Motif 726 (n=170)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | Y150 | ochoa | Golgin A8 family member Q | None |
| A6NI79 | CCDC69 | S241 | ochoa | Coiled-coil domain-containing protein 69 | May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone. {ECO:0000305|PubMed:20962590}. |
| I6L899 | GOLGA8R | Y150 | ochoa | Golgin subfamily A member 8R | None |
| O14818 | PSMA7 | S201 | ochoa | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O15400 | STX7 | S81 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O15400 | STX7 | S147 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O60566 | BUB1B | S714 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O75146 | HIP1R | S592 | ochoa | Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) | Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}. |
| O75154 | RAB11FIP3 | S488 | psp | Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148) | Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867). {ECO:0000250|UniProtKB:Q8CHD8, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:17628206, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19327867, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26258637, ECO:0000269|PubMed:31204173}. |
| O75348 | ATP6V1G1 | S68 | ochoa | V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}. |
| O75934 | BCAS2 | S94 | ochoa | Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27) | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30705154}. |
| O95235 | KIF20A | S635 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95239 | KIF4A | S548 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95400 | CD2BP2 | S146 | ochoa | CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}. |
| P01834 | IGKC | S52 | ochoa | Immunoglobulin kappa constant (Ig kappa chain C region) (Ig kappa chain C region AG) (Ig kappa chain C region CUM) (Ig kappa chain C region EU) (Ig kappa chain C region OU) (Ig kappa chain C region ROY) (Ig kappa chain C region TI) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P02042 | HBD | S87 | ochoa | Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain) | Involved in oxygen transport from the lung to the various peripheral tissues. |
| P02545 | LMNA | S107 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02545 | LMNA | S307 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P05549 | TFAP2A | S225 | ochoa | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
| P09874 | PARP1 | S179 | ochoa|psp | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P11532 | DMD | S3490 | ochoa|psp | Dystrophin | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}. |
| P12882 | MYH1 | S1261 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1303 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1574 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | T1855 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1102 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1299 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1630 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T1851 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13010 | XRCC5 | S145 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13533 | MYH6 | S1301 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1632 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1573 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13535 | MYH8 | T1854 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P15822 | HIVEP1 | S1048 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P20273 | CD22 | S726 | ochoa | B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) | Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow (PubMed:34330755, PubMed:8627166). Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration (PubMed:20172905). Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling (PubMed:8627166). If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced (PubMed:20516366). {ECO:0000269|PubMed:20172905, ECO:0000269|PubMed:20516366, ECO:0000269|PubMed:34330755, ECO:0000269|PubMed:8627166}. |
| P20290 | BTF3 | S149 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
| P20700 | LMNB1 | S58 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P20700 | LMNB1 | S308 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P23258 | TUBG1 | S385 | psp | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:38609661, PubMed:39321809). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P25101 | EDNRA | S295 | psp | Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) | Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
| P31327 | CPS1 | S1021 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P32298 | GRK4 | S244 | psp | G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}. |
| P33527 | ABCC1 | S961 | psp | Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) | Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231). {ECO:0000250|UniProtKB:O35379, ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:9281595, ECO:0000269|PubMed:9426231}. |
| P35579 | MYH9 | S1803 | psp | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35609 | ACTN2 | S431 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35749 | MYH11 | S1374 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P39748 | FEN1 | S210 | ochoa | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
| P40337 | VHL | S168 | psp | von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272). {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:34290272}. |
| P46940 | IQGAP1 | S1151 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P49790 | NUP153 | S320 | ochoa|psp | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P50454 | SERPINH1 | S265 | ochoa | Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) | Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. |
| P50748 | KNTC1 | S1050 | ochoa | Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| P51531 | SMARCA2 | S1410 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P52630 | STAT2 | S287 | psp | Signal transducer and activator of transcription 2 (p113) | Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}. |
| P52732 | KIF11 | S931 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P68363 | TUBA1B | S232 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S232 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78347 | GTF2I | S453 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P78524 | DENND2B | S673 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| P98175 | RBM10 | S781 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q01850 | CDR2 | S189 | ochoa | Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen) | None |
| Q03252 | LMNB2 | S322 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q12767 | TMEM94 | S454 | ochoa | Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase) | Could function in the uptake of Mg(2+) from the cytosol into the endoplasmic reticulum and regulate intracellular Mg(2+) homeostasis. {ECO:0000269|PubMed:38513662}. |
| Q12802 | AKAP13 | S2567 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13103 | SPP2 | S170 | ochoa | Secreted phosphoprotein 24 (Spp-24) (Secreted phosphoprotein 2) | Could coordinate an aspect of bone turnover. {ECO:0000250}. |
| Q13137 | CALCOCO2 | S238 | ochoa | Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52) | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:25771791}. |
| Q13164 | MAPK7 | S731 | ochoa|psp | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q13439 | GOLGA4 | S1514 | ochoa | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| Q13501 | SQSTM1 | S361 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13772 | NCOA4 | S554 | ochoa | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) | Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}. |
| Q13813 | SPTAN1 | S1226 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14008 | CKAP5 | S2004 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14161 | GIT2 | S421 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14315 | FLNC | S1972 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14324 | MYBPC2 | S300 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14643 | ITPR1 | S2696 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000250|UniProtKB:P29994, ECO:0000269|PubMed:10620513, ECO:0000269|PubMed:27108797}. |
| Q14789 | GOLGB1 | S543 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14789 | GOLGB1 | S560 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14789 | GOLGB1 | S3056 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15025 | TNIP1 | S403 | ochoa | TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) | Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814, ECO:0000269|PubMed:21885437}. |
| Q15029 | EFTUD2 | S948 | ochoa | 116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa) | Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:25092792, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:25092792, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000305|PubMed:33509932}. |
| Q16206 | ENOX2 | S504 | psp | Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] | May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:12356293, ECO:0000269|PubMed:9932650}. |
| Q16799 | RTN1 | S166 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q4KMP7 | TBC1D10B | S633 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q4VCS5 | AMOT | S538 | psp | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q53GL7 | PARP10 | S143 | ochoa | Protein mono-ADP-ribosyltransferase PARP10 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) (Poly [ADP-ribose] polymerase 10) (PARP-10) | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737). {ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:23332125, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:24695737, ECO:0000269|PubMed:25043379}. |
| Q58WW2 | DCAF6 | S592 | ochoa | DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) | Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
| Q6PCB8 | EMB | S309 | ochoa | Embigin | Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane (By similarity). {ECO:0000250|UniProtKB:O88775}. |
| Q6UWE0 | LRSAM1 | S290 | ochoa | E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}. |
| Q6VMQ6 | ATF7IP | S429 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6VUC0 | TFAP2E | S232 | ochoa | Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}. |
| Q6ZP65 | BICDL1 | S270 | ochoa | BICD family-like cargo adapter 1 (Bicaudal D-related protein 1) (BICD-related protein 1) (BICDR-1) (Coiled-coil domain-containing protein 64A) (CCDC64A) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis. {ECO:0000250|UniProtKB:A0JNT9}. |
