Motif 725 (n=186)

Position-wise Probabilities
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uniprot genes site source protein function
A6NI79 CCDC69 S241 ochoa Coiled-coil domain-containing protein 69 May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone. {ECO:0000305|PubMed:20962590}.
A6NKD9 CCDC85C S258 ochoa Coiled-coil domain-containing protein 85C May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}.
F8WAN1 SPECC1L-ADORA2A S171 ochoa SPECC1L-ADORA2A readthrough (NMD candidate) None
O00515 LAD1 S392 ochoa Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}.
O43752 STX6 S127 ochoa Syntaxin-6 SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. {ECO:0000250|UniProtKB:Q63635}.
O43900 PRICKLE3 S413 ochoa Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}.
O43933 PEX1 S1172 ochoa Peroxisomal ATPase PEX1 (EC 3.6.4.-) (Peroxin-1) (Peroxisome biogenesis disorder protein 1) (Peroxisome biogenesis factor 1) Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:11439091, PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29884772). {ECO:0000269|PubMed:11439091, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118, ECO:0000269|PubMed:29884772}.
O60566 BUB1B S714 ochoa Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}.
O60716 CTNND1 S713 ochoa Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}.
O75348 ATP6V1G1 S68 ochoa V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16) Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}.
O75528 TADA3 S330 ochoa Transcriptional adapter 3 (ADA3 homolog) (hADA3) (STAF54) (Transcriptional adapter 3-like) (ADA3-like protein) Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:11707411, ECO:0000269|PubMed:19103755}.
O75874 IDH1 S389 ochoa Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity). {ECO:0000250|UniProtKB:Q9XSG3, ECO:0000269|PubMed:10521434, ECO:0000269|PubMed:19935646, ECO:0000303|PubMed:10521434}.
O75899 GABBR2 S793 ochoa Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:9872744). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:22660477, PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). {ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10328880, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:18165688, ECO:0000269|PubMed:22660477, ECO:0000269|PubMed:24305054, ECO:0000269|PubMed:9872316, ECO:0000269|PubMed:9872744, ECO:0000305}.
O95232 LUC7L3 S116 ochoa Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}.
O95602 POLR1A S1265 ochoa DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene clusters, giving rise to 5.8S, 18S and 28S ribosomal RNAs (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Pol I-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol I pre-initiation complex (PIC) is recruited by the selectivity factor 1 (SL1/TIF-IB) complex bound to the core promoter that precedes an rDNA repeat unit. The PIC assembly bends the promoter favoring the formation of the transcription bubble and promoter escape. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Highly processive, assembles in structures referred to as 'Miller trees' where many elongating Pol I complexes queue and transcribe the same rDNA coding regions. At terminator sequences downstream of the rDNA gene, PTRF interacts with Pol I and halts Pol I transcription leading to the release of the RNA transcript and polymerase from the DNA (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Forms Pol I active center together with the second largest subunit POLR1B/RPA2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR1A/RPA1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR1B/RPA2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and the template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. Has proofreading activity: Pauses and backtracks to allow the cleavage of a missincorporated nucleotide via POLR1H/RPA12. High Pol I processivity is associated with decreased transcription fidelity (By similarity) (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). {ECO:0000250|UniProtKB:P10964, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.
P01241 GH1 S134 psp Somatotropin (Growth hormone) (GH) (GH-N) (Growth hormone 1) (Pituitary growth hormone) Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
P04899 GNAI2 S144 psp Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}.
P09874 PARP1 S179 ochoa|psp Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}.
P0C0S8 H2AC11 S19 ochoa Histone H2A type 1 (H2A.1) (Histone H2A/ptl) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P11055 MYH3 S643 ochoa Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) Muscle contraction.
P11532 DMD S3490 ochoa|psp Dystrophin Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}.
P12268 IMPDH2 S159 ochoa Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}.
P12882 MYH1 S646 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 S642 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12883 MYH7 S1275 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13010 XRCC5 S712 ochoa X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}.
P13533 MYH6 S644 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13535 MYH8 S645 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P13796 LCP1 S474 ochoa Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}.
P16104 H2AX S19 ochoa Histone H2AX (H2a/x) (Histone H2A.X) Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:26438602}.
P19532 TFE3 S321 psp Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:24448649). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:24448649, PubMed:31672913, PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:24448649, PubMed:31672913, PubMed:36608670). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:24448649). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (By similarity). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}.
P20671 H2AC7 S19 ochoa Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P22090 RPS4Y1 S32 ochoa Small ribosomal subunit protein eS4, Y isoform 1 (40S ribosomal protein S4) None
P27815 PDE4A S567 ochoa 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}.
P30622 CLIP1 S348 ochoa CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.
P31689 DNAJA1 S112 ochoa DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.
P32298 GRK4 S244 psp G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}.
P33176 KIF5B S819 ochoa Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}.
P33527 ABCC1 S961 psp Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231). {ECO:0000250|UniProtKB:O35379, ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:9281595, ECO:0000269|PubMed:9426231}.
P34910 EVI2B S271 ochoa Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}.
P38646 HSPA9 S212 ochoa Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}.
P39748 FEN1 S210 ochoa Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}.
P42356 PI4KA S761 ochoa Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}.
P49327 FASN S1481 ochoa Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}.
P51810 GPR143 S23 ochoa G-protein coupled receptor 143 (Ocular albinism type 1 protein) Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. {ECO:0000269|PubMed:10471510, ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:18697795, ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:19717472}.
P54868 HMGCS2 S325 ochoa Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. {ECO:0000269|PubMed:11228257, ECO:0000269|PubMed:23751782, ECO:0000269|PubMed:29597274}.
P54886 ALDH18A1 S79 ochoa Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. {ECO:0000269|PubMed:10037775, ECO:0000269|PubMed:11092761, ECO:0000269|PubMed:26297558, ECO:0000269|PubMed:26320891, ECO:0000269|PubMed:39506109}.
P55017 SLC12A3 S73 psp Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter) Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:18270262, PubMed:21613606, PubMed:22009145, PubMed:36351028, PubMed:36792826). Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity). May act either independently of IL18R1, or in a complex with IL18R1 (By similarity). {ECO:0000250|UniProtKB:P59158, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22009145, ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826}.
P62701 RPS4X S32 ochoa Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein) Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.
P82094 TMF1 S542 ochoa TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}.
Q03252 LMNB2 S168 ochoa Lamin-B2 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}.
Q04864 REL S503 psp Proto-oncogene c-Rel Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
Q08378 GOLGA3 S1213 ochoa Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) Golgi auto-antigen; probably involved in maintaining Golgi structure.
Q0IIM8 TBC1D8B S539 ochoa TBC1 domain family member 8B Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein. {ECO:0000269|PubMed:30661770}.
Q12955 ANK3 S531 ochoa Ankyrin-3 (ANK-3) (Ankyrin-G) Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}.
Q13136 PPFIA1 S77 ochoa Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.
Q13136 PPFIA1 S547 ochoa Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.
Q13393 PLD1 S519 ochoa Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}.
Q14192 FHL2 S255 ochoa Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}.
Q14318 FKBP8 S358 ochoa Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796, ECO:0000269|PubMed:28169297}.
Q14457 BECN1 S30 psp Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). May play a role in antiviral host defense. {ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23974797, ECO:0000269|PubMed:25275521, ECO:0000269|PubMed:25484083, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:37776275, ECO:0000269|PubMed:9765397}.; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. {ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:26263979}.; FUNCTION: (Microbial infection) Protects against infection by a neurovirulent strain of Sindbis virus. {ECO:0000269|PubMed:9765397}.
Q14457 BECN1 S96 psp Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). May play a role in antiviral host defense. {ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23974797, ECO:0000269|PubMed:25275521, ECO:0000269|PubMed:25484083, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:37776275, ECO:0000269|PubMed:9765397}.; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. {ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:26263979}.; FUNCTION: (Microbial infection) Protects against infection by a neurovirulent strain of Sindbis virus. {ECO:0000269|PubMed:9765397}.
Q14566 MCM6 S268 ochoa DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
Q14692 BMS1 S558 ochoa Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}.
Q14789 GOLGB1 S560 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q15743 GPR68 S328 ochoa G-protein coupled receptor 68 (G-protein coupled receptor 12A) (GPR12A) (Ovarian cancer G-protein coupled receptor 1) (OGR-1) Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed:33478938, PubMed:39753132). The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:29677517, PubMed:39753132). GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:29677517, PubMed:39753132). Acts as a key mechanosensor of fluid shear stress and membrane stretch (PubMed:29677517, PubMed:30471999). Expressed in endothelial cells of small-diameter resistance arteries, where it mediates flow-induced dilation in response to shear stress (PubMed:29677517). May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone (By similarity). Acts as a regulator of calcium-sensing receptor CASR in a seesaw manner: GPR68-mediated signaling inhibits CASR signaling in response to protons, while CASR inhibits GPR68 in presence of extracellular calcium (By similarity). {ECO:0000250|UniProtKB:Q8BFQ3, ECO:0000269|PubMed:12955148, ECO:0000269|PubMed:29677517, ECO:0000269|PubMed:30471999, ECO:0000269|PubMed:32865988, ECO:0000269|PubMed:33478938, ECO:0000269|PubMed:39753132}.
Q15746 MYLK S1151 ochoa Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}.
Q16777 H2AC20 S19 ochoa Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q16825 PTPN21 S637 ochoa Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) None
Q16891 IMMT S190 ochoa MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
Q3KQU3 MAP7D1 S811 ochoa MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}.
Q4VCS5 AMOT S538 psp Angiomotin Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}.
Q53GL7 PARP10 S663 ochoa Protein mono-ADP-ribosyltransferase PARP10 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) (Poly [ADP-ribose] polymerase 10) (PARP-10) ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737). {ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:23332125, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:24695737, ECO:0000269|PubMed:25043379}.
Q5SW79 CEP170 S463 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5T200 ZC3H13 S1386 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5VTQ0 TTC39B S127 ochoa Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3). {ECO:0000250|UniProtKB:Q8BYY4}.
Q5VV41 ARHGEF16 S129 ochoa Rho guanine nucleotide exchange factor 16 (Ephexin-4) Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}.
Q63HN8 RNF213 S926 ochoa E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}.
Q69YQ0 SPECC1L S171 ochoa Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}.
Q6FI13 H2AC18 S19 ochoa Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q6P5Z2 PKN3 S171 ochoa Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}.
Q6WCQ1 MPRIP S663 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q6ZMU5 TRIM72 S189 ochoa Tripartite motif-containing protein 72 (EC 2.3.2.27) (Mitsugumin-53) (Mg53) Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (PubMed:36944613). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (By similarity). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (By similarity). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (By similarity). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity). Required for transport of DYSF to sites of cell injury during repair patch formation (By similarity). Regulates membrane budding and exocytosis (By similarity). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). {ECO:0000250|UniProtKB:Q1XH17, ECO:0000269|PubMed:36944613}.
Q6ZN55 ZNF574 S312 ochoa Zinc finger protein 574 May be involved in transcriptional regulation.
Q6ZU35 CRACD S1072 ochoa Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}.
Q6ZWB6 KCTD8 S255 ochoa BTB/POZ domain-containing protein KCTD8 Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.
Q7Z3B3 KANSL1 S115 ochoa KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}.
Q7Z7A1 CNTRL S1103 ochoa Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. {ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:16213214}.
Q7Z7A1 CNTRL S1475 ochoa Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. {ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:16213214}.
Q86UU1 PHLDB1 S188 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86VQ1 GLCCI1 S221 ochoa Glucocorticoid-induced transcript 1 protein None
Q86WV6 STING1 S358 psp Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23747010, PubMed:23910378, PubMed:27801882, PubMed:29973723, PubMed:30842659, PubMed:35045565, PubMed:35388221, PubMed:36808561, PubMed:37832545, PubMed:25704810, PubMed:39255680). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed:26300263). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, cyclic UMP-AMP (2',3'-cUAMP), and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (PubMed:21947006, PubMed:23258412, PubMed:23707065, PubMed:23722158, PubMed:23747010, PubMed:23910378, PubMed:26229117, PubMed:30842659, PubMed:35388221, PubMed:37379839). Upon binding to c-di-GMP, cUAMP or cGAMP, STING1 oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state (PubMed:22394562, PubMed:25636800, PubMed:29973723, PubMed:30842653, PubMed:35045565, PubMed:35388221). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:23747010, PubMed:23910378, PubMed:26300263). The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free-ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation (PubMed:26150511). In addition to promote the production of type I interferons, plays a direct role in autophagy (PubMed:30568238, PubMed:30842662). Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (PubMed:30842662). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (PubMed:30842662). Promotes autophagy by acting as a proton channel that directs proton efflux from the Golgi to facilitate MAP1LC3B/LC3B lipidation (PubMed:37535724). The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (PubMed:30568238, PubMed:30842662). Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy (By similarity). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons (PubMed:18724357). May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) (By similarity). {ECO:0000250|UniProtKB:Q3TBT3, ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:19776740, ECO:0000269|PubMed:21947006, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:23258412, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722158, ECO:0000269|PubMed:23747010, ECO:0000269|PubMed:23910378, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:26150511, ECO:0000269|PubMed:26229117, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29973723, ECO:0000269|PubMed:30568238, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:30842659, ECO:0000269|PubMed:30842662, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35388221, ECO:0000269|PubMed:36808561, ECO:0000269|PubMed:37379839, ECO:0000269|PubMed:37535724, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:39255680}.; FUNCTION: (Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed:26405230). Such oncoproteins prevent the ability to sense cytosolic DNA (PubMed:26405230). {ECO:0000269|PubMed:26405230}.
