Motif 719 (n=177)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J203 | None | S776 | ochoa | receptor protein-tyrosine kinase (EC 2.7.10.1) | None |
| A8MTJ3 | GNAT3 | S47 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction (PubMed:38600377, PubMed:38776963). Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs such as TAS2R14 act as bitter sensors (PubMed:38600377, PubMed:38776963). Also functions as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. {ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:17724330, ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}. |
| B0I1T2 | MYO1G | S583 | ochoa | Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}. |
| O00151 | PDLIM1 | S215 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O14686 | KMT2D | S2970 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S3229 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15539 | RGS5 | S84 | psp | Regulator of G-protein signaling 5 (RGS5) | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). {ECO:0000250}. |
| O43318 | MAP3K7 | S375 | ochoa | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}. |
| O60218 | AKR1B10 | S118 | ochoa | Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:18087047, ECO:0000269|PubMed:19013440, ECO:0000269|PubMed:19563777, ECO:0000269|PubMed:9565553}. |
| O60271 | SPAG9 | S183 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60732 | MAGEC1 | S1063 | ochoa | Melanoma-associated antigen C1 (Cancer/testis antigen 7.1) (CT7.1) (MAGE-C1 antigen) | None |
| O75044 | SRGAP2 | S487 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75369 | FLNB | S2531 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75449 | KATNA1 | S42 | psp | Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) | Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}. |
| O95218 | ZRANB2 | S65 | ochoa | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| O95235 | KIF20A | S49 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95235 | KIF20A | S433 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95239 | KIF4A | S548 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O96028 | NSD2 | S421 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P04899 | GNAI2 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P07237 | P4HB | S88 | ochoa | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P07237 | P4HB | S281 | ochoa | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P08047 | SP1 | S728 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08754 | GNAI3 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
| P09471 | GNAO1 | S47 | ochoa | Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:29925951, PubMed:33408414). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase (By similarity). Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). {ECO:0000250|UniProtKB:P18872, ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:33408414}. |
| P0CG47 | UBB | S65 | ochoa|psp | Polyubiquitin-B [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}. |
| P0CG48 | UBC | S65 | ochoa | Polyubiquitin-C [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}. |
| P10412 | H1-4 | S102 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10645 | CHGA | S113 | ochoa|psp | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P11488 | GNAT1 | S43 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) | Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). {ECO:0000250|UniProtKB:P04695, ECO:0000269|PubMed:22190596}. |
| P11498 | PC | S20 | ochoa | Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB) | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. {ECO:0000269|PubMed:9585002}. |
| P12268 | IMPDH2 | S426 | ochoa | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}. |
| P12814 | ACTN1 | S356 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P16234 | PDGFRA | S1016 | ochoa | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| P16401 | H1-5 | S105 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S103 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S102 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P18206 | VCL | S97 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P19087 | GNAT2 | S47 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. |
| P21333 | FLNA | S2576 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P22492 | H1-6 | S106 | ochoa | Histone H1t (Testicular H1 histone) | Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable). {ECO:0000269|PubMed:26757249, ECO:0000305}. |
| P25440 | BRD2 | S749 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P27348 | YWHAQ | S45 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P30622 | CLIP1 | S1303 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P31327 | CPS1 | S848 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P31946 | YWHAB | S47 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31947 | SFN | S45 | ochoa | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P32248 | CCR7 | S356 | psp | C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197) | Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. |
| P35462 | DRD3 | S233 | psp | D(3) dopamine receptor (Dopamine D3 receptor) | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. {ECO:0000269|PubMed:19520868}. |
| P38398 | BRCA1 | S425 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P38398 | BRCA1 | S1423 | psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P38405 | GNAL | S56 | ochoa | Guanine nucleotide-binding protein G(olf) subunit alpha (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein, olfactory type) | Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs) (By similarity). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (By similarity). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (By similarity). {ECO:0000250|UniProtKB:P38406, ECO:0000250|UniProtKB:Q8CGK7}. |
| P43034 | PAFAH1B1 | S81 | ochoa | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). {ECO:0000250|UniProtKB:P43033, ECO:0000250|UniProtKB:P63005, ECO:0000269|PubMed:15173193, ECO:0000269|PubMed:22956769}. |
| P47712 | PLA2G4A | S505 | psp | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| P49327 | FASN | S63 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49757 | NUMB | S303 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P50148 | GNAQ | S53 | psp | Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:37991948). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:37991948). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:37991948). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:37991948). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:37991948). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNAQ activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:37991948). Required for platelet activation (By similarity). Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity (By similarity). Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNA11, required for heart development (By similarity). {ECO:0000250|UniProtKB:P21279, ECO:0000269|PubMed:27852822, ECO:0000269|PubMed:37991948}. |
| P52789 | HK2 | S415 | ochoa | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
| P53350 | PLK1 | S99 | psp | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P56270 | MAZ | S361 | ochoa | Myc-associated zinc finger protein (MAZI) (Pur-1) (Purine-binding transcription factor) (Serum amyloid A-activating factor-1) (SAF-1) (Transcription factor Zif87) (ZF87) (Zinc finger protein 801) | Transcriptional regulator, potentially with dual roles in transcription initiation and termination. {ECO:0000303|PubMed:1502157}.; FUNCTION: [Isoform 1]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157). Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157). {ECO:0000269|PubMed:12270922, ECO:0000269|PubMed:1502157}.; FUNCTION: [Isoform 2]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922). {ECO:0000269|PubMed:12270922}.; FUNCTION: [Isoform 3]: Binds DNA and functions as a transcriptional activator. {ECO:0000269|PubMed:19583771}. |
| P61247 | RPS3A | S237 | ochoa | Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P61604 | HSPE1 | S51 | ochoa | 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1) | Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131, PubMed:7912672). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}. |
| P61981 | YWHAG | S46 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62258 | YWHAE | S46 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P62266 | RPS23 | S45 | ochoa | Small ribosomal subunit protein uS12 (40S ribosomal protein S23) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:28257692). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399, PubMed:25901680, PubMed:25957688). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399, PubMed:25901680, PubMed:25957688). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25901680, PubMed:25957688). Plays an important role in translational accuracy (PubMed:28257692). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:28257692, ECO:0000269|PubMed:34516797}. |
| P62491 | RAB11A | S115 | ochoa | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15601896, PubMed:15689490, PubMed:17462998, PubMed:19542231, PubMed:20026645, PubMed:20890297, PubMed:21282656, PubMed:26032412). The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization (PubMed:21282656). Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells (PubMed:17462998). Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane (PubMed:19542231). Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (PubMed:15689490). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). {ECO:0000250|UniProtKB:P62490, ECO:0000250|UniProtKB:P62492, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| P62937 | PPIA | S99 | ochoa | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}. |
| P62979 | RPS27A | S65 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P62987 | UBA52 | S65 | ochoa|psp | Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}. |
| P63096 | GNAI1 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883, PubMed:38918398). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:18434541, PubMed:8774883). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:18434541, PubMed:8774883). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:18434541, PubMed:8774883). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:8119955). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). {ECO:0000250|UniProtKB:P10824, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38552625, ECO:0000269|PubMed:38918398, ECO:0000269|PubMed:8119955, ECO:0000269|PubMed:8774883}. |
| P63104 | YWHAZ | S45 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| Q02241 | KIF23 | S303 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q02539 | H1-1 | S105 | ochoa | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q04917 | YWHAH | S46 | ochoa | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Q05D60 | DEUP1 | S518 | ochoa | Deuterosome assembly protein 1 (Coiled-coil domain-containing protein 67) | Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). {ECO:0000250}. |
| Q09666 | AHNAK | S5289 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13153 | PAK1 | S115 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13523 | PRP4K | S839 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13554 | CAMK2B | S276 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13555 | CAMK2G | S276 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13557 | CAMK2D | S276 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13615 | MTMR3 | S1173 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q14004 | CDK13 | S1022 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14444 | CAPRIN1 | S115 | ochoa | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}. |
| Q14980 | NUMA1 | S1103 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15059 | BRD3 | S681 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
| Q15149 | PLEC | S4365 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15181 | PPA1 | S30 | ochoa | Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) | None |
| Q15293 | RCN1 | S158 | ochoa | Reticulocalbin-1 | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. |
| Q15398 | DLGAP5 | S689 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15398 | DLGAP5 | S812 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15643 | TRIP11 | S601 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q15906 | VPS72 | S127 | ochoa | Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) | Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. {ECO:0000269|PubMed:26974126}. |
| Q15907 | RAB11B | S115 | ochoa | Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970, PubMed:26032412). The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). {ECO:0000269|PubMed:14627637, ECO:0000269|PubMed:19029296, ECO:0000269|PubMed:19244346, ECO:0000269|PubMed:20717956, ECO:0000269|PubMed:21248079, ECO:0000269|PubMed:22129970, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173}. |
| Q2LD37 | BLTP1 | S2603 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q56P03 | EAPP | S89 | ochoa | E2F-associated phosphoprotein (EAPP) | May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. {ECO:0000269|PubMed:15716352}. |
| Q5JWF2 | GNAS | S697 | ochoa | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas) | Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. {ECO:0000250|UniProtKB:Q6R0H7}. |
| Q5M7Z0 | RNFT1 | S76 | ochoa | E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1) | E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. {ECO:0000269|PubMed:27485036}. |
| Q5THJ4 | VPS13D | S2692 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5UIP0 | RIF1 | S978 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT06 | CEP350 | S2294 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VUB5 | FAM171A1 | S351 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VV41 | ARHGEF16 | S578 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
