3L | S81 | Sugiyama | Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q9BQ39 | DDX50 | S145 | Sugiyama | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q86WR0 | CCDC25 | S188 | Sugiyama | Coiled-coil domain-containing protein 25 | Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174). {ECO:0000269|PubMed:32528174}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-390522 | Striated Muscle Contraction | 0.000013 | 4.892 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.000008 | 5.082 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.000020 | 4.694 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.000053 | 4.272 |
| R-HSA-1640170 | Cell Cycle | 0.000044 | 4.356 |
| R-HSA-196025 | Formation of annular gap junctions | 0.000379 | 3.422 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.000412 | 3.385 |
| R-HSA-190873 | Gap junction degradation | 0.000487 | 3.312 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.000660 | 3.181 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.000829 | 3.081 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.001245 | 2.905 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.001245 | 2.905 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.001524 | 2.817 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.001633 | 2.787 |
| R-HSA-72172 | mRNA Splicing | 0.002136 | 2.670 |
| R-HSA-69481 | G2/M Checkpoints | 0.002165 | 2.664 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.002842 | 2.546 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.002929 | 2.533 |
| R-HSA-397014 | Muscle contraction | 0.002694 | 2.570 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.002996 | 2.523 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.002996 | 2.523 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.003828 | 2.417 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.004260 | 2.371 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.004027 | 2.395 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.004311 | 2.365 |
| R-HSA-199991 | Membrane Trafficking | 0.004412 | 2.355 |
| R-HSA-68886 | M Phase | 0.004889 | 2.311 |
| R-HSA-68877 | Mitotic Prometaphase | 0.005380 | 2.269 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.005776 | 2.238 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.005776 | 2.238 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.005836 | 2.234 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.006090 | 2.215 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.007073 | 2.150 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.007073 | 2.150 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.008166 | 2.088 |
| R-HSA-983189 | Kinesins | 0.010699 | 1.971 |
| R-HSA-68882 | Mitotic Anaphase | 0.009901 | 2.004 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.010137 | 1.994 |
| R-HSA-418990 | Adherens junctions interactions | 0.010376 | 1.984 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.014029 | 1.853 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.015283 | 1.816 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.016010 | 1.796 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.024536 | 1.610 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.024536 | 1.610 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.024536 | 1.610 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.024536 | 1.610 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.024536 | 1.610 |
| R-HSA-5619098 | Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) | 0.048472 | 1.315 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.060220 | 1.220 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.060220 | 1.220 |
| R-HSA-5579012 | Defective MAOA causes BRUNS | 0.060220 | 1.220 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 0.083286 | 1.079 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.083286 | 1.079 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.105787 | 0.976 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.105787 | 0.976 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.116831 | 0.932 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.127740 | 0.894 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.036395 | 1.439 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.036395 | 1.439 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.039176 | 1.407 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.039176 | 1.407 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.039176 | 1.407 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.039176 | 1.407 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.149155 | 0.826 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.149155 | 0.826 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.170048 | 0.769 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.020189 | 1.695 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.057426 | 1.241 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.021343 | 1.671 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.180302 | 0.744 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.064051 | 1.193 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.070918 | 1.149 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.070918 | 1.149 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.074438 | 1.128 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.200434 | 0.698 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.078012 | 1.108 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.078012 | 1.108 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.210314 | 0.677 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.085318 | 1.069 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.085318 | 1.069 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.089046 | 1.050 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.220073 | 0.657 |
| R-HSA-72649 | Translation initiation complex formation | 0.042887 | 1.368 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.096643 | 1.015 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.229712 | 0.639 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.229712 | 0.639 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.046347 | 1.334 |
| R-HSA-167161 | HIV Transcription Initiation | 0.124537 | 0.905 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.124537 | 0.905 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.267097 | 0.573 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.276158 | 0.559 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.145490 | 0.837 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.063741 | 1.196 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.171491 | 0.766 |
| R-HSA-1221632 | Meiotic synapsis | 0.175898 | 0.755 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.175898 | 0.755 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.102689 | 0.988 |
