Motif 724 (n=328)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0J9YX86 GOLGA8Q Y150 ochoa Golgin A8 family member Q None
A0AVK6 E2F8 S102 ochoa Transcription factor E2F8 (E2F-8) Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:16179649, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:22903062}.
A0JNW5 BLTP3B S1066 ochoa Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}.
B2RTY4 MYO9A S1299 ochoa Unconventional myosin-IXa (Unconventional myosin-9a) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}.
I6L899 GOLGA8R Y150 ochoa Golgin subfamily A member 8R None
O00534 VWA5A S202 ochoa von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein) May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.
O14686 KMT2D S2640 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14686 KMT2D S3229 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14776 TCERG1 S853 ochoa Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. {ECO:0000269|PubMed:11604498, ECO:0000269|PubMed:9315662}.
O14929 HAT1 S343 ochoa Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:20953179, PubMed:23653357, PubMed:31278053, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:11585814, PubMed:22615379). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:23653357, ECO:0000269|PubMed:31278053, ECO:0000269|PubMed:31812350, ECO:0000269|PubMed:32081014}.; FUNCTION: (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell. {ECO:0000269|PubMed:31695772}.
O14958 CASQ2 S36 ochoa Calsequestrin-2 (Calsequestrin, cardiac muscle isoform) Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000269|PubMed:16908766, ECO:0000269|PubMed:17881003, ECO:0000269|PubMed:18399795, ECO:0000269|PubMed:21416293}.
O14974 PPP1R12A S888 ochoa Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.
O15069 NACAD S1133 ochoa NAC-alpha domain-containing protein 1 May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}.
O15091 PRORP S98 ochoa Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit) Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853). {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:25953853, ECO:0000269|PubMed:34715011}.
O15360 FANCA S695 ochoa Fanconi anemia group A protein (Protein FACA) DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
O15530 PDPK1 S410 psp 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}.
O43432 EIF4G3 S371 ochoa Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}.
O43488 AKR7A2 S121 ochoa Aflatoxin B1 aldehyde reductase member 2 (EC 1.1.1.n11) (AFB1 aldehyde reductase 1) (AFB1-AR 1) (Aldoketoreductase 7) (Succinic semialdehyde reductase) (SSA reductase) Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:17591773, ECO:0000269|PubMed:9576847}.
O43707 ACTN4 S621 ochoa Alpha-actinin-4 (Non-muscle alpha-actinin 4) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}.
O43772 SLC25A20 S143 ochoa Mitochondrial carnitine/acylcarnitine carrier protein (Carnitine/acylcarnitine translocase) (CAC) (CACT) (Solute carrier family 25 member 20) Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (Probable) (PubMed:12892634, PubMed:18307102). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) (PubMed:18307102). {ECO:0000269|PubMed:12892634, ECO:0000269|PubMed:18307102, ECO:0000305|PubMed:18307102, ECO:0000305|PubMed:20347717}.
O60216 RAD21 S175 ochoa|psp Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:Q61550, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:25575569, ECO:0000305|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}.
O60282 KIF5C S835 ochoa Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1) Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). {ECO:0000250|UniProtKB:P28738, ECO:0000250|UniProtKB:P56536, ECO:0000269|PubMed:24812067}.
O60341 KDM1A S687 psp Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:29358331, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:34655521, ECO:0000269|PubMed:34906447}.
O60503 ADCY9 S691 ochoa Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}.
O60664 PLIN3 S91 ochoa Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}.
O60749 SNX2 S227 ochoa Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:20138391, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:23085988, ECO:0000303|PubMed:16179610}.
O60814 H2BC12 S65 ochoa Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
O60832 DKC1 S21 ochoa H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}.
O75400 PRPF40A S933 ochoa Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}.
O75691 UTP20 S2548 ochoa Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}.
O75762 TRPA1 S86 psp Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}.
O95613 PCNT S3287 ochoa Pericentrin (Kendrin) (Pericentrin-B) Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}.
P02647 APOA1 S55 ochoa Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}.
P02675 FGB Y182 psp Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
P02730 SLC4A1 S303 psp Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}.
P02794 FTH1 S114 ochoa Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (PubMed:24695223, PubMed:26436293). {ECO:0000250|UniProtKB:P09528, ECO:0000269|PubMed:24695223, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:9003196}.
P04632 CAPNS1 S88 ochoa Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:O88456}.
P05023 ATP1A1 S47 ochoa Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}.
P06401 PGR S102 ochoa|psp Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
P09467 FBP1 S144 ochoa|psp Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}.
P09496 CLTA S105 ochoa Clathrin light chain A (Lca) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582). {ECO:0000305|PubMed:15858577, ECO:0000305|PubMed:21297582}.
P10412 H1-4 Y71 ochoa Histone H1.4 (Histone H1b) (Histone H1s-4) Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P10721 KIT S746 psp Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}.
P11277 SPTB S1829 ochoa Spectrin beta chain, erythrocytic (Beta-I spectrin) Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
P12883 MYH7 S1412 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13861 PRKAR2A S383 ochoa cAMP-dependent protein kinase type II-alpha regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
P15822 HIVEP1 S1180 ochoa Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
P16402 H1-3 Y72 ochoa Histone H1.3 (Histone H1c) (Histone H1s-2) Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16403 H1-2 Y71 ochoa Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P17480 UBTF S364 ochoa Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}.
P17861 XBP1 S96 ochoa X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form] Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Also functions as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:8349596}.; FUNCTION: [Isoform 1]: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:1903538, PubMed:2196176, PubMed:2321018, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:1903538, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:21233347, ECO:0000269|PubMed:2196176, ECO:0000269|PubMed:2321018, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:8657566}.; FUNCTION: [Isoform 2]: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Also improves glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:15466483, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:25280941}.
P19484 TFEB S151 ochoa Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}.
P21283 ATP6V1C1 S362 ochoa V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). {ECO:0000250|UniProtKB:P21282, ECO:0000250|UniProtKB:P31412, ECO:0000269|PubMed:33065002}.
P21673 SAT1 S149 psp Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1) Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632). Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine (PubMed:17516632). This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (PubMed:16455797). Also involved in the regulation of polyamine transport out of cells (PubMed:16455797). Also acts on 1,3-diaminopropane and 1,5-diaminopentane (PubMed:16455797, PubMed:17516632). {ECO:0000269|PubMed:15283699, ECO:0000269|PubMed:16455797, ECO:0000269|PubMed:17516632}.
P22492 H1-6 Y75 ochoa Histone H1t (Testicular H1 histone) Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable). {ECO:0000269|PubMed:26757249, ECO:0000305}.
P23528 CFL1 S24 ochoa|psp Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform) Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). {ECO:0000250|UniProtKB:P18760, ECO:0000269|PubMed:11812157, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677}.
P23588 EIF4B S131 ochoa Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P27824 CANX S564 ochoa|psp Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
P28290 ITPRID2 S650 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P33176 KIF5B S833 ochoa Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}.
P35222 CTNNB1 S605 psp Catenin beta-1 (Beta-catenin) Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}.
P41002 CCNF S577 psp Cyclin-F (F-box only protein 1) Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20596027, PubMed:22632967, PubMed:26818844, PubMed:27080313, PubMed:27653696, PubMed:28852778). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (PubMed:20596027, PubMed:26818844, PubMed:27653696, PubMed:8706131). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (PubMed:20596027, PubMed:22632967, PubMed:26818844, PubMed:27653696). Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (PubMed:20596027). In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity (PubMed:22632967). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (PubMed:26818844). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (PubMed:27653696). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (PubMed:25557911). {ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:22632967, ECO:0000269|PubMed:25557911, ECO:0000269|PubMed:26818844, ECO:0000269|PubMed:27080313, ECO:0000269|PubMed:27653696, ECO:0000269|PubMed:28852778, ECO:0000269|PubMed:8706131}.
P42224 STAT1 S708 psp Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:12764129, PubMed:12855578, PubMed:15322115, PubMed:23940278, PubMed:34508746, PubMed:35568036, PubMed:9724754). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426, PubMed:35568036). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state (PubMed:28753426, PubMed:35568036). In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state (PubMed:8156998). Becomes activated in response to KITLG/SCF and KIT signaling (PubMed:15526160). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:19088846). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylated at Thr-749 by IKBKB which promotes binding of STAT1 to the 5'-TTTGAGGC-3' sequence in the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). Phosphorylation at Thr-749 also promotes binding of STAT1 to the 5'-TTTGAGTC-3' sequence in the IL12B promoter and activation of IL12B transcription (PubMed:32209697). Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine (By similarity). {ECO:0000250|UniProtKB:P42225, ECO:0000269|PubMed:12764129, ECO:0000269|PubMed:12855578, ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:23940278, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:34508746, ECO:0000269|PubMed:35568036, ECO:0000269|PubMed:8156998, ECO:0000269|PubMed:9724754, ECO:0000303|PubMed:15526160}.
P42695 NCAPD3 S530 ochoa Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}.
P43243 MATR3 S276 ochoa Matrin-3 May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}.
P47710 CSN1S1 S90 psp Alpha-S1-casein [Cleaved into: Casoxin-D] Important role in the capacity of milk to transport calcium phosphate.; FUNCTION: Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.
P49366 DHPS S78 ochoa Deoxyhypusine synthase (DHS) (EC 2.5.1.46) Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. {ECO:0000269|PubMed:30661771}.
P49368 CCT3 S333 ochoa T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
P49815 TSC2 S1002 ochoa Tuberin (Tuberous sclerosis 2 protein) Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}.
P50990 CCT8 S23 ochoa T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
P52292 KPNA2 S88 ochoa Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}.
P54296 MYOM2 S76 ochoa|psp Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P54296 MYOM2 S1272 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P55087 AQP4 S276 ochoa|psp Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) Forms a water-specific channel (PubMed:19383790, PubMed:7559426, PubMed:8601457). Plays an important role in brain water homeostasis (PubMed:37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). {ECO:0000250|UniProtKB:P55088, ECO:0000269|PubMed:19383790, ECO:0000269|PubMed:37143309, ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}.
P55196 AFDN S424 ochoa Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}.
P57053 H2BC12L S65 ochoa Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
P58876 H2BC5 S65 ochoa Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P60981 DSTN S24 ochoa Destrin (Actin-depolymerizing factor) (ADF) Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. {ECO:0000269|PubMed:11812157}.
P61313 RPL15 S100 ochoa Large ribosomal subunit protein eL15 (60S ribosomal protein L15) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
P62807 H2BC4 S65 ochoa Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
P84090 ERH S24 ochoa Enhancer of rudimentary homolog May have a role in the cell cycle.
P98082 DAB2 S24 ochoa|psp Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}.
Q00610 CLTC S1167 ochoa Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
Q01484 ANK2 S1732 ochoa Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}.
Q01804 OTUD4 S443 ochoa OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}.
Q02539 H1-1 Y74 ochoa Histone H1.1 (Histone H1a) Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
Q02543 RPL18A S57 ochoa Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
Q03001 DST S2514 ochoa Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
Q03164 KMT2A S2508 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q05209 PTPN12 S661 ochoa Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.
Q0IIM8 TBC1D8B S539 ochoa TBC1 domain family member 8B Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein. {ECO:0000269|PubMed:30661770}.
Q12802 AKAP13 S2345 ochoa A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q12840 KIF5A S831 ochoa Kinesin heavy chain isoform 5A (EC 5.6.1.3) (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. {ECO:0000250|UniProtKB:P33175, ECO:0000250|UniProtKB:Q6QLM7}.
Q12888 TP53BP1 S323 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13085 ACACA S23 ochoa Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.
Q13164 MAPK7 S567 psp Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
Q13200 PSMD2 S29 ochoa 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
Q13315 ATM S1403 psp Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}.
Q13315 ATM S1988 ochoa|psp Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}.
Q13439 GOLGA4 S1514 ochoa Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}.
Q13586 STIM1 S567 ochoa Stromal interaction molecule 1 Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}.
Q13596 SNX1 S230 ochoa Sorting nexin-1 Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}.
Q13625 TP53BP2 S737 ochoa Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Q13772 NCOA4 S553 ochoa Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}.
Q13873 BMPR2 S765 ochoa Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}.
Q14141 SEPTIN6 S319 ochoa Septin-6 Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}.
Q14155 ARHGEF7 S25 ochoa Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.
Q14562 DHX8 S395 ochoa ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}.
Q14667 BLTP2 S1846 ochoa Bridge-like lipid transfer protein family member 2 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) (Protein hobbit homolog) Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution. {ECO:0000250|UniProtKB:Q9VZS7}.
Q14674 ESPL1 S1660 psp Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}.
Q14766 LTBP1 S1413 ochoa Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}.
Q14789 GOLGB1 S38 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q15032 R3HDM1 S141 ochoa R3H domain-containing protein 1 None
Q15058 KIF14 S105 ochoa Kinesin-like protein KIF14 Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}.
Q15276 RABEP1 S362 ochoa Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}.
Q15345 LRRC41 S326 ochoa Leucine-rich repeat-containing protein 41 (Protein Muf1) Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}.
Q15382 RHEB S130 psp GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:12906785, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:22819219, PubMed:24529379, PubMed:29416044, PubMed:32470140, PubMed:33157014, PubMed:25816988). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:29236692, PubMed:33157014). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059). {ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0000269|PubMed:33157014}.
Q15398 DLGAP5 S787 ochoa Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}.
Q15583 TGIF1 S140 ochoa Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1) Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Q15772 SPEG S453 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q16584 MAP3K11 S394 ochoa Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}.
Q16778 H2BC21 S65 ochoa Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Q16799 RTN1 S350 ochoa Reticulon-1 (Neuroendocrine-specific protein) Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}.
Q16825 PTPN21 S616 ochoa Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) None
Q16875 PFKFB3 S478 ochoa|psp 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:10077634, ECO:0000269|PubMed:17499765, ECO:0000305|PubMed:16316985}.
Q16890 TPD52L1 S174 ochoa Tumor protein D53 (hD53) (Tumor protein D52-like 1) None
Q2M389 WASHC4 S1097 ochoa WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP) Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000303|PubMed:21498477}.
Q32NC0 C18orf21 S195 ochoa UPF0711 protein C18orf21 (HBV X-transactivated gene 13 protein) (HBV XAg-transactivated protein 13) None
Q49A26 GLYR1 S223 ochoa Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}.
Q49A88 CCDC14 S124 ochoa Coiled-coil domain-containing protein 14 Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}.
Q4G0J3 LARP7 S337 ochoa La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}.
Q52LW3 ARHGAP29 S182 ochoa Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}.
Q53EU6 GPAT3 S77 ochoa Glycerol-3-phosphate acyltransferase 3 (GPAT-3) (EC 2.3.1.15) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10) (AGPAT 10) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9) (1-AGP acyltransferase 9) (1-AGPAT 9) (EC 2.3.1.51) (Acyl-CoA:glycerol-3-phosphate acyltransferase 3) (hGPAT3) (Lung cancer metastasis-associated protein 1) (Lysophosphatidic acid acyltransferase theta) (LPAAT-theta) (MAG-1) Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427). Protects cells against lipotoxicity (PubMed:30846318). {ECO:0000269|PubMed:17170135, ECO:0000269|PubMed:19318427, ECO:0000269|PubMed:30846318}.
Q53GL0 PLEKHO1 S271 ochoa Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}.
Q58EX2 SDK2 S1982 ochoa Protein sidekick-2 Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}.
Q5JSH3 WDR44 S66 ochoa WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}.
Q5QNW6 H2BC18 S65 ochoa Histone H2B type 2-F (H2B-clustered histone 18) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q5T035 FAM120A2P S45 ochoa Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene) None
Q5TAP6 UTP14C S442 ochoa U3 small nucleolar RNA-associated protein 14 homolog C Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15289605}.
Q5U3C3 TMEM164 S74 ochoa Transmembrane protein 164 (Arachidonoyl ether phospholipid synthase) Positive regulator of ferroptosis (PubMed:35947500, PubMed:36782012). Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20:4) of diacylglycerophospholipids, generating C20:4 ether glycerophospholipids (ePEs) such as 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine (PE (P-18:0/20:4)), which promotes ferroptosis (PubMed:36782012). Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death (PubMed:35947500). {ECO:0000269|PubMed:35947500, ECO:0000269|PubMed:36782012}.
Q5UIP0 RIF1 S1772 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5VTB9 RNF220 S200 ochoa E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220) E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658, PubMed:33964137). Plays a critical role in the regulation of nuclear lamina (PubMed:33964137). {ECO:0000250|UniProtKB:Q6PDX6, ECO:0000269|PubMed:25266658, ECO:0000269|PubMed:33964137}.
Q5VTR2 RNF20 S42 ochoa E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A) Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}.
Q5VWJ9 SNX30 S28 ochoa Sorting nexin-30 Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:32513819). Together with SNX4, involved in autophagosome assembly (PubMed:32513819). {ECO:0000269|PubMed:32513819}.
Q641Q2 WASHC2A S619 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q6F5E8 CARMIL2 S1362 ochoa Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}.