| Q6KC79 | NIPBL | S1197 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6L8Q7 | PDE12 | S438 | ochoa | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:26055709, PubMed:30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}. |
| Q6P0N0 | MIS18BP1 | S172 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6PJT7 | ZC3H14 | S365 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6WKZ4 | RAB11FIP1 | S384 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q86SQ0 | PHLDB2 | S965 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UU1 | PHLDB1 | S51 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q8N0Z3 | SPICE1 | S315 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8N6H7 | ARFGAP2 | S315 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8N7Z5 | ANKRD31 | S46 | ochoa | Ankyrin repeat domain-containing protein 31 | Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes. {ECO:0000250|UniProtKB:A0A140LI88}. |
| Q8NBU5 | ATAD1 | S317 | ochoa | Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase) | Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). {ECO:0000250|UniProtKB:P28737, ECO:0000250|UniProtKB:Q9D5T0, ECO:0000269|PubMed:24843043}. |
| Q8NEB9 | PIK3C3 | S282 | ochoa | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8NEF9 | SRFBP1 | S349 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8NEZ4 | KMT2C | S3786 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TAF3 | WDR48 | S335 | ochoa | WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) | Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029, PubMed:31253762). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27373336, PubMed:27650958). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27373336, PubMed:27650958). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27239033, PubMed:27463890, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:20147293). Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress (PubMed:31844045). {ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:24145035, ECO:0000269|PubMed:26388029, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:27650958, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31844045, ECO:0000269|PubMed:32350107}.; FUNCTION: (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488). {ECO:0000269|PubMed:12196293, ECO:0000269|PubMed:18032488}. |
| Q92925 | SMARCD2 | S203 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (PubMed:28369036). {ECO:0000269|PubMed:28369036, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q92974 | ARHGEF2 | S107 | ochoa | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q96AJ1 | CLUAP1 | S314 | ochoa | Clusterin-associated protein 1 (Qilin) | Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. {ECO:0000250|UniProtKB:Q8R3P7}. |
| Q96C24 | SYTL4 | S204 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96D71 | REPS1 | S740 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96K58 | ZNF668 | S568 | ochoa | Zinc finger protein 668 | May be involved in transcriptional regulation. May play a role in DNA repair process. {ECO:0000269|PubMed:34313816}. |
| Q96RL7 | VPS13A | S1416 | ochoa | Intermembrane lipid transfer protein VPS13A (Chorea-acanthocytosis protein) (Chorein) (Vacuolar protein sorting-associated protein 13A) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids (PubMed:34830155). Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (PubMed:30741634). Negatively regulates lipid droplet size and motility (PubMed:30741634). Required for efficient lysosomal protein degradation (PubMed:30709847). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:30709847, ECO:0000269|PubMed:30741634, ECO:0000269|PubMed:34830155}. |
| Q96SU4 | OSBPL9 | S348 | ochoa | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}. |
| Q9BPX5 | ARPC5L | S91 | ochoa | Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) | May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. |
| Q9BPZ7 | MAPKAP1 | S315 | psp | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BRS8 | LARP6 | S407 | ochoa | La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}. |
| Q9BY77 | POLDIP3 | S217 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9C0D7 | ZC3H12C | S752 | ochoa | Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) | May function as RNase and regulate the levels of target RNA species. {ECO:0000305}. |
| Q9H1A4 | ANAPC1 | S46 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H1J1 | UPF3A | S339 | ochoa | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}. |
| Q9NS56 | TOPORS | S577 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NVI1 | FANCI | S1111 | ochoa | Fanconi anemia group I protein (Protein FACI) | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}. |
| Q9NVP1 | DDX18 | S74 | ochoa | ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) | ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (PubMed:35858569). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (By similarity). {ECO:0000250|UniProtKB:Q8K363, ECO:0000269|PubMed:35858569}. |
| Q9NVV4 | MTPAP | S493 | ochoa | Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP) | Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. {ECO:0000269|PubMed:15547249, ECO:0000269|PubMed:15769737, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20970105, ECO:0000269|PubMed:21292163}. |
| Q9P1Y6 | PHRF1 | S430 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P2F8 | SIPA1L2 | S300 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UHB7 | AFF4 | S314 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UJ70 | NAGK | S74 | ochoa | N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60) | Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:22692205). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575). {ECO:0000250|UniProtKB:Q9QZ08, ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:36002575}. |
| Q9UMS6 | SYNPO2 | S212 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9Y250 | LZTS1 | S50 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
| Q9Y250 | LZTS1 | S180 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
| Q9Y252 | RNF6 | S85 | ochoa | E3 ubiquitin-protein ligase RNF6 (EC 2.3.2.27) | E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation (By similarity). Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover (By similarity). Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity (PubMed:19345326). May also bind DNA and function as a transcriptional regulator (By similarity). Mediates polyubiquitination of QKI in macrophages, leading to its degradation (By similarity). {ECO:0000250|UniProtKB:Q9DBU5, ECO:0000269|PubMed:19345326}. |
| Q9Y266 | NUDC | S285 | ochoa | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
| Q9Y2C9 | TLR6 | S417 | ochoa | Toll-like receptor 6 (CD antigen CD286) | Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584). {ECO:0000269|PubMed:11441107, ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:20037584}. |
| Q9Y2H2 | INPP5F | S829 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| Q9Y485 | DMXL1 | S465 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4K3 | TRAF6 | S188 | ochoa | TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6) | E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:11057907, PubMed:18347055, PubMed:19465916, PubMed:19713527, PubMed:27746020, PubMed:31620128). Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (PubMed:19675569). Leads to the activation of NF-kappa-B and JUN (PubMed:16378096, PubMed:17135271, PubMed:17703191). Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes (PubMed:18093978, PubMed:18758450). Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed:12140561, PubMed:19825828, PubMed:8837778). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (By similarity). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by initiating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: TRAF6 catalyzes initial 'Lys-63'-linked-polyubiquitin chains that are then branched via 'Lys-48'-linked polyubiquitin by HUWE1 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Participates also in the TCR signaling by ubiquitinating LAT (PubMed:23514740, PubMed:25907557). {ECO:0000250|UniProtKB:P70196, ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:12140561, ECO:0000269|PubMed:16378096, ECO:0000269|PubMed:17135271, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:18093978, ECO:0000269|PubMed:18347055, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:19465916, ECO:0000269|PubMed:19675569, ECO:0000269|PubMed:19713527, ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:31620128, ECO:0000269|PubMed:8837778}. |
| Q9Y4P8 | WIPI2 | S388 | ochoa | WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (PubMed:28890335). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066). {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:30968111}.; FUNCTION: [Isoform 4]: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. {ECO:0000269|PubMed:24954904}. |
| Q9Y5K6 | CD2AP | S256 | ochoa | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y5K6 | CD2AP | S463 | ochoa | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y5Q9 | GTF3C3 | S51 | ochoa | General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. |
| Q9Y6R0 | NUMBL | S332 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| Q9Y6W6 | DUSP10 | S224 | psp | Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5) | Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. {ECO:0000269|PubMed:10391943, ECO:0000269|PubMed:10597297, ECO:0000269|PubMed:22375048}. |
| S4R3N1 | HSPE1-MOB4 | S51 | ochoa | 10 kDa heat shock protein, mitochondrial (10 kDa chaperonin) (Chaperonin 10) (MOB-like protein phocein) (Mob1 homolog 3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3) | Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. {ECO:0000256|ARBA:ARBA00046093}.; FUNCTION: Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000256|ARBA:ARBA00044741}. |
| P62906 | RPL10A | S64 | Sugiyama | Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| O95817 | BAG3 | S467 | Sugiyama | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P50395 | GDI2 | S396 | Sugiyama | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| Q14204 | DYNC1H1 | S1313 | Sugiyama | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q9BTE6 | AARSD1 | S184 | Sugiyama | Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1) | Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). {ECO:0000250}. |
| Q9H2G2 | SLK | S362 | Sugiyama | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| P05997 | COL5A2 | S1308 | Sugiyama | Collagen alpha-2(V) chain | Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). {ECO:0000250}. |
| P07332 | FES | S56 | Sugiyama | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}. |
| P62888 | RPL30 | S75 | Sugiyama | Large ribosomal subunit protein eL30 (60S ribosomal protein L30) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q04864 | REL | S272 | Sugiyama | Proto-oncogene c-Rel | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. |
| Q9UBU9 | NXF1 | S223 | Sugiyama | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}. |
| Q9BS26 | ERP44 | S353 | Sugiyama | Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) | Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652484). May have a role in the control of oxidative protein folding in the endoplasmic reticulum (PubMed:11847130, PubMed:14517240, PubMed:29858230). Required to retain ERO1A and ERO1B in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230). {ECO:0000269|PubMed:11847130, ECO:0000269|PubMed:14517240, ECO:0000269|PubMed:15652484, ECO:0000269|PubMed:29858230}. |
| O00469 | PLOD2 | S441 | Sugiyama | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2) | Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. {ECO:0000250|UniProtKB:P24802}. |
| Q14257 | RCN2 | S298 | Sugiyama | Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP) | Not known. Binds calcium. |
| P54762 | EPHB1 | S588 | Sugiyama | Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). {ECO:0000250|UniProtKB:Q8CBF3, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:12925710, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:9430661, ECO:0000269|PubMed:9499402}. |
| Q9Y5J9 | TIMM8B | S57 | Sugiyama | Mitochondrial import inner membrane translocase subunit Tim8 B (DDP-like protein) (Deafness dystonia protein 2) | Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). {ECO:0000250}. |
| Q53QZ3 | ARHGAP15 | S292 | PSP | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
| Q16512 | PKN1 | S296 | Sugiyama | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| Q9P0L2 | MARK1 | S486 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q5T0F9 | CC2D1B | S209 | Sugiyama | Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269|PubMed:19423080}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.724176e-13 | 12.763 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.224010e-11 | 10.374 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.357459e-11 | 10.361 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.384329e-10 | 9.859 |
| R-HSA-109581 | Apoptosis | 1.180426e-10 | 9.928 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.343995e-09 | 8.630 |
| R-HSA-69481 | G2/M Checkpoints | 3.166341e-09 | 8.499 |
| R-HSA-5357801 | Programmed Cell Death | 3.270069e-09 | 8.485 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 5.003041e-09 | 8.301 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 5.003041e-09 | 8.301 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.072547e-08 | 7.970 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.343753e-08 | 7.872 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.716439e-08 | 7.765 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.650798e-08 | 7.577 |