Q86XI2 NCAPG2 S30 ochoa Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (hCAP-G2) (Leucine zipper protein 5) (Non-SMC condensin II complex subunit G2) Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:30609410}.
Q8IUE6 H2AC21 S19 ochoa Histone H2A type 2-B (H2A-clustered histone 21) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q8IXK0 PHC2 S590 ochoa Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Q8IXS8 HYCC2 S491 ochoa Hyccin 2 Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}.
Q8IXW5 RPAP2 S350 ochoa Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600, ECO:0000269|PubMed:30118681}.
Q8IYD8 FANCM S52 ochoa Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}.
Q8IYJ3 SYTL1 S216 ochoa Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}.
Q8N3C7 CLIP4 S607 ochoa CAP-Gly domain-containing linker protein 4 (Restin-like protein 2) None
Q8N4N8 KIF2B S643 psp Kinesin-like protein KIF2B Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}.
Q8NC44 RETREG2 S337 ochoa Reticulophagy regulator 2 Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}.
Q8NCF5 NFATC2IP S345 ochoa NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}.
Q8NER1 TRPV1 S117 psp Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:11050376, PubMed:11243859, PubMed:11226139, PubMed:12077606). Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activated by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius (PubMed:37117175). Upon activation, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. {ECO:0000250|UniProtKB:O35433, ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11226139, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:37117175}.
Q8TAE8 GADD45GIP1 Y166 ochoa Large ribosomal subunit protein mL64 (39S ribosomal protein L59, mitochondrial) (MRP-L59) (CKII beta-associating protein) (CR6-interacting factor 1) (CRIF1) (Growth arrest and DNA damage-inducible proteins-interacting protein 1) (Papillomavirus L2-interacting nuclear protein 1) (PLINP) (PLINP-1) (p53-responsive gene 6 protein) Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Q8WU20 FRS2 S339 ochoa Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}.
Q8WW22 DNAJA4 S113 ochoa DnaJ homolog subfamily A member 4 None
Q92622 RUBCN S946 ochoa Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}.
Q92750 TAF4B S314 ochoa Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105) Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}.
Q92888 ARHGEF1 S267 ochoa Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}.
Q92974 ARHGEF2 S151 ochoa|psp Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}.
Q93077 H2AC6 S19 ochoa Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q969G5 CAVIN3 S62 ochoa Caveolae-associated protein 3 (Cavin-3) (Protein kinase C delta-binding protein) (Serum deprivation response factor-related gene product that binds to C-kinase) (hSRBC) Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). {ECO:0000250|UniProtKB:Q91VJ2, ECO:0000250|UniProtKB:Q9Z1H9, ECO:0000269|PubMed:19262564}.
Q96A65 EXOC4 S226 ochoa Exocyst complex component 4 (Exocyst complex component Sec8) Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}.
Q96AP0 ACD S169 psp Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein) Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. {ECO:0000269|PubMed:15181449, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378, ECO:0000269|PubMed:17237768, ECO:0000269|PubMed:20231318, ECO:0000269|PubMed:25205116, ECO:0000269|PubMed:25233904}.
Q96CW1 AP2M1 S153 ochoa AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein) Component of the adaptor protein complex 2 (AP-2) (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed:16581796). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (By similarity). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (PubMed:19033387). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (By similarity). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed:11877457). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (PubMed:11877457). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P84092, ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:12694563, ECO:0000269|PubMed:12952941, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:16581796, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:31104773}.
Q96CX2 KCTD12 S256 ochoa BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.
Q96EY1 DNAJA3 S23 ochoa DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog) Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Q96FL8 SLC47A1 S23 ochoa Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1) Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16330770, PubMed:17509534). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:17582384, ECO:0000269|PubMed:18305230, ECO:0000269|PubMed:19158817, ECO:0000269|PubMed:21128598, ECO:0000269|PubMed:24961373, ECO:0000305|PubMed:35307651}.
Q96KK5 H2AC12 S19 ochoa Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q96QT4 TRPM7 S1258 psp Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}.
Q96RL1 UIMC1 S430 ochoa BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}.
Q96SN8 CDK5RAP2 S1389 ochoa CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}.
Q96T58 SPEN S2634 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99459 CDC5L S460 ochoa Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}.
Q99878 H2AC14 S19 ochoa Histone H2A type 1-J (Histone H2A/e) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q99959 PKP2 S132 ochoa Plakophilin-2 A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}.
Q9BRP8 PYM1 S177 ochoa Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}.
Q9BSJ8 ESYT1 S860 ochoa Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}.
Q9BXB4 OSBPL11 S286 ochoa Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:23028956, ECO:0000269|PubMed:39106189}.
Q9BY89 KIAA1671 S1264 ochoa Uncharacterized protein KIAA1671 None
Q9BYX2 TBC1D2 S295 ochoa TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}.
Q9BZ29 DOCK9 S32 ochoa Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}.
Q9BZF1 OSBPL8 S120 ochoa Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}.
Q9C0C2 TNKS1BP1 S1418 ochoa 182 kDa tankyrase-1-binding protein None
Q9H1A4 ANAPC1 S60 ochoa Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9H582 ZNF644 S253 ochoa Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) May be involved in transcriptional regulation.
Q9H5N1 RABEP2 S27 ochoa Rab GTPase-binding effector protein 2 (Rabaptin-5beta) Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062). {ECO:0000269|PubMed:27224062, ECO:0000269|PubMed:29425100, ECO:0000269|PubMed:9524116}.
Q9H611 PIF1 S199 ochoa ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721, ECO:0000269|PubMed:18835853, ECO:0000269|PubMed:19700773, ECO:0000269|PubMed:20524933, ECO:0000269|PubMed:23657261}.
Q9H8G2 CAAP1 S94 ochoa Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}.
Q9H981 ACTR8 S446 ochoa Actin-related protein 8 (hArp8) (INO80 complex subunit N) Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.
Q9NPG3 UBN1 S764 ochoa Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}.
Q9NRS6 SNX15 S116 ochoa Sorting nexin-15 May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. {ECO:0000269|PubMed:11085978}.
Q9NS87 KIF15 S1083 ochoa Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}.
Q9NX63 CHCHD3 S50 ochoa MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
Q9NYQ7 CELSR3 S3064 ochoa Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) Receptor that may have an important role in cell/cell signaling during nervous system formation.
Q9NZN4 EHD2 S373 ochoa EH domain-containing protein 2 (PAST homolog 2) ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833). {ECO:0000250|UniProtKB:Q8BH64, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:25588833}.
Q9P0V9 SEPTIN10 S25 ochoa Septin-10 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {ECO:0000305}.
Q9P107 GMIP S454 ochoa GEM-interacting protein (GMIP) Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}.
Q9P272 TRMT9B S255 ochoa Probable tRNA methyltransferase 9B (Probable tRNA methyltransferase 9-like protein) (EC 2.1.1.-) May modify wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9. {ECO:0000269|PubMed:23381944}.
Q9UDT6 CLIP2 S352 ochoa CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Q9UH65 SWAP70 S36 ochoa Switch-associated protein 70 (SWAP-70) Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250, ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}.
Q9UKA2 FBXL4 S267 ochoa F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5) Substrate-recognition component of the mitochondria-localized SCF-FBXL4 ubiquitin E3 ligase complex that plays a role in the restriction of mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors (PubMed:36896912, PubMed:38992176). Rescues also mitochondrial injury through reverting hyperactivation of DRP1-mediated mitochondrial fission (By similarity). {ECO:0000250|UniProtKB:Q8BH70, ECO:0000269|PubMed:36896912, ECO:0000269|PubMed:38992176}.
Q9UKI2 CDC42EP3 S144 ochoa Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein) Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}.
Q9UKX2 MYH2 S54 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX2 MYH2 S648 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UL54 TAOK2 S493 ochoa Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}.
Q9ULD6 INTU S450 ochoa Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). Required for recruitment of CPLANE2 to the mother centriole (By similarity). Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity). {ECO:0000250|UniProtKB:Q059U7, ECO:0000250|UniProtKB:Q2I0E5, ECO:0000305|PubMed:27158779}.
Q9ULL8 SHROOM4 S665 ochoa Protein Shroom4 (Second homolog of apical protein) Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}.
Q9UPT5 EXOC7 S283 ochoa Exocyst complex component 7 (Exocyst complex component Exo70) Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). It is required for neuron survival and plays an essential role in cortical development (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:E7FC72}.
Q9Y2X7 GIT1 S417 ochoa ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}.
Q9Y2Z4 YARS2 S376 ochoa Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). {ECO:0000269|PubMed:15779907, ECO:0000269|PubMed:17997975}.
Q9Y333 LSM2 S65 ochoa U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5) Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.
Q9Y490 TLN1 S834 ochoa Talin-1 High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}.
Q9Y490 TLN1 S1055 ochoa Talin-1 High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}.
Q9Y490 TLN1 S1143 ochoa Talin-1 High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}.
Q9Y4B4 RAD54L2 S1233 ochoa Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}.
Q9Y5K8 ATP6V1D S118 ochoa V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D) Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (PubMed:21844891). {ECO:0000250|UniProtKB:P39942, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:33065002}.
Q9Y5S2 CDC42BPB S481 ochoa|psp Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
Q9Y623 MYH4 S646 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
P49753 ACOT2 Y114 Sugiyama Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (Acyl-coenzyme A thioester hydrolase 2a) (CTE-Ia) (Long-chain acyl-CoA thioesterase 2) (ZAP128) Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10944470, PubMed:16940157). Displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:10944470, PubMed:16940157). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity). {ECO:0000250|UniProtKB:Q9QYR9, ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157}.
Q86TX2 ACOT1 Y52 Sugiyama Acyl-coenzyme A thioesterase 1 (Acyl-CoA thioesterase 1) (EC 3.1.2.-) (CTE-I) (CTE-Ib) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (Palmitoyl-coenzyme A thioesterase) (EC 3.1.2.2) Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20). {ECO:0000269|PubMed:16940157}.
P53675 CLTCL1 S460 Sugiyama Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.
Q00610 CLTC S460 Sugiyama Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
O14920 IKBKB S507 Sugiyama Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}.
Q96KP4 CNDP2 S194 Sugiyama Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) (Peptidase A) (Threonyl dipeptidase) Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity). Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity). Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (PubMed:12473676, PubMed:19346245). Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis (PubMed:25964343). Plays a role in the regulation of cell cycle arrest and apoptosis (PubMed:17121880, PubMed:24395568). {ECO:0000250|UniProtKB:Q9D1A2, ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880, ECO:0000269|PubMed:19346245, ECO:0000269|PubMed:24395568, ECO:0000269|PubMed:25964343}.
Q99798 ACO2 S388 Sugiyama Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}.
O94804 STK10 S875 Sugiyama Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}.
P08754 GNAI3 S143 Sugiyama Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}.
P26038 MSN S440 Sugiyama Moesin (Membrane-organizing extension spike protein) Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}.
Q9Y617 PSAT1 S43 Sugiyama Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}.
Q13621 SLC12A1 S122 SIGNOR Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (BSC1) (Kidney-specific Na-K-Cl symporter) (Na-K-2Cl cotransporter 2) (NKCC2) Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation (PubMed:21321328). Electrically silent transporter system (By similarity). {ECO:0000250|UniProtKB:P55014, ECO:0000250|UniProtKB:P55016, ECO:0000269|PubMed:21321328}.
Q13464 ROCK1 S576 Sugiyama Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}.
Q5S007 LRRK2 S2370 Sugiyama Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}.
Q8TF76 HASPIN S543 Sugiyama Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}.