Q6KC79 NIPBL S850 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q6NWY9 PRPF40B S847 ochoa Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:9700202}.
Q6P4F7 ARHGAP11A S847 ochoa Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}.
Q6PHR2 ULK3 S219 ochoa Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}.
Q6PL18 ATAD2 S61 ochoa ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.
Q6WCQ1 MPRIP S677 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q6WKZ4 RAB11FIP1 S365 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6XZF7 DNMBP S516 ochoa Dynamin-binding protein (Scaffold protein Tuba) Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}.
Q6ZMZ3 SYNE3 S900 ochoa Nesprin-3 (KASH domain-containing protein 3) (KASH3) (Nuclear envelope spectrin repeat protein 3) As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. {ECO:0000269|PubMed:16330710, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:21937718}.
Q6ZNL6 FGD5 S740 ochoa FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}.
Q6ZS17 RIPOR1 S357 ochoa Rho family-interacting cell polarization regulator 1 Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}.
Q6ZU80 CEP128 S797 ochoa Centrosomal protein of 128 kDa (Cep128) None
Q6ZUM4 ARHGAP27 S481 ochoa Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}.
Q7L014 DDX46 S591 ochoa Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog) Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310, PubMed:36797247). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site (PubMed:34822310). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:36797247}.
Q7Z460 CLASP1 S1232 ochoa CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}.
Q7Z6B0 CCDC91 S416 ochoa Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein) Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}.
Q7Z7A1 CNTRL S1475 ochoa Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. {ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:16213214}.
Q7Z7B0 FILIP1 S138 ochoa Filamin-A-interacting protein 1 (FILIP) By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}.
Q86TP1 PRUNE1 S399 ochoa Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697, ECO:0000269|PubMed:28334956}.
Q86UZ6 ZBTB46 S326 ochoa Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340) Functions as a transcriptional repressor for PRDM1. {ECO:0000250}.
Q86V15 CASZ1 S130 ochoa Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}.
Q86WV6 STING1 S243 ochoa Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23747010, PubMed:23910378, PubMed:27801882, PubMed:29973723, PubMed:30842659, PubMed:35045565, PubMed:35388221, PubMed:36808561, PubMed:37832545, PubMed:25704810, PubMed:39255680). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed:26300263). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, cyclic UMP-AMP (2',3'-cUAMP), and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (PubMed:21947006, PubMed:23258412, PubMed:23707065, PubMed:23722158, PubMed:23747010, PubMed:23910378, PubMed:26229117, PubMed:30842659, PubMed:35388221, PubMed:37379839). Upon binding to c-di-GMP, cUAMP or cGAMP, STING1 oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state (PubMed:22394562, PubMed:25636800, PubMed:29973723, PubMed:30842653, PubMed:35045565, PubMed:35388221). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:23747010, PubMed:23910378, PubMed:26300263). The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free-ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation (PubMed:26150511). In addition to promote the production of type I interferons, plays a direct role in autophagy (PubMed:30568238, PubMed:30842662). Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (PubMed:30842662). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (PubMed:30842662). Promotes autophagy by acting as a proton channel that directs proton efflux from the Golgi to facilitate MAP1LC3B/LC3B lipidation (PubMed:37535724). The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (PubMed:30568238, PubMed:30842662). Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy (By similarity). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons (PubMed:18724357). May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) (By similarity). {ECO:0000250|UniProtKB:Q3TBT3, ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:19776740, ECO:0000269|PubMed:21947006, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:23258412, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722158, ECO:0000269|PubMed:23747010, ECO:0000269|PubMed:23910378, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:26150511, ECO:0000269|PubMed:26229117, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29973723, ECO:0000269|PubMed:30568238, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:30842659, ECO:0000269|PubMed:30842662, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35388221, ECO:0000269|PubMed:36808561, ECO:0000269|PubMed:37379839, ECO:0000269|PubMed:37535724, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:39255680}.; FUNCTION: (Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed:26405230). Such oncoproteins prevent the ability to sense cytosolic DNA (PubMed:26405230). {ECO:0000269|PubMed:26405230}.
Q86X29 LSR S436 ochoa Lipolysis-stimulated lipoprotein receptor (Angulin-1) Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}.
Q8IWJ2 GCC2 S446 ochoa GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}.
Q8IWZ3 ANKHD1 S208 ochoa Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}.
Q8IWZ3 ANKHD1 S887 ochoa Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}.
Q8IWZ3 ANKHD1 S1632 ochoa Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}.
Q8IXS8 HYCC2 S491 ochoa Hyccin 2 Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}.
Q8IY92 SLX4 S287 ochoa Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Q8IY95 TMEM192 S229 ochoa Transmembrane protein 192 None
Q8N257 H2BC26 S65 ochoa Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q8N4S9 MARVELD2 S146 ochoa MARVEL domain-containing protein 2 (Tricellulin) Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}.
Q8N697 SLC15A4 S279 ochoa Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1) Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). {ECO:0000250|UniProtKB:O09014, ECO:0000250|UniProtKB:Q91W98, ECO:0000269|PubMed:16289537, ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:32433612}.
Q8NCN2 ZBTB34 S459 ochoa Zinc finger and BTB domain-containing protein 34 May be a transcriptional repressor. {ECO:0000269|PubMed:16718364}.
Q8NCW6 GALNT11 S82 ochoa Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11) Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269|PubMed:11925450, ECO:0000269|PubMed:16207894, ECO:0000269|PubMed:24226769}.
Q8NER1 TRPV1 S117 psp Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:11050376, PubMed:11243859, PubMed:11226139, PubMed:12077606). Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activated by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius (PubMed:37117175). Upon activation, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. {ECO:0000250|UniProtKB:O35433, ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11226139, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:37117175}.
Q8NEV8 EXPH5 S1501 ochoa Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) May act as Rab effector protein and play a role in vesicle trafficking.
Q8NEV8 EXPH5 S1781 ochoa Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) May act as Rab effector protein and play a role in vesicle trafficking.
Q8NEY1 NAV1 S954 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8NFA0 USP32 Y671 ochoa Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874). {ECO:0000269|PubMed:36476874}.
Q8NFH8 REPS2 S217 ochoa RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}.
Q8TDI0 CHD5 S558 ochoa Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.-) (ATP-dependent helicase CHD5) ATP-dependent chromatin-remodeling factor that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. {ECO:0000250|UniProtKB:A2A8L1, ECO:0000269|PubMed:23948251}.
Q8TER5 ARHGEF40 S409 ochoa Rho guanine nucleotide exchange factor 40 (Protein SOLO) May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.
Q8WUM0 NUP133 S72 ochoa Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}.
Q8WUY9 DEPDC1B S436 ochoa DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8) None
Q8WVV4 POF1B S413 ochoa Protein POF1B (Premature ovarian failure protein 1B) Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}.
Q8WY36 BBX S886 ochoa HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}.
Q92575 UBXN4 S179 ochoa UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). {ECO:0000269|PubMed:16968747, ECO:0000269|PubMed:19822669}.
Q92610 ZNF592 S74 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q92614 MYO18A S806 ochoa Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.
Q92614 MYO18A S1068 ochoa Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.
Q92619 ARHGAP45 S878 ochoa Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}.
Q92785 DPF2 S142 ochoa Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}.
Q92793 CREBBP S1763 ochoa CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}.
Q92817 EVPL S1698 ochoa Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
Q93079 H2BC9 S65 ochoa Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q96AC1 FERMT2 S371 ochoa Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}.
Q96BD0 SLCO4A1 S356 ochoa Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:19129463, PubMed:30343886). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30343886, ECO:0000305}.
Q96JJ3 ELMO2 S336 ochoa Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:11703939, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:27476657}.
Q96JN2 CCDC136 S52 ochoa Coiled-coil domain-containing protein 136 (Nasopharyngeal carcinoma-associated gene 6 protein) May play a role in acrosome formation in spermatogenesis and in fertilization. {ECO:0000250|UniProtKB:Q3TVA9}.
Q96KQ4 PPP1R13B S710 ochoa Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540}.
Q96P48 ARAP1 S1428 ochoa Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (PubMed:11804590). Has a preference for ARF1 and ARF5 (PubMed:11804590, PubMed:19666464). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (PubMed:22573888). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (By similarity). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (By similarity). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (By similarity). Regulates the endocytic trafficking of EGFR (PubMed:18764928, PubMed:18939958, PubMed:21275903). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (By similarity). {ECO:0000250|UniProtKB:Q4LDD4, ECO:0000269|PubMed:11804590, ECO:0000269|PubMed:18764928, ECO:0000269|PubMed:18939958, ECO:0000269|PubMed:19666464, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:22573888, ECO:0000269|PubMed:38682696}.
Q96PD2 DCBLD2 S598 ochoa|psp Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein) None
Q96PE2 ARHGEF17 S567 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96RT1 ERBIN S714 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q96RT1 ERBIN S800 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q96S38 RPS6KC1 S209 ochoa Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}.
Q96S38 RPS6KC1 S596 ochoa Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}.
Q96T23 RSF1 S1345 ochoa Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}.
Q99567 NUP88 S437 ochoa Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}.
Q99640 PKMYT1 S100 ochoa Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}.
Q99733 NAP1L4 S22 ochoa Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}.
Q99877 H2BC15 S65 ochoa Histone H2B type 1-N (Histone H2B.d) (H2B/d) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q99879 H2BC14 S65 ochoa Histone H2B type 1-M (Histone H2B.e) (H2B/e) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q99880 H2BC13 S65 ochoa Histone H2B type 1-L (Histone H2B.c) (H2B/c) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q9BPX5 ARPC5L S91 ochoa Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Q9BQP7 MGME1 S71 ochoa Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-) Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endonuclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. {ECO:0000255|HAMAP-Rule:MF_03030, ECO:0000269|PubMed:23313956, ECO:0000269|PubMed:23358826}.
Q9BQS8 FYCO1 S609 ochoa FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}.
Q9BRF8 CPPED1 S294 ochoa Serine/threonine-protein phosphatase CPPED1 (EC 3.1.3.16) (Calcineurin-like phosphoesterase domain-containing protein 1) (Complete S-transactivated protein 1) Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. {ECO:0000269|PubMed:23799035, ECO:0000269|PubMed:23939394}.
Q9BSQ5 CCM2 S294 ochoa Cerebral cavernous malformations 2 protein (Malcavernin) Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}.
Q9BTT0 ANP32E S104 ochoa Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein) (LANP-L) Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269|PubMed:24463511}.
Q9BUR5 APOO S44 ochoa MICOS complex subunit MIC26 (Apolipoprotein O) (MICOS complex subunit MIC23) (Protein FAM121B) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892). {ECO:0000269|PubMed:16956892, ECO:0000269|PubMed:24743151, ECO:0000269|PubMed:25764979}.
Q9BW62 KATNAL1 S174 ochoa Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit A-like 1) (EC 5.6.1.1) (p60 katanin-like 1) Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (PubMed:26929214). {ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}.
Q9BWQ6 YIPF2 Y50 ochoa Protein YIPF2 (YIP1 family member 2) None
Q9BY89 KIAA1671 S1264 ochoa Uncharacterized protein KIAA1671 None
Q9BYB0 SHANK3 S1438 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9BYW2 SETD2 S1239 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9BZ72 PITPNM2 S399 ochoa Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}.
Q9BZI7 UPF3B S34 ochoa Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}.
Q9BZI7 UPF3B S176 ochoa Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}.
Q9GZY6 LAT2 S44 ochoa Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}.
Q9GZZ9 UBA5 S381 ochoa Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863}.
Q9H0B6 KLC2 S151 ochoa Kinesin light chain 2 (KLC 2) Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}.
Q9H1A4 ANAPC1 S60 ochoa Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9H1H9 KIF13A S1734 ochoa Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}.
Q9H2G2 SLK S818 ochoa STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}.
Q9H3R0 KDM4C S428 ochoa Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.
Q9H4L7 SMARCAD1 S146 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}.
Q9H4L7 SMARCAD1 S152 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}.
Q9H501 ESF1 S407 ochoa ESF1 homolog (ABT1-associated protein) May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}.
Q9H583 HEATR1 S1195 ochoa HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:38225354}.
Q9H7U1 CCSER2 S133 ochoa Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}.
Q9HAS0 C17orf75 S24 ochoa Protein Njmu-R1 As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. {ECO:0000269|PubMed:29426865}.
Q9HBR0 SLC38A10 S685 ochoa Solute carrier family 38 member 10 (Amino acid transporter SLC38A10) Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q5I012}.
Q9NPL8 TIMMDC1 S253 ochoa Complex I assembly factor TIMMDC1, mitochondrial (Protein M5-14) (Translocase of inner mitochondrial membrane domain-containing protein 1) (TIMM domain containing-protein 1) Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I. {ECO:0000269|PubMed:24191001}.
Q9NQ86 TRIM36 S462 ochoa E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}.
Q9NR09 BIRC6 S3951 ochoa Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}.
Q9NR30 DDX21 S567 ochoa Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}.
Q9NRA8 EIF4ENIF1 S78 ochoa Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}.
Q9NU22 MDN1 S4538 ochoa Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein) Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). {ECO:0000250|UniProtKB:Q12019, ECO:0000269|PubMed:27814492}.
Q9NUY8 TBC1D23 S507 ochoa TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}.
Q9NVA2 SEPTIN11 S318 ochoa Septin-11 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:19234302, ECO:0000305}.
Q9NVT9 ARMC1 S260 ochoa Armadillo repeat-containing protein 1 In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. {ECO:0000269|PubMed:31644573}.
Q9NWV8 BABAM1 S47 ochoa BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.
Q9NZB2 FAM120A S396 ochoa Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}.
Q9NZZ3 CHMP5 S26 ochoa Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60) Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) (PubMed:14519844). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release (PubMed:14519844). {ECO:0000269|PubMed:14519844}.
Q9P242 NYAP2 S206 ochoa Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}.
Q9P272 TRMT9B S255 ochoa Probable tRNA methyltransferase 9B (Probable tRNA methyltransferase 9-like protein) (EC 2.1.1.-) May modify wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9. {ECO:0000269|PubMed:23381944}.
Q9P2F8 SIPA1L2 S300 ochoa Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) None
Q9UBT2 UBA2 S289 ochoa SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}.
Q9UBT7 CTNNAL1 S374 ochoa Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
Q9UJY4 GGA2 S233 ochoa ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}.
Q9UK61 TASOR S658 ochoa Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}.
Q9UKG1 APPL1 S491 ochoa DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}.
Q9ULV4 CORO1C S309 ochoa Coronin-1C (Coronin-3) (hCRNN4) Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}.
Q9ULW0 TPX2 S646 ochoa Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.
Q9UNS1 TIMELESS S1121 ochoa Protein timeless homolog (hTIM) Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}.
Q9UPV0 CEP164 S455 ochoa Centrosomal protein of 164 kDa (Cep164) Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}.
Q9UQR1 ZNF148 S690 ochoa Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Q9Y266 NUDC S260 ochoa Nuclear migration protein nudC (Nuclear distribution protein C homolog) Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}.
Q9Y266 NUDC S285 ochoa Nuclear migration protein nudC (Nuclear distribution protein C homolog) Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}.
Q9Y281 CFL2 S24 ochoa Cofilin-2 (Cofilin, muscle isoform) Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). {ECO:0000250|UniProtKB:P45591, ECO:0000269|PubMed:19752190}.
Q9Y2W7 KCNIP3 S63 psp Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3) Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). {ECO:0000250|UniProtKB:Q9QXT8}.; FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. {ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:16123112, ECO:0000269|PubMed:18957440}.; FUNCTION: May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. {ECO:0000269|PubMed:11259376, ECO:0000269|PubMed:11988022, ECO:0000269|PubMed:9771752}.
Q9Y4E5 ZNF451 S838 ochoa E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7, ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267, ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}.
Q9Y4E8 USP15 S678 psp Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4) Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24852371). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). {ECO:0000269|PubMed:16005295, ECO:0000269|PubMed:17318178, ECO:0000269|PubMed:19576224, ECO:0000269|PubMed:19826004, ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:22344298, ECO:0000269|PubMed:24526689, ECO:0000269|PubMed:24852371, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:33093067}.; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. {ECO:0000269|PubMed:19553310}.
Q9Y4F1 FARP1 S23 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
Q9Y6I3 EPN1 S220 ochoa Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}.
Q9Y2B0 CNPY2 S65 Sugiyama Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
O43423 ANP32CP S100 Sugiyama Putative uncharacterized protein ANP32CP (Acidic leucine-rich nuclear phosphoprotein 32 family member C) (Phosphoprotein 32-related protein 1) (Tumorigenic protein pp32r1) None
O95626 ANP32D S104 Sugiyama Acidic leucine-rich nuclear phosphoprotein 32 family member D (Phosphoprotein 32-related protein 2) (Tumorigenic protein pp32r2) None
P39687 ANP32A S104 Sugiyama Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}.
Q8IZ69 TRMT2A S480 Sugiyama tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-) S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331). Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281). {ECO:0000269|PubMed:31361898, ECO:0000269|PubMed:33799331, ECO:0000269|PubMed:34123281, ECO:0000269|PubMed:34556860}.