| R-HSA-112040 | G-protein mediated events | 3.806128e-08 | 7.420 |
| R-HSA-1640170 | Cell Cycle | 7.790083e-08 | 7.108 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 8.636717e-08 | 7.064 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.150301e-07 | 6.939 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.575222e-07 | 6.803 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.688815e-07 | 6.433 |
| R-HSA-68886 | M Phase | 5.939268e-07 | 6.226 |
| R-HSA-162582 | Signal Transduction | 5.928543e-07 | 6.227 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.983913e-07 | 6.223 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 6.734419e-07 | 6.172 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.056467e-07 | 6.094 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 9.659768e-07 | 6.015 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 9.642441e-07 | 6.016 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.197234e-06 | 5.922 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.122800e-07 | 6.147 |
| R-HSA-2559583 | Cellular Senescence | 1.221870e-06 | 5.913 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.350601e-06 | 5.869 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.846783e-06 | 5.734 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.846783e-06 | 5.734 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.846783e-06 | 5.734 |
| R-HSA-111885 | Opioid Signalling | 1.803290e-06 | 5.744 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 1.951806e-06 | 5.710 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.327000e-06 | 5.633 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.343653e-06 | 5.630 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.476319e-06 | 5.606 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 3.263411e-06 | 5.486 |
| R-HSA-9694493 | Maturation of protein E | 3.298331e-06 | 5.482 |
| R-HSA-9683683 | Maturation of protein E | 3.298331e-06 | 5.482 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.237043e-06 | 5.490 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.488790e-06 | 5.457 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.488790e-06 | 5.457 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 4.234728e-06 | 5.373 |
| R-HSA-193639 | p75NTR signals via NF-kB | 4.234728e-06 | 5.373 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 4.234728e-06 | 5.373 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.908187e-06 | 5.229 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 5.419469e-06 | 5.266 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 6.849416e-06 | 5.164 |
| R-HSA-199991 | Membrane Trafficking | 7.690723e-06 | 5.114 |
| R-HSA-8948747 | Regulation of PTEN localization | 7.901655e-06 | 5.102 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 7.984776e-06 | 5.098 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.984776e-06 | 5.098 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.946260e-06 | 5.048 |
| R-HSA-2262752 | Cellular responses to stress | 9.144948e-06 | 5.039 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.145995e-05 | 4.941 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 1.145995e-05 | 4.941 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.145995e-05 | 4.941 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.092677e-05 | 4.962 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 1.145995e-05 | 4.941 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.145995e-05 | 4.941 |
| R-HSA-392518 | Signal amplification | 1.276061e-05 | 4.894 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.276061e-05 | 4.894 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.296792e-05 | 4.887 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.296792e-05 | 4.887 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.557846e-05 | 4.807 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.671729e-05 | 4.777 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.891772e-05 | 4.723 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.897539e-05 | 4.722 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.082485e-05 | 4.681 |
| R-HSA-418594 | G alpha (i) signalling events | 2.167185e-05 | 4.664 |
| R-HSA-5689877 | Josephin domain DUBs | 2.193704e-05 | 4.659 |
| R-HSA-9664873 | Pexophagy | 2.193704e-05 | 4.659 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.269339e-05 | 4.644 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.354926e-05 | 4.628 |
| R-HSA-9679506 | SARS-CoV Infections | 2.723244e-05 | 4.565 |
| R-HSA-156902 | Peptide chain elongation | 2.866620e-05 | 4.543 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.922909e-05 | 4.534 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.276320e-05 | 4.485 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.547001e-05 | 4.450 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.801791e-05 | 4.420 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 3.815647e-05 | 4.418 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 3.815647e-05 | 4.418 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.732180e-05 | 4.428 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.432830e-05 | 4.464 |
| R-HSA-68882 | Mitotic Anaphase | 3.703869e-05 | 4.431 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 3.815647e-05 | 4.418 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.856160e-05 | 4.414 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 4.071693e-05 | 4.390 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.229559e-05 | 4.374 |
| R-HSA-69275 | G2/M Transition | 4.871149e-05 | 4.312 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 4.893104e-05 | 4.310 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 4.893104e-05 | 4.310 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 4.893104e-05 | 4.310 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 4.893104e-05 | 4.310 |
| R-HSA-5689901 | Metalloprotease DUBs | 5.053923e-05 | 4.296 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 5.053923e-05 | 4.296 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 5.282062e-05 | 4.277 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 5.282062e-05 | 4.277 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.316804e-05 | 4.274 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 6.177363e-05 | 4.209 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.316804e-05 | 4.274 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.399346e-05 | 4.268 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 5.837290e-05 | 4.234 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.308486e-05 | 4.275 |
| R-HSA-75153 | Apoptotic execution phase | 5.850338e-05 | 4.233 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.446041e-05 | 4.191 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.446041e-05 | 4.191 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.446041e-05 | 4.191 |
| R-HSA-422475 | Axon guidance | 6.801803e-05 | 4.167 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.864084e-05 | 4.163 |
| R-HSA-9634597 | GPER1 signaling | 7.133276e-05 | 4.147 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 7.691337e-05 | 4.114 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 7.691337e-05 | 4.114 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.767957e-05 | 4.110 |
| R-HSA-192823 | Viral mRNA Translation | 8.768489e-05 | 4.057 |
| R-HSA-110312 | Translesion synthesis by REV1 | 9.458713e-05 | 4.024 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 9.458713e-05 | 4.024 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 9.458713e-05 | 4.024 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 9.307457e-05 | 4.031 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 9.458713e-05 | 4.024 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 9.468751e-05 | 4.024 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 9.863440e-05 | 4.006 |
| R-HSA-162588 | Budding and maturation of HIV virion | 9.947459e-05 | 4.002 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 1.036962e-04 | 3.984 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.133731e-04 | 3.945 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.150390e-04 | 3.939 |
| R-HSA-9708530 | Regulation of BACH1 activity | 1.150390e-04 | 3.939 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.150390e-04 | 3.939 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 1.174568e-04 | 3.930 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.216472e-04 | 3.915 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.243132e-04 | 3.905 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.243132e-04 | 3.905 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.348740e-04 | 3.870 |
| R-HSA-418597 | G alpha (z) signalling events | 1.348740e-04 | 3.870 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.385195e-04 | 3.858 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 1.385195e-04 | 3.858 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.385195e-04 | 3.858 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.467718e-04 | 3.833 |
| R-HSA-9675108 | Nervous system development | 1.534999e-04 | 3.814 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.652856e-04 | 3.782 |
| R-HSA-3229121 | Glycogen storage diseases | 1.652856e-04 | 3.782 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.129551e-04 | 3.672 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.129551e-04 | 3.672 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.955993e-04 | 3.709 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.919916e-04 | 3.717 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.989166e-04 | 3.701 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.988428e-04 | 3.701 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.989166e-04 | 3.701 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.785672e-04 | 3.748 |
| R-HSA-450294 | MAP kinase activation | 2.193108e-04 | 3.659 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.955993e-04 | 3.709 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.209871e-04 | 3.656 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.209871e-04 | 3.656 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.297282e-04 | 3.639 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.297282e-04 | 3.639 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.367209e-04 | 3.626 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.367209e-04 | 3.626 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.478940e-04 | 3.606 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.478940e-04 | 3.606 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.679441e-04 | 3.572 |
| R-HSA-3322077 | Glycogen synthesis | 2.679441e-04 | 3.572 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.706732e-04 | 3.568 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.776215e-04 | 3.557 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.825019e-04 | 3.549 |
| R-HSA-73887 | Death Receptor Signaling | 2.846231e-04 | 3.546 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.873958e-04 | 3.542 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.873958e-04 | 3.542 |
| R-HSA-9646399 | Aggrephagy | 2.984856e-04 | 3.525 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.984856e-04 | 3.525 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 3.105231e-04 | 3.508 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 3.105231e-04 | 3.508 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 3.105231e-04 | 3.508 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 3.105231e-04 | 3.508 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.105231e-04 | 3.508 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.105231e-04 | 3.508 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.284122e-04 | 3.484 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.284122e-04 | 3.484 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.483406e-04 | 3.458 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.577449e-04 | 3.446 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.577449e-04 | 3.446 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 3.577449e-04 | 3.446 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.605568e-04 | 3.443 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.605568e-04 | 3.443 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.682751e-04 | 3.434 |
| R-HSA-991365 | Activation of GABAB receptors | 3.950250e-04 | 3.403 |
| R-HSA-977444 | GABA B receptor activation | 3.950250e-04 | 3.403 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.950250e-04 | 3.403 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 4.098925e-04 | 3.387 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 4.098925e-04 | 3.387 |
| R-HSA-448424 | Interleukin-17 signaling | 4.185136e-04 | 3.378 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.583155e-04 | 3.253 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 5.583155e-04 | 3.253 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.583155e-04 | 3.253 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.583155e-04 | 3.253 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.472960e-04 | 3.349 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.472960e-04 | 3.349 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.583155e-04 | 3.253 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.573458e-04 | 3.340 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.134575e-04 | 3.289 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.820988e-04 | 3.317 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.775993e-04 | 3.321 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.573458e-04 | 3.340 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 5.702245e-04 | 3.244 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.794687e-04 | 3.237 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.060539e-04 | 3.217 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.189143e-04 | 3.208 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.223739e-04 | 3.206 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 6.734890e-04 | 3.172 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 6.734890e-04 | 3.172 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.742144e-04 | 3.171 |