Q00610 CLTC S432 Sugiyama Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
Download
reactome_id name p -log10_p
R-HSA-5689901 Metalloprotease DUBs 5.469191e-10 9.262
R-HSA-3214858 RMTs methylate histone arginines 3.465175e-08 7.460
R-HSA-171306 Packaging Of Telomere Ends 3.094896e-07 6.509
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 7.871164e-07 6.104
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 1.297034e-06 5.887
R-HSA-3214815 HDACs deacetylate histones 2.006878e-06 5.697
R-HSA-3214847 HATs acetylate histones 2.083711e-06 5.681
R-HSA-110331 Cleavage of the damaged purine 2.058493e-06 5.686
R-HSA-5689603 UCH proteinases 1.824213e-06 5.739
R-HSA-73927 Depurination 2.383280e-06 5.623
R-HSA-9670095 Inhibition of DNA recombination at telomere 3.162188e-06 5.500
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 4.319052e-06 5.365
R-HSA-110329 Cleavage of the damaged pyrimidine 4.720853e-06 5.326
R-HSA-73928 Depyrimidination 4.720853e-06 5.326
R-HSA-73728 RNA Polymerase I Promoter Opening 5.290360e-06 5.277
R-HSA-73884 Base Excision Repair 6.786125e-06 5.168
R-HSA-5334118 DNA methylation 7.371788e-06 5.132
R-HSA-2299718 Condensation of Prophase Chromosomes 7.748771e-06 5.111
R-HSA-5689880 Ub-specific processing proteases 9.043151e-06 5.044
R-HSA-157579 Telomere Maintenance 1.345134e-05 4.871
R-HSA-68616 Assembly of the ORC complex at the origin of replication 1.352349e-05 4.869
R-HSA-73772 RNA Polymerase I Promoter Escape 1.518532e-05 4.819
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 1.686518e-05 4.773
R-HSA-1221632 Meiotic synapsis 1.686518e-05 4.773
R-HSA-5688426 Deubiquitination 1.606131e-05 4.794
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 1.787218e-05 4.748
R-HSA-73929 Base-Excision Repair, AP Site Formation 1.869571e-05 4.728
R-HSA-212300 PRC2 methylates histones and DNA 2.328425e-05 4.633
R-HSA-427359 SIRT1 negatively regulates rRNA expression 2.644584e-05 4.578
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 3.805426e-05 4.420
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 4.272253e-05 4.369
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 4.272253e-05 4.369
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 5.668758e-05 4.247
R-HSA-9710421 Defective pyroptosis 5.954102e-05 4.225
R-HSA-2559583 Cellular Senescence 6.414774e-05 4.193
R-HSA-68867 Assembly of the pre-replicative complex 6.624523e-05 4.179
R-HSA-73886 Chromosome Maintenance 7.452265e-05 4.128
R-HSA-774815 Nucleosome assembly 7.342524e-05 4.134
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 7.342524e-05 4.134
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 8.489763e-05 4.071
R-HSA-427413 NoRC negatively regulates rRNA expression 8.489763e-05 4.071
R-HSA-73854 RNA Polymerase I Promoter Clearance 1.236285e-04 3.908
R-HSA-912446 Meiotic recombination 1.311321e-04 3.882
R-HSA-2559580 Oxidative Stress Induced Senescence 1.247040e-04 3.904
R-HSA-3247509 Chromatin modifying enzymes 1.303939e-04 3.885
R-HSA-73864 RNA Polymerase I Transcription 1.426661e-04 3.846
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 1.640141e-04 3.785
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 1.878771e-04 3.726
R-HSA-69002 DNA Replication Pre-Initiation 1.976118e-04 3.704
R-HSA-1500620 Meiosis 2.288616e-04 3.640
R-HSA-4839726 Chromatin organization 2.197596e-04 3.658
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 2.386223e-04 3.622
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 2.794627e-04 3.554
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 2.794627e-04 3.554
R-HSA-9616222 Transcriptional regulation of granulopoiesis 3.256007e-04 3.487
R-HSA-196025 Formation of annular gap junctions 4.184608e-04 3.378
R-HSA-2262752 Cellular responses to stress 4.143295e-04 3.383
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 4.057714e-04 3.392
R-HSA-69306 DNA Replication 4.218717e-04 3.375
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 5.005896e-04 3.301
R-HSA-190873 Gap junction degradation 5.381734e-04 3.269
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 5.728093e-04 3.242
R-HSA-9764560 Regulation of CDH1 Gene Transcription 5.728093e-04 3.242
R-HSA-5578749 Transcriptional regulation by small RNAs 6.528726e-04 3.185
R-HSA-9020591 Interleukin-12 signaling 8.388190e-04 3.076
R-HSA-8953897 Cellular responses to stimuli 1.087906e-03 2.963
R-HSA-977225 Amyloid fiber formation 1.125862e-03 2.949
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 1.330993e-03 2.876
R-HSA-73894 DNA Repair 1.418927e-03 2.848
R-HSA-447115 Interleukin-12 family signaling 1.647512e-03 2.783
R-HSA-9645723 Diseases of programmed cell death 1.734891e-03 2.761
R-HSA-390522 Striated Muscle Contraction 1.895687e-03 2.722
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 1.897447e-03 2.722
R-HSA-68875 Mitotic Prophase 1.903259e-03 2.721
R-HSA-2132295 MHC class II antigen presentation 2.152419e-03 2.667
R-HSA-9816359 Maternal to zygotic transition (MZT) 2.152419e-03 2.667
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 2.050800e-03 2.688
R-HSA-1912408 Pre-NOTCH Transcription and Translation 2.018227e-03 2.695
R-HSA-9610379 HCMV Late Events 2.109620e-03 2.676
R-HSA-68886 M Phase 2.360173e-03 2.627
R-HSA-1474165 Reproduction 3.053191e-03 2.515
R-HSA-9842860 Regulation of endogenous retroelements 3.666957e-03 2.436
R-HSA-9818025 NFE2L2 regulating TCA cycle genes 3.797353e-03 2.421
R-HSA-418990 Adherens junctions interactions 3.987757e-03 2.399
R-HSA-9764265 Regulation of CDH1 Expression and Function 3.688525e-03 2.433
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 3.688525e-03 2.433
R-HSA-5619507 Activation of HOX genes during differentiation 4.158744e-03 2.381
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 4.158744e-03 2.381
R-HSA-211000 Gene Silencing by RNA 4.697697e-03 2.328
R-HSA-5603029 IkBA variant leads to EDA-ID 4.918212e-03 2.308
R-HSA-9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... 5.883315e-03 2.230
R-HSA-1912422 Pre-NOTCH Expression and Processing 5.927491e-03 2.227
R-HSA-199991 Membrane Trafficking 6.193195e-03 2.208
R-HSA-1640170 Cell Cycle 6.525336e-03 2.185
R-HSA-426117 Cation-coupled Chloride cotransporters 7.556548e-03 2.122
R-HSA-9609690 HCMV Early Events 7.124830e-03 2.147
R-HSA-9609507 Protein localization 7.080615e-03 2.150
R-HSA-421270 Cell-cell junction organization 8.978692e-03 2.047
R-HSA-8949613 Cristae formation 9.192628e-03 2.037
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 9.192628e-03 2.037
R-HSA-264876 Insulin processing 9.192628e-03 2.037
R-HSA-69278 Cell Cycle, Mitotic 9.431622e-03 2.025
R-HSA-77387 Insulin receptor recycling 9.960758e-03 2.002
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 1.000864e-02 2.000
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 1.000864e-02 2.000
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 1.000864e-02 2.000
R-HSA-983189 Kinesins 1.201037e-02 1.920
R-HSA-9837999 Mitochondrial protein degradation 1.160575e-02 1.935
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 1.070033e-02 1.971
R-HSA-2682334 EPH-Ephrin signaling 1.074785e-02 1.969
R-HSA-9909648 Regulation of PD-L1(CD274) expression 1.243344e-02 1.905
R-HSA-9762292 Regulation of CDH11 function 1.245326e-02 1.905
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 1.245326e-02 1.905
R-HSA-1268020 Mitochondrial protein import 1.322506e-02 1.879
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 1.343512e-02 1.872
R-HSA-163765 ChREBP activates metabolic gene expression 1.432246e-02 1.844
R-HSA-9018519 Estrogen-dependent gene expression 1.490057e-02 1.827
R-HSA-446728 Cell junction organization 1.577954e-02 1.802
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 1.630471e-02 1.788
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 1.636761e-02 1.786
R-HSA-8866427 VLDLR internalisation and degradation 1.839686e-02 1.735
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 2.059578e-02 1.686
R-HSA-199992 trans-Golgi Network Vesicle Budding 2.046005e-02 1.689
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 1.885390e-02 1.725
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 2.059578e-02 1.686
R-HSA-9958790 SLC-mediated transport of inorganic anions 2.085466e-02 1.681
R-HSA-917977 Transferrin endocytosis and recycling 1.743254e-02 1.759
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 1.955809e-02 1.709
R-HSA-9700206 Signaling by ALK in cancer 1.955809e-02 1.709
R-HSA-8939211 ESR-mediated signaling 1.896960e-02 1.722
R-HSA-177504 Retrograde neurotrophin signalling 2.289845e-02 1.640
R-HSA-1170546 Prolactin receptor signaling 2.289845e-02 1.640
R-HSA-9824446 Viral Infection Pathways 2.342663e-02 1.630
R-HSA-389948 Co-inhibition by PD-1 2.413685e-02 1.617
R-HSA-9609646 HCMV Infection 2.452105e-02 1.610
R-HSA-162582 Signal Transduction 2.513665e-02 1.600
R-HSA-170670 Adenylate cyclase inhibitory pathway 2.530189e-02 1.597
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 2.530189e-02 1.597
R-HSA-3270619 IRF3-mediated induction of type I IFN 2.530189e-02 1.597
R-HSA-416482 G alpha (12/13) signalling events 2.577274e-02 1.589
R-HSA-9711097 Cellular response to starvation 2.722944e-02 1.565
R-HSA-977444 GABA B receptor activation 2.731811e-02 1.564
R-HSA-991365 Activation of GABAB receptors 2.731811e-02 1.564
R-HSA-9006931 Signaling by Nuclear Receptors 2.747995e-02 1.561
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 3.039940e-02 1.517
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 3.308781e-02 1.480
R-HSA-437239 Recycling pathway of L1 3.472736e-02 1.459
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 3.039940e-02 1.517
R-HSA-212165 Epigenetic regulation of gene expression 3.454300e-02 1.462
R-HSA-5099900 WNT5A-dependent internalization of FZD4 2.780316e-02 1.556
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 3.317041e-02 1.479
R-HSA-397014 Muscle contraction 3.154501e-02 1.501
R-HSA-1483148 Synthesis of PG 3.039940e-02 1.517
R-HSA-190828 Gap junction trafficking 3.016891e-02 1.520
R-HSA-1500931 Cell-Cell communication 3.092050e-02 1.510
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 3.472736e-02 1.459