| Q6ZU35 | CRACD | S1072 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZU80 | CEP128 | S331 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q6ZU80 | CEP128 | S797 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q7Z3B3 | KANSL1 | S115 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z6R9 | TFAP2D | S225 | ochoa | Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). {ECO:0000250}. |
| Q86TV6 | TTC7B | S202 | ochoa | Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:26571211}. |
| Q8IZ21 | PHACTR4 | S449 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8N0Z3 | SPICE1 | S680 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8N5G2 | MACO1 | S227 | ochoa | Macoilin (Macoilin-1) (Transmembrane protein 57) | Plays a role in the regulation of neuronal activity. {ECO:0000269|PubMed:21589894}. |
| Q8NCF5 | NFATC2IP | S345 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NEB9 | PIK3C3 | S455 | ochoa | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8NER1 | TRPV1 | S117 | psp | Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) | Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:11050376, PubMed:11243859, PubMed:11226139, PubMed:12077606). Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activated by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius (PubMed:37117175). Upon activation, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. {ECO:0000250|UniProtKB:O35433, ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11226139, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:37117175}. |
| Q8NFH8 | REPS2 | S631 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8NFZ8 | CADM4 | S354 | ochoa | Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2) | Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity. {ECO:0000269|PubMed:16261159}. |
| Q8TAA3 | PSMA8 | S209 | ochoa | Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like) | Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. {ECO:0000250|UniProtKB:Q9CWH6}. |
| Q8TD16 | BICD2 | S224 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TD16 | BICD2 | S486 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TD43 | TRPM4 | S1152 | psp | Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) | Calcium-activated selective cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:12842017, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:12015988). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822). {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:12842017, ECO:0000269|PubMed:14758478, ECO:0000269|PubMed:15121803, ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:15550671, ECO:0000269|PubMed:15590641, ECO:0000269|PubMed:15845551, ECO:0000269|PubMed:16186107, ECO:0000269|PubMed:16407466, ECO:0000269|PubMed:16424899, ECO:0000269|PubMed:16806463, ECO:0000269|PubMed:20625999, ECO:0000269|PubMed:20656926, ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:30528822}.; FUNCTION: [Isoform 2]: Lacks channel activity. {ECO:0000269|PubMed:12842017}. |
| Q8TDY2 | RB1CC1 | S222 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TE99 | PXYLP1 | S387 | ochoa | 2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) (Xylosyl phosphatase) (epididymis luminal protein 124) | Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. {ECO:0000269|PubMed:24425863}. |
| Q92481 | TFAP2B | S244 | ochoa | Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}. |
| Q92754 | TFAP2C | S238 | ochoa | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}. |
| Q96BY6 | DOCK10 | S1322 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96CN4 | EVI5L | S685 | ochoa | EVI5-like protein (Ecotropic viral integration site 5-like protein) | Functions as a GTPase-activating protein (GAP) with a broad specificity. {ECO:0000269|PubMed:16923123}. |
| Q96D71 | REPS1 | S767 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96MT3 | PRICKLE1 | S600 | ochoa | Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1) | Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}. |
| Q96Q42 | ALS2 | S489 | ochoa | Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) | May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}. |
| Q96SN8 | CDK5RAP2 | S1389 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q96T51 | RUFY1 | S620 | ochoa | RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) | Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity). {ECO:0000250|UniProtKB:Q8BIJ7, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}. |
| Q99550 | MPHOSPH9 | S1137 | ochoa | M-phase phosphoprotein 9 | Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}. |
| Q9BPX3 | NCAPG | S680 | ochoa | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9BQE3 | TUBA1C | S232 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BRA0 | NAA38 | S29 | ochoa | N-alpha-acetyltransferase 38, NatC auxiliary subunit (LSM domain-containing protein 1) (Phosphonoformate immuno-associated protein 2) | Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q9BRP8 | PYM1 | S177 | ochoa | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}. |
| Q9BV73 | CEP250 | S1295 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BW19 | KIFC1 | S26 | ochoa|psp | Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET) | Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9QWT9, ECO:0000269|PubMed:15843429}. |
| Q9BY77 | POLDIP3 | S42 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9BYX2 | TBC1D2 | S295 | ochoa | TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) | Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}. |
| Q9H5N1 | RABEP2 | S27 | ochoa | Rab GTPase-binding effector protein 2 (Rabaptin-5beta) | Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062). {ECO:0000269|PubMed:27224062, ECO:0000269|PubMed:29425100, ECO:0000269|PubMed:9524116}. |
| Q9H853 | TUBA4B | S171 | ochoa | Tubulin-like protein alpha-4B (EC 3.6.5.-) (Alpha-tubulin 4B) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed ofalpha- and beta-tubulin heterodimers. {ECO:0000250|UniProtKB:P68363}. |
| Q9H967 | WDR76 | S114 | ochoa | WD repeat-containing protein 76 | Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000250}. |
| Q9NS87 | KIF15 | S378 | ochoa | Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) | Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}. |
| Q9NY65 | TUBA8 | S232 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9NYL2 | MAP3K20 | S302 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9P1W3 | TMEM63C | S77 | ochoa | Osmosensitive cation channel TMEM63C (Calcium permeable stress-gated cation channel 1) (Transmembrane protein 63C) (hTMEM63C) | Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress (PubMed:24503647, PubMed:35718349). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles' morphologies in response to osmotic changes (PubMed:35718349). In particular may regulate mitochondrial motility and function in motor neuron axons (PubMed:35718349). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). {ECO:0000250|UniProtKB:D3ZNF5, ECO:0000269|PubMed:24503647, ECO:0000269|PubMed:35718349, ECO:0000269|PubMed:39716028}. |
| Q9UBB4 | ATXN10 | S430 | ochoa | Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein) | May play a role in the regulation of cytokinesis (PubMed:21857149, PubMed:25666058). May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons (By similarity). Does not appear to play a major role in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:P28658, ECO:0000250|UniProtKB:Q9ER24, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:25666058}. |
| Q9UKV3 | ACIN1 | S125 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKV3 | ACIN1 | S132 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKV3 | ACIN1 | S1232 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKX2 | MYH2 | S1305 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1576 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T1857 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UL54 | TAOK2 | S493 | ochoa | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
| Q9ULT0 | TTC7A | S690 | ochoa | Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. |
| Q9UPT5 | EXOC7 | S283 | ochoa | Exocyst complex component 7 (Exocyst complex component Exo70) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). It is required for neuron survival and plays an essential role in cortical development (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:E7FC72}. |
| Q9UQE7 | SMC3 | S787 | ochoa|psp | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
| Q9Y2X7 | GIT1 | S448 | psp | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y490 | TLN1 | S834 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4D7 | PLXND1 | S1316 | ochoa | Plexin-D1 | Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. {ECO:0000250, ECO:0000269|PubMed:20385769}. |
| Q9Y623 | MYH4 | T1855 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| O60231 | DHX16 | S319 | Sugiyama | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) | Required for pre-mRNA splicing as a component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596). {ECO:0000269|PubMed:20423332, ECO:0000269|PubMed:20841358, ECO:0000269|PubMed:25296192, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:35263596, ECO:0000305|PubMed:33509932}. |
| Q9Y262 | EIF3L | S249 | Sugiyama | Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q05397 | PTK2 | S677 | Sugiyama | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| P33176 | KIF5B | S717 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| O60925 | PFDN1 | S78 | Sugiyama | Prefoldin subunit 1 | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. |
| P51957 | NEK4 | S58 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P18887 | XRCC1 | S578 | PSP | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P26358 | DNMT1 | S91 | Sugiyama | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| Q15208 | STK38 | S32 | Sugiyama | Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488). {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:32537488, ECO:0000269|PubMed:7761441}. |
| Q13464 | ROCK1 | S482 | Sugiyama | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13464 | ROCK1 | S576 | Sugiyama | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q8TBC4 | UBA3 | S420 | Sugiyama | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) | Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}. |
| Q8WUM4 | PDCD6IP | S557 | Sugiyama | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. |
| Q16654 | PDK4 | S45 | Sugiyama | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. {ECO:0000269|PubMed:15955060, ECO:0000269|PubMed:18658136, ECO:0000269|PubMed:21816445, ECO:0000269|PubMed:21852536}. |
| P08758 | ANXA5 | S46 | Sugiyama | Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
| Q96R06 | SPAG5 | S716 | Sugiyama | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q00610 | CLTC | S432 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-983189 | Kinesins | 2.433909e-11 | 10.614 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 3.727503e-09 | 8.429 |
