Motif 716 (n=133)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| K7ELQ4 | ATF7-NPFF | S100 | ochoa | ATF7-NPFF readthrough | None |
| O00567 | NOP56 | S556 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O00571 | DDX3X | S152 | ochoa|psp | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O15031 | PLXNB2 | S1244 | ochoa | Plexin-B2 (MM1) | Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus (PubMed:29100074, PubMed:32510170). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458). Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888). May modulate the activity of RAC1 and CDC42 (By similarity). {ECO:0000250|UniProtKB:B2RXS4, ECO:0000269|PubMed:12183458, ECO:0000269|PubMed:15184888, ECO:0000269|PubMed:29100074, ECO:0000269|PubMed:32510170}. |
| O15523 | DDX3Y | S150 | ochoa | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}. |
| O43934 | MFSD11 | S204 | ochoa | UNC93-like protein MFSD11 (Major facilitator superfamily domain-containing protein 11) (Protein ET) | None |
| O75643 | SNRNP200 | S26 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O95164 | UBL3 | S31 | ochoa | Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1) | None |
| O95405 | ZFYVE9 | S121 | ochoa | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:9865696}. |
| O95810 | CAVIN2 | S203 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P02549 | SPTA1 | S421 | ochoa | Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P05165 | PCCA | S251 | ochoa | Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha) | This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:6765947, PubMed:8434582). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:10101253, PubMed:6765947, PubMed:8434582). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:6765947). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). {ECO:0000250|UniProtKB:P0DTA4, ECO:0000250|UniProtKB:Q5LUF3, ECO:0000269|PubMed:10101253, ECO:0000269|PubMed:6765947, ECO:0000269|PubMed:8434582}. |
| P06239 | LCK | S158 | ochoa|psp | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P08567 | PLEK | S230 | ochoa | Pleckstrin (Platelet 47 kDa protein) (p47) | Major protein kinase C substrate of platelets. |
| P11055 | MYH3 | S1336 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11055 | MYH3 | S1337 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11171 | EPB41 | S151 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P11171 | EPB41 | Y660 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12277 | CKB | S163 | ochoa | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| P12882 | MYH1 | S1339 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1340 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1611 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1335 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1337 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1338 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13535 | MYH8 | S1339 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P20810 | CAST | S297 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P26358 | DNMT1 | S387 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P29374 | ARID4A | S276 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P32298 | GRK4 | S485 | psp | G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}. |
| P34947 | GRK5 | S484 | ochoa|psp | G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) | Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). {ECO:0000269|PubMed:19661922, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20038610, ECO:0000269|PubMed:20124405, ECO:0000269|PubMed:21728385}. |
| P35659 | DEK | S232 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P35749 | MYH11 | S1161 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P43243 | MATR3 | S118 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P43250 | GRK6 | S484 | ochoa|psp | G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}. |
| P51003 | PAPOLA | S717 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P51114 | FXR1 | S587 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P61278 | SST | S74 | ochoa | Somatostatin (Growth hormone release-inhibiting factor) [Cleaved into: Somatostatin-28; Somatostatin-14 (SST-14); Neuronostatin (NST)] | [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. {ECO:0000269|PubMed:29615476}.; FUNCTION: [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity). This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476). {ECO:0000250|UniProtKB:P60041, ECO:0000250|UniProtKB:P60042, ECO:0000269|PubMed:29615476}. |
| P62993 | GRB2 | S90 | ochoa | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11726515, PubMed:37626338). Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis (PubMed:35831301, PubMed:37626338, PubMed:38182563). Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells (PubMed:36864087, PubMed:9489702). Mechanistically, engagement of the TCR leads to phosphorylation of the adapter protein LAT, which serves as docking site for GRB2 (PubMed:9489702). In turn, GRB2 establishes a a connection with SOS1 that acts as a guanine nucleotide exchange factor and serves as a critical regulator of KRAS/RAF1 leading to MAPKs translocation to the nucleus and activation (PubMed:12171928, PubMed:25870599). Functions also a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) (PubMed:25413232, PubMed:29523808). Plays a role in switching between autophagy and programmed necrosis upstream of EGFR by interacting with components of necrosomes including RIPK1 and with autophagy regulators SQSTM1 and BECN1 (PubMed:35831301, PubMed:38182563). Regulates miRNA biogenesis by forming a functional ternary complex with AGO2 and DICER1 (PubMed:37328606). Functions in the replication stress response by protecting DNA at stalled replication forks from MRE11-mediated degradation. Mechanistically, inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks (PubMed:38459011). Additionally, directly recruits and later releases MRE11 at DNA damage sites during the homology-directed repair (HDR) process (PubMed:34348893). {ECO:0000269|PubMed:11726515, ECO:0000269|PubMed:12171928, ECO:0000269|PubMed:1322798, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:25413232, ECO:0000269|PubMed:25870599, ECO:0000269|PubMed:29523808, ECO:0000269|PubMed:34348893, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:36864087, ECO:0000269|PubMed:37328606, ECO:0000269|PubMed:37626338, ECO:0000269|PubMed:38182563, ECO:0000269|PubMed:38459011, ECO:0000269|PubMed:9489702}.; FUNCTION: [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Mechanistically, inhibits RAS-ERK signaling and downstream cell proliferation by competing with GRB2 for SOS1 binding and thus by regulating SOS1 membrane recruitment (PubMed:36171279). {ECO:0000269|PubMed:36171279, ECO:0000269|PubMed:8178156}. |
| P78559 | MAP1A | S1029 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P82094 | TMF1 | S23 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| P82094 | TMF1 | S541 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| P82987 | ADAMTSL3 | S631 | ochoa | ADAMTS-like protein 3 (ADAMTSL-3) (Punctin-2) | None |
| Q01082 | SPTBN1 | S257 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q02952 | AKAP12 | S792 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q07666 | KHDRBS1 | S113 | ochoa | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q12912 | IRAG2 | S93 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| Q13118 | KLF10 | S184 | ochoa | Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}. |
| Q13247 | SRSF6 | S45 | ochoa | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}. |
