Motif 718 (n=230)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L170 | C1orf226 | S222 | ochoa | Uncharacterized protein C1orf226 | None |
| A6NKT7 | RGPD3 | S1482 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O00160 | MYO1F | S734 | ochoa | Unconventional myosin-If (Myosin-Ie) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}. |
| O00401 | WASL | S426 | ochoa | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742). {ECO:0000250|UniProtKB:Q91YD9, ECO:0000269|PubMed:16767080, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828, ECO:0000269|PubMed:9422512}. |
| O00482 | NR5A2 | S510 | psp | Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1) | Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as early embryonic development, cholesterol and bile acid synthesis pathways, as well as liver and pancreas morphogenesis (PubMed:16289203, PubMed:18410128, PubMed:21614002, PubMed:32433991, PubMed:38409506, PubMed:9786908). Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation (PubMed:21614002). The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine can act as ligand in vitro (PubMed:15707893, PubMed:15723037, PubMed:15897460, PubMed:21614002, PubMed:22504882, PubMed:23737522, PubMed:26416531, PubMed:26553876). Acts as a pioneer transcription factor, which unwraps target DNA from histones and elicits local opening of closed chromatin (PubMed:38409506). Plays a central role during preimplantation stages of embryonic development (By similarity). Plays a minor role in zygotic genome activation (ZGA) by regulating a small set of two-cell stage genes (By similarity). Plays a major role in morula development (2-16 cells embryos) by acting as a master regulator at the 8-cell stage, controlling expression of lineage-specifying transcription factors and genes involved in mitosis, telomere maintenance and DNA repair (By similarity). Zygotic NR5A2 binds to both closed and open chromatin with other transcription factors, often at SINE B1/Alu repeats DNA elements, promoting chromatin accessibility at nearby regulatory regions (By similarity). Also involved in the epiblast stage of development and embryonic stem cell pluripotency, by promoting expression of POU5F1/OCT4 (PubMed:27984042). Regulates other processes later in development, such as formation of connective tissue in lower jaw and middle ear, neural stem cell differentiation, ovarian follicle development and Sertoli cell differentiation (By similarity). Involved in exocrine pancreas development and acinar cell differentiation (By similarity). Acts as an essential transcriptional regulator of lipid metabolism (PubMed:20159957). Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver (PubMed:10359768). Also acts as a negative regulator of inflammation in different organs, such as, liver and pancreas (PubMed:20159957). Protects against intestinal inflammation via its ability to regulate glucocorticoid production (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Acts as a regulator of immunity by promoting lymphocyte T-cell development, proliferation and effector functions (By similarity). Also involved in resolution of endoplasmic reticulum stress in the liver (By similarity). {ECO:0000250|UniProtKB:P45448, ECO:0000269|PubMed:10359768, ECO:0000269|PubMed:15707893, ECO:0000269|PubMed:15723037, ECO:0000269|PubMed:15897460, ECO:0000269|PubMed:16289203, ECO:0000269|PubMed:18410128, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:21614002, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23737522, ECO:0000269|PubMed:26416531, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:27984042, ECO:0000269|PubMed:32433991, ECO:0000269|PubMed:38409506, ECO:0000269|PubMed:9786908}.; FUNCTION: [Isoform 3]: In constrast to isoform 1 and isoform 2, does not induce cholesterol 7-alpha-hydroxylase gene (CYP7A) promoter activity. {ECO:0000269|PubMed:10359768}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with HNF1A to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269|PubMed:14728801, ECO:0000269|PubMed:9786908}. |
| O14715 | RGPD8 | S1481 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15027 | SEC16A | S1801 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15119 | TBX3 | S719 | psp | T-box transcription factor TBX3 (T-box protein 3) | Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}. |
| O15360 | FANCA | S165 | psp | Fanconi anemia group A protein (Protein FACA) | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. |
| O43379 | WDR62 | S1048 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43752 | STX6 | S152 | ochoa | Syntaxin-6 | SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. {ECO:0000250|UniProtKB:Q63635}. |
| O60499 | STX10 | S146 | ochoa | Syntaxin-10 (Syn10) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O60563 | CCNT1 | S352 | ochoa | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O60583 | CCNT2 | S424 | ochoa | Cyclin-T2 (CycT2) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:15563843, PubMed:9499409). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). {ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533, ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689, ECO:0000269|PubMed:9499409}.; FUNCTION: (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. {ECO:0000269|PubMed:21509660}. |
| O60664 | PLIN3 | S91 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60673 | REV3L | S2410 | ochoa | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}. |
| O60701 | UGDH | S275 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O60759 | CYTIP | S222 | ochoa | Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) | By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm. |
| O75150 | RNF40 | S819 | psp | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75396 | SEC22B | S175 | ochoa | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| O75691 | UTP20 | S788 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
| O75792 | RNASEH2A | S208 | psp | Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) | Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}. |
| O76003 | GLRX3 | S117 | ochoa | Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) | Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250|UniProtKB:Q9CQM9, ECO:0000269|PubMed:23615448, ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}. |
| O94864 | SUPT7L | S327 | ochoa | STAGA complex 65 subunit gamma (Adenocarcinoma antigen ART1) (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like) | None |
| O95613 | PCNT | S2044 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95613 | PCNT | S3014 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95684 | CEP43 | S305 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| O95777 | LSM8 | S47 | ochoa | U6 snRNA-associated Sm-like protein LSm8 | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}. |
| P00736 | C1R | S206 | psp | Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain (Complement C1r subcomponent chain A); Complement C1r subcomponent light chain (Complement C1r subcomponent chain B)] | Serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:17996945, PubMed:19473974, PubMed:29449492). C1R catalyzes the first enzymatic step in the classical complement pathway: it is activated by the C1Q subcomplex of the C1 complex, which associates with IgG or IgM immunoglobulins complexed with antigens to form antigen-antibody complexes on the surface of pathogens (PubMed:29449492, PubMed:34155115). Immunoglobulin-binding promotes the autocatalytic cleavage and activation of C1R (PubMed:11445589, PubMed:11673533, PubMed:17996945, PubMed:20178990, PubMed:6254570, PubMed:6271784). Activated C1R then cleaves and activates C1S, the second protease of the classical complement pathway (PubMed:11445589, PubMed:11673533, PubMed:6271784). It is unclear if C1R activates C1S within single, strained C1 complexes or between neighboring C1 complexes on surfaces (PubMed:28104818, PubMed:29311313, PubMed:29449492). {ECO:0000269|PubMed:11445589, ECO:0000269|PubMed:11673533, ECO:0000269|PubMed:17996945, ECO:0000269|PubMed:19473974, ECO:0000269|PubMed:20178990, ECO:0000269|PubMed:28104818, ECO:0000269|PubMed:29311313, ECO:0000269|PubMed:29449492, ECO:0000269|PubMed:34155115, ECO:0000269|PubMed:6254570, ECO:0000269|PubMed:6271784}. |
| P00918 | CA2 | S172 | ochoa | Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) | Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}. |
| P01033 | TIMP1 | S178 | ochoa | Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1) | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. {ECO:0000269|PubMed:1420137, ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:17050530, ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:20545310, ECO:0000269|PubMed:22427646, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540, ECO:0000269|PubMed:8576151, ECO:0000269|PubMed:9065415}. |
| P03952 | KLKB1 | S67 | ochoa | Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] | Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. |
| P04843 | RPN1 | S535 | ochoa | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). {ECO:0000250|UniProtKB:E2RQ08, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:39567208}. |
| P05141 | SLC25A5 | S22 | ochoa | ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed] | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P51881, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:31883789}. |
| P07900 | HSP90AA1 | S391 | psp | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08240 | SRPRA | S46 | ochoa | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}. |
| P0DJD0 | RGPD1 | S1466 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1474 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P12236 | SLC25A6 | S22 | ochoa | ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed] | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:15033708). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:15033708}. |
| P12883 | MYH7 | S1261 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P15735 | PHKG2 | S345 | ochoa | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (PubMed:35549678). {ECO:0000250|UniProtKB:P31325, ECO:0000269|PubMed:10487978, ECO:0000269|PubMed:35549678}. |
| P18206 | VCL | S383 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P20929 | NEB | S3948 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P21333 | FLNA | S189 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21452 | TACR2 | S345 | ochoa | Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) | This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. {ECO:0000269|PubMed:1659297}. |
| P22090 | RPS4Y1 | S32 | ochoa | Small ribosomal subunit protein eS4, Y isoform 1 (40S ribosomal protein S4) | None |
| P22681 | CBL | S866 | psp | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P23526 | AHCY | S187 | ochoa | Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) | Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity). {ECO:0000250|UniProtKB:P50247, ECO:0000269|PubMed:10933798}. |
| P24941 | CDK2 | S46 | psp | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:17495531, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226, PubMed:28666995). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2 (PubMed:10499802, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226). Triggers duplication of centrosomes and DNA (PubMed:11051553). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (PubMed:18372919, PubMed:19238148, PubMed:19561645). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (PubMed:18372919, PubMed:19238148, PubMed:19561645). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (PubMed:18372919, PubMed:19238148, PubMed:19561645). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (PubMed:19966300). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (PubMed:15800615, PubMed:20195506, PubMed:21319273). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (PubMed:15800615). Involved in regulation of telomere repair by mediating phosphorylation of NBN (PubMed:28216226). Phosphorylation of RB1 disturbs its interaction with E2F1 (PubMed:10499802). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication (PubMed:11051553). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (PubMed:10995386, PubMed:10995387). Required for vitamin D-mediated growth inhibition by being itself inactivated (PubMed:20147522). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (PubMed:20079829). USP37 is activated by phosphorylation and thus triggers G1-S transition (PubMed:21596315). CTNNB1 phosphorylation regulates insulin internalization (PubMed:21262353). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (PubMed:24670654). {ECO:0000250|UniProtKB:P97377, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:11051553, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:12944431, ECO:0000269|PubMed:15800615, ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:18372919, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20079829, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20195506, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:21319273, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:29203878, ECO:0000303|PubMed:19238148, ECO:0000303|PubMed:19561645}. |
| P29274 | ADORA2A | S374 | psp | Adenosine receptor A2a | Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:P11617}. |
| P29353 | SHC1 | S513 | ochoa | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P30304 | CDC25A | S107 | psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30304 | CDC25A | S261 | ochoa | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P31629 | HIVEP2 | S951 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P35573 | AGL | S1028 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P35579 | MYH9 | S1628 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S1266 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35749 | MYH11 | S1635 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P37275 | ZEB1 | S521 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P38432 | COIL | S94 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P42704 | LRPPRC | S742 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P48048 | KCNJ1 | S219 | psp | ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. {ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:7929082}. |
| P48643 | CCT5 | S26 | ochoa | T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P49792 | RANBP2 | S2457 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50991 | CCT4 | S236 | ochoa | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51530 | DNA2 | S202 | ochoa | DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)] | Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function. {ECO:0000269|PubMed:16595799, ECO:0000269|PubMed:16595800, ECO:0000269|PubMed:18995831, ECO:0000269|PubMed:19487465, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:21572043, ECO:0000269|PubMed:22570407, ECO:0000269|PubMed:22570476, ECO:0000269|PubMed:31478350}. |
| P53675 | CLTCL1 | S1016 | ochoa | Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}. |
| P54646 | PRKAA2 | S504 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| P54886 | ALDH18A1 | S136 | ochoa | Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] | Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. {ECO:0000269|PubMed:10037775, ECO:0000269|PubMed:11092761, ECO:0000269|PubMed:26297558, ECO:0000269|PubMed:26320891, ECO:0000269|PubMed:39506109}. |
| P55209 | NAP1L1 | S69 | ochoa | Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP) | Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:21211722, PubMed:26841755). Also participates in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair (PubMed:28369616). Also stimulates homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (PubMed:24798879). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). {ECO:0000250|UniProtKB:P28656, ECO:0000269|PubMed:20002496, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:24798879, ECO:0000269|PubMed:26841755, ECO:0000269|PubMed:28369616}.; FUNCTION: (Microbial infection) Positively regulates Epstein-Barr virus reactivation in epithelial cells through the induction of viral BZLF1 expression. {ECO:0000269|PubMed:23691099}.; FUNCTION: (Microbial infection) Together with human herpesvirus 8 protein LANA1, assists the proper assembly of the nucleosome on the replicated viral DNA. {ECO:0000269|PubMed:27599637}. |