R-HSA-1280218 Adaptive Immune System 3.499246e-02 1.456
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 3.586563e-02 1.445
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.632157e-02 1.440
R-HSA-5602636 IKBKB deficiency causes SCID 3.783357e-02 1.422
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 3.783357e-02 1.422
R-HSA-5619087 Defective SLC12A3 causes Gitelman syndrome (GS) 3.783357e-02 1.422
R-HSA-164939 Nef mediated downregulation of CD28 cell surface expression 3.783357e-02 1.422
R-HSA-157858 Gap junction trafficking and regulation 3.795288e-02 1.421
R-HSA-1834941 STING mediated induction of host immune responses 3.873016e-02 1.412
R-HSA-5653656 Vesicle-mediated transport 3.997531e-02 1.398
R-HSA-9678108 SARS-CoV-1 Infection 4.060326e-02 1.391
R-HSA-8878171 Transcriptional regulation by RUNX1 4.108308e-02 1.386
R-HSA-5620916 VxPx cargo-targeting to cilium 4.167875e-02 1.380
R-HSA-74752 Signaling by Insulin receptor 4.367630e-02 1.360
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 4.470882e-02 1.350
R-HSA-392170 ADP signalling through P2Y purinoceptor 12 4.470882e-02 1.350
R-HSA-162594 Early Phase of HIV Life Cycle 4.470882e-02 1.350
R-HSA-432722 Golgi Associated Vesicle Biogenesis 4.484517e-02 1.348
R-HSA-9639288 Amino acids regulate mTORC1 4.484517e-02 1.348
R-HSA-445355 Smooth Muscle Contraction 4.484517e-02 1.348
R-HSA-72649 Translation initiation complex formation 4.665893e-02 1.331
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 4.665893e-02 1.331
R-HSA-201681 TCF dependent signaling in response to WNT 4.768112e-02 1.322
R-HSA-5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) 5.012547e-02 1.300
R-HSA-72702 Ribosomal scanning and start codon recognition 5.039355e-02 1.298
R-HSA-69618 Mitotic Spindle Checkpoint 5.616988e-02 1.250
R-HSA-180786 Extension of Telomeres 5.625918e-02 1.250
R-HSA-982772 Growth hormone receptor signaling 5.426273e-02 1.265
R-HSA-933542 TRAF6 mediated NF-kB activation 5.759380e-02 1.240
R-HSA-977443 GABA receptor activation 5.828356e-02 1.234
R-HSA-3295583 TRP channels 6.446148e-02 1.191
R-HSA-3249367 STAT6-mediated induction of chemokines 6.226109e-02 1.206
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 6.446148e-02 1.191
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 5.426919e-02 1.265
R-HSA-9033241 Peroxisomal protein import 5.625918e-02 1.250
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 5.040243e-02 1.298
R-HSA-8964038 LDL clearance 5.100328e-02 1.292
R-HSA-193648 NRAGE signals death through JNK 5.039355e-02 1.298
R-HSA-422475 Axon guidance 6.332469e-02 1.198
R-HSA-193704 p75 NTR receptor-mediated signalling 5.469597e-02 1.262
R-HSA-195721 Signaling by WNT 5.469520e-02 1.262
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 6.512238e-02 1.186
R-HSA-9692914 SARS-CoV-1-host interactions 6.707937e-02 1.173
R-HSA-9856651 MITF-M-dependent gene expression 6.718902e-02 1.173
R-HSA-388841 Regulation of T cell activation by CD28 family 6.735512e-02 1.172
R-HSA-174414 Processive synthesis on the C-strand of the telomere 6.799354e-02 1.168
R-HSA-69620 Cell Cycle Checkpoints 6.939859e-02 1.159
R-HSA-5693532 DNA Double-Strand Break Repair 7.125773e-02 1.147
R-HSA-171319 Telomere Extension By Telomerase 7.158813e-02 1.145
R-HSA-2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 7.424241e-02 1.129
R-HSA-9759475 Regulation of CDH11 Expression and Function 7.524311e-02 1.124
R-HSA-5663205 Infectious disease 7.555117e-02 1.122
R-HSA-9730414 MITF-M-regulated melanocyte development 8.195986e-02 1.086
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 9.774991e-02 1.010
R-HSA-182218 Nef Mediated CD8 Down-regulation 9.774991e-02 1.010
R-HSA-9842640 Signaling by LTK in cancer 1.092799e-01 0.961
R-HSA-9700645 ALK mutants bind TKIs 1.429975e-01 0.845
R-HSA-164843 2-LTR circle formation 1.539520e-01 0.813
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.963940e-01 0.707
R-HSA-176412 Phosphorylation of the APC/C 2.268288e-01 0.644
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 2.268288e-01 0.644
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 2.268288e-01 0.644
R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis 2.268288e-01 0.644
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 2.367166e-01 0.626
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 2.464786e-01 0.608
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1.807721e-01 0.743
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 1.853710e-01 0.732
R-HSA-141424 Amplification of signal from the kinetochores 1.218210e-01 0.914
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 1.218210e-01 0.914
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 1.946175e-01 0.711
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1.992629e-01 0.701
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 1.390455e-01 0.857
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1.419933e-01 0.848
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 1.539890e-01 0.813
R-HSA-72689 Formation of a pool of free 40S subunits 1.570368e-01 0.804
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 2.320917e-01 0.634
R-HSA-380259 Loss of Nlp from mitotic centrosomes 2.320917e-01 0.634
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 2.415412e-01 0.617
R-HSA-8854518 AURKA Activation by TPX2 2.462728e-01 0.609
R-HSA-192823 Viral mRNA Translation 1.820563e-01 0.740
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 1.982040e-01 0.703
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 2.014748e-01 0.696
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 1.316462e-01 0.881
R-HSA-927802 Nonsense-Mediated Decay (NMD) 2.146819e-01 0.668
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 1.647672e-01 0.783
R-HSA-156902 Peptide chain elongation 1.303315e-01 0.885
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 2.146819e-01 0.668
R-HSA-174430 Telomere C-strand synthesis initiation 2.168135e-01 0.664
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 2.132741e-01 0.671
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 1.859864e-01 0.731
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 2.267614e-01 0.644
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 1.580704e-01 0.801
R-HSA-1169091 Activation of NF-kappaB in B cells 1.761911e-01 0.754
R-HSA-8857538 PTK6 promotes HIF1A stabilization 1.092799e-01 0.961
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 2.464786e-01 0.608
R-HSA-3928664 Ephrin signaling 2.561163e-01 0.592
R-HSA-2467813 Separation of Sister Chromatids 2.079672e-01 0.682
R-HSA-5693606 DNA Double Strand Break Response 2.510078e-01 0.600
R-HSA-167590 Nef Mediated CD4 Down-regulation 1.206633e-01 0.918
R-HSA-5696394 DNA Damage Recognition in GG-NER 9.435125e-02 1.025
R-HSA-72764 Eukaryotic Translation Termination 1.570368e-01 0.804
R-HSA-72737 Cap-dependent Translation Initiation 2.348201e-01 0.629
R-HSA-9758274 Regulation of NF-kappa B signaling 2.268288e-01 0.644
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 2.464786e-01 0.608
R-HSA-72613 Eukaryotic Translation Initiation 2.348201e-01 0.629
R-HSA-389542 NADPH regeneration 1.092799e-01 0.961
R-HSA-176974 Unwinding of DNA 1.429975e-01 0.845
R-HSA-192814 vRNA Synthesis 1.647672e-01 0.783
R-HSA-209560 NF-kB is activated and signals survival 1.754447e-01 0.756
R-HSA-432720 Lysosome Vesicle Biogenesis 1.064121e-01 0.973
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 2.561163e-01 0.592
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 2.561163e-01 0.592
R-HSA-5655291 Signaling by FGFR4 in disease 2.066691e-01 0.685
R-HSA-5655302 Signaling by FGFR1 in disease 1.316462e-01 0.881
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 2.367166e-01 0.626
R-HSA-156842 Eukaryotic Translation Elongation 1.449620e-01 0.839
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 2.561163e-01 0.592
R-HSA-429914 Deadenylation-dependent mRNA decay 2.132741e-01 0.671
R-HSA-170968 Frs2-mediated activation 1.963940e-01 0.707
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 2.273757e-01 0.643
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 1.429975e-01 0.845
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 2.168135e-01 0.664
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 2.561163e-01 0.592
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 2.014748e-01 0.696
R-HSA-68877 Mitotic Prometaphase 1.395881e-01 0.855
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 2.518489e-01 0.599
R-HSA-5260271 Diseases of Immune System 1.230859e-01 0.910
R-HSA-5602358 Diseases associated with the TLR signaling cascade 1.230859e-01 0.910
R-HSA-2408557 Selenocysteine synthesis 1.757013e-01 0.755
R-HSA-373760 L1CAM interactions 8.812744e-02 1.055
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 9.042520e-02 1.044
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 1.852570e-01 0.732
R-HSA-169893 Prolonged ERK activation events 2.268288e-01 0.644
R-HSA-937039 IRAK1 recruits IKK complex 1.859864e-01 0.731
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 1.859864e-01 0.731
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 2.066691e-01 0.685
R-HSA-69166 Removal of the Flap Intermediate 2.066691e-01 0.685
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 1.580704e-01 0.801
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 1.852570e-01 0.732
R-HSA-193639 p75NTR signals via NF-kB 2.168135e-01 0.664
R-HSA-69239 Synthesis of DNA 1.982040e-01 0.703
R-HSA-162592 Integration of provirus 1.754447e-01 0.756
R-HSA-168273 Influenza Viral RNA Transcription and Replication 1.845260e-01 0.734
R-HSA-73933 Resolution of Abasic Sites (AP sites) 1.273488e-01 0.895
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 8.607137e-02 1.065
R-HSA-9764302 Regulation of CDH19 Expression and Function 9.774991e-02 1.010
R-HSA-448706 Interleukin-1 processing 1.429975e-01 0.845
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 1.647672e-01 0.783
R-HSA-427601 Inorganic anion exchange by SLC26 transporters 1.647672e-01 0.783
R-HSA-1483248 Synthesis of PIPs at the ER membrane 1.647672e-01 0.783
R-HSA-69190 DNA strand elongation 8.654940e-02 1.063