| R-HSA-73893 | DNA Damage Bypass | 7.106393e-04 | 3.148 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.209603e-04 | 3.142 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 7.545941e-04 | 3.122 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 7.545941e-04 | 3.122 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.564362e-04 | 3.121 |
| R-HSA-1632852 | Macroautophagy | 7.623445e-04 | 3.118 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.932796e-04 | 3.101 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.932796e-04 | 3.101 |
| R-HSA-202403 | TCR signaling | 7.932796e-04 | 3.101 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 8.281646e-04 | 3.082 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 8.423681e-04 | 3.074 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 8.423681e-04 | 3.074 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 8.768775e-04 | 3.057 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 8.920833e-04 | 3.050 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 8.920833e-04 | 3.050 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 9.123887e-04 | 3.040 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 9.371056e-04 | 3.028 |
| R-HSA-9615710 | Late endosomal microautophagy | 9.371056e-04 | 3.028 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 9.371056e-04 | 3.028 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 9.371056e-04 | 3.028 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 9.371056e-04 | 3.028 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 9.550786e-04 | 3.020 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 9.596039e-04 | 3.018 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 1.030852e-03 | 2.987 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.036302e-03 | 2.985 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.039102e-03 | 2.983 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.043398e-03 | 2.982 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.045173e-03 | 2.981 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.094106e-03 | 2.961 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.094106e-03 | 2.961 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.105952e-03 | 2.956 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.148651e-03 | 2.940 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.148651e-03 | 2.940 |
| R-HSA-182971 | EGFR downregulation | 1.148651e-03 | 2.940 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 1.148651e-03 | 2.940 |
| R-HSA-75893 | TNF signaling | 1.185034e-03 | 2.926 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.185034e-03 | 2.926 |
| R-HSA-68877 | Mitotic Prometaphase | 1.239798e-03 | 2.907 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.860951e-03 | 2.730 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.860951e-03 | 2.730 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.282443e-03 | 2.892 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.421129e-03 | 2.847 |
| R-HSA-5673000 | RAF activation | 1.668266e-03 | 2.778 |
| R-HSA-5696400 | Dual Incision in GG-NER | 1.668266e-03 | 2.778 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.819986e-03 | 2.740 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.819986e-03 | 2.740 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 1.525563e-03 | 2.817 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.257487e-03 | 2.900 |
| R-HSA-5693538 | Homology Directed Repair | 1.245346e-03 | 2.905 |
| R-HSA-388396 | GPCR downstream signalling | 1.710902e-03 | 2.767 |
| R-HSA-977443 | GABA receptor activation | 1.543745e-03 | 2.811 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.525563e-03 | 2.817 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.668266e-03 | 2.778 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.668266e-03 | 2.778 |
| R-HSA-169911 | Regulation of Apoptosis | 1.819986e-03 | 2.740 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.509895e-03 | 2.821 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.796812e-03 | 2.745 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 1.391588e-03 | 2.856 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.668266e-03 | 2.778 |
| R-HSA-9612973 | Autophagy | 1.401860e-03 | 2.853 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.268224e-03 | 2.897 |
| R-HSA-112043 | PLC beta mediated events | 1.644672e-03 | 2.784 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.750363e-03 | 2.757 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.266049e-03 | 2.898 |
| R-HSA-202424 | Downstream TCR signaling | 1.421129e-03 | 2.847 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.668266e-03 | 2.778 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.391588e-03 | 2.856 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.732550e-03 | 2.761 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 1.668266e-03 | 2.778 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.352343e-03 | 2.869 |
| R-HSA-9711097 | Cellular response to starvation | 1.505216e-03 | 2.822 |
| R-HSA-1980145 | Signaling by NOTCH2 | 1.668266e-03 | 2.778 |
| R-HSA-9824446 | Viral Infection Pathways | 1.584133e-03 | 2.800 |
| R-HSA-5663205 | Infectious disease | 1.438793e-03 | 2.842 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.668266e-03 | 2.778 |
| R-HSA-2408522 | Selenoamino acid metabolism | 1.852008e-03 | 2.732 |
| R-HSA-5205647 | Mitophagy | 1.668266e-03 | 2.778 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.892086e-03 | 2.723 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.906443e-03 | 2.720 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.981013e-03 | 2.703 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.981013e-03 | 2.703 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.097353e-03 | 2.678 |
| R-HSA-4641258 | Degradation of DVL | 2.151634e-03 | 2.667 |
| R-HSA-4641257 | Degradation of AXIN | 2.151634e-03 | 2.667 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.151634e-03 | 2.667 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.161371e-03 | 2.665 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.223436e-03 | 2.653 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 2.332134e-03 | 2.632 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.333255e-03 | 2.632 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.354954e-03 | 2.628 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.362838e-03 | 2.627 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.427163e-03 | 2.615 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.487361e-03 | 2.604 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.522796e-03 | 2.598 |
| R-HSA-69541 | Stabilization of p53 | 2.522796e-03 | 2.598 |
| R-HSA-9648002 | RAS processing | 2.522796e-03 | 2.598 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.522796e-03 | 2.598 |
| R-HSA-212436 | Generic Transcription Pathway | 2.540895e-03 | 2.595 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.567347e-03 | 2.591 |
| R-HSA-1280218 | Adaptive Immune System | 2.632583e-03 | 2.580 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.723901e-03 | 2.565 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.723901e-03 | 2.565 |
| R-HSA-8982491 | Glycogen metabolism | 2.723901e-03 | 2.565 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.737140e-03 | 2.563 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.783467e-03 | 2.555 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.798837e-03 | 2.553 |
| R-HSA-163685 | Integration of energy metabolism | 2.836008e-03 | 2.547 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.836008e-03 | 2.547 |
| R-HSA-1500931 | Cell-Cell communication | 2.869975e-03 | 2.542 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.935725e-03 | 2.532 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.935725e-03 | 2.532 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.935725e-03 | 2.532 |
| R-HSA-9607240 | FLT3 Signaling | 2.935725e-03 | 2.532 |
| R-HSA-5632684 | Hedgehog 'on' state | 2.938078e-03 | 2.532 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.938078e-03 | 2.532 |
| R-HSA-168255 | Influenza Infection | 3.090481e-03 | 2.510 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.158544e-03 | 2.501 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 3.158544e-03 | 2.501 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.158544e-03 | 2.501 |
| R-HSA-9683701 | Translation of Structural Proteins | 3.158544e-03 | 2.501 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.265774e-03 | 2.486 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.265774e-03 | 2.486 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.340737e-03 | 2.476 |
| R-HSA-111996 | Ca-dependent events | 3.392629e-03 | 2.469 |
| R-HSA-9013694 | Signaling by NOTCH4 | 3.439130e-03 | 2.464 |
| R-HSA-1643685 | Disease | 3.601592e-03 | 2.444 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.616680e-03 | 2.442 |
| R-HSA-8852135 | Protein ubiquitination | 3.619007e-03 | 2.441 |
| R-HSA-380287 | Centrosome maturation | 3.619007e-03 | 2.441 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.619007e-03 | 2.441 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.638250e-03 | 2.439 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 3.638250e-03 | 2.439 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.638250e-03 | 2.439 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 3.638250e-03 | 2.439 |
| R-HSA-446728 | Cell junction organization | 3.712058e-03 | 2.430 |
| R-HSA-1980143 | Signaling by NOTCH1 | 3.805538e-03 | 2.420 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.813608e-03 | 2.419 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.813608e-03 | 2.419 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.895670e-03 | 2.409 |
| R-HSA-69236 | G1 Phase | 3.895670e-03 | 2.409 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.895670e-03 | 2.409 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.026729e-03 | 2.395 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.165153e-03 | 2.380 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.165153e-03 | 2.380 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.165153e-03 | 2.380 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.165153e-03 | 2.380 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.165153e-03 | 2.380 |
| R-HSA-5617833 | Cilium Assembly | 4.261726e-03 | 2.370 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.446955e-03 | 2.352 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.446955e-03 | 2.352 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.446955e-03 | 2.352 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.446955e-03 | 2.352 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 4.513832e-03 | 2.345 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 4.513832e-03 | 2.345 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 4.513832e-03 | 2.345 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.620919e-03 | 2.335 |
| R-HSA-6806834 | Signaling by MET | 4.620919e-03 | 2.335 |
| R-HSA-157118 | Signaling by NOTCH | 4.766637e-03 | 2.322 |
| R-HSA-977225 | Amyloid fiber formation | 4.842748e-03 | 2.315 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.981932e-03 | 2.303 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.003245e-03 | 2.301 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.048533e-03 | 2.297 |
| R-HSA-372790 | Signaling by GPCR | 5.204134e-03 | 2.284 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 5.308921e-03 | 2.275 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.322864e-03 | 2.274 |
| R-HSA-9766229 | Degradation of CDH1 | 5.368805e-03 | 2.270 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 5.368805e-03 | 2.270 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5.368805e-03 | 2.270 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5.368805e-03 | 2.270 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.368805e-03 | 2.270 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.553529e-03 | 2.255 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.599293e-03 | 2.252 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.599293e-03 | 2.252 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 5.702390e-03 | 2.244 |
| R-HSA-195721 | Signaling by WNT | 5.789409e-03 | 2.237 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.805993e-03 | 2.236 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.007838e-03 | 2.221 |
| R-HSA-3371571 | HSF1-dependent transactivation | 6.049527e-03 | 2.218 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 6.049527e-03 | 2.218 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.066442e-03 | 2.217 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.335008e-03 | 2.198 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 6.410449e-03 | 2.193 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.410449e-03 | 2.193 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.410889e-03 | 2.193 |
| R-HSA-3371556 | Cellular response to heat stress | 6.410889e-03 | 2.193 |
| R-HSA-9620244 | Long-term potentiation | 6.595678e-03 | 2.181 |
| R-HSA-70268 | Pyruvate metabolism | 6.611817e-03 | 2.180 |
| R-HSA-5688426 | Deubiquitination | 6.778851e-03 | 2.169 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 6.785385e-03 | 2.168 |
| R-HSA-9663891 | Selective autophagy | 6.896999e-03 | 2.161 |
| R-HSA-72649 | Translation initiation complex formation | 7.174560e-03 | 2.144 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 7.174560e-03 | 2.144 |