| R-HSA-68886 | M Phase | 5.524594e-09 | 8.258 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.130408e-09 | 8.213 |
| R-HSA-199991 | Membrane Trafficking | 1.648096e-09 | 8.783 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.149401e-09 | 8.211 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.869620e-09 | 8.412 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.506755e-08 | 7.822 |
| R-HSA-68877 | Mitotic Prometaphase | 1.960712e-08 | 7.708 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.985991e-08 | 7.525 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.162954e-08 | 7.381 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.707063e-07 | 6.768 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 2.904583e-07 | 6.537 |
| R-HSA-68882 | Mitotic Anaphase | 4.854375e-07 | 6.314 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.101588e-07 | 6.292 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.909311e-07 | 6.161 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.250038e-06 | 5.488 |
| R-HSA-437239 | Recycling pathway of L1 | 3.246973e-06 | 5.489 |
| R-HSA-69275 | G2/M Transition | 3.728095e-06 | 5.429 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.109919e-06 | 5.386 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.258376e-06 | 5.371 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.951999e-06 | 5.305 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 5.502328e-06 | 5.259 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 6.810867e-06 | 5.167 |
| R-HSA-2467813 | Separation of Sister Chromatids | 7.096060e-06 | 5.149 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.440123e-06 | 5.128 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.015140e-05 | 4.993 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 9.832715e-06 | 5.007 |
| R-HSA-1640170 | Cell Cycle | 2.110233e-05 | 4.676 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.059651e-05 | 4.686 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.416038e-05 | 4.617 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.862839e-05 | 4.543 |
| R-HSA-190828 | Gap junction trafficking | 2.862839e-05 | 4.543 |
| R-HSA-75153 | Apoptotic execution phase | 3.525729e-05 | 4.453 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.838347e-05 | 4.416 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.359578e-05 | 4.361 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.745747e-05 | 4.324 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 8.193207e-05 | 4.087 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 8.281002e-05 | 4.082 |
| R-HSA-390522 | Striated Muscle Contraction | 9.315462e-05 | 4.031 |
| R-HSA-109582 | Hemostasis | 9.074596e-05 | 4.042 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.098198e-04 | 3.959 |
| R-HSA-190861 | Gap junction assembly | 1.044646e-04 | 3.981 |
| R-HSA-373760 | L1CAM interactions | 1.141484e-04 | 3.943 |
| R-HSA-5617833 | Cilium Assembly | 1.279360e-04 | 3.893 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.446913e-04 | 3.840 |
| R-HSA-9834899 | Specification of the neural plate border | 1.622520e-04 | 3.790 |
| R-HSA-9646399 | Aggrephagy | 1.960787e-04 | 3.708 |
| R-HSA-422475 | Axon guidance | 2.032532e-04 | 3.692 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.121104e-04 | 3.673 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.755714e-04 | 3.560 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.904589e-04 | 3.537 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.941042e-04 | 3.531 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.144317e-04 | 3.502 |
| R-HSA-380287 | Centrosome maturation | 3.574637e-04 | 3.447 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.998305e-04 | 3.398 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.998305e-04 | 3.398 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 4.008599e-04 | 3.397 |
| R-HSA-9675108 | Nervous system development | 4.190504e-04 | 3.378 |
| R-HSA-1632852 | Macroautophagy | 4.191252e-04 | 3.378 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 5.349475e-04 | 3.272 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.610516e-04 | 3.119 |
| R-HSA-9612973 | Autophagy | 7.818873e-04 | 3.107 |
| R-HSA-9663891 | Selective autophagy | 8.026028e-04 | 3.095 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 9.472410e-04 | 3.024 |
| R-HSA-391251 | Protein folding | 1.037289e-03 | 2.984 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.037289e-03 | 2.984 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.247734e-03 | 2.904 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.247734e-03 | 2.904 |
| R-HSA-373755 | Semaphorin interactions | 1.247734e-03 | 2.904 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 1.464542e-03 | 2.834 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.494557e-03 | 2.825 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.677937e-03 | 2.775 |
| R-HSA-1280218 | Adaptive Immune System | 1.699050e-03 | 2.770 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.728814e-03 | 2.762 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.093518e-03 | 2.679 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 2.093702e-03 | 2.679 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.234977e-03 | 2.651 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.587064e-03 | 2.587 |
| R-HSA-2262752 | Cellular responses to stress | 2.668146e-03 | 2.574 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.824335e-03 | 2.549 |
| R-HSA-373753 | Nephrin family interactions | 2.824335e-03 | 2.549 |
| R-HSA-9833482 | PKR-mediated signaling | 3.142857e-03 | 2.503 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.501075e-03 | 2.456 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.789799e-03 | 2.421 |
| R-HSA-5357801 | Programmed Cell Death | 3.818404e-03 | 2.418 |
| R-HSA-109581 | Apoptosis | 4.149881e-03 | 2.382 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.268994e-03 | 2.370 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.864660e-03 | 2.313 |
| R-HSA-397014 | Muscle contraction | 4.574832e-03 | 2.340 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.076563e-03 | 2.294 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 5.131513e-03 | 2.290 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.143174e-03 | 2.289 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 6.091700e-03 | 2.215 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.156240e-03 | 2.211 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.981156e-03 | 2.156 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 8.019310e-03 | 2.096 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 8.019310e-03 | 2.096 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.226241e-02 | 1.911 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.226241e-02 | 1.911 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.244757e-02 | 1.905 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.120458e-02 | 1.951 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.203718e-02 | 1.919 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.274766e-02 | 1.895 |
| R-HSA-162582 | Signal Transduction | 1.432782e-02 | 1.844 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.531418e-02 | 1.815 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.663162e-02 | 1.779 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.772595e-02 | 1.751 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.103168e-02 | 1.677 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.109816e-02 | 1.676 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.109816e-02 | 1.676 |
| R-HSA-114608 | Platelet degranulation | 2.148211e-02 | 1.668 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.182711e-02 | 1.661 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.508692e-02 | 1.601 |
| R-HSA-9827857 | Specification of primordial germ cells | 2.508692e-02 | 1.601 |
| R-HSA-5620924 | Intraflagellar transport | 2.478716e-02 | 1.606 |
| R-HSA-1474165 | Reproduction | 2.384472e-02 | 1.623 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.478716e-02 | 1.606 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.572264e-02 | 1.590 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.652335e-02 | 1.576 |
| R-HSA-1221632 | Meiotic synapsis | 3.079630e-02 | 1.512 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.079630e-02 | 1.512 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 3.170921e-02 | 1.499 |
| R-HSA-9609690 | HCMV Early Events | 3.324934e-02 | 1.478 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 3.405327e-02 | 1.468 |
| R-HSA-1500931 | Cell-Cell communication | 3.427820e-02 | 1.465 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.560309e-02 | 1.449 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.560309e-02 | 1.449 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 3.893592e-02 | 1.410 |
| R-HSA-9758941 | Gastrulation | 3.896910e-02 | 1.409 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.065584e-02 | 1.391 |
| R-HSA-198765 | Signalling to ERK5 | 4.325737e-02 | 1.364 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.803000e-02 | 1.318 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.962979e-02 | 1.304 |
| R-HSA-3295583 | TRP channels | 4.943257e-02 | 1.306 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4.943257e-02 | 1.306 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.611126e-02 | 1.336 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 4.147112e-02 | 1.382 |
| R-HSA-162587 | HIV Life Cycle | 4.597931e-02 | 1.337 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.406670e-02 | 1.356 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.406670e-02 | 1.356 |
| R-HSA-9824446 | Viral Infection Pathways | 5.148275e-02 | 1.288 |
| R-HSA-264876 | Insulin processing | 5.219970e-02 | 1.282 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 5.219970e-02 | 1.282 |
| R-HSA-77387 | Insulin receptor recycling | 5.502091e-02 | 1.259 |
| R-HSA-162906 | HIV Infection | 5.775230e-02 | 1.238 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 5.789469e-02 | 1.237 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.853807e-02 | 1.233 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 6.081956e-02 | 1.216 |
| R-HSA-68875 | Mitotic Prophase | 6.252435e-02 | 1.204 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.433808e-02 | 1.192 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 7.447461e-02 | 1.128 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 9.472126e-02 | 1.024 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.046788e-01 | 0.980 |
| R-HSA-196025 | Formation of annular gap junctions | 1.145274e-01 | 0.941 |