| Q13796 | SHROOM2 | S1425 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14C86 | GAPVD1 | S1012 | psp | GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) | Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269|PubMed:16410077}. |
| Q15025 | TNIP1 | S79 | ochoa | TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) | Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814, ECO:0000269|PubMed:21885437}. |
| Q15424 | SAFB | S195 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q1ED39 | KNOP1 | S127 | ochoa | Lysine-rich nucleolar protein 1 (Protein FAM191A) (Testis-specific gene 118 protein) | None |
| Q3L8U1 | CHD9 | S2058 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q4V328 | GRIPAP1 | S241 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q53T59 | HS1BP3 | S258 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5JTV8 | TOR1AIP1 | S79 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5TB80 | CEP162 | S144 | ochoa | Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) | Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. {ECO:0000269|PubMed:23644468}. |
| Q5UIP0 | RIF1 | S1046 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VZK9 | CARMIL1 | S967 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q68E01 | INTS3 | S578 | ochoa | Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS3 is involved in the post-termination step: INTS3 binds INTS7 in the open conformation of integrator complex and prevents the rebinding of Pol II to the integrator after termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}.; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. |
| Q6GYQ0 | RALGAPA1 | S349 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6P0N0 | MIS18BP1 | S1008 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P3S1 | DENND1B | S514 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
| Q6VMQ6 | ATF7IP | S310 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6VN20 | RANBP10 | S490 | ochoa | Ran-binding protein 10 (RanBP10) | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250|UniProtKB:Q6VN19, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q6ZU65 | UBN2 | S633 | ochoa | Ubinuclein-2 | None |
| Q7Z3K6 | MIER3 | S122 | ochoa | Mesoderm induction early response protein 3 (Mi-er3) | Transcriptional repressor. {ECO:0000250}. |
| Q7Z406 | MYH14 | S1329 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q7Z6E9 | RBBP6 | S979 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86TI0 | TBC1D1 | S570 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86VM9 | ZC3H18 | S78 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q8IX21 | SLF2 | S710 | ochoa | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
| Q8IYB3 | SRRM1 | S240 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZE3 | SCYL3 | S569 | ochoa | Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3) | May play a role in regulating cell adhesion/migration complexes in migrating cells. {ECO:0000269|PubMed:12651155}. |
| Q8N108 | MIER1 | S130 | ochoa | Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) | Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}. |
| Q8N4C6 | NIN | S1550 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N5C6 | SRBD1 | S151 | ochoa | S1 RNA-binding domain-containing protein 1 | None |
| Q8NBJ4 | GOLM1 | S87 | ochoa | Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) | Unknown. Cellular response protein to viral infection. |
| Q8NEM2 | SHCBP1 | S42 | ochoa | SHC SH2 domain-binding protein 1 | May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000250|UniProtKB:Q9Z179}. |
| Q8NEY1 | NAV1 | S391 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFC6 | BOD1L1 | S482 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8WXH0 | SYNE2 | S4025 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92878 | RAD50 | S635 | ochoa|psp | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q96DX7 | TRIM44 | S323 | ochoa | Tripartite motif-containing protein 44 (Protein DIPB) | May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807). {ECO:0000250, ECO:0000269|PubMed:19358823, ECO:0000269|PubMed:26394807}. |
| Q96EB6 | SIRT1 | S562 | ochoa | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96GN5 | CDCA7L | S237 | ochoa | Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2) | Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933, ECO:0000269|PubMed:16829576}. |
| Q96HR8 | NAF1 | S184 | ochoa | H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1) | RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}. |
| Q96IZ7 | RSRC1 | S239 | ochoa | Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) | Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. {ECO:0000269|PubMed:15798186, ECO:0000269|PubMed:29522154}. |
| Q96L93 | KIF16B | S881 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96ST8 | CEP89 | S173 | ochoa | Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) | Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}. |
| Q96T23 | RSF1 | S977 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q9BPZ7 | MAPKAP1 | S459 | ochoa | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BXW9 | FANCD2 | S891 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BZ29 | DOCK9 | S1282 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9C040 | TRIM2 | S375 | ochoa | Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) | UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}. |
| Q9C0G0 | ZNF407 | S822 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9GZR1 | SENP6 | S335 | ochoa | Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. |
| Q9H089 | LSG1 | S58 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H1E3 | NUCKS1 | S130 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H2P0 | ADNP | S874 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H4G0 | EPB41L1 | S667 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H4Z3 | PCIF1 | S121 | ochoa | mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121) | Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). {ECO:0000269|PubMed:30467178, ECO:0000269|PubMed:30487554, ECO:0000269|PubMed:31279658, ECO:0000269|PubMed:31279659, ECO:0000269|PubMed:33428944}. |
| Q9H7L9 | SUDS3 | S53 | ochoa | Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog) | Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:21239494}. |
| Q9NZN5 | ARHGEF12 | S1394 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P219 | CCDC88C | S951 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P246 | STIM2 | S261 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P2K8 | EIF2AK4 | S207 | ochoa | eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}. |
| Q9UEE5 | STK17A | S354 | ochoa | Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1) | Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. {ECO:0000269|PubMed:21489989, ECO:0000269|PubMed:9786912}. |
| Q9UGP4 | LIMD1 | S24 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UHG0 | DCDC2 | S433 | ochoa | Doublecortin domain-containing protein 2 (Protein RU2S) | Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). {ECO:0000250|UniProtKB:D3ZR10, ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}. |
| Q9UIL8 | PHF11 | S254 | ochoa | PHD finger protein 11 (BRCA1 C-terminus-associated protein) (Renal carcinoma antigen NY-REN-34) | Positive regulator of Th1-type cytokine gene expression. {ECO:0000269|PubMed:18405956}. |
| Q9UJC3 | HOOK1 | S235 | ochoa | Protein Hook homolog 1 (h-hook1) (hHK1) | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). {ECO:0000250|UniProtKB:Q8BIL5, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q9UKX2 | MYH2 | S1341 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1342 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1613 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UQ84 | EXO1 | S660 | ochoa | Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}. |