| R-HSA-1236974 | ER-Phagosome pathway | 7.190680e-03 | 2.143 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.791004e-03 | 2.108 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 7.996503e-03 | 2.097 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 7.996503e-03 | 2.097 |
| R-HSA-177929 | Signaling by EGFR | 7.996503e-03 | 2.097 |
| R-HSA-5654736 | Signaling by FGFR1 | 7.996503e-03 | 2.097 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 8.087386e-03 | 2.092 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 8.087386e-03 | 2.092 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 1.203689e-02 | 1.919 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 1.203689e-02 | 1.919 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 1.203689e-02 | 1.919 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 1.203689e-02 | 1.919 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 1.203689e-02 | 1.919 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 1.203689e-02 | 1.919 |
| R-HSA-6782135 | Dual incision in TC-NER | 8.877983e-03 | 2.052 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 9.548906e-03 | 2.020 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 9.548906e-03 | 2.020 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 8.475695e-03 | 2.072 |
| R-HSA-9033241 | Peroxisomal protein import | 9.341561e-03 | 2.030 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 1.470288e-02 | 1.833 |
| R-HSA-422356 | Regulation of insulin secretion | 1.101728e-02 | 1.958 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 8.877983e-03 | 2.052 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.224387e-02 | 1.912 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.217140e-02 | 1.915 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.063968e-02 | 1.973 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.031537e-02 | 1.987 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.062206e-02 | 1.974 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.245481e-02 | 1.905 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.062206e-02 | 1.974 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.135265e-02 | 1.945 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.360101e-02 | 1.866 |
| R-HSA-111933 | Calmodulin induced events | 1.584752e-02 | 1.800 |
| R-HSA-74160 | Gene expression (Transcription) | 1.499338e-02 | 1.824 |
| R-HSA-111997 | CaM pathway | 1.584752e-02 | 1.800 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.279363e-02 | 1.893 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 9.820628e-03 | 2.008 |
| R-HSA-1227986 | Signaling by ERBB2 | 9.820628e-03 | 2.008 |
| R-HSA-8953854 | Metabolism of RNA | 8.341412e-03 | 2.079 |
| R-HSA-69239 | Synthesis of DNA | 1.553350e-02 | 1.809 |
| R-HSA-72312 | rRNA processing | 1.234772e-02 | 1.908 |
| R-HSA-8983711 | OAS antiviral response | 1.644895e-02 | 1.784 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.360101e-02 | 1.866 |
| R-HSA-5218859 | Regulated Necrosis | 1.423265e-02 | 1.847 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.550275e-02 | 1.810 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.224387e-02 | 1.912 |
| R-HSA-9833110 | RSV-host interactions | 1.406802e-02 | 1.852 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 9.421007e-03 | 2.026 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 9.421007e-03 | 2.026 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.550275e-02 | 1.810 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 9.820628e-03 | 2.008 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 9.820628e-03 | 2.008 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 9.820628e-03 | 2.008 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 9.820628e-03 | 2.008 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.604380e-02 | 1.795 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.224387e-02 | 1.912 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 8.452892e-03 | 2.073 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.553350e-02 | 1.809 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.553350e-02 | 1.809 |
| R-HSA-983712 | Ion channel transport | 1.407666e-02 | 1.852 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.142244e-02 | 1.942 |
| R-HSA-8848021 | Signaling by PTK6 | 1.135265e-02 | 1.945 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.135265e-02 | 1.945 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.655905e-02 | 1.781 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.684210e-02 | 1.774 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 1.753808e-02 | 1.756 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.770285e-02 | 1.752 |
| R-HSA-73894 | DNA Repair | 1.824604e-02 | 1.739 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.825175e-02 | 1.739 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.842389e-02 | 1.735 |
| R-HSA-9609507 | Protein localization | 1.863182e-02 | 1.730 |
| R-HSA-69306 | DNA Replication | 1.863182e-02 | 1.730 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.898325e-02 | 1.722 |
| R-HSA-917937 | Iron uptake and transport | 1.898325e-02 | 1.722 |
| R-HSA-109582 | Hemostasis | 1.910457e-02 | 1.719 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 1.933700e-02 | 1.714 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.934108e-02 | 1.714 |
| R-HSA-5689603 | UCH proteinases | 1.973268e-02 | 1.705 |
| R-HSA-5260271 | Diseases of Immune System | 1.998563e-02 | 1.699 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.998563e-02 | 1.699 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.050015e-02 | 1.688 |
| R-HSA-1266738 | Developmental Biology | 2.095843e-02 | 1.679 |
| R-HSA-5619084 | ABC transporter disorders | 2.128578e-02 | 1.672 |
| R-HSA-4086400 | PCP/CE pathway | 2.128578e-02 | 1.672 |
| R-HSA-72766 | Translation | 2.209900e-02 | 1.656 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.214505e-02 | 1.655 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.225671e-02 | 1.653 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.265538e-02 | 1.645 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.265538e-02 | 1.645 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.291185e-02 | 1.640 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.392963e-02 | 1.621 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.392963e-02 | 1.621 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.490690e-02 | 1.604 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.507429e-02 | 1.601 |
| R-HSA-913531 | Interferon Signaling | 2.637522e-02 | 1.579 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.638576e-02 | 1.579 |
| R-HSA-418990 | Adherens junctions interactions | 2.688061e-02 | 1.571 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.720344e-02 | 1.565 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 2.720356e-02 | 1.565 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.720356e-02 | 1.565 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.724565e-02 | 1.565 |
| R-HSA-418555 | G alpha (s) signalling events | 2.916045e-02 | 1.535 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.966923e-02 | 1.528 |
| R-HSA-2028269 | Signaling by Hippo | 2.966923e-02 | 1.528 |
| R-HSA-114608 | Platelet degranulation | 3.021675e-02 | 1.520 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 3.045661e-02 | 1.516 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 3.045661e-02 | 1.516 |
| R-HSA-3928664 | Ephrin signaling | 3.217529e-02 | 1.492 |
| R-HSA-164378 | PKA activation in glucagon signalling | 3.217529e-02 | 1.492 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.217529e-02 | 1.492 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 3.476150e-02 | 1.459 |
| R-HSA-392517 | Rap1 signalling | 3.476150e-02 | 1.459 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.597926e-02 | 1.444 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.622035e-02 | 1.441 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 3.638866e-02 | 1.439 |
| R-HSA-373753 | Nephrin family interactions | 3.742559e-02 | 1.427 |
| R-HSA-1474290 | Collagen formation | 3.861801e-02 | 1.413 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.923922e-02 | 1.406 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.048347e-02 | 1.393 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.190847e-02 | 1.378 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.210582e-02 | 1.376 |
| R-HSA-6807070 | PTEN Regulation | 4.237683e-02 | 1.373 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 4.297857e-02 | 1.367 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 4.297857e-02 | 1.367 |
| R-HSA-5578775 | Ion homeostasis | 4.355938e-02 | 1.361 |
| R-HSA-190236 | Signaling by FGFR | 4.452691e-02 | 1.351 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.632182e-02 | 1.334 |
| R-HSA-4839726 | Chromatin organization | 4.672912e-02 | 1.330 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.702463e-02 | 1.328 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 4.728950e-02 | 1.325 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.734115e-02 | 1.325 |
| R-HSA-421270 | Cell-cell junction organization | 4.826333e-02 | 1.316 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 4.830219e-02 | 1.316 |
| R-HSA-3000170 | Syndecan interactions | 4.881688e-02 | 1.311 |
| R-HSA-1483255 | PI Metabolism | 4.959885e-02 | 1.305 |
| R-HSA-983189 | Kinesins | 5.048234e-02 | 1.297 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 5.183780e-02 | 1.285 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 5.183780e-02 | 1.285 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 5.183780e-02 | 1.285 |
| R-HSA-445717 | Aquaporin-mediated transport | 5.229184e-02 | 1.282 |
| R-HSA-69242 | S Phase | 5.263691e-02 | 1.279 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.484827e-02 | 1.261 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 5.492385e-02 | 1.260 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.497591e-02 | 1.260 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.600374e-02 | 1.252 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.643372e-02 | 1.248 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.790563e-02 | 1.237 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 5.807304e-02 | 1.236 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 5.876000e-02 | 1.231 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 5.876000e-02 | 1.231 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 5.876000e-02 | 1.231 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 5.876000e-02 | 1.231 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.877496e-02 | 1.231 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.920756e-02 | 1.228 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 6.128342e-02 | 1.213 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.180004e-02 | 1.209 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.260108e-02 | 1.203 |
| R-HSA-162587 | HIV Life Cycle | 6.300672e-02 | 1.201 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.581345e-02 | 1.182 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.581345e-02 | 1.182 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.670207e-02 | 1.176 |
| R-HSA-420092 | Glucagon-type ligand receptors | 6.788014e-02 | 1.168 |
| R-HSA-205025 | NADE modulates death signalling | 7.009310e-02 | 1.154 |
| R-HSA-390651 | Dopamine receptors | 7.009310e-02 | 1.154 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 7.126277e-02 | 1.147 |
| R-HSA-909733 | Interferon alpha/beta signaling | 7.290938e-02 | 1.137 |
| R-HSA-9658195 | Leishmania infection | 7.515249e-02 | 1.124 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.515249e-02 | 1.124 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.615573e-02 | 1.118 |
| R-HSA-4086398 | Ca2+ pathway | 7.635259e-02 | 1.117 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.947390e-02 | 1.100 |
| R-HSA-71737 | Pyrophosphate hydrolysis | 8.129044e-02 | 1.090 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 8.129044e-02 | 1.090 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 8.172617e-02 | 1.088 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 8.172617e-02 | 1.088 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.286315e-02 | 1.082 |
| R-HSA-9020591 | Interleukin-12 signaling | 8.301067e-02 | 1.081 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 8.531336e-02 | 1.069 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.632268e-02 | 1.064 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 8.990922e-02 | 1.046 |
| R-HSA-69206 | G1/S Transition | 9.164187e-02 | 1.038 |
| R-HSA-164525 | Plus-strand DNA synthesis | 9.235362e-02 | 1.035 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 9.235362e-02 | 1.035 |
| R-HSA-9652817 | Signaling by MAPK mutants | 9.235362e-02 | 1.035 |
| R-HSA-176417 | Phosphorylation of Emi1 | 9.235362e-02 | 1.035 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 9.235362e-02 | 1.035 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 9.262678e-02 | 1.033 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 9.262678e-02 | 1.033 |
| R-HSA-8939211 | ESR-mediated signaling | 9.399647e-02 | 1.027 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.585702e-02 | 1.018 |
| R-HSA-3371511 | HSF1 activation | 9.634977e-02 | 1.016 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.001148e-01 | 1.000 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.032843e-01 | 0.986 |
| R-HSA-162585 | Uncoating of the HIV Virion | 1.032843e-01 | 0.986 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.032843e-01 | 0.986 |
| R-HSA-8866423 | VLDL assembly | 1.032843e-01 | 0.986 |
| R-HSA-168256 | Immune System | 1.051851e-01 | 0.978 |