| R-HSA-3928664 | Ephrin signaling | 0.248636 | 0.604 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.074438 | 1.128 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.080054 | 1.097 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.190430 | 0.720 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.049941 | 1.302 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.141242 | 0.850 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.115664 | 0.937 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.080054 | 1.097 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.116379 | 0.934 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.229878 | 0.639 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.092822 | 1.032 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.124537 | 0.905 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.220073 | 0.657 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.266462 | 0.574 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.132829 | 0.877 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.189222 | 0.723 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.083286 | 1.079 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.031853 | 1.497 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.210314 | 0.677 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.085318 | 1.069 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.229712 | 0.639 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.104416 | 0.981 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.124537 | 0.905 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.276158 | 0.559 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.229712 | 0.639 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.210314 | 0.677 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.089046 | 1.050 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.051788 | 1.286 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.081640 | 1.088 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.025750 | 1.589 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.149155 | 0.826 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.085318 | 1.069 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.073300 | 1.135 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.124537 | 0.905 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.267097 | 0.573 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.076420 | 1.117 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.145490 | 0.837 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.145490 | 0.837 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.145490 | 0.837 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.092822 | 1.032 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.239004 | 0.622 |
| R-HSA-373753 | Nephrin family interactions | 0.267097 | 0.573 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.039333 | 1.405 |
| R-HSA-139910 | Activation of BMF and translocation to mitochondria | 0.060220 | 1.220 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.060220 | 1.220 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.094606 | 1.024 |
| R-HSA-379398 | Enzymatic degradation of Dopamine by monoamine oxidase | 0.138514 | 0.859 |
| R-HSA-380612 | Metabolism of serotonin | 0.149155 | 0.826 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.190430 | 0.720 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.210314 | 0.677 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.092822 | 1.032 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.104416 | 0.981 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.239233 | 0.621 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.248636 | 0.604 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.067716 | 1.169 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.141242 | 0.850 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.171491 | 0.766 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.248147 | 0.605 |
| R-HSA-5693538 | Homology Directed Repair | 0.083544 | 1.078 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.132829 | 0.877 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.063500 | 1.197 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.248636 | 0.604 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.145490 | 0.837 |
| R-HSA-373755 | Semaphorin interactions | 0.220778 | 0.656 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.267097 | 0.573 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.267097 | 0.573 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.138514 | 0.859 |
| R-HSA-141333 | Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB | 0.170048 | 0.769 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.210314 | 0.677 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.089046 | 1.050 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.019048 | 1.720 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.108365 | 0.965 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.267097 | 0.573 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.048127 | 1.318 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.021482 | 1.668 |
| R-HSA-9708530 | Regulation of BACH1 activity | 0.026098 | 1.583 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.248636 | 0.604 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.255394 | 0.593 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.026098 | 1.583 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.266462 | 0.574 |
| R-HSA-8981373 | Intestinal hexose absorption | 0.094606 | 1.024 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.149155 | 0.826 |
| R-HSA-379401 | Dopamine clearance from the synaptic cleft | 0.210314 | 0.677 |
| R-HSA-9664420 | Killing mechanisms | 0.220073 | 0.657 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.220073 | 0.657 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.248636 | 0.604 |
| R-HSA-191859 | snRNP Assembly | 0.202678 | 0.693 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.202678 | 0.693 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.211708 | 0.674 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.188269 | 0.725 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.078012 | 1.108 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.154065 | 0.812 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.257302 | 0.590 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.257302 | 0.590 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.133052 | 0.876 |
| R-HSA-9664407 | Parasite infection | 0.133052 | 0.876 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.133052 | 0.876 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.092822 | 1.032 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.096643 | 1.015 |
| R-HSA-167172 | Transcription of the HIV genome | 0.243573 | 0.613 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.210314 | 0.677 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.112353 | 0.949 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.170048 | 0.769 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.229712 | 0.639 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.056313 | 1.249 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.257924 | 0.589 |
| R-HSA-73886 | Chromosome Maintenance | 0.236280 | 0.627 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 0.048472 | 1.315 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.071824 | 1.144 |
| R-HSA-8866376 | Reelin signalling pathway | 0.083286 | 1.079 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.094606 | 1.024 |
| R-HSA-8964026 | Chylomicron clearance | 0.105787 | 0.976 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.127740 | 0.894 |
| R-HSA-379397 | Enzymatic degradation of dopamine by COMT | 0.149155 | 0.826 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.180302 | 0.744 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.190430 | 0.720 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.220073 | 0.657 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.041207 | 1.385 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.239233 | 0.621 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.116379 | 0.934 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.116379 | 0.934 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.120441 | 0.919 |