| P57078 | RIPK4 | S446 | ochoa | Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) | Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}. |
| P61081 | UBE2M | S50 | ochoa | NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M) | Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:15361859}. |
| P62701 | RPS4X | S32 | ochoa | Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P78527 | PRKDC | S2117 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P78527 | PRKDC | S2655 | ochoa|psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P85037 | FOXK1 | S213 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q00341 | HDLBP | S363 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q00610 | CLTC | S1016 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q01082 | SPTBN1 | S903 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01094 | E2F1 | S403 | psp | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:18625225, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:8170954}. |
| Q01826 | SATB1 | S185 | psp | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. |
| Q01831 | XPC | S94 | ochoa|psp | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q04656 | ATP7A | S1476 | psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q07666 | KHDRBS1 | S113 | ochoa | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q08AD1 | CAMSAP2 | S598 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q0P6D2 | DIPK1C | S51 | psp | Divergent protein kinase domain 1C (Protein FAM69C) | None |
| Q12834 | CDC20 | S104 | ochoa | Cell division cycle protein 20 homolog (p55CDC) | Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
| Q12948 | FOXC1 | S527 | ochoa | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}. |
| Q13007 | IL24 | S101 | psp | Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein) | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity). {ECO:0000250|UniProtKB:Q925S4, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:25168428, ECO:0000269|PubMed:27687232, ECO:0000269|PubMed:30111632}. |
| Q13021 | MALL | S63 | ochoa | MAL-like protein (Protein BENE) | None |
| Q13144 | EIF2B5 | S610 | ochoa | Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
| Q13151 | HNRNPA0 | S88 | ochoa | Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) | mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}. |
| Q13415 | ORC1 | S610 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13813 | SPTAN1 | S2138 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13835 | PKP1 | S233 | ochoa | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q14005 | IL16 | S863 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Q14315 | FLNC | S1962 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14863 | POU6F1 | S197 | psp | POU domain, class 6, transcription factor 1 (Brain-specific homeobox/POU domain protein 5) (Brain-5) (Brn-5) (mPOU homeobox protein) | Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3'). {ECO:0000250}. |
| Q15032 | R3HDM1 | S141 | ochoa | R3H domain-containing protein 1 | None |
| Q15365 | PCBP1 | S223 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15643 | TRIP11 | S755 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q4KMP7 | TBC1D10B | S289 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q53QZ3 | ARHGAP15 | S243 | ochoa | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
| Q5T0W9 | FAM83B | S538 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T5X7 | BEND3 | S39 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5T6S3 | PHF19 | S366 | ochoa | PHD finger protein 19 (Polycomb-like protein 3) (hPCL3) | Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23104054, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:31959557). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832). {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:23273982, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q5THJ4 | VPS13D | S1067 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5UIP0 | RIF1 | S2401 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q68DA7 | FMN1 | S199 | ochoa | Formin-1 (Limb deformity protein homolog) | Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}. |
| Q68DA7 | FMN1 | S842 | ochoa | Formin-1 (Limb deformity protein homolog) | Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}. |
| Q6P0N0 | MIS18BP1 | S729 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P2H3 | CEP85 | S623 | ochoa | Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) | Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292}. |
| Q6UXG2 | ELAPOR1 | S990 | ochoa | Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein) | May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway (PubMed:21072319). May play a role in apoptosis and cell proliferation through its interaction with HSPA5 (PubMed:26045166). {ECO:0000269|PubMed:21072319, ECO:0000269|PubMed:26045166}. |
| Q6W2J9 | BCOR | S177 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6XQN6 | NAPRT | S513 | ochoa | Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) (FHA-HIT-interacting protein) (Nicotinate phosphoribosyltransferase domain-containing protein 1) | Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275). {ECO:0000269|PubMed:17604275, ECO:0000269|PubMed:21742010, ECO:0000269|PubMed:26042198}. |
| Q7L591 | DOK3 | S389 | ochoa | Docking protein 3 (Downstream of tyrosine kinase 3) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}. |
| Q7Z2W4 | ZC3HAV1 | S101 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z2W4 | ZC3HAV1 | S114 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z2W4 | ZC3HAV1 | S327 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z2W4 | ZC3HAV1 | S502 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3J3 | RGPD4 | S1482 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3T8 | ZFYVE16 | S557 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z418 | KCNK18 | S267 | psp | Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) | K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation of Ca(2+)-mobilizing receptors (PubMed:12754259, PubMed:15562060, PubMed:20871611, PubMed:22355750, PubMed:26919430, PubMed:30573346). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimers of KCNK18/TRESK and KCNK2/TREK-1 or KCNK10/TREK-2 inhibit neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). In thymocytes, conducts K(+) currents upon T cell receptor (TCR) signaling leading to sustained Ca(2+) influx and NF-kappa-B activation, FOXP3 transcription and positive selection of regulatory T cell (Treg) progenitor subsets (PubMed:34702947). Appears to mediate the analgesics effects of hydroxy-alpha-sanshool, a metabolite naturally present in Schezuan pepper and other Xanthoxylum plants (By similarity). {ECO:0000250|UniProtKB:Q6VV64, ECO:0000269|PubMed:12754259, ECO:0000269|PubMed:15562060, ECO:0000269|PubMed:20871611, ECO:0000269|PubMed:22355750, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:30573346, ECO:0000269|PubMed:34702947}. |
| Q7Z6Z7 | HUWE1 | S2527 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z7A1 | CNTRL | S831 | ochoa | Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) | Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. {ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:16213214}. |
| Q86V48 | LUZP1 | S1042 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86VP1 | TAX1BP1 | S344 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86YV0 | RASAL3 | S949 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8HWS3 | RFX6 | S21 | ochoa | DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1) | Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100). {ECO:0000269|PubMed:20148032, ECO:0000269|PubMed:25497100}. |
| Q8IUD2 | ERC1 | S687 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IUR7 | ARMC8 | S339 | ochoa | Armadillo repeat-containing protein 8 | Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. {ECO:0000269|PubMed:29911972}. |
| Q8IX01 | SUGP2 | S825 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IY18 | SMC5 | S793 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Q8IY57 | YAF2 | S111 | ochoa | YY1-associated factor 2 | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
| Q8IYB8 | SUPV3L1 | S725 | ochoa | ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1) | Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:15096047, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:17961633, ECO:0000269|PubMed:18678873, ECO:0000269|PubMed:19509288, ECO:0000269|PubMed:19864255, ECO:0000269|PubMed:29967381}. |
| Q8N1F7 | NUP93 | S52 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N1G0 | ZNF687 | Y514 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N4V1 | MMGT1 | S109 | ochoa | ER membrane protein complex subunit 5 (Membrane magnesium transporter 1) (Transmembrane protein 32) | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (By similarity). May be involved in Mg(2+) transport (By similarity). {ECO:0000250|UniProtKB:Q8K273, ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}. |
| Q8N9N5 | BANP | S90 | ochoa | Protein BANP (BEN domain-containing protein 1) (Btg3-associated nuclear protein) (Scaffold/matrix-associated region-1-binding protein) | Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function (By similarity). Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels (PubMed:16166625). Promotes TP53 activation, which causes cell cycle arrest (By similarity). Plays a role in the regulation of alternative splicing (PubMed:26080397). Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10 (PubMed:26080397). {ECO:0000250|UniProtKB:Q8VBU8, ECO:0000269|PubMed:16166625, ECO:0000269|PubMed:26080397}. |
| Q8NCN4 | RNF169 | S472 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NE01 | CNNM3 | S599 | ochoa | Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3) | Probable metal transporter. {ECO:0000250}. |
| Q8NI27 | THOC2 | S1448 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TD55 | PLEKHO2 | S439 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TDW5 | SYTL5 | S306 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8TDY2 | RB1CC1 | S1160 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TE02 | ELP5 | S277 | ochoa | Elongator complex protein 5 (Dermal papilla-derived protein 6) (S-phase 2 protein) | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity). {ECO:0000250|UniProtKB:Q99L85, ECO:0000303|PubMed:29332244}. |
| Q8WTV1 | THAP3 | S122 | ochoa | THAP domain-containing protein 3 | Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. {ECO:0000269|PubMed:20200153}. |
| Q8WZA9 | IRGQ | S44 | ochoa | Immunity-related GTPase family Q protein | Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation (PubMed:39481378). Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation (PubMed:39481378). Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response (PubMed:39481378). In contrast to other members of the family, does not show GTPase activity (PubMed:39481378). {ECO:0000269|PubMed:39481378}. |
| Q92844 | TANK | S67 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q93034 | CUL5 | S128 | ochoa | Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1) | Core component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11384984, PubMed:15601820, PubMed:21199876, PubMed:21980433, PubMed:23897481, PubMed:25505247, PubMed:27910872, PubMed:32200094, PubMed:33268465, PubMed:35512830, PubMed:38418882). Acts a scaffold protein that contributes to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:11384984, PubMed:15601820, PubMed:33268465). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable SOCS box-containing substrate recognition component (PubMed:11384984, PubMed:15601820, PubMed:33268465). Acts as a key regulator of neuron positioning during cortex development: component of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (By similarity). ECS(SOCS1) seems to direct ubiquitination of JAK2 (PubMed:11384984). The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR (PubMed:21980433, PubMed:25505247). The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS (PubMed:38418882). ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine (PubMed:32200094). The ECS(ASB9) complex mediates ubiquitination and degradation of CKB (PubMed:33268465). As part of some ECS complex, promotes 'Lys-11'-linked ubiquitination and degradation of BTRC (PubMed:27910872). As part of a multisubunit ECS complex, polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). As part of the ECS(RAB40A) complex, mediates RHOU 'Lys-48'-linked ubiquitination and degradation, thus inhibiting focal adhesion disassembly during cell migration (PubMed:26598620). As part of the ECS(RAB40B) complex, mediates LIMA1/EPLIN and RAP2 ubiquitination, thereby regulating actin cytoskeleton dynamics and stress fiber formation during cell migration (PubMed:33999101, PubMed:35293963). May form a cell surface vasopressin receptor (PubMed:9037604). {ECO:0000250|UniProtKB:Q9D5V5, ECO:0000269|PubMed:11384984, ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:19920177, ECO:0000269|PubMed:21199876, ECO:0000269|PubMed:21980433, ECO:0000269|PubMed:23897481, ECO:0000269|PubMed:25505247, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:27910872, ECO:0000269|PubMed:32200094, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:33999101, ECO:0000269|PubMed:35293963, ECO:0000269|PubMed:35512830, ECO:0000269|PubMed:38418882, ECO:0000269|PubMed:9037604}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, CUL5 associates with HIV-1 Vif proteins and forms a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) that catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G (PubMed:16636053, PubMed:22190037). The complex can also ubiquitinate APOBEC3H to some extent (PubMed:37640699). {ECO:0000269|PubMed:16636053, ECO:0000269|PubMed:22190037, ECO:0000269|PubMed:37640699}.; FUNCTION: (Microbial infection) Seems to be involved in proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. {ECO:0000269|PubMed:12186903}. |
| Q969G9 | NKD1 | S169 | ochoa | Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}. |
| Q96A22 | C11orf52 | S85 | ochoa | Uncharacterized protein C11orf52 | None |
| Q96BU1 | S100PBP | S101 | ochoa | S100P-binding protein (S100P-binding protein Riken) | None |
| Q96C24 | SYTL4 | S211 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96EY4 | TMA16 | S138 | ochoa | Translation machinery-associated protein 16 | Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. {ECO:0000269|PubMed:32669547}. |
| Q96N46 | TTC14 | S546 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96PE3 | INPP4A | S255 | ochoa | Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity) (PubMed:30071275). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). {ECO:0000250|UniProtKB:Q62784, ECO:0000250|UniProtKB:Q9EPW0, ECO:0000269|PubMed:15716355, ECO:0000269|PubMed:20463662, ECO:0000269|PubMed:30071275}.; FUNCTION: [Isoform 4]: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3. {ECO:0000269|PubMed:9295334}. |