| R-HSA-9909396 | Circadian clock | 1.065665e-01 | 0.972 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.077651e-01 | 0.968 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.119569e-01 | 0.951 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.119569e-01 | 0.951 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.140839e-01 | 0.943 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.140839e-01 | 0.943 |
| R-HSA-8964041 | LDL remodeling | 1.140839e-01 | 0.943 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.140839e-01 | 0.943 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.155656e-01 | 0.937 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.155656e-01 | 0.937 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.195186e-01 | 0.923 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 1.196775e-01 | 0.922 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.223585e-01 | 0.912 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 1.235049e-01 | 0.908 |
| R-HSA-162589 | Reverse Transcription of HIV RNA | 1.247542e-01 | 0.904 |
| R-HSA-164516 | Minus-strand DNA synthesis | 1.247542e-01 | 0.904 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.247542e-01 | 0.904 |
| R-HSA-111995 | phospho-PLA2 pathway | 1.247542e-01 | 0.904 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.247542e-01 | 0.904 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.247542e-01 | 0.904 |
| R-HSA-9020933 | Interleukin-23 signaling | 1.247542e-01 | 0.904 |
| R-HSA-8854214 | TBC/RABGAPs | 1.275231e-01 | 0.894 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.315720e-01 | 0.881 |
| R-HSA-170984 | ARMS-mediated activation | 1.352966e-01 | 0.869 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 1.352966e-01 | 0.869 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.352966e-01 | 0.869 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.352966e-01 | 0.869 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.352966e-01 | 0.869 |
| R-HSA-448706 | Interleukin-1 processing | 1.352966e-01 | 0.869 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.352966e-01 | 0.869 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.352966e-01 | 0.869 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.352966e-01 | 0.869 |
| R-HSA-774815 | Nucleosome assembly | 1.356501e-01 | 0.868 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.356501e-01 | 0.868 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.394191e-01 | 0.856 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.397562e-01 | 0.855 |
| R-HSA-168249 | Innate Immune System | 1.423199e-01 | 0.847 |
| R-HSA-437239 | Recycling pathway of L1 | 1.438890e-01 | 0.842 |
| R-HSA-173107 | Binding and entry of HIV virion | 1.457126e-01 | 0.837 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.457126e-01 | 0.837 |
| R-HSA-5620924 | Intraflagellar transport | 1.480474e-01 | 0.830 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.480474e-01 | 0.830 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.491692e-01 | 0.826 |
| R-HSA-397014 | Muscle contraction | 1.524352e-01 | 0.817 |
| R-HSA-8963888 | Chylomicron assembly | 1.560039e-01 | 0.807 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.583811e-01 | 0.800 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.583811e-01 | 0.800 |
| R-HSA-912446 | Meiotic recombination | 1.606638e-01 | 0.794 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.620273e-01 | 0.790 |
| R-HSA-449147 | Signaling by Interleukins | 1.626602e-01 | 0.789 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 1.661717e-01 | 0.779 |
| R-HSA-428540 | Activation of RAC1 | 1.661717e-01 | 0.779 |
| R-HSA-162592 | Integration of provirus | 1.661717e-01 | 0.779 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.671175e-01 | 0.777 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.671175e-01 | 0.777 |
| R-HSA-1221632 | Meiotic synapsis | 1.691809e-01 | 0.772 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.691809e-01 | 0.772 |
| R-HSA-8951664 | Neddylation | 1.698776e-01 | 0.770 |
| R-HSA-418346 | Platelet homeostasis | 1.730192e-01 | 0.762 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.762177e-01 | 0.754 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.763026e-01 | 0.754 |
| R-HSA-162906 | HIV Infection | 1.819217e-01 | 0.740 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.820939e-01 | 0.740 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 1.861433e-01 | 0.730 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.861433e-01 | 0.730 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.861433e-01 | 0.730 |
| R-HSA-170968 | Frs2-mediated activation | 1.861433e-01 | 0.730 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.861433e-01 | 0.730 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.861433e-01 | 0.730 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.864308e-01 | 0.729 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.907821e-01 | 0.719 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 1.951471e-01 | 0.710 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.959499e-01 | 0.708 |
| R-HSA-1483115 | Hydrolysis of LPC | 1.959499e-01 | 0.708 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.959499e-01 | 0.708 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 1.959499e-01 | 0.708 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.995247e-01 | 0.700 |
| R-HSA-8873719 | RAB geranylgeranylation | 1.995247e-01 | 0.700 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 2.056389e-01 | 0.687 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 2.056389e-01 | 0.687 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.056389e-01 | 0.687 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.056389e-01 | 0.687 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.056389e-01 | 0.687 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.056389e-01 | 0.687 |
| R-HSA-196780 | Biotin transport and metabolism | 2.056389e-01 | 0.687 |
| R-HSA-186797 | Signaling by PDGF | 2.083141e-01 | 0.681 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 2.083141e-01 | 0.681 |
| R-HSA-373760 | L1CAM interactions | 2.095610e-01 | 0.679 |
| R-HSA-70326 | Glucose metabolism | 2.126824e-01 | 0.672 |
| R-HSA-373755 | Semaphorin interactions | 2.127241e-01 | 0.672 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.152118e-01 | 0.667 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 2.152118e-01 | 0.667 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.152118e-01 | 0.667 |
| R-HSA-2485179 | Activation of the phototransduction cascade | 2.152118e-01 | 0.667 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 2.152118e-01 | 0.667 |
| R-HSA-169893 | Prolonged ERK activation events | 2.152118e-01 | 0.667 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.152118e-01 | 0.667 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.215703e-01 | 0.654 |
| R-HSA-68875 | Mitotic Prophase | 2.221063e-01 | 0.653 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 2.246699e-01 | 0.648 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 2.246699e-01 | 0.648 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.246699e-01 | 0.648 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.246699e-01 | 0.648 |
| R-HSA-1566977 | Fibronectin matrix formation | 2.246699e-01 | 0.648 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.246699e-01 | 0.648 |
| R-HSA-6798695 | Neutrophil degranulation | 2.249900e-01 | 0.648 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.340146e-01 | 0.631 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.411926e-01 | 0.618 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.411926e-01 | 0.618 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.411926e-01 | 0.618 |
| R-HSA-112316 | Neuronal System | 2.430083e-01 | 0.614 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.432472e-01 | 0.614 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.432472e-01 | 0.614 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.432472e-01 | 0.614 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.438007e-01 | 0.613 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.523691e-01 | 0.598 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.523691e-01 | 0.598 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.571866e-01 | 0.590 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.613816e-01 | 0.583 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.613816e-01 | 0.583 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.613816e-01 | 0.583 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.613816e-01 | 0.583 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.613816e-01 | 0.583 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.613816e-01 | 0.583 |
| R-HSA-1181150 | Signaling by NODAL | 2.613816e-01 | 0.583 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 2.613816e-01 | 0.583 |
| R-HSA-9629569 | Protein hydroxylation | 2.613816e-01 | 0.583 |
| R-HSA-445144 | Signal transduction by L1 | 2.613816e-01 | 0.583 |
| R-HSA-5576891 | Cardiac conduction | 2.637848e-01 | 0.579 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.661185e-01 | 0.575 |
| R-HSA-202040 | G-protein activation | 2.702860e-01 | 0.568 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.702860e-01 | 0.568 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.702860e-01 | 0.568 |
| R-HSA-210991 | Basigin interactions | 2.702860e-01 | 0.568 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 2.702860e-01 | 0.568 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.750503e-01 | 0.561 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.790836e-01 | 0.554 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.790836e-01 | 0.554 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.795147e-01 | 0.554 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.877757e-01 | 0.541 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.877757e-01 | 0.541 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.877757e-01 | 0.541 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.877757e-01 | 0.541 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.914290e-01 | 0.535 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 2.963635e-01 | 0.528 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 2.963635e-01 | 0.528 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 2.963635e-01 | 0.528 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.963635e-01 | 0.528 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.973474e-01 | 0.527 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 3.048483e-01 | 0.516 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.048483e-01 | 0.516 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 3.048483e-01 | 0.516 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 3.048483e-01 | 0.516 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.048483e-01 | 0.516 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.048483e-01 | 0.516 |
| R-HSA-1500620 | Meiosis | 3.106800e-01 | 0.508 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.132313e-01 | 0.504 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.132313e-01 | 0.504 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.132313e-01 | 0.504 |
| R-HSA-9839394 | TGFBR3 expression | 3.132313e-01 | 0.504 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.132313e-01 | 0.504 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.151133e-01 | 0.502 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.215137e-01 | 0.493 |
| R-HSA-525793 | Myogenesis | 3.215137e-01 | 0.493 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.215137e-01 | 0.493 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 3.215137e-01 | 0.493 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 3.215137e-01 | 0.493 |
| R-HSA-70635 | Urea cycle | 3.215137e-01 | 0.493 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.215137e-01 | 0.493 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.283737e-01 | 0.484 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.296967e-01 | 0.482 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.296967e-01 | 0.482 |
| R-HSA-264876 | Insulin processing | 3.296967e-01 | 0.482 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.296967e-01 | 0.482 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.296967e-01 | 0.482 |
| R-HSA-1483257 | Phospholipid metabolism | 3.346121e-01 | 0.475 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 3.371762e-01 | 0.472 |
| R-HSA-9638334 | Iron assimilation using enterobactin | 3.377816e-01 | 0.471 |
| R-HSA-622312 | Inflammasomes | 3.377816e-01 | 0.471 |
| R-HSA-5334118 | DNA methylation | 3.457694e-01 | 0.461 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.457694e-01 | 0.461 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.457694e-01 | 0.461 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.458519e-01 | 0.461 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.503144e-01 | 0.456 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.536613e-01 | 0.451 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.536613e-01 | 0.451 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 3.536613e-01 | 0.451 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 3.552904e-01 | 0.449 |
| R-HSA-186763 | Downstream signal transduction | 3.614586e-01 | 0.442 |
| R-HSA-877300 | Interferon gamma signaling | 3.622822e-01 | 0.441 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.691622e-01 | 0.433 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.691622e-01 | 0.433 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.691622e-01 | 0.433 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 3.701696e-01 | 0.432 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.720093e-01 | 0.429 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.767734e-01 | 0.424 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.767734e-01 | 0.424 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.767734e-01 | 0.424 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.767734e-01 | 0.424 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.767734e-01 | 0.424 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.767734e-01 | 0.424 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.767734e-01 | 0.424 |