| Q9Y2B0 | CNPY2 | S99 | ochoa | Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) | Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
| Q9Y2D4 | EXOC6B | S265 | ochoa | Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q9Y2I6 | NINL | S448 | psp | Ninein-like protein | Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}. |
| Q9Y2X9 | ZNF281 | S812 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y448 | KNSTRN | S241 | ochoa | Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1) | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}. |
| Q9Y5B9 | SUPT16H | S986 | ochoa | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
| Q9Y5K6 | CD2AP | S458 | ochoa | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y678 | COPG1 | S246 | ochoa | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269|PubMed:20674546}. |
| P35579 | MYH9 | S1154 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| Q9NY33 | DPP3 | S194 | Sugiyama | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
| P08575 | PTPRC | S1004 | SIGNOR | Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. {ECO:0000250, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:16998493, ECO:0000269|PubMed:2845400, ECO:0000269|PubMed:35767951}.; FUNCTION: (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. {ECO:0000269|PubMed:22174689}. |
| Q9HBH7 | BEX1 | S102 | SIGNOR | Protein BEX1 (Brain-expressed X-linked protein 1) | Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). {ECO:0000250|UniProtKB:Q3MKQ2, ECO:0000250|UniProtKB:Q9R224}. |
| O60610 | DIAPH1 | S793 | Sugiyama | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| Q06124 | PTPN11 | S142 | Sugiyama | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884). {ECO:0000250|UniProtKB:P35235, ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:19275884, ECO:0000269|PubMed:26742426, ECO:0000269|PubMed:28074573}. |
| O60763 | USO1 | S776 | Sugiyama | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.000067 | 4.172 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.000153 | 3.816 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.000524 | 3.281 |
| R-HSA-373755 | Semaphorin interactions | 0.000372 | 3.430 |
| R-HSA-8865999 | MET activates PTPN11 | 0.000861 | 3.065 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.000861 | 3.065 |
| R-HSA-9927353 | Co-inhibition by BTLA | 0.001669 | 2.778 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.001669 | 2.778 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.002066 | 2.685 |
| R-HSA-9645135 | STAT5 Activation | 0.002728 | 2.564 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.002880 | 2.541 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.003567 | 2.448 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.003567 | 2.448 |
| R-HSA-390522 | Striated Muscle Contraction | 0.004914 | 2.309 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.005568 | 2.254 |
| R-HSA-210990 | PECAM1 interactions | 0.006423 | 2.192 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.006346 | 2.197 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.006869 | 2.163 |
| R-HSA-8851805 | MET activates RAS signaling | 0.008297 | 2.081 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.008297 | 2.081 |
| R-HSA-9607240 | FLT3 Signaling | 0.008088 | 2.092 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.007640 | 2.117 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.009315 | 2.031 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.009526 | 2.021 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.012235 | 1.912 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.010386 | 1.984 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.012235 | 1.912 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.010386 | 1.984 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.011509 | 1.939 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.013294 | 1.876 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.013907 | 1.857 |
| R-HSA-180292 | GAB1 signalosome | 0.016500 | 1.783 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.017868 | 1.748 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.017868 | 1.748 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.019283 | 1.715 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.019283 | 1.715 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.019283 | 1.715 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.019283 | 1.715 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.019283 | 1.715 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.023796 | 1.623 |
| R-HSA-72187 | mRNA 3'-end processing | 0.014688 | 1.833 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.023796 | 1.623 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.022247 | 1.653 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.023796 | 1.623 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.021157 | 1.675 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.019283 | 1.715 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.023796 | 1.623 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.021957 | 1.658 |
| R-HSA-210993 | Tie2 Signaling | 0.016500 | 1.783 |
| R-HSA-373753 | Nephrin family interactions | 0.019283 | 1.715 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.017400 | 1.759 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.028696 | 1.542 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.028696 | 1.542 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.027021 | 1.568 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.028696 | 1.542 |
| R-HSA-199991 | Membrane Trafficking | 0.026895 | 1.570 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.027073 | 1.567 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.027105 | 1.567 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.026264 | 1.581 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.029899 | 1.524 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.030412 | 1.517 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.035794 | 1.446 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.032167 | 1.493 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.035794 | 1.446 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.033961 | 1.469 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.032167 | 1.493 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.032167 | 1.493 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.033961 | 1.469 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.035794 | 1.446 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.032167 | 1.493 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.035794 | 1.446 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.049420 | 1.306 |
| R-HSA-2424491 | DAP12 signaling | 0.037664 | 1.424 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.052211 | 1.282 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.043491 | 1.362 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.045504 | 1.342 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.037664 | 1.424 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.049629 | 1.304 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.043491 | 1.362 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.049629 | 1.304 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.047550 | 1.323 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.041355 | 1.383 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.047550 | 1.323 |
| R-HSA-6806834 | Signaling by MET | 0.039156 | 1.407 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.047550 | 1.323 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.052071 | 1.283 |