| Q96PU8 | QKI | S188 | ochoa | KH domain-containing RNA-binding protein QKI (Protein quaking) (Hqk) (HqkI) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (PubMed:22398723, PubMed:23630077, PubMed:25768908, PubMed:27029405, PubMed:31331967, PubMed:37379838). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development (PubMed:25768908, PubMed:31829086, PubMed:34428287, PubMed:37379838). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (PubMed:23630077). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons (PubMed:25768908). CircRNAs are produced by back-splicing circularization of pre-mRNAs (PubMed:25768908). Plays a central role in myelinization via 3 distinct mechanisms (PubMed:16641098). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation (By similarity). Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA (By similarity). Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation (By similarity). Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (PubMed:27029405). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts (By similarity). Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1 (By similarity). Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development (PubMed:31331967). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:16641098, ECO:0000269|PubMed:22398723, ECO:0000269|PubMed:23630077, ECO:0000269|PubMed:25768908, ECO:0000269|PubMed:27029405, ECO:0000269|PubMed:31331967, ECO:0000269|PubMed:31829086, ECO:0000269|PubMed:34428287, ECO:0000269|PubMed:37379838}.; FUNCTION: [Isoform QKI5]: Nuclear isoform that acts as an indirect regulator of mRNA splicing (By similarity). Regulates mRNA splicing of MAG pre-mRNA by inhibiting translation of HNRNPA1 mRNA, thereby preventing MAG exon 12 alternative splicing (By similarity). Involved in oligodendrocyte differentiation by promoting stabilization of SIRT2 mRNA (By similarity). Acts as a negative regulator of the interferon response by binding to MAVS mRNA, downregulating its expression (PubMed:31829086). Also inhibits the interferon response by binding to fibrinectin FN1 pre-mRNA, repressing EDA exon inclusion in FN1 (PubMed:34428287). Delays macrophage differentiation by binding to CSF1R mRNA, promoting its degradation (PubMed:22398723). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2, promoting SREBF2/SREBP2-dependent cholesterol biosynthesis (By similarity). SREBF2/SREBP2-dependent cholesterol biosynthesis participates to myelinization and is required for eye lens transparency (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:22398723, ECO:0000269|PubMed:31829086, ECO:0000269|PubMed:34428287}.; FUNCTION: [Isoform QKI6]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (PubMed:37379838). Acts as a translational repressor for HNRNPA1 and GLI1 (By similarity). Translation inhibition of HNRNPA1 during oligodendrocyte differentiation prevents inclusion of exon 12 in MAG pre-mRNA splicing (By similarity). Involved in astrocyte differentiation by regulating translation of target mRNAs (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:37379838}.; FUNCTION: [Isoform QKI7]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (PubMed:37379838). Acts as a negative regulator of angiogenesis by binding to mRNAs encoding CDH5, NLGN1 and TNFAIP6, promoting their degradation (PubMed:32732889). Can also induce apoptosis in the cytoplasm (By similarity). Heterodimerization with other isoforms results in nuclear translocation of isoform QKI7 and suppression of apoptosis (By similarity). Also binds some microRNAs: promotes stabilitation of miR-122 by mediating recruitment of poly(A) RNA polymerase TENT2, leading to 3' adenylation and stabilization of miR-122 (PubMed:31792053). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:31792053, ECO:0000269|PubMed:32732889, ECO:0000269|PubMed:37379838}. |
| Q96QT4 | TRPM7 | S1660 | psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q99666 | RGPD5 | S1481 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99683 | MAP3K5 | T1326 | psp | Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}. |
| Q99698 | LYST | S2627 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q99983 | OMD | S226 | ochoa | Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD) | May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. {ECO:0000250|UniProtKB:O77742}. |
| Q99983 | OMD | S244 | ochoa | Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD) | May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. {ECO:0000250|UniProtKB:O77742}. |
| Q9BQG0 | MYBBP1A | S1290 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BVJ6 | UTP14A | S445 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BW71 | HIRIP3 | S502 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BX66 | SORBS1 | S684 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BXB5 | OSBPL10 | S326 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9H019 | MTFR1L | S41 | ochoa | Mitochondrial fission regulator 1-like | Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels. {ECO:0000269|PubMed:36367943}. |
| Q9H4G4 | GLIPR2 | S55 | ochoa | Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) | None |
| Q9H6U6 | BCAS3 | S157 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H7D7 | WDR26 | S123 | ochoa | WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2) | G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:26895380, PubMed:27098453). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Also protects cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity). {ECO:0000250|UniProtKB:F1LTR1, ECO:0000269|PubMed:15378603, ECO:0000269|PubMed:19446606, ECO:0000269|PubMed:23625927, ECO:0000269|PubMed:26895380, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:29911972}. |
| Q9H814 | PHAX | S350 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9HCH5 | SYTL2 | S335 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCN4 | GPN1 | S301 | ochoa | GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1) | Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:21768307, ECO:0000305|PubMed:11058119}. |
| Q9NQG5 | RPRD1B | S134 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}. |
| Q9NR30 | DDX21 | S592 | ochoa | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NRA8 | EIF4ENIF1 | S454 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NU22 | MDN1 | S1754 | ochoa | Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein) | Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). {ECO:0000250|UniProtKB:Q12019, ECO:0000269|PubMed:27814492}. |
| Q9NUE0 | ZDHHC18 | S171 | ochoa | Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:27481942, ECO:0000269|PubMed:35438208}. |
| Q9NVM9 | INTS13 | S623 | ochoa | Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:32647223). Within the integrator complex, INTS13 is part of the integrator tail module and acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386, PubMed:38906142). At prophase, mediates recruitment of cytoplasmic dynein to the nuclear envelope, a step important for proper centrosome-nucleus coupling (PubMed:23097494, PubMed:23904267). At G2/M phase, may be required for proper spindle formation and execution of cytokinesis (PubMed:23097494, PubMed:23904267). {ECO:0000269|PubMed:23097494, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:32647223, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386, ECO:0000269|PubMed:38906142}. |
| Q9NZ71 | RTEL1 | S847 | ochoa | Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) | A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}. |
| Q9NZZ3 | CHMP5 | S26 | ochoa | Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60) | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) (PubMed:14519844). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release (PubMed:14519844). {ECO:0000269|PubMed:14519844}. |
| Q9P253 | VPS18 | S689 | ochoa | Vacuolar protein sorting-associated protein 18 homolog (hVPS18) | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). {ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25783203}. |
| Q9P2B4 | CTTNBP2NL | S488 | ochoa | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| Q9UBS8 | RNF14 | S348 | ochoa | E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) | E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Mediates ubiquitination of EEF1A1/eEF1A and ETF1/eRF1 translation factors on stalled ribosomes, leading to their degradation (PubMed:36638793, PubMed:37651229). Also catalyzes ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome (PubMed:37951215, PubMed:37951216). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (PubMed:23449499). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (PubMed:19345326). {ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:23449499, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q9UJF2 | RASAL2 | S758 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UKL3 | CASP8AP2 | S1326 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKL3 | CASP8AP2 | S1674 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKX2 | MYH2 | S1267 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULD4 | BRPF3 | S740 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9ULF5 | SLC39A10 | S573 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9ULH0 | KIDINS220 | S1623 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULL1 | PLEKHG1 | S930 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9ULL8 | SHROOM4 | S1019 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9UQ35 | SRRM2 | S1348 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQR1 | ZNF148 | S438 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9Y2I6 | NINL | S448 | psp | Ninein-like protein | Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}. |
| Q9Y2J2 | EPB41L3 | S91 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| O00141 | SGK1 | S252 | Sugiyama | Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1. {ECO:0000269|PubMed:11154281, ECO:0000269|PubMed:11410590, ECO:0000269|PubMed:11696533, ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:12650886, ECO:0000269|PubMed:12761204, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:14623317, ECO:0000269|PubMed:14706641, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15044175, ECO:0000269|PubMed:15234985, ECO:0000269|PubMed:15319523, ECO:0000269|PubMed:15496163, ECO:0000269|PubMed:15733869, ECO:0000269|PubMed:15737648, ECO:0000269|PubMed:15845389, ECO:0000269|PubMed:15888551, ECO:0000269|PubMed:16036218, ECO:0000269|PubMed:16443776, ECO:0000269|PubMed:16982696, ECO:0000269|PubMed:17382906, ECO:0000269|PubMed:18005662, ECO:0000269|PubMed:18304449, ECO:0000269|PubMed:18753299, ECO:0000269|PubMed:19447520, ECO:0000269|PubMed:19756449, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:20730100, ECO:0000269|PubMed:21865597}. |
| P08238 | HSP90AB1 | S383 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| Q9Y4L1 | HYOU1 | S763 | Sugiyama | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
| P06733 | ENO1 | S349 | Sugiyama | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| O43172 | PRPF4 | S298 | Sugiyama | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:28781166}. |
| O75330 | HMMR | S344 | Sugiyama | Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168) | Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). {ECO:0000250|UniProtKB:Q00547}. |
| O43615 | TIMM44 | T106 | Sugiyama | Mitochondrial import inner membrane translocase subunit TIM44 | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250|UniProtKB:O35857, ECO:0000250|UniProtKB:Q01852}. |
| P63241 | EIF5A | S100 | Sugiyama | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Also regulates TNF-alpha-mediated apoptosis (PubMed:15452064, PubMed:17187778). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (PubMed:29712776). {ECO:0000250|UniProtKB:P23301, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499, ECO:0000269|PubMed:29712776, ECO:0000269|PubMed:33547280}.; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:8253832}. |
| O95721 | SNAP29 | S204 | Sugiyama | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
| P00519 | ABL1 | S1106 | Sugiyama | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P06493 | CDK1 | S46 | Sugiyama | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}. |
| P33176 | KIF5B | S717 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P07384 | CAPN1 | S256 | EPSD|PSP | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}. |
| Q15084 | PDIA6 | S205 | Sugiyama | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| P25788 | PSMA3 | S97 | Sugiyama | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| Q3V6T2 | CCDC88A | S1172 | Sugiyama | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| P51957 | NEK4 | S379 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P51957 | NEK4 | S467 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| Q12874 | SF3A3 | S76 | Sugiyama | Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:8022796}. |
| Q14164 | IKBKE | S695 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| P50542 | PEX5 | S279 | Sugiyama | Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) | Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:11101887, PubMed:11336669, PubMed:12456682, PubMed:16314507, PubMed:17157249, PubMed:17428317, PubMed:21976670, PubMed:26344566, PubMed:7706321, PubMed:7719337, PubMed:7790377). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:12456682, PubMed:17157249, PubMed:21976670, PubMed:26344566). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:11336669, PubMed:24662292). {ECO:0000269|PubMed:11101887, ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:12456682, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:17157249, ECO:0000269|PubMed:17428317, ECO:0000269|PubMed:21976670, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:7706321, ECO:0000269|PubMed:7719337, ECO:0000269|PubMed:7790377}.; FUNCTION: [Isoform 1]: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed:11336669, PubMed:11546814, PubMed:25538232, PubMed:33389129, PubMed:9668159). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (PubMed:25538232). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 (PubMed:25538232). {ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:25538232, ECO:0000269|PubMed:33389129, ECO:0000269|PubMed:9668159}.; FUNCTION: [Isoform 2]: Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. {ECO:0000269|PubMed:11546814}. |
| Q9NQP4 | PFDN4 | S103 | Sugiyama | Prefoldin subunit 4 (Protein C-1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q09028 | RBBP4 | S159 | Sugiyama | Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152, ECO:0000269|PubMed:9150135}. |
| P13674 | P4HA1 | S395 | Sugiyama | Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) | Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}. |
| P17275 | JUNB | S312 | Sugiyama | Transcription factor JunB (Transcription factor AP-1 subunit JunB) | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P09450}. |
| Q9H0H5 | RACGAP1 | S410 | ELM|iPTMNet|EPSD | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| P83436 | COG7 | S559 | Sugiyama | Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7) | Required for normal Golgi function. {ECO:0000269|PubMed:11980916}. |
| Q15075 | EEA1 | S76 | Sugiyama | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| P09960 | LTA4H | S496 | Sugiyama | Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:18804029, PubMed:20813919). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}. |
| P15924 | DSP | S63 | Sugiyama | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.214660e-08 | 7.085 |
| R-HSA-1538133 | G0 and Early G1 | 2.875496e-07 | 6.541 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.419614e-07 | 6.130 |
| R-HSA-69275 | G2/M Transition | 1.968679e-06 | 5.706 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.159254e-06 | 5.287 |
| R-HSA-69205 | G1/S-Specific Transcription | 8.500116e-06 | 5.071 |
| R-HSA-69206 | G1/S Transition | 2.448058e-05 | 4.611 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.285729e-05 | 4.641 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.281282e-05 | 4.484 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.281282e-05 | 4.484 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 6.528371e-05 | 4.185 |
| R-HSA-1640170 | Cell Cycle | 7.508738e-05 | 4.124 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.981308e-04 | 3.703 |
| R-HSA-68911 | G2 Phase | 2.262583e-04 | 3.645 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.480318e-04 | 3.605 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.312792e-04 | 3.636 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.975583e-04 | 3.526 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.394147e-04 | 3.469 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.942736e-04 | 3.404 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 6.041587e-04 | 3.219 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 8.367536e-04 | 3.077 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.043844e-03 | 2.981 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.217595e-03 | 2.914 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.217595e-03 | 2.914 |