| R-HSA-9824439 | Bacterial Infection Pathways | 3.799454e-01 | 0.420 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 3.806077e-01 | 0.420 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.842932e-01 | 0.415 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.842932e-01 | 0.415 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.842932e-01 | 0.415 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.842932e-01 | 0.415 |
| R-HSA-3214847 | HATs acetylate histones | 3.848885e-01 | 0.415 |
| R-HSA-70171 | Glycolysis | 3.891566e-01 | 0.410 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.917227e-01 | 0.407 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.917227e-01 | 0.407 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.917227e-01 | 0.407 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.917227e-01 | 0.407 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.917227e-01 | 0.407 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.917227e-01 | 0.407 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.917227e-01 | 0.407 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.976533e-01 | 0.400 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.990631e-01 | 0.399 |
| R-HSA-187687 | Signalling to ERKs | 3.990631e-01 | 0.399 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.990631e-01 | 0.399 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.990631e-01 | 0.399 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 4.053039e-01 | 0.392 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 4.063153e-01 | 0.391 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.063153e-01 | 0.391 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.063153e-01 | 0.391 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.134804e-01 | 0.384 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.134804e-01 | 0.384 |
| R-HSA-110331 | Cleavage of the damaged purine | 4.134804e-01 | 0.384 |
| R-HSA-419037 | NCAM1 interactions | 4.134804e-01 | 0.384 |
| R-HSA-8948216 | Collagen chain trimerization | 4.134804e-01 | 0.384 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.175344e-01 | 0.379 |
| R-HSA-1474244 | Extracellular matrix organization | 4.204996e-01 | 0.376 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.205595e-01 | 0.376 |
| R-HSA-73927 | Depurination | 4.205595e-01 | 0.376 |
| R-HSA-9931953 | Biofilm formation | 4.205595e-01 | 0.376 |
| R-HSA-8875878 | MET promotes cell motility | 4.205595e-01 | 0.376 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.275536e-01 | 0.369 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.275536e-01 | 0.369 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.275536e-01 | 0.369 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.344637e-01 | 0.362 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.344637e-01 | 0.362 |
| R-HSA-3371568 | Attenuation phase | 4.344637e-01 | 0.362 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.344637e-01 | 0.362 |
| R-HSA-202433 | Generation of second messenger molecules | 4.344637e-01 | 0.362 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.412908e-01 | 0.355 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.412908e-01 | 0.355 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.412908e-01 | 0.355 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 4.441600e-01 | 0.352 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.480359e-01 | 0.349 |
| R-HSA-165159 | MTOR signalling | 4.547000e-01 | 0.342 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.547000e-01 | 0.342 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.547000e-01 | 0.342 |
| R-HSA-73928 | Depyrimidination | 4.547000e-01 | 0.342 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.547000e-01 | 0.342 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 4.554859e-01 | 0.342 |
| R-HSA-9710421 | Defective pyroptosis | 4.612840e-01 | 0.336 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.612840e-01 | 0.336 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.634904e-01 | 0.334 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.677890e-01 | 0.330 |
| R-HSA-375280 | Amine ligand-binding receptors | 4.677890e-01 | 0.330 |
| R-HSA-2980736 | Peptide hormone metabolism | 4.714260e-01 | 0.327 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.742158e-01 | 0.324 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.753674e-01 | 0.323 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 4.805654e-01 | 0.318 |
| R-HSA-9675135 | Diseases of DNA repair | 4.805654e-01 | 0.318 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.805654e-01 | 0.318 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.805654e-01 | 0.318 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.805654e-01 | 0.318 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.868387e-01 | 0.313 |
| R-HSA-73886 | Chromosome Maintenance | 4.870849e-01 | 0.312 |
| R-HSA-70263 | Gluconeogenesis | 4.930366e-01 | 0.307 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 4.930366e-01 | 0.307 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.948060e-01 | 0.306 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 4.991600e-01 | 0.302 |
| R-HSA-109704 | PI3K Cascade | 5.052098e-01 | 0.297 |
| R-HSA-9748787 | Azathioprine ADME | 5.052098e-01 | 0.297 |
| R-HSA-194138 | Signaling by VEGF | 5.062494e-01 | 0.296 |
| R-HSA-2514856 | The phototransduction cascade | 5.111870e-01 | 0.291 |
| R-HSA-72187 | mRNA 3'-end processing | 5.170923e-01 | 0.286 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.170923e-01 | 0.286 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.170923e-01 | 0.286 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.229266e-01 | 0.282 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.229266e-01 | 0.282 |
| R-HSA-8956320 | Nucleotide biosynthesis | 5.229266e-01 | 0.282 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.249458e-01 | 0.280 |
| R-HSA-1474165 | Reproduction | 5.286279e-01 | 0.277 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.286908e-01 | 0.277 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.343857e-01 | 0.272 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.400121e-01 | 0.268 |
| R-HSA-1483166 | Synthesis of PA | 5.455709e-01 | 0.263 |
| R-HSA-112399 | IRS-mediated signalling | 5.455709e-01 | 0.263 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.455709e-01 | 0.263 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.510628e-01 | 0.259 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.538592e-01 | 0.257 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.618494e-01 | 0.250 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.618494e-01 | 0.250 |
| R-HSA-379724 | tRNA Aminoacylation | 5.618494e-01 | 0.250 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.671456e-01 | 0.246 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.671456e-01 | 0.246 |
| R-HSA-1442490 | Collagen degradation | 5.671456e-01 | 0.246 |
| R-HSA-1268020 | Mitochondrial protein import | 5.723781e-01 | 0.242 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.723781e-01 | 0.242 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.723781e-01 | 0.242 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.826551e-01 | 0.235 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.826551e-01 | 0.235 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.877010e-01 | 0.231 |
| R-HSA-2187338 | Visual phototransduction | 5.948654e-01 | 0.226 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.948654e-01 | 0.226 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.982753e-01 | 0.223 |
| R-HSA-8957322 | Metabolism of steroids | 6.005667e-01 | 0.221 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 6.024776e-01 | 0.220 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 6.072851e-01 | 0.217 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.120348e-01 | 0.213 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 6.120348e-01 | 0.213 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.167272e-01 | 0.210 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.167272e-01 | 0.210 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.167272e-01 | 0.210 |
| R-HSA-3000178 | ECM proteoglycans | 6.167272e-01 | 0.210 |
| R-HSA-9638482 | Metal ion assimilation from the host | 6.167272e-01 | 0.210 |
| R-HSA-975634 | Retinoid metabolism and transport | 6.167272e-01 | 0.210 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.213633e-01 | 0.207 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.304686e-01 | 0.200 |
| R-HSA-5668914 | Diseases of metabolism | 6.338893e-01 | 0.198 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.393561e-01 | 0.194 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.480308e-01 | 0.188 |
| R-HSA-216083 | Integrin cell surface interactions | 6.480308e-01 | 0.188 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.564980e-01 | 0.183 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.564980e-01 | 0.183 |
| R-HSA-597592 | Post-translational protein modification | 6.577234e-01 | 0.182 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 6.606553e-01 | 0.180 |
| R-HSA-382551 | Transport of small molecules | 6.736936e-01 | 0.172 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.845685e-01 | 0.165 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 6.845685e-01 | 0.165 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.883877e-01 | 0.162 |
| R-HSA-73884 | Base Excision Repair | 6.995714e-01 | 0.155 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.032099e-01 | 0.153 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.035740e-01 | 0.153 |
| R-HSA-391251 | Protein folding | 7.103558e-01 | 0.149 |
| R-HSA-74752 | Signaling by Insulin receptor | 7.103558e-01 | 0.149 |
| R-HSA-392499 | Metabolism of proteins | 7.155827e-01 | 0.145 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.173306e-01 | 0.144 |
| R-HSA-157579 | Telomere Maintenance | 7.307827e-01 | 0.136 |
| R-HSA-9609690 | HCMV Early Events | 7.353745e-01 | 0.133 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.372679e-01 | 0.132 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.491205e-01 | 0.125 |
| R-HSA-9640148 | Infection with Enterobacteria | 7.513512e-01 | 0.124 |
| R-HSA-211000 | Gene Silencing by RNA | 7.645806e-01 | 0.117 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.674353e-01 | 0.115 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.730418e-01 | 0.112 |
| R-HSA-6803157 | Antimicrobial peptides | 7.757944e-01 | 0.110 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.785138e-01 | 0.109 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.785138e-01 | 0.109 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.812003e-01 | 0.107 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.072248e-01 | 0.093 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.110183e-01 | 0.091 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.110183e-01 | 0.091 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.243742e-01 | 0.084 |
| R-HSA-9717189 | Sensory perception of taste | 8.327521e-01 | 0.079 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 8.327521e-01 | 0.079 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.347836e-01 | 0.078 |
| R-HSA-9609646 | HCMV Infection | 8.400364e-01 | 0.076 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.459004e-01 | 0.073 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.537966e-01 | 0.069 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.585766e-01 | 0.066 |
| R-HSA-416476 | G alpha (q) signalling events | 8.599186e-01 | 0.066 |
| R-HSA-166520 | Signaling by NTRKs | 8.674264e-01 | 0.062 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.706315e-01 | 0.060 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.737595e-01 | 0.059 |
| R-HSA-2142753 | Arachidonate metabolism | 8.737595e-01 | 0.059 |
| R-HSA-1989781 | PPARA activates gene expression | 8.783109e-01 | 0.056 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.812541e-01 | 0.055 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 8.812541e-01 | 0.055 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.047510e-01 | 0.043 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.177830e-01 | 0.037 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.254693e-01 | 0.034 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.332647e-01 | 0.030 |
| R-HSA-72172 | mRNA Splicing | 9.348838e-01 | 0.029 |
| R-HSA-500792 | GPCR ligand binding | 9.397617e-01 | 0.027 |
| R-HSA-9748784 | Drug ADME | 9.451735e-01 | 0.024 |
| R-HSA-15869 | Metabolism of nucleotides | 9.560608e-01 | 0.020 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.565982e-01 | 0.019 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.621277e-01 | 0.017 |
| R-HSA-8978868 | Fatty acid metabolism | 9.669123e-01 | 0.015 |
| R-HSA-556833 | Metabolism of lipids | 9.955958e-01 | 0.002 |
| R-HSA-1430728 | Metabolism | 9.960070e-01 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 9.998845e-01 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 9.999841e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.872 | 0.215 | 2 | 0.880 |
CDC7 |
0.860 | 0.064 | 1 | 0.816 |
CLK3 |
0.860 | 0.194 | 1 | 0.748 |
PIM3 |
0.858 | 0.138 | -3 | 0.830 |
DSTYK |
0.857 | 0.102 | 2 | 0.883 |
NLK |
0.855 | 0.111 | 1 | 0.737 |
MOS |
0.854 | 0.069 | 1 | 0.797 |
ULK2 |
0.853 | 0.012 | 2 | 0.816 |
NDR2 |
0.852 | 0.038 | -3 | 0.841 |
PRPK |
0.852 | -0.064 | -1 | 0.855 |
GCN2 |
0.852 | -0.093 | 2 | 0.817 |
RAF1 |
0.851 | -0.032 | 1 | 0.756 |
WNK1 |
0.851 | 0.106 | -2 | 0.848 |
RSK2 |
0.850 | 0.101 | -3 | 0.763 |
TBK1 |