| R-HSA-8853659 | RET signaling | 0.051741 | 1.286 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.047550 | 1.323 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.049629 | 1.304 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.043491 | 1.362 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.049420 | 1.306 |
| R-HSA-186763 | Downstream signal transduction | 0.039571 | 1.403 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.051741 | 1.286 |
| R-HSA-9659379 | Sensory processing of sound | 0.038064 | 1.419 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.047247 | 1.326 |
| R-HSA-422475 | Axon guidance | 0.051436 | 1.289 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.037664 | 1.424 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.054919 | 1.260 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.056059 | 1.251 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.056093 | 1.251 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.057418 | 1.241 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.057418 | 1.241 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.057418 | 1.241 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.058264 | 1.235 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.058755 | 1.231 |
| R-HSA-112412 | SOS-mediated signalling | 0.081012 | 1.091 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.088746 | 1.052 |
| R-HSA-8875656 | MET receptor recycling | 0.088746 | 1.052 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.104020 | 0.983 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.126456 | 0.898 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.133810 | 0.874 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.155506 | 0.808 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.162617 | 0.789 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.074496 | 1.128 |
| R-HSA-774815 | Nucleosome assembly | 0.074496 | 1.128 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.076921 | 1.114 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.224002 | 0.650 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.094559 | 1.024 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.243454 | 0.614 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.243454 | 0.614 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.150020 | 0.824 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.173702 | 0.760 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.217408 | 0.663 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.081012 | 1.091 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.243454 | 0.614 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.176548 | 0.753 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.119040 | 0.924 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.148335 | 0.829 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.162617 | 0.789 |
| R-HSA-74749 | Signal attenuation | 0.104020 | 0.983 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.228746 | 0.641 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.132736 | 0.877 |
| R-HSA-177929 | Signaling by EGFR | 0.102442 | 0.990 |
| R-HSA-2172127 | DAP12 interactions | 0.072096 | 1.142 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.065349 | 1.185 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.111562 | 0.952 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.119040 | 0.924 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.148335 | 0.829 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.148335 | 0.829 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.148335 | 0.829 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.162617 | 0.789 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.197292 | 0.705 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.204054 | 0.690 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.224002 | 0.650 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.243454 | 0.614 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.176662 | 0.753 |
| R-HSA-190236 | Signaling by FGFR | 0.234953 | 0.629 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.069722 | 1.157 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.169669 | 0.770 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.183596 | 0.736 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.144207 | 0.841 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.074496 | 1.128 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.190473 | 0.720 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.126456 | 0.898 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.099795 | 1.001 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.124279 | 0.906 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.170707 | 0.768 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.169669 | 0.770 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.169669 | 0.770 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.204054 | 0.690 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.102442 | 0.990 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.176662 | 0.753 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.096415 | 1.016 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.104020 | 0.983 |
| R-HSA-71032 | Propionyl-CoA catabolism | 0.111562 | 0.952 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.141103 | 0.850 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.237024 | 0.625 |
| R-HSA-112399 | IRS-mediated signalling | 0.105110 | 0.978 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.081845 | 1.087 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.224002 | 0.650 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.176705 | 0.753 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.197292 | 0.705 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.197292 | 0.705 |
| R-HSA-9842663 | Signaling by LTK | 0.126456 | 0.898 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.224002 | 0.650 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.124279 | 0.906 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.213286 | 0.671 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.067375 | 1.172 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.073213 | 1.135 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.148335 | 0.829 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.148335 | 0.829 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.110574 | 0.956 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.150020 | 0.824 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.127083 | 0.896 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.081012 | 1.091 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.081012 | 1.091 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.104020 | 0.983 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.126456 | 0.898 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.126456 | 0.898 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.115961 | 0.936 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.152943 | 0.815 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.150110 | 0.824 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.243454 | 0.614 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.188795 | 0.724 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.126456 | 0.898 |
| R-HSA-5358508 | Mismatch Repair | 0.176662 | 0.753 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.168967 | 0.772 |
| R-HSA-196780 | Biotin transport and metabolism | 0.148335 | 0.829 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.126456 | 0.898 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.169669 | 0.770 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.183596 | 0.736 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.148133 | 0.829 |