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 2.047584e-01 0.689
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.550102e-01 0.810
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 9.774991e-02 1.010
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 2.268288e-01 0.644
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 2.464786e-01 0.608
R-HSA-9753281 Paracetamol ADME 1.946175e-01 0.711
R-HSA-392518 Signal amplification 9.832566e-02 1.007
R-HSA-9635465 Suppression of apoptosis 1.647672e-01 0.783
R-HSA-69183 Processive synthesis on the lagging strand 2.168135e-01 0.664
R-HSA-8854214 TBC/RABGAPs 1.403384e-01 0.853
R-HSA-8964043 Plasma lipoprotein clearance 1.188591e-01 0.925
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 2.557455e-01 0.592
R-HSA-2028269 Signaling by Hippo 2.464786e-01 0.608
R-HSA-1852241 Organelle biogenesis and maintenance 1.505981e-01 0.822
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 2.268288e-01 0.644
R-HSA-373755 Semaphorin interactions 2.320917e-01 0.634
R-HSA-112040 G-protein mediated events 2.510078e-01 0.600
R-HSA-9705683 SARS-CoV-2-host interactions 1.024460e-01 0.990
R-HSA-9758890 Transport of RCbl within the body 1.647672e-01 0.783
R-HSA-209543 p75NTR recruits signalling complexes 1.859864e-01 0.731
R-HSA-9683610 Maturation of nucleoprotein 1.963940e-01 0.707
R-HSA-8856688 Golgi-to-ER retrograde transport 1.248554e-01 0.904
R-HSA-5693538 Homology Directed Repair 9.191310e-02 1.037
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 1.805309e-01 0.743
R-HSA-9675108 Nervous system development 9.076288e-02 1.042
R-HSA-111885 Opioid Signalling 1.852570e-01 0.732
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 1.023465e-01 0.990
R-HSA-9634597 GPER1 signaling 1.625675e-01 0.789
R-HSA-983712 Ion channel transport 1.319443e-01 0.880
R-HSA-392499 Metabolism of proteins 2.018274e-01 0.695
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 1.491503e-01 0.826
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 1.491503e-01 0.826
R-HSA-1643685 Disease 1.892225e-01 0.723
R-HSA-418597 G alpha (z) signalling events 1.946175e-01 0.711
R-HSA-168256 Immune System 1.144809e-01 0.941
R-HSA-8964539 Glutamate and glutamine metabolism 9.435125e-02 1.025
R-HSA-168255 Influenza Infection 1.137089e-01 0.944
R-HSA-73887 Death Receptor Signaling 1.819774e-01 0.740
R-HSA-917937 Iron uptake and transport 9.254466e-02 1.034
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 8.757663e-02 1.058
R-HSA-1483166 Synthesis of PA 2.039215e-01 0.691
R-HSA-1989781 PPARA activates gene expression 1.845260e-01 0.734
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 2.320917e-01 0.634
R-HSA-9694516 SARS-CoV-2 Infection 1.993166e-01 0.700
R-HSA-9759194 Nuclear events mediated by NFE2L2 9.773486e-02 1.010
R-HSA-2980736 Peptide hormone metabolism 9.001062e-02 1.046
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 2.368138e-01 0.626
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 1.896582e-01 0.722
R-HSA-9679506 SARS-CoV Infections 2.094541e-01 0.679
R-HSA-9755511 KEAP1-NFE2L2 pathway 1.744041e-01 0.758
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 2.561163e-01 0.592
R-HSA-1592230 Mitochondrial biogenesis 2.382097e-01 0.623
R-HSA-1222556 ROS and RNS production in phagocytes 9.004617e-02 1.046
R-HSA-157118 Signaling by NOTCH 1.205941e-01 0.919
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 2.652251e-01 0.576
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 2.656313e-01 0.576
R-HSA-5654710 PI-3K cascade:FGFR3 2.656313e-01 0.576
R-HSA-937041 IKK complex recruitment mediated by RIP1 2.656313e-01 0.576
R-HSA-9694631 Maturation of nucleoprotein 2.656313e-01 0.576
R-HSA-844456 The NLRP3 inflammasome 2.656313e-01 0.576
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 2.699656e-01 0.569
R-HSA-453276 Regulation of mitotic cell cycle 2.699656e-01 0.569
R-HSA-5620920 Cargo trafficking to the periciliary membrane 2.699656e-01 0.569
R-HSA-6798695 Neutrophil degranulation 2.743133e-01 0.562
R-HSA-5654720 PI-3K cascade:FGFR4 2.750252e-01 0.561
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 2.750252e-01 0.561
R-HSA-77111 Synthesis of Ketone Bodies 2.750252e-01 0.561
R-HSA-69481 G2/M Checkpoints 2.759728e-01 0.559
R-HSA-8868773 rRNA processing in the nucleus and cytosol 2.768280e-01 0.558
R-HSA-187037 Signaling by NTRK1 (TRKA) 2.794399e-01 0.554
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 2.794438e-01 0.554
R-HSA-69052 Switching of origins to a post-replicative state 2.794438e-01 0.554
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 2.794438e-01 0.554
R-HSA-112315 Transmission across Chemical Synapses 2.805506e-01 0.552
R-HSA-5617833 Cilium Assembly 2.825095e-01 0.549
R-HSA-1226099 Signaling by FGFR in disease 2.841800e-01 0.546
R-HSA-69473 G2/M DNA damage checkpoint 2.841800e-01 0.546
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 2.842995e-01 0.546
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin 2.842995e-01 0.546
R-HSA-69186 Lagging Strand Synthesis 2.842995e-01 0.546
R-HSA-380287 Centrosome maturation 2.889135e-01 0.539
R-HSA-71403 Citric acid cycle (TCA cycle) 2.889135e-01 0.539
R-HSA-5654706 FRS-mediated FGFR3 signaling 2.934558e-01 0.532
R-HSA-8876384 Listeria monocytogenes entry into host cells 2.934558e-01 0.532
R-HSA-977347 Serine metabolism 2.934558e-01 0.532
R-HSA-174403 Glutathione synthesis and recycling 2.934558e-01 0.532
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 2.983690e-01 0.525
R-HSA-5654689 PI-3K cascade:FGFR1 3.024954e-01 0.519
R-HSA-5654712 FRS-mediated FGFR4 signaling 3.024954e-01 0.519
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 3.024954e-01 0.519
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 3.024954e-01 0.519
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 3.024954e-01 0.519
R-HSA-4086400 PCP/CE pathway 3.030898e-01 0.518
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 3.078051e-01 0.512
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 3.114200e-01 0.507
R-HSA-74182 Ketone body metabolism 3.114200e-01 0.507
R-HSA-9833482 PKR-mediated signaling 3.125142e-01 0.505
R-HSA-163685 Integration of energy metabolism 3.142867e-01 0.503
R-HSA-5693607 Processing of DNA double-strand break ends 3.172166e-01 0.499
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 3.202309e-01 0.495
R-HSA-429947 Deadenylation of mRNA 3.202309e-01 0.495
R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus 3.202309e-01 0.495
R-HSA-9865881 Complex III assembly 3.202309e-01 0.495
R-HSA-5621575 CD209 (DC-SIGN) signaling 3.202309e-01 0.495
R-HSA-9948299 Ribosome-associated quality control 3.212778e-01 0.493
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 3.289296e-01 0.483
R-HSA-1296041 Activation of G protein gated Potassium channels 3.289296e-01 0.483
R-HSA-1296059 G protein gated Potassium channels 3.289296e-01 0.483
R-HSA-5654695 PI-3K cascade:FGFR2 3.289296e-01 0.483
R-HSA-5654693 FRS-mediated FGFR1 signaling 3.289296e-01 0.483
R-HSA-174411 Polymerase switching on the C-strand of the telomere 3.289296e-01 0.483
R-HSA-400685 Sema4D in semaphorin signaling 3.289296e-01 0.483
R-HSA-1482801 Acyl chain remodelling of PS 3.289296e-01 0.483
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 3.312773e-01 0.480
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 3.312773e-01 0.480
R-HSA-6802957 Oncogenic MAPK signaling 3.359468e-01 0.474
R-HSA-9703465 Signaling by FLT3 fusion proteins 3.375175e-01 0.472
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 3.375175e-01 0.472
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 3.375175e-01 0.472
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 3.375175e-01 0.472
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 3.387573e-01 0.470
R-HSA-8856828 Clathrin-mediated endocytosis 3.422513e-01 0.466
R-HSA-381038 XBP1(S) activates chaperone genes 3.452567e-01 0.462
R-HSA-445095 Interaction between L1 and Ankyrins 3.459961e-01 0.461
R-HSA-73863 RNA Polymerase I Transcription Termination 3.459961e-01 0.461
R-HSA-5655332 Signaling by FGFR3 in disease 3.459961e-01 0.461
R-HSA-3928663 EPHA-mediated growth cone collapse 3.459961e-01 0.461
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 3.459961e-01 0.461
R-HSA-9006115 Signaling by NTRK2 (TRKB) 3.459961e-01 0.461
R-HSA-5654700 FRS-mediated FGFR2 signaling 3.543666e-01 0.451
R-HSA-5654732 Negative regulation of FGFR3 signaling 3.543666e-01 0.451
R-HSA-622312 Inflammasomes 3.543666e-01 0.451
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 3.545242e-01 0.450
R-HSA-69242 S Phase 3.596960e-01 0.444
R-HSA-166520 Signaling by NTRKs 3.596960e-01 0.444
R-HSA-68882 Mitotic Anaphase 3.603744e-01 0.443
R-HSA-5654708 Downstream signaling of activated FGFR3 3.626306e-01 0.441
R-HSA-5654733 Negative regulation of FGFR4 signaling 3.626306e-01 0.441
R-HSA-180024 DARPP-32 events 3.626306e-01 0.441
R-HSA-2555396 Mitotic Metaphase and Anaphase 3.632752e-01 0.440
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 3.637456e-01 0.439
R-HSA-9679191 Potential therapeutics for SARS 3.666574e-01 0.436
R-HSA-68962 Activation of the pre-replicative complex 3.707892e-01 0.431
R-HSA-5654716 Downstream signaling of activated FGFR4 3.707892e-01 0.431
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 3.707892e-01 0.431
R-HSA-381070 IRE1alpha activates chaperones 3.729171e-01 0.428
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 3.736062e-01 0.428
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 3.774831e-01 0.423
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 3.788439e-01 0.422
R-HSA-399719 Trafficking of AMPA receptors 3.788439e-01 0.422
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 3.805407e-01 0.420
R-HSA-1296065 Inwardly rectifying K+ channels 3.867960e-01 0.413
R-HSA-9675126 Diseases of mitotic cell cycle 3.867960e-01 0.413
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 3.867960e-01 0.413
R-HSA-111465 Apoptotic cleavage of cellular proteins 3.867960e-01 0.413
R-HSA-162587 HIV Life Cycle 3.909113e-01 0.408
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 3.910974e-01 0.408