Q92688 ANP32B S104 Sugiyama Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}.
P23396 RPS3 S35 Sugiyama Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}.
P55036 PSMD4 S115 Sugiyama 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}.
O60285 NUAK1 S266 Sugiyama NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}.
Q99584 S100A13 S34 Sugiyama Protein S100-A13 (S100 calcium-binding protein A13) Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). {ECO:0000250|UniProtKB:P97352, ECO:0000269|PubMed:12746488, ECO:0000269|PubMed:20863990}.
Q99798 ACO2 S388 Sugiyama Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}.
Q92890 UFD1 Y219 Sugiyama Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES53, ECO:0000269|PubMed:26471729}.
P35573 AGL S1282 Sugiyama Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
P52789 HK2 S340 Sugiyama Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}.
Q9UBS4 DNAJB11 S78 Sugiyama DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4) As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351). {ECO:0000269|PubMed:10827079, ECO:0000269|PubMed:15525676, ECO:0000269|PubMed:29706351}.
Q9UNN4 GTF2A1L S357 SIGNOR|ELM|iPTMNet TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor) May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. {ECO:0000269|PubMed:10364255}.
P08174 CD55 Y133 Sugiyama Complement decay-accelerating factor (CD antigen CD55) This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}.
Q02750 MAP2K1 S24 ELM Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}.
O75116 ROCK2 S724 Sugiyama Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}.
P42681 TXK S305 Sugiyama Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase) Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Also contributes to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976). Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976). Also phosphorylates key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. {ECO:0000269|PubMed:10523612, ECO:0000269|PubMed:11564877, ECO:0000269|PubMed:11859127, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:9813138}.
Q96P16 RPRD1A S109 Sugiyama Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein) Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.
Q6UVJ0 SASS6 S283 Sugiyama Spindle assembly abnormal protein 6 homolog (HsSAS-6) (Spindle assembly defective protein 6) Central scaffolding component of the centrioles ensuring their 9-fold symmetry (By similarity). Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:15665853, PubMed:16244668, PubMed:17681131). Not required for centriole formation in embryonic stem cells but necessary to maintain centriole architecture (By similarity). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). Overexpression results in excess foci-bearing centriolar markers (PubMed:15665853). {ECO:0000250|UniProtKB:Q7ZVT3, ECO:0000250|UniProtKB:Q80UK7, ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:22020124}.
Q14980 NUMA1 S861 Sugiyama Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
P51955 NEK2 S43 Sugiyama Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.
Q99426 TBCB Y133 Sugiyama Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}.
Q6XUX3 DSTYK Y486 Sugiyama Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}.
P05423 POLR3D S250 Sugiyama DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog) DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3E/RPC5 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:P25441, ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:34675218, ECO:0000269|PubMed:35637192}.
Q14980 NUMA1 S1162 Sugiyama Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Q9BTD8 RBM42 S372 Sugiyama RNA-binding protein 42 (RNA-binding motif protein 42) Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. {ECO:0000250}.
Q14289 PTK2B S967 Sugiyama Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}.
P50542 PEX5 S279 Sugiyama Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:11101887, PubMed:11336669, PubMed:12456682, PubMed:16314507, PubMed:17157249, PubMed:17428317, PubMed:21976670, PubMed:26344566, PubMed:7706321, PubMed:7719337, PubMed:7790377). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:12456682, PubMed:17157249, PubMed:21976670, PubMed:26344566). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:11336669, PubMed:24662292). {ECO:0000269|PubMed:11101887, ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:12456682, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:17157249, ECO:0000269|PubMed:17428317, ECO:0000269|PubMed:21976670, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:7706321, ECO:0000269|PubMed:7719337, ECO:0000269|PubMed:7790377}.; FUNCTION: [Isoform 1]: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed:11336669, PubMed:11546814, PubMed:25538232, PubMed:33389129, PubMed:9668159). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (PubMed:25538232). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 (PubMed:25538232). {ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:25538232, ECO:0000269|PubMed:33389129, ECO:0000269|PubMed:9668159}.; FUNCTION: [Isoform 2]: Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. {ECO:0000269|PubMed:11546814}.
Q13464 ROCK1 S576 Sugiyama Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}.
Q8TBC4 UBA3 S420 Sugiyama NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}.
Q9Y6D9 MAD1L1 S485 Sugiyama Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}.
Q9GZM8 NDEL1 S95 PSP Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}.
Q9NQP4 PFDN4 S103 Sugiyama Prefoldin subunit 4 (Protein C-1) Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.
Q5VT25 CDC42BPA S507 Sugiyama Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.
Q6PHR2 ULK3 S339 Sugiyama Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}.
Q8WYL5 SSH1 S441 Sugiyama Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}.
Q8WUM4 PDCD6IP S632 Sugiyama Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}.
Q15382 RHEB S149 Sugiyama GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:12906785, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:22819219, PubMed:24529379, PubMed:29416044, PubMed:32470140, PubMed:33157014, PubMed:25816988). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:29236692, PubMed:33157014). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059). {ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0000269|PubMed:33157014}.
P50851 LRBA S993 Sugiyama Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}.
O94992 HEXIM1 S299 Sugiyama Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}.
Q9UK32 RPS6KA6 S394 Sugiyama Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}.
Q13435 SF3B2 S171 Sugiyama Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}.
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reactome_id name p -log10_p
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 5.816680e-12 11.235
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 1.172895e-11 10.931
R-HSA-73728 RNA Polymerase I Promoter Opening 2.489942e-11 10.604
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 2.632161e-11 10.580
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 1.323059e-10 9.878
R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus 1.550167e-10 9.810
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 2.870105e-10 9.542
R-HSA-5693606 DNA Double Strand Break Response 3.172295e-10 9.499
R-HSA-171306 Packaging Of Telomere Ends 4.166181e-10 9.380
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 5.894328e-10 9.230
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 7.130662e-10 9.147
R-HSA-5334118 DNA methylation 7.647704e-10 9.116
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 1.780144e-09 8.750
R-HSA-68616 Assembly of the ORC complex at the origin of replication 2.322196e-09 8.634
R-HSA-5693607 Processing of DNA double-strand break ends 3.117216e-09 8.506
R-HSA-9018519 Estrogen-dependent gene expression 3.586484e-09 8.445
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 3.868286e-09 8.412
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 4.915702e-09 8.308
R-HSA-774815 Nucleosome assembly 4.915702e-09 8.308
R-HSA-212300 PRC2 methylates histones and DNA 6.277123e-09 8.202
R-HSA-2299718 Condensation of Prophase Chromosomes 6.030037e-09 8.220
R-HSA-427359 SIRT1 negatively regulates rRNA expression 7.923994e-09 8.101
R-HSA-110331 Cleavage of the damaged purine 7.923994e-09 8.101
R-HSA-69473 G2/M DNA damage checkpoint 8.922345e-09 8.050
R-HSA-73927 Depurination 9.946270e-09 8.002
R-HSA-9670095 Inhibition of DNA recombination at telomere 1.542118e-08 7.812
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 1.542118e-08 7.812
R-HSA-912446 Meiotic recombination 1.579169e-08 7.802
R-HSA-73772 RNA Polymerase I Promoter Escape 1.893841e-08 7.723
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 1.905703e-08 7.720
R-HSA-1221632 Meiotic synapsis 2.263660e-08 7.645
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 2.263660e-08 7.645
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 2.965646e-08 7.528
R-HSA-110329 Cleavage of the damaged pyrimidine 2.869430e-08 7.542
R-HSA-73928 Depyrimidination 2.869430e-08 7.542
R-HSA-3214815 HDACs deacetylate histones 3.203256e-08 7.494
R-HSA-9710421 Defective pyroptosis 3.497524e-08 7.456
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 4.600158e-08 7.337
R-HSA-5578749 Transcriptional regulation by small RNAs 5.332197e-08 7.273
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 7.248604e-08 7.140
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 7.248604e-08 7.140
R-HSA-5693538 Homology Directed Repair 8.580018e-08 7.067
R-HSA-9616222 Transcriptional regulation of granulopoiesis 9.862479e-08 7.006
R-HSA-5693532 DNA Double-Strand Break Repair 1.074123e-07 6.969
R-HSA-69620 Cell Cycle Checkpoints 1.380475e-07 6.860
R-HSA-9816359 Maternal to zygotic transition (MZT) 1.406245e-07 6.852
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 1.747687e-07 6.758
R-HSA-977225 Amyloid fiber formation 1.780444e-07 6.749
R-HSA-68886 M Phase 2.102051e-07 6.677
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 2.017978e-07 6.695
R-HSA-69481 G2/M Checkpoints 2.256215e-07 6.647
R-HSA-73929 Base-Excision Repair, AP Site Formation 2.409098e-07 6.618
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 2.579993e-07 6.588
R-HSA-1500620 Meiosis 2.910467e-07 6.536
R-HSA-9764560 Regulation of CDH1 Gene Transcription 3.080523e-07 6.511
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 3.518461e-07 6.454
R-HSA-427413 NoRC negatively regulates rRNA expression 3.518461e-07 6.454
R-HSA-9645723 Diseases of programmed cell death 4.644654e-07 6.333
R-HSA-9909648 Regulation of PD-L1(CD274) expression 5.251028e-07 6.280
R-HSA-68875 Mitotic Prophase 5.835948e-07 6.234
R-HSA-73854 RNA Polymerase I Promoter Clearance 6.650946e-07 6.177
R-HSA-73864 RNA Polymerase I Transcription 8.476192e-07 6.072
R-HSA-68867 Assembly of the pre-replicative complex 8.988337e-07 6.046
R-HSA-2559583 Cellular Senescence 9.350438e-07 6.029
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 1.073253e-06 5.969
R-HSA-3214847 HATs acetylate histones 1.837039e-06 5.736
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 2.191269e-06 5.659
R-HSA-8939211 ESR-mediated signaling 2.277768e-06 5.642
R-HSA-9842860 Regulation of endogenous retroelements 2.454677e-06 5.610
R-HSA-5619507 Activation of HOX genes during differentiation 3.250095e-06 5.488
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 3.250095e-06 5.488
R-HSA-389948 Co-inhibition by PD-1 3.500447e-06 5.456
R-HSA-1912408 Pre-NOTCH Transcription and Translation 3.918544e-06 5.407
R-HSA-8852135 Protein ubiquitination 3.930756e-06 5.406
R-HSA-1640170 Cell Cycle 4.499700e-06 5.347
R-HSA-211000 Gene Silencing by RNA 4.266057e-06 5.370
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 4.982054e-06 5.303
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 4.982054e-06 5.303
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 4.982054e-06 5.303
R-HSA-69002 DNA Replication Pre-Initiation 5.090718e-06 5.293
R-HSA-157579 Telomere Maintenance 8.415678e-06 5.075
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 1.150765e-05 4.939
R-HSA-69278 Cell Cycle, Mitotic 1.307854e-05 4.883
R-HSA-4839726 Chromatin organization 1.557541e-05 4.808
R-HSA-73886 Chromosome Maintenance 1.597953e-05 4.796
R-HSA-73884 Base Excision Repair 1.990959e-05 4.701
R-HSA-388841 Regulation of T cell activation by CD28 family 2.203208e-05 4.657
R-HSA-3247509 Chromatin modifying enzymes 2.492065e-05 4.603
R-HSA-1500931 Cell-Cell communication 3.331962e-05 4.477
R-HSA-1912422 Pre-NOTCH Expression and Processing 3.469270e-05 4.460
R-HSA-1474165 Reproduction 3.552864e-05 4.449
R-HSA-9764265 Regulation of CDH1 Expression and Function 4.012602e-05 4.397
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 4.012602e-05 4.397
R-HSA-69306 DNA Replication 4.407762e-05 4.356
R-HSA-446728 Cell junction organization 6.069193e-05 4.217
R-HSA-2559580 Oxidative Stress Induced Senescence 6.468811e-05 4.189
R-HSA-201681 TCF dependent signaling in response to WNT 7.033832e-05 4.153
R-HSA-199992 trans-Golgi Network Vesicle Budding 1.022553e-04 3.990
R-HSA-418990 Adherens junctions interactions 1.269751e-04 3.896
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 1.382013e-04 3.859
R-HSA-5689880 Ub-specific processing proteases 1.466960e-04 3.834
R-HSA-421270 Cell-cell junction organization 1.773848e-04 3.751
R-HSA-140342 Apoptosis induced DNA fragmentation 2.374610e-04 3.624
R-HSA-2132295 MHC class II antigen presentation 3.353763e-04 3.474
R-HSA-157118 Signaling by NOTCH 3.362213e-04 3.473
R-HSA-212165 Epigenetic regulation of gene expression 3.546893e-04 3.450
R-HSA-73894 DNA Repair 4.742295e-04 3.324
R-HSA-9006931 Signaling by Nuclear Receptors 5.224500e-04 3.282
R-HSA-432722 Golgi Associated Vesicle Biogenesis 5.313715e-04 3.275
R-HSA-8878171 Transcriptional regulation by RUNX1 5.610613e-04 3.251
R-HSA-8953897 Cellular responses to stimuli 5.754932e-04 3.240
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 6.472144e-04 3.189
R-HSA-199991 Membrane Trafficking 6.758062e-04 3.170
R-HSA-9610379 HCMV Late Events 7.312502e-04 3.136
R-HSA-195721 Signaling by WNT 1.048125e-03 2.980
R-HSA-1280218 Adaptive Immune System 1.165073e-03 2.934
R-HSA-9609690 HCMV Early Events 1.383008e-03 2.859
R-HSA-75153 Apoptotic execution phase 1.548020e-03 2.810
R-HSA-5688426 Deubiquitination 1.675151e-03 2.776
R-HSA-196025 Formation of annular gap junctions 2.081718e-03 2.682
R-HSA-162582 Signal Transduction 2.161871e-03 2.665
R-HSA-190873 Gap junction degradation 2.658380e-03 2.575
R-HSA-109581 Apoptosis 2.908280e-03 2.536