| R-HSA-9664407 | Parasite infection | 0.148133 | 0.829 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.148133 | 0.829 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.113222 | 0.946 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.118304 | 0.927 |
| R-HSA-164944 | Nef and signal transduction | 0.073213 | 1.135 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.081012 | 1.091 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.169669 | 0.770 |
| R-HSA-167044 | Signalling to RAS | 0.197292 | 0.705 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.210759 | 0.676 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.125118 | 0.903 |
| R-HSA-1500620 | Meiosis | 0.185761 | 0.731 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.205786 | 0.687 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.092983 | 1.032 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.148335 | 0.829 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.096415 | 1.016 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.133810 | 0.874 |
| R-HSA-71288 | Creatine metabolism | 0.190473 | 0.720 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.204054 | 0.690 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.210759 | 0.676 |
| R-HSA-109704 | PI3K Cascade | 0.086864 | 1.061 |
| R-HSA-397014 | Muscle contraction | 0.134281 | 0.872 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.133810 | 0.874 |
| R-HSA-9675135 | Diseases of DNA repair | 0.076921 | 1.114 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.141103 | 0.850 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.223838 | 0.650 |
| R-HSA-877300 | Interferon gamma signaling | 0.189163 | 0.723 |
| R-HSA-9707616 | Heme signaling | 0.118718 | 0.925 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.111562 | 0.952 |
| R-HSA-416700 | Other semaphorin interactions | 0.148335 | 0.829 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.176662 | 0.753 |
| R-HSA-2586552 | Signaling by Leptin | 0.104020 | 0.983 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.204054 | 0.690 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.091972 | 1.036 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.237024 | 0.625 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.217408 | 0.663 |
| R-HSA-186797 | Signaling by PDGF | 0.118718 | 0.925 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.226048 | 0.646 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.224002 | 0.650 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.224002 | 0.650 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.224002 | 0.650 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.243454 | 0.614 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.197936 | 0.703 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.210759 | 0.676 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.217408 | 0.663 |
| R-HSA-9675108 | Nervous system development | 0.070496 | 1.152 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.162617 | 0.789 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.169669 | 0.770 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.185761 | 0.731 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.237773 | 0.624 |
| R-HSA-74160 | Gene expression (Transcription) | 0.167017 | 0.777 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.217408 | 0.663 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.170333 | 0.769 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.111562 | 0.952 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.065011 | 1.187 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.135776 | 0.867 |
| R-HSA-1500931 | Cell-Cell communication | 0.156293 | 0.806 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.118651 | 0.926 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.207131 | 0.684 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.246866 | 0.608 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.249830 | 0.602 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.249830 | 0.602 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.256152 | 0.592 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.256152 | 0.592 |
| R-HSA-5334118 | DNA methylation | 0.256152 | 0.592 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.256152 | 0.592 |
| R-HSA-5617833 | Cilium Assembly | 0.259648 | 0.586 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.262422 | 0.581 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.262422 | 0.581 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.262422 | 0.581 |
| R-HSA-182971 | EGFR downregulation | 0.268639 | 0.571 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.268639 | 0.571 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.268726 | 0.571 |
| R-HSA-202403 | TCR signaling | 0.275452 | 0.560 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.276444 | 0.558 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.278313 | 0.555 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 0.280917 | 0.551 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.280917 | 0.551 |
| R-HSA-9930044 | Nuclear RNA decay | 0.280917 | 0.551 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.280917 | 0.551 |
| R-HSA-354192 | Integrin signaling | 0.280917 | 0.551 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.280917 | 0.551 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.282410 | 0.549 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.286980 | 0.542 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.287916 | 0.541 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.292991 | 0.533 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.292991 | 0.533 |
| R-HSA-72172 | mRNA Splicing | 0.293862 | 0.532 |
| R-HSA-187687 | Signalling to ERKs | 0.298953 | 0.524 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.298953 | 0.524 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.298953 | 0.524 |
| R-HSA-373760 | L1CAM interactions | 0.300357 | 0.522 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.303463 | 0.518 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.304864 | 0.516 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.304864 | 0.516 |
| R-HSA-5693538 | Homology Directed Repair | 0.306566 | 0.513 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 0.310726 | 0.508 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.310726 | 0.508 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.310726 | 0.508 |
| R-HSA-73886 | Chromosome Maintenance | 0.315859 | 0.501 |
| R-HSA-8875878 | MET promotes cell motility | 0.316539 | 0.500 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.322303 | 0.492 |
| R-HSA-201556 | Signaling by ALK | 0.322303 | 0.492 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.322303 | 0.492 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.323692 | 0.490 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.328019 | 0.484 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.328019 | 0.484 |
| R-HSA-167169 | HIV Transcription Elongation | 0.328019 | 0.484 |
| R-HSA-202433 | Generation of second messenger molecules | 0.328019 | 0.484 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.333687 | 0.477 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.333687 | 0.477 |
| R-HSA-69481 | G2/M Checkpoints | 0.337430 | 0.472 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.339308 | 0.469 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.344881 | 0.462 |
| R-HSA-1474165 | Reproduction | 0.349668 | 0.456 |
| R-HSA-9710421 | Defective pyroptosis | 0.350408 | 0.455 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.350408 | 0.455 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.355760 | 0.449 |