| R-HSA-199991 | Membrane Trafficking | 1.635363e-03 | 2.786 |
| R-HSA-69242 | S Phase | 1.837772e-03 | 2.736 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.022406e-03 | 2.694 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.022406e-03 | 2.694 |
| R-HSA-180897 | Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabiliza... | 2.036159e-03 | 2.691 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.167192e-03 | 2.664 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 2.425262e-03 | 2.615 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.347691e-03 | 2.629 |
| R-HSA-9842663 | Signaling by LTK | 2.425262e-03 | 2.615 |
| R-HSA-380287 | Centrosome maturation | 2.645917e-03 | 2.577 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.874444e-03 | 2.541 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.874444e-03 | 2.541 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.581636e-03 | 2.446 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.722682e-03 | 2.429 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.078523e-03 | 2.389 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.351323e-03 | 2.361 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 4.515931e-03 | 2.345 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.512008e-03 | 2.346 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 5.869214e-03 | 2.231 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 5.869214e-03 | 2.231 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.592194e-03 | 2.252 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.154591e-03 | 2.211 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 5.165833e-03 | 2.287 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.068329e-03 | 2.295 |
| R-HSA-6798695 | Neutrophil degranulation | 5.838625e-03 | 2.234 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.132631e-03 | 2.290 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.526586e-03 | 2.258 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 6.204633e-03 | 2.207 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.224449e-03 | 2.206 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 6.224449e-03 | 2.206 |
| R-HSA-156711 | Polo-like kinase mediated events | 6.627186e-03 | 2.179 |
| R-HSA-166520 | Signaling by NTRKs | 6.466877e-03 | 2.189 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 7.440761e-03 | 2.128 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 7.779125e-03 | 2.109 |
| R-HSA-176417 | Phosphorylation of Emi1 | 7.802766e-03 | 2.108 |
| R-HSA-5617833 | Cilium Assembly | 8.049071e-03 | 2.094 |
| R-HSA-162906 | HIV Infection | 8.072298e-03 | 2.093 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 9.770425e-03 | 2.010 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 9.238309e-03 | 2.034 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 9.238309e-03 | 2.034 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.013931e-02 | 1.994 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.013931e-02 | 1.994 |
| R-HSA-6811438 | Intra-Golgi traffic | 8.962489e-03 | 2.048 |
| R-HSA-69481 | G2/M Checkpoints | 9.420228e-03 | 2.026 |
| R-HSA-373753 | Nephrin family interactions | 8.310859e-03 | 2.080 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.592016e-03 | 2.018 |
| R-HSA-1500931 | Cell-Cell communication | 1.001176e-02 | 1.999 |
| R-HSA-9006936 | Signaling by TGFB family members | 9.592016e-03 | 2.018 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 9.204253e-03 | 2.036 |
| R-HSA-109581 | Apoptosis | 1.020631e-02 | 1.991 |
| R-HSA-69236 | G1 Phase | 1.094811e-02 | 1.961 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.094811e-02 | 1.961 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.237178e-02 | 1.908 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.193423e-02 | 1.923 |
| R-HSA-75153 | Apoptotic execution phase | 1.241759e-02 | 1.906 |
| R-HSA-5357801 | Programmed Cell Death | 1.253877e-02 | 1.902 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.319734e-02 | 1.880 |
| R-HSA-168256 | Immune System | 1.397923e-02 | 1.855 |
| R-HSA-196025 | Formation of annular gap junctions | 1.428737e-02 | 1.845 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.428737e-02 | 1.845 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.572124e-02 | 1.804 |
| R-HSA-9613354 | Lipophagy | 1.682318e-02 | 1.774 |
| R-HSA-190873 | Gap junction degradation | 1.682318e-02 | 1.774 |
| R-HSA-204626 | Hypusine synthesis from eIF5A-lysine | 1.682318e-02 | 1.774 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.756125e-02 | 1.755 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.756125e-02 | 1.755 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.604326e-02 | 1.795 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.756125e-02 | 1.755 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.682318e-02 | 1.774 |
| R-HSA-168255 | Influenza Infection | 1.712010e-02 | 1.766 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.585649e-02 | 1.800 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.852945e-02 | 1.732 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.953517e-02 | 1.709 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.056368e-02 | 1.687 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.163023e-02 | 1.665 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.953517e-02 | 1.709 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.163023e-02 | 1.665 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.163023e-02 | 1.665 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.179138e-02 | 1.662 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.179138e-02 | 1.662 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.195196e-02 | 1.659 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 2.241701e-02 | 1.649 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.338175e-02 | 1.631 |
| R-HSA-9663891 | Selective autophagy | 2.243162e-02 | 1.649 |
| R-HSA-9612973 | Autophagy | 2.542554e-02 | 1.595 |
| R-HSA-68877 | Mitotic Prometaphase | 2.445434e-02 | 1.612 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.273007e-02 | 1.643 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.503351e-02 | 1.601 |
| R-HSA-210747 | Regulation of gene expression in early pancreatic precursor cells | 2.241701e-02 | 1.649 |
| R-HSA-422475 | Axon guidance | 2.488173e-02 | 1.604 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.273007e-02 | 1.643 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.386784e-02 | 1.622 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 2.546254e-02 | 1.594 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.674659e-02 | 1.573 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.704774e-02 | 1.568 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.866573e-02 | 1.543 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.866573e-02 | 1.543 |
| R-HSA-1299344 | TWIK-related spinal cord K+ channel (TRESK) | 3.213895e-02 | 1.493 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 3.213895e-02 | 1.493 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.225225e-02 | 1.491 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.225225e-02 | 1.491 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.420889e-02 | 1.466 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.003908e-02 | 1.522 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.035615e-02 | 1.518 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.008744e-02 | 1.522 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 3.202072e-02 | 1.495 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.420889e-02 | 1.466 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.225225e-02 | 1.491 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.126203e-02 | 1.505 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.212308e-02 | 1.493 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.420889e-02 | 1.466 |
| R-HSA-373755 | Semaphorin interactions | 3.003908e-02 | 1.522 |
| R-HSA-168249 | Innate Immune System | 3.475984e-02 | 1.459 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.707567e-02 | 1.431 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3.916338e-02 | 1.407 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.916338e-02 | 1.407 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.984294e-02 | 1.400 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.984294e-02 | 1.400 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 4.782044e-02 | 1.320 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 4.782044e-02 | 1.320 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.705460e-02 | 1.327 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.498235e-02 | 1.347 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 4.782044e-02 | 1.320 |
| R-HSA-1632852 | Macroautophagy | 4.675644e-02 | 1.330 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.675644e-02 | 1.330 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.072530e-02 | 1.390 |
| R-HSA-9657689 | Defective SERPING1 causes hereditary angioedema | 4.782044e-02 | 1.320 |
| R-HSA-69239 | Synthesis of DNA | 4.705460e-02 | 1.327 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.488830e-02 | 1.348 |
| R-HSA-9651496 | Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 4.684645e-02 | 1.329 |
| R-HSA-9675108 | Nervous system development | 4.055748e-02 | 1.392 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.048610e-02 | 1.393 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.043887e-02 | 1.393 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.327352e-02 | 1.364 |
| R-HSA-8852135 | Protein ubiquitination | 4.838889e-02 | 1.315 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 6.324880e-02 | 1.199 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 6.324880e-02 | 1.199 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 6.324880e-02 | 1.199 |
| R-HSA-5578997 | Defective AHCY causes HMAHCHD | 6.324880e-02 | 1.199 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 6.324880e-02 | 1.199 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 6.324880e-02 | 1.199 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 6.324880e-02 | 1.199 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 6.324880e-02 | 1.199 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 6.324880e-02 | 1.199 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 6.324880e-02 | 1.199 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 6.324880e-02 | 1.199 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 6.324880e-02 | 1.199 |
| R-HSA-1296067 | Potassium transport channels | 6.324880e-02 | 1.199 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 9.336236e-02 | 1.030 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 9.336236e-02 | 1.030 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 1.080555e-01 | 0.966 |
| R-HSA-9673221 | Defective F9 activation | 1.080555e-01 | 0.966 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 1.225114e-01 | 0.912 |
| R-HSA-3656244 | Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | 1.367339e-01 | 0.864 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.367339e-01 | 0.864 |
| R-HSA-3656243 | Defective ST3GAL3 causes MCT12 and EIEE15 | 1.367339e-01 | 0.864 |
| R-HSA-3656225 | Defective CHST6 causes MCDC1 | 1.367339e-01 | 0.864 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.507268e-01 | 0.822 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.507268e-01 | 0.822 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.507268e-01 | 0.822 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 5.929344e-02 | 1.227 |
| R-HSA-170984 | ARMS-mediated activation | 1.780382e-01 | 0.749 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.780382e-01 | 0.749 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 6.814916e-02 | 1.167 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.913640e-01 | 0.718 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 7.273038e-02 | 1.138 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 8.703493e-02 | 1.060 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 8.703493e-02 | 1.060 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 9.197613e-02 | 1.036 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 1.020941e-01 | 0.991 |
| R-HSA-167287 | HIV elongation arrest and recovery | 1.072633e-01 | 0.970 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 1.072633e-01 | 0.970 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.125009e-01 | 0.949 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.178036e-01 | 0.929 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.226393e-02 | 1.206 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.231678e-01 | 0.910 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.231678e-01 | 0.910 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.340675e-01 | 0.873 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.340675e-01 | 0.873 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.395964e-01 | 0.855 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 1.395964e-01 | 0.855 |
| R-HSA-72649 | Translation initiation complex formation | 8.227948e-02 | 1.085 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 8.844838e-02 | 1.053 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.564630e-01 | 0.806 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.736886e-01 | 0.760 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.794976e-01 | 0.746 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 1.794976e-01 | 0.746 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.184424e-01 | 0.926 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.148818e-01 | 0.668 |
| R-HSA-774815 | Nucleosome assembly | 2.148818e-01 | 0.668 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.477991e-01 | 0.830 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.328136e-01 | 0.633 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.672236e-01 | 0.777 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.832689e-01 | 0.737 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.249661e-01 | 0.648 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.292373e-01 | 0.640 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.464663e-01 | 0.608 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.508057e-01 | 0.601 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 5.702004e-02 | 1.244 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 5.702004e-02 | 1.244 |
| R-HSA-9646399 | Aggrephagy | 1.794976e-01 | 0.746 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 5.448069e-02 | 1.264 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.171654e-02 | 1.038 |
| R-HSA-9664873 | Pexophagy | 1.913640e-01 | 0.718 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.080495e-01 | 0.682 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.340675e-01 | 0.873 |
| R-HSA-156902 | Peptide chain elongation | 2.122518e-01 | 0.673 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.178036e-01 | 0.929 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.194985e-01 | 0.923 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.780382e-01 | 0.749 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.451740e-01 | 0.838 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.402487e-01 | 0.853 |
| R-HSA-171319 | Telomere Extension By Telomerase | 1.072633e-01 | 0.970 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 7.926772e-02 | 1.101 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.650843e-01 | 0.782 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.244093e-01 | 0.905 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.178036e-01 | 0.929 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 9.978409e-02 | 1.001 |