R-HSA-163765 ChREBP activates metabolic gene expression 4.084517e-03 2.389
R-HSA-2262752 Cellular responses to stress 4.148401e-03 2.382
R-HSA-983189 Kinesins 4.764219e-03 2.322
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 5.512498e-03 2.259
R-HSA-5357801 Programmed Cell Death 5.586377e-03 2.253
R-HSA-8854518 AURKA Activation by TPX2 7.085115e-03 2.150
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 6.949840e-03 2.158
R-HSA-5653656 Vesicle-mediated transport 7.681382e-03 2.115
R-HSA-9609646 HCMV Infection 9.045927e-03 2.044
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 9.344380e-03 2.029
R-HSA-68877 Mitotic Prometaphase 9.437511e-03 2.025
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1.113139e-02 1.953
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 1.229039e-02 1.910
R-HSA-416482 G alpha (12/13) signalling events 1.400883e-02 1.854
R-HSA-427975 Proton/oligopeptide cotransporters 1.432682e-02 1.844
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 1.442013e-02 1.841
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 1.550382e-02 1.810
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 1.562873e-02 1.806
R-HSA-9860931 Response of endothelial cells to shear stress 1.632337e-02 1.787
R-HSA-432720 Lysosome Vesicle Biogenesis 1.685579e-02 1.773
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.881834e-02 1.725
R-HSA-9669937 Drug resistance of KIT mutants 2.223017e-02 1.653
R-HSA-9669921 KIT mutants bind TKIs 2.223017e-02 1.653
R-HSA-9669924 Masitinib-resistant KIT mutants 2.223017e-02 1.653
R-HSA-9669936 Sorafenib-resistant KIT mutants 2.223017e-02 1.653
R-HSA-9669914 Dasatinib-resistant KIT mutants 2.223017e-02 1.653
R-HSA-9669934 Sunitinib-resistant KIT mutants 2.223017e-02 1.653
R-HSA-9669929 Regorafenib-resistant KIT mutants 2.223017e-02 1.653
R-HSA-9669917 Imatinib-resistant KIT mutants 2.223017e-02 1.653
R-HSA-9669926 Nilotinib-resistant KIT mutants 2.223017e-02 1.653
R-HSA-2470946 Cohesin Loading onto Chromatin 2.173897e-02 1.663
R-HSA-139915 Activation of PUMA and translocation to mitochondria 2.173897e-02 1.663
R-HSA-9959399 SLC-mediated transport of oligopeptides 2.173897e-02 1.663
R-HSA-8964043 Plasma lipoprotein clearance 2.096606e-02 1.678
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 2.317726e-02 1.635
R-HSA-380259 Loss of Nlp from mitotic centrosomes 2.317726e-02 1.635
R-HSA-2467813 Separation of Sister Chromatids 2.349222e-02 1.629
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 2.360301e-02 1.627
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 2.401906e-02 1.619
R-HSA-9855142 Cellular responses to mechanical stimuli 2.523520e-02 1.598
R-HSA-444257 RSK activation 2.592251e-02 1.586
R-HSA-9669938 Signaling by KIT in disease 2.599829e-02 1.585
R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... 2.599829e-02 1.585
R-HSA-8964038 LDL clearance 2.599829e-02 1.585
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 2.732768e-02 1.563
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 2.818204e-02 1.550
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 2.842082e-02 1.546
R-HSA-2682334 EPH-Ephrin signaling 2.914245e-02 1.535
R-HSA-9700645 ALK mutants bind TKIs 3.040319e-02 1.517
R-HSA-390450 Folding of actin by CCT/TriC 3.516580e-02 1.454
R-HSA-9664873 Pexophagy 3.516580e-02 1.454
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 3.516580e-02 1.454
R-HSA-9020956 Interleukin-27 signaling 3.516580e-02 1.454
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 3.276557e-02 1.485
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 2.993849e-02 1.524
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 3.089541e-02 1.510
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 3.547505e-02 1.450
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 3.637980e-02 1.439
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 3.673818e-02 1.435
R-HSA-168255 Influenza Infection 3.705962e-02 1.431
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 3.753017e-02 1.426
R-HSA-264876 Insulin processing 3.926078e-02 1.406
R-HSA-9706019 RHOBTB3 ATPase cycle 4.019568e-02 1.396
R-HSA-380287 Centrosome maturation 4.093043e-02 1.388
R-HSA-1169408 ISG15 antiviral mechanism 4.093043e-02 1.388
R-HSA-69618 Mitotic Spindle Checkpoint 4.113327e-02 1.386
R-HSA-5602566 TICAM1 deficiency - HSE 4.396749e-02 1.357
R-HSA-373756 SDK interactions 4.396749e-02 1.357
R-HSA-69275 G2/M Transition 4.440657e-02 1.353
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 4.547864e-02 1.342
R-HSA-5693548 Sensing of DNA Double Strand Breaks 4.547864e-02 1.342
R-HSA-68884 Mitotic Telophase/Cytokinesis 4.547864e-02 1.342
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 4.547864e-02 1.342
R-HSA-453274 Mitotic G2-G2/M phases 4.667276e-02 1.331
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 5.100103e-02 1.292
R-HSA-8984722 Interleukin-35 Signalling 5.100103e-02 1.292
R-HSA-8866427 VLDLR internalisation and degradation 5.100103e-02 1.292
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 5.189642e-02 1.285
R-HSA-182971 EGFR downregulation 5.189642e-02 1.285
R-HSA-9680187 Signaling by extracellular domain mutants of KIT 6.522286e-02 1.186
R-HSA-9669935 Signaling by juxtamembrane domain KIT mutants 6.522286e-02 1.186
R-HSA-9669933 Signaling by kinase domain mutants of KIT 6.522286e-02 1.186
R-HSA-5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... 6.522286e-02 1.186
R-HSA-5602571 TRAF3 deficiency - HSE 6.522286e-02 1.186
R-HSA-177504 Retrograde neurotrophin signalling 6.271177e-02 1.203
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 6.250175e-02 1.204
R-HSA-141424 Amplification of signal from the kinetochores 6.288360e-02 1.201
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 6.288360e-02 1.201
R-HSA-1059683 Interleukin-6 signaling 5.674964e-02 1.246
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 6.271177e-02 1.203
R-HSA-1839124 FGFR1 mutant receptor activation 5.886228e-02 1.230
R-HSA-9012852 Signaling by NOTCH3 5.521904e-02 1.258
R-HSA-9705683 SARS-CoV-2-host interactions 5.632517e-02 1.249
R-HSA-193648 NRAGE signals death through JNK 5.782421e-02 1.238
R-HSA-422475 Axon guidance 5.611599e-02 1.251
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 5.674964e-02 1.246
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 5.674964e-02 1.246
R-HSA-438064 Post NMDA receptor activation events 6.746799e-02 1.171
R-HSA-196780 Biotin transport and metabolism 6.887512e-02 1.162
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 7.008500e-02 1.154
R-HSA-4420097 VEGFA-VEGFR2 Pathway 7.337503e-02 1.134
R-HSA-111933 Calmodulin induced events 7.402505e-02 1.131
R-HSA-111997 CaM pathway 7.402505e-02 1.131
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 7.437914e-02 1.129
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 7.468362e-02 1.127
R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis 7.522787e-02 1.124
R-HSA-5099900 WNT5A-dependent internalization of FZD4 7.522787e-02 1.124
R-HSA-373760 L1CAM interactions 7.549584e-02 1.122
R-HSA-70326 Glucose metabolism 7.765123e-02 1.110
R-HSA-6790901 rRNA modification in the nucleus and cytosol 7.785039e-02 1.109
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 7.785039e-02 1.109
R-HSA-381070 IRE1alpha activates chaperones 7.971806e-02 1.098
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 8.600694e-02 1.065
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 8.600694e-02 1.065
R-HSA-198765 Signalling to ERK5 8.600694e-02 1.065
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 8.600694e-02 1.065
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 8.600694e-02 1.065
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 8.600694e-02 1.065
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 8.600694e-02 1.065
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 8.600694e-02 1.065
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 8.600694e-02 1.065
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 8.600694e-02 1.065
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 8.600694e-02 1.065
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 8.600694e-02 1.065
R-HSA-5682113 Defective ABCA1 causes TGD 1.063302e-01 0.973
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 1.063302e-01 0.973
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 1.063302e-01 0.973
R-HSA-163615 PKA activation 9.531040e-02 1.021
R-HSA-164378 PKA activation in glucagon signalling 9.531040e-02 1.021
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 8.175860e-02 1.087
R-HSA-391251 Protein folding 8.230184e-02 1.085
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 8.661680e-02 1.062
R-HSA-8868773 rRNA processing in the nucleus and cytosol 9.840078e-02 1.007
R-HSA-3249367 STAT6-mediated induction of chemokines 1.063302e-01 0.973
R-HSA-165159 MTOR signalling 1.041869e-01 0.982
R-HSA-9613829 Chaperone Mediated Autophagy 9.531040e-02 1.021
R-HSA-68882 Mitotic Anaphase 8.832052e-02 1.054
R-HSA-2555396 Mitotic Metaphase and Anaphase 9.005654e-02 1.045
R-HSA-168276 NS1 Mediated Effects on Host Pathways 8.641516e-02 1.063
R-HSA-5655302 Signaling by FGFR1 in disease 9.961636e-02 1.002
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 1.043977e-01 0.981
R-HSA-111996 Ca-dependent events 1.041869e-01 0.982
R-HSA-3214841 PKMTs methylate histone lysines 9.512943e-02 1.022
R-HSA-194138 Signaling by VEGF 9.858847e-02 1.006
R-HSA-5210891 Uptake and function of anthrax toxins 8.845631e-02 1.053
R-HSA-9675108 Nervous system development 9.019124e-02 1.045
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 8.305167e-02 1.081
R-HSA-9824446 Viral Infection Pathways 8.919249e-02 1.050
R-HSA-70171 Glycolysis 1.075020e-01 0.969
R-HSA-9924644 Developmental Lineages of the Mammary Gland 1.079740e-01 0.967
R-HSA-1433557 Signaling by SCF-KIT 1.088387e-01 0.963
R-HSA-8854214 TBC/RABGAPs 1.088387e-01 0.963
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 1.094472e-01 0.961
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 1.094472e-01 0.961
R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death 1.262027e-01 0.899
R-HSA-165181 Inhibition of TSC complex formation by PKB 1.262027e-01 0.899
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 1.262027e-01 0.899
R-HSA-9652169 Signaling by MAP2K mutants 1.262027e-01 0.899
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 1.456345e-01 0.837
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 1.456345e-01 0.837
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 1.646354e-01 0.783
R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels 1.646354e-01 0.783
R-HSA-8964011 HDL clearance 1.832148e-01 0.737
R-HSA-8951430 RUNX3 regulates WNT signaling 2.013821e-01 0.696
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 2.013821e-01 0.696
R-HSA-2562578 TRIF-mediated programmed cell death 2.013821e-01 0.696
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 2.191464e-01 0.659
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 2.365167e-01 0.626
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ 2.365167e-01 0.626
R-HSA-9613354 Lipophagy 2.365167e-01 0.626
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 1.167106e-01 0.933
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 2.535015e-01 0.596
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 2.535015e-01 0.596
R-HSA-110056 MAPK3 (ERK1) activation 2.535015e-01 0.596
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 2.701096e-01 0.568
R-HSA-429947 Deadenylation of mRNA 1.468552e-01 0.833
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 1.468552e-01 0.833
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 2.863491e-01 0.543
R-HSA-202670 ERKs are inactivated 2.863491e-01 0.543
R-HSA-5339716 Signaling by GSK3beta mutants 2.863491e-01 0.543
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 3.022283e-01 0.520
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 3.022283e-01 0.520
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 3.022283e-01 0.520
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 3.022283e-01 0.520
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 3.022283e-01 0.520
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 3.022283e-01 0.520
R-HSA-445095 Interaction between L1 and Ankyrins 1.703812e-01 0.769
R-HSA-170660 Adenylate cyclase activating pathway 3.177552e-01 0.498
R-HSA-9615710 Late endosomal microautophagy 1.863912e-01 0.730
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 1.944740e-01 0.711
R-HSA-1433559 Regulation of KIT signaling 3.329374e-01 0.478
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.026004e-01 0.693
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.026004e-01 0.693
R-HSA-1855170 IPs transport between nucleus and cytosol 2.189604e-01 0.660
R-HSA-159227 Transport of the SLBP independent Mature mRNA 2.189604e-01 0.660
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.271830e-01 0.644
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 1.593240e-01 0.798
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 1.701657e-01 0.769
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 2.436871e-01 0.613
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1.756646e-01 0.755
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 2.767986e-01 0.558
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 2.850726e-01 0.545
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 2.270915e-01 0.644
R-HSA-5674135 MAP2K and MAPK activation 3.015888e-01 0.521
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 1.369601e-01 0.863
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 2.748607e-01 0.561
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 2.851354e-01 0.545
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 3.296267e-01 0.482
R-HSA-72163 mRNA Splicing - Major Pathway 2.064323e-01 0.685
R-HSA-72172 mRNA Splicing 2.420374e-01 0.616
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 3.177552e-01 0.498
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 2.338988e-01 0.631
R-HSA-9948299 Ribosome-associated quality control 2.711487e-01 0.567
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 2.863491e-01 0.543
R-HSA-3295583 TRP channels 1.624670e-01 0.789
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 1.232594e-01 0.909
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 1.232594e-01 0.909
R-HSA-9649948 Signaling downstream of RAS mutants 1.232594e-01 0.909
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 2.172871e-01 0.663
R-HSA-390466 Chaperonin-mediated protein folding 1.719852e-01 0.765
R-HSA-927802 Nonsense-Mediated Decay (NMD) 3.051110e-01 0.516
R-HSA-9762292 Regulation of CDH11 function 2.535015e-01 0.596
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 3.051110e-01 0.516