| R-HSA-9909396 | Circadian clock | 0.355760 | 0.449 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.355889 | 0.449 |
| R-HSA-373752 | Netrin-1 signaling | 0.355889 | 0.449 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.361323 | 0.442 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.361323 | 0.442 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.362863 | 0.440 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.365745 | 0.437 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.366712 | 0.436 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.366712 | 0.436 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.369738 | 0.432 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.372056 | 0.429 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.375307 | 0.426 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.376095 | 0.425 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.387821 | 0.411 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.392988 | 0.406 |
| R-HSA-912446 | Meiotic recombination | 0.392988 | 0.406 |
| R-HSA-2514856 | The phototransduction cascade | 0.392988 | 0.406 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.394822 | 0.404 |
| R-HSA-4839726 | Chromatin organization | 0.397096 | 0.401 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.398112 | 0.400 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.398112 | 0.400 |
| R-HSA-73894 | DNA Repair | 0.400108 | 0.398 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.403193 | 0.394 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.403193 | 0.394 |
| R-HSA-1221632 | Meiotic synapsis | 0.403193 | 0.394 |
| R-HSA-72649 | Translation initiation complex formation | 0.408232 | 0.389 |
| R-HSA-166520 | Signaling by NTRKs | 0.409567 | 0.388 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.418182 | 0.379 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.418182 | 0.379 |
| R-HSA-1640170 | Cell Cycle | 0.419438 | 0.377 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.421237 | 0.375 |
| R-HSA-162582 | Signal Transduction | 0.426225 | 0.370 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.427029 | 0.370 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.427966 | 0.369 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.432797 | 0.364 |
| R-HSA-983189 | Kinesins | 0.437587 | 0.359 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.437587 | 0.359 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.447047 | 0.350 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.447047 | 0.350 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.451718 | 0.345 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.451718 | 0.345 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.451718 | 0.345 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.451718 | 0.345 |
| R-HSA-8848021 | Signaling by PTK6 | 0.451718 | 0.345 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.451718 | 0.345 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.460942 | 0.336 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.460942 | 0.336 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.465497 | 0.332 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.468248 | 0.330 |
| R-HSA-9658195 | Leishmania infection | 0.468248 | 0.330 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.470013 | 0.328 |
| R-HSA-167172 | Transcription of the HIV genome | 0.474491 | 0.324 |
| R-HSA-418555 | G alpha (s) signalling events | 0.477733 | 0.321 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.483335 | 0.316 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.483335 | 0.316 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.483335 | 0.316 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.485482 | 0.314 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.487701 | 0.312 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.487701 | 0.312 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.492031 | 0.308 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.496324 | 0.304 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.496324 | 0.304 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.500582 | 0.301 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.500582 | 0.301 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.500582 | 0.301 |
| R-HSA-380287 | Centrosome maturation | 0.504803 | 0.297 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.508990 | 0.293 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.516599 | 0.287 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.517257 | 0.286 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.517257 | 0.286 |
| R-HSA-69275 | G2/M Transition | 0.517865 | 0.286 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.521339 | 0.283 |
| R-HSA-109582 | Hemostasis | 0.523028 | 0.281 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.523061 | 0.281 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.525386 | 0.280 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.529400 | 0.276 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.537326 | 0.270 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.541239 | 0.267 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.545120 | 0.264 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.552783 | 0.257 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.553448 | 0.257 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.556566 | 0.254 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.560318 | 0.252 |
| R-HSA-202424 | Downstream TCR signaling | 0.567727 | 0.246 |
| R-HSA-6798695 | Neutrophil degranulation | 0.576755 | 0.239 |
| R-HSA-391251 | Protein folding | 0.578609 | 0.238 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.582176 | 0.235 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.589219 | 0.230 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.592696 | 0.227 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.596145 | 0.225 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.596145 | 0.225 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.599564 | 0.222 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.602954 | 0.220 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.606316 | 0.217 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.606316 | 0.217 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.616233 | 0.210 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.616233 | 0.210 |
| R-HSA-162906 | HIV Infection | 0.618964 | 0.208 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.622707 | 0.206 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.622707 | 0.206 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.622707 | 0.206 |
| R-HSA-418346 | Platelet homeostasis | 0.632214 | 0.199 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.638420 | 0.195 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.638420 | 0.195 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.638420 | 0.195 |
| R-HSA-449147 | Signaling by Interleukins | 0.640274 | 0.194 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.644521 | 0.191 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.644521 | 0.191 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.650521 | 0.187 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.656420 | 0.183 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.659332 | 0.181 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.665083 | 0.177 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.665083 | 0.177 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.665083 | 0.177 |
| R-HSA-913531 | Interferon Signaling | 0.666019 | 0.177 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.667923 | 0.175 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.667923 | 0.175 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.670738 | 0.173 |