| R-HSA-140179 | Amine Oxidase reactions | 0.257924 | 0.589 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.257924 | 0.589 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.220778 | 0.656 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.261881 | 0.582 |
| R-HSA-8953854 | Metabolism of RNA | 0.068774 | 1.163 |
| R-HSA-3371556 | Cellular response to heat stress | 0.027556 | 1.560 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.271042 | 0.567 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.096643 | 1.015 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.120441 | 0.919 |
| R-HSA-9758890 | Transport of RCbl within the body | 0.159666 | 0.797 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.085318 | 1.069 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.229712 | 0.639 |
| R-HSA-450294 | MAP kinase activation | 0.211708 | 0.674 |
| R-HSA-437239 | Recycling pathway of L1 | 0.149765 | 0.825 |
| R-HSA-69206 | G1/S Transition | 0.252749 | 0.597 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.074438 | 1.128 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.185163 | 0.732 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.050611 | 1.296 |
| R-HSA-9007892 | Interleukin-38 signaling | 0.071824 | 1.144 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.083286 | 1.079 |
| R-HSA-164944 | Nef and signal transduction | 0.105787 | 0.976 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.060707 | 1.217 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.190430 | 0.720 |
| R-HSA-190828 | Gap junction trafficking | 0.027646 | 1.558 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.200434 | 0.698 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.210314 | 0.677 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.210314 | 0.677 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.108365 | 0.965 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.145490 | 0.837 |
| R-HSA-448424 | Interleukin-17 signaling | 0.252723 | 0.597 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.261881 | 0.582 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.266462 | 0.574 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.128667 | 0.891 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.185163 | 0.732 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.220073 | 0.657 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.045461 | 1.342 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.092759 | 1.033 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.211708 | 0.674 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.066850 | 1.175 |
| R-HSA-8963676 | Intestinal absorption | 0.127740 | 0.894 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.138514 | 0.859 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.200434 | 0.698 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.034832 | 1.458 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.039562 | 1.403 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.229712 | 0.639 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.112353 | 0.949 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.066850 | 1.175 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.219900 | 0.658 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.059225 | 1.227 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.030273 | 1.519 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.078337 | 1.106 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.043289 | 1.364 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.188269 | 0.725 |
| R-HSA-9675135 | Diseases of DNA repair | 0.145490 | 0.837 |
| R-HSA-68875 | Mitotic Prophase | 0.233010 | 0.633 |
| R-HSA-210990 | PECAM1 interactions | 0.159666 | 0.797 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.200434 | 0.698 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.210314 | 0.677 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.193694 | 0.713 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.216239 | 0.665 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.243573 | 0.613 |
| R-HSA-75153 | Apoptotic execution phase | 0.145490 | 0.837 |
| R-HSA-194138 | Signaling by VEGF | 0.098230 | 1.008 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.095843 | 1.018 |
| R-HSA-162587 | HIV Life Cycle | 0.068605 | 1.164 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.276158 | 0.559 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.276158 | 0.559 |
| R-HSA-373760 | L1CAM interactions | 0.080054 | 1.097 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.154926 | 0.810 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.154926 | 0.810 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.154926 | 0.810 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.190430 | 0.720 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.060711 | 1.217 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.189222 | 0.723 |
| R-HSA-162906 | HIV Infection | 0.089326 | 1.049 |
| R-HSA-74160 | Gene expression (Transcription) | 0.109217 | 0.962 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.191389 | 0.718 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.229748 | 0.639 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.229748 | 0.639 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.239559 | 0.621 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.153276 | 0.815 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.132829 | 0.877 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.239559 | 0.621 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.042036 | 1.376 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.114032 | 0.943 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.246140 | 0.609 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.203997 | 0.690 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.213576 | 0.670 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.023743 | 1.624 |
| R-HSA-9607240 | FLT3 Signaling | 0.120441 | 0.919 |
| R-HSA-109581 | Apoptosis | 0.075298 | 1.123 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.257924 | 0.589 |
| R-HSA-8939211 | ESR-mediated signaling | 0.216791 | 0.664 |
| R-HSA-877300 | Interferon gamma signaling | 0.179448 | 0.746 |
| R-HSA-1500931 | Cell-Cell communication | 0.025573 | 1.592 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.070918 | 1.149 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.248636 | 0.604 |
| R-HSA-913531 | Interferon Signaling | 0.030633 | 1.514 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.227370 | 0.643 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.046347 | 1.334 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.265220 | 0.576 |
| R-HSA-5357801 | Programmed Cell Death | 0.150146 | 0.823 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.138759 | 0.858 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.239233 | 0.621 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.239233 | 0.621 |
| R-HSA-446728 | Cell junction organization | 0.033868 | 1.470 |
| R-HSA-421270 | Cell-cell junction organization | 0.020883 | 1.680 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.083251 | 1.080 |
| R-HSA-196791 | Vitamin D (calciferol) metabolism | 0.248636 | 0.604 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.190430 | 0.720 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.239233 | 0.621 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.271042 | 0.567 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.137021 | 0.863 |