| R-HSA-190873 | Gap junction degradation | 1.242683e-01 | 0.906 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.242683e-01 | 0.906 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.339027e-01 | 0.873 |
| R-HSA-164843 | 2-LTR circle formation | 1.339027e-01 | 0.873 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.528563e-01 | 0.816 |
| R-HSA-202670 | ERKs are inactivated | 1.528563e-01 | 0.816 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.805160e-01 | 0.743 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 1.984550e-01 | 0.702 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.072776e-01 | 0.683 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.072776e-01 | 0.683 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.416125e-01 | 0.617 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.499625e-01 | 0.602 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.170422e-01 | 0.932 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.582212e-01 | 0.588 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.582212e-01 | 0.588 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.429141e-01 | 0.845 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.467039e-01 | 0.834 |
| R-HSA-72649 | Translation initiation complex formation | 1.505143e-01 | 0.822 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.581933e-01 | 0.801 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 1.895612e-01 | 0.722 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.257232e-01 | 0.646 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.891038e-02 | 1.051 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.623387e-01 | 0.581 |
| R-HSA-72172 | mRNA Splicing | 1.042364e-01 | 0.982 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.026708e-01 | 0.693 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.026708e-01 | 0.693 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.895349e-01 | 0.722 |
| R-HSA-354192 | Integrin signaling | 6.988624e-02 | 1.156 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.026708e-01 | 0.693 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.663894e-01 | 0.574 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.391458e-01 | 0.857 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 1.170422e-01 | 0.932 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 8.921023e-02 | 1.050 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.704945e-01 | 0.568 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 7.447461e-02 | 1.128 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.072776e-01 | 0.683 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 8.588812e-02 | 1.066 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.028629e-01 | 0.988 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 1.467039e-01 | 0.834 |
| R-HSA-3928664 | Ephrin signaling | 2.246340e-01 | 0.649 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.543444e-01 | 0.812 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.044891e-01 | 0.981 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.028629e-01 | 0.988 |
| R-HSA-198753 | ERK/MAPK targets | 2.499625e-01 | 0.602 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.206609e-01 | 0.918 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.206609e-01 | 0.918 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.206609e-01 | 0.918 |
| R-HSA-8951664 | Neddylation | 1.302984e-01 | 0.885 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 9.596611e-02 | 1.018 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.242683e-01 | 0.906 |
| R-HSA-9907900 | Proteasome assembly | 1.134519e-01 | 0.945 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 8.499109e-02 | 1.071 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 1.068912e-01 | 0.971 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.581933e-01 | 0.801 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.244999e-01 | 0.905 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.339027e-01 | 0.873 |
| R-HSA-192814 | vRNA Synthesis | 1.434316e-01 | 0.843 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.528563e-01 | 0.816 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.621778e-01 | 0.790 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.713974e-01 | 0.766 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.713974e-01 | 0.766 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 8.260489e-02 | 1.083 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.246340e-01 | 0.649 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.582212e-01 | 0.588 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 9.760976e-02 | 1.011 |
| R-HSA-9664407 | Parasite infection | 9.760976e-02 | 1.011 |
| R-HSA-9664417 | Leishmania phagocytosis | 9.760976e-02 | 1.011 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.895349e-01 | 0.722 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.935423e-01 | 0.713 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.621778e-01 | 0.790 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.206609e-01 | 0.918 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.787847e-02 | 1.056 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.321536e-01 | 0.879 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.984550e-01 | 0.702 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.206609e-01 | 0.918 |
| R-HSA-1500620 | Meiosis | 8.499109e-02 | 1.071 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.176321e-01 | 0.662 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.176321e-01 | 0.662 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.242683e-01 | 0.906 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.434316e-01 | 0.843 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.805160e-01 | 0.743 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.206609e-01 | 0.918 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.659442e-01 | 0.780 |
| R-HSA-9664873 | Pexophagy | 1.339027e-01 | 0.873 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 1.816345e-01 | 0.741 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 9.930902e-02 | 1.003 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.242683e-01 | 0.906 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.805160e-01 | 0.743 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 1.170422e-01 | 0.932 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.170422e-01 | 0.932 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.722398e-01 | 0.764 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 1.528563e-01 | 0.816 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.805160e-01 | 0.743 |
| R-HSA-418457 | cGMP effects | 1.805160e-01 | 0.743 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.160035e-01 | 0.666 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.582212e-01 | 0.588 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.467039e-01 | 0.834 |
| R-HSA-194138 | Signaling by VEGF | 2.026708e-01 | 0.693 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.134519e-01 | 0.945 |
| R-HSA-416700 | Other semaphorin interactions | 1.895349e-01 | 0.722 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 9.939747e-02 | 1.003 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.170422e-01 | 0.932 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.970432e-01 | 0.705 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.412071e-01 | 0.618 |
| R-HSA-9658195 | Leishmania infection | 2.412071e-01 | 0.618 |
| R-HSA-162592 | Integration of provirus | 1.528563e-01 | 0.816 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.816345e-01 | 0.741 |
| R-HSA-4086400 | PCP/CE pathway | 7.095647e-02 | 1.149 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.805160e-01 | 0.743 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.895349e-01 | 0.722 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.160035e-01 | 0.666 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.243071e-01 | 0.906 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.460370e-01 | 0.609 |
| R-HSA-913531 | Interferon Signaling | 1.620999e-01 | 0.790 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.895349e-01 | 0.722 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 7.936179e-02 | 1.100 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 1.206609e-01 | 0.918 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.257232e-01 | 0.646 |
| R-HSA-73884 | Base Excision Repair | 9.788317e-02 | 1.009 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.805160e-01 | 0.743 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 1.063612e-01 | 0.973 |
| R-HSA-69242 | S Phase | 2.785186e-01 | 0.555 |
| R-HSA-9609646 | HCMV Infection | 8.066388e-02 | 1.093 |
| R-HSA-9659379 | Sensory processing of sound | 2.501099e-01 | 0.602 |
| R-HSA-8964038 | LDL clearance | 2.663894e-01 | 0.574 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.339027e-01 | 0.873 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.895349e-01 | 0.722 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.160035e-01 | 0.666 |
| R-HSA-8854214 | TBC/RABGAPs | 1.098912e-01 | 0.959 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.055478e-01 | 0.687 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.957443e-01 | 0.708 |
| R-HSA-597592 | Post-translational protein modification | 2.314192e-01 | 0.636 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.226169e-01 | 0.911 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 9.095233e-02 | 1.041 |
| R-HSA-168255 | Influenza Infection | 1.774337e-01 | 0.751 |
| R-HSA-2028269 | Signaling by Hippo | 2.160035e-01 | 0.666 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.357113e-01 | 0.867 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.294773e-01 | 0.888 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.606784e-01 | 0.584 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.984550e-01 | 0.702 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.581933e-01 | 0.801 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.394857e-01 | 0.855 |
| R-HSA-983712 | Ion channel transport | 1.995577e-01 | 0.700 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.216746e-01 | 0.654 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.606784e-01 | 0.584 |
| R-HSA-9758890 | Transport of RCbl within the body | 1.434316e-01 | 0.843 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.434316e-01 | 0.843 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.713974e-01 | 0.766 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.331699e-01 | 0.632 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.162102e-01 | 0.935 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.151383e-01 | 0.667 |
| R-HSA-5358351 | Signaling by Hedgehog | 9.425294e-02 | 1.026 |