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 3.910974e-01 0.408
R-HSA-162906 HIV Infection 3.922367e-01 0.406
R-HSA-354192 Integrin signaling 3.946468e-01 0.404
R-HSA-1839124 FGFR1 mutant receptor activation 3.946468e-01 0.404
R-HSA-176187 Activation of ATR in response to replication stress 3.946468e-01 0.404
R-HSA-5654726 Negative regulation of FGFR1 signaling 3.946468e-01 0.404
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 3.946468e-01 0.404
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 3.946468e-01 0.404
R-HSA-6807878 COPI-mediated anterograde transport 4.000999e-01 0.398
R-HSA-5607764 CLEC7A (Dectin-1) signaling 4.000999e-01 0.398
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 4.023976e-01 0.395
R-HSA-199220 Vitamin B5 (pantothenate) metabolism 4.023976e-01 0.395
R-HSA-189483 Heme degradation 4.023976e-01 0.395
R-HSA-72312 rRNA processing 4.066556e-01 0.391
R-HSA-975871 MyD88 cascade initiated on plasma membrane 4.090401e-01 0.388
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 4.090401e-01 0.388
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 4.090401e-01 0.388
R-HSA-5696400 Dual Incision in GG-NER 4.100496e-01 0.387
R-HSA-5654727 Negative regulation of FGFR2 signaling 4.100496e-01 0.387
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 4.100496e-01 0.387
R-HSA-168638 NOD1/2 Signaling Pathway 4.100496e-01 0.387
R-HSA-2408522 Selenoamino acid metabolism 4.149328e-01 0.382
R-HSA-5654696 Downstream signaling of activated FGFR2 4.176040e-01 0.379
R-HSA-5654687 Downstream signaling of activated FGFR1 4.176040e-01 0.379
R-HSA-187687 Signalling to ERKs 4.176040e-01 0.379
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 4.176040e-01 0.379
R-HSA-983169 Class I MHC mediated antigen processing & presentation 4.183419e-01 0.378
R-HSA-9020702 Interleukin-1 signaling 4.223281e-01 0.374
R-HSA-9009391 Extra-nuclear estrogen signaling 4.223281e-01 0.374
R-HSA-9682385 FLT3 signaling in disease 4.250622e-01 0.372
R-HSA-9845576 Glycosphingolipid transport 4.250622e-01 0.372
R-HSA-8853659 RET signaling 4.250622e-01 0.372
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 4.324254e-01 0.364
R-HSA-549127 SLC-mediated transport of organic cations 4.324254e-01 0.364
R-HSA-9860931 Response of endothelial cells to shear stress 4.354618e-01 0.361
R-HSA-418555 G alpha (s) signalling events 4.420095e-01 0.355
R-HSA-5621481 C-type lectin receptors (CLRs) 4.420095e-01 0.355
R-HSA-5696398 Nucleotide Excision Repair 4.441284e-01 0.352
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 4.441284e-01 0.352
R-HSA-201556 Signaling by ALK 4.468713e-01 0.350
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 4.520412e-01 0.345
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 4.539565e-01 0.343
R-HSA-5696395 Formation of Incision Complex in GG-NER 4.539565e-01 0.343
R-HSA-9854311 Maturation of TCA enzymes and regulation of TCA cycle 4.539565e-01 0.343
R-HSA-379726 Mitochondrial tRNA aminoacylation 4.539565e-01 0.343
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 4.569892e-01 0.340
R-HSA-2672351 Stimuli-sensing channels 4.569892e-01 0.340
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 4.609513e-01 0.336
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 4.609513e-01 0.336
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 4.609513e-01 0.336
R-HSA-8853884 Transcriptional Regulation by VENTX 4.609513e-01 0.336
R-HSA-5218920 VEGFR2 mediated vascular permeability 4.609513e-01 0.336
R-HSA-3214841 PKMTs methylate histone lysines 4.609513e-01 0.336
R-HSA-975155 MyD88 dependent cascade initiated on endosome 4.612382e-01 0.336
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 4.654678e-01 0.332
R-HSA-166166 MyD88-independent TLR4 cascade 4.654678e-01 0.332
R-HSA-167161 HIV Transcription Initiation 4.678569e-01 0.330
R-HSA-75953 RNA Polymerase II Transcription Initiation 4.678569e-01 0.330
R-HSA-5674135 MAP2K and MAPK activation 4.678569e-01 0.330
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 4.678569e-01 0.330
R-HSA-9656223 Signaling by RAF1 mutants 4.678569e-01 0.330
R-HSA-6811438 Intra-Golgi traffic 4.678569e-01 0.330
R-HSA-9683701 Translation of Structural Proteins 4.678569e-01 0.330
R-HSA-1266738 Developmental Biology 4.722564e-01 0.326
R-HSA-73762 RNA Polymerase I Transcription Initiation 4.746745e-01 0.324
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 4.780387e-01 0.321
R-HSA-73776 RNA Polymerase II Promoter Escape 4.814052e-01 0.317
R-HSA-5654743 Signaling by FGFR4 4.814052e-01 0.317
R-HSA-9637690 Response of Mtb to phagocytosis 4.814052e-01 0.317
R-HSA-9855142 Cellular responses to mechanical stimuli 4.821890e-01 0.317
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 4.821890e-01 0.317
R-HSA-3928662 EPHB-mediated forward signaling 4.880501e-01 0.312
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 4.880501e-01 0.312
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 4.880501e-01 0.312
R-HSA-375280 Amine ligand-binding receptors 4.880501e-01 0.312
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 4.904287e-01 0.309
R-HSA-2029485 Role of phospholipids in phagocytosis 4.945178e-01 0.306
R-HSA-4420097 VEGFA-VEGFR2 Pathway 4.945178e-01 0.306
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 4.946102e-01 0.306
R-HSA-6783310 Fanconi Anemia Pathway 4.946102e-01 0.306
R-HSA-76009 Platelet Aggregation (Plug Formation) 4.946102e-01 0.306
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 4.946102e-01 0.306
R-HSA-5654741 Signaling by FGFR3 4.946102e-01 0.306
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 5.010867e-01 0.300
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 5.010867e-01 0.300
R-HSA-9649948 Signaling downstream of RAS mutants 5.010867e-01 0.300
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 5.010867e-01 0.300
R-HSA-6802949 Signaling by RAS mutants 5.010867e-01 0.300
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 5.010867e-01 0.300
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 5.010867e-01 0.300
R-HSA-5357905 Regulation of TNFR1 signaling 5.010867e-01 0.300
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 5.010867e-01 0.300
R-HSA-75153 Apoptotic execution phase 5.010867e-01 0.300
R-HSA-9007101 Rab regulation of trafficking 5.026337e-01 0.299
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 5.074805e-01 0.295
R-HSA-9711123 Cellular response to chemical stress 5.076211e-01 0.294
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 5.106655e-01 0.292
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 5.106655e-01 0.292
R-HSA-72163 mRNA Splicing - Major Pathway 5.168446e-01 0.287
R-HSA-9766229 Degradation of CDH1 5.200246e-01 0.284
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 5.225537e-01 0.282
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 5.225537e-01 0.282
R-HSA-5655253 Signaling by FGFR2 in disease 5.261769e-01 0.279
R-HSA-109704 PI3K Cascade 5.261769e-01 0.279
R-HSA-9748787 Azathioprine ADME 5.261769e-01 0.279
R-HSA-382551 Transport of small molecules 5.268420e-01 0.278
R-HSA-2514856 The phototransduction cascade 5.322508e-01 0.274
R-HSA-194138 Signaling by VEGF 5.381024e-01 0.269
R-HSA-68949 Orc1 removal from chromatin 5.382471e-01 0.269
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 5.382471e-01 0.269
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 5.382471e-01 0.269
R-HSA-9658195 Leishmania infection 5.422375e-01 0.266
R-HSA-9824443 Parasitic Infection Pathways 5.422375e-01 0.266
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 5.441669e-01 0.264
R-HSA-8956320 Nucleotide biosynthesis 5.441669e-01 0.264
R-HSA-376176 Signaling by ROBO receptors 5.446516e-01 0.264
R-HSA-1483206 Glycerophospholipid biosynthesis 5.446516e-01 0.264
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 5.448496e-01 0.264
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 5.500112e-01 0.260
R-HSA-72172 mRNA Splicing 5.507049e-01 0.259
R-HSA-5654736 Signaling by FGFR1 5.614770e-01 0.251
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 5.614770e-01 0.251
R-HSA-75893 TNF signaling 5.614770e-01 0.251
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 5.614770e-01 0.251
R-HSA-9764561 Regulation of CDH1 Function 5.671004e-01 0.246
R-HSA-112399 IRS-mediated signalling 5.671004e-01 0.246
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 5.671004e-01 0.246
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 5.709308e-01 0.243
R-HSA-9772572 Early SARS-CoV-2 Infection Events 5.726521e-01 0.242
R-HSA-388396 GPCR downstream signalling 5.730031e-01 0.242
R-HSA-1483257 Phospholipid metabolism 5.780924e-01 0.238
R-HSA-8943724 Regulation of PTEN gene transcription 5.835437e-01 0.234
R-HSA-156590 Glutathione conjugation 5.835437e-01 0.234
R-HSA-1660661 Sphingolipid de novo biosynthesis 5.835437e-01 0.234
R-HSA-379724 tRNA Aminoacylation 5.835437e-01 0.234
R-HSA-3858494 Beta-catenin independent WNT signaling 5.861967e-01 0.232
R-HSA-597592 Post-translational protein modification 5.872936e-01 0.231
R-HSA-2428928 IRS-related events triggered by IGF1R 5.888854e-01 0.230
R-HSA-450294 MAP kinase activation 5.888854e-01 0.230
R-HSA-109582 Hemostasis 5.889662e-01 0.230
R-HSA-9748784 Drug ADME 5.917245e-01 0.228
R-HSA-449147 Signaling by Interleukins 5.922132e-01 0.228
R-HSA-381119 Unfolded Protein Response (UPR) 5.967587e-01 0.224
R-HSA-6799198 Complex I biogenesis 5.993652e-01 0.222
R-HSA-6790901 rRNA modification in the nucleus and cytosol 5.993652e-01 0.222
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 5.993652e-01 0.222
R-HSA-8848021 Signaling by PTK6 5.993652e-01 0.222
R-HSA-112316 Neuronal System 6.021207e-01 0.220
R-HSA-2428924 IGF1R signaling cascade 6.045050e-01 0.219
R-HSA-74751 Insulin receptor signalling cascade 6.045050e-01 0.219
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 6.095792e-01 0.215
R-HSA-6782315 tRNA modification in the nucleus and cytosol 6.145885e-01 0.211
R-HSA-196807 Nicotinate metabolism 6.195339e-01 0.208
R-HSA-167172 Transcription of the HIV genome 6.244162e-01 0.205
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 6.244162e-01 0.205