| R-HSA-186712 | Regulation of beta-cell development | 0.202678 | 0.693 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.242846 | 0.615 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.222508 | 0.653 |
| R-HSA-1474244 | Extracellular matrix organization | 0.032450 | 1.489 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.181898 | 0.740 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.280200 | 0.553 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.285107 | 0.545 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.285107 | 0.545 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.285107 | 0.545 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.285107 | 0.545 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.286878 | 0.542 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.289350 | 0.539 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.289350 | 0.539 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.289350 | 0.539 |
| R-HSA-9659379 | Sensory processing of sound | 0.293920 | 0.532 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.293946 | 0.532 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.293946 | 0.532 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.293946 | 0.532 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.293946 | 0.532 |
| R-HSA-189200 | Cellular hexose transport | 0.293946 | 0.532 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 0.293946 | 0.532 |
| R-HSA-8964038 | LDL clearance | 0.293946 | 0.532 |
| R-HSA-9833482 | PKR-mediated signaling | 0.298486 | 0.525 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.302677 | 0.519 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.302677 | 0.519 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.302677 | 0.519 |
| R-HSA-429947 | Deadenylation of mRNA | 0.311300 | 0.507 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.311300 | 0.507 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.311300 | 0.507 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.311300 | 0.507 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.311300 | 0.507 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.311300 | 0.507 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.311300 | 0.507 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.313086 | 0.504 |
| R-HSA-9658195 | Leishmania infection | 0.319726 | 0.495 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.319726 | 0.495 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.319816 | 0.495 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.319816 | 0.495 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.319816 | 0.495 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.319841 | 0.495 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.321237 | 0.493 |
| R-HSA-1500620 | Meiosis | 0.321237 | 0.493 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.328228 | 0.484 |
| R-HSA-70635 | Urea cycle | 0.328228 | 0.484 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.328228 | 0.484 |
| R-HSA-525793 | Myogenesis | 0.328228 | 0.484 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.330290 | 0.481 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.333356 | 0.477 |
| R-HSA-73894 | DNA Repair | 0.334379 | 0.476 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.336537 | 0.473 |
| R-HSA-201451 | Signaling by BMP | 0.336537 | 0.473 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.336537 | 0.473 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.336537 | 0.473 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.336537 | 0.473 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.336537 | 0.473 |
| R-HSA-1483213 | Synthesis of PE | 0.336537 | 0.473 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.336537 | 0.473 |
| R-HSA-264876 | Insulin processing | 0.336537 | 0.473 |
| R-HSA-69242 | S Phase | 0.340111 | 0.468 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.344743 | 0.463 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.349467 | 0.457 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.352848 | 0.452 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.352848 | 0.452 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.352848 | 0.452 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.353606 | 0.451 |
| R-HSA-69306 | DNA Replication | 0.356975 | 0.447 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.360854 | 0.443 |
| R-HSA-2424491 | DAP12 signaling | 0.360854 | 0.443 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.360854 | 0.443 |
| R-HSA-112311 | Neurotransmitter clearance | 0.360854 | 0.443 |
| R-HSA-182971 | EGFR downregulation | 0.368761 | 0.433 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.368761 | 0.433 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.368761 | 0.433 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.368761 | 0.433 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.370859 | 0.431 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.374982 | 0.426 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.376570 | 0.424 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.380484 | 0.420 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.383782 | 0.416 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.384284 | 0.415 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.384284 | 0.415 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.384284 | 0.415 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.384284 | 0.415 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.384284 | 0.415 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.387652 | 0.412 |
| R-HSA-157579 | Telomere Maintenance | 0.388162 | 0.411 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.388162 | 0.411 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.388162 | 0.411 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.391902 | 0.407 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.391902 | 0.407 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.392529 | 0.406 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.396882 | 0.401 |
| R-HSA-3214847 | HATs acetylate histones | 0.396882 | 0.401 |
| R-HSA-212436 | Generic Transcription Pathway | 0.397589 | 0.401 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.399427 | 0.399 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.399427 | 0.399 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.399427 | 0.399 |
| R-HSA-203615 | eNOS activation | 0.399427 | 0.399 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.401220 | 0.397 |
| R-HSA-70171 | Glycolysis | 0.401220 | 0.397 |
| R-HSA-5619102 | SLC transporter disorders | 0.403808 | 0.394 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.405544 | 0.392 |
| R-HSA-422475 | Axon guidance | 0.405782 | 0.392 |
| R-HSA-381042 | PERK regulates gene expression | 0.406859 | 0.391 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.409853 | 0.387 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.409853 | 0.387 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.414200 | 0.383 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.414200 | 0.383 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.414200 | 0.383 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.414200 | 0.383 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.414200 | 0.383 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.421450 | 0.375 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.421450 | 0.375 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.423808 | 0.373 |
| R-HSA-1566948 | Elastic fibre formation | 0.428611 | 0.368 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.428611 | 0.368 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.428611 | 0.368 |