| R-HSA-5693538 | Homology Directed Repair | 1.804066e-01 | 0.744 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.787847e-02 | 1.056 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.242683e-01 | 0.906 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.339027e-01 | 0.873 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.805160e-01 | 0.743 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.895349e-01 | 0.722 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.160035e-01 | 0.666 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.142618e-01 | 0.942 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.499625e-01 | 0.602 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.664166e-01 | 0.574 |
| R-HSA-9734767 | Developmental Cell Lineages | 2.053638e-01 | 0.687 |
| R-HSA-195721 | Signaling by WNT | 2.764866e-01 | 0.558 |
| R-HSA-74752 | Signaling by Insulin receptor | 1.046094e-01 | 0.980 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.582212e-01 | 0.588 |
| R-HSA-9645723 | Diseases of programmed cell death | 9.350105e-02 | 1.029 |
| R-HSA-1266738 | Developmental Biology | 1.394781e-01 | 0.855 |
| R-HSA-168256 | Immune System | 9.705855e-02 | 1.013 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.331699e-01 | 0.632 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.663894e-01 | 0.574 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.170431e-01 | 0.932 |
| R-HSA-5663205 | Infectious disease | 1.899547e-01 | 0.721 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.176864e-01 | 0.929 |
| R-HSA-1643685 | Disease | 2.764644e-01 | 0.558 |
| R-HSA-917937 | Iron uptake and transport | 2.338364e-01 | 0.631 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.543444e-01 | 0.812 |
| R-HSA-8854691 | Interleukin-20 family signaling | 2.744682e-01 | 0.562 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.331699e-01 | 0.632 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.693260e-01 | 0.570 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.745719e-01 | 0.561 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.713974e-01 | 0.766 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 1.737600e-01 | 0.760 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.160035e-01 | 0.666 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.206696e-01 | 0.656 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.805160e-01 | 0.743 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.331699e-01 | 0.632 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.246340e-01 | 0.649 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.663894e-01 | 0.574 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.935423e-01 | 0.713 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 1.659442e-01 | 0.780 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 2.297773e-01 | 0.639 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 9.592437e-02 | 1.018 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.378997e-01 | 0.624 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.786484e-01 | 0.555 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.844932e-01 | 0.546 |
| R-HSA-70268 | Pyruvate metabolism | 2.867964e-01 | 0.542 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.867964e-01 | 0.542 |
| R-HSA-9620244 | Long-term potentiation | 2.903613e-01 | 0.537 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.903613e-01 | 0.537 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.903613e-01 | 0.537 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.903613e-01 | 0.537 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.903613e-01 | 0.537 |
| R-HSA-112316 | Neuronal System | 2.977062e-01 | 0.526 |
| R-HSA-8874081 | MET activates PTK2 signaling | 2.981776e-01 | 0.526 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.981776e-01 | 0.526 |
| R-HSA-70635 | Urea cycle | 2.981776e-01 | 0.526 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.981776e-01 | 0.526 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.059082e-01 | 0.514 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.059082e-01 | 0.514 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 3.059082e-01 | 0.514 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.135541e-01 | 0.504 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.211163e-01 | 0.493 |
| R-HSA-5334118 | DNA methylation | 3.211163e-01 | 0.493 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.211163e-01 | 0.493 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 3.211163e-01 | 0.493 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.211163e-01 | 0.493 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.211163e-01 | 0.493 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.273286e-01 | 0.485 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.285957e-01 | 0.483 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.353712e-01 | 0.474 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.359931e-01 | 0.474 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.359931e-01 | 0.474 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.359931e-01 | 0.474 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.359931e-01 | 0.474 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.359931e-01 | 0.474 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.359931e-01 | 0.474 |
| R-HSA-422356 | Regulation of insulin secretion | 3.393822e-01 | 0.469 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.433094e-01 | 0.464 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.433094e-01 | 0.464 |
| R-HSA-69190 | DNA strand elongation | 3.433094e-01 | 0.464 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.433858e-01 | 0.464 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.473818e-01 | 0.459 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.505456e-01 | 0.455 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.505456e-01 | 0.455 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.505456e-01 | 0.455 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.505456e-01 | 0.455 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.505456e-01 | 0.455 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.505456e-01 | 0.455 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.505456e-01 | 0.455 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 3.505887e-01 | 0.455 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.513698e-01 | 0.454 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.513698e-01 | 0.454 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.553496e-01 | 0.449 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.553496e-01 | 0.449 |
| R-HSA-1483255 | PI Metabolism | 3.553496e-01 | 0.449 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 3.565921e-01 | 0.448 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 3.565921e-01 | 0.448 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.577025e-01 | 0.446 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.577025e-01 | 0.446 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.577025e-01 | 0.446 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.577025e-01 | 0.446 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.577025e-01 | 0.446 |
| R-HSA-189483 | Heme degradation | 3.577025e-01 | 0.446 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.625885e-01 | 0.441 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.632831e-01 | 0.440 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.647810e-01 | 0.438 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.647810e-01 | 0.438 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.647810e-01 | 0.438 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.647810e-01 | 0.438 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.647810e-01 | 0.438 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 3.647810e-01 | 0.438 |
| R-HSA-5205647 | Mitophagy | 3.647810e-01 | 0.438 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.647810e-01 | 0.438 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.647810e-01 | 0.438 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.711799e-01 | 0.430 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.717819e-01 | 0.430 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.717819e-01 | 0.430 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.717819e-01 | 0.430 |
| R-HSA-169911 | Regulation of Apoptosis | 3.717819e-01 | 0.430 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.717819e-01 | 0.430 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.717819e-01 | 0.430 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.787060e-01 | 0.422 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.787060e-01 | 0.422 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.787060e-01 | 0.422 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.787060e-01 | 0.422 |
| R-HSA-3371511 | HSF1 activation | 3.787060e-01 | 0.422 |
| R-HSA-8853659 | RET signaling | 3.787060e-01 | 0.422 |
| R-HSA-69239 | Synthesis of DNA | 3.790380e-01 | 0.421 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.829518e-01 | 0.417 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.829518e-01 | 0.417 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.829518e-01 | 0.417 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.855543e-01 | 0.414 |
| R-HSA-4641258 | Degradation of DVL | 3.855543e-01 | 0.414 |
| R-HSA-4641257 | Degradation of AXIN | 3.855543e-01 | 0.414 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.855543e-01 | 0.414 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.855543e-01 | 0.414 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.855543e-01 | 0.414 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.867381e-01 | 0.413 |
| R-HSA-8875878 | MET promotes cell motility | 3.923275e-01 | 0.406 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.923275e-01 | 0.406 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.990264e-01 | 0.399 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.990264e-01 | 0.399 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.990264e-01 | 0.399 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.990264e-01 | 0.399 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.990264e-01 | 0.399 |
| R-HSA-69541 | Stabilization of p53 | 3.990264e-01 | 0.399 |
| R-HSA-201556 | Signaling by ALK | 3.990264e-01 | 0.399 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.990264e-01 | 0.399 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.056519e-01 | 0.392 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.056519e-01 | 0.392 |