| R-HSA-9907900 | Proteasome assembly | 2.089328e-01 | 0.680 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.650843e-01 | 0.782 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 8.703493e-02 | 1.060 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.395964e-01 | 0.855 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 9.699714e-02 | 1.013 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.225114e-01 | 0.912 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.508057e-01 | 0.601 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.527797e-01 | 0.816 |
| R-HSA-391251 | Protein folding | 2.335237e-01 | 0.632 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.955613e-01 | 0.709 |
| R-HSA-177929 | Signaling by EGFR | 8.844838e-02 | 1.053 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 5.502812e-02 | 1.259 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.379200e-01 | 0.860 |
| R-HSA-5693538 | Homology Directed Repair | 1.713667e-01 | 0.766 |
| R-HSA-9657688 | Defective factor XII causes hereditary angioedema | 6.324880e-02 | 1.199 |
| R-HSA-168277 | Influenza Virus Induced Apoptosis | 6.324880e-02 | 1.199 |
| R-HSA-417973 | Adenosine P1 receptors | 7.842810e-02 | 1.106 |
| R-HSA-187024 | NGF-independant TRKA activation | 1.225114e-01 | 0.912 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 1.225114e-01 | 0.912 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 1.507268e-01 | 0.822 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 5.502812e-02 | 1.259 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.913640e-01 | 0.718 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.913640e-01 | 0.718 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 1.913640e-01 | 0.718 |
| R-HSA-192905 | vRNP Assembly | 2.044746e-01 | 0.689 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.300638e-01 | 0.638 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.020941e-01 | 0.991 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.231678e-01 | 0.910 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.451740e-01 | 0.838 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 8.227948e-02 | 1.085 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 1.564630e-01 | 0.806 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.621687e-01 | 0.790 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.148818e-01 | 0.668 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.208462e-01 | 0.656 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 1.125009e-01 | 0.949 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.257265e-01 | 0.901 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 1.621687e-01 | 0.790 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.164726e-01 | 0.665 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.121031e-01 | 0.950 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.335237e-01 | 0.632 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.353241e-01 | 0.869 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.378245e-01 | 0.624 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 1.080555e-01 | 0.966 |
| R-HSA-74749 | Signal attenuation | 1.913640e-01 | 0.718 |
| R-HSA-3371511 | HSF1 activation | 1.564630e-01 | 0.806 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 6.814916e-02 | 1.167 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 9.336236e-02 | 1.030 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.507268e-01 | 0.822 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 1.913640e-01 | 0.718 |
| R-HSA-8851805 | MET activates RAS signaling | 2.300638e-01 | 0.638 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 7.630548e-02 | 1.117 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.395964e-01 | 0.855 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 1.679115e-01 | 0.775 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.970901e-01 | 0.705 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.243097e-01 | 0.649 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 9.160389e-02 | 1.038 |
| R-HSA-5689603 | UCH proteinases | 1.593642e-01 | 0.798 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.346518e-02 | 1.197 |
| R-HSA-983189 | Kinesins | 1.013447e-01 | 0.994 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.631132e-02 | 1.178 |
| R-HSA-8983432 | Interleukin-15 signaling | 2.300638e-01 | 0.638 |
| R-HSA-187687 | Signalling to ERKs | 1.507972e-01 | 0.822 |
| R-HSA-69306 | DNA Replication | 1.502053e-01 | 0.823 |
| R-HSA-73886 | Chromosome Maintenance | 7.220259e-02 | 1.141 |
| R-HSA-380095 | Tachykinin receptors bind tachykinins | 7.842810e-02 | 1.106 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 1.644937e-01 | 0.784 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 2.044746e-01 | 0.689 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 2.173734e-01 | 0.663 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.961467e-02 | 1.225 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.285902e-01 | 0.891 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.507972e-01 | 0.822 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 9.480568e-02 | 1.023 |
| R-HSA-194441 | Metabolism of non-coding RNA | 9.805291e-02 | 1.009 |
| R-HSA-191859 | snRNP Assembly | 9.805291e-02 | 1.009 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.912007e-01 | 0.719 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.912007e-01 | 0.719 |
| R-HSA-180786 | Extension of Telomeres | 9.805291e-02 | 1.009 |
| R-HSA-72312 | rRNA processing | 2.320854e-01 | 0.634 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.577756e-02 | 1.120 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.234577e-01 | 0.908 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 8.703493e-02 | 1.060 |
| R-HSA-2428924 | IGF1R signaling cascade | 1.149407e-01 | 0.940 |
| R-HSA-68886 | M Phase | 6.899253e-02 | 1.161 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.180522e-01 | 0.661 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.340675e-01 | 0.873 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.451740e-01 | 0.838 |
| R-HSA-4641258 | Degradation of DVL | 1.621687e-01 | 0.790 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.736886e-01 | 0.760 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.912007e-01 | 0.719 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.340675e-01 | 0.873 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.154636e-01 | 0.938 |
| R-HSA-114608 | Platelet degranulation | 8.512669e-02 | 1.070 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 1.184424e-01 | 0.926 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.367339e-01 | 0.864 |
| R-HSA-187015 | Activation of TRKA receptors | 1.507268e-01 | 0.822 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.644937e-01 | 0.784 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.780382e-01 | 0.749 |
| R-HSA-9668250 | Defective factor IX causes hemophilia B | 1.913640e-01 | 0.718 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.913640e-01 | 0.718 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.173734e-01 | 0.663 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.020941e-01 | 0.991 |
| R-HSA-445355 | Smooth Muscle Contraction | 7.926772e-02 | 1.101 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.564630e-01 | 0.806 |
| R-HSA-4641257 | Degradation of AXIN | 1.621687e-01 | 0.790 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.621687e-01 | 0.790 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.794976e-01 | 0.746 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.853358e-01 | 0.732 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.508317e-01 | 0.601 |
| R-HSA-68882 | Mitotic Anaphase | 1.912757e-01 | 0.718 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.937413e-01 | 0.713 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.878956e-02 | 1.005 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.702004e-02 | 1.244 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.199725e-02 | 1.284 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 9.918394e-02 | 1.004 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 7.273038e-02 | 1.138 |
| R-HSA-73894 | DNA Repair | 1.724062e-01 | 0.763 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.702004e-02 | 1.244 |
| R-HSA-8953854 | Metabolism of RNA | 1.102161e-01 | 0.958 |
| R-HSA-3371556 | Cellular response to heat stress | 1.809437e-01 | 0.742 |
| R-HSA-162587 | HIV Life Cycle | 1.604941e-01 | 0.795 |
| R-HSA-8964011 | HDL clearance | 1.367339e-01 | 0.864 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 6.366866e-02 | 1.196 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 2.044746e-01 | 0.689 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.425493e-01 | 0.615 |
| R-HSA-9634597 | GPER1 signaling | 6.496716e-02 | 1.187 |
| R-HSA-9766229 | Degradation of CDH1 | 6.772365e-02 | 1.169 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.395964e-01 | 0.855 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.451740e-01 | 0.838 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.451740e-01 | 0.838 |
| R-HSA-169911 | Regulation of Apoptosis | 1.507972e-01 | 0.822 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.679115e-01 | 0.775 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.958565e-02 | 1.157 |
| R-HSA-3371568 | Attenuation phase | 1.794976e-01 | 0.746 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.912007e-01 | 0.719 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.912007e-01 | 0.719 |
| R-HSA-190828 | Gap junction trafficking | 2.089328e-01 | 0.680 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.208462e-01 | 0.656 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.914410e-01 | 0.718 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.751942e-01 | 0.756 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 1.125009e-01 | 0.949 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.398177e-01 | 0.620 |
| R-HSA-2559583 | Cellular Senescence | 2.275261e-01 | 0.643 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 9.197613e-02 | 1.036 |
| R-HSA-5654736 | Signaling by FGFR1 | 8.844838e-02 | 1.053 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 8.703493e-02 | 1.060 |
| R-HSA-8863678 | Neurodegenerative Diseases | 8.703493e-02 | 1.060 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 2.208462e-01 | 0.656 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 1.125009e-01 | 0.949 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 1.178036e-01 | 0.929 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 1.507972e-01 | 0.822 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.780382e-01 | 0.749 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 1.913640e-01 | 0.718 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 2.300638e-01 | 0.638 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.020941e-01 | 0.991 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.425493e-01 | 0.615 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 8.227948e-02 | 1.085 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 1.507972e-01 | 0.822 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 1.736886e-01 | 0.760 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.736886e-01 | 0.760 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.794976e-01 | 0.746 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.853358e-01 | 0.732 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 1.853358e-01 | 0.732 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.388126e-01 | 0.622 |
| R-HSA-4086400 | PCP/CE pathway | 1.672236e-01 | 0.777 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 1.564630e-01 | 0.806 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.129007e-01 | 0.672 |
| R-HSA-9659379 | Sensory processing of sound | 5.561796e-02 | 1.255 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.476783e-01 | 0.831 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 6.366866e-02 | 1.196 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.178036e-01 | 0.929 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.736886e-01 | 0.760 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.030015e-01 | 0.693 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.148818e-01 | 0.668 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.042763e-01 | 0.690 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 6.772365e-02 | 1.169 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 6.772365e-02 | 1.169 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.122518e-01 | 0.673 |
| R-HSA-8848021 | Signaling by PTK6 | 1.114791e-01 | 0.953 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.114791e-01 | 0.953 |
| R-HSA-8939211 | ESR-mediated signaling | 1.305790e-01 | 0.884 |
| R-HSA-9671793 | Diseases of hemostasis | 5.929344e-02 | 1.227 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.460747e-02 | 1.263 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 6.496716e-02 | 1.187 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.148818e-01 | 0.668 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.487541e-02 | 1.188 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.581169e-01 | 0.801 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.038664e-01 | 0.691 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.780382e-01 | 0.749 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 2.044746e-01 | 0.689 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 1.125009e-01 | 0.949 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.794976e-01 | 0.746 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.268242e-01 | 0.644 |
| R-HSA-2262752 | Cellular responses to stress | 5.605704e-02 | 1.251 |
| R-HSA-9031628 | NGF-stimulated transcription | 2.328136e-01 | 0.633 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.234577e-01 | 0.908 |
| R-HSA-418990 | Adherens junctions interactions | 9.769715e-02 | 1.010 |
| R-HSA-9020558 | Interleukin-2 signaling | 2.044746e-01 | 0.689 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 1.020941e-01 | 0.991 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.507972e-01 | 0.822 |
| R-HSA-421270 | Cell-cell junction organization | 1.579195e-01 | 0.802 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.780382e-01 | 0.749 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 7.273038e-02 | 1.138 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 2.425493e-01 | 0.615 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.508317e-01 | 0.601 |
| R-HSA-9837999 | Mitochondrial protein degradation | 2.421389e-01 | 0.616 |
| R-HSA-446728 | Cell junction organization | 5.800476e-02 | 1.237 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.208462e-01 | 0.656 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 5.502812e-02 | 1.259 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 1.873432e-01 | 0.727 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.416639e-01 | 0.617 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.041531e-01 | 0.982 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.508317e-01 | 0.601 |
| R-HSA-449147 | Signaling by Interleukins | 1.746369e-01 | 0.758 |
| R-HSA-8982491 | Glycogen metabolism | 1.794976e-01 | 0.746 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 9.197613e-02 | 1.036 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.231678e-01 | 0.910 |
| R-HSA-186712 | Regulation of beta-cell development | 9.805291e-02 | 1.009 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.127786e-01 | 0.948 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 1.395964e-01 | 0.855 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.527507e-01 | 0.816 |
| R-HSA-8983711 | OAS antiviral response | 2.300638e-01 | 0.638 |
| R-HSA-69541 | Stabilization of p53 | 1.736886e-01 | 0.760 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.508317e-01 | 0.601 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.839530e-01 | 0.735 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 1.020941e-01 | 0.991 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.745390e-01 | 0.758 |
| R-HSA-9824272 | Somitogenesis | 2.148818e-01 | 0.668 |
| R-HSA-1059683 | Interleukin-6 signaling | 2.425493e-01 | 0.615 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.955613e-01 | 0.709 |