| R-HSA-4839726 | Chromatin organization | 0.429330 | 0.367 |
| R-HSA-69239 | Synthesis of DNA | 0.435377 | 0.361 |
| R-HSA-211000 | Gene Silencing by RNA | 0.435377 | 0.361 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.435683 | 0.361 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.439574 | 0.357 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.442669 | 0.354 |
| R-HSA-9646399 | Aggrephagy | 0.442669 | 0.354 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.442669 | 0.354 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.443754 | 0.353 |
| R-HSA-5688426 | Deubiquitination | 0.445810 | 0.351 |
| R-HSA-162582 | Signal Transduction | 0.447347 | 0.349 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.449568 | 0.347 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.449568 | 0.347 |
| R-HSA-2559583 | Cellular Senescence | 0.449634 | 0.347 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.456189 | 0.341 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.456383 | 0.341 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.456383 | 0.341 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.463113 | 0.334 |
| R-HSA-165159 | MTOR signalling | 0.463113 | 0.334 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.464391 | 0.333 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.467555 | 0.330 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.468465 | 0.329 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.469761 | 0.328 |
| R-HSA-9675108 | Nervous system development | 0.475156 | 0.323 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.476327 | 0.322 |
| R-HSA-2172127 | DAP12 interactions | 0.476327 | 0.322 |
| R-HSA-373752 | Netrin-1 signaling | 0.476327 | 0.322 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.476327 | 0.322 |
| R-HSA-69236 | G1 Phase | 0.476327 | 0.322 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 0.476327 | 0.322 |
| R-HSA-9907900 | Proteasome assembly | 0.476327 | 0.322 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.476556 | 0.322 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.482812 | 0.316 |
| R-HSA-774815 | Nucleosome assembly | 0.482812 | 0.316 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.482812 | 0.316 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.482812 | 0.316 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.482812 | 0.316 |
| R-HSA-70326 | Glucose metabolism | 0.484574 | 0.315 |
| R-HSA-72766 | Translation | 0.487692 | 0.312 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.489217 | 0.310 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.492515 | 0.308 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.495543 | 0.305 |
| R-HSA-1483191 | Synthesis of PC | 0.495543 | 0.305 |
| R-HSA-9609690 | HCMV Early Events | 0.500187 | 0.301 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.501791 | 0.299 |
| R-HSA-9766229 | Degradation of CDH1 | 0.507962 | 0.294 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.517535 | 0.286 |
| R-HSA-2514856 | The phototransduction cascade | 0.520076 | 0.284 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.526022 | 0.279 |
| R-HSA-72187 | mRNA 3'-end processing | 0.526022 | 0.279 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.526022 | 0.279 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.531894 | 0.274 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.531894 | 0.274 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.531894 | 0.274 |
| R-HSA-1474165 | Reproduction | 0.542212 | 0.266 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.543423 | 0.265 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.549081 | 0.260 |
| R-HSA-177929 | Signaling by EGFR | 0.549081 | 0.260 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.549081 | 0.260 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.549554 | 0.260 |
| R-HSA-5621480 | Dectin-2 family | 0.554669 | 0.256 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.560188 | 0.252 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.565639 | 0.247 |
| R-HSA-180786 | Extension of Telomeres | 0.565639 | 0.247 |
| R-HSA-8979227 | Triglyceride metabolism | 0.565639 | 0.247 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.571023 | 0.243 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.571023 | 0.243 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.571023 | 0.243 |
| R-HSA-9679506 | SARS-CoV Infections | 0.576033 | 0.240 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.576340 | 0.239 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.578094 | 0.238 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.581592 | 0.235 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.581592 | 0.235 |
| R-HSA-186797 | Signaling by PDGF | 0.581592 | 0.235 |
| R-HSA-1632852 | Macroautophagy | 0.585021 | 0.233 |
| R-HSA-8848021 | Signaling by PTK6 | 0.586779 | 0.232 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.586779 | 0.232 |
| R-HSA-8963743 | Digestion and absorption | 0.586779 | 0.232 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.586779 | 0.232 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.590878 | 0.229 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.591326 | 0.228 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.591902 | 0.228 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.608602 | 0.216 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.611770 | 0.213 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.621340 | 0.207 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.621340 | 0.207 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.621616 | 0.206 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.624817 | 0.204 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.626037 | 0.203 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.626037 | 0.203 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.630676 | 0.200 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.630676 | 0.200 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.630676 | 0.200 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.631157 | 0.200 |
| R-HSA-73887 | Death Receptor Signaling | 0.631157 | 0.200 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.634296 | 0.198 |
| R-HSA-9612973 | Autophagy | 0.637413 | 0.196 |
| R-HSA-9610379 | HCMV Late Events | 0.640511 | 0.193 |
| R-HSA-2262752 | Cellular responses to stress | 0.643645 | 0.191 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.644251 | 0.191 |
| R-HSA-5689603 | UCH proteinases | 0.648665 | 0.188 |
| R-HSA-9609646 | HCMV Infection | 0.653437 | 0.185 |
| R-HSA-5619084 | ABC transporter disorders | 0.657330 | 0.182 |
| R-HSA-216083 | Integrin cell surface interactions | 0.657330 | 0.182 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.661582 | 0.179 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.661582 | 0.179 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.665782 | 0.177 |
| R-HSA-6806834 | Signaling by MET | 0.665782 | 0.177 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.665782 | 0.177 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.665782 | 0.177 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.665782 | 0.177 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.674027 | 0.171 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.674524 | 0.171 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.675785 | 0.170 |