| R-HSA-3371568 | Attenuation phase | 4.056519e-01 | 0.392 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.056519e-01 | 0.392 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.056519e-01 | 0.392 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.056519e-01 | 0.392 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.062067e-01 | 0.391 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.122048e-01 | 0.385 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.122048e-01 | 0.385 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.122048e-01 | 0.385 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.122048e-01 | 0.385 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.138661e-01 | 0.383 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.172443e-01 | 0.380 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 4.176775e-01 | 0.379 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 4.176775e-01 | 0.379 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.186858e-01 | 0.378 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.186858e-01 | 0.378 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.186858e-01 | 0.378 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.186858e-01 | 0.378 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.186858e-01 | 0.378 |
| R-HSA-9683701 | Translation of Structural Proteins | 4.186858e-01 | 0.378 |
| R-HSA-446728 | Cell junction organization | 4.189497e-01 | 0.378 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.214765e-01 | 0.375 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.214765e-01 | 0.375 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.248219e-01 | 0.372 |
| R-HSA-2980736 | Peptide hormone metabolism | 4.252629e-01 | 0.371 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.288006e-01 | 0.368 |
| R-HSA-9710421 | Defective pyroptosis | 4.314355e-01 | 0.365 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.314355e-01 | 0.365 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.314355e-01 | 0.365 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.363012e-01 | 0.360 |
| R-HSA-373752 | Netrin-1 signaling | 4.377056e-01 | 0.359 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.377056e-01 | 0.359 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.377056e-01 | 0.359 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 4.377056e-01 | 0.359 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 4.377056e-01 | 0.359 |
| R-HSA-3371556 | Cellular response to heat stress | 4.402787e-01 | 0.356 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.439070e-01 | 0.353 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.439070e-01 | 0.353 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.439070e-01 | 0.353 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.439070e-01 | 0.353 |
| R-HSA-9824272 | Somitogenesis | 4.439070e-01 | 0.353 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.451363e-01 | 0.352 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.500404e-01 | 0.347 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.500404e-01 | 0.347 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 4.500404e-01 | 0.347 |
| R-HSA-9679506 | SARS-CoV Infections | 4.534894e-01 | 0.343 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.561065e-01 | 0.341 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.561065e-01 | 0.341 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.621061e-01 | 0.335 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 4.623953e-01 | 0.335 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.625084e-01 | 0.335 |
| R-HSA-9766229 | Degradation of CDH1 | 4.680399e-01 | 0.330 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.680399e-01 | 0.330 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.680399e-01 | 0.330 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.696543e-01 | 0.328 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.739085e-01 | 0.324 |
| R-HSA-109704 | PI3K Cascade | 4.739085e-01 | 0.324 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.797128e-01 | 0.319 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.797128e-01 | 0.319 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.797128e-01 | 0.319 |
| R-HSA-2514856 | The phototransduction cascade | 4.797128e-01 | 0.319 |
| R-HSA-72187 | mRNA 3'-end processing | 4.854534e-01 | 0.314 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.854534e-01 | 0.314 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.854534e-01 | 0.314 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.854534e-01 | 0.314 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.854534e-01 | 0.314 |
| R-HSA-418990 | Adherens junctions interactions | 4.904487e-01 | 0.309 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.911310e-01 | 0.309 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.911310e-01 | 0.309 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.967463e-01 | 0.304 |
| R-HSA-9753281 | Paracetamol ADME | 5.023000e-01 | 0.299 |
| R-HSA-163685 | Integration of energy metabolism | 5.050568e-01 | 0.297 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.077927e-01 | 0.294 |
| R-HSA-5578775 | Ion homeostasis | 5.077927e-01 | 0.294 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.077927e-01 | 0.294 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.077927e-01 | 0.294 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.085128e-01 | 0.294 |
| R-HSA-112399 | IRS-mediated signalling | 5.132252e-01 | 0.290 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.132252e-01 | 0.290 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.178448e-01 | 0.286 |
| R-HSA-392499 | Metabolism of proteins | 5.203868e-01 | 0.284 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.239119e-01 | 0.281 |
| R-HSA-191859 | snRNP Assembly | 5.239119e-01 | 0.281 |
| R-HSA-180786 | Extension of Telomeres | 5.239119e-01 | 0.281 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.291674e-01 | 0.276 |
| R-HSA-351202 | Metabolism of polyamines | 5.291674e-01 | 0.276 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.291674e-01 | 0.276 |
| R-HSA-168249 | Innate Immune System | 5.305885e-01 | 0.275 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.339017e-01 | 0.273 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.343653e-01 | 0.272 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.343653e-01 | 0.272 |
| R-HSA-450294 | MAP kinase activation | 5.343653e-01 | 0.272 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.343653e-01 | 0.272 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.343653e-01 | 0.272 |
| R-HSA-112043 | PLC beta mediated events | 5.343653e-01 | 0.272 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.343653e-01 | 0.272 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.355914e-01 | 0.271 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.395060e-01 | 0.268 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.395060e-01 | 0.268 |
| R-HSA-9707616 | Heme signaling | 5.395060e-01 | 0.268 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.395060e-01 | 0.268 |
| R-HSA-8939211 | ESR-mediated signaling | 5.418176e-01 | 0.266 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.445904e-01 | 0.264 |
| R-HSA-166520 | Signaling by NTRKs | 5.487446e-01 | 0.261 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.496189e-01 | 0.260 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.496189e-01 | 0.260 |
| R-HSA-157118 | Signaling by NOTCH | 5.496564e-01 | 0.260 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.545922e-01 | 0.256 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.616364e-01 | 0.251 |
| R-HSA-112040 | G-protein mediated events | 5.643755e-01 | 0.248 |
| R-HSA-196807 | Nicotinate metabolism | 5.643755e-01 | 0.248 |
| R-HSA-69306 | DNA Replication | 5.648183e-01 | 0.248 |
| R-HSA-73887 | Death Receptor Signaling | 5.679836e-01 | 0.246 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 5.691868e-01 | 0.245 |
| R-HSA-5218859 | Regulated Necrosis | 5.691868e-01 | 0.245 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.711324e-01 | 0.243 |
| R-HSA-4839726 | Chromatin organization | 5.726970e-01 | 0.242 |
| R-HSA-421270 | Cell-cell junction organization | 5.777179e-01 | 0.238 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.786513e-01 | 0.238 |
| R-HSA-448424 | Interleukin-17 signaling | 5.786513e-01 | 0.238 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.786513e-01 | 0.238 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.786513e-01 | 0.238 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.786513e-01 | 0.238 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.786513e-01 | 0.238 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.786513e-01 | 0.238 |
| R-HSA-9711097 | Cellular response to starvation | 5.804796e-01 | 0.236 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.833057e-01 | 0.234 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.833057e-01 | 0.234 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.833057e-01 | 0.234 |
| R-HSA-189445 | Metabolism of porphyrins | 5.833057e-01 | 0.234 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.866281e-01 | 0.232 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.879091e-01 | 0.231 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.879091e-01 | 0.231 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.879091e-01 | 0.231 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.924618e-01 | 0.227 |
| R-HSA-4086398 | Ca2+ pathway | 5.924618e-01 | 0.227 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.969645e-01 | 0.224 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.014178e-01 | 0.221 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.014178e-01 | 0.221 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.014178e-01 | 0.221 |
| R-HSA-5689603 | UCH proteinases | 6.058221e-01 | 0.218 |
| R-HSA-73894 | DNA Repair | 6.073382e-01 | 0.217 |
| R-HSA-8953854 | Metabolism of RNA | 6.084635e-01 | 0.216 |
| R-HSA-416476 | G alpha (q) signalling events | 6.094466e-01 | 0.215 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.101780e-01 | 0.215 |
| R-HSA-5619084 | ABC transporter disorders | 6.144860e-01 | 0.211 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 6.144860e-01 | 0.211 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.229606e-01 | 0.206 |
| R-HSA-6806834 | Signaling by MET | 6.229606e-01 | 0.206 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.229606e-01 | 0.206 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.278062e-01 | 0.202 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.278062e-01 | 0.202 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.312499e-01 | 0.200 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.353264e-01 | 0.197 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.393580e-01 | 0.194 |
| R-HSA-2559583 | Cellular Senescence | 6.471783e-01 | 0.189 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.472888e-01 | 0.189 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.552346e-01 | 0.184 |
| R-HSA-173623 | Classical antibody-mediated complement activation | 6.588609e-01 | 0.181 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.626338e-01 | 0.179 |