| R-HSA-5688426 | Deubiquitination | 0.676904 | 0.169 |
| R-HSA-68875 | Mitotic Prophase | 0.679043 | 0.168 |
| R-HSA-3371556 | Cellular response to heat stress | 0.681765 | 0.166 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.682671 | 0.166 |
| R-HSA-212436 | Generic Transcription Pathway | 0.686572 | 0.163 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.689794 | 0.161 |
| R-HSA-416476 | G alpha (q) signalling events | 0.693954 | 0.159 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.695035 | 0.158 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.695035 | 0.158 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.695035 | 0.158 |
| R-HSA-194138 | Signaling by VEGF | 0.695035 | 0.158 |
| R-HSA-114608 | Platelet degranulation | 0.700188 | 0.155 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.701293 | 0.154 |
| R-HSA-1266738 | Developmental Biology | 0.702565 | 0.153 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.702732 | 0.153 |
| R-HSA-9843745 | Adipogenesis | 0.712695 | 0.147 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.715133 | 0.146 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.717551 | 0.144 |
| R-HSA-9679506 | SARS-CoV Infections | 0.720487 | 0.142 |
| R-HSA-5173105 | O-linked glycosylation | 0.729339 | 0.137 |
| R-HSA-8953854 | Metabolism of RNA | 0.734897 | 0.134 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.742841 | 0.129 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.742841 | 0.129 |
| R-HSA-2187338 | Visual phototransduction | 0.753580 | 0.123 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.755674 | 0.122 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.761850 | 0.118 |
| R-HSA-73887 | Death Receptor Signaling | 0.767871 | 0.115 |
| R-HSA-1989781 | PPARA activates gene expression | 0.769844 | 0.114 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.773741 | 0.111 |
| R-HSA-162587 | HIV Life Cycle | 0.773741 | 0.111 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.775665 | 0.110 |
| R-HSA-9711097 | Cellular response to starvation | 0.775665 | 0.110 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.779464 | 0.108 |
| R-HSA-1643685 | Disease | 0.788407 | 0.103 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.799244 | 0.097 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.804326 | 0.095 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.804326 | 0.095 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.804326 | 0.095 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.804326 | 0.095 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.804326 | 0.095 |
| R-HSA-388396 | GPCR downstream signalling | 0.806338 | 0.093 |
| R-HSA-168249 | Innate Immune System | 0.813453 | 0.090 |
| R-HSA-2559583 | Cellular Senescence | 0.815693 | 0.088 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.820361 | 0.086 |
| R-HSA-3781865 | Diseases of glycosylation | 0.821891 | 0.085 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.824383 | 0.084 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.824912 | 0.084 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.827883 | 0.082 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.832245 | 0.080 |
| R-HSA-68877 | Mitotic Prometaphase | 0.835091 | 0.078 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.839272 | 0.076 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.848622 | 0.071 |
| R-HSA-597592 | Post-translational protein modification | 0.850778 | 0.070 |
| R-HSA-68886 | M Phase | 0.856990 | 0.067 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.861050 | 0.065 |
| R-HSA-418990 | Adherens junctions interactions | 0.868014 | 0.061 |
| R-HSA-372790 | Signaling by GPCR | 0.868811 | 0.061 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.869499 | 0.061 |
| R-HSA-8951664 | Neddylation | 0.871366 | 0.060 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.876427 | 0.057 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.876765 | 0.057 |
| R-HSA-2262752 | Cellular responses to stress | 0.878259 | 0.056 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.878861 | 0.056 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.880921 | 0.055 |
| R-HSA-72312 | rRNA processing | 0.882947 | 0.054 |
| R-HSA-1280218 | Adaptive Immune System | 0.893165 | 0.049 |
| R-HSA-5668914 | Diseases of metabolism | 0.894568 | 0.048 |
| R-HSA-421270 | Cell-cell junction organization | 0.900564 | 0.045 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.910307 | 0.041 |
| R-HSA-112316 | Neuronal System | 0.920653 | 0.036 |
| R-HSA-446728 | Cell junction organization | 0.921163 | 0.036 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.923831 | 0.034 |
| R-HSA-9824446 | Viral Infection Pathways | 0.927902 | 0.032 |
| R-HSA-195721 | Signaling by WNT | 0.933635 | 0.030 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.946504 | 0.024 |
| R-HSA-8957322 | Metabolism of steroids | 0.946964 | 0.024 |
| R-HSA-1474244 | Extracellular matrix organization | 0.950073 | 0.022 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.957263 | 0.019 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.962463 | 0.017 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.968431 | 0.014 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.970288 | 0.013 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.971301 | 0.013 |
| R-HSA-418594 | G alpha (i) signalling events | 0.974361 | 0.011 |
| R-HSA-8978868 | Fatty acid metabolism | 0.974361 | 0.011 |
| R-HSA-392499 | Metabolism of proteins | 0.978143 | 0.010 |
| R-HSA-72766 | Translation | 0.978819 | 0.009 |
| R-HSA-5663205 | Infectious disease | 0.980795 | 0.008 |
| R-HSA-168256 | Immune System | 0.984562 | 0.007 |
| R-HSA-500792 | GPCR ligand binding | 0.994763 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 0.994854 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.995941 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.999977 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.825 | 0.207 | 2 | 0.827 |
CDC7 |
0.815 | 0.192 | 1 | 0.853 |
BMPR1B |
0.815 | 0.329 | 1 | 0.869 |
GRK1 |
0.811 | 0.214 | -2 | 0.724 |
DSTYK |
0.810 | 0.119 | 2 | 0.857 |
CLK3 |
0.809 | 0.108 | 1 | 0.750 |
NDR2 |
0.808 | 0.076 | -3 | 0.630 |
PIM3 |
0.808 | 0.083 | -3 | 0.644 |
IKKB |
0.808 | 0.082 | -2 | 0.676 |
IKKA |
0.807 | 0.178 | -2 | 0.688 |
MOS |
0.807 | 0.141 | 1 | 0.841 |
GCN2 |
0.806 | 0.047 | 2 | 0.791 |
CAMK2G |
0.805 | 0.166 | 2 | 0.850 |
GRK6 |
0.805 | 0.263 | 1 | 0.849 |
CAMK2B |
0.805 | 0.222 | 2 | 0.845 |
TGFBR1 |
0.804 | 0.269 | -2 | 0.829 |
BMPR1A |
0.803 | 0.325 | 1 | 0.840 |
NEK6 |
0.803 | 0.050 | -2 | 0.823 |
FAM20C |
0.801 | 0.141 | 2 | 0.626 |
LATS2 |
0.801 | 0.104 | -5 | 0.702 |
MAPKAPK2 |
0.801 | 0.124 | -3 | 0.557 |
TGFBR2 |
0.801 | 0.094 | -2 | 0.838 |
CAMK2A |
0.801 | 0.193 | 2 | 0.870 |
PLK3 |
0.799 | 0.279 | 2 | 0.755 |
ACVR2A |
0.799 | 0.265 | -2 | 0.839 |
ACVR2B |
0.798 | 0.264 | -2 | 0.842 |
PRPK |
0.798 | -0.028 | -1 | 0.808 |
HUNK |
0.798 | 0.097 | 2 | 0.755 |
ALK2 |
0.797 | 0.271 | -2 | 0.831 |
PIM1 |
0.797 | 0.071 | -3 | 0.597 |
RSK2 |
0.797 | 0.042 | -3 | 0.600 |
RAF1 |
0.797 | -0.044 | 1 | 0.817 |
NEK7 |
0.797 | -0.011 | -3 | 0.642 |
PLK1 |
0.797 | 0.190 | -2 | 0.832 |
GRK7 |
0.796 | 0.170 | 1 | 0.774 |
BMPR2 |
0.796 | 0.096 | -2 | 0.832 |
GRK4 |
0.795 | 0.117 | -2 | 0.785 |
CAMK1B |
0.795 | 0.006 | -3 | 0.668 |
CK2A2 |
0.795 | 0.252 | 1 | 0.772 |
ATM |
0.795 | 0.106 | 1 | 0.745 |
GRK5 |
0.795 | 0.077 | -3 | 0.657 |
TBK1 |
0.794 | -0.025 | 1 | 0.696 |
PRKD1 |
0.794 | 0.035 | -3 | 0.620 |
IKKE |
0.793 | -0.019 | 1 | 0.694 |
PLK2 |
0.793 | 0.375 | -3 | 0.840 |
NUAK2 |
0.793 | 0.015 | -3 | 0.645 |
ALK4 |
0.792 | 0.186 | -2 | 0.832 |