| R-HSA-72306 | tRNA processing | 0.681712 | 0.166 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.682069 | 0.166 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.689914 | 0.161 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.690025 | 0.161 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.693764 | 0.159 |
| R-HSA-449147 | Signaling by Interleukins | 0.694507 | 0.158 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.697566 | 0.156 |
| R-HSA-9663891 | Selective autophagy | 0.701322 | 0.154 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.701322 | 0.154 |
| R-HSA-168255 | Influenza Infection | 0.706117 | 0.151 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.708694 | 0.150 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.712312 | 0.147 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.715885 | 0.145 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.715885 | 0.145 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.716456 | 0.145 |
| R-HSA-391251 | Protein folding | 0.719414 | 0.143 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.719414 | 0.143 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.722899 | 0.141 |
| R-HSA-2029481 | FCGR activation | 0.722899 | 0.141 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.722899 | 0.141 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.725810 | 0.139 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.726341 | 0.139 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.728950 | 0.137 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.733099 | 0.135 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.733099 | 0.135 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.736415 | 0.133 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.736415 | 0.133 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.738609 | 0.132 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.739974 | 0.131 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.742925 | 0.129 |
| R-HSA-190236 | Signaling by FGFR | 0.742925 | 0.129 |
| R-HSA-422356 | Regulation of insulin secretion | 0.742925 | 0.129 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.753556 | 0.123 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.758508 | 0.120 |
| R-HSA-428157 | Sphingolipid metabolism | 0.759276 | 0.120 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.761483 | 0.118 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.761510 | 0.118 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.761510 | 0.118 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.763673 | 0.117 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.764475 | 0.117 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.764475 | 0.117 |
| R-HSA-9833110 | RSV-host interactions | 0.764475 | 0.117 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.767404 | 0.115 |
| R-HSA-9824446 | Viral Infection Pathways | 0.770739 | 0.113 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.778758 | 0.109 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.786636 | 0.104 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.786911 | 0.104 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.786911 | 0.104 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.786911 | 0.104 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.797318 | 0.098 |
| R-HSA-8951664 | Neddylation | 0.802088 | 0.096 |
| R-HSA-8957322 | Metabolism of steroids | 0.802284 | 0.096 |
| R-HSA-5663205 | Infectious disease | 0.804011 | 0.095 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.804790 | 0.094 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.804790 | 0.094 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.807219 | 0.093 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.818922 | 0.087 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.818922 | 0.087 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.821176 | 0.086 |
| R-HSA-72312 | rRNA processing | 0.821717 | 0.085 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.825601 | 0.083 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.825601 | 0.083 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.825601 | 0.083 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.827772 | 0.082 |
| R-HSA-157118 | Signaling by NOTCH | 0.834882 | 0.078 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.836056 | 0.078 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.836193 | 0.078 |
| R-HSA-163685 | Integration of energy metabolism | 0.851824 | 0.070 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.853670 | 0.069 |
| R-HSA-5368287 | Mitochondrial translation | 0.855494 | 0.068 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.855494 | 0.068 |
| R-HSA-2187338 | Visual phototransduction | 0.872531 | 0.059 |
| R-HSA-166520 | Signaling by NTRKs | 0.874120 | 0.058 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.874340 | 0.058 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.877241 | 0.057 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.877241 | 0.057 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.880003 | 0.056 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.880284 | 0.055 |
| R-HSA-9609507 | Protein localization | 0.881777 | 0.055 |
| R-HSA-9711097 | Cellular response to starvation | 0.888971 | 0.051 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.888971 | 0.051 |
| R-HSA-597592 | Post-translational protein modification | 0.896463 | 0.047 |
| R-HSA-1643685 | Disease | 0.903459 | 0.044 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.905700 | 0.043 |
| R-HSA-418555 | G alpha (s) signalling events | 0.906878 | 0.042 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.906878 | 0.042 |
| R-HSA-195721 | Signaling by WNT | 0.906878 | 0.042 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.909189 | 0.041 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.909189 | 0.041 |
| R-HSA-168256 | Immune System | 0.913331 | 0.039 |
| R-HSA-611105 | Respiratory electron transport | 0.914722 | 0.039 |
| R-HSA-69275 | G2/M Transition | 0.922885 | 0.035 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.924801 | 0.034 |
| R-HSA-109582 | Hemostasis | 0.937589 | 0.028 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.937740 | 0.028 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.937740 | 0.028 |
| R-HSA-1266738 | Developmental Biology | 0.938174 | 0.028 |
| R-HSA-392499 | Metabolism of proteins | 0.939730 | 0.027 |
| R-HSA-6805567 | Keratinization | 0.940799 | 0.027 |
| R-HSA-168249 | Innate Immune System | 0.952431 | 0.021 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.956255 | 0.019 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.959953 | 0.018 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.964570 | 0.016 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.967119 | 0.015 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.968496 | 0.014 |
| R-HSA-416476 | G alpha (q) signalling events | 0.971526 | 0.013 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.974863 | 0.011 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.974909 | 0.011 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.976147 | 0.010 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.980766 | 0.008 |
| R-HSA-1483257 | Phospholipid metabolism | 0.980766 | 0.008 |
| R-HSA-1280218 | Adaptive Immune System | 0.980794 | 0.008 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.982440 | 0.008 |
| R-HSA-6798695 | Neutrophil degranulation | 0.982820 | 0.008 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.986514 | 0.006 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.989269 | 0.005 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.989405 | 0.005 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.991990 | 0.003 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.994603 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 0.995427 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 0.996458 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 0.997396 | 0.001 |