| R-HSA-202424 | Downstream TCR signaling | 6.663651e-01 | 0.176 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.760042e-01 | 0.170 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.773147e-01 | 0.169 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.773147e-01 | 0.169 |
| R-HSA-2029481 | FCGR activation | 6.808846e-01 | 0.167 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.808846e-01 | 0.167 |
| R-HSA-1474290 | Collagen formation | 6.844152e-01 | 0.165 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.913603e-01 | 0.160 |
| R-HSA-2168880 | Scavenging of heme from plasma | 6.913603e-01 | 0.160 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.947756e-01 | 0.158 |
| R-HSA-157579 | Telomere Maintenance | 6.981533e-01 | 0.156 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.981533e-01 | 0.156 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.014939e-01 | 0.154 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.014939e-01 | 0.154 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.014939e-01 | 0.154 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.014939e-01 | 0.154 |
| R-HSA-3214847 | HATs acetylate histones | 7.047977e-01 | 0.152 |
| R-HSA-70171 | Glycolysis | 7.080652e-01 | 0.150 |
| R-HSA-111885 | Opioid Signalling | 7.207792e-01 | 0.142 |
| R-HSA-449147 | Signaling by Interleukins | 7.222824e-01 | 0.141 |
| R-HSA-9833110 | RSV-host interactions | 7.238708e-01 | 0.140 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.269282e-01 | 0.139 |
| R-HSA-166786 | Creation of C4 and C2 activators | 7.299520e-01 | 0.137 |
| R-HSA-418346 | Platelet homeostasis | 7.299520e-01 | 0.137 |
| R-HSA-211000 | Gene Silencing by RNA | 7.329426e-01 | 0.135 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.359001e-01 | 0.133 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.359001e-01 | 0.133 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.388252e-01 | 0.131 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.388252e-01 | 0.131 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.417179e-01 | 0.130 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.417179e-01 | 0.130 |
| R-HSA-202403 | TCR signaling | 7.417179e-01 | 0.130 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.474083e-01 | 0.126 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.474083e-01 | 0.126 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.502065e-01 | 0.125 |
| R-HSA-166663 | Initial triggering of complement | 7.557109e-01 | 0.122 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.557109e-01 | 0.122 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.571788e-01 | 0.121 |
| R-HSA-909733 | Interferon alpha/beta signaling | 7.610946e-01 | 0.119 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 7.630857e-01 | 0.117 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.650269e-01 | 0.116 |
| R-HSA-70326 | Glucose metabolism | 7.663604e-01 | 0.116 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.715107e-01 | 0.113 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.715107e-01 | 0.113 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.715107e-01 | 0.113 |
| R-HSA-73886 | Chromosome Maintenance | 7.765481e-01 | 0.110 |
| R-HSA-6798695 | Neutrophil degranulation | 7.768509e-01 | 0.110 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.790252e-01 | 0.108 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.790252e-01 | 0.108 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 7.814750e-01 | 0.107 |
| R-HSA-977606 | Regulation of Complement cascade | 7.862939e-01 | 0.104 |
| R-HSA-69206 | G1/S Transition | 7.886636e-01 | 0.103 |
| R-HSA-69481 | G2/M Checkpoints | 7.933249e-01 | 0.101 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.959803e-01 | 0.099 |
| R-HSA-5576891 | Cardiac conduction | 8.045356e-01 | 0.094 |
| R-HSA-9717189 | Sensory perception of taste | 8.045356e-01 | 0.094 |
| R-HSA-9909396 | Circadian clock | 8.067040e-01 | 0.093 |
| R-HSA-5688426 | Deubiquitination | 8.092662e-01 | 0.092 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.171928e-01 | 0.088 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.212281e-01 | 0.086 |
| R-HSA-6807070 | PTEN Regulation | 8.232124e-01 | 0.084 |
| R-HSA-166658 | Complement cascade | 8.365024e-01 | 0.078 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.383181e-01 | 0.077 |
| R-HSA-2187338 | Visual phototransduction | 8.401137e-01 | 0.076 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.418895e-01 | 0.075 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.453824e-01 | 0.073 |
| R-HSA-74160 | Gene expression (Transcription) | 8.477916e-01 | 0.072 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.487986e-01 | 0.071 |
| R-HSA-2142753 | Arachidonate metabolism | 8.487986e-01 | 0.071 |
| R-HSA-9610379 | HCMV Late Events | 8.570142e-01 | 0.067 |
| R-HSA-1483257 | Phospholipid metabolism | 8.648034e-01 | 0.063 |
| R-HSA-382551 | Transport of small molecules | 8.697707e-01 | 0.061 |
| R-HSA-5619102 | SLC transporter disorders | 8.721373e-01 | 0.059 |
| R-HSA-72766 | Translation | 8.767384e-01 | 0.057 |
| R-HSA-72306 | tRNA processing | 8.777312e-01 | 0.057 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.804361e-01 | 0.055 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.817662e-01 | 0.055 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.977756e-01 | 0.047 |
| R-HSA-1474244 | Extracellular matrix organization | 9.017384e-01 | 0.045 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.054831e-01 | 0.043 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.101983e-01 | 0.041 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.110059e-01 | 0.040 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.126125e-01 | 0.040 |
| R-HSA-428157 | Sphingolipid metabolism | 9.135864e-01 | 0.039 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.155018e-01 | 0.038 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.271471e-01 | 0.033 |
| R-HSA-9748784 | Drug ADME | 9.293805e-01 | 0.032 |
| R-HSA-388396 | GPCR downstream signalling | 9.419290e-01 | 0.026 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.429456e-01 | 0.026 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.539169e-01 | 0.020 |
| R-HSA-372790 | Signaling by GPCR | 9.681268e-01 | 0.014 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.692310e-01 | 0.014 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.702958e-01 | 0.013 |
| R-HSA-212436 | Generic Transcription Pathway | 9.831209e-01 | 0.007 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.856870e-01 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.899694e-01 | 0.004 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.904144e-01 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.907352e-01 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 9.917294e-01 | 0.004 |
| R-HSA-8978868 | Fatty acid metabolism | 9.917294e-01 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.938079e-01 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 9.989655e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.996438e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999954e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.822 | 0.018 | 2 | 0.758 |
PRKD1 |
0.819 | 0.277 | -3 | 0.839 |
PRKD2 |
0.817 | 0.210 | -3 | 0.820 |
TSSK2 |
0.815 | 0.285 | -5 | 0.656 |
CAMK1B |
0.815 | 0.115 | -3 | 0.892 |
ATR |
0.814 | 0.187 | 1 | 0.929 |
CDC7 |
0.813 | 0.023 | 1 | 0.826 |
TSSK1 |
0.813 | 0.244 | -3 | 0.901 |
NLK |
0.812 | 0.059 | 1 | 0.775 |
MAPKAPK3 |
0.812 | 0.138 | -3 | 0.818 |
MAPKAPK2 |
0.812 | 0.138 | -3 | 0.786 |
MOS |
0.810 | 0.007 | 1 | 0.853 |
PRKD3 |
0.810 | 0.223 | -3 | 0.795 |
PRPK |
0.809 | -0.108 | -1 | 0.804 |
PIM3 |
0.809 | 0.009 | -3 | 0.869 |
ATM |
0.808 | 0.211 | 1 | 0.919 |
CDKL1 |
0.808 | 0.046 | -3 | 0.827 |
GCN2 |
0.807 | -0.075 | 2 | 0.723 |
AMPKA1 |
0.807 | 0.112 | -3 | 0.889 |
BMPR2 |
0.807 | -0.032 | -2 | 0.880 |
MELK |
0.807 | 0.169 | -3 | 0.846 |
PIM1 |
0.807 | 0.084 | -3 | 0.840 |
NUAK2 |
0.806 | 0.093 | -3 | 0.885 |
CLK3 |
0.806 | 0.039 | 1 | 0.836 |
PKN3 |
0.805 | 0.046 | -3 | 0.856 |
NIK |
0.805 | 0.067 | -3 | 0.902 |
ERK5 |
0.805 | 0.032 | 1 | 0.739 |
TGFBR2 |
0.805 | 0.028 | -2 | 0.814 |
RAF1 |
0.805 | -0.089 | 1 | 0.784 |
CAMK4 |
0.804 | 0.112 | -3 | 0.870 |
RSK2 |
0.804 | 0.046 | -3 | 0.813 |
ULK2 |
0.804 | -0.082 | 2 | 0.735 |
NUAK1 |
0.804 | 0.139 | -3 | 0.845 |
CHK1 |
0.803 | 0.252 | -3 | 0.863 |
DSTYK |
0.803 | -0.061 | 2 | 0.730 |
RIPK3 |
0.802 | 0.007 | 3 | 0.727 |
LATS2 |
0.802 | -0.005 | -5 | 0.462 |
WNK1 |
0.802 | 0.030 | -2 | 0.802 |
DAPK2 |
0.802 | 0.069 | -3 | 0.884 |
WNK3 |
0.801 | -0.034 | 1 | 0.791 |
NDR2 |
0.801 | -0.049 | -3 | 0.870 |
CAMLCK |
0.801 | 0.023 | -2 | 0.813 |
AMPKA2 |
0.801 | 0.104 | -3 | 0.865 |
TBK1 |
0.801 | -0.087 | 1 | 0.659 |
SMG1 |
0.801 | 0.226 | 1 | 0.920 |
P90RSK |
0.800 | 0.047 | -3 | 0.805 |
IKKB |
0.800 | -0.112 | -2 | 0.759 |
IRE2 |
0.800 | 0.042 | 2 | 0.747 |
CDKL5 |
0.800 | 0.029 | -3 | 0.815 |
PKN2 |
0.800 | 0.042 | -3 | 0.877 |
GRK6 |
0.799 | 0.001 | 1 | 0.795 |
MLK1 |
0.799 | -0.069 | 2 | 0.711 |
CAMK2G |
0.799 | -0.081 | 2 | 0.680 |
PDHK4 |
0.798 | -0.200 | 1 | 0.802 |
SKMLCK |
0.798 | 0.010 | -2 | 0.791 |
NDR1 |
0.797 | -0.043 | -3 | 0.872 |
GRK5 |
0.796 | -0.097 | -3 | 0.862 |
PKCD |
0.796 | 0.009 | 2 | 0.686 |
ULK1 |
0.796 | -0.089 | -3 | 0.794 |
P70S6KB |
0.796 | -0.002 | -3 | 0.840 |
HUNK |
0.796 | -0.057 | 2 | 0.734 |
KIS |
0.796 | 0.017 | 1 | 0.650 |
NIM1 |
0.796 | 0.017 | 3 | 0.761 |
ALK4 |
0.796 | 0.057 | -2 | 0.850 |
CAMK2B |
0.795 | 0.087 | 2 | 0.643 |
CHAK2 |
0.795 | -0.044 | -1 | 0.792 |
IRE1 |
0.795 | 0.002 | 1 | 0.795 |
CAMK2D |
0.795 | 0.043 | -3 | 0.859 |
PDHK1 |
0.794 | -0.160 | 1 | 0.785 |
RSK3 |
0.794 | 0.006 | -3 | 0.807 |
NEK7 |
0.794 | -0.118 | -3 | 0.808 |
MTOR |
0.793 | -0.175 | 1 | 0.732 |
MARK4 |
0.793 | -0.002 | 4 | 0.792 |
MNK2 |
0.793 | 0.065 | -2 | 0.737 |
NEK6 |
0.793 | -0.076 | -2 | 0.829 |
ICK |
0.793 | 0.007 | -3 | 0.856 |
IKKE |
0.793 | -0.126 | 1 | 0.650 |
FAM20C |
0.793 | 0.029 | 2 | 0.527 |
GRK1 |
0.792 | -0.027 | -2 | 0.791 |
PKR |
0.792 | 0.006 | 1 | 0.833 |
BMPR1B |
0.792 | 0.048 | 1 | 0.726 |
RIPK1 |
0.791 | -0.041 | 1 | 0.780 |
IKKA |
0.791 | -0.074 | -2 | 0.751 |
MST4 |
0.791 | -0.050 | 2 | 0.700 |
TGFBR1 |
0.790 | 0.036 | -2 | 0.834 |
CAMK1G |
0.790 | 0.093 | -3 | 0.812 |
MLK3 |
0.790 | -0.026 | 2 | 0.637 |
PAK1 |
0.790 | -0.011 | -2 | 0.733 |
LATS1 |
0.790 | 0.000 | -3 | 0.871 |
ANKRD3 |
0.790 | -0.073 | 1 | 0.805 |
NEK9 |
0.789 | -0.099 | 2 | 0.737 |
DLK |
0.789 | -0.112 | 1 | 0.764 |
QIK |
0.789 | 0.046 | -3 | 0.856 |
PAK3 |
0.789 | -0.019 | -2 | 0.737 |
CAMK1D |
0.789 | 0.148 | -3 | 0.754 |
PKACG |
0.789 | -0.021 | -2 | 0.692 |
MLK2 |
0.789 | -0.088 | 2 | 0.719 |
SRPK1 |
0.789 | 0.009 | -3 | 0.788 |
HIPK4 |
0.788 | -0.017 | 1 | 0.769 |
MASTL |
0.788 | -0.157 | -2 | 0.787 |