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 2.602375e-01 0.585
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 2.423933e-01 0.615
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 2.627977e-01 0.580
R-HSA-453276 Regulation of mitotic cell cycle 2.627977e-01 0.580
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 2.354269e-01 0.628
R-HSA-6802957 Oncogenic MAPK signaling 1.590995e-01 0.798
R-HSA-8941856 RUNX3 regulates NOTCH signaling 3.022283e-01 0.520
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 2.189604e-01 0.660
R-HSA-9656223 Signaling by RAF1 mutants 3.015888e-01 0.521
R-HSA-5693537 Resolution of D-Loop Structures 2.271830e-01 0.644
R-HSA-8856828 Clathrin-mediated endocytosis 2.968917e-01 0.527
R-HSA-165158 Activation of AKT2 1.456345e-01 0.837
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 1.646354e-01 0.783
R-HSA-204626 Hypusine synthesis from eIF5A-lysine 2.365167e-01 0.626
R-HSA-8963901 Chylomicron remodeling 3.177552e-01 0.498
R-HSA-6802949 Signaling by RAS mutants 1.232594e-01 0.909
R-HSA-8963896 HDL assembly 3.329374e-01 0.478
R-HSA-354192 Integrin signaling 2.189604e-01 0.660
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 2.189604e-01 0.660
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 2.602375e-01 0.585
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 2.851354e-01 0.545
R-HSA-9703465 Signaling by FLT3 fusion proteins 1.624670e-01 0.789
R-HSA-8963888 Chylomicron assembly 2.701096e-01 0.568
R-HSA-111931 PKA-mediated phosphorylation of CREB 1.167106e-01 0.933
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 2.863491e-01 0.543
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 2.271830e-01 0.644
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 2.271830e-01 0.644
R-HSA-9663891 Selective autophagy 1.763592e-01 0.754
R-HSA-381119 Unfolded Protein Response (UPR) 1.423369e-01 0.847
R-HSA-69478 G2/M DNA replication checkpoint 1.832148e-01 0.737
R-HSA-446107 Type I hemidesmosome assembly 2.191464e-01 0.659
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 2.863491e-01 0.543
R-HSA-877312 Regulation of IFNG signaling 3.022283e-01 0.520
R-HSA-437239 Recycling pathway of L1 1.282137e-01 0.892
R-HSA-162588 Budding and maturation of HIV virion 2.026004e-01 0.693
R-HSA-163359 Glucagon signaling in metabolic regulation 2.271830e-01 0.644
R-HSA-180910 Vpr-mediated nuclear import of PICs 2.602375e-01 0.585
R-HSA-6807878 COPI-mediated anterograde transport 2.219880e-01 0.654
R-HSA-8951664 Neddylation 3.004020e-01 0.522
R-HSA-8985947 Interleukin-9 signaling 2.191464e-01 0.659
R-HSA-72312 rRNA processing 1.184885e-01 0.926
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 3.022283e-01 0.520
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 2.191464e-01 0.659
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 1.944740e-01 0.711
R-HSA-1227990 Signaling by ERBB2 in Cancer 1.944740e-01 0.711
R-HSA-9793380 Formation of paraxial mesoderm 2.038488e-01 0.691
R-HSA-9020958 Interleukin-21 signaling 2.365167e-01 0.626
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 3.329374e-01 0.478
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.271830e-01 0.644
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 2.354269e-01 0.628
R-HSA-69541 Stabilization of p53 2.767986e-01 0.558
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 1.393729e-01 0.856
R-HSA-3000480 Scavenging by Class A Receptors 3.015888e-01 0.521
R-HSA-9612973 Autophagy 2.002991e-01 0.698
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 1.987718e-01 0.702
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 2.365167e-01 0.626
R-HSA-166208 mTORC1-mediated signalling 1.315818e-01 0.881
R-HSA-112040 G-protein mediated events 2.388976e-01 0.622
R-HSA-5602358 Diseases associated with the TLR signaling cascade 2.850726e-01 0.545
R-HSA-5260271 Diseases of Immune System 2.850726e-01 0.545
R-HSA-1632852 Macroautophagy 1.483524e-01 0.829
R-HSA-5674499 Negative feedback regulation of MAPK pathway 1.646354e-01 0.783
R-HSA-8964046 VLDL clearance 2.013821e-01 0.696
R-HSA-112313 Neurotransmitter uptake and metabolism In glial cells 2.191464e-01 0.659
R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 2.191464e-01 0.659
R-HSA-9768777 Regulation of NPAS4 gene transcription 2.365167e-01 0.626
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 2.365167e-01 0.626
R-HSA-1483226 Synthesis of PI 2.701096e-01 0.568
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 3.177552e-01 0.498
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 1.183773e-01 0.927
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 1.197837e-01 0.922
R-HSA-400685 Sema4D in semaphorin signaling 1.546226e-01 0.811
R-HSA-170968 Frs2-mediated activation 3.177552e-01 0.498
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 2.436871e-01 0.613
R-HSA-5578775 Ion homeostasis 1.756646e-01 0.755
R-HSA-9818749 Regulation of NFE2L2 gene expression 1.832148e-01 0.737
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 2.365167e-01 0.626
R-HSA-351200 Interconversion of polyamines 3.177552e-01 0.498
R-HSA-180746 Nuclear import of Rev protein 2.354269e-01 0.628
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 2.767986e-01 0.558
R-HSA-445717 Aquaporin-mediated transport 2.038488e-01 0.691
R-HSA-69615 G1/S DNA Damage Checkpoints 2.154030e-01 0.667
R-HSA-8953854 Metabolism of RNA 2.182663e-01 0.661
R-HSA-5218920 VEGFR2 mediated vascular permeability 2.933372e-01 0.533
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 2.013821e-01 0.696
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 2.013821e-01 0.696
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 2.191464e-01 0.659
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 2.365167e-01 0.626
R-HSA-425381 Bicarbonate transporters 2.701096e-01 0.568
R-HSA-3928663 EPHA-mediated growth cone collapse 1.703812e-01 0.769
R-HSA-9796292 Formation of axial mesoderm 3.177552e-01 0.498
R-HSA-177243 Interactions of Rev with host cellular proteins 2.850726e-01 0.545
R-HSA-176033 Interactions of Vpr with host cellular proteins 2.850726e-01 0.545
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 2.933372e-01 0.533
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 2.851354e-01 0.545
R-HSA-983169 Class I MHC mediated antigen processing & presentation 3.023720e-01 0.519
R-HSA-3214842 HDMs demethylate histones 1.546226e-01 0.811
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 1.624670e-01 0.789
R-HSA-8853884 Transcriptional Regulation by VENTX 2.933372e-01 0.533
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 2.933372e-01 0.533
R-HSA-177929 Signaling by EGFR 1.756646e-01 0.755
R-HSA-1489509 DAG and IP3 signaling 1.183773e-01 0.927
R-HSA-8863795 Downregulation of ERBB2 signaling 1.944740e-01 0.711
R-HSA-9682385 FLT3 signaling in disease 2.519588e-01 0.599
R-HSA-447115 Interleukin-12 family signaling 1.719852e-01 0.765
R-HSA-9764302 Regulation of CDH19 Expression and Function 1.646354e-01 0.783
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 2.191464e-01 0.659
R-HSA-912694 Regulation of IFNA/IFNB signaling 1.315818e-01 0.881
R-HSA-427601 Inorganic anion exchange by SLC26 transporters 2.701096e-01 0.568
R-HSA-200425 Carnitine shuttle 1.391724e-01 0.856
R-HSA-190828 Gap junction trafficking 1.135696e-01 0.945
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 3.329374e-01 0.478
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 2.685189e-01 0.571
R-HSA-74160 Gene expression (Transcription) 3.236636e-01 0.490
R-HSA-112043 PLC beta mediated events 2.038488e-01 0.691
R-HSA-1266738 Developmental Biology 2.437818e-01 0.613
R-HSA-5617833 Cilium Assembly 1.940118e-01 0.712
R-HSA-6783589 Interleukin-6 family signaling 1.468552e-01 0.833
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 1.190274e-01 0.924
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 3.052288e-01 0.515
R-HSA-451927 Interleukin-2 family signaling 2.850726e-01 0.545
R-HSA-3323169 Defects in biotin (Btn) metabolism 2.365167e-01 0.626
R-HSA-9671555 Signaling by PDGFR in disease 1.240918e-01 0.906
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 1.391724e-01 0.856
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 3.022283e-01 0.520
R-HSA-157858 Gap junction trafficking and regulation 1.383294e-01 0.859
R-HSA-5673000 RAF activation 2.354269e-01 0.628
R-HSA-4086400 PCP/CE pathway 3.052288e-01 0.515
R-HSA-168256 Immune System 1.425638e-01 0.846
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 1.135625e-01 0.945
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 2.535015e-01 0.596
R-HSA-9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... 1.315818e-01 0.881
R-HSA-3700989 Transcriptional Regulation by TP53 3.013589e-01 0.521
R-HSA-9010642 ROBO receptors bind AKAP5 2.191464e-01 0.659
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 1.326928e-01 0.877
R-HSA-9700206 Signaling by ALK in cancer 1.326928e-01 0.877
R-HSA-9730414 MITF-M-regulated melanocyte development 2.725131e-01 0.565
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 1.468552e-01 0.833
R-HSA-8863678 Neurodegenerative Diseases 1.468552e-01 0.833
R-HSA-5633007 Regulation of TP53 Activity 2.142309e-01 0.669
R-HSA-6804757 Regulation of TP53 Degradation 2.519588e-01 0.599
R-HSA-9683686 Maturation of spike protein 2.535015e-01 0.596
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 1.703812e-01 0.769
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 3.329374e-01 0.478
R-HSA-9907900 Proteasome assembly 3.262305e-01 0.486
R-HSA-373755 Semaphorin interactions 2.154030e-01 0.667
R-HSA-917937 Iron uptake and transport 2.869789e-01 0.542
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 3.101297e-01 0.508
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 3.252303e-01 0.488
R-HSA-3928662 EPHB-mediated forward signaling 1.135696e-01 0.945
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 1.344876e-01 0.871
R-HSA-6806003 Regulation of TP53 Expression and Degradation 2.767986e-01 0.558
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 3.180386e-01 0.498
R-HSA-198323 AKT phosphorylates targets in the cytosol 3.022283e-01 0.520
R-HSA-8856688 Golgi-to-ER retrograde transport 1.194595e-01 0.923
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 1.315818e-01 0.881
R-HSA-9020558 Interleukin-2 signaling 2.701096e-01 0.568
R-HSA-114452 Activation of BH3-only proteins 1.944740e-01 0.711
R-HSA-9692914 SARS-CoV-1-host interactions 2.752212e-01 0.560
R-HSA-1226099 Signaling by FGFR in disease 2.809138e-01 0.551
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 2.191464e-01 0.659
R-HSA-391160 Signal regulatory protein family interactions 3.329374e-01 0.478
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 1.934633e-01 0.713
R-HSA-163685 Integration of energy metabolism 2.626770e-01 0.581
R-HSA-9958790 SLC-mediated transport of inorganic anions 2.685189e-01 0.571
R-HSA-376176 Signaling by ROBO receptors 2.354183e-01 0.628
R-HSA-170834 Signaling by TGF-beta Receptor Complex 2.267157e-01 0.645
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 2.107644e-01 0.676
R-HSA-9008059 Interleukin-37 signaling 1.944740e-01 0.711
R-HSA-168316 Assembly of Viral Components at the Budding Site 1.456345e-01 0.837
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 1.116050e-01 0.952
R-HSA-1251985 Nuclear signaling by ERBB4 2.850726e-01 0.545
R-HSA-9694516 SARS-CoV-2 Infection 2.123462e-01 0.673
R-HSA-111465 Apoptotic cleavage of cellular proteins 2.107644e-01 0.676
R-HSA-9679506 SARS-CoV Infections 3.176604e-01 0.498
R-HSA-8853659 RET signaling 2.519588e-01 0.599
R-HSA-193704 p75 NTR receptor-mediated signalling 2.362466e-01 0.627
R-HSA-6783310 Fanconi Anemia Pathway 3.343962e-01 0.476
R-HSA-76009 Platelet Aggregation (Plug Formation) 3.343962e-01 0.476
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 3.343962e-01 0.476
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 3.343962e-01 0.476
R-HSA-9824272 Somitogenesis 3.343962e-01 0.476
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 3.343962e-01 0.476
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 3.343962e-01 0.476
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 3.343962e-01 0.476
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 3.343962e-01 0.476
R-HSA-72613 Eukaryotic Translation Initiation 3.353248e-01 0.475
R-HSA-72737 Cap-dependent Translation Initiation 3.353248e-01 0.475
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 3.361797e-01 0.473
R-HSA-9007101 Rab regulation of trafficking 3.403776e-01 0.468
R-HSA-2980736 Peptide hormone metabolism 3.403776e-01 0.468
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 3.425328e-01 0.465
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 3.425328e-01 0.465
R-HSA-212436 Generic Transcription Pathway 3.450205e-01 0.462
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 3.477827e-01 0.459
R-HSA-170670 Adenylate cyclase inhibitory pathway 3.477827e-01 0.459
R-HSA-196299 Beta-catenin phosphorylation cascade 3.477827e-01 0.459
R-HSA-73780 RNA Polymerase III Chain Elongation 3.477827e-01 0.459
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 3.477827e-01 0.459
R-HSA-3270619 IRF3-mediated induction of type I IFN 3.477827e-01 0.459
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 3.477827e-01 0.459
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 3.477827e-01 0.459
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 3.477827e-01 0.459
R-HSA-174362 Transport and metabolism of PAPS 3.477827e-01 0.459
R-HSA-399954 Sema3A PAK dependent Axon repulsion 3.477827e-01 0.459
R-HSA-9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 3.477827e-01 0.459
R-HSA-9673770 Signaling by PDGFRA extracellular domain mutants 3.477827e-01 0.459
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 3.477827e-01 0.459
R-HSA-446353 Cell-extracellular matrix interactions 3.477827e-01 0.459
R-HSA-168273 Influenza Viral RNA Transcription and Replication 3.493869e-01 0.457
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 3.506377e-01 0.455
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 3.506377e-01 0.455
R-HSA-1852241 Organelle biogenesis and maintenance 3.572610e-01 0.447
R-HSA-9634597 GPER1 signaling 3.587083e-01 0.445
R-HSA-381038 XBP1(S) activates chaperone genes 3.600870e-01 0.444
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 3.600870e-01 0.444
R-HSA-3371556 Cellular response to heat stress 3.606044e-01 0.443
R-HSA-176412 Phosphorylation of the APC/C 3.622986e-01 0.441
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 3.622986e-01 0.441
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 3.622986e-01 0.441
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 3.622986e-01 0.441
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 3.622986e-01 0.441