| R-HSA-112316 | Neuronal System | 0.997904 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.998938 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.998965 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999558 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999696 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999889 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999986 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.855 | 0.670 | 2 | 0.912 |
COT |
0.830 | 0.150 | 2 | 0.633 |
MOS |
0.824 | 0.278 | 1 | 0.848 |
CDC7 |
0.821 | 0.149 | 1 | 0.864 |
CLK3 |
0.821 | 0.159 | 1 | 0.725 |
GRK1 |
0.819 | 0.207 | -2 | 0.808 |
CAMK2G |
0.813 | 0.105 | 2 | 0.642 |
DSTYK |
0.812 | 0.087 | 2 | 0.678 |
BMPR1B |
0.812 | 0.221 | 1 | 0.794 |
PRPK |
0.811 | 0.032 | -1 | 0.765 |
PIM3 |
0.807 | 0.011 | -3 | 0.765 |
CAMK2B |
0.805 | 0.186 | 2 | 0.687 |
IKKB |
0.805 | -0.034 | -2 | 0.720 |
BMPR2 |
0.803 | 0.026 | -2 | 0.887 |
GRK6 |
0.802 | 0.078 | 1 | 0.767 |
ALK2 |
0.802 | 0.248 | -2 | 0.848 |
CAMK1B |
0.801 | -0.021 | -3 | 0.811 |
PDHK4 |
0.801 | -0.071 | 1 | 0.735 |
NDR2 |
0.800 | -0.033 | -3 | 0.766 |
ATR |
0.800 | -0.016 | 1 | 0.731 |
RAF1 |
0.800 | -0.085 | 1 | 0.743 |
BMPR1A |
0.800 | 0.222 | 1 | 0.797 |
GCN2 |
0.800 | -0.159 | 2 | 0.551 |
TGFBR1 |
0.799 | 0.141 | -2 | 0.837 |
ATM |
0.799 | 0.078 | 1 | 0.702 |
ACVR2B |
0.798 | 0.178 | -2 | 0.844 |
MTOR |
0.796 | -0.149 | 1 | 0.644 |
TBK1 |
0.796 | -0.088 | 1 | 0.619 |
PIM1 |
0.795 | 0.028 | -3 | 0.723 |
CDKL1 |
0.795 | -0.023 | -3 | 0.736 |
IKKA |
0.795 | -0.005 | -2 | 0.724 |
GRK5 |
0.794 | -0.076 | -3 | 0.818 |
KIS |
0.794 | -0.002 | 1 | 0.542 |
ACVR2A |
0.794 | 0.131 | -2 | 0.841 |
SRPK1 |
0.794 | 0.018 | -3 | 0.672 |
CHAK2 |
0.794 | -0.059 | -1 | 0.735 |
RSK2 |
0.793 | -0.007 | -3 | 0.704 |
TGFBR2 |
0.793 | -0.036 | -2 | 0.847 |
MST4 |
0.793 | -0.036 | 2 | 0.628 |
MLK1 |
0.793 | -0.102 | 2 | 0.581 |
IKKE |
0.793 | -0.088 | 1 | 0.620 |
CK2A2 |
0.793 | 0.185 | 1 | 0.752 |
CAMK2D |
0.793 | 0.040 | -3 | 0.781 |
SKMLCK |
0.792 | 0.006 | -2 | 0.804 |
PKN3 |
0.792 | -0.052 | -3 | 0.762 |
ULK2 |
0.792 | -0.207 | 2 | 0.538 |
MARK4 |
0.792 | -0.023 | 4 | 0.817 |
MAPKAPK2 |
0.792 | 0.034 | -3 | 0.669 |
CAMK2A |
0.792 | 0.066 | 2 | 0.648 |
GRK7 |
0.791 | 0.072 | 1 | 0.679 |
LATS1 |
0.791 | 0.137 | -3 | 0.780 |
ALK4 |
0.791 | 0.049 | -2 | 0.858 |
NIK |
0.791 | -0.106 | -3 | 0.831 |
RIPK3 |
0.791 | -0.088 | 3 | 0.707 |
ERK5 |
0.790 | -0.062 | 1 | 0.675 |
PDHK1 |
0.790 | -0.197 | 1 | 0.725 |
NEK6 |
0.790 | -0.119 | -2 | 0.868 |
GRK4 |
0.790 | -0.046 | -2 | 0.843 |
NLK |
0.790 | -0.121 | 1 | 0.668 |
CDKL5 |
0.789 | -0.018 | -3 | 0.721 |
PRKD1 |
0.789 | -0.039 | -3 | 0.734 |
TSSK2 |
0.788 | -0.002 | -5 | 0.823 |
WNK1 |
0.788 | -0.075 | -2 | 0.822 |
PLK3 |
0.788 | 0.050 | 2 | 0.580 |
NDR1 |
0.788 | -0.071 | -3 | 0.771 |
PRKD2 |
0.788 | -0.024 | -3 | 0.703 |
LATS2 |
0.787 | -0.037 | -5 | 0.732 |
PLK1 |
0.787 | -0.005 | -2 | 0.841 |
CAMLCK |
0.787 | -0.061 | -2 | 0.797 |
BCKDK |
0.786 | -0.113 | -1 | 0.689 |
HUNK |
0.786 | -0.160 | 2 | 0.546 |
CLK2 |
0.786 | 0.079 | -3 | 0.685 |
DAPK2 |
0.786 | -0.075 | -3 | 0.806 |
NEK7 |
0.786 | -0.200 | -3 | 0.794 |
NUAK2 |
0.785 | -0.093 | -3 | 0.779 |
P70S6KB |
0.785 | -0.045 | -3 | 0.739 |
PKCD |
0.784 | -0.069 | 2 | 0.560 |
AMPKA1 |
0.784 | -0.072 | -3 | 0.789 |
DLK |
0.784 | -0.130 | 1 | 0.702 |
MAPKAPK3 |
0.784 | -0.052 | -3 | 0.709 |
TTBK2 |
0.784 | -0.151 | 2 | 0.467 |
CK2A1 |
0.783 | 0.166 | 1 | 0.725 |
ULK1 |
0.783 | -0.203 | -3 | 0.785 |
PKN2 |
0.782 | -0.104 | -3 | 0.776 |
P90RSK |
0.782 | -0.056 | -3 | 0.698 |
HIPK4 |
0.782 | -0.066 | 1 | 0.659 |
RSK4 |
0.782 | 0.009 | -3 | 0.667 |
SRPK2 |
0.782 | -0.001 | -3 | 0.607 |
MLK3 |
0.781 | -0.082 | 2 | 0.536 |
PKR |
0.781 | -0.047 | 1 | 0.726 |
DNAPK |
0.781 | 0.068 | 1 | 0.624 |
RSK3 |
0.780 | -0.064 | -3 | 0.699 |
ANKRD3 |
0.779 | -0.170 | 1 | 0.713 |
TSSK1 |
0.779 | -0.056 | -3 | 0.802 |
AURC |
0.779 | -0.023 | -2 | 0.601 |
ICK |
0.779 | -0.060 | -3 | 0.765 |
MLK4 |
0.779 | -0.083 | 2 | 0.519 |
CDK1 |
0.779 | -0.007 | 1 | 0.489 |
SRPK3 |
0.779 | -0.009 | -3 | 0.655 |
MEK1 |
0.778 | -0.120 | 2 | 0.615 |
WNK3 |
0.777 | -0.247 | 1 | 0.685 |
MLK2 |
0.777 | -0.178 | 2 | 0.581 |
PKACG |
0.777 | -0.066 | -2 | 0.683 |
AMPKA2 |
0.777 | -0.071 | -3 | 0.756 |
MASTL |
0.776 | -0.270 | -2 | 0.792 |
PRKX |
0.776 | 0.030 | -3 | 0.609 |
NEK9 |
0.776 | -0.245 | 2 | 0.569 |
GRK2 |
0.775 | -0.033 | -2 | 0.721 |
PKCB |
0.775 | -0.075 | 2 | 0.518 |
YSK4 |
0.775 | -0.131 | 1 | 0.649 |
PLK2 |
0.774 | 0.093 | -3 | 0.828 |
CDK8 |
0.774 | -0.070 | 1 | 0.503 |
PAK1 |
0.774 | -0.083 | -2 | 0.716 |
CAMK4 |
0.774 | -0.132 | -3 | 0.770 |
RIPK1 |
0.773 | -0.201 | 1 | 0.677 |
PKACB |
0.773 | -0.010 | -2 | 0.612 |
PKCG |
0.772 | -0.099 | 2 | 0.515 |
MSK1 |
0.772 | -0.021 | -3 | 0.676 |
IRE1 |
0.772 | -0.177 | 1 | 0.671 |
MSK2 |
0.772 | -0.069 | -3 | 0.668 |
CLK4 |
0.772 | -0.028 | -3 | 0.703 |
SMG1 |
0.772 | -0.071 | 1 | 0.688 |
CK1E |
0.771 | -0.008 | -3 | 0.521 |
TLK2 |
0.771 | -0.101 | 1 | 0.690 |
NIM1 |
0.771 | -0.160 | 3 | 0.740 |
MYLK4 |
0.771 | -0.046 | -2 | 0.702 |
QSK |
0.771 | -0.074 | 4 | 0.792 |
MARK3 |
0.771 | -0.038 | 4 | 0.749 |
BRSK1 |
0.770 | -0.074 | -3 | 0.728 |
PRKD3 |
0.770 | -0.067 | -3 | 0.675 |
JNK2 |
0.769 | -0.030 | 1 | 0.469 |
AURB |
0.769 | -0.048 | -2 | 0.596 |
CLK1 |
0.769 | -0.031 | -3 | 0.687 |
PKCA |
0.769 | -0.105 | 2 | 0.514 |
CDK5 |
0.769 | -0.041 | 1 | 0.538 |
IRE2 |
0.769 | -0.139 | 2 | 0.501 |
CHK1 |
0.769 | -0.055 | -3 | 0.782 |
MARK2 |
0.768 | -0.046 | 4 | 0.721 |
JNK3 |
0.768 | -0.045 | 1 | 0.508 |
CDK19 |
0.768 | -0.069 | 1 | 0.466 |
VRK2 |
0.768 | -0.300 | 1 | 0.734 |
MEKK3 |
0.768 | -0.119 | 1 | 0.660 |
PERK |
0.768 | -0.126 | -2 | 0.861 |
PKCH |
0.768 | -0.118 | 2 | 0.497 |
BRAF |
0.767 | -0.066 | -4 | 0.797 |
CHAK1 |
0.767 | -0.182 | 2 | 0.506 |
MNK2 |
0.767 | -0.087 | -2 | 0.724 |
AURA |
0.767 | -0.034 | -2 | 0.577 |
PASK |
0.767 | 0.004 | -3 | 0.775 |
NUAK1 |
0.767 | -0.116 | -3 | 0.741 |
DYRK2 |
0.767 | -0.067 | 1 | 0.563 |
MNK1 |
0.766 | -0.073 | -2 | 0.738 |
SIK |
0.766 | -0.088 | -3 | 0.703 |
CAMK1G |
0.766 | -0.071 | -3 | 0.710 |
PAK3 |
0.766 | -0.145 | -2 | 0.708 |
QIK |
0.766 | -0.159 | -3 | 0.775 |
DRAK1 |
0.766 | -0.121 | 1 | 0.646 |
PIM2 |
0.765 | -0.035 | -3 | 0.685 |
MELK |
0.765 | -0.134 | -3 | 0.741 |
CDK2 |
0.765 | -0.039 | 1 | 0.557 |
GRK3 |
0.765 | -0.021 | -2 | 0.686 |
MARK1 |
0.765 | -0.058 | 4 | 0.772 |
TLK1 |
0.765 | -0.107 | -2 | 0.854 |
CDK3 |
0.764 | 0.011 | 1 | 0.428 |
SSTK |
0.763 | -0.023 | 4 | 0.776 |
CK1D |
0.763 | -0.001 | -3 | 0.473 |
CDK7 |
0.763 | -0.089 | 1 | 0.524 |
PKG2 |
0.763 | -0.063 | -2 | 0.615 |
PKCZ |
0.763 | -0.140 | 2 | 0.531 |
NEK2 |
0.763 | -0.216 | 2 | 0.551 |
HRI |
0.763 | -0.173 | -2 | 0.861 |
PHKG1 |
0.763 | -0.157 | -3 | 0.762 |
BRSK2 |
0.762 | -0.130 | -3 | 0.760 |
AKT2 |
0.762 | -0.049 | -3 | 0.625 |
GSK3A |
0.762 | 0.023 | 4 | 0.500 |
P38B |
0.762 | -0.038 | 1 | 0.495 |
PAK6 |
0.762 | -0.083 | -2 | 0.631 |
GSK3B |
0.761 | 0.007 | 4 | 0.488 |
PAK2 |
0.761 | -0.140 | -2 | 0.702 |
PLK4 |
0.761 | -0.165 | 2 | 0.409 |
GAK |
0.760 | -0.025 | 1 | 0.688 |
CDK18 |
0.760 | -0.062 | 1 | 0.450 |
P38A |
0.760 | -0.069 | 1 | 0.546 |
DCAMKL1 |
0.759 | -0.094 | -3 | 0.719 |
CDK13 |
0.759 | -0.096 | 1 | 0.497 |
MST3 |
0.759 | -0.108 | 2 | 0.582 |
MEK5 |
0.758 | -0.283 | 2 | 0.581 |
MAPKAPK5 |
0.758 | -0.117 | -3 | 0.655 |
MEKK2 |