PLK1 |
0.788 | -0.022 | -2 | 0.814 |
SIK |
0.788 | 0.064 | -3 | 0.814 |
TTBK2 |
0.788 | -0.111 | 2 | 0.631 |
GRK4 |
0.788 | -0.088 | -2 | 0.816 |
PHKG1 |
0.787 | 0.016 | -3 | 0.868 |
CAMK2A |
0.787 | 0.058 | 2 | 0.625 |
MNK1 |
0.787 | 0.052 | -2 | 0.753 |
ALK2 |
0.787 | 0.047 | -2 | 0.845 |
PIM2 |
0.787 | 0.033 | -3 | 0.795 |
BUB1 |
0.787 | 0.340 | -5 | 0.747 |
ACVR2A |
0.786 | 0.028 | -2 | 0.816 |
MYLK4 |
0.786 | 0.037 | -2 | 0.725 |
DCAMKL1 |
0.786 | 0.060 | -3 | 0.846 |
SSTK |
0.786 | 0.091 | 4 | 0.780 |
AURB |
0.786 | 0.017 | -2 | 0.618 |
SRPK2 |
0.786 | 0.018 | -3 | 0.722 |
AURC |
0.786 | 0.005 | -2 | 0.618 |
MLK4 |
0.785 | -0.051 | 2 | 0.650 |
DCAMKL2 |
0.785 | 0.074 | -3 | 0.864 |
DNAPK |
0.785 | 0.151 | 1 | 0.836 |
GRK7 |
0.785 | 0.009 | 1 | 0.755 |
PKCB |
0.784 | -0.012 | 2 | 0.630 |
PAK2 |
0.784 | -0.018 | -2 | 0.723 |
MSK2 |
0.784 | -0.006 | -3 | 0.780 |
CAMK1A |
0.784 | 0.176 | -3 | 0.726 |
PAK6 |
0.784 | 0.036 | -2 | 0.672 |
RSK4 |
0.784 | 0.010 | -3 | 0.785 |
QSK |
0.784 | 0.030 | 4 | 0.778 |
PERK |
0.784 | -0.004 | -2 | 0.842 |
ACVR2B |
0.784 | 0.007 | -2 | 0.823 |
BCKDK |
0.783 | -0.145 | -1 | 0.771 |
IRAK4 |
0.783 | 0.015 | 1 | 0.795 |
PKCA |
0.783 | -0.022 | 2 | 0.632 |
MAPKAPK5 |
0.783 | 0.030 | -3 | 0.751 |
CLK1 |
0.782 | 0.048 | -3 | 0.806 |
CDK8 |
0.782 | -0.025 | 1 | 0.613 |
SNRK |
0.782 | -0.043 | 2 | 0.683 |
SRPK3 |
0.782 | 0.002 | -3 | 0.763 |
HRI |
0.782 | -0.022 | -2 | 0.838 |
BRSK1 |
0.782 | -0.002 | -3 | 0.840 |
BRSK2 |
0.782 | -0.005 | -3 | 0.857 |
PKCH |
0.782 | -0.018 | 2 | 0.651 |
VRK2 |
0.782 | -0.090 | 1 | 0.834 |
CLK4 |
0.782 | 0.027 | -3 | 0.821 |
CHAK1 |
0.782 | -0.071 | 2 | 0.670 |
CDK2 |
0.781 | 0.024 | 1 | 0.676 |
PKG2 |
0.781 | 0.012 | -2 | 0.630 |
BMPR1A |
0.781 | 0.056 | 1 | 0.714 |
P38A |
0.781 | 0.017 | 1 | 0.648 |
AKT2 |
0.781 | 0.035 | -3 | 0.748 |
PKCG |
0.780 | -0.047 | 2 | 0.631 |
MARK2 |
0.780 | 0.024 | 4 | 0.699 |
CDK5 |
0.780 | -0.005 | 1 | 0.665 |
JNK2 |
0.780 | 0.020 | 1 | 0.559 |
MSK1 |
0.780 | 0.013 | -3 | 0.789 |
MEK1 |
0.780 | -0.126 | 2 | 0.736 |
ERK2 |
0.780 | 0.005 | 1 | 0.622 |
CHK2 |
0.779 | 0.128 | -3 | 0.706 |
PLK3 |
0.779 | -0.047 | 2 | 0.667 |
PKCZ |
0.779 | -0.040 | 2 | 0.682 |
CDK7 |
0.779 | -0.031 | 1 | 0.633 |
DYRK2 |
0.779 | -0.009 | 1 | 0.650 |
PKACB |
0.778 | 0.011 | -2 | 0.627 |
TLK2 |
0.778 | -0.030 | 1 | 0.824 |
SGK3 |
0.778 | 0.011 | -3 | 0.810 |
PHKG2 |
0.778 | 0.031 | -3 | 0.858 |
SMMLCK |
0.777 | 0.028 | -3 | 0.850 |
CDK1 |
0.777 | -0.002 | 1 | 0.589 |
WNK4 |
0.777 | -0.016 | -2 | 0.786 |
JNK3 |
0.776 | -0.009 | 1 | 0.607 |
BRAF |
0.776 | -0.065 | -4 | 0.774 |
MARK3 |
0.776 | 0.008 | 4 | 0.733 |
PINK1 |
0.776 | -0.063 | 1 | 0.822 |
TLK1 |
0.776 | 0.000 | -2 | 0.828 |
AURA |
0.776 | -0.008 | -2 | 0.602 |
P70S6K |
0.776 | 0.002 | -3 | 0.753 |
MARK1 |
0.775 | 0.009 | 4 | 0.758 |
CDK18 |
0.775 | 0.001 | 1 | 0.574 |
PLK4 |
0.775 | -0.069 | 2 | 0.658 |
AKT1 |
0.775 | 0.044 | -3 | 0.767 |
NEK2 |
0.774 | -0.109 | 2 | 0.702 |
CDK19 |
0.774 | -0.027 | 1 | 0.573 |
P38B |
0.774 | 0.008 | 1 | 0.579 |
DAPK3 |
0.774 | 0.073 | -3 | 0.851 |
CDK14 |
0.774 | 0.030 | 1 | 0.612 |
DYRK1A |
0.774 | 0.017 | 1 | 0.697 |
YSK4 |
0.774 | -0.159 | 1 | 0.700 |
GRK2 |
0.773 | -0.059 | -2 | 0.725 |
IRAK1 |
0.773 | -0.061 | -1 | 0.739 |
PRKX |
0.772 | 0.023 | -3 | 0.752 |
NEK5 |
0.772 | -0.045 | 1 | 0.821 |
ERK1 |
0.772 | -0.008 | 1 | 0.563 |
MEKK2 |
0.771 | -0.086 | 2 | 0.730 |
CDK17 |
0.771 | -0.011 | 1 | 0.518 |
MEKK3 |
0.771 | -0.126 | 1 | 0.723 |
P38G |
0.771 | -0.013 | 1 | 0.498 |
MEK5 |
0.770 | -0.166 | 2 | 0.734 |
CDK16 |
0.770 | 0.024 | 1 | 0.547 |
GAK |
0.770 | 0.015 | 1 | 0.826 |
PKCT |
0.770 | -0.024 | 2 | 0.658 |
P38D |
0.769 | 0.024 | 1 | 0.548 |
PRP4 |
0.769 | -0.030 | -3 | 0.730 |
MRCKA |
0.769 | 0.056 | -3 | 0.813 |
HIPK1 |
0.769 | -0.007 | 1 | 0.667 |
DRAK1 |
0.769 | -0.093 | 1 | 0.692 |
ZAK |
0.768 | -0.126 | 1 | 0.701 |
NEK8 |
0.768 | -0.070 | 2 | 0.728 |
CDK13 |
0.768 | -0.049 | 1 | 0.609 |
CAMKK1 |
0.768 | -0.068 | -2 | 0.801 |
MPSK1 |
0.767 | -0.018 | 1 | 0.777 |
CDK3 |
0.767 | 0.027 | 1 | 0.538 |
PASK |
0.767 | -0.038 | -3 | 0.872 |
PKN1 |
0.767 | 0.055 | -3 | 0.775 |
CK1E |
0.766 | -0.013 | -3 | 0.604 |
TTBK1 |
0.766 | -0.087 | 2 | 0.561 |
CLK2 |
0.766 | 0.012 | -3 | 0.810 |
MEKK1 |
0.766 | -0.187 | 1 | 0.761 |
PKACA |
0.766 | 0.012 | -2 | 0.583 |
EEF2K |
0.765 | 0.001 | 3 | 0.831 |
HIPK3 |
0.765 | -0.009 | 1 | 0.650 |
DAPK1 |
0.765 | 0.045 | -3 | 0.832 |
PKCI |
0.763 | -0.025 | 2 | 0.651 |
HIPK2 |
0.763 | -0.014 | 1 | 0.565 |
CDK10 |
0.763 | -0.005 | 1 | 0.599 |
PKCE |
0.763 | 0.003 | 2 | 0.625 |
PAK5 |
0.762 | -0.019 | -2 | 0.611 |
MST3 |
0.762 | -0.092 | 2 | 0.690 |
TAO2 |
0.762 | -0.074 | 2 | 0.728 |
CK1D |
0.762 | 0.000 | -3 | 0.554 |
TAO3 |
0.762 | -0.105 | 1 | 0.736 |
SBK |
0.761 | 0.079 | -3 | 0.641 |
MRCKB |
0.761 | 0.024 | -3 | 0.796 |
DYRK3 |
0.761 | -0.001 | 1 | 0.666 |
DYRK1B |
0.761 | -0.022 | 1 | 0.610 |
ERK7 |
0.761 | -0.030 | 2 | 0.436 |
CDK9 |
0.760 | -0.063 | 1 | 0.610 |
GRK3 |
0.760 | -0.051 | -2 | 0.681 |
CDK12 |
0.760 | -0.049 | 1 | 0.576 |
CDK6 |
0.759 | 0.003 | 1 | 0.591 |
LKB1 |
0.759 | -0.096 | -3 | 0.814 |
ROCK2 |
0.759 | 0.021 | -3 | 0.836 |
CK1A2 |
0.758 | -0.010 | -3 | 0.559 |
CAMKK2 |
0.757 | -0.118 | -2 | 0.794 |
PAK4 |
0.757 | -0.026 | -2 | 0.623 |
TAK1 |
0.757 | -0.068 | 1 | 0.785 |
PDK1 |
0.756 | -0.099 | 1 | 0.740 |
DMPK1 |
0.756 | 0.053 | -3 | 0.829 |
PLK2 |
0.756 | -0.017 | -3 | 0.813 |
CK2A2 |
0.756 | 0.002 | 1 | 0.654 |
DYRK4 |
0.756 | -0.027 | 1 | 0.573 |
NEK4 |
0.756 | -0.096 | 1 | 0.755 |
MEKK6 |
0.756 | -0.088 | 1 | 0.736 |
AKT3 |
0.756 | 0.016 | -3 | 0.686 |
NEK11 |
0.756 | -0.176 | 1 | 0.714 |
SGK1 |
0.756 | 0.018 | -3 | 0.671 |
CDK4 |
0.756 | -0.007 | 1 | 0.575 |
TTK |
0.755 | 0.043 | -2 | 0.817 |
VRK1 |
0.755 | -0.072 | 2 | 0.782 |
LRRK2 |
0.754 | -0.102 | 2 | 0.736 |
TNIK |
0.754 | -0.054 | 3 | 0.849 |
NEK1 |
0.754 | -0.041 | 1 | 0.775 |
MST2 |
0.754 | -0.105 | 1 | 0.740 |
JNK1 |
0.754 | -0.020 | 1 | 0.564 |
GSK3B |
0.753 | -0.060 | 4 | 0.329 |
HGK |
0.753 | -0.080 | 3 | 0.844 |
BIKE |
0.752 | 0.078 | 1 | 0.722 |
LOK |
0.752 | -0.076 | -2 | 0.747 |
CK1G1 |
0.752 | -0.051 | -3 | 0.598 |
CRIK |
0.752 | 0.037 | -3 | 0.757 |
MINK |
0.751 | -0.098 | 1 | 0.720 |
PBK |
0.750 | -0.010 | 1 | 0.762 |
MAP3K15 |
0.750 | -0.130 | 1 | 0.691 |
GCK |
0.749 | -0.124 | 1 | 0.721 |
GSK3A |
0.749 | -0.062 | 4 | 0.341 |
RIPK2 |
0.749 | -0.108 | 1 | 0.654 |
ROCK1 |
0.749 | 0.019 | -3 | 0.811 |
MOK |
0.748 | 0.006 | 1 | 0.690 |
MST1 |
0.748 | -0.106 | 1 | 0.727 |
PKG1 |
0.747 | -0.005 | -2 | 0.557 |
MAK |
0.747 | 0.014 | -2 | 0.690 |
STK33 |
0.745 | -0.130 | 2 | 0.558 |
SLK |
0.744 | -0.101 | -2 | 0.695 |
CK2A1 |
0.743 | -0.024 | 1 | 0.626 |
HPK1 |
0.743 | -0.121 | 1 | 0.698 |
MEK2 |
0.742 | -0.184 | 2 | 0.740 |
YSK1 |
0.741 | -0.118 | 2 | 0.694 |
OSR1 |
0.741 | -0.080 | 2 | 0.698 |
KHS1 |
0.741 | -0.100 | 1 | 0.711 |
KHS2 |
0.741 | -0.069 | 1 | 0.722 |
AAK1 |
0.740 | 0.103 | 1 | 0.628 |
ALPHAK3 |
0.740 | -0.032 | -1 | 0.723 |
NEK3 |
0.738 | -0.125 | 1 | 0.700 |
PDHK3_TYR |
0.738 | 0.003 | 4 | 0.844 |
HASPIN |
0.737 | -0.030 | -1 | 0.635 |
MYO3B |
0.735 | -0.055 | 2 | 0.708 |
MYO3A |
0.733 | -0.075 | 1 | 0.741 |
TESK1_TYR |
0.732 | -0.086 | 3 | 0.865 |
YANK3 |
0.731 | -0.060 | 2 | 0.346 |
PDHK4_TYR |
0.731 | -0.048 | 2 | 0.745 |
ASK1 |
0.730 | -0.128 | 1 | 0.679 |
TYRO3 |
0.729 | 0.046 | 3 | 0.780 |
EPHA6 |
0.729 | 0.002 | -1 | 0.852 |
MAP2K4_TYR |
0.728 | -0.134 | -1 | 0.824 |
PINK1_TYR |
0.728 | -0.116 | 1 | 0.805 |
YES1 |
0.728 | 0.036 | -1 | 0.863 |
MAP2K6_TYR |
0.727 | -0.120 | -1 | 0.817 |
LIMK2_TYR |
0.727 | -0.038 | -3 | 0.887 |
EPHB4 |
0.727 | 0.020 | -1 | 0.866 |
MAP2K7_TYR |
0.726 | -0.204 | 2 | 0.751 |
PDHK1_TYR |
0.726 | -0.094 | -1 | 0.845 |
TAO1 |
0.726 | -0.103 | 1 | 0.655 |
RET |
0.726 | -0.043 | 1 | 0.768 |
ROS1 |
0.725 | 0.007 | 3 | 0.749 |
FER |
0.725 | 0.030 | 1 | 0.848 |
ABL2 |
0.725 | 0.022 | -1 | 0.824 |
PKMYT1_TYR |
0.725 | -0.153 | 3 | 0.827 |
BMPR2_TYR |
0.724 | -0.106 | -1 | 0.806 |
STLK3 |
0.723 | -0.134 | 1 | 0.678 |
TYK2 |
0.723 | -0.047 | 1 | 0.767 |
HCK |
0.723 | 0.054 | -1 | 0.844 |
MST1R |
0.723 | -0.033 | 3 | 0.781 |
ABL1 |
0.722 | 0.022 | -1 | 0.822 |
LCK |
0.721 | 0.047 | -1 | 0.835 |
FLT3 |
0.721 | 0.014 | 3 | 0.774 |
CSF1R |
0.721 | -0.037 | 3 | 0.764 |
TXK |
0.721 | 0.030 | 1 | 0.758 |
FGR |
0.720 | -0.032 | 1 | 0.810 |
LIMK1_TYR |
0.720 | -0.137 | 2 | 0.756 |
BLK |
0.719 | 0.045 | -1 | 0.848 |
TEK |
0.719 | 0.009 | 3 | 0.727 |
TNK2 |
0.719 | 0.003 | 3 | 0.742 |
EPHB3 |
0.718 | 0.028 | -1 | 0.867 |
TEC |
0.718 | 0.067 | -1 | 0.811 |
INSRR |
0.718 | -0.032 | 3 | 0.730 |
SRMS |
0.718 | 0.007 | 1 | 0.804 |
EPHB1 |
0.718 | 0.022 | 1 | 0.784 |
EPHB2 |
0.717 | 0.024 | -1 | 0.859 |
MERTK |
0.717 | 0.047 | 3 | 0.753 |
JAK2 |
0.717 | -0.071 | 1 | 0.748 |
ITK |
0.716 | -0.019 | -1 | 0.821 |
AXL |
0.716 | 0.012 | 3 | 0.760 |
DDR1 |
0.716 | -0.115 | 4 | 0.774 |
FRK |
0.716 | 0.071 | -1 | 0.875 |
EPHA4 |
0.715 | -0.024 | 2 | 0.651 |
FGFR2 |
0.715 | -0.067 | 3 | 0.778 |
PDGFRB |
0.715 | -0.067 | 3 | 0.783 |
JAK3 |
0.714 | -0.085 | 1 | 0.736 |
BTK |
0.714 | 0.008 | -1 | 0.817 |
CK1A |
0.714 | -0.053 | -3 | 0.469 |
KDR |
0.714 | -0.043 | 3 | 0.737 |
PDGFRA |
0.714 | -0.019 | 3 | 0.782 |
KIT |
0.713 | -0.063 | 3 | 0.772 |
LTK |
0.712 | 0.008 | 3 | 0.714 |
FYN |
0.712 | 0.031 | -1 | 0.804 |
ALK |
0.712 | 0.000 | 3 | 0.694 |
BMX |
0.712 | 0.016 | -1 | 0.761 |
TNK1 |
0.712 | -0.042 | 3 | 0.749 |
FGFR1 |
0.712 | -0.061 | 3 | 0.751 |
PTK6 |
0.712 | -0.013 | -1 | 0.751 |
CK1G3 |
0.709 | -0.029 | -3 | 0.423 |
WEE1_TYR |
0.709 | -0.024 | -1 | 0.734 |
LYN |
0.708 | 0.016 | 3 | 0.693 |
EPHA1 |
0.708 | 0.018 | 3 | 0.736 |
EPHA7 |
0.707 | -0.019 | 2 | 0.668 |
EPHA3 |
0.706 | -0.038 | 2 | 0.648 |
MET |
0.706 | -0.083 | 3 | 0.758 |
TNNI3K_TYR |
0.706 | -0.071 | 1 | 0.749 |
ERBB2 |
0.705 | -0.064 | 1 | 0.729 |
PTK2B |
0.705 | 0.011 | -1 | 0.826 |
EPHA5 |
0.705 | 0.003 | 2 | 0.654 |
FGFR3 |
0.704 | -0.080 | 3 | 0.753 |
NEK10_TYR |
0.703 | -0.117 | 1 | 0.636 |
FLT4 |
0.703 | -0.081 | 3 | 0.732 |
NTRK1 |
0.703 | -0.092 | -1 | 0.810 |
NTRK2 |
0.703 | -0.082 | 3 | 0.746 |
JAK1 |
0.702 | -0.073 | 1 | 0.674 |
SRC |
0.702 | -0.008 | -1 | 0.820 |
INSR |
0.700 | -0.079 | 3 | 0.700 |
MATK |
0.700 | -0.065 | -1 | 0.740 |
YANK2 |
0.700 | -0.079 | 2 | 0.361 |
FLT1 |
0.699 | -0.118 | -1 | 0.801 |
EPHA8 |
0.698 | -0.035 | -1 | 0.831 |
EGFR |
0.697 | -0.037 | 1 | 0.640 |
NTRK3 |
0.693 | -0.093 | -1 | 0.767 |
CSK |
0.693 | -0.075 | 2 | 0.680 |
MUSK |
0.693 | -0.032 | 1 | 0.644 |
DDR2 |
0.692 | -0.081 | 3 | 0.720 |
SYK |
0.692 | -0.018 | -1 | 0.738 |
FGFR4 |
0.691 | -0.073 | -1 | 0.771 |
PTK2 |
0.689 | -0.048 | -1 | 0.742 |
IGF1R |
0.686 | -0.077 | 3 | 0.647 |
EPHA2 |
0.686 | -0.056 | -1 | 0.794 |
ERBB4 |
0.684 | -0.035 | 1 | 0.659 |
CK1G2 |
0.681 | -0.067 | -3 | 0.518 |
FES |
0.680 | -0.040 | -1 | 0.735 |
ZAP70 |
0.667 | -0.058 | -1 | 0.644 |