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 3.622986e-01 0.441
R-HSA-169893 Prolonged ERK activation events 3.622986e-01 0.441
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 3.622986e-01 0.441
R-HSA-9945266 Differentiation of T cells 3.622986e-01 0.441
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 3.622986e-01 0.441
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 3.622986e-01 0.441
R-HSA-168268 Virus Assembly and Release 3.622986e-01 0.441
R-HSA-9711097 Cellular response to starvation 3.626223e-01 0.441
R-HSA-9766229 Degradation of CDH1 3.667420e-01 0.436
R-HSA-69563 p53-Dependent G1 DNA Damage Response 3.667420e-01 0.436
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 3.667420e-01 0.436
R-HSA-9006936 Signaling by TGFB family members 3.714539e-01 0.430
R-HSA-156902 Peptide chain elongation 3.722224e-01 0.429
R-HSA-597592 Post-translational protein modification 3.750353e-01 0.426
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 3.764922e-01 0.424
R-HSA-3000471 Scavenging by Class B Receptors 3.764922e-01 0.424
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 3.764922e-01 0.424
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 3.764922e-01 0.424
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 3.764922e-01 0.424
R-HSA-918233 TRAF3-dependent IRF activation pathway 3.764922e-01 0.424
R-HSA-432047 Passive transport by Aquaporins 3.764922e-01 0.424
R-HSA-6787450 tRNA modification in the mitochondrion 3.764922e-01 0.424
R-HSA-9675151 Disorders of Developmental Biology 3.764922e-01 0.424
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 3.903403e-01 0.409
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 3.903708e-01 0.409
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 3.903708e-01 0.409
R-HSA-139853 Elevation of cytosolic Ca2+ levels 3.903708e-01 0.409
R-HSA-9768759 Regulation of NPAS4 gene expression 3.903708e-01 0.409
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 3.905991e-01 0.408
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 3.905991e-01 0.408
R-HSA-9634815 Transcriptional Regulation by NPAS4 3.905991e-01 0.408
R-HSA-5339562 Uptake and actions of bacterial toxins 3.905991e-01 0.408
R-HSA-114608 Platelet degranulation 3.959321e-01 0.402
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 3.963519e-01 0.402
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 3.984631e-01 0.400
R-HSA-9639288 Amino acids regulate mTORC1 3.984631e-01 0.400
R-HSA-187037 Signaling by NTRK1 (TRKA) 4.009589e-01 0.397
R-HSA-156842 Eukaryotic Translation Elongation 4.023478e-01 0.395
R-HSA-73980 RNA Polymerase III Transcription Termination 4.039413e-01 0.394
R-HSA-3928664 Ephrin signaling 4.039413e-01 0.394
R-HSA-9665348 Signaling by ERBB2 ECD mutants 4.039413e-01 0.394
R-HSA-9614657 FOXO-mediated transcription of cell death genes 4.039413e-01 0.394
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 4.039413e-01 0.394
R-HSA-6804760 Regulation of TP53 Activity through Methylation 4.039413e-01 0.394
R-HSA-156711 Polo-like kinase mediated events 4.039413e-01 0.394
R-HSA-72649 Translation initiation complex formation 4.062797e-01 0.391
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 4.062797e-01 0.391
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 4.172105e-01 0.380
R-HSA-937041 IKK complex recruitment mediated by RIP1 4.172105e-01 0.380
R-HSA-9709603 Impaired BRCA2 binding to PALB2 4.172105e-01 0.380
R-HSA-8964058 HDL remodeling 4.172105e-01 0.380
R-HSA-9754189 Germ layer formation at gastrulation 4.172105e-01 0.380
R-HSA-1834941 STING mediated induction of host immune responses 4.172105e-01 0.380
R-HSA-9834899 Specification of the neural plate border 4.172105e-01 0.380
R-HSA-110320 Translesion Synthesis by POLH 4.172105e-01 0.380
R-HSA-1480926 O2/CO2 exchange in erythrocytes 4.172105e-01 0.380
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 4.172105e-01 0.380
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 4.172105e-01 0.380
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 4.172105e-01 0.380
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 4.202292e-01 0.377
R-HSA-5576891 Cardiac conduction 4.209858e-01 0.376
R-HSA-72702 Ribosomal scanning and start codon recognition 4.217637e-01 0.375
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 4.217637e-01 0.375
R-HSA-109606 Intrinsic Pathway for Apoptosis 4.217637e-01 0.375
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 4.220534e-01 0.375
R-HSA-9909396 Circadian clock 4.259690e-01 0.371
R-HSA-72689 Formation of a pool of free 40S subunits 4.261509e-01 0.370
R-HSA-72764 Eukaryotic Translation Termination 4.261509e-01 0.370
R-HSA-9006925 Intracellular signaling by second messengers 4.269027e-01 0.370
R-HSA-73857 RNA Polymerase II Transcription 4.274135e-01 0.369
R-HSA-9764561 Regulation of CDH1 Function 4.294279e-01 0.367
R-HSA-2980766 Nuclear Envelope Breakdown 4.294279e-01 0.367
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 4.294279e-01 0.367
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 4.301851e-01 0.366
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 4.301851e-01 0.366
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 4.301851e-01 0.366
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 4.301851e-01 0.366
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 4.301851e-01 0.366
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 4.301851e-01 0.366
R-HSA-389977 Post-chaperonin tubulin folding pathway 4.301851e-01 0.366
R-HSA-9823730 Formation of definitive endoderm 4.301851e-01 0.366
R-HSA-140875 Common Pathway of Fibrin Clot Formation 4.301851e-01 0.366
R-HSA-445144 Signal transduction by L1 4.301851e-01 0.366
R-HSA-373753 Nephrin family interactions 4.301851e-01 0.366
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 4.309414e-01 0.366
R-HSA-5607764 CLEC7A (Dectin-1) signaling 4.320514e-01 0.364
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 4.370381e-01 0.359
R-HSA-8878159 Transcriptional regulation by RUNX3 4.379298e-01 0.359
R-HSA-9678108 SARS-CoV-1 Infection 4.417794e-01 0.355
R-HSA-392499 Metabolism of proteins 4.423741e-01 0.354
R-HSA-5602498 MyD88 deficiency (TLR2/4) 4.428717e-01 0.354
R-HSA-198753 ERK/MAPK targets 4.428717e-01 0.354
R-HSA-9819196 Zygotic genome activation (ZGA) 4.428717e-01 0.354
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 4.428717e-01 0.354
R-HSA-210991 Basigin interactions 4.428717e-01 0.354
R-HSA-9033241 Peroxisomal protein import 4.445929e-01 0.352
R-HSA-429914 Deadenylation-dependent mRNA decay 4.445929e-01 0.352
R-HSA-194441 Metabolism of non-coding RNA 4.445929e-01 0.352
R-HSA-191859 snRNP Assembly 4.445929e-01 0.352
R-HSA-352230 Amino acid transport across the plasma membrane 4.445929e-01 0.352
R-HSA-3858494 Beta-catenin independent WNT signaling 4.507100e-01 0.346
R-HSA-8943724 Regulation of PTEN gene transcription 4.520912e-01 0.345
R-HSA-1227986 Signaling by ERBB2 4.520912e-01 0.345
R-HSA-351202 Metabolism of polyamines 4.520912e-01 0.345
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 4.552766e-01 0.342
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 4.552766e-01 0.342
R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling 4.552766e-01 0.342
R-HSA-8876384 Listeria monocytogenes entry into host cells 4.552766e-01 0.342
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 4.552766e-01 0.342
R-HSA-5610787 Hedgehog 'off' state 4.554233e-01 0.342
R-HSA-168325 Viral Messenger RNA Synthesis 4.595316e-01 0.338
R-HSA-8939902 Regulation of RUNX2 expression and activity 4.595316e-01 0.338
R-HSA-450294 MAP kinase activation 4.595316e-01 0.338
R-HSA-5358351 Signaling by Hedgehog 4.605131e-01 0.337
R-HSA-2408557 Selenocysteine synthesis 4.612042e-01 0.336
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 4.669130e-01 0.331
R-HSA-6784531 tRNA processing in the nucleus 4.669130e-01 0.331
R-HSA-9707616 Heme signaling 4.669130e-01 0.331
R-HSA-186797 Signaling by PDGF 4.669130e-01 0.331
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 4.669587e-01 0.331
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 4.674060e-01 0.330
R-HSA-350054 Notch-HLH transcription pathway 4.674060e-01 0.330
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 4.674060e-01 0.330
R-HSA-112409 RAF-independent MAPK1/3 activation 4.674060e-01 0.330
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 4.674060e-01 0.330
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 4.674060e-01 0.330
R-HSA-192823 Viral mRNA Translation 4.726859e-01 0.325
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 4.742344e-01 0.324
R-HSA-8848021 Signaling by PTK6 4.742344e-01 0.324
R-HSA-111885 Opioid Signalling 4.783850e-01 0.320
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 4.783850e-01 0.320
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 4.792660e-01 0.319
R-HSA-8854691 Interleukin-20 family signaling 4.792660e-01 0.319
R-HSA-879518 Organic anion transport by SLCO transporters 4.792660e-01 0.319
R-HSA-1369062 ABC transporters in lipid homeostasis 4.792660e-01 0.319
R-HSA-982772 Growth hormone receptor signaling 4.792660e-01 0.319
R-HSA-162599 Late Phase of HIV Life Cycle 4.847468e-01 0.314
R-HSA-1234174 Cellular response to hypoxia 4.886932e-01 0.311
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 4.886932e-01 0.311
R-HSA-382551 Transport of small molecules 4.894538e-01 0.310
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 4.896963e-01 0.310
R-HSA-8963898 Plasma lipoprotein assembly 4.908627e-01 0.309
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 4.908627e-01 0.309
R-HSA-5621575 CD209 (DC-SIGN) signaling 4.908627e-01 0.309
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 5.008869e-01 0.300
R-HSA-983712 Ion channel transport 5.017418e-01 0.300
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 5.022018e-01 0.299
R-HSA-9932444 ATP-dependent chromatin remodelers 5.022018e-01 0.299
R-HSA-9932451 SWI/SNF chromatin remodelers 5.022018e-01 0.299
R-HSA-70221 Glycogen breakdown (glycogenolysis) 5.022018e-01 0.299
R-HSA-9830364 Formation of the nephric duct 5.022018e-01 0.299
R-HSA-5218921 VEGFR2 mediated cell proliferation 5.022018e-01 0.299
R-HSA-5685942 HDR through Homologous Recombination (HRR) 5.029009e-01 0.299
R-HSA-9958863 SLC-mediated transport of amino acids 5.029009e-01 0.299
R-HSA-2672351 Stimuli-sensing channels 5.064353e-01 0.295
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 5.064353e-01 0.295
R-HSA-199977 ER to Golgi Anterograde Transport 5.085361e-01 0.294
R-HSA-168898 Toll-like Receptor Cascades 5.101150e-01 0.292
R-HSA-6798695 Neutrophil degranulation 5.107821e-01 0.292
R-HSA-975155 MyD88 dependent cascade initiated on endosome 5.119517e-01 0.291
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 5.132353e-01 0.290
R-HSA-166520 Signaling by NTRKs 5.132353e-01 0.290
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 5.132890e-01 0.290
R-HSA-525793 Myogenesis 5.132890e-01 0.290
R-HSA-5689901 Metalloprotease DUBs 5.132890e-01 0.290
R-HSA-166166 MyD88-independent TLR4 cascade 5.174354e-01 0.286
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 5.174354e-01 0.286
R-HSA-9856651 MITF-M-dependent gene expression 5.225716e-01 0.282
R-HSA-9679191 Potential therapeutics for SARS 5.225716e-01 0.282
R-HSA-195253 Degradation of beta-catenin by the destruction complex 5.237292e-01 0.281
R-HSA-448424 Interleukin-17 signaling 5.237292e-01 0.281
R-HSA-73863 RNA Polymerase I Transcription Termination 5.241300e-01 0.281
R-HSA-8949613 Cristae formation 5.241300e-01 0.281
R-HSA-201451 Signaling by BMP 5.241300e-01 0.281
R-HSA-389357 CD28 dependent PI3K/Akt signaling 5.241300e-01 0.281
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 5.241300e-01 0.281
R-HSA-9755511 KEAP1-NFE2L2 pathway 5.272078e-01 0.278
R-HSA-5632684 Hedgehog 'on' state 5.305407e-01 0.275
R-HSA-5620920 Cargo trafficking to the periciliary membrane 5.305407e-01 0.275
R-HSA-446652 Interleukin-1 family signaling 5.318222e-01 0.274
R-HSA-171319 Telomere Extension By Telomerase 5.347301e-01 0.272
R-HSA-77387 Insulin receptor recycling 5.347301e-01 0.272
R-HSA-9609507 Protein localization 5.364144e-01 0.270
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 5.372856e-01 0.270
R-HSA-73887 Death Receptor Signaling 5.409840e-01 0.267
R-HSA-69052 Switching of origins to a post-replicative state 5.439637e-01 0.264
R-HSA-9709570 Impaired BRCA2 binding to RAD51 5.450948e-01 0.264
R-HSA-9674555 Signaling by CSF3 (G-CSF) 5.450948e-01 0.264
R-HSA-9759475 Regulation of CDH11 Expression and Function 5.450948e-01 0.264
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 5.450948e-01 0.264
R-HSA-418360 Platelet calcium homeostasis 5.450948e-01 0.264
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 5.450948e-01 0.264
R-HSA-9664565 Signaling by ERBB2 KD Mutants 5.450948e-01 0.264
R-HSA-180024 DARPP-32 events 5.450948e-01 0.264
R-HSA-9013694 Signaling by NOTCH4 5.505746e-01 0.259
R-HSA-1236394 Signaling by ERBB4 5.505746e-01 0.259
R-HSA-162587 HIV Life Cycle 5.545539e-01 0.256
R-HSA-909733 Interferon alpha/beta signaling 5.548643e-01 0.256
R-HSA-76046 RNA Polymerase III Transcription Initiation 5.552292e-01 0.256
R-HSA-1250196 SHC1 events in ERBB2 signaling 5.552292e-01 0.256
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 5.552292e-01 0.256
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 5.552292e-01 0.256
R-HSA-5663205 Infectious disease 5.581295e-01 0.253
R-HSA-5689603 UCH proteinases 5.635932e-01 0.249
R-HSA-9020591 Interleukin-12 signaling 5.635932e-01 0.249
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 5.651384e-01 0.248
R-HSA-2129379 Molecules associated with elastic fibres 5.651384e-01 0.248
R-HSA-9833109 Evasion by RSV of host interferon responses 5.651384e-01 0.248
R-HSA-186763 Downstream signal transduction 5.651384e-01 0.248
R-HSA-2219528 PI3K/AKT Signaling in Cancer 5.703679e-01 0.244
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 5.748275e-01 0.240
R-HSA-4791275 Signaling by WNT in cancer 5.748275e-01 0.240
R-HSA-9675126 Diseases of mitotic cell cycle 5.748275e-01 0.240
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 5.754612e-01 0.240
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 5.754612e-01 0.240
R-HSA-383280 Nuclear Receptor transcription pathway 5.763396e-01 0.239
R-HSA-5619084 ABC transporter disorders 5.763396e-01 0.239
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 5.843013e-01 0.233
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 5.843013e-01 0.233
R-HSA-9733709 Cardiogenesis 5.843013e-01 0.233
R-HSA-397795 G-protein beta:gamma signalling 5.843013e-01 0.233
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 5.843013e-01 0.233
R-HSA-5675482 Regulation of necroptotic cell death 5.843013e-01 0.233