| R-HSA-201556 | Signaling by ALK | 1.736886e-01 | 0.760 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.030015e-01 | 0.693 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.426797e-01 | 0.846 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.293010e-01 | 0.888 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.336589e-02 | 1.079 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 1.736886e-01 | 0.760 |
| R-HSA-392499 | Metabolism of proteins | 2.520372e-01 | 0.599 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.540926e-01 | 0.595 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 2.548330e-01 | 0.594 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.548330e-01 | 0.594 |
| R-HSA-9018681 | Biosynthesis of protectins | 2.548330e-01 | 0.594 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.548330e-01 | 0.594 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 2.548330e-01 | 0.594 |
| R-HSA-9023661 | Biosynthesis of E-series 18(R)-resolvins | 2.548330e-01 | 0.594 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.548330e-01 | 0.594 |
| R-HSA-435354 | Zinc transporters | 2.548330e-01 | 0.594 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.551565e-01 | 0.593 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.551565e-01 | 0.593 |
| R-HSA-9664407 | Parasite infection | 2.557623e-01 | 0.592 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.557623e-01 | 0.592 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.557623e-01 | 0.592 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 2.568483e-01 | 0.590 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.568483e-01 | 0.590 |
| R-HSA-157579 | Telomere Maintenance | 2.595179e-01 | 0.586 |
| R-HSA-1643685 | Disease | 2.616774e-01 | 0.582 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.628674e-01 | 0.580 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 2.628674e-01 | 0.580 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.628674e-01 | 0.580 |
| R-HSA-597592 | Post-translational protein modification | 2.630362e-01 | 0.580 |
| R-HSA-190236 | Signaling by FGFR | 2.638892e-01 | 0.579 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.669183e-01 | 0.574 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.669183e-01 | 0.574 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.669183e-01 | 0.574 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.669183e-01 | 0.574 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.669183e-01 | 0.574 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.669183e-01 | 0.574 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.669183e-01 | 0.574 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.669183e-01 | 0.574 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.669183e-01 | 0.574 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.669183e-01 | 0.574 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.669183e-01 | 0.574 |
| R-HSA-3214847 | HATs acetylate histones | 2.682697e-01 | 0.571 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.698985e-01 | 0.569 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.700232e-01 | 0.569 |
| R-HSA-70171 | Glycolysis | 2.726586e-01 | 0.564 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.770552e-01 | 0.557 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.788082e-01 | 0.555 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 2.788082e-01 | 0.555 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.788082e-01 | 0.555 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 2.788082e-01 | 0.555 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.788082e-01 | 0.555 |
| R-HSA-169893 | Prolonged ERK activation events | 2.788082e-01 | 0.555 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.788082e-01 | 0.555 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.788082e-01 | 0.555 |
| R-HSA-75893 | TNF signaling | 2.809225e-01 | 0.551 |
| R-HSA-192823 | Viral mRNA Translation | 2.858689e-01 | 0.544 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.885707e-01 | 0.540 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.902846e-01 | 0.537 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.902846e-01 | 0.537 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.902846e-01 | 0.537 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 2.905061e-01 | 0.537 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.905061e-01 | 0.537 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.905061e-01 | 0.537 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.905061e-01 | 0.537 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.905061e-01 | 0.537 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.905061e-01 | 0.537 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.905061e-01 | 0.537 |
| R-HSA-5688426 | Deubiquitination | 2.948456e-01 | 0.530 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.948481e-01 | 0.530 |
| R-HSA-9033241 | Peroxisomal protein import | 2.989430e-01 | 0.524 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.991302e-01 | 0.524 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.020150e-01 | 0.520 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3.020150e-01 | 0.520 |
| R-HSA-9020265 | Biosynthesis of aspirin-triggered D-series resolvins | 3.020150e-01 | 0.520 |
| R-HSA-72172 | mRNA Splicing | 3.043074e-01 | 0.517 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.049355e-01 | 0.516 |
| R-HSA-351202 | Metabolism of polyamines | 3.049355e-01 | 0.516 |
| R-HSA-9609507 | Protein localization | 3.062197e-01 | 0.514 |
| R-HSA-211000 | Gene Silencing by RNA | 3.079906e-01 | 0.511 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.109185e-01 | 0.507 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.109185e-01 | 0.507 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.109185e-01 | 0.507 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.124247e-01 | 0.505 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.124247e-01 | 0.505 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.124247e-01 | 0.505 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.133378e-01 | 0.504 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 3.133378e-01 | 0.504 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.133378e-01 | 0.504 |
| R-HSA-210993 | Tie2 Signaling | 3.133378e-01 | 0.504 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 3.133378e-01 | 0.504 |
| R-HSA-1268020 | Mitochondrial protein import | 3.168909e-01 | 0.499 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.168909e-01 | 0.499 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.168909e-01 | 0.499 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.168909e-01 | 0.499 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.212976e-01 | 0.493 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.212976e-01 | 0.493 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.228514e-01 | 0.491 |
| R-HSA-912631 | Regulation of signaling by CBL | 3.244777e-01 | 0.489 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.244777e-01 | 0.489 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.244777e-01 | 0.489 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 3.244777e-01 | 0.489 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.244777e-01 | 0.489 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 3.244777e-01 | 0.489 |
| R-HSA-449836 | Other interleukin signaling | 3.244777e-01 | 0.489 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 3.244777e-01 | 0.489 |
| R-HSA-936837 | Ion transport by P-type ATPases | 3.287988e-01 | 0.483 |
| R-HSA-397014 | Muscle contraction | 3.297381e-01 | 0.482 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.301727e-01 | 0.481 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.301727e-01 | 0.481 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.301727e-01 | 0.481 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.347320e-01 | 0.475 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.354375e-01 | 0.474 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.354375e-01 | 0.474 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.354375e-01 | 0.474 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.354375e-01 | 0.474 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.354375e-01 | 0.474 |
| R-HSA-2022857 | Keratan sulfate degradation | 3.354375e-01 | 0.474 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.390452e-01 | 0.470 |
| R-HSA-9679506 | SARS-CoV Infections | 3.419176e-01 | 0.466 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.462201e-01 | 0.461 |
| R-HSA-167044 | Signalling to RAS | 3.462201e-01 | 0.461 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.462201e-01 | 0.461 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.462201e-01 | 0.461 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 3.462201e-01 | 0.461 |
| R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | 3.462201e-01 | 0.461 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.465515e-01 | 0.460 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.465673e-01 | 0.460 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.465673e-01 | 0.460 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.489672e-01 | 0.457 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.524356e-01 | 0.453 |
| R-HSA-167172 | Transcription of the HIV genome | 3.524356e-01 | 0.453 |
| R-HSA-373760 | L1CAM interactions | 3.567647e-01 | 0.448 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.568285e-01 | 0.448 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 3.568285e-01 | 0.448 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.568285e-01 | 0.448 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 3.583014e-01 | 0.446 |
| R-HSA-8951664 | Neddylation | 3.585828e-01 | 0.445 |
| R-HSA-70326 | Glucose metabolism | 3.611860e-01 | 0.442 |
| R-HSA-204005 | COPII-mediated vesicle transport | 3.641479e-01 | 0.439 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.641479e-01 | 0.439 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.641479e-01 | 0.439 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.641479e-01 | 0.439 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.641479e-01 | 0.439 |
| R-HSA-9018676 | Biosynthesis of D-series resolvins | 3.672653e-01 | 0.435 |
| R-HSA-8964038 | LDL clearance | 3.672653e-01 | 0.435 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 3.672653e-01 | 0.435 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.699741e-01 | 0.432 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 3.699741e-01 | 0.432 |
| R-HSA-68875 | Mitotic Prophase | 3.744212e-01 | 0.427 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.757793e-01 | 0.425 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.757793e-01 | 0.425 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.757793e-01 | 0.425 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.757793e-01 | 0.425 |
| R-HSA-418555 | G alpha (s) signalling events | 3.759990e-01 | 0.425 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.775335e-01 | 0.423 |
| R-HSA-8854691 | Interleukin-20 family signaling | 3.775335e-01 | 0.423 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 3.775335e-01 | 0.423 |
| R-HSA-200425 | Carnitine shuttle | 3.775335e-01 | 0.423 |
| R-HSA-9830674 | Formation of the ureteric bud | 3.775335e-01 | 0.423 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.788216e-01 | 0.422 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.788216e-01 | 0.422 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.815624e-01 | 0.418 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.833454e-01 | 0.416 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.873229e-01 | 0.412 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.873229e-01 | 0.412 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.873229e-01 | 0.412 |
| R-HSA-9013694 | Signaling by NOTCH4 | 3.873229e-01 | 0.412 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 3.873229e-01 | 0.412 |
| R-HSA-6783589 | Interleukin-6 family signaling | 3.876356e-01 | 0.412 |
| R-HSA-162582 | Signal Transduction | 3.885830e-01 | 0.411 |
| R-HSA-1266738 | Developmental Biology | 3.906196e-01 | 0.408 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.906822e-01 | 0.408 |
| R-HSA-6809371 | Formation of the cornified envelope | 3.919823e-01 | 0.407 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.930597e-01 | 0.406 |
| R-HSA-2160916 | Hyaluronan degradation | 3.975744e-01 | 0.401 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.975744e-01 | 0.401 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.975744e-01 | 0.401 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 3.975744e-01 | 0.401 |
| R-HSA-525793 | Myogenesis | 4.073525e-01 | 0.390 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 4.073525e-01 | 0.390 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 4.073525e-01 | 0.390 |
| R-HSA-3295583 | TRP channels | 4.073525e-01 | 0.390 |
| R-HSA-70635 | Urea cycle | 4.073525e-01 | 0.390 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 4.073525e-01 | 0.390 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.101218e-01 | 0.387 |
| R-HSA-6783783 | Interleukin-10 signaling | 4.101218e-01 | 0.387 |
| R-HSA-5619084 | ABC transporter disorders | 4.101218e-01 | 0.387 |
| R-HSA-9824446 | Viral Infection Pathways | 4.156831e-01 | 0.381 |
| R-HSA-74160 | Gene expression (Transcription) | 4.169380e-01 | 0.380 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.169725e-01 | 0.380 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.169725e-01 | 0.380 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.169725e-01 | 0.380 |
| R-HSA-201451 | Signaling by BMP | 4.169725e-01 | 0.380 |
| R-HSA-264876 | Insulin processing | 4.169725e-01 | 0.380 |
| R-HSA-6806834 | Signaling by MET | 4.213658e-01 | 0.375 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.213658e-01 | 0.375 |
| R-HSA-9833482 | PKR-mediated signaling | 4.213658e-01 | 0.375 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.264369e-01 | 0.370 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.264369e-01 | 0.370 |
| R-HSA-622312 | Inflammasomes | 4.264369e-01 | 0.370 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 4.264369e-01 | 0.370 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.269467e-01 | 0.370 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.351172e-01 | 0.361 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.352770e-01 | 0.361 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.357482e-01 | 0.361 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 4.357482e-01 | 0.361 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.357482e-01 | 0.361 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.357482e-01 | 0.361 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.357482e-01 | 0.361 |
| R-HSA-9018679 | Biosynthesis of EPA-derived SPMs | 4.357482e-01 | 0.361 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 4.357482e-01 | 0.361 |
| R-HSA-983712 | Ion channel transport | 4.415791e-01 | 0.355 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.449090e-01 | 0.352 |
| R-HSA-2424491 | DAP12 signaling | 4.449090e-01 | 0.352 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.449090e-01 | 0.352 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.449090e-01 | 0.352 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.487587e-01 | 0.348 |
| R-HSA-182971 | EGFR downregulation | 4.539216e-01 | 0.343 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.539216e-01 | 0.343 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.539216e-01 | 0.343 |
| R-HSA-5694530 | Cargo concentration in the ER | 4.539216e-01 | 0.343 |
| R-HSA-72766 | Translation | 4.539520e-01 | 0.343 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.544179e-01 | 0.343 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.544179e-01 | 0.343 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.565028e-01 | 0.341 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4.598219e-01 | 0.337 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.607084e-01 | 0.337 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 4.627884e-01 | 0.335 |
| R-HSA-69190 | DNA strand elongation | 4.627884e-01 | 0.335 |