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 6.249175e-01 0.204
R-HSA-199977 ER to Golgi Anterograde Transport 6.272322e-01 0.203
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 6.305062e-01 0.200
R-HSA-75105 Fatty acyl-CoA biosynthesis 6.339944e-01 0.198
R-HSA-448424 Interleukin-17 signaling 6.339944e-01 0.198
R-HSA-8978934 Metabolism of cofactors 6.386919e-01 0.195
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 6.386919e-01 0.195
R-HSA-189445 Metabolism of porphyrins 6.386919e-01 0.195
R-HSA-446652 Interleukin-1 family signaling 6.433791e-01 0.192
R-HSA-674695 RNA Polymerase II Pre-transcription Events 6.524276e-01 0.185
R-HSA-3000171 Non-integrin membrane-ECM interactions 6.568897e-01 0.183
R-HSA-1169408 ISG15 antiviral mechanism 6.568897e-01 0.183
R-HSA-8852135 Protein ubiquitination 6.568897e-01 0.183
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 6.620246e-01 0.179
R-HSA-9694635 Translation of Structural Proteins 6.656435e-01 0.177
R-HSA-9659379 Sensory processing of sound 6.741751e-01 0.171
R-HSA-5654738 Signaling by FGFR2 6.783593e-01 0.169
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 6.783593e-01 0.169
R-HSA-5619102 SLC transporter disorders 6.885213e-01 0.162
R-HSA-72766 Translation 6.887130e-01 0.162
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 6.905937e-01 0.161
R-HSA-9707564 Cytoprotection by HMOX1 6.905937e-01 0.161
R-HSA-372790 Signaling by GPCR 6.963576e-01 0.157
R-HSA-6794362 Protein-protein interactions at synapses 6.984915e-01 0.156
R-HSA-5687128 MAPK6/MAPK4 signaling 6.984915e-01 0.156
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 7.061887e-01 0.151
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 7.061887e-01 0.151
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 7.079360e-01 0.150
R-HSA-9664433 Leishmania parasite growth and survival 7.079360e-01 0.150
R-HSA-438064 Post NMDA receptor activation events 7.099636e-01 0.149
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 7.136903e-01 0.146
R-HSA-1236974 ER-Phagosome pathway 7.173693e-01 0.144
R-HSA-112310 Neurotransmitter release cycle 7.210013e-01 0.142
R-HSA-202424 Downstream TCR signaling 7.210013e-01 0.142
R-HSA-196854 Metabolism of vitamins and cofactors 7.292688e-01 0.137
R-HSA-76002 Platelet activation, signaling and aggregation 7.304141e-01 0.136
R-HSA-9772573 Late SARS-CoV-2 Infection Events 7.316208e-01 0.136
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 7.384761e-01 0.132
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 7.407982e-01 0.130
R-HSA-69275 G2/M Transition 7.413207e-01 0.130
R-HSA-453274 Mitotic G2-G2/M phases 7.461584e-01 0.127
R-HSA-5389840 Mitochondrial translation elongation 7.484335e-01 0.126
R-HSA-1296071 Potassium Channels 7.484335e-01 0.126
R-HSA-170834 Signaling by TGF-beta Receptor Complex 7.516681e-01 0.124
R-HSA-168898 Toll-like Receptor Cascades 7.532702e-01 0.123
R-HSA-190236 Signaling by FGFR 7.548613e-01 0.122
R-HSA-5368286 Mitochondrial translation initiation 7.548613e-01 0.122
R-HSA-422356 Regulation of insulin secretion 7.548613e-01 0.122
R-HSA-1280215 Cytokine Signaling in Immune system 7.553144e-01 0.122
R-HSA-168249 Innate Immune System 7.575973e-01 0.121
R-HSA-5610787 Hedgehog 'off' state 7.611256e-01 0.119
R-HSA-382556 ABC-family proteins mediated transport 7.611256e-01 0.119
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 7.672306e-01 0.115
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 7.672306e-01 0.115
R-HSA-1483255 PI Metabolism 7.672306e-01 0.115
R-HSA-9937383 Mitochondrial ribosome-associated quality control 7.702246e-01 0.113
R-HSA-8953854 Metabolism of RNA 7.756087e-01 0.110
R-HSA-9833110 RSV-host interactions 7.760982e-01 0.110
R-HSA-948021 Transport to the Golgi and subsequent modification 7.779000e-01 0.109
R-HSA-425407 SLC-mediated transmembrane transport 7.872581e-01 0.104
R-HSA-1236975 Antigen processing-Cross presentation 7.874007e-01 0.104
R-HSA-5419276 Mitochondrial translation termination 7.901365e-01 0.102
R-HSA-202403 TCR signaling 7.928372e-01 0.101
R-HSA-418594 G alpha (i) signalling events 8.023126e-01 0.096
R-HSA-8978868 Fatty acid metabolism 8.023126e-01 0.096
R-HSA-8951664 Neddylation 8.172237e-01 0.088
R-HSA-2219528 PI3K/AKT Signaling in Cancer 8.180129e-01 0.087
R-HSA-3371556 Cellular response to heat stress 8.249539e-01 0.084
R-HSA-9635486 Infection with Mycobacterium tuberculosis 8.249539e-01 0.084
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 8.294343e-01 0.081
R-HSA-6809371 Formation of the cornified envelope 8.316315e-01 0.080
R-HSA-162909 Host Interactions of HIV factors 8.316315e-01 0.080
R-HSA-71291 Metabolism of amino acids and derivatives 8.330678e-01 0.079
R-HSA-69206 G1/S Transition 8.359417e-01 0.078
R-HSA-114608 Platelet degranulation 8.401421e-01 0.076
R-HSA-1428517 Aerobic respiration and respiratory electron transport 8.447230e-01 0.073
R-HSA-199418 Negative regulation of the PI3K/AKT network 8.462429e-01 0.073
R-HSA-5683057 MAPK family signaling cascades 8.525676e-01 0.069
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 8.540183e-01 0.069
R-HSA-5619115 Disorders of transmembrane transporters 8.590174e-01 0.066
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 8.631894e-01 0.064
R-HSA-5368287 Mitochondrial translation 8.649537e-01 0.063
R-HSA-5358351 Signaling by Hedgehog 8.649537e-01 0.063
R-HSA-6807070 PTEN Regulation 8.666952e-01 0.062
R-HSA-9664417 Leishmania phagocytosis 8.684145e-01 0.061
R-HSA-9664422 FCGR3A-mediated phagocytosis 8.684145e-01 0.061
R-HSA-9664407 Parasite infection 8.684145e-01 0.061
R-HSA-1632852 Macroautophagy 8.701116e-01 0.060
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 8.701116e-01 0.060
R-HSA-162599 Late Phase of HIV Life Cycle 8.734409e-01 0.059
R-HSA-2871837 FCERI mediated NF-kB activation 8.766852e-01 0.057
R-HSA-453279 Mitotic G1 phase and G1/S transition 8.798468e-01 0.056
R-HSA-2187338 Visual phototransduction 8.813972e-01 0.055
R-HSA-416476 G alpha (q) signalling events 8.814360e-01 0.055
R-HSA-2142753 Arachidonate metabolism 8.888555e-01 0.051
R-HSA-913531 Interferon Signaling 8.937280e-01 0.049
R-HSA-9612973 Autophagy 8.944846e-01 0.048
R-HSA-9006936 Signaling by TGFB family members 8.998299e-01 0.046
R-HSA-5633007 Regulation of TP53 Activity 8.998299e-01 0.046
R-HSA-109581 Apoptosis 9.024006e-01 0.045
R-HSA-5673001 RAF/MAP kinase cascade 9.084956e-01 0.042
R-HSA-72306 tRNA processing 9.131799e-01 0.039
R-HSA-1257604 PIP3 activates AKT signaling 9.140734e-01 0.039
R-HSA-5684996 MAPK1/MAPK3 signaling 9.149716e-01 0.039
R-HSA-611105 Respiratory electron transport 9.217623e-01 0.035
R-HSA-8957322 Metabolism of steroids 9.368241e-01 0.028
R-HSA-428157 Sphingolipid metabolism 9.420132e-01 0.026
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 9.435053e-01 0.025
R-HSA-5357801 Programmed Cell Death 9.456720e-01 0.024
R-HSA-6805567 Keratinization 9.463757e-01 0.024
R-HSA-9006925 Intracellular signaling by second messengers 9.479478e-01 0.023
R-HSA-556833 Metabolism of lipids 9.567266e-01 0.019
R-HSA-15869 Metabolism of nucleotides 9.637478e-01 0.016
R-HSA-156580 Phase II - Conjugation of compounds 9.651410e-01 0.015
R-HSA-9824439 Bacterial Infection Pathways 9.695666e-01 0.013
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.708875e-01 0.013
R-HSA-446203 Asparagine N-linked glycosylation 9.787067e-01 0.009
R-HSA-500792 GPCR ligand binding 9.857544e-01 0.006
R-HSA-3700989 Transcriptional Regulation by TP53 9.869179e-01 0.006
R-HSA-1474244 Extracellular matrix organization 9.895580e-01 0.005
R-HSA-212436 Generic Transcription Pathway 9.928447e-01 0.003
R-HSA-74160 Gene expression (Transcription) 9.936545e-01 0.003
R-HSA-73857 RNA Polymerase II Transcription 9.947260e-01 0.002
R-HSA-5668914 Diseases of metabolism 9.970928e-01 0.001
R-HSA-211859 Biological oxidations 9.991862e-01 0.000
R-HSA-1430728 Metabolism 9.999342e-01 0.000
R-HSA-9709957 Sensory Perception 9.999991e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
PRKD2PRKD2 0.863 0.235 -3 0.756
COTCOT 0.862 0.077 2 0.897
PRKD1PRKD1 0.861 0.215 -3 0.757
CDC7CDC7 0.858 0.068 1 0.866
CAMK1BCAMK1B 0.856 0.155 -3 0.796
RSK2RSK2 0.855 0.129 -3 0.720
RAF1RAF1 0.853 0.057 1 0.822
PIM3PIM3 0.852 0.068 -3 0.759
MOSMOS 0.852 0.067 1 0.868
SKMLCKSKMLCK 0.852 0.191 -2 0.880
WNK1WNK1 0.851 0.190 -2 0.880
MAPKAPK3MAPKAPK3 0.851 0.127 -3 0.748
NDR2NDR2 0.849 0.056 -3 0.781
DSTYKDSTYK 0.849 0.017 2 0.914
RSK3RSK3 0.849 0.097 -3 0.701
PRPKPRPK 0.849 -0.093 -1 0.852
PRKD3PRKD3 0.849 0.182 -3 0.715
NDR1NDR1 0.848 0.098 -3 0.790
AURCAURC 0.848 0.204 -2 0.744
PKN2PKN2 0.848 0.157 -3 0.803
PIM1PIM1 0.848 0.124 -3 0.735
CLK3CLK3 0.848 0.118 1 0.756
MST4MST4 0.848 0.151 2 0.866
MAPKAPK2MAPKAPK2 0.847 0.096 -3 0.701
P90RSKP90RSK 0.847 0.073 -3 0.702
PKN3PKN3 0.847 0.071 -3 0.754
CAMK2DCAMK2D 0.847 0.100 -3 0.786
ATRATR 0.846 0.051 1 0.821
NLKNLK 0.846 0.029 1 0.762
NIKNIK 0.846 0.169 -3 0.816
PKACGPKACG 0.846 0.141 -2 0.829
NUAK2NUAK2 0.846 0.119 -3 0.806
DAPK2DAPK2 0.846 0.149 -3 0.795
CAMLCKCAMLCK 0.846 0.118 -2 0.893
TSSK2TSSK2 0.845 0.194 -5 0.886
P70S6KBP70S6KB 0.845 0.104 -3 0.752
CAMK2GCAMK2G 0.845 -0.028 2 0.846
PDHK4PDHK4 0.844 -0.173 1 0.813
GCN2GCN2 0.844 -0.138 2 0.825
RIPK3RIPK3 0.844 0.056 3 0.753
AMPKA1AMPKA1 0.844 0.139 -3 0.817
MTORMTOR 0.844 -0.092 1 0.725
ULK2ULK2 0.843 -0.071 2 0.814
PAK6PAK6 0.843 0.227 -2 0.776
MNK2MNK2 0.843 0.204 -2 0.848
TSSK1TSSK1 0.843 0.202 -3 0.827
IKKBIKKB 0.843 -0.116 -2 0.777
LATS2LATS2 0.843 0.064 -5 0.762
CAMK4CAMK4 0.842 0.125 -3 0.799
CAMK2BCAMK2B 0.842 0.122 2 0.817
PKCDPKCD 0.842 0.130 2 0.830
PKACBPKACB 0.842 0.176 -2 0.766
BMPR2BMPR2 0.842 -0.121 -2 0.884
TBK1TBK1 0.842 -0.072 1 0.706
MARK4MARK4 0.842 0.065 4 0.840
ERK5ERK5 0.841 0.001 1 0.719
CDKL1CDKL1 0.841 -0.004 -3 0.706
MELKMELK 0.840 0.149 -3 0.788
PAK1PAK1 0.839 0.125 -2 0.829
PAK3PAK3 0.839 0.115 -2 0.837
IKKEIKKE 0.839 -0.091 1 0.709
TGFBR2TGFBR2 0.839 -0.008 -2 0.800
AMPKA2AMPKA2 0.838 0.118 -3 0.798
CAMK2ACAMK2A 0.838 0.110 2 0.824
PDHK1PDHK1 0.838 -0.160 1 0.804
AURBAURB 0.838 0.162 -2 0.740
PRKXPRKX 0.838 0.194 -3 0.694
NEK6NEK6 0.838 -0.032 -2 0.840
PKG2PKG2 0.838 0.177 -2 0.778
SRPK1SRPK1 0.838 0.037 -3 0.668