R-HSA-9759194 Nuclear events mediated by NFE2L2 5.855344e-01 0.232
R-HSA-9833482 PKR-mediated signaling 5.888125e-01 0.230
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 5.905137e-01 0.229
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 5.905137e-01 0.229
R-HSA-180534 Vpu mediated degradation of CD4 5.935645e-01 0.227
R-HSA-5223345 Miscellaneous transport and binding events 5.935645e-01 0.227
R-HSA-162909 Host Interactions of HIV factors 6.003562e-01 0.222
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 6.026219e-01 0.220
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 6.026219e-01 0.220
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 6.026219e-01 0.220
R-HSA-901042 Calnexin/calreticulin cycle 6.026219e-01 0.220
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 6.026219e-01 0.220
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 6.026219e-01 0.220
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 6.026219e-01 0.220
R-HSA-5686938 Regulation of TLR by endogenous ligand 6.026219e-01 0.220
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 6.026219e-01 0.220
R-HSA-9768919 NPAS4 regulates expression of target genes 6.026219e-01 0.220
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 6.070077e-01 0.217
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 6.114779e-01 0.214
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 6.114779e-01 0.214
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 6.114779e-01 0.214
R-HSA-169911 Regulation of Apoptosis 6.114779e-01 0.214
R-HSA-917977 Transferrin endocytosis and recycling 6.114779e-01 0.214
R-HSA-187687 Signalling to ERKs 6.114779e-01 0.214
R-HSA-3296482 Defects in vitamin and cofactor metabolism 6.114779e-01 0.214
R-HSA-72306 tRNA processing 6.149110e-01 0.211
R-HSA-5621481 C-type lectin receptors (CLRs) 6.190240e-01 0.208
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 6.201372e-01 0.208
R-HSA-74158 RNA Polymerase III Transcription 6.201372e-01 0.208
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 6.201372e-01 0.208
R-HSA-180585 Vif-mediated degradation of APOBEC3G 6.201372e-01 0.208
R-HSA-114604 GPVI-mediated activation cascade 6.201372e-01 0.208
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 6.201372e-01 0.208
R-HSA-163560 Triglyceride catabolism 6.201372e-01 0.208
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 6.245863e-01 0.204
R-HSA-933541 TRAF6 mediated IRF7 activation 6.286040e-01 0.202
R-HSA-4641258 Degradation of DVL 6.286040e-01 0.202
R-HSA-4641257 Degradation of AXIN 6.286040e-01 0.202
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 6.286040e-01 0.202
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 6.286040e-01 0.202
R-HSA-6785470 tRNA processing in the mitochondrion 6.368825e-01 0.196
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 6.368825e-01 0.196
R-HSA-1566948 Elastic fibre formation 6.368825e-01 0.196
R-HSA-5213460 RIPK1-mediated regulated necrosis 6.368825e-01 0.196
R-HSA-1643685 Disease 6.379374e-01 0.195
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 6.449771e-01 0.190
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 6.449771e-01 0.190
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 6.449771e-01 0.190
R-HSA-1236974 ER-Phagosome pathway 6.470706e-01 0.189
R-HSA-112315 Transmission across Chemical Synapses 6.524480e-01 0.185
R-HSA-162906 HIV Infection 6.524677e-01 0.185
R-HSA-202424 Downstream TCR signaling 6.525226e-01 0.185
R-HSA-9646399 Aggrephagy 6.528916e-01 0.185
R-HSA-9854311 Maturation of TCA enzymes and regulation of TCA cycle 6.528916e-01 0.185
R-HSA-3371568 Attenuation phase 6.528916e-01 0.185
R-HSA-9604323 Negative regulation of NOTCH4 signaling 6.528916e-01 0.185
R-HSA-8868766 rRNA processing in the mitochondrion 6.528916e-01 0.185
R-HSA-8941858 Regulation of RUNX3 expression and activity 6.528916e-01 0.185
R-HSA-8982491 Glycogen metabolism 6.528916e-01 0.185
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 6.606302e-01 0.180
R-HSA-5362768 Hh mutants are degraded by ERAD 6.606302e-01 0.180
R-HSA-9694548 Maturation of spike protein 6.606302e-01 0.180
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 6.606302e-01 0.180
R-HSA-5423646 Aflatoxin activation and detoxification 6.606302e-01 0.180
R-HSA-9932298 Degradation of CRY and PER proteins 6.681968e-01 0.175
R-HSA-5610780 Degradation of GLI1 by the proteasome 6.681968e-01 0.175
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 6.681968e-01 0.175
R-HSA-5610783 Degradation of GLI2 by the proteasome 6.681968e-01 0.175
R-HSA-6811438 Intra-Golgi traffic 6.681968e-01 0.175
R-HSA-5675221 Negative regulation of MAPK pathway 6.681968e-01 0.175
R-HSA-9683701 Translation of Structural Proteins 6.681968e-01 0.175
R-HSA-74752 Signaling by Insulin receptor 6.684767e-01 0.175
R-HSA-991365 Activation of GABAB receptors 6.755951e-01 0.170
R-HSA-977444 GABA B receptor activation 6.755951e-01 0.170
R-HSA-73762 RNA Polymerase I Transcription Initiation 6.755951e-01 0.170
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 6.755951e-01 0.170
R-HSA-400508 Incretin synthesis, secretion, and inactivation 6.755951e-01 0.170
R-HSA-6807070 PTEN Regulation 6.817841e-01 0.166
R-HSA-5387390 Hh mutants abrogate ligand secretion 6.828289e-01 0.166
R-HSA-913531 Interferon Signaling 6.886674e-01 0.162
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 6.899018e-01 0.161
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 6.937471e-01 0.159
R-HSA-5673001 RAF/MAP kinase cascade 6.948411e-01 0.158
R-HSA-4608870 Asymmetric localization of PCP proteins 6.968174e-01 0.157
R-HSA-5678895 Defective CFTR causes cystic fibrosis 6.968174e-01 0.157
R-HSA-8957275 Post-translational protein phosphorylation 7.034020e-01 0.153
R-HSA-975871 MyD88 cascade initiated on plasma membrane 7.034020e-01 0.153
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 7.034020e-01 0.153
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 7.034020e-01 0.153
R-HSA-72165 mRNA Splicing - Minor Pathway 7.035792e-01 0.153
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 7.035792e-01 0.153
R-HSA-9675135 Diseases of DNA repair 7.035792e-01 0.153
R-HSA-1257604 PIP3 activates AKT signaling 7.121182e-01 0.147
R-HSA-382556 ABC-family proteins mediated transport 7.128027e-01 0.147
R-HSA-5684996 MAPK1/MAPK3 signaling 7.149319e-01 0.146
R-HSA-8963899 Plasma lipoprotein remodeling 7.166550e-01 0.145
R-HSA-389356 Co-stimulation by CD28 7.166550e-01 0.145
R-HSA-70263 Gluconeogenesis 7.166550e-01 0.145
R-HSA-9020702 Interleukin-1 signaling 7.174090e-01 0.144
R-HSA-5619115 Disorders of transmembrane transporters 7.174814e-01 0.144
R-HSA-69242 S Phase 7.213927e-01 0.142
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 7.229755e-01 0.141
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 7.229755e-01 0.141
R-HSA-73893 DNA Damage Bypass 7.229755e-01 0.141
R-HSA-9758941 Gastrulation 7.251349e-01 0.140
R-HSA-109704 PI3K Cascade 7.291554e-01 0.137
R-HSA-5658442 Regulation of RAS by GAPs 7.291554e-01 0.137
R-HSA-948021 Transport to the Golgi and subsequent modification 7.324061e-01 0.135
R-HSA-3371571 HSF1-dependent transactivation 7.351979e-01 0.134
R-HSA-1169091 Activation of NF-kappaB in B cells 7.351979e-01 0.134
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 7.351979e-01 0.134
R-HSA-5358346 Hedgehog ligand biogenesis 7.351979e-01 0.134
R-HSA-9833110 RSV-host interactions 7.352173e-01 0.134
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 7.356013e-01 0.133
R-HSA-72187 mRNA 3'-end processing 7.411059e-01 0.130
R-HSA-68949 Orc1 removal from chromatin 7.411059e-01 0.130
R-HSA-6794361 Neurexins and neuroligins 7.411059e-01 0.130
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 7.411059e-01 0.130
R-HSA-1989781 PPARA activates gene expression 7.467686e-01 0.127
R-HSA-8948751 Regulation of PTEN stability and activity 7.468824e-01 0.127
R-HSA-69239 Synthesis of DNA 7.479399e-01 0.126
R-HSA-1236975 Antigen processing-Cross presentation 7.520628e-01 0.124
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 7.525304e-01 0.123
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 7.536716e-01 0.123
R-HSA-418597 G alpha (z) signalling events 7.580527e-01 0.120
R-HSA-202403 TCR signaling 7.601349e-01 0.119
R-HSA-397014 Muscle contraction 7.659849e-01 0.116
R-HSA-1483249 Inositol phosphate metabolism 7.679790e-01 0.115
R-HSA-112399 IRS-mediated signalling 7.687314e-01 0.114
R-HSA-1483166 Synthesis of PA 7.687314e-01 0.114
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 7.738931e-01 0.111
R-HSA-2408522 Selenoamino acid metabolism 7.766481e-01 0.110
R-HSA-180786 Extension of Telomeres 7.789400e-01 0.108
R-HSA-8979227 Triglyceride metabolism 7.789400e-01 0.108
R-HSA-186712 Regulation of beta-cell development 7.789400e-01 0.108
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 7.789400e-01 0.108
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 7.793271e-01 0.108
R-HSA-5628897 TP53 Regulates Metabolic Genes 7.830006e-01 0.106
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 7.838745e-01 0.106
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 7.838745e-01 0.106
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 7.838745e-01 0.106
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 7.838745e-01 0.106
R-HSA-977443 GABA receptor activation 7.838745e-01 0.106
R-HSA-2644603 Signaling by NOTCH1 in Cancer 7.838745e-01 0.106
R-HSA-5619102 SLC transporter disorders 7.859442e-01 0.105
R-HSA-449147 Signaling by Interleukins 7.869339e-01 0.104
R-HSA-73856 RNA Polymerase II Transcription Termination 7.886991e-01 0.103
R-HSA-2428928 IRS-related events triggered by IGF1R 7.886991e-01 0.103
R-HSA-76002 Platelet activation, signaling and aggregation 7.908567e-01 0.102
R-HSA-375165 NCAM signaling for neurite out-growth 7.934164e-01 0.100
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 7.934164e-01 0.100
R-HSA-1268020 Mitochondrial protein import 7.934164e-01 0.100
R-HSA-1592230 Mitochondrial biogenesis 7.937011e-01 0.100
R-HSA-6799198 Complex I biogenesis 7.980286e-01 0.098
R-HSA-8878166 Transcriptional regulation by RUNX2 8.005738e-01 0.097
R-HSA-2428924 IGF1R signaling cascade 8.025381e-01 0.096
R-HSA-936837 Ion transport by P-type ATPases 8.025381e-01 0.096
R-HSA-74751 Insulin receptor signalling cascade 8.025381e-01 0.096
R-HSA-109582 Hemostasis 8.049006e-01 0.094
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 8.069472e-01 0.093
R-HSA-6782315 tRNA modification in the nucleus and cytosol 8.112581e-01 0.091
R-HSA-9830369 Kidney development 8.154731e-01 0.089
R-HSA-6809371 Formation of the cornified envelope 8.168757e-01 0.088
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 8.195941e-01 0.086
R-HSA-913709 O-linked glycosylation of mucins 8.195941e-01 0.086
R-HSA-5218859 Regulated Necrosis 8.195941e-01 0.086
R-HSA-168249 Innate Immune System 8.201770e-01 0.086
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 8.260761e-01 0.083
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 8.275629e-01 0.082
R-HSA-69202 Cyclin E associated events during G1/S transition 8.275629e-01 0.082
R-HSA-75105 Fatty acyl-CoA biosynthesis 8.275629e-01 0.082
R-HSA-425407 SLC-mediated transmembrane transport 8.305434e-01 0.081
R-HSA-975634 Retinoid metabolism and transport 8.314146e-01 0.080
R-HSA-5683057 MAPK family signaling cascades 8.337364e-01 0.079
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 8.351806e-01 0.078
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 8.351806e-01 0.078
R-HSA-4086398 Ca2+ pathway 8.388626e-01 0.076
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 8.403733e-01 0.076
R-HSA-1222556 ROS and RNS production in phagocytes 8.424626e-01 0.074
R-HSA-1474228 Degradation of the extracellular matrix 8.459480e-01 0.073
R-HSA-71403 Citric acid cycle (TCA cycle) 8.459824e-01 0.073
R-HSA-1980143 Signaling by NOTCH1 8.494238e-01 0.071
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 8.527885e-01 0.069
R-HSA-9694635 Translation of Structural Proteins 8.527885e-01 0.069
R-HSA-216083 Integrin cell surface interactions 8.560782e-01 0.067
R-HSA-9955298 SLC-mediated transport of organic anions 8.560782e-01 0.067
R-HSA-112316 Neuronal System 8.603116e-01 0.065
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 8.613179e-01 0.065
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 8.624393e-01 0.064
R-HSA-6806667 Metabolism of fat-soluble vitamins 8.655139e-01 0.063
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 8.655139e-01 0.063
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 8.707725e-01 0.060
R-HSA-9707564 Cytoprotection by HMOX1 8.714591e-01 0.060
R-HSA-6794362 Protein-protein interactions at synapses 8.771421e-01 0.057
R-HSA-5687128 MAPK6/MAPK4 signaling 8.771421e-01 0.057
R-HSA-2871837 FCERI mediated NF-kB activation 8.796322e-01 0.056
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 8.798889e-01 0.056
R-HSA-9734767 Developmental Cell Lineages 8.804862e-01 0.055
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 8.825745e-01 0.054
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 8.825745e-01 0.054
R-HSA-9711123 Cellular response to chemical stress 8.885472e-01 0.051
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 8.918762e-01 0.050
R-HSA-373080 Class B/2 (Secretin family receptors) 8.927312e-01 0.049
R-HSA-1474244 Extracellular matrix organization 8.965040e-01 0.047
R-HSA-9772573 Late SARS-CoV-2 Infection Events 8.997694e-01 0.046
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 9.020116e-01 0.045
R-HSA-1280215 Cytokine Signaling in Immune system 9.032004e-01 0.044
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 9.042038e-01 0.044
R-HSA-9837999 Mitochondrial protein degradation 9.042038e-01 0.044
R-HSA-1474290 Collagen formation 9.042038e-01 0.044
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 9.063470e-01 0.043
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 9.064091e-01 0.043
R-HSA-2168880 Scavenging of heme from plasma 9.084424e-01 0.042
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 9.104911e-01 0.041
R-HSA-422356 Regulation of insulin secretion 9.144523e-01 0.039
R-HSA-9614085 FOXO-mediated transcription 9.163669e-01 0.038
R-HSA-9009391 Extra-nuclear estrogen signaling 9.200688e-01 0.036
R-HSA-418555 G alpha (s) signalling events 9.275425e-01 0.033
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 9.301665e-01 0.031
R-HSA-9664433 Leishmania parasite growth and survival 9.301665e-01 0.031
R-HSA-418346 Platelet homeostasis 9.302223e-01 0.031
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 9.314446e-01 0.031
R-HSA-6803157 Antimicrobial peptides 9.376935e-01 0.028
R-HSA-72766 Translation 9.397360e-01 0.027
R-HSA-2871809 FCERI mediated Ca+2 mobilization 9.456132e-01 0.024