0.850 | -0.054 | 1 | 0.650 |
PKN3 |
0.850 | 0.067 | -3 | 0.839 |
SKMLCK |
0.850 | 0.105 | -2 | 0.813 |
CAMK1B |
0.849 | 0.032 | -3 | 0.862 |
NDR1 |
0.849 | 0.064 | -3 | 0.838 |
MST4 |
0.849 | 0.105 | 2 | 0.833 |
NUAK2 |
0.848 | 0.082 | -3 | 0.827 |
IKKB |
0.848 | -0.075 | -2 | 0.705 |
TGFBR2 |
0.848 | 0.007 | -2 | 0.730 |
PIM1 |
0.848 | 0.141 | -3 | 0.778 |
P90RSK |
0.848 | 0.073 | -3 | 0.770 |
NEK6 |
0.847 | 0.034 | -2 | 0.824 |
HUNK |
0.847 | 0.023 | 2 | 0.856 |
MTOR |
0.847 | -0.089 | 1 | 0.688 |
NEK7 |
0.847 | -0.026 | -3 | 0.864 |
RIPK3 |
0.847 | 0.040 | 3 | 0.743 |
BMPR2 |
0.846 | -0.063 | -2 | 0.831 |
AMPKA1 |
0.846 | 0.094 | -3 | 0.857 |
ERK5 |
0.846 | 0.031 | 1 | 0.689 |
MARK4 |
0.846 | 0.077 | 4 | 0.871 |
CDKL1 |
0.845 | 0.047 | -3 | 0.806 |
CAMK2G |
0.845 | -0.059 | 2 | 0.818 |
PKN2 |
0.845 | 0.077 | -3 | 0.843 |
PKCD |
0.845 | 0.121 | 2 | 0.799 |
IKKE |
0.845 | -0.098 | 1 | 0.643 |
PRKD1 |
0.844 | 0.041 | -3 | 0.840 |
RSK3 |
0.844 | 0.062 | -3 | 0.761 |
ULK1 |
0.844 | -0.054 | -3 | 0.853 |
NIK |
0.843 | 0.046 | -3 | 0.890 |
PRKD2 |
0.843 | 0.081 | -3 | 0.773 |
PDHK4 |
0.843 | -0.257 | 1 | 0.748 |
WNK3 |
0.843 | -0.048 | 1 | 0.710 |
BMPR1B |
0.842 | 0.165 | 1 | 0.821 |
MLK1 |
0.842 | 0.009 | 2 | 0.828 |
DAPK2 |
0.842 | 0.041 | -3 | 0.870 |
ATR |
0.842 | -0.039 | 1 | 0.739 |
CDKL5 |
0.842 | 0.044 | -3 | 0.800 |
PKACG |
0.842 | 0.051 | -2 | 0.714 |
CHAK2 |
0.842 | 0.059 | -1 | 0.893 |
P70S6KB |
0.841 | 0.060 | -3 | 0.795 |
LATS2 |
0.841 | 0.017 | -5 | 0.765 |
CAMLCK |
0.841 | 0.011 | -2 | 0.794 |
SRPK1 |
0.840 | 0.074 | -3 | 0.742 |
GRK1 |
0.840 | 0.058 | -2 | 0.717 |
NIM1 |
0.840 | 0.025 | 3 | 0.778 |
PDHK1 |
0.840 | -0.190 | 1 | 0.726 |
HIPK4 |
0.839 | 0.028 | 1 | 0.652 |
TSSK1 |
0.839 | 0.091 | -3 | 0.875 |
GRK6 |
0.839 | 0.028 | 1 | 0.794 |
TSSK2 |
0.839 | 0.067 | -5 | 0.793 |
AURC |
0.839 | 0.069 | -2 | 0.622 |
AMPKA2 |
0.839 | 0.069 | -3 | 0.823 |
MAPKAPK3 |
0.839 | 0.025 | -3 | 0.787 |
IKKA |
0.838 | -0.011 | -2 | 0.700 |
CAMK2D |
0.838 | -0.013 | -3 | 0.860 |
KIS |
0.838 | 0.013 | 1 | 0.602 |
PLK1 |
0.838 | 0.045 | -2 | 0.767 |
IRE1 |
0.838 | 0.043 | 1 | 0.667 |
NEK9 |
0.838 | -0.021 | 2 | 0.848 |
CDK8 |
0.838 | 0.006 | 1 | 0.618 |
CDK5 |
0.837 | 0.105 | 1 | 0.634 |
GRK5 |
0.837 | -0.117 | -3 | 0.858 |
MASTL |
0.836 | -0.142 | -2 | 0.771 |
ICK |
0.836 | 0.021 | -3 | 0.840 |
ANKRD3 |
0.836 | -0.001 | 1 | 0.772 |
MAPKAPK2 |
0.836 | 0.049 | -3 | 0.734 |
RSK4 |
0.836 | 0.093 | -3 | 0.729 |
PKCB |
0.835 | 0.102 | 2 | 0.750 |
TGFBR1 |
0.835 | 0.044 | -2 | 0.736 |
CLK1 |
0.835 | 0.101 | -3 | 0.729 |
MNK2 |
0.835 | 0.052 | -2 | 0.759 |
DRAK1 |
0.835 | 0.125 | 1 | 0.789 |
CDK19 |
0.834 | 0.013 | 1 | 0.588 |
CLK4 |
0.834 | 0.074 | -3 | 0.751 |
NUAK1 |
0.834 | 0.033 | -3 | 0.788 |
ALK4 |
0.834 | 0.019 | -2 | 0.758 |
SRPK2 |
0.834 | 0.063 | -3 | 0.669 |
PKCG |
0.834 | 0.078 | 2 | 0.760 |
IRE2 |
0.834 | 0.051 | 2 | 0.786 |
MELK |
0.834 | 0.039 | -3 | 0.811 |
BCKDK |
0.833 | -0.144 | -1 | 0.803 |
FAM20C |
0.833 | 0.056 | 2 | 0.607 |
CAMK2B |
0.833 | 0.042 | 2 | 0.773 |
DLK |
0.833 | -0.047 | 1 | 0.767 |
PKCA |
0.833 | 0.088 | 2 | 0.745 |
MLK3 |
0.833 | 0.064 | 2 | 0.756 |
AURB |
0.832 | 0.044 | -2 | 0.618 |
CDK1 |
0.832 | 0.073 | 1 | 0.580 |
CAMK4 |
0.832 | -0.051 | -3 | 0.823 |
RIPK1 |
0.831 | -0.102 | 1 | 0.708 |
QSK |
0.831 | 0.059 | 4 | 0.858 |
QIK |
0.831 | 0.003 | -3 | 0.836 |
ATM |
0.831 | -0.023 | 1 | 0.697 |
PKR |
0.831 | 0.081 | 1 | 0.725 |
PAK1 |
0.831 | -0.002 | -2 | 0.721 |
MARK3 |
0.831 | 0.093 | 4 | 0.840 |
MLK2 |
0.830 | -0.052 | 2 | 0.821 |
GRK4 |
0.830 | -0.105 | -2 | 0.759 |
PKG2 |
0.830 | 0.056 | -2 | 0.654 |
PKCZ |
0.830 | 0.067 | 2 | 0.797 |
CDK2 |
0.830 | 0.073 | 1 | 0.657 |
SGK3 |
0.830 | 0.073 | -3 | 0.761 |
LATS1 |
0.830 | 0.043 | -3 | 0.845 |
CDK7 |
0.830 | -0.006 | 1 | 0.614 |
MARK2 |
0.830 | 0.081 | 4 | 0.799 |
DYRK2 |
0.830 | 0.038 | 1 | 0.593 |
PKCH |
0.830 | 0.057 | 2 | 0.753 |
CLK2 |
0.829 | 0.129 | -3 | 0.733 |
ACVR2A |
0.829 | 0.037 | -2 | 0.720 |
PAK3 |
0.829 | -0.036 | -2 | 0.721 |
NEK2 |
0.829 | -0.004 | 2 | 0.827 |
CAMK2A |
0.829 | 0.022 | 2 | 0.789 |
CHAK1 |
0.829 | 0.029 | 2 | 0.792 |
MNK1 |
0.828 | 0.049 | -2 | 0.763 |
MSK2 |
0.828 | -0.026 | -3 | 0.745 |
PRKD3 |
0.828 | 0.028 | -3 | 0.733 |
P38A |
0.828 | 0.053 | 1 | 0.614 |
PHKG1 |
0.828 | 0.007 | -3 | 0.831 |
ACVR2B |
0.828 | 0.034 | -2 | 0.733 |
CDK18 |
0.827 | 0.039 | 1 | 0.551 |
MSK1 |
0.827 | 0.019 | -3 | 0.750 |
SRPK3 |
0.827 | 0.038 | -3 | 0.718 |
PIM2 |
0.827 | 0.101 | -3 | 0.739 |
CDK13 |
0.827 | 0.003 | 1 | 0.579 |
MLK4 |
0.827 | 0.035 | 2 | 0.737 |
MYLK4 |
0.827 | 0.012 | -2 | 0.721 |
JNK2 |
0.827 | 0.054 | 1 | 0.558 |
BMPR1A |
0.827 | 0.106 | 1 | 0.816 |
CDK3 |
0.826 | 0.106 | 1 | 0.526 |
TTBK2 |
0.826 | -0.148 | 2 | 0.748 |
SIK |
0.826 | 0.020 | -3 | 0.754 |
PLK4 |
0.826 | -0.010 | 2 | 0.709 |
ALK2 |
0.826 | 0.026 | -2 | 0.742 |
PKACB |
0.826 | 0.043 | -2 | 0.649 |
AURA |
0.826 | 0.006 | -2 | 0.582 |
VRK2 |
0.825 | -0.024 | 1 | 0.767 |
PAK2 |
0.825 | -0.028 | -2 | 0.702 |
MEK1 |
0.825 | -0.103 | 2 | 0.859 |
BRSK1 |
0.825 | -0.005 | -3 | 0.791 |
PAK6 |
0.824 | 0.020 | -2 | 0.646 |
BRSK2 |
0.824 | -0.022 | -3 | 0.825 |
JNK3 |
0.824 | 0.031 | 1 | 0.580 |
IRAK4 |
0.824 | 0.090 | 1 | 0.683 |
AKT2 |
0.824 | 0.056 | -3 | 0.671 |
P38G |
0.824 | 0.038 | 1 | 0.499 |
PLK3 |
0.824 | -0.037 | 2 | 0.800 |
YSK4 |
0.824 | -0.072 | 1 | 0.689 |
WNK4 |
0.823 | 0.040 | -2 | 0.835 |
MARK1 |
0.823 | 0.041 | 4 | 0.847 |
ERK2 |
0.823 | 0.024 | 1 | 0.570 |
PRP4 |
0.823 | 0.103 | -3 | 0.825 |
CAMK1G |
0.822 | 0.010 | -3 | 0.762 |
CDK9 |
0.822 | -0.006 | 1 | 0.587 |
CDK17 |
0.822 | 0.019 | 1 | 0.507 |
ERK1 |
0.822 | 0.024 | 1 | 0.543 |
GRK7 |
0.822 | 0.010 | 1 | 0.715 |
HIPK1 |
0.822 | 0.061 | 1 | 0.614 |
DCAMKL1 |
0.822 | 0.036 | -3 | 0.773 |
CDK14 |
0.822 | 0.055 | 1 | 0.593 |
DNAPK |
0.820 | -0.017 | 1 | 0.617 |
ZAK |
0.820 | 0.025 | 1 | 0.712 |
CHK1 |
0.820 | -0.030 | -3 | 0.842 |
MST3 |
0.820 | 0.116 | 2 | 0.841 |
CDK12 |
0.820 | -0.002 | 1 | 0.552 |
P38B |
0.820 | 0.028 | 1 | 0.544 |
SMG1 |
0.820 | -0.046 | 1 | 0.684 |
NEK5 |
0.819 | 0.063 | 1 | 0.732 |
PKCT |
0.819 | 0.057 | 2 | 0.755 |
CDK16 |
0.819 | 0.069 | 1 | 0.518 |
HIPK2 |
0.819 | 0.042 | 1 | 0.517 |
PRKX |
0.819 | 0.063 | -3 | 0.651 |
CDK10 |
0.819 | 0.082 | 1 | 0.583 |
SNRK |
0.819 | -0.117 | 2 | 0.749 |
MEKK1 |
0.818 | -0.028 | 1 | 0.725 |
GRK2 |
0.818 | -0.018 | -2 | 0.650 |
TLK2 |
0.818 | -0.093 | 1 | 0.688 |
DYRK1A |
0.818 | 0.017 | 1 | 0.636 |
MAPKAPK5 |
0.818 | -0.072 | -3 | 0.742 |
AKT1 |
0.817 | 0.065 | -3 | 0.692 |
GAK |
0.817 | 0.256 | 1 | 0.827 |
SMMLCK |
0.817 | 0.014 | -3 | 0.824 |
DYRK1B |
0.817 | 0.039 | 1 | 0.582 |
BRAF |
0.816 | -0.040 | -4 | 0.790 |
P38D |
0.816 | 0.055 | 1 | 0.519 |
PHKG2 |
0.816 | 0.007 | -3 | 0.790 |
P70S6K |
0.816 | 0.015 | -3 | 0.710 |
HRI |
0.816 | -0.112 | -2 | 0.788 |
SSTK |
0.815 | 0.036 | 4 | 0.837 |
DYRK4 |
0.815 | 0.037 | 1 | 0.544 |
DCAMKL2 |
0.815 | -0.005 | -3 | 0.797 |
PERK |
0.815 | -0.112 | -2 | 0.775 |
PKCI |
0.814 | 0.042 | 2 | 0.766 |
MEKK3 |
0.814 | -0.088 | 1 | 0.725 |
PKACA |
0.814 | 0.026 | -2 | 0.604 |
MEKK2 |
0.814 | -0.009 | 2 | 0.820 |
PASK |
0.813 | 0.045 | -3 | 0.845 |
MEK5 |
0.813 | -0.150 | 2 | 0.841 |
PKCE |
0.812 | 0.092 | 2 | 0.747 |
IRAK1 |
0.812 | -0.072 | -1 | 0.768 |
DYRK3 |
0.812 | 0.032 | 1 | 0.608 |
TAO3 |
0.812 | 0.016 | 1 | 0.709 |
HIPK3 |
0.812 | 0.006 | 1 | 0.598 |
MPSK1 |
0.812 | 0.090 | 1 | 0.715 |
DAPK3 |
0.811 | 0.045 | -3 | 0.788 |
PINK1 |
0.811 | -0.110 | 1 | 0.715 |
CAMK1D |
0.810 | 0.012 | -3 | 0.681 |
CAMKK1 |
0.810 | -0.004 | -2 | 0.751 |
CK2A2 |
0.809 | 0.072 | 1 | 0.732 |
NEK8 |
0.809 | -0.028 | 2 | 0.841 |
TLK1 |
0.809 | -0.139 | -2 | 0.770 |
LKB1 |
0.808 | 0.043 | -3 | 0.885 |
CDK6 |
0.808 | 0.054 | 1 | 0.576 |
CK1E |
0.808 | -0.046 | -3 | 0.512 |
NEK11 |
0.808 | -0.052 | 1 | 0.711 |
CAMKK2 |
0.807 | 0.011 | -2 | 0.746 |
TAO2 |
0.806 | -0.009 | 2 | 0.856 |
DAPK1 |
0.806 | 0.034 | -3 | 0.771 |
JNK1 |
0.805 | 0.030 | 1 | 0.554 |
PAK5 |
0.805 | -0.034 | -2 | 0.575 |
GCK |
0.805 | 0.045 | 1 | 0.729 |
NEK4 |
0.805 | -0.006 | 1 | 0.681 |
AKT3 |
0.804 | 0.055 | -3 | 0.610 |
PKN1 |
0.804 | 0.012 | -3 | 0.722 |
EEF2K |
0.804 | 0.056 | 3 | 0.851 |
PAK4 |
0.804 | -0.025 | -2 | 0.583 |
MEKK6 |
0.803 | 0.014 | 1 | 0.701 |
GRK3 |
0.803 | -0.034 | -2 | 0.602 |
MRCKA |
0.803 | 0.064 | -3 | 0.752 |
CDK4 |
0.803 | 0.025 | 1 | 0.538 |
MINK |
0.803 | 0.033 | 1 | 0.696 |
TTBK1 |
0.802 | -0.148 | 2 | 0.673 |
PBK |
0.802 | 0.184 | 1 | 0.772 |
SGK1 |
0.802 | 0.047 | -3 | 0.596 |
MAP3K15 |
0.802 | 0.005 | 1 | 0.685 |
MST2 |
0.802 | -0.029 | 1 | 0.730 |
TNIK |
0.802 | 0.077 | 3 | 0.872 |
ROCK2 |
0.801 | 0.083 | -3 | 0.784 |
MRCKB |
0.801 | 0.053 | -3 | 0.733 |
NEK1 |
0.801 | 0.045 | 1 | 0.694 |
HGK |
0.801 | 0.031 | 3 | 0.866 |
ERK7 |
0.801 | 0.019 | 2 | 0.549 |
CK2A1 |
0.801 | 0.063 | 1 | 0.718 |
PDK1 |
0.801 | -0.070 | 1 | 0.701 |
GSK3B |
0.800 | -0.044 | 4 | 0.427 |
GSK3A |
0.799 | -0.014 | 4 | 0.436 |
VRK1 |
0.798 | -0.011 | 2 | 0.875 |
CHK2 |
0.798 | 0.007 | -3 | 0.618 |
STK33 |
0.798 | -0.078 | 2 | 0.664 |
LOK |
0.797 | -0.003 | -2 | 0.733 |
MAK |
0.797 | 0.065 | -2 | 0.685 |
HPK1 |
0.797 | -0.005 | 1 | 0.699 |
CK1D |
0.797 | -0.055 | -3 | 0.461 |
CAMK1A |
0.797 | 0.005 | -3 | 0.642 |
CK1A2 |
0.796 | -0.044 | -3 | 0.458 |
LRRK2 |
0.796 | -0.071 | 2 | 0.868 |
MST1 |
0.796 | -0.018 | 1 | 0.698 |
PLK2 |
0.796 | -0.019 | -3 | 0.804 |
CK1G1 |
0.796 | -0.089 | -3 | 0.493 |
DMPK1 |
0.795 | 0.095 | -3 | 0.743 |
BUB1 |
0.795 | 0.079 | -5 | 0.769 |
KHS2 |
0.795 | 0.063 | 1 | 0.693 |
TAK1 |
0.794 | -0.087 | 1 | 0.738 |
MOK |
0.794 | 0.060 | 1 | 0.599 |
KHS1 |
0.794 | 0.027 | 1 | 0.669 |
YSK1 |
0.793 | 0.012 | 2 | 0.812 |
RIPK2 |
0.793 | -0.167 | 1 | 0.665 |
BIKE |
0.791 | 0.218 | 1 | 0.755 |
NEK3 |
0.790 | -0.041 | 1 | 0.662 |
MEK2 |
0.790 | -0.176 | 2 | 0.835 |
ROCK1 |
0.789 | 0.053 | -3 | 0.753 |
TTK |
0.789 | 0.048 | -2 | 0.773 |
PKG1 |
0.788 | -0.012 | -2 | 0.571 |
OSR1 |
0.788 | 0.046 | 2 | 0.802 |
SLK |
0.788 | -0.072 | -2 | 0.669 |
PDHK3_TYR |
0.785 | 0.145 | 4 | 0.869 |
SBK |
0.785 | -0.010 | -3 | 0.553 |
CRIK |
0.782 | 0.038 | -3 | 0.695 |
MYO3B |
0.780 | 0.027 | 2 | 0.826 |
TESK1_TYR |
0.779 | 0.018 | 3 | 0.878 |
ASK1 |
0.779 | -0.053 | 1 | 0.672 |
HASPIN |
0.777 | -0.013 | -1 | 0.717 |
TAO1 |
0.777 | -0.036 | 1 | 0.626 |
PKMYT1_TYR |
0.776 | 0.021 | 3 | 0.855 |
AAK1 |
0.776 | 0.240 | 1 | 0.676 |
MAP2K6_TYR |
0.775 | 0.007 | -1 | 0.883 |
MYO3A |
0.775 | -0.010 | 1 | 0.657 |
EPHA6 |
0.775 | 0.099 | -1 | 0.859 |
MAP2K4_TYR |
0.775 | -0.058 | -1 | 0.876 |
LIMK2_TYR |
0.774 | 0.055 | -3 | 0.919 |
BMPR2_TYR |
0.774 | 0.033 | -1 | 0.868 |
EPHB4 |
0.774 | 0.101 | -1 | 0.835 |
PDHK4_TYR |
0.774 | 0.001 | 2 | 0.874 |
MAP2K7_TYR |
0.773 | -0.133 | 2 | 0.875 |
TXK |
0.773 | 0.157 | 1 | 0.845 |
PINK1_TYR |
0.772 | -0.071 | 1 | 0.733 |
TYRO3 |
0.771 | 0.038 | 3 | 0.824 |
PDHK1_TYR |
0.771 | -0.063 | -1 | 0.889 |
ITK |
0.769 | 0.130 | -1 | 0.779 |
LIMK1_TYR |
0.769 | -0.049 | 2 | 0.868 |
YES1 |
0.768 | 0.066 | -1 | 0.813 |
ROS1 |
0.768 | 0.006 | 3 | 0.798 |
ALPHAK3 |
0.767 | -0.090 | -1 | 0.785 |
YANK3 |
0.767 | -0.078 | 2 | 0.432 |
RET |
0.766 | -0.057 | 1 | 0.688 |
MST1R |
0.766 | -0.065 | 3 | 0.837 |
DDR1 |
0.765 | -0.061 | 4 | 0.806 |
LCK |
0.765 | 0.125 | -1 | 0.798 |
STLK3 |
0.765 | -0.127 | 1 | 0.666 |
EPHB3 |
0.765 | 0.055 | -1 | 0.815 |
TYK2 |
0.764 | -0.094 | 1 | 0.686 |
EPHB1 |
0.764 | 0.043 | 1 | 0.796 |
EPHB2 |
0.764 | 0.066 | -1 | 0.812 |
HCK |
0.764 | 0.054 | -1 | 0.799 |
FER |
0.764 | -0.025 | 1 | 0.813 |
FGR |
0.764 | 0.020 | 1 | 0.798 |
INSRR |
0.764 | -0.010 | 3 | 0.766 |
BLK |
0.763 | 0.122 | -1 | 0.806 |
CK1A |
0.763 | -0.067 | -3 | 0.363 |
CSF1R |
0.763 | -0.039 | 3 | 0.809 |
JAK3 |
0.762 | -0.010 | 1 | 0.692 |
TNK2 |
0.762 | 0.019 | 3 | 0.779 |
EPHA4 |
0.762 | 0.008 | 2 | 0.796 |
ABL2 |
0.761 | 0.001 | -1 | 0.792 |
PDGFRB |
0.761 | -0.019 | 3 | 0.824 |
JAK2 |
0.761 | -0.105 | 1 | 0.689 |
SRMS |
0.760 | -0.007 | 1 | 0.805 |
MERTK |
0.759 | 0.021 | 3 | 0.785 |
TNNI3K_TYR |
0.759 | 0.059 | 1 | 0.700 |
BMX |
0.759 | 0.036 | -1 | 0.697 |
AXL |
0.757 | -0.025 | 3 | 0.786 |
TEC |
0.757 | 0.016 | -1 | 0.713 |
TNK1 |
0.757 | -0.013 | 3 | 0.800 |
TEK |
0.756 | -0.044 | 3 | 0.768 |
ABL1 |
0.756 | -0.029 | -1 | 0.783 |
KDR |
0.756 | -0.018 | 3 | 0.761 |
FGFR2 |
0.754 | -0.100 | 3 | 0.790 |
PTK2B |
0.754 | 0.050 | -1 | 0.750 |
FLT3 |
0.754 | -0.078 | 3 | 0.820 |
FYN |
0.754 | 0.070 | -1 | 0.765 |
KIT |
0.754 | -0.082 | 3 | 0.813 |
EPHA7 |
0.754 | 0.003 | 2 | 0.803 |
BTK |
0.753 | -0.055 | -1 | 0.743 |
DDR2 |
0.753 | 0.042 | 3 | 0.744 |
EPHA1 |
0.752 | -0.013 | 3 | 0.795 |
FGFR1 |
0.752 | -0.099 | 3 | 0.780 |
ALK |
0.751 | -0.059 | 3 | 0.751 |
MET |
0.751 | -0.059 | 3 | 0.806 |
JAK1 |
0.751 | -0.064 | 1 | 0.649 |
EPHA3 |
0.750 | -0.051 | 2 | 0.776 |
INSR |
0.750 | -0.065 | 3 | 0.755 |
WEE1_TYR |
0.750 | -0.045 | -1 | 0.743 |
LTK |
0.749 | -0.069 | 3 | 0.764 |
NEK10_TYR |
0.749 | -0.133 | 1 | 0.562 |
PDGFRA |
0.749 | -0.144 | 3 | 0.826 |
FRK |
0.748 | -0.039 | -1 | 0.815 |
EPHA5 |
0.748 | 0.005 | 2 | 0.786 |
NTRK1 |
0.748 | -0.130 | -1 | 0.806 |
LYN |
0.748 | -0.005 | 3 | 0.739 |
NTRK2 |
0.747 | -0.101 | 3 | 0.774 |
FLT1 |
0.745 | -0.071 | -1 | 0.834 |
ERBB2 |
0.745 | -0.130 | 1 | 0.690 |
PTK6 |
0.744 | -0.154 | -1 | 0.703 |
SRC |
0.744 | -0.002 | -1 | 0.761 |
FGFR3 |
0.744 | -0.110 | 3 | 0.767 |
PTK2 |
0.744 | 0.061 | -1 | 0.793 |
EPHA8 |
0.744 | -0.031 | -1 | 0.786 |
FLT4 |
0.743 | -0.118 | 3 | 0.753 |
NTRK3 |
0.741 | -0.111 | -1 | 0.754 |
MATK |
0.737 | -0.109 | -1 | 0.726 |
YANK2 |
0.736 | -0.094 | 2 | 0.444 |
SYK |
0.735 | -0.005 | -1 | 0.770 |
EPHA2 |
0.735 | -0.033 | -1 | 0.766 |
EGFR |
0.735 | -0.096 | 1 | 0.617 |
CK1G3 |
0.734 | -0.094 | -3 | 0.311 |
IGF1R |
0.734 | -0.092 | 3 | 0.697 |
MUSK |
0.732 | -0.107 | 1 | 0.587 |
CSK |
0.731 | -0.156 | 2 | 0.807 |
FGFR4 |
0.730 | -0.118 | -1 | 0.762 |
ERBB4 |
0.725 | -0.078 | 1 | 0.654 |
FES |
0.722 | -0.084 | -1 | 0.672 |
CK1G2 |
0.718 | -0.080 | -3 | 0.410 |
ZAP70 |
0.708 | -0.075 | -1 | 0.693 |