MYLK4MYLK4 0.837 0.127 -2 0.840
NEK7NEK7 0.837 -0.089 -3 0.766
WNK3WNK3 0.837 -0.033 1 0.776
HUNKHUNK 0.837 -0.041 2 0.819
HIPK4HIPK4 0.836 0.025 1 0.737
ATMATM 0.836 0.048 1 0.781
NIM1NIM1 0.835 0.029 3 0.759
SGK3SGK3 0.835 0.151 -3 0.737
MNK1MNK1 0.835 0.186 -2 0.865
CHK1CHK1 0.835 0.173 -3 0.794
RSK4RSK4 0.835 0.093 -3 0.688
CLK1CLK1 0.834 0.128 -3 0.732
BCKDKBCKDK 0.834 -0.093 -1 0.817
MSK2MSK2 0.834 0.024 -3 0.662
NUAK1NUAK1 0.834 0.081 -3 0.771
CLK4CLK4 0.834 0.105 -3 0.727
CDKL5CDKL5 0.834 -0.015 -3 0.700
GRK6GRK6 0.833 -0.040 1 0.828
NEK9NEK9 0.833 -0.030 2 0.859
BMPR1BBMPR1B 0.833 0.109 1 0.825
QIKQIK 0.833 0.069 -3 0.794
MSK1MSK1 0.833 0.080 -3 0.680
GRK5GRK5 0.833 -0.146 -3 0.740
FAM20CFAM20C 0.833 0.097 2 0.677
RIPK1RIPK1 0.833 -0.027 1 0.775
PKCGPKCG 0.833 0.110 2 0.787
PKCBPKCB 0.832 0.110 2 0.781
SIKSIK 0.832 0.079 -3 0.736
TGFBR1TGFBR1 0.832 0.072 -2 0.818
ULK1ULK1 0.832 -0.141 -3 0.727
LATS1LATS1 0.831 0.087 -3 0.785
CHAK2CHAK2 0.831 -0.035 -1 0.831
PKACAPKACA 0.831 0.153 -2 0.730
NEK2NEK2 0.831 0.065 2 0.843
ALK4ALK4 0.830 0.038 -2 0.845
ICKICK 0.830 -0.011 -3 0.747
GRK1GRK1 0.830 -0.023 -2 0.783
DNAPKDNAPK 0.830 0.096 1 0.721
AKT2AKT2 0.830 0.094 -3 0.659
QSKQSK 0.829 0.063 4 0.812
PKCAPKCA 0.829 0.099 2 0.778
PHKG1PHKG1 0.829 0.063 -3 0.793
PIM2PIM2 0.829 0.094 -3 0.708
MASTLMASTL 0.829 -0.199 -2 0.811
SRPK2SRPK2 0.829 0.010 -3 0.600
MLK1MLK1 0.829 -0.126 2 0.846
KISKIS 0.829 -0.015 1 0.611
PKRPKR 0.828 0.075 1 0.809
ANKRD3ANKRD3 0.828 -0.079 1 0.819
IKKAIKKA 0.828 -0.095 -2 0.750
DCAMKL1DCAMKL1 0.827 0.140 -3 0.784
SMG1SMG1 0.827 0.038 1 0.781
MLK2MLK2 0.826 -0.078 2 0.843
PKCHPKCH 0.826 0.076 2 0.771
BRSK1BRSK1 0.826 0.028 -3 0.759
PAK2PAK2 0.826 0.048 -2 0.817
AURAAURA 0.826 0.087 -2 0.703
CLK2CLK2 0.825 0.115 -3 0.705
PLK1PLK1 0.825 -0.038 -2 0.801
DLKDLK 0.825 -0.165 1 0.797
MARK3MARK3 0.825 0.064 4 0.775
CAMK1GCAMK1G 0.825 0.053 -3 0.720
CAMK1DCAMK1D 0.825 0.118 -3 0.688
IRE1IRE1 0.825 -0.038 1 0.753
CDK18CDK18 0.824 0.048 1 0.536
MAPKAPK5MAPKAPK5 0.824 -0.051 -3 0.650
CDK7CDK7 0.824 -0.018 1 0.606
MARK2MARK2 0.824 0.052 4 0.750
ALK2ALK2 0.824 0.046 -2 0.824
ACVR2BACVR2B 0.823 0.025 -2 0.805
DYRK2DYRK2 0.823 -0.004 1 0.646
PKCZPKCZ 0.823 0.053 2 0.820
MEK1MEK1 0.823 -0.081 2 0.840
SMMLCKSMMLCK 0.823 0.098 -3 0.755
SNRKSNRK 0.822 -0.037 2 0.723
DCAMKL2DCAMKL2 0.822 0.121 -3 0.809
BRSK2BRSK2 0.822 0.010 -3 0.797
MARK1MARK1 0.822 0.046 4 0.797
IRE2IRE2 0.822 -0.025 2 0.797
ACVR2AACVR2A 0.821 0.007 -2 0.794
CDK8CDK8 0.821 -0.059 1 0.594
TTBK2TTBK2 0.821 -0.163 2 0.730
SSTKSSTK 0.821 0.133 4 0.802
AKT1AKT1 0.820 0.102 -3 0.695
DAPK3DAPK3 0.820 0.163 -3 0.765
SRPK3SRPK3 0.820 -0.028 -3 0.625
GRK4GRK4 0.820 -0.189 -2 0.811
P70S6KP70S6K 0.820 0.029 -3 0.663
PHKG2PHKG2 0.819 0.102 -3 0.804
BRAFBRAF 0.819 0.021 -4 0.811
DRAK1DRAK1 0.819 0.004 1 0.776
PAK5PAK5 0.818 0.131 -2 0.700
HIPK1HIPK1 0.818 0.041 1 0.658
MLK3MLK3 0.818 -0.063 2 0.787
YSK4YSK4 0.818 -0.095 1 0.747
JNK2JNK2 0.818 0.014 1 0.548
VRK2VRK2 0.818 -0.166 1 0.819
PKCTPKCT 0.817 0.078 2 0.776
CDK19CDK19 0.817 -0.047 1 0.556
BMPR1ABMPR1A 0.817 0.072 1 0.813
CHAK1CHAK1 0.815 -0.090 2 0.806
WNK4WNK4 0.815 0.015 -2 0.855
BUB1BUB1 0.815 0.264 -5 0.871
PKCIPKCI 0.815 0.098 2 0.788
PAK4PAK4 0.815 0.121 -2 0.704
CHK2CHK2 0.814 0.088 -3 0.634
NEK5NEK5 0.814 0.026 1 0.784
CDK13CDK13 0.814 -0.050 1 0.574
CAMK1ACAMK1A 0.814 0.112 -3 0.650
P38AP38A 0.814 -0.019 1 0.620
IRAK4IRAK4 0.813 0.025 1 0.756
MST3MST3 0.813 0.077 2 0.858
HIPK2HIPK2 0.813 0.018 1 0.558
CDK14CDK14 0.813 0.040 1 0.580
PLK3PLK3 0.813 -0.109 2 0.795
CDK17CDK17 0.813 -0.002 1 0.487
CDK5CDK5 0.812 -0.018 1 0.624
CDK9CDK9 0.812 -0.038 1 0.580
PLK4PLK4 0.812 -0.065 2 0.659
DAPK1DAPK1 0.812 0.113 -3 0.734
HIPK3HIPK3 0.812 0.013 1 0.641
PERKPERK 0.812 -0.092 -2 0.833
GRK7GRK7 0.811 -0.046 1 0.744
TLK2TLK2 0.811 -0.114 1 0.779
PKN1PKN1 0.811 0.069 -3 0.703
HRIHRI 0.811 -0.128 -2 0.850
MLK4MLK4 0.811 -0.110 2 0.759
CDK2CDK2 0.811 -0.057 1 0.655
GRK2GRK2 0.811 -0.062 -2 0.722
PKCEPKCE 0.810 0.103 2 0.775
MRCKBMRCKB 0.810 0.138 -3 0.722
PINK1PINK1 0.810 -0.130 1 0.765
PRP4PRP4 0.809 -0.023 -3 0.667
JNK3JNK3 0.809 -0.040 1 0.578
P38BP38B 0.809 -0.023 1 0.550
SGK1SGK1 0.809 0.077 -3 0.578
ROCK2ROCK2 0.809 0.171 -3 0.766
CDK16CDK16 0.809 0.032 1 0.503
CDK12CDK12 0.808 -0.039 1 0.545
DYRK1ADYRK1A 0.808 -0.029 1 0.659
DYRK3DYRK3 0.808 0.024 1 0.669
MEKK1MEKK1 0.808 -0.127 1 0.767
CDK10CDK10 0.808 0.038 1 0.566
SBKSBK 0.807 0.059 -3 0.562
DYRK4DYRK4 0.807 -0.001 1 0.567
AKT3AKT3 0.807 0.069 -3 0.597
LKB1LKB1 0.807 0.018 -3 0.772
MEK5MEK5 0.807 -0.194 2 0.839
MRCKAMRCKA 0.807 0.118 -3 0.743
PASKPASK 0.807 -0.014 -3 0.763
CDK1CDK1 0.806 -0.052 1 0.570
TLK1TLK1 0.806 -0.107 -2 0.819
TAO3TAO3 0.806 0.012 1 0.758
ERK1ERK1 0.806 -0.041 1 0.541
NEK4NEK4 0.806 0.046 1 0.756
CAMKK1CAMKK1 0.806 -0.078 -2 0.786
P38GP38G 0.805 -0.029 1 0.481
CK2A2CK2A2 0.805 0.053 1 0.782
ZAKZAK 0.805 -0.147 1 0.742
MPSK1MPSK1 0.805 0.007 1 0.744
CK1ECK1E 0.805 -0.070 -3 0.459
DYRK1BDYRK1B 0.804 -0.013 1 0.588
GAKGAK 0.804 0.042 1 0.813
DMPK1DMPK1 0.804 0.187 -3 0.762
TAO2TAO2 0.804 0.014 2 0.883
MEKK3MEKK3 0.804 -0.186 1 0.770
ERK2ERK2 0.803 -0.067 1 0.580
MEKK2MEKK2 0.803 -0.138 2 0.826
PKG1PKG1 0.802 0.113 -2 0.709
IRAK1IRAK1 0.802 -0.151 -1 0.775
GSK3BGSK3B 0.802 -0.020 4 0.442
CAMKK2CAMKK2 0.802 -0.080 -2 0.786
HPK1HPK1 0.801 0.090 1 0.767
NEK1NEK1 0.800 0.073 1 0.756
CDK3CDK3 0.799 -0.024 1 0.508
NEK8NEK8 0.799 -0.108 2 0.855
P38DP38D 0.799 -0.015 1 0.504
GCKGCK 0.799 0.032 1 0.780
MEKK6MEKK6 0.799 -0.005 1 0.742
NEK11NEK11 0.799 -0.120 1 0.748
CK1A2CK1A2 0.799 -0.056 -3 0.418
LOKLOK 0.798 0.070 -2 0.817
TNIKTNIK 0.798 0.046 3 0.812
ROCK1ROCK1 0.798 0.147 -3 0.740
TTBK1TTBK1 0.797 -0.162 2 0.656
PBKPBK 0.797 0.079 1 0.738
CK1DCK1D 0.796 -0.072 -3 0.417
PDK1PDK1 0.796 -0.074 1 0.740
HGKHGK 0.796 -0.006 3 0.810
ERK7ERK7 0.796 0.037 2 0.610
MINKMINK 0.796 -0.002 1 0.762
MAP3K15MAP3K15 0.796 -0.038 1 0.721
CK1G1CK1G1 0.796 -0.095 -3 0.445
TAK1TAK1 0.795 -0.059 1 0.794
GSK3AGSK3A 0.795 -0.021 4 0.451
KHS1KHS1 0.795 0.092 1 0.754
MST2MST2 0.795 -0.085 1 0.783
CK2A1CK2A1 0.794 0.034 1 0.767
KHS2KHS2 0.794 0.108 1 0.771
GRK3GRK3 0.794 -0.083 -2 0.674
LRRK2LRRK2 0.793 -0.053 2 0.880
CRIKCRIK 0.792 0.079 -3 0.676
EEF2KEEF2K 0.792 -0.062 3 0.761
PDHK3_TYRPDHK3_TYR 0.792 0.185 4 0.895
MAKMAK 0.789 0.010 -2 0.706
MOKMOK 0.789 0.011 1 0.675
MST1MST1 0.788 -0.072 1 0.764
CDK6CDK6 0.788 -0.029 1 0.556
YSK1YSK1 0.788 -0.005 2 0.835
STK33STK33 0.788 -0.098 2 0.652
CDK4CDK4 0.788 -0.027 1 0.538
SLKSLK 0.788 -0.015 -2 0.742
VRK1VRK1 0.788 -0.126 2 0.860
NEK3NEK3 0.787 -0.028 1 0.702
MEK2MEK2 0.787 -0.153 2 0.812
JNK1JNK1 0.786 -0.065 1 0.543
RIPK2RIPK2 0.786 -0.191 1 0.702
PLK2PLK2 0.784 -0.104 -3 0.654
HASPINHASPIN 0.783 0.116 -1 0.801
TESK1_TYRTESK1_TYR 0.783 0.017 3 0.850
BIKEBIKE 0.781 0.063 1 0.699
LIMK2_TYRLIMK2_TYR 0.781 0.126 -3 0.830
PDHK4_TYRPDHK4_TYR 0.781 0.018 2 0.895
MAP2K4_TYRMAP2K4_TYR 0.780 -0.041 -1 0.869
EPHA6EPHA6 0.780 0.093 -1 0.849
PKMYT1_TYRPKMYT1_TYR 0.780 -0.018 3 0.833
MAP2K6_TYRMAP2K6_TYR 0.777 -0.069 -1 0.864
TTKTTK 0.777 -0.031 -2 0.803
MAP2K7_TYRMAP2K7_TYR 0.777 -0.146 2 0.883
MYO3BMYO3B 0.777 0.004 2 0.854
BMPR2_TYRBMPR2_TYR 0.776 -0.042 -1 0.855
EPHB4EPHB4 0.775 0.032 -1 0.840
PINK1_TYRPINK1_TYR 0.774 -0.128 1 0.790
TNK2TNK2 0.773 0.110 3 0.786
PDHK1_TYRPDHK1_TYR 0.772 -0.133 -1 0.869
ASK1ASK1 0.772 -0.100 1 0.708
TAO1TAO1 0.772 -0.029 1 0.682
RETRET 0.771 -0.063 1 0.755
MYO3AMYO3A 0.770 -0.043 1 0.751
LIMK1_TYRLIMK1_TYR 0.770 -0.087 2 0.883
OSR1OSR1 0.769 -0.140 2 0.808
MST1RMST1R 0.769 -0.057 3 0.809
TYRO3TYRO3 0.769 -0.049 3 0.775
AAK1AAK1 0.768 0.098 1 0.598
TXKTXK 0.768 0.052 1 0.844
DDR1DDR1 0.768 -0.055 4 0.805
ABL2ABL2 0.768 -0.000 -1 0.820
ROS1ROS1 0.767 -0.052 3 0.751
TYK2TYK2 0.766 -0.119 1 0.750
ABL1ABL1 0.766 -0.003 -1 0.811
EPHB3EPHB3 0.765 -0.003 -1 0.829
AXLAXL 0.764 0.025 3 0.793
EPHA4EPHA4 0.764 -0.023 2 0.797
YANK3YANK3 0.764 -0.080 2 0.431
JAK2JAK2 0.764 -0.113 1 0.740
EPHB1EPHB1 0.764 -0.028 1 0.819
EPHB2EPHB2 0.763 -0.005 -1 0.817
SRMSSRMS 0.763 -0.030 1 0.834
CSF1RCSF1R 0.763 -0.095 3 0.790
FERFER 0.762 -0.119 1 0.842
TNK1TNK1 0.762 0.035 3 0.764
MERTKMERTK 0.762 0.012 3 0.790
YES1YES1 0.762 -0.074 -1 0.831
INSRRINSRR 0.761 -0.080 3 0.742
FGRFGR 0.760 -0.126 1 0.808
HCKHCK 0.759 -0.072 -1 0.818
JAK3JAK3 0.759 -0.127 1 0.734
ITKITK 0.759 -0.062 -1 0.802
ALPHAK3ALPHAK3 0.759 -0.150 -1 0.758
CK1ACK1A 0.759 -0.100 -3 0.332
EPHA7EPHA7 0.758 -0.005 2 0.805
PDGFRBPDGFRB 0.758 -0.116 3 0.792
LCKLCK 0.758 -0.037 -1 0.813
BLKBLK 0.757 0.004 -1 0.828
JAK1JAK1 0.757 -0.017 1 0.697
EPHA1EPHA1 0.757 0.011 3 0.785
FGFR2FGFR2 0.757 -0.123 3 0.803
TNNI3K_TYRTNNI3K_TYR 0.757 -0.025 1 0.747
KDRKDR 0.756 -0.069 3 0.770
NEK10_TYRNEK10_TYR 0.756 -0.069 1 0.634
TECTEC 0.756 -0.030 -1 0.766
BMXBMX 0.756 -0.037 -1 0.744
PTK2BPTK2B 0.755 0.024 -1 0.790
TEKTEK 0.755 -0.117 3 0.730
EPHA3EPHA3 0.754 -0.063 2 0.776
STLK3STLK3 0.754 -0.209 1 0.715
KITKIT 0.754 -0.142 3 0.794
LTKLTK 0.753 -0.073 3 0.734
FLT3FLT3 0.753 -0.142 3 0.778
FGFR1FGFR1 0.752 -0.139 3 0.771
EPHA5EPHA5 0.751 -0.018 2 0.788
ALKALK 0.751 -0.102 3 0.702
DDR2DDR2 0.750 -0.006 3 0.738
WEE1_TYRWEE1_TYR 0.750 -0.078 -1 0.761
NTRK1NTRK1 0.750 -0.152 -1 0.812
PDGFRAPDGFRA 0.750 -0.166 3 0.781
METMET 0.750 -0.123 3 0.795
BTKBTK 0.749 -0.162 -1 0.778
FRKFRK 0.747 -0.092 -1 0.843
FYNFYN 0.746 -0.070 -1 0.788
NTRK2NTRK2 0.745 -0.162 3 0.758
FGFR3FGFR3 0.744 -0.153 3 0.781
FLT4FLT4 0.744 -0.165 3 0.759
EPHA8EPHA8 0.744 -0.073 -1 0.811
ERBB2ERBB2 0.743 -0.184 1 0.728
LYNLYN 0.743 -0.115 3 0.712
INSRINSR 0.743 -0.156 3 0.723
FLT1FLT1 0.742 -0.182 -1 0.803
PTK6PTK6 0.742 -0.218 -1 0.730
NTRK3NTRK3 0.742 -0.132 -1 0.770
MATKMATK 0.740 -0.130 -1 0.745
PTK2PTK2 0.737 -0.025 -1 0.744
CSKCSK 0.737 -0.150 2 0.803
CK1G3CK1G3 0.736 -0.113 -3 0.287
SRCSRC 0.736 -0.121 -1 0.791
EPHA2EPHA2 0.736 -0.071 -1 0.771
EGFREGFR 0.735 -0.125 1 0.634
MUSKMUSK 0.732 -0.123 1 0.622
FGFR4FGFR4 0.731 -0.142 -1 0.758
SYKSYK 0.729 -0.087 -1 0.746
YANK2YANK2 0.729 -0.112 2 0.450
ERBB4ERBB4 0.727 -0.086 1 0.669
IGF1RIGF1R 0.726 -0.170 3 0.664
FESFES 0.719 -0.124 -1 0.711
CK1G2CK1G2 0.714 -0.126 -3 0.374
ZAP70ZAP70 0.706 -0.109 -1 0.685