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 9.509906e-01 0.022
R-HSA-8957322 Metabolism of steroids 9.510196e-01 0.022
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 9.546332e-01 0.020
R-HSA-977606 Regulation of Complement cascade 9.566446e-01 0.019
R-HSA-69206 G1/S Transition 9.576167e-01 0.019
R-HSA-1483206 Glycerophospholipid biosynthesis 9.601873e-01 0.018
R-HSA-199418 Negative regulation of the PI3K/AKT network 9.621606e-01 0.017
R-HSA-6805567 Keratinization 9.631026e-01 0.016
R-HSA-9843745 Adipogenesis 9.638391e-01 0.016
R-HSA-9824443 Parasitic Infection Pathways 9.658618e-01 0.015
R-HSA-9658195 Leishmania infection 9.658618e-01 0.015
R-HSA-5173105 O-linked glycosylation 9.691502e-01 0.014
R-HSA-388396 GPCR downstream signalling 9.707121e-01 0.013
R-HSA-9664417 Leishmania phagocytosis 9.711811e-01 0.013
R-HSA-9664422 FCGR3A-mediated phagocytosis 9.711811e-01 0.013
R-HSA-9664407 Parasite infection 9.711811e-01 0.013
R-HSA-446203 Asparagine N-linked glycosylation 9.715377e-01 0.013
R-HSA-166658 Complement cascade 9.748515e-01 0.011
R-HSA-453279 Mitotic G1 phase and G1/S transition 9.754162e-01 0.011
R-HSA-2187338 Visual phototransduction 9.759683e-01 0.011
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 9.767337e-01 0.010
R-HSA-372790 Signaling by GPCR 9.784586e-01 0.009
R-HSA-877300 Interferon gamma signaling 9.817034e-01 0.008
R-HSA-611105 Respiratory electron transport 9.883905e-01 0.005
R-HSA-1630316 Glycosaminoglycan metabolism 9.917494e-01 0.004
R-HSA-196854 Metabolism of vitamins and cofactors 9.921601e-01 0.003
R-HSA-1483257 Phospholipid metabolism 9.935559e-01 0.003
R-HSA-9824439 Bacterial Infection Pathways 9.952351e-01 0.002
R-HSA-418594 G alpha (i) signalling events 9.965317e-01 0.002
R-HSA-202733 Cell surface interactions at the vascular wall 9.970443e-01 0.001
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.974650e-01 0.001
R-HSA-416476 G alpha (q) signalling events 9.984058e-01 0.001
R-HSA-71291 Metabolism of amino acids and derivatives 9.988229e-01 0.001
R-HSA-8978868 Fatty acid metabolism 9.993666e-01 0.000
R-HSA-5668914 Diseases of metabolism 9.999633e-01 0.000
R-HSA-211859 Biological oxidations 9.999960e-01 0.000
R-HSA-500792 GPCR ligand binding 9.999992e-01 0.000
R-HSA-556833 Metabolism of lipids 9.999998e-01 0.000
R-HSA-9709957 Sensory Perception 1.000000e+00 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.817 0.051 2 0.878
CAMK1BCAMK1B 0.811 0.099 -3 0.914
RSK2RSK2 0.811 0.136 -3 0.848
MAPKAPK2MAPKAPK2 0.810 0.190 -3 0.811
CK2A2CK2A2 0.809 0.509 1 0.720
CDC7CDC7 0.809 0.015 1 0.859
PRKD1PRKD1 0.808 0.085 -3 0.856
GRK6GRK6 0.807 0.290 1 0.857
CAMK2GCAMK2G 0.807 0.129 2 0.820
PRPKPRPK 0.806 -0.022 -1 0.874
PIM3PIM3 0.806 0.087 -3 0.882
RAF1RAF1 0.805 -0.036 1 0.882
TBK1TBK1 0.805 -0.001 1 0.797
CAMK2BCAMK2B 0.805 0.200 2 0.796
PRKD2PRKD2 0.805 0.087 -3 0.840
MAPKAPK3MAPKAPK3 0.804 0.133 -3 0.841
P90RSKP90RSK 0.804 0.097 -3 0.847
AMPKA1AMPKA1 0.804 0.089 -3 0.893
IKKBIKKB 0.804 0.061 -2 0.761
MARK4MARK4 0.804 0.048 4 0.861
MOSMOS 0.804 0.029 1 0.883
FAM20CFAM20C 0.803 0.152 2 0.678
NDR2NDR2 0.803 0.041 -3 0.869
CLK3CLK3 0.802 0.040 1 0.813
TSSK2TSSK2 0.802 0.091 -5 0.880
CDKL1CDKL1 0.802 0.054 -3 0.864
IKKEIKKE 0.801 -0.003 1 0.794
PKN3PKN3 0.801 0.050 -3 0.875
PDHK4PDHK4 0.801 -0.075 1 0.888
CAMLCKCAMLCK 0.800 0.041 -2 0.876
CAMK2DCAMK2D 0.800 0.099 -3 0.878
NUAK2NUAK2 0.800 0.032 -3 0.896
AMPKA2AMPKA2 0.800 0.076 -3 0.876
PIM1PIM1 0.800 0.109 -3 0.855
SRPK1SRPK1 0.799 0.043 -3 0.830
TSSK1TSSK1 0.799 0.072 -3 0.903
ATRATR 0.799 0.031 1 0.855
HUNKHUNK 0.799 0.002 2 0.823
DSTYKDSTYK 0.798 -0.016 2 0.863
CK2A1CK2A1 0.798 0.468 1 0.701
CAMK2ACAMK2A 0.798 0.161 2 0.790
SKMLCKSKMLCK 0.798 0.031 -2 0.861
RIPK3RIPK3 0.798 -0.114 3 0.070
WNK1WNK1 0.798 -0.004 -2 0.884
NIM1NIM1 0.797 0.004 3 0.124
BMPR2BMPR2 0.797 -0.090 -2 0.916
MTORMTOR 0.797 -0.043 1 0.815
PDHK1PDHK1 0.797 -0.038 1 0.881
RSK3RSK3 0.797 0.060 -3 0.847
P70S6KBP70S6KB 0.796 0.064 -3 0.871
LATS2LATS2 0.796 0.063 -5 0.753
NIKNIK 0.796 -0.009 -3 0.909
GCN2GCN2 0.795 -0.145 2 0.781
NDR1NDR1 0.795 0.011 -3 0.880
NLKNLK 0.795 -0.041 1 0.844
DAPK2DAPK2 0.795 0.029 -3 0.903
IKKAIKKA 0.795 0.092 -2 0.743
ULK2ULK2 0.794 -0.097 2 0.788
GRK5GRK5 0.794 0.084 -3 0.838
QSKQSK 0.794 0.042 4 0.837
GRK7GRK7 0.793 0.299 1 0.777
ATMATM 0.793 0.060 1 0.800
PLK3PLK3 0.793 0.186 2 0.784
PKN2PKN2 0.793 0.001 -3 0.886
TGFBR2TGFBR2 0.793 -0.037 -2 0.833
SRPK2SRPK2 0.792 0.046 -3 0.771
PLK1PLK1 0.792 0.137 -2 0.849
CDKL5CDKL5 0.792 0.025 -3 0.857
WNK3WNK3 0.792 -0.090 1 0.854
HIPK4HIPK4 0.792 0.006 1 0.814
PKACGPKACG 0.791 0.053 -2 0.765
MELKMELK 0.791 0.027 -3 0.868
CAMK4CAMK4 0.791 0.029 -3 0.878
BCKDKBCKDK 0.791 -0.013 -1 0.842
GRK1GRK1 0.791 0.109 -2 0.775
BRSK1BRSK1 0.791 0.049 -3 0.861
PRKD3PRKD3 0.791 0.060 -3 0.831
MARK3MARK3 0.791 0.056 4 0.802
ERK5ERK5 0.791 -0.027 1 0.771
MST4MST4 0.791 -0.028 2 0.806
TGFBR1TGFBR1 0.791 0.124 -2 0.814
PKCDPKCD 0.790 0.013 2 0.761
RSK4RSK4 0.790 0.117 -3 0.816
MSK2MSK2 0.790 0.063 -3 0.814
SRPK3SRPK3 0.790 0.026 -3 0.807
SIKSIK 0.789 0.039 -3 0.839
MARK2MARK2 0.789 0.050 4 0.765
NUAK1NUAK1 0.789 0.011 -3 0.868
MSK1MSK1 0.788 0.084 -3 0.825
PAK1PAK1 0.788 0.046 -2 0.799
MYLK4MYLK4 0.788 0.043 -2 0.786
ICKICK 0.787 0.022 -3 0.883
RIPK1RIPK1 0.787 -0.114 1 0.854
ALK4ALK4 0.787 0.080 -2 0.845
MARK1MARK1 0.787 0.040 4 0.823
QIKQIK 0.787 -0.017 -3 0.873
PAK6PAK6 0.786 0.063 -2 0.737
GRK4GRK4 0.786 0.019 -2 0.825
PKACBPKACB 0.786 0.085 -2 0.701
BMPR1BBMPR1B 0.786 0.094 1 0.800
LATS1LATS1 0.785 0.087 -3 0.871
DNAPKDNAPK 0.785 0.083 1 0.759
MASTLMASTL 0.785 -0.134 -2 0.830
NEK6NEK6 0.785 -0.101 -2 0.890
CHK1CHK1 0.784 0.061 -3 0.869
PAK3PAK3 0.784 -0.003 -2 0.804
AURCAURC 0.784 0.020 -2 0.686
BRSK2BRSK2 0.784 -0.007 -3 0.873
NEK7NEK7 0.783 -0.147 -3 0.803
ULK1ULK1 0.783 -0.104 -3 0.795
ALK2ALK2 0.783 0.116 -2 0.828
PRKXPRKX 0.783 0.110 -3 0.770
KISKIS 0.783 -0.027 1 0.688
SGK3SGK3 0.783 0.091 -3 0.832
CHAK2CHAK2 0.782 -0.118 -1 0.827
MLK1MLK1 0.782 -0.131 2 0.777
CLK4CLK4 0.782 0.046 -3 0.852
MNK2MNK2 0.782 -0.007 -2 0.814
DLKDLK 0.781 -0.079 1 0.862
DYRK2DYRK2 0.781 0.027 1 0.705
CAMK1GCAMK1G 0.781 0.041 -3 0.847
AURBAURB 0.781 0.018 -2 0.681
ACVR2AACVR2A 0.780 0.079 -2 0.834
TTBK2TTBK2 0.780 -0.024 2 0.700
CLK2CLK2 0.780 0.071 -3 0.841
CLK1CLK1 0.780 0.039 -3 0.840
ANKRD3ANKRD3 0.780 -0.150 1 0.888
NEK9NEK9 0.780 -0.141 2 0.812
PKG2PKG2 0.780 0.045 -2 0.709
CAMK1DCAMK1D 0.780 0.102 -3 0.789
AKT2AKT2 0.779 0.061 -3 0.790
PAK2PAK2 0.779 0.009 -2 0.786
MAPKAPK5MAPKAPK5 0.778 0.006 -3 0.794
DCAMKL1DCAMKL1 0.778 0.055 -3 0.855
ACVR2BACVR2B 0.778 0.053 -2 0.835
SMG1SMG1 0.778 0.004 1 0.808
JNK2JNK2 0.777 0.052 1 0.619
PIM2PIM2 0.777 0.058 -3 0.834
IRE1IRE1 0.777 -0.131 1 0.814
AURAAURA 0.777 0.027 -2 0.646
IRE2IRE2 0.776 -0.116 2 0.756
SSTKSSTK 0.776 0.025 4 0.827
JNK3JNK3 0.776 0.048 1 0.652
MEK1MEK1 0.775 -0.081 2 0.834
PKRPKR 0.775 -0.078 1 0.863
CDK8CDK8 0.775 -0.024 1 0.664
SNRKSNRK 0.775 -0.100 2 0.687
PKCAPKCA 0.775 -0.023 2 0.686
PKCGPKCG 0.774 -0.025 2 0.695
PKCBPKCB 0.774 -0.025 2 0.694
MNK1MNK1 0.774 -0.014 -2 0.825
PHKG1PHKG1 0.774 -0.057 -3 0.876
PKACAPKACA 0.774 0.078 -2 0.657
DRAK1DRAK1 0.774 -0.002 1 0.799
VRK2VRK2 0.774 -0.180 1 0.890
BRAFBRAF 0.774 -0.008 -4 0.847
TLK2TLK2 0.773 0.001 1 0.839
MLK2MLK2 0.772 -0.177 2 0.794
DCAMKL2DCAMKL2 0.772 0.026 -3 0.881
PKCHPKCH 0.772 -0.034 2 0.687
NEK2NEK2 0.771 -0.057 2 0.776
SMMLCKSMMLCK 0.771 0.017 -3 0.882
BMPR1ABMPR1A 0.771 0.074 1 0.780
PLK4PLK4 0.771 -0.027 2 0.653
WNK4WNK4 0.771 -0.058 -2 0.880
AKT1AKT1 0.770 0.055 -3 0.800
DYRK1ADYRK1A 0.770 0.028 1 0.743
CDK7CDK7 0.770 -0.039 1 0.669
P70S6KP70S6K 0.770 0.038 -3 0.800
YSK4YSK4 0.769 -0.096 1 0.818
P38AP38A 0.769 -0.005 1 0.687
MLK3MLK3 0.769 -0.108 2 0.697
CDK19CDK19 0.768 -0.031 1 0.621
CDK5CDK5 0.767 -0.051 1 0.681
PHKG2PHKG2 0.767 -0.029 -3 0.875
PKCZPKCZ 0.767 -0.082 2 0.749
HRIHRI 0.767 -0.129 -2 0.893
CDK2CDK2 0.767 -0.072 1 0.706
GRK2GRK2 0.766 -0.010 -2 0.705
CAMK1ACAMK1A 0.766 0.073 -3 0.765
CDK1CDK1 0.766 -0.036 1 0.623
HIPK1HIPK1 0.765 0.014 1 0.723
MLK4MLK4 0.765 -0.116 2 0.690
PLK2PLK2 0.765 0.098 -3 0.803
PASKPASK 0.765 0.021 -3 0.875
DYRK4DYRK4 0.764 0.031 1 0.621
P38BP38B 0.764 0.011 1 0.611
PAK5PAK5 0.764 0.027 -2 0.667
CHAK1CHAK1 0.764 -0.174 2 0.751
CDK13CDK13 0.764 -0.051 1 0.643
PERKPERK 0.764 -0.110 -2 0.873
TLK1TLK1 0.764 -0.046 -2 0.841
SGK1SGK1 0.764 0.099 -3 0.718
HIPK2HIPK2 0.764 0.018 1 0.618
MEKK3MEKK3 0.763 -0.105 1 0.837
IRAK4IRAK4 0.763 -0.123 1 0.828
DAPK3DAPK3 0.763 0.042 -3 0.870
HIPK3HIPK3 0.763 -0.011 1 0.727
DYRK3DYRK3 0.762 0.031 1 0.732
CDK3CDK3 0.762 -0.027 1 0.555
PKCTPKCT 0.762 -0.036 2 0.700
CHK2CHK2 0.761 0.044 -3 0.749
PAK4PAK4 0.761 0.019 -2 0.671
P38GP38G 0.761 0.010 1 0.533
DYRK1BDYRK1B 0.761 0.027 1 0.645
IRAK1IRAK1 0.760 -0.151 -1 0.764
DAPK1DAPK1 0.760 0.049 -3 0.857
MEK5MEK5 0.760 -0.199 2 0.809
SBKSBK 0.760 0.103 -3 0.692
ERK2ERK2 0.760 -0.031 1 0.665
MEKK1MEKK1 0.760 -0.173 1 0.847
TTBK1TTBK1 0.760 -0.042 2 0.629
CDK9CDK9 0.759 -0.054 1 0.650
JNK1JNK1 0.759 0.028 1 0.600
PINK1PINK1 0.759 -0.147 1 0.839
CDK12CDK12 0.759 -0.042 1 0.618
PRP4PRP4 0.759 -0.041 -3 0.734
MEKK2MEKK2 0.759 -0.138 2 0.790
PKN1PKN1 0.758 0.011 -3 0.815
MRCKBMRCKB 0.758 0.059 -3 0.830
ERK1ERK1 0.758 -0.021 1 0.609
MST3MST3 0.757 -0.082 2 0.791
MRCKAMRCKA 0.757 0.057 -3 0.839
NEK5NEK5 0.757 -0.162 1 0.853
ZAKZAK 0.757 -0.143 1 0.823
CDK18CDK18 0.756 -0.039 1 0.591
AKT3AKT3 0.756 0.053 -3 0.728
GSK3BGSK3B 0.756 -0.024 4 0.420
CDK14CDK14 0.756 -0.027 1 0.642
TAO3TAO3 0.755 -0.088 1 0.829
P38DP38D 0.755 0.019 1 0.551
GRK3GRK3 0.755 0.022 -2 0.650
PDK1PDK1 0.755 -0.039 1 0.842
GSK3AGSK3A 0.755 0.021 4 0.432
PKCIPKCI 0.755 -0.059 2 0.708
CAMKK1CAMKK1 0.754 -0.087 -2 0.802
PDHK3_TYRPDHK3_TYR 0.754 0.181 4 0.914
CK1ECK1E 0.754 -0.050 -3 0.518
PKCEPKCE 0.754 -0.015 2 0.679
TAO2TAO2 0.754 -0.101 2 0.822
GAKGAK 0.754 -0.019 1 0.833
ROCK2ROCK2 0.754 0.053 -3 0.854
MPSK1MPSK1 0.753 -0.063 1 0.795
CDK17CDK17 0.752 -0.042 1 0.537
NEK11NEK11 0.750 -0.152 1 0.839
EEF2KEEF2K 0.750 -0.082 3 0.134
NEK8NEK8 0.750 -0.162 2 0.793
DMPK1DMPK1 0.750 0.065 -3 0.848
LKB1LKB1 0.750 -0.098 -3 0.808
CDK10CDK10 0.749 -0.023 1 0.627
CAMKK2CAMKK2 0.749 -0.082 -2 0.799
NEK4NEK4 0.748 -0.141 1 0.834
VRK1VRK1 0.748 -0.118 2 0.864
CK1G1CK1G1 0.748 -0.064 -3 0.519
GCKGCK 0.748 -0.080 1 0.843
RIPK2RIPK2 0.748 -0.149 1 0.791
TNIKTNIK 0.748 -0.082 3 0.104
CDK16CDK16 0.747 -0.024 1 0.557
BUB1BUB1 0.747 0.005 -5 0.847
TAK1TAK1 0.747 -0.067 1 0.875
PKG1PKG1 0.747 0.024 -2 0.642
HGKHGK 0.746 -0.115 3 0.094
CK1A2CK1A2 0.746 -0.047 -3 0.472
CK1DCK1D 0.746 -0.046 -3 0.466
MINKMINK 0.745 -0.106 1 0.840
PDHK4_TYRPDHK4_TYR 0.744 0.111 2 0.872
HPK1HPK1 0.744 -0.070 1 0.836
MAP2K4_TYRMAP2K4_TYR 0.743 0.021 -1 0.892
NEK1NEK1 0.743 -0.133 1 0.834
CRIKCRIK 0.743 0.062 -3 0.790
LOKLOK 0.743 -0.086 -2 0.811
TESK1_TYRTESK1_TYR 0.743 -0.047 3 0.162
MAP2K6_TYRMAP2K6_TYR 0.743 0.055 -1 0.883
MAP2K7_TYRMAP2K7_TYR 0.743 0.050 2 0.854
LRRK2LRRK2 0.743 -0.142 2 0.821
MOKMOK 0.742 0.028 1 0.727
MAP3K15MAP3K15 0.742 -0.141 1 0.807
ROCK1ROCK1 0.742 0.039 -3 0.838
MEKK6MEKK6 0.742 -0.160 1 0.815
KHS1KHS1 0.742 -0.066 1 0.832
MAKMAK 0.742 0.035 -2 0.750
CDK4CDK4 0.742 -0.041 1 0.605
MST2MST2 0.741 -0.113 1 0.842
KHS2KHS2 0.741 -0.056 1 0.844
PKMYT1_TYRPKMYT1_TYR 0.740 -0.103 3 0.130
BMPR2_TYRBMPR2_TYR 0.740 0.012 -1 0.884
ERK7ERK7 0.740 -0.048 2 0.479
CDK6CDK6 0.740 -0.058 1 0.621
PDHK1_TYRPDHK1_TYR 0.739 0.041 -1 0.894
MEK2MEK2 0.738 -0.157 2 0.806
MST1MST1 0.737 -0.110 1 0.829
LIMK2_TYRLIMK2_TYR 0.737 -0.062 -3 0.889
EPHA6EPHA6 0.737 -0.043 -1 0.892
RETRET 0.737 -0.077 1 0.837
PINK1_TYRPINK1_TYR 0.736 -0.099 1 0.861
YSK1YSK1 0.736 -0.115 2 0.769
STK33STK33 0.735 -0.131 2 0.611
PBKPBK 0.735 -0.049 1 0.737
SLKSLK 0.734 -0.096 -2 0.741
EPHB4EPHB4 0.734 -0.078 -1 0.883
INSRRINSRR 0.733 -0.092 3 0.085
ROS1ROS1 0.733 -0.175 3 0.064
DDR1DDR1 0.733 -0.075 4 0.840
TYRO3TYRO3 0.732 -0.164 3 0.078
MST1RMST1R 0.732 -0.175 3 0.079
TYK2TYK2 0.732 -0.158 1 0.834
TTKTTK 0.732 -0.077 -2 0.854
ALPHAK3ALPHAK3 0.731 -0.006 -1 0.785
YES1YES1 0.731 -0.060 -1 0.874
TXKTXK 0.730 -0.023 1 0.831
LIMK1_TYRLIMK1_TYR 0.730 -0.148 2 0.846
CSF1RCSF1R 0.730 -0.155 3 0.073
JAK2JAK2 0.730 -0.172 1 0.831
NEK3NEK3 0.730 -0.167 1 0.797
ABL2ABL2 0.729 -0.112 -1 0.850
FERFER 0.728 -0.099 1 0.860
EPHB1EPHB1 0.728 -0.085 1 0.842
SRMSSRMS 0.727 -0.062 1 0.849
EPHA4EPHA4 0.727 -0.041 2 0.783
BIKEBIKE 0.726 -0.025 1 0.697
EPHB3EPHB3 0.726 -0.081 -1 0.876
TNK2TNK2 0.726 -0.132 3 0.063
HCKHCK 0.726 -0.112 -1 0.864
EPHB2EPHB2 0.725 -0.066 -1 0.866
AXLAXL 0.725 -0.109 3 0.083
FGFR2FGFR2 0.725 -0.117 3 0.103
TEKTEK 0.725 -0.147 3 0.068
HASPINHASPIN 0.725 -0.062 -1 0.678
ALKALK 0.724 -0.131 3 0.066
MERTKMERTK 0.724 -0.085 3 0.094
ABL1ABL1 0.723 -0.129 -1 0.846
ASK1ASK1 0.723 -0.113 1 0.798
YANK3YANK3 0.723 -0.056 2 0.414
JAK3JAK3 0.723 -0.152 1 0.817
FGFR1FGFR1 0.723 -0.135 3 0.091
ITKITK 0.722 -0.107 -1 0.838
NEK10_TYRNEK10_TYR 0.722 -0.042 1 0.746
TNK1TNK1 0.722 -0.120 3 0.079
FLT3FLT3 0.722 -0.155 3 0.071
FGRFGR 0.722 -0.148 1 0.838
LCKLCK 0.722 -0.102 -1 0.862
BLKBLK 0.721 -0.078 -1 0.869
OSR1OSR1 0.721 -0.134 2 0.771
KDRKDR 0.721 -0.148 3 0.069
LTKLTK 0.721 -0.115 3 0.072
KITKIT 0.721 -0.150 3 0.079
TAO1TAO1 0.721 -0.119 1 0.773
TECTEC 0.721 -0.075 -1 0.810
MYO3BMYO3B 0.720 -0.132 2 0.785
PDGFRBPDGFRB 0.720 -0.185 3 0.079
DDR2DDR2 0.719 -0.062 3 0.072
JAK1JAK1 0.719 -0.133 1 0.787
BMXBMX 0.719 -0.074 -1 0.780
EPHA7EPHA7 0.719 -0.079 2 0.784
FYNFYN 0.719 -0.034 -1 0.840
MYO3AMYO3A 0.718 -0.136 1 0.829
PTK2BPTK2B 0.716 -0.064 -1 0.836
LYNLYN 0.716 -0.108 3 0.066
INSRINSR 0.716 -0.136 3 0.066
NTRK1NTRK1 0.715 -0.143 -1 0.847
EPHA3EPHA3 0.715 -0.097 2 0.759
TNNI3K_TYRTNNI3K_TYR 0.715 -0.104 1 0.830
EPHA1EPHA1 0.715 -0.134 3 0.061
BTKBTK 0.715 -0.157 -1 0.815
PDGFRAPDGFRA 0.714 -0.210 3 0.071
FGFR3FGFR3 0.714 -0.124 3 0.097
METMET 0.714 -0.153 3 0.075
FRKFRK 0.713 -0.122 -1 0.880
WEE1_TYRWEE1_TYR 0.713 -0.102 -1 0.782
NTRK2NTRK2 0.712 -0.174 3 0.079
PTK6PTK6 0.712 -0.101 -1 0.770
ERBB2ERBB2 0.712 -0.133 1 0.781
FLT4FLT4 0.712 -0.155 3 0.080
EPHA5EPHA5 0.711 -0.075 2 0.775
STLK3STLK3 0.711 -0.097 1 0.795
SRCSRC 0.709 -0.083 -1 0.846
FLT1FLT1 0.708 -0.116 -1 0.839
AAK1AAK1 0.708 -0.008 1 0.581
NTRK3NTRK3 0.707 -0.134 -1 0.806
EPHA8EPHA8 0.706 -0.100 -1 0.854
CK1ACK1A 0.706 -0.064 -3 0.375
IGF1RIGF1R 0.706 -0.114 3 0.065
CSKCSK 0.705 -0.104 2 0.787
EGFREGFR 0.705 -0.035 1 0.688
FGFR4FGFR4 0.702 -0.083 -1 0.798
EPHA2EPHA2 0.699 -0.098 -1 0.816
MATKMATK 0.699 -0.127 -1 0.767
PTK2PTK2 0.699 -0.034 -1 0.798
ERBB4ERBB4 0.695 -0.079 1 0.700
CK1G3CK1G3 0.694 -0.051 -3 0.330
SYKSYK 0.693 -0.037 -1 0.789
FESFES 0.691 -0.111 -1 0.760
MUSKMUSK 0.690 -0.150 1 0.669
YANK2YANK2 0.685 -0.086 2 0.428
CK1G2CK1G2 0.670 -0.096 -3 0.431
ZAP70ZAP70 0.665 -0.101 -1 0.720