0.758 | -0.184 | 2 | 0.559 |
TTBK1 |
0.758 | -0.160 | 2 | 0.405 |
ZAK |
0.758 | -0.199 | 1 | 0.641 |
EEF2K |
0.757 | -0.036 | 3 | 0.824 |
P38G |
0.757 | -0.060 | 1 | 0.400 |
ERK1 |
0.757 | -0.076 | 1 | 0.474 |
SGK3 |
0.757 | -0.096 | -3 | 0.690 |
SNRK |
0.757 | -0.222 | 2 | 0.442 |
CK1A2 |
0.757 | -0.023 | -3 | 0.472 |
TAO3 |
0.757 | -0.108 | 1 | 0.655 |
DCAMKL2 |
0.757 | -0.102 | -3 | 0.754 |
SMMLCK |
0.756 | -0.084 | -3 | 0.761 |
HIPK2 |
0.756 | -0.054 | 1 | 0.474 |
CAMK1D |
0.756 | -0.027 | -3 | 0.638 |
HIPK1 |
0.756 | -0.069 | 1 | 0.566 |
CDK17 |
0.756 | -0.069 | 1 | 0.407 |
PKACA |
0.755 | -0.032 | -2 | 0.562 |
PRP4 |
0.755 | -0.082 | -3 | 0.668 |
DYRK4 |
0.755 | -0.039 | 1 | 0.488 |
MEKK1 |
0.755 | -0.235 | 1 | 0.665 |
DAPK3 |
0.755 | -0.013 | -3 | 0.737 |
ERK2 |
0.754 | -0.105 | 1 | 0.514 |
NEK5 |
0.754 | -0.223 | 1 | 0.689 |
CAMKK1 |
0.753 | -0.156 | -2 | 0.738 |
ERK7 |
0.753 | -0.063 | 2 | 0.388 |
CK1G1 |
0.753 | -0.083 | -3 | 0.521 |
MST2 |
0.753 | -0.095 | 1 | 0.687 |
ALPHAK3 |
0.752 | 0.168 | -1 | 0.722 |
WNK4 |
0.752 | -0.197 | -2 | 0.816 |
P38D |
0.752 | -0.047 | 1 | 0.426 |
CDK16 |
0.751 | -0.043 | 1 | 0.424 |
GCK |
0.751 | -0.070 | 1 | 0.671 |
PINK1 |
0.751 | -0.238 | 1 | 0.675 |
IRAK4 |
0.750 | -0.206 | 1 | 0.672 |
PHKG2 |
0.750 | -0.132 | -3 | 0.747 |
DYRK1A |
0.750 | -0.088 | 1 | 0.581 |
CDK12 |
0.750 | -0.102 | 1 | 0.470 |
TAO2 |
0.749 | -0.143 | 2 | 0.598 |
PKCT |
0.749 | -0.139 | 2 | 0.503 |
P70S6K |
0.749 | -0.101 | -3 | 0.648 |
TAK1 |
0.749 | -0.119 | 1 | 0.713 |
DAPK1 |
0.748 | -0.030 | -3 | 0.715 |
NEK8 |
0.748 | -0.232 | 2 | 0.553 |
TNIK |
0.748 | -0.065 | 3 | 0.837 |
MPSK1 |
0.748 | -0.113 | 1 | 0.626 |
NEK11 |
0.747 | -0.233 | 1 | 0.649 |
CAMKK2 |
0.747 | -0.169 | -2 | 0.726 |
JNK1 |
0.747 | -0.054 | 1 | 0.466 |
CDK9 |
0.747 | -0.123 | 1 | 0.500 |
PKCE |
0.747 | -0.081 | 2 | 0.503 |
CDK10 |
0.746 | -0.061 | 1 | 0.473 |
AKT1 |
0.746 | -0.074 | -3 | 0.640 |
MINK |
0.745 | -0.094 | 1 | 0.665 |
CDK14 |
0.745 | -0.092 | 1 | 0.484 |
IRAK1 |
0.744 | -0.215 | -1 | 0.646 |
PKCI |
0.744 | -0.136 | 2 | 0.515 |
EPHA6 |
0.744 | 0.227 | -1 | 0.856 |
HIPK3 |
0.744 | -0.118 | 1 | 0.550 |
DYRK1B |
0.744 | -0.081 | 1 | 0.500 |
PDHK3_TYR |
0.744 | 0.157 | 4 | 0.892 |
LKB1 |
0.743 | -0.184 | -3 | 0.775 |
MST1 |
0.743 | -0.127 | 1 | 0.666 |
HGK |
0.743 | -0.125 | 3 | 0.826 |
HPK1 |
0.742 | -0.090 | 1 | 0.661 |
DYRK3 |
0.742 | -0.086 | 1 | 0.573 |
PDK1 |
0.741 | -0.187 | 1 | 0.661 |
LRRK2 |
0.740 | -0.217 | 2 | 0.582 |
TTK |
0.740 | -0.008 | -2 | 0.864 |
VRK1 |
0.739 | -0.211 | 2 | 0.558 |
BMPR2_TYR |
0.738 | 0.171 | -1 | 0.840 |
ROCK2 |
0.738 | -0.047 | -3 | 0.717 |
SLK |
0.738 | -0.121 | -2 | 0.689 |
NEK4 |
0.738 | -0.238 | 1 | 0.660 |
KHS2 |
0.738 | -0.049 | 1 | 0.670 |
MRCKA |
0.738 | -0.056 | -3 | 0.703 |
MRCKB |
0.737 | -0.059 | -3 | 0.680 |
SGK1 |
0.737 | -0.048 | -3 | 0.544 |
EPHA4 |
0.737 | 0.188 | 2 | 0.597 |
STK33 |
0.737 | -0.175 | 2 | 0.421 |
KHS1 |
0.737 | -0.080 | 1 | 0.663 |
PDHK4_TYR |
0.737 | 0.110 | 2 | 0.645 |
LOK |
0.737 | -0.153 | -2 | 0.725 |
PAK5 |
0.736 | -0.127 | -2 | 0.576 |
MAP3K15 |
0.736 | -0.227 | 1 | 0.618 |
MAP2K6_TYR |
0.735 | 0.111 | -1 | 0.782 |
AKT3 |
0.735 | -0.056 | -3 | 0.554 |
PAK4 |
0.735 | -0.114 | -2 | 0.586 |
TXK |
0.735 | 0.178 | 1 | 0.769 |
OSR1 |
0.735 | -0.095 | 2 | 0.568 |
MEKK6 |
0.734 | -0.251 | 1 | 0.651 |
NEK1 |
0.734 | -0.235 | 1 | 0.663 |
CAMK1A |
0.734 | -0.074 | -3 | 0.599 |
YANK3 |
0.733 | -0.068 | 2 | 0.295 |
MAK |
0.733 | -0.019 | -2 | 0.723 |
PDHK1_TYR |
0.733 | 0.080 | -1 | 0.813 |
EPHB4 |
0.733 | 0.116 | -1 | 0.803 |
DMPK1 |
0.733 | -0.022 | -3 | 0.710 |
CHK2 |
0.732 | -0.100 | -3 | 0.577 |
PKN1 |
0.732 | -0.133 | -3 | 0.665 |
MOK |
0.732 | -0.042 | 1 | 0.595 |
BUB1 |
0.732 | -0.067 | -5 | 0.753 |
SBK |
0.731 | -0.035 | -3 | 0.519 |
TESK1_TYR |
0.731 | -0.039 | 3 | 0.839 |
MAP2K4_TYR |
0.731 | -0.015 | -1 | 0.773 |
CDK6 |
0.731 | -0.091 | 1 | 0.460 |
MEK2 |
0.731 | -0.266 | 2 | 0.566 |
YSK1 |
0.729 | -0.200 | 2 | 0.554 |
SRMS |
0.727 | 0.155 | 1 | 0.791 |
BLK |
0.727 | 0.177 | -1 | 0.835 |
EPHB2 |
0.727 | 0.155 | -1 | 0.795 |
PBK |
0.727 | -0.128 | 1 | 0.610 |
MAP2K7_TYR |
0.727 | -0.150 | 2 | 0.616 |
CDK4 |
0.726 | -0.099 | 1 | 0.461 |
HASPIN |
0.725 | -0.071 | -1 | 0.594 |
RIPK2 |
0.725 | -0.280 | 1 | 0.602 |
EPHB3 |
0.725 | 0.116 | -1 | 0.798 |
FER |
0.725 | 0.076 | 1 | 0.803 |
CK1A |
0.725 | -0.048 | -3 | 0.388 |
PINK1_TYR |
0.724 | -0.126 | 1 | 0.713 |
EPHB1 |
0.724 | 0.085 | 1 | 0.773 |
FYN |
0.724 | 0.189 | -1 | 0.843 |
LCK |
0.724 | 0.138 | -1 | 0.834 |
EPHA7 |
0.724 | 0.132 | 2 | 0.584 |
INSRR |
0.724 | 0.092 | 3 | 0.708 |
PTK2 |
0.723 | 0.172 | -1 | 0.848 |
PKMYT1_TYR |
0.723 | -0.154 | 3 | 0.798 |
ROCK1 |
0.722 | -0.069 | -3 | 0.694 |
EPHA5 |
0.722 | 0.177 | 2 | 0.595 |
HCK |
0.722 | 0.102 | -1 | 0.812 |
YES1 |
0.720 | 0.044 | -1 | 0.782 |
ABL2 |
0.720 | 0.024 | -1 | 0.748 |
SYK |
0.720 | 0.198 | -1 | 0.820 |
BIKE |
0.720 | -0.071 | 1 | 0.560 |
CRIK |
0.720 | -0.056 | -3 | 0.638 |
RET |
0.718 | -0.104 | 1 | 0.667 |
LIMK2_TYR |
0.718 | -0.126 | -3 | 0.837 |
BMX |
0.718 | 0.052 | -1 | 0.719 |
PKG1 |
0.717 | -0.110 | -2 | 0.528 |
EPHA8 |
0.717 | 0.123 | -1 | 0.832 |
EPHA3 |
0.717 | 0.046 | 2 | 0.559 |
MYO3A |
0.717 | -0.154 | 1 | 0.662 |
MYO3B |
0.717 | -0.165 | 2 | 0.572 |
ITK |
0.717 | 0.022 | -1 | 0.763 |
DDR1 |
0.715 | -0.072 | 4 | 0.790 |
TEC |
0.715 | 0.030 | -1 | 0.707 |
MST1R |
0.715 | -0.128 | 3 | 0.765 |
TYRO3 |
0.715 | -0.108 | 3 | 0.751 |
TYK2 |
0.715 | -0.166 | 1 | 0.672 |
JAK3 |
0.715 | -0.043 | 1 | 0.648 |
ASK1 |
0.714 | -0.230 | 1 | 0.613 |
CSF1R |
0.714 | -0.073 | 3 | 0.740 |
NEK3 |
0.714 | -0.273 | 1 | 0.605 |
FGR |
0.713 | -0.063 | 1 | 0.715 |
FGFR2 |
0.713 | -0.020 | 3 | 0.757 |
ROS1 |
0.713 | -0.135 | 3 | 0.722 |
ABL1 |
0.712 | -0.030 | -1 | 0.738 |
LIMK1_TYR |
0.711 | -0.229 | 2 | 0.604 |
STLK3 |
0.711 | -0.193 | 1 | 0.613 |
KIT |
0.711 | -0.047 | 3 | 0.744 |
LYN |
0.711 | 0.087 | 3 | 0.656 |
JAK2 |
0.710 | -0.154 | 1 | 0.661 |
MERTK |
0.710 | -0.017 | 3 | 0.719 |
TAO1 |
0.710 | -0.191 | 1 | 0.586 |
TNK2 |
0.709 | -0.068 | 3 | 0.709 |
EPHA2 |
0.709 | 0.116 | -1 | 0.795 |
TEK |
0.708 | -0.046 | 3 | 0.686 |
FRK |
0.708 | 0.017 | -1 | 0.819 |
BTK |
0.707 | -0.052 | -1 | 0.708 |
EGFR |
0.707 | 0.030 | 1 | 0.559 |
MET |
0.707 | -0.036 | 3 | 0.736 |
FLT1 |
0.707 | -0.033 | -1 | 0.807 |
EPHA1 |
0.707 | 0.009 | 3 | 0.716 |
FLT3 |
0.706 | -0.107 | 3 | 0.739 |
LTK |
0.706 | -0.053 | 3 | 0.692 |
PTK2B |
0.705 | 0.007 | -1 | 0.724 |
ERBB2 |
0.705 | -0.051 | 1 | 0.644 |
AXL |
0.705 | -0.078 | 3 | 0.730 |
FGFR3 |
0.705 | -0.026 | 3 | 0.735 |
KDR |
0.704 | -0.102 | 3 | 0.715 |
SRC |
0.704 | 0.047 | -1 | 0.810 |
PDGFRB |
0.703 | -0.167 | 3 | 0.761 |
ALK |
0.703 | -0.087 | 3 | 0.673 |
CK1G3 |
0.702 | -0.056 | -3 | 0.341 |
ERBB4 |
0.701 | 0.068 | 1 | 0.612 |
NTRK1 |
0.701 | -0.086 | -1 | 0.736 |
FGFR1 |
0.701 | -0.121 | 3 | 0.722 |
PTK6 |
0.701 | -0.148 | -1 | 0.674 |
YANK2 |
0.701 | -0.081 | 2 | 0.326 |
WEE1_TYR |
0.699 | -0.128 | -1 | 0.678 |
AAK1 |
0.699 | -0.056 | 1 | 0.457 |
INSR |
0.699 | -0.062 | 3 | 0.678 |
JAK1 |
0.699 | -0.145 | 1 | 0.607 |
NEK10_TYR |
0.698 | -0.165 | 1 | 0.548 |
CK1G2 |
0.698 | -0.007 | -3 | 0.439 |
PDGFRA |
0.696 | -0.217 | 3 | 0.761 |
FGFR4 |
0.696 | -0.013 | -1 | 0.723 |
FLT4 |
0.696 | -0.133 | 3 | 0.701 |
CSK |
0.695 | -0.064 | 2 | 0.570 |
MATK |
0.694 | -0.090 | -1 | 0.677 |
TNNI3K_TYR |
0.694 | -0.180 | 1 | 0.683 |
DDR2 |
0.694 | -0.020 | 3 | 0.701 |
NTRK3 |
0.693 | -0.094 | -1 | 0.703 |
TNK1 |
0.692 | -0.211 | 3 | 0.722 |
NTRK2 |
0.692 | -0.168 | 3 | 0.708 |
IGF1R |
0.691 | -0.030 | 3 | 0.617 |
ZAP70 |
0.681 | 0.017 | -1 | 0.732 |
FES |
0.680 | -0.056 | -1 | 0.692 |
MUSK |
0.677 | -0.160 | 1 | 0.536 |