| R-HSA-70268 | Pyruvate metabolism | 4.651948e-01 | 0.332 |
| R-HSA-6807070 | PTEN Regulation | 4.690777e-01 | 0.329 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.701947e-01 | 0.328 |
| R-HSA-2022854 | Keratan sulfate biosynthesis | 4.715117e-01 | 0.327 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.715117e-01 | 0.327 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.715117e-01 | 0.327 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 4.715117e-01 | 0.327 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.715117e-01 | 0.327 |
| R-HSA-354192 | Integrin signaling | 4.715117e-01 | 0.327 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 4.715117e-01 | 0.327 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.800940e-01 | 0.319 |
| R-HSA-390522 | Striated Muscle Contraction | 4.800940e-01 | 0.319 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 4.800940e-01 | 0.319 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 4.800940e-01 | 0.319 |
| R-HSA-202424 | Downstream TCR signaling | 4.811227e-01 | 0.318 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 4.863671e-01 | 0.313 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.863671e-01 | 0.313 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.885373e-01 | 0.311 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.885373e-01 | 0.311 |
| R-HSA-203615 | eNOS activation | 4.885373e-01 | 0.311 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 4.885373e-01 | 0.311 |
| R-HSA-2142845 | Hyaluronan metabolism | 4.885373e-01 | 0.311 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 4.967568e-01 | 0.304 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.968441e-01 | 0.304 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 4.968441e-01 | 0.304 |
| R-HSA-8853659 | RET signaling | 5.050165e-01 | 0.297 |
| R-HSA-163560 | Triglyceride catabolism | 5.050165e-01 | 0.297 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.050165e-01 | 0.297 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.100083e-01 | 0.292 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 5.130566e-01 | 0.290 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 5.130566e-01 | 0.290 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.130566e-01 | 0.290 |
| R-HSA-9758941 | Gastrulation | 5.140112e-01 | 0.289 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.171310e-01 | 0.286 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.179968e-01 | 0.286 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 5.209666e-01 | 0.283 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.209666e-01 | 0.283 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.219648e-01 | 0.282 |
| R-HSA-1296071 | Potassium Channels | 5.221387e-01 | 0.282 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.259151e-01 | 0.279 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.271116e-01 | 0.278 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.287487e-01 | 0.277 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.302002e-01 | 0.276 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.320495e-01 | 0.274 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.364047e-01 | 0.271 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.364047e-01 | 0.271 |
| R-HSA-167169 | HIV Transcription Elongation | 5.364047e-01 | 0.271 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.364047e-01 | 0.271 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 5.364047e-01 | 0.271 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 5.364047e-01 | 0.271 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.364047e-01 | 0.271 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.364047e-01 | 0.271 |
| R-HSA-5260271 | Diseases of Immune System | 5.364047e-01 | 0.271 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.418197e-01 | 0.266 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.418197e-01 | 0.266 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.418197e-01 | 0.266 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.439369e-01 | 0.264 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 5.439369e-01 | 0.264 |
| R-HSA-9694548 | Maturation of spike protein | 5.439369e-01 | 0.264 |
| R-HSA-9607240 | FLT3 Signaling | 5.439369e-01 | 0.264 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.439369e-01 | 0.264 |
| R-HSA-9658195 | Leishmania infection | 5.461956e-01 | 0.263 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.461956e-01 | 0.263 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.466517e-01 | 0.262 |
| R-HSA-9711097 | Cellular response to starvation | 5.492334e-01 | 0.260 |
| R-HSA-5674135 | MAP2K and MAPK activation | 5.513471e-01 | 0.259 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 5.513471e-01 | 0.259 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.513471e-01 | 0.259 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.514481e-01 | 0.258 |
| R-HSA-109582 | Hemostasis | 5.562313e-01 | 0.255 |
| R-HSA-165159 | MTOR signalling | 5.586374e-01 | 0.253 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.586374e-01 | 0.253 |
| R-HSA-9710421 | Defective pyroptosis | 5.658096e-01 | 0.247 |
| R-HSA-8854214 | TBC/RABGAPs | 5.658096e-01 | 0.247 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 5.658096e-01 | 0.247 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.658096e-01 | 0.247 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.715167e-01 | 0.243 |
| R-HSA-2172127 | DAP12 interactions | 5.728658e-01 | 0.242 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.728658e-01 | 0.242 |
| R-HSA-156581 | Methylation | 5.728658e-01 | 0.242 |
| R-HSA-5683826 | Surfactant metabolism | 5.728658e-01 | 0.242 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 5.728658e-01 | 0.242 |
| R-HSA-373752 | Netrin-1 signaling | 5.728658e-01 | 0.242 |
| R-HSA-1280218 | Adaptive Immune System | 5.773649e-01 | 0.239 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 5.798077e-01 | 0.237 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 5.798077e-01 | 0.237 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.798077e-01 | 0.237 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.798077e-01 | 0.237 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.840180e-01 | 0.234 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.866372e-01 | 0.232 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.866372e-01 | 0.232 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.866372e-01 | 0.232 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.866372e-01 | 0.232 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.866372e-01 | 0.232 |
| R-HSA-9675135 | Diseases of DNA repair | 5.866372e-01 | 0.232 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 5.866372e-01 | 0.232 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 5.866372e-01 | 0.232 |
| R-HSA-9839373 | Signaling by TGFBR3 | 5.866372e-01 | 0.232 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.885265e-01 | 0.230 |
| R-HSA-202403 | TCR signaling | 5.929987e-01 | 0.227 |
| R-HSA-437239 | Recycling pathway of L1 | 5.933561e-01 | 0.227 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.966921e-01 | 0.224 |
| R-HSA-5620924 | Intraflagellar transport | 5.999662e-01 | 0.222 |
| R-HSA-70263 | Gluconeogenesis | 5.999662e-01 | 0.222 |
| R-HSA-425410 | Metal ion SLC transporters | 5.999662e-01 | 0.222 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.009340e-01 | 0.221 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.061980e-01 | 0.217 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 6.064693e-01 | 0.217 |
| R-HSA-73893 | DNA Damage Bypass | 6.064693e-01 | 0.217 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.148164e-01 | 0.211 |
| R-HSA-157118 | Signaling by NOTCH | 6.149881e-01 | 0.211 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.190714e-01 | 0.208 |
| R-HSA-912446 | Meiotic recombination | 6.191611e-01 | 0.208 |
| R-HSA-72187 | mRNA 3'-end processing | 6.253533e-01 | 0.204 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.253533e-01 | 0.204 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.253533e-01 | 0.204 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.314452e-01 | 0.200 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.356750e-01 | 0.197 |
| R-HSA-156588 | Glucuronidation | 6.374383e-01 | 0.196 |
| R-HSA-4839726 | Chromatin organization | 6.414526e-01 | 0.193 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.433344e-01 | 0.192 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.491350e-01 | 0.188 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.491350e-01 | 0.188 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.607667e-01 | 0.180 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.617147e-01 | 0.179 |
| R-HSA-8979227 | Triglyceride metabolism | 6.659788e-01 | 0.177 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.659788e-01 | 0.177 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.714125e-01 | 0.173 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 6.714125e-01 | 0.173 |
| R-HSA-382551 | Transport of small molecules | 6.723905e-01 | 0.172 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.767581e-01 | 0.170 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.802042e-01 | 0.167 |
| R-HSA-5663205 | Infectious disease | 6.815476e-01 | 0.167 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 6.820170e-01 | 0.166 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.820170e-01 | 0.166 |
| R-HSA-9609690 | HCMV Early Events | 6.831361e-01 | 0.165 |
| R-HSA-74751 | Insulin receptor signalling cascade | 6.922805e-01 | 0.160 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.922805e-01 | 0.160 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.933178e-01 | 0.159 |
| R-HSA-9909396 | Circadian clock | 6.966923e-01 | 0.157 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 7.022140e-01 | 0.154 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.037667e-01 | 0.153 |
| R-HSA-196807 | Nicotinate metabolism | 7.070603e-01 | 0.151 |
| R-HSA-5693606 | DNA Double Strand Break Response | 7.070603e-01 | 0.151 |
| R-HSA-9830369 | Kidney development | 7.070603e-01 | 0.151 |
| R-HSA-5218859 | Regulated Necrosis | 7.118280e-01 | 0.148 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 7.118280e-01 | 0.148 |
| R-HSA-6805567 | Keratinization | 7.150897e-01 | 0.146 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 7.191782e-01 | 0.143 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.205993e-01 | 0.142 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.211328e-01 | 0.142 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.256723e-01 | 0.139 |
| R-HSA-8978934 | Metabolism of cofactors | 7.256723e-01 | 0.139 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 7.301382e-01 | 0.137 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.320341e-01 | 0.135 |
| R-HSA-1236394 | Signaling by ERBB4 | 7.388538e-01 | 0.131 |
| R-HSA-212436 | Generic Transcription Pathway | 7.411447e-01 | 0.130 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.429040e-01 | 0.129 |
| R-HSA-917937 | Iron uptake and transport | 7.431059e-01 | 0.129 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.472891e-01 | 0.127 |
| R-HSA-9694635 | Translation of Structural Proteins | 7.514043e-01 | 0.124 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.554528e-01 | 0.122 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.575007e-01 | 0.121 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 7.594356e-01 | 0.120 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 7.594356e-01 | 0.120 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.607968e-01 | 0.119 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.633538e-01 | 0.117 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.665178e-01 | 0.115 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 7.672084e-01 | 0.115 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.710005e-01 | 0.113 |
| R-HSA-73887 | Death Receptor Signaling | 7.721198e-01 | 0.112 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.784010e-01 | 0.109 |
| R-HSA-9610379 | HCMV Late Events | 7.803038e-01 | 0.108 |
| R-HSA-1500620 | Meiosis | 7.820114e-01 | 0.107 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 7.820114e-01 | 0.107 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.829742e-01 | 0.106 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 7.890574e-01 | 0.103 |
| R-HSA-913531 | Interferon Signaling | 7.906562e-01 | 0.102 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.924948e-01 | 0.101 |
| R-HSA-173623 | Classical antibody-mediated complement activation | 7.958764e-01 | 0.099 |
| R-HSA-5619102 | SLC transporter disorders | 8.057543e-01 | 0.094 |
| R-HSA-74752 | Signaling by Insulin receptor | 8.119786e-01 | 0.090 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 8.119786e-01 | 0.090 |
| R-HSA-72306 | tRNA processing | 8.151808e-01 | 0.089 |
| R-HSA-1474290 | Collagen formation | 8.180593e-01 | 0.087 |
| R-HSA-9609646 | HCMV Infection | 8.184139e-01 | 0.087 |
| R-HSA-1474244 | Extracellular matrix organization | 8.263506e-01 | 0.083 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 8.268149e-01 | 0.083 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.430595e-01 | 0.074 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.430868e-01 | 0.074 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.430868e-01 | 0.074 |
| R-HSA-1483255 | PI Metabolism | 8.430868e-01 | 0.074 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.438715e-01 | 0.074 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 8.506422e-01 | 0.070 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 8.506422e-01 | 0.070 |
| R-HSA-9833110 | RSV-host interactions | 8.506422e-01 | 0.070 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.530793e-01 | 0.069 |
| R-HSA-166786 | Creation of C4 and C2 activators | 8.554767e-01 | 0.068 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 8.601552e-01 | 0.065 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.601552e-01 | 0.065 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.618557e-01 | 0.065 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 8.624376e-01 | 0.064 |
| R-HSA-6803157 | Antimicrobial peptides | 8.668917e-01 | 0.062 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 8.690645e-01 | 0.061 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.712020e-01 | 0.060 |
| R-HSA-166663 | Initial triggering of complement | 8.753733e-01 | 0.058 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.774082e-01 | 0.057 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.794100e-01 | 0.056 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 8.794100e-01 | 0.056 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.833164e-01 | 0.054 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.833164e-01 | 0.054 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.833164e-01 | 0.054 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.907551e-01 | 0.050 |
| R-HSA-195721 | Signaling by WNT | 8.931117e-01 | 0.049 |
| R-HSA-977606 | Regulation of Complement cascade | 8.977212e-01 | 0.047 |
| R-HSA-194138 | Signaling by VEGF | 8.993925e-01 | 0.046 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.993925e-01 | 0.046 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.993925e-01 | 0.046 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.993925e-01 | 0.046 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.048824e-01 | 0.043 |
| R-HSA-1474165 | Reproduction | 9.088638e-01 | 0.042 |
| R-HSA-9843745 | Adipogenesis | 9.103536e-01 | 0.041 |
| R-HSA-5576891 | Cardiac conduction | 9.103536e-01 | 0.041 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.116208e-01 | 0.040 |
| R-HSA-163685 | Integration of energy metabolism | 9.187966e-01 | 0.037 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.254964e-01 | 0.034 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 9.288342e-01 | 0.032 |
| R-HSA-166658 | Complement cascade | 9.311441e-01 | 0.031 |
| R-HSA-2142753 | Arachidonate metabolism | 9.386562e-01 | 0.027 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 9.406484e-01 | 0.027 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.573470e-01 | 0.019 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.573470e-01 | 0.019 |
| R-HSA-112316 | Neuronal System | 9.594116e-01 | 0.018 |
| R-HSA-3781865 | Diseases of glycosylation | 9.644404e-01 | 0.016 |
| R-HSA-1483257 | Phospholipid metabolism | 9.653869e-01 | 0.015 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.655976e-01 | 0.015 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.740351e-01 | 0.011 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.779990e-01 | 0.010 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.819158e-01 | 0.008 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.836760e-01 | 0.007 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.854661e-01 | 0.006 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.869997e-01 | 0.006 |
| R-HSA-416476 | G alpha (q) signalling events | 9.907189e-01 | 0.004 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.917101e-01 | 0.004 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.926470e-01 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 9.931465e-01 | 0.003 |
| R-HSA-211859 | Biological oxidations | 9.937870e-01 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 9.948946e-01 | 0.002 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.965263e-01 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 9.967943e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.988715e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.995591e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999989e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999994e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999999e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.895 | 0.139 | 2 | 0.856 |
CLK3 |
0.891 | 0.309 | 1 | 0.885 |
PIM3 |
0.887 | 0.166 | -3 | 0.858 |
CDC7 |
0.885 | 0.057 | 1 | 0.860 |
SRPK1 |
0.884 | 0.260 | -3 | 0.794 |
CAMK1B |
0.884 | 0.156 | -3 | 0.876 |
NDR2 |
0.883 | 0.116 | -3 | 0.849 |
NLK |
0.883 | 0.164 | 1 | 0.887 |
CDKL1 |
0.882 | 0.153 | -3 | 0.832 |
PRPK |
0.881 | -0.139 | -1 | 0.855 |
RAF1 |
0.881 | -0.005 | 1 | 0.859 |
MOS |
0.880 | 0.047 | 1 | 0.885 |
PRKD1 |
0.880 | 0.142 | -3 | 0.834 |
HIPK4 |
0.879 | 0.195 | 1 | 0.869 |
RSK2 |
0.879 | 0.179 | -3 | 0.806 |
PKN3 |
0.878 | 0.107 | -3 | 0.840 |
SKMLCK |
0.878 | 0.183 | -2 | 0.914 |
CAMLCK |
0.878 | 0.185 | -2 | 0.916 |
PRKD2 |
0.877 | 0.173 | -3 | 0.794 |
IKKB |
0.877 | -0.081 | -2 | 0.789 |
PIM1 |
0.877 | 0.190 | -3 | 0.813 |
NDR1 |
0.876 | 0.100 | -3 | 0.847 |
MTOR |
0.876 | -0.096 | 1 | 0.820 |
CDKL5 |
0.875 | 0.134 | -3 | 0.824 |
SRPK2 |
0.875 | 0.230 | -3 | 0.721 |
AMPKA1 |
0.875 | 0.132 | -3 | 0.859 |
ERK5 |
0.875 | 0.083 | 1 | 0.839 |
TBK1 |
0.875 | -0.083 | 1 | 0.749 |
CAMK2G |
0.875 | -0.040 | 2 | 0.813 |
NUAK2 |
0.874 | 0.097 | -3 | 0.857 |
GCN2 |
0.874 | -0.190 | 2 | 0.804 |
ATR |
0.874 | -0.017 | 1 | 0.834 |
LATS2 |
0.874 | 0.120 | -5 | 0.861 |
BMPR2 |
0.874 | -0.160 | -2 | 0.890 |
ULK2 |
0.874 | -0.134 | 2 | 0.796 |
TSSK2 |
0.874 | 0.138 | -5 | 0.866 |
WNK1 |
0.874 | 0.052 | -2 | 0.913 |
NIK |
0.874 | 0.062 | -3 | 0.881 |
DAPK2 |
0.873 | 0.163 | -3 | 0.873 |
P90RSK |
0.873 | 0.125 | -3 | 0.807 |
MAPKAPK3 |
0.873 | 0.111 | -3 | 0.792 |
ICK |
0.873 | 0.157 | -3 | 0.858 |
PDHK4 |
0.872 | -0.311 | 1 | 0.872 |
MAPKAPK2 |
0.872 | 0.148 | -3 | 0.762 |
TSSK1 |
0.872 | 0.142 | -3 | 0.877 |
PDHK1 |
0.872 | -0.180 | 1 | 0.855 |
PKN2 |
0.871 | 0.093 | -3 | 0.848 |
P70S6KB |
0.871 | 0.135 | -3 | 0.820 |
PKCD |
0.871 | 0.128 | 2 | 0.768 |
DSTYK |
0.871 | -0.077 | 2 | 0.850 |
MARK4 |
0.871 | 0.046 | 4 | 0.875 |
IKKE |
0.871 | -0.106 | 1 | 0.745 |
RSK3 |
0.870 | 0.126 | -3 | 0.799 |
AMPKA2 |
0.870 | 0.130 | -3 | 0.834 |
PKACG |
0.870 | 0.144 | -2 | 0.816 |
RIPK3 |
0.869 | -0.054 | 3 | 0.726 |
KIS |
0.869 | 0.143 | 1 | 0.767 |
CHAK2 |
0.869 | 0.023 | -1 | 0.852 |
MST4 |
0.869 | 0.032 | 2 | 0.822 |
CLK4 |
0.869 | 0.256 | -3 | 0.799 |
CLK1 |
0.869 | 0.268 | -3 | 0.778 |
AURC |
0.869 | 0.204 | -2 | 0.753 |
IKKA |
0.868 | 0.001 | -2 | 0.764 |
LATS1 |
0.868 | 0.199 | -3 | 0.860 |
GRK6 |
0.868 | 0.036 | 1 | 0.854 |
HUNK |
0.868 | -0.082 | 2 | 0.809 |
DYRK2 |
0.868 | 0.205 | 1 | 0.786 |
SRPK3 |
0.867 | 0.190 | -3 | 0.765 |
FAM20C |
0.867 | 0.135 | 2 | 0.626 |
GRK5 |
0.866 | -0.135 | -3 | 0.848 |
WNK3 |
0.866 | -0.130 | 1 | 0.830 |
TGFBR2 |
0.866 | -0.071 | -2 | 0.781 |
NEK6 |
0.866 | -0.080 | -2 | 0.863 |
CAMK2D |
0.866 | 0.002 | -3 | 0.841 |
PAK1 |
0.866 | 0.135 | -2 | 0.869 |
NEK7 |
0.865 | -0.161 | -3 | 0.817 |
PAK3 |
0.865 | 0.102 | -2 | 0.873 |
GRK1 |
0.865 | 0.043 | -2 | 0.778 |
PKACB |
0.864 | 0.225 | -2 | 0.771 |
NIM1 |
0.864 | -0.016 | 3 | 0.787 |
CDK8 |
0.864 | 0.113 | 1 | 0.739 |
MELK |
0.864 | 0.091 | -3 | 0.818 |
PRKD3 |
0.864 | 0.117 | -3 | 0.773 |
CAMK4 |
0.864 | 0.041 | -3 | 0.826 |
MLK1 |
0.864 | -0.148 | 2 | 0.792 |
BCKDK |
0.864 | -0.132 | -1 | 0.841 |
CLK2 |
0.863 | 0.303 | -3 | 0.793 |
ULK1 |
0.863 | -0.175 | -3 | 0.793 |
MSK2 |
0.863 | 0.122 | -3 | 0.770 |
NUAK1 |
0.863 | 0.070 | -3 | 0.810 |
RSK4 |
0.863 | 0.172 | -3 | 0.778 |
MYLK4 |
0.863 | 0.167 | -2 | 0.858 |
MNK2 |
0.862 | 0.114 | -2 | 0.873 |
AURB |
0.862 | 0.185 | -2 | 0.754 |
MSK1 |
0.862 | 0.179 | -3 | 0.777 |
RIPK1 |
0.862 | -0.109 | 1 | 0.845 |
DLK |
0.862 | -0.116 | 1 | 0.850 |
QSK |
0.862 | 0.094 | 4 | 0.853 |
BMPR1B |
0.861 | 0.136 | 1 | 0.827 |
CAMK2B |
0.861 | 0.074 | 2 | 0.780 |
IRE1 |
0.861 | -0.024 | 1 | 0.827 |
PKG2 |
0.860 | 0.177 | -2 | 0.764 |
PAK6 |
0.860 | 0.159 | -2 | 0.817 |
ANKRD3 |
0.860 | -0.115 | 1 | 0.870 |
PKR |
0.860 | 0.045 | 1 | 0.870 |
NEK9 |
0.859 | -0.162 | 2 | 0.825 |
PRKX |
0.859 | 0.235 | -3 | 0.715 |
ATM |
0.859 | -0.025 | 1 | 0.768 |
CDK7 |
0.859 | 0.102 | 1 | 0.749 |
AKT2 |
0.859 | 0.187 | -3 | 0.730 |
PLK1 |
0.859 | -0.009 | -2 | 0.814 |
CDK19 |
0.859 | 0.116 | 1 | 0.702 |
HIPK1 |
0.858 | 0.219 | 1 | 0.801 |
CAMK2A |
0.858 | 0.071 | 2 | 0.785 |
HIPK2 |
0.858 | 0.222 | 1 | 0.707 |
CDK5 |
0.858 | 0.166 | 1 | 0.762 |
PIM2 |
0.858 | 0.160 | -3 | 0.778 |
CDK13 |
0.858 | 0.134 | 1 | 0.724 |
DYRK1A |
0.858 | 0.195 | 1 | 0.812 |
ALK4 |
0.857 | -0.004 | -2 | 0.820 |
MASTL |
0.857 | -0.324 | -2 | 0.839 |
JNK2 |
0.857 | 0.186 | 1 | 0.701 |
SIK |
0.857 | 0.077 | -3 | 0.779 |
TGFBR1 |
0.857 | 0.040 | -2 | 0.786 |
PAK2 |
0.857 | 0.089 | -2 | 0.856 |
SGK3 |
0.857 | 0.159 | -3 | 0.784 |
IRE2 |
0.856 | 0.004 | 2 | 0.757 |
CHK1 |
0.856 | 0.038 | -3 | 0.826 |
CDK1 |
0.856 | 0.163 | 1 | 0.714 |
QIK |
0.856 | -0.037 | -3 | 0.832 |
MLK2 |
0.856 | -0.173 | 2 | 0.808 |
JNK3 |
0.855 | 0.161 | 1 | 0.730 |
BRSK1 |
0.855 | 0.044 | -3 | 0.808 |
PKCB |
0.855 | 0.047 | 2 | 0.707 |
AURA |
0.855 | 0.174 | -2 | 0.726 |
GRK4 |
0.854 | -0.168 | -2 | 0.809 |
MARK2 |
0.854 | 0.054 | 4 | 0.786 |
VRK2 |
0.854 | -0.118 | 1 | 0.893 |
MARK3 |
0.854 | 0.068 | 4 | 0.817 |
PKCA |
0.854 | 0.041 | 2 | 0.704 |
MEK1 |
0.854 | -0.133 | 2 | 0.843 |
MNK1 |
0.854 | 0.087 | -2 | 0.874 |
P38A |
0.853 | 0.129 | 1 | 0.774 |
CAMK1G |
0.853 | 0.086 | -3 | 0.788 |
CDK2 |
0.853 | 0.116 | 1 | 0.782 |
PKCG |
0.853 | 0.008 | 2 | 0.712 |
MLK3 |
0.852 | -0.083 | 2 | 0.716 |
PKACA |
0.852 | 0.205 | -2 | 0.723 |
GRK7 |
0.852 | 0.041 | 1 | 0.783 |
PKCH |
0.851 | 0.022 | 2 | 0.705 |
P38B |
0.851 | 0.149 | 1 | 0.705 |
PKCZ |
0.851 | 0.015 | 2 | 0.766 |
HIPK3 |
0.851 | 0.181 | 1 | 0.795 |
CHAK1 |
0.851 | -0.077 | 2 | 0.784 |
NEK2 |
0.851 | -0.083 | 2 | 0.805 |
AKT1 |
0.851 | 0.199 | -3 | 0.742 |
SSTK |
0.850 | 0.100 | 4 | 0.845 |
ALK2 |
0.850 | 0.029 | -2 | 0.793 |
CDK18 |
0.850 | 0.126 | 1 | 0.681 |
DYRK3 |
0.850 | 0.224 | 1 | 0.806 |
ACVR2B |
0.850 | 0.019 | -2 | 0.787 |
CDK12 |
0.850 | 0.129 | 1 | 0.701 |
DCAMKL1 |
0.850 | 0.067 | -3 | 0.806 |
PHKG1 |
0.850 | -0.052 | -3 | 0.834 |
CDK9 |
0.850 | 0.099 | 1 | 0.731 |
P38G |
0.850 | 0.151 | 1 | 0.628 |
BRSK2 |
0.849 | -0.039 | -3 | 0.819 |
ACVR2A |
0.849 | -0.003 | -2 | 0.774 |
SMMLCK |
0.849 | 0.133 | -3 | 0.836 |
DYRK1B |
0.849 | 0.183 | 1 | 0.737 |
YSK4 |
0.849 | -0.147 | 1 | 0.789 |
SNRK |
0.849 | -0.093 | 2 | 0.712 |
ERK2 |
0.849 | 0.101 | 1 | 0.748 |
ERK1 |
0.849 | 0.121 | 1 | 0.700 |
SMG1 |
0.849 | -0.079 | 1 | 0.779 |
TTBK2 |
0.849 | -0.264 | 2 | 0.711 |
PRP4 |
0.848 | 0.089 | -3 | 0.754 |
DYRK4 |
0.848 | 0.182 | 1 | 0.711 |
BRAF |
0.848 | -0.015 | -4 | 0.824 |
PLK3 |
0.848 | -0.064 | 2 | 0.771 |
MARK1 |
0.848 | 0.020 | 4 | 0.839 |
MLK4 |
0.847 | -0.102 | 2 | 0.706 |
P70S6K |
0.847 | 0.093 | -3 | 0.737 |
PINK1 |
0.846 | -0.067 | 1 | 0.872 |
CAMK1D |
0.846 | 0.129 | -3 | 0.712 |
MAPKAPK5 |
0.846 | -0.041 | -3 | 0.739 |
DNAPK |
0.846 | -0.025 | 1 | 0.706 |
CDK3 |
0.846 | 0.178 | 1 | 0.648 |
TLK2 |
0.845 | -0.115 | 1 | 0.811 |
CDK17 |
0.845 | 0.114 | 1 | 0.631 |
BMPR1A |
0.845 | 0.096 | 1 | 0.804 |
WNK4 |
0.844 | -0.077 | -2 | 0.901 |
DCAMKL2 |
0.843 | 0.020 | -3 | 0.827 |
P38D |
0.843 | 0.168 | 1 | 0.637 |
IRAK4 |
0.843 | -0.060 | 1 | 0.829 |
CDK14 |
0.843 | 0.134 | 1 | 0.725 |
GRK2 |
0.842 | -0.059 | -2 | 0.708 |
PLK4 |
0.842 | -0.131 | 2 | 0.675 |
PASK |
0.841 | 0.051 | -3 | 0.863 |
PHKG2 |
0.841 | 0.001 | -3 | 0.814 |
HRI |
0.841 | -0.191 | -2 | 0.850 |
DAPK3 |
0.841 | 0.172 | -3 | 0.822 |
PKCT |
0.841 | 0.032 | 2 | 0.715 |
PERK |
0.840 | -0.197 | -2 | 0.822 |
MEK5 |
0.840 | -0.270 | 2 | 0.821 |
CDK10 |
0.840 | 0.164 | 1 | 0.714 |
DRAK1 |
0.840 | -0.088 | 1 | 0.796 |
AKT3 |
0.840 | 0.194 | -3 | 0.673 |
PAK5 |
0.839 | 0.106 | -2 | 0.753 |
MEKK1 |
0.838 | -0.195 | 1 | 0.822 |
MPSK1 |
0.838 | 0.005 | 1 | 0.809 |
NEK5 |
0.838 | -0.132 | 1 | 0.841 |
ZAK |
0.838 | -0.178 | 1 | 0.797 |
MEKK2 |
0.838 | -0.154 | 2 | 0.799 |
TLK1 |
0.837 | -0.136 | -2 | 0.817 |
CAMK1A |
0.837 | 0.143 | -3 | 0.696 |
MST3 |
0.837 | -0.055 | 2 | 0.800 |
SGK1 |
0.837 | 0.178 | -3 | 0.657 |
MEKK3 |
0.837 | -0.224 | 1 | 0.824 |
PKCI |
0.836 | 0.033 | 2 | 0.730 |
CDK16 |
0.836 | 0.123 | 1 | 0.646 |
TAO3 |
0.836 | -0.055 | 1 | 0.817 |
PAK4 |
0.835 | 0.106 | -2 | 0.756 |
GAK |
0.835 | 0.003 | 1 | 0.845 |
CAMKK1 |
0.835 | -0.113 | -2 | 0.807 |
CHK2 |
0.835 | 0.109 | -3 | 0.678 |
MAK |
0.834 | 0.198 | -2 | 0.760 |
MRCKA |
0.834 | 0.160 | -3 | 0.776 |
DAPK1 |
0.834 | 0.154 | -3 | 0.807 |
CK1E |
0.833 | -0.062 | -3 | 0.552 |
PKCE |
0.833 | 0.081 | 2 | 0.697 |
MRCKB |
0.833 | 0.157 | -3 | 0.765 |
ERK7 |
0.832 | 0.038 | 2 | 0.523 |
CDK6 |
0.832 | 0.148 | 1 | 0.703 |
CDK4 |
0.832 | 0.149 | 1 | 0.687 |
GSK3B |
0.832 | -0.033 | 4 | 0.432 |
PDK1 |
0.831 | -0.053 | 1 | 0.823 |
PKN1 |
0.831 | 0.061 | -3 | 0.751 |
NEK8 |
0.831 | -0.153 | 2 | 0.807 |
TAO2 |
0.831 | -0.092 | 2 | 0.830 |
SBK |
0.831 | 0.141 | -3 | 0.622 |
IRAK1 |
0.831 | -0.248 | -1 | 0.761 |
GSK3A |
0.831 | 0.014 | 4 | 0.443 |
ROCK2 |
0.831 | 0.159 | -3 | 0.805 |
CK2A2 |
0.831 | 0.088 | 1 | 0.719 |
LKB1 |
0.830 | -0.081 | -3 | 0.802 |
CAMKK2 |
0.830 | -0.112 | -2 | 0.805 |
MOK |
0.830 | 0.174 | 1 | 0.809 |
JNK1 |
0.830 | 0.103 | 1 | 0.683 |
HGK |
0.829 | -0.001 | 3 | 0.895 |
TNIK |
0.829 | 0.041 | 3 | 0.894 |
GCK |
0.829 | -0.012 | 1 | 0.828 |
MINK |
0.828 | -0.014 | 1 | 0.816 |
EEF2K |
0.828 | 0.003 | 3 | 0.884 |
MST2 |
0.827 | -0.081 | 1 | 0.822 |
NEK4 |
0.827 | -0.127 | 1 | 0.813 |
TAK1 |
0.827 | -0.074 | 1 | 0.842 |
DMPK1 |
0.827 | 0.196 | -3 | 0.791 |
NEK11 |
0.826 | -0.243 | 1 | 0.817 |
BUB1 |
0.826 | 0.102 | -5 | 0.805 |
CK1D |
0.826 | -0.055 | -3 | 0.501 |
LRRK2 |
0.825 | -0.111 | 2 | 0.840 |
GRK3 |
0.825 | -0.080 | -2 | 0.656 |
LOK |
0.825 | -0.041 | -2 | 0.821 |
HPK1 |
0.824 | -0.018 | 1 | 0.818 |
CK1A2 |
0.824 | -0.056 | -3 | 0.503 |
VRK1 |
0.823 | -0.123 | 2 | 0.834 |
KHS1 |
0.823 | 0.043 | 1 | 0.806 |
PKG1 |
0.823 | 0.121 | -2 | 0.695 |
TTBK1 |
0.823 | -0.250 | 2 | 0.638 |
MEKK6 |
0.822 | -0.153 | 1 | 0.804 |
NEK1 |
0.822 | -0.096 | 1 | 0.820 |
KHS2 |
0.822 | 0.076 | 1 | 0.823 |
MAP3K15 |
0.822 | -0.156 | 1 | 0.780 |
PLK2 |
0.822 | -0.032 | -3 | 0.781 |
CK1G1 |
0.821 | -0.118 | -3 | 0.553 |
CK2A1 |
0.820 | 0.056 | 1 | 0.700 |
MST1 |
0.820 | -0.106 | 1 | 0.808 |
ROCK1 |
0.819 | 0.154 | -3 | 0.776 |
STK33 |
0.818 | -0.151 | 2 | 0.632 |
SLK |
0.818 | -0.079 | -2 | 0.748 |
CRIK |
0.818 | 0.137 | -3 | 0.742 |
PDHK3_TYR |
0.816 | 0.201 | 4 | 0.915 |
RIPK2 |
0.816 | -0.254 | 1 | 0.756 |
YSK1 |
0.815 | -0.115 | 2 | 0.788 |
PBK |
0.815 | -0.041 | 1 | 0.752 |
MEK2 |
0.813 | -0.282 | 2 | 0.822 |
TTK |
0.810 | -0.055 | -2 | 0.808 |
OSR1 |
0.809 | -0.058 | 2 | 0.795 |
HASPIN |
0.809 | -0.003 | -1 | 0.654 |
NEK3 |
0.808 | -0.195 | 1 | 0.776 |
TESK1_TYR |
0.807 | -0.029 | 3 | 0.892 |
MYO3B |
0.807 | -0.015 | 2 | 0.810 |
PDHK4_TYR |
0.805 | 0.023 | 2 | 0.864 |
BIKE |
0.805 | -0.016 | 1 | 0.711 |
MYO3A |
0.803 | -0.053 | 1 | 0.820 |
LIMK2_TYR |
0.803 | 0.048 | -3 | 0.879 |
MAP2K4_TYR |
0.803 | -0.092 | -1 | 0.877 |
BMPR2_TYR |
0.803 | 0.025 | -1 | 0.880 |
MAP2K6_TYR |
0.803 | -0.038 | -1 | 0.884 |
PKMYT1_TYR |
0.802 | -0.108 | 3 | 0.845 |
MAP2K7_TYR |
0.801 | -0.229 | 2 | 0.856 |
EPHA6 |
0.801 | 0.083 | -1 | 0.896 |
ASK1 |
0.800 | -0.196 | 1 | 0.766 |
PINK1_TYR |
0.799 | -0.154 | 1 | 0.858 |
PDHK1_TYR |
0.799 | -0.078 | -1 | 0.894 |
ALPHAK3 |
0.798 | -0.090 | -1 | 0.778 |
TAO1 |
0.797 | -0.134 | 1 | 0.746 |
RET |
0.795 | -0.102 | 1 | 0.816 |
EPHB4 |
0.795 | 0.007 | -1 | 0.882 |
YANK3 |
0.794 | -0.103 | 2 | 0.411 |
TYRO3 |
0.793 | -0.102 | 3 | 0.807 |
LIMK1_TYR |
0.793 | -0.184 | 2 | 0.854 |
TYK2 |
0.792 | -0.161 | 1 | 0.810 |
ROS1 |
0.792 | -0.093 | 3 | 0.769 |
DDR1 |
0.792 | -0.104 | 4 | 0.837 |
MST1R |
0.790 | -0.161 | 3 | 0.799 |
STLK3 |
0.790 | -0.209 | 1 | 0.764 |
CSF1R |
0.790 | -0.107 | 3 | 0.781 |
TXK |
0.789 | 0.061 | 1 | 0.836 |
JAK2 |
0.789 | -0.165 | 1 | 0.808 |
ABL2 |
0.789 | -0.044 | -1 | 0.829 |
AAK1 |
0.787 | 0.020 | 1 | 0.606 |
INSRR |
0.787 | -0.060 | 3 | 0.741 |
YES1 |
0.787 | -0.079 | -1 | 0.860 |
JAK3 |
0.786 | -0.113 | 1 | 0.793 |
EPHA4 |
0.785 | -0.038 | 2 | 0.762 |
TNNI3K_TYR |
0.785 | -0.007 | 1 | 0.830 |
FER |
0.785 | -0.147 | 1 | 0.855 |
EPHB1 |
0.784 | -0.051 | 1 | 0.839 |
ABL1 |
0.784 | -0.076 | -1 | 0.822 |
PDGFRB |
0.784 | -0.141 | 3 | 0.807 |
CK1A |
0.783 | -0.107 | -3 | 0.415 |
ITK |
0.783 | -0.066 | -1 | 0.821 |
TNK2 |
0.783 | -0.097 | 3 | 0.736 |
EPHB3 |
0.783 | -0.052 | -1 | 0.873 |
FGR |
0.782 | -0.182 | 1 | 0.839 |
HCK |
0.782 | -0.104 | -1 | 0.848 |
EPHB2 |
0.781 | -0.032 | -1 | 0.865 |
NEK10_TYR |
0.781 | -0.102 | 1 | 0.703 |
FGFR2 |
0.781 | -0.157 | 3 | 0.781 |
TNK1 |
0.781 | -0.103 | 3 | 0.776 |
SRMS |
0.781 | -0.105 | 1 | 0.846 |
FLT3 |
0.781 | -0.141 | 3 | 0.803 |
LCK |
0.781 | -0.041 | -1 | 0.847 |
AXL |
0.780 | -0.123 | 3 | 0.762 |
KIT |
0.779 | -0.172 | 3 | 0.789 |
TEK |
0.779 | -0.170 | 3 | 0.735 |
MERTK |
0.778 | -0.091 | 3 | 0.753 |
BLK |
0.778 | -0.020 | -1 | 0.856 |
FGFR1 |
0.778 | -0.167 | 3 | 0.756 |
KDR |
0.778 | -0.145 | 3 | 0.741 |
TEC |
0.777 | -0.073 | -1 | 0.766 |
JAK1 |
0.776 | -0.122 | 1 | 0.754 |
PDGFRA |
0.776 | -0.222 | 3 | 0.804 |
BMX |
0.775 | -0.077 | -1 | 0.741 |
WEE1_TYR |
0.775 | -0.087 | -1 | 0.746 |
ALK |
0.775 | -0.139 | 3 | 0.711 |
EPHA7 |
0.774 | -0.068 | 2 | 0.772 |
DDR2 |
0.774 | -0.007 | 3 | 0.722 |
BTK |
0.773 | -0.208 | -1 | 0.787 |
MET |
0.773 | -0.173 | 3 | 0.771 |
LTK |
0.772 | -0.150 | 3 | 0.721 |
EPHA3 |
0.771 | -0.136 | 2 | 0.743 |
PTK6 |
0.770 | -0.241 | -1 | 0.741 |
EPHA1 |
0.770 | -0.141 | 3 | 0.749 |
FRK |
0.770 | -0.122 | -1 | 0.857 |
FYN |
0.769 | -0.058 | -1 | 0.821 |
INSR |
0.769 | -0.166 | 3 | 0.714 |
NTRK1 |
0.769 | -0.233 | -1 | 0.846 |
FGFR3 |
0.769 | -0.187 | 3 | 0.752 |
PTK2B |
0.768 | -0.067 | -1 | 0.802 |
NTRK2 |
0.768 | -0.226 | 3 | 0.744 |
FLT1 |
0.767 | -0.176 | -1 | 0.856 |
EPHA5 |
0.767 | -0.069 | 2 | 0.751 |
ERBB2 |
0.766 | -0.244 | 1 | 0.761 |
FLT4 |
0.765 | -0.226 | 3 | 0.727 |
CK1G3 |
0.765 | -0.111 | -3 | 0.371 |
LYN |
0.765 | -0.153 | 3 | 0.709 |
PTK2 |
0.762 | 0.015 | -1 | 0.831 |
NTRK3 |
0.762 | -0.200 | -1 | 0.796 |
EPHA8 |
0.762 | -0.118 | -1 | 0.845 |
MATK |
0.762 | -0.183 | -1 | 0.747 |
EGFR |
0.759 | -0.138 | 1 | 0.667 |
SRC |
0.758 | -0.151 | -1 | 0.821 |
CSK |
0.758 | -0.210 | 2 | 0.777 |
YANK2 |
0.755 | -0.162 | 2 | 0.426 |
FGFR4 |
0.755 | -0.173 | -1 | 0.790 |
SYK |
0.754 | -0.053 | -1 | 0.799 |
IGF1R |
0.754 | -0.161 | 3 | 0.656 |
EPHA2 |
0.753 | -0.113 | -1 | 0.816 |
MUSK |
0.750 | -0.208 | 1 | 0.650 |
ERBB4 |
0.746 | -0.129 | 1 | 0.688 |
FES |
0.737 | -0.196 | -1 | 0.718 |
CK1G2 |
0.736 | -0.156 | -3 | 0.466 |
ZAP70 |
0.726 | -0.144 | -1 | 0.717 |