ATR |
0.792 | 0.010 | 1 | 0.795 |
CAMK2D |
0.791 | 0.066 | -3 | 0.632 |
LATS1 |
0.791 | 0.126 | -3 | 0.640 |
PKN3 |
0.791 | -0.020 | -3 | 0.629 |
NDR1 |
0.791 | -0.029 | -3 | 0.630 |
MTOR |
0.791 | -0.079 | 1 | 0.723 |
SRPK1 |
0.790 | 0.009 | -3 | 0.584 |
MLK1 |
0.790 | -0.013 | 2 | 0.774 |
CDKL1 |
0.790 | -0.014 | -3 | 0.626 |
PDHK4 |
0.790 | -0.141 | 1 | 0.807 |
ULK2 |
0.790 | -0.113 | 2 | 0.734 |
PRKD2 |
0.789 | 0.010 | -3 | 0.581 |
MARK4 |
0.789 | 0.035 | 4 | 0.841 |
SKMLCK |
0.788 | 0.004 | -2 | 0.719 |
ERK5 |
0.787 | -0.001 | 1 | 0.738 |
MAPKAPK3 |
0.787 | 0.016 | -3 | 0.586 |
P90RSK |
0.787 | -0.003 | -3 | 0.599 |
BCKDK |
0.787 | 0.037 | -1 | 0.759 |
GRK2 |
0.786 | 0.131 | -2 | 0.688 |
TSSK2 |
0.786 | 0.035 | -5 | 0.766 |
PRKX |
0.786 | 0.067 | -3 | 0.515 |
PDHK1 |
0.786 | -0.088 | 1 | 0.783 |
RSK3 |
0.785 | -0.021 | -3 | 0.611 |
DLK |
0.785 | 0.013 | 1 | 0.820 |
NLK |
0.784 | -0.078 | 1 | 0.749 |
AMPKA1 |
0.784 | -0.010 | -3 | 0.644 |
KIS |
0.784 | -0.011 | 1 | 0.587 |
RSK4 |
0.783 | 0.030 | -3 | 0.569 |
SRPK2 |
0.783 | 0.006 | -3 | 0.527 |
NIK |
0.783 | -0.088 | -3 | 0.675 |
ULK1 |
0.783 | -0.104 | -3 | 0.612 |
TSSK1 |
0.782 | 0.021 | -3 | 0.659 |
MST4 |
0.782 | -0.065 | 2 | 0.814 |
PKCD |
0.782 | -0.019 | 2 | 0.757 |
AMPKA2 |
0.781 | -0.004 | -3 | 0.619 |
CAMLCK |
0.781 | -0.066 | -2 | 0.723 |
CDKL5 |
0.781 | -0.032 | -3 | 0.615 |
MLK3 |
0.781 | 0.006 | 2 | 0.713 |
WNK1 |
0.780 | -0.104 | -2 | 0.711 |
CK2A1 |
0.780 | 0.197 | 1 | 0.762 |
MLK4 |
0.780 | 0.050 | 2 | 0.694 |
BRSK1 |
0.780 | 0.063 | -3 | 0.606 |
MSK1 |
0.780 | 0.018 | -3 | 0.578 |
RIPK3 |
0.779 | -0.151 | 3 | 0.517 |
MSK2 |
0.779 | -0.017 | -3 | 0.572 |
CHAK2 |
0.779 | -0.087 | -1 | 0.813 |
SRPK3 |
0.779 | -0.002 | -3 | 0.567 |
NEK9 |
0.779 | -0.111 | 2 | 0.794 |
GRK3 |
0.779 | 0.127 | -2 | 0.656 |
TLK2 |
0.778 | 0.074 | 1 | 0.776 |
DAPK2 |
0.778 | -0.076 | -3 | 0.665 |
P70S6KB |
0.778 | -0.050 | -3 | 0.611 |
NUAK1 |
0.778 | -0.031 | -3 | 0.606 |
PKN2 |
0.778 | -0.089 | -3 | 0.630 |
PKACB |
0.778 | 0.009 | -2 | 0.562 |
QSK |
0.778 | 0.026 | 4 | 0.816 |
ICK |
0.777 | -0.038 | -3 | 0.642 |
ANKRD3 |
0.777 | -0.083 | 1 | 0.819 |
AURC |
0.776 | -0.032 | -2 | 0.542 |
HIPK4 |
0.776 | -0.054 | 1 | 0.723 |
CLK2 |
0.776 | 0.035 | -3 | 0.585 |
CHK1 |
0.776 | 0.046 | -3 | 0.654 |
PKR |
0.776 | 0.021 | 1 | 0.805 |
PKACG |
0.776 | -0.058 | -2 | 0.614 |
MARK3 |
0.775 | 0.058 | 4 | 0.777 |
MLK2 |
0.774 | -0.111 | 2 | 0.772 |
TTBK2 |
0.774 | -0.098 | 2 | 0.658 |
MEK1 |
0.773 | -0.020 | 2 | 0.805 |
PASK |
0.773 | 0.100 | -3 | 0.655 |
MARK2 |
0.773 | 0.056 | 4 | 0.750 |
CDK8 |
0.773 | -0.039 | 1 | 0.571 |
YSK4 |
0.772 | -0.037 | 1 | 0.755 |
SIK |
0.772 | -0.001 | -3 | 0.578 |
MASTL |
0.772 | -0.225 | -2 | 0.706 |
DNAPK |
0.772 | 0.057 | 1 | 0.655 |
CAMK4 |
0.771 | -0.101 | -3 | 0.617 |
MARK1 |
0.771 | 0.074 | 4 | 0.800 |
TLK1 |
0.771 | 0.044 | -2 | 0.845 |
PRKD3 |
0.771 | -0.046 | -3 | 0.579 |
WNK3 |
0.770 | -0.235 | 1 | 0.766 |
PKCB |
0.770 | -0.049 | 2 | 0.707 |
MYLK4 |
0.769 | -0.042 | -2 | 0.643 |
CDK1 |
0.769 | -0.014 | 1 | 0.561 |
PERK |
0.769 | -0.006 | -2 | 0.823 |
JNK3 |
0.769 | 0.019 | 1 | 0.556 |
NIM1 |
0.769 | -0.105 | 3 | 0.627 |
AURA |
0.769 | -0.020 | -2 | 0.527 |
PAK1 |
0.769 | -0.072 | -2 | 0.636 |
IRE1 |
0.768 | -0.131 | 1 | 0.766 |
JNK2 |
0.768 | 0.021 | 1 | 0.524 |
CLK4 |
0.768 | -0.033 | -3 | 0.588 |
BRAF |
0.768 | 0.033 | -4 | 0.832 |
SMG1 |
0.767 | -0.009 | 1 | 0.744 |
DRAK1 |
0.767 | -0.000 | 1 | 0.843 |
QIK |
0.766 | -0.082 | -3 | 0.632 |
MELK |
0.766 | -0.091 | -3 | 0.605 |
IRE2 |
0.766 | -0.096 | 2 | 0.683 |
CLK1 |
0.765 | -0.039 | -3 | 0.578 |
CDK5 |
0.765 | -0.039 | 1 | 0.600 |
RIPK1 |
0.764 | -0.231 | 1 | 0.792 |
CDK19 |
0.764 | -0.052 | 1 | 0.530 |
PKCG |
0.764 | -0.086 | 2 | 0.702 |
MEKK3 |
0.764 | -0.047 | 1 | 0.791 |
AURB |
0.764 | -0.060 | -2 | 0.539 |
PIM2 |
0.764 | -0.027 | -3 | 0.577 |
BRSK2 |
0.763 | -0.076 | -3 | 0.612 |
CAMK1G |
0.763 | -0.053 | -3 | 0.579 |
PKCA |
0.763 | -0.072 | 2 | 0.699 |
AKT2 |
0.763 | -0.042 | -3 | 0.536 |
DYRK2 |
0.762 | -0.051 | 1 | 0.628 |
MNK2 |
0.762 | -0.108 | -2 | 0.649 |
HRI |
0.761 | -0.098 | -2 | 0.826 |
PHKG1 |
0.761 | -0.121 | -3 | 0.617 |
PKCH |
0.761 | -0.093 | 2 | 0.686 |
CK1E |
0.761 | -0.051 | -3 | 0.397 |
MAPKAPK5 |
0.761 | -0.087 | -3 | 0.550 |
NEK2 |
0.761 | -0.137 | 2 | 0.770 |
PKACA |
0.761 | -0.020 | -2 | 0.517 |
CAMK1D |
0.761 | -0.002 | -3 | 0.532 |
PAK3 |
0.761 | -0.132 | -2 | 0.633 |
CDK2 |
0.760 | -0.055 | 1 | 0.651 |
DCAMKL1 |
0.760 | -0.059 | -3 | 0.598 |
VRK2 |
0.760 | -0.256 | 1 | 0.814 |
SSTK |
0.760 | -0.008 | 4 | 0.809 |
MEKK1 |
0.759 | -0.089 | 1 | 0.762 |
PINK1 |
0.759 | -0.106 | 1 | 0.762 |
PKG2 |
0.759 | -0.074 | -2 | 0.556 |
MEKK2 |
0.758 | -0.048 | 2 | 0.759 |
MNK1 |
0.758 | -0.103 | -2 | 0.667 |
P38G |
0.758 | -0.017 | 1 | 0.461 |
PKCZ |
0.758 | -0.121 | 2 | 0.738 |
SGK3 |
0.757 | -0.068 | -3 | 0.584 |
P38B |
0.757 | -0.018 | 1 | 0.542 |
CHAK1 |
0.757 | -0.174 | 2 | 0.696 |
TAO3 |
0.757 | -0.046 | 1 | 0.769 |
PLK4 |
0.757 | -0.108 | 2 | 0.571 |
NEK5 |
0.756 | -0.116 | 1 | 0.789 |
ZAK |
0.756 | -0.110 | 1 | 0.751 |
ERK1 |
0.756 | -0.035 | 1 | 0.527 |
PAK6 |
0.756 | -0.084 | -2 | 0.559 |
ERK2 |
0.756 | -0.047 | 1 | 0.574 |
HIPK2 |
0.755 | -0.033 | 1 | 0.534 |
P38A |
0.755 | -0.044 | 1 | 0.612 |
CDK7 |
0.755 | -0.094 | 1 | 0.579 |
PAK2 |
0.755 | -0.128 | -2 | 0.620 |
GAK |
0.755 | 0.028 | 1 | 0.809 |
CAMKK1 |
0.754 | -0.051 | -2 | 0.689 |
CDK3 |
0.754 | -0.027 | 1 | 0.486 |
MST2 |
0.754 | 0.026 | 1 | 0.791 |
CDK13 |
0.753 | -0.085 | 1 | 0.548 |
MEK5 |
0.753 | -0.218 | 2 | 0.775 |
CK1D |
0.753 | -0.049 | -3 | 0.340 |
SNRK |
0.752 | -0.199 | 2 | 0.612 |
NEK8 |
0.752 | -0.085 | 2 | 0.761 |
SMMLCK |
0.751 | -0.080 | -3 | 0.628 |
DCAMKL2 |
0.751 | -0.082 | -3 | 0.622 |
GSK3A |
0.751 | 0.019 | 4 | 0.478 |
CK1G1 |
0.750 | -0.087 | -3 | 0.385 |
CDK18 |
0.750 | -0.068 | 1 | 0.513 |
HIPK1 |
0.750 | -0.062 | 1 | 0.641 |
P70S6K |
0.750 | -0.082 | -3 | 0.546 |
AKT1 |
0.749 | -0.058 | -3 | 0.541 |
JNK1 |
0.749 | 0.007 | 1 | 0.519 |
MST3 |
0.749 | -0.109 | 2 | 0.785 |
DYRK4 |
0.748 | -0.033 | 1 | 0.543 |
PRP4 |
0.748 | -0.084 | -3 | 0.557 |
CK1A2 |
0.748 | -0.063 | -3 | 0.346 |
DYRK1A |
0.748 | -0.072 | 1 | 0.637 |
CAMKK2 |
0.748 | -0.067 | -2 | 0.672 |
DAPK3 |
0.747 | -0.042 | -3 | 0.608 |
P38D |
0.747 | -0.010 | 1 | 0.458 |
WNK4 |
0.747 | -0.184 | -2 | 0.688 |
EEF2K |
0.747 | -0.033 | 3 | 0.629 |
TAK1 |
0.746 | -0.021 | 1 | 0.794 |
ERK7 |
0.746 | 0.015 | 2 | 0.571 |
PKCT |
0.745 | -0.119 | 2 | 0.693 |
GCK |
0.745 | -0.052 | 1 | 0.794 |
CDK9 |
0.745 | -0.107 | 1 | 0.554 |
CDK17 |
0.745 | -0.071 | 1 | 0.467 |
GSK3B |
0.745 | -0.030 | 4 | 0.469 |
PHKG2 |
0.745 | -0.136 | -3 | 0.604 |
TTBK1 |
0.744 | -0.137 | 2 | 0.573 |
CAMK1A |
0.744 | -0.029 | -3 | 0.506 |
LKB1 |
0.744 | -0.109 | -3 | 0.611 |
MPSK1 |
0.744 | -0.093 | 1 | 0.748 |
CDK12 |
0.744 | -0.094 | 1 | 0.521 |
DAPK1 |
0.743 | -0.037 | -3 | 0.596 |
TAO2 |
0.742 | -0.136 | 2 | 0.804 |
IRAK4 |
0.741 | -0.215 | 1 | 0.760 |
AKT3 |
0.741 | -0.044 | -3 | 0.486 |
MST1 |
0.741 | -0.057 | 1 | 0.769 |
DYRK1B |
0.740 | -0.072 | 1 | 0.577 |
SGK1 |
0.740 | -0.031 | -3 | 0.477 |
DYRK3 |
0.740 | -0.072 | 1 | 0.650 |
TNIK |
0.740 | -0.076 | 3 | 0.635 |
TTK |
0.739 | 0.077 | -2 | 0.848 |
CHK2 |
0.739 | -0.062 | -3 | 0.494 |
PKCI |
0.738 | -0.125 | 2 | 0.713 |
CDK16 |
0.738 | -0.057 | 1 | 0.480 |
MINK |
0.738 | -0.103 | 1 | 0.764 |
PDHK3_TYR |
0.738 | 0.209 | 4 | 0.909 |
PKCE |
0.738 | -0.083 | 2 | 0.684 |
HIPK3 |
0.737 | -0.111 | 1 | 0.622 |
NEK11 |
0.737 | -0.225 | 1 | 0.763 |
SBK |
0.737 | -0.012 | -3 | 0.448 |
PDK1 |
0.737 | -0.144 | 1 | 0.742 |
OSR1 |
0.736 | 0.001 | 2 | 0.766 |
IRAK1 |
0.736 | -0.256 | -1 | 0.693 |
NEK4 |
0.736 | -0.196 | 1 | 0.752 |
PAK5 |
0.736 | -0.112 | -2 | 0.502 |
SLK |
0.736 | -0.080 | -2 | 0.613 |
CDK14 |
0.736 | -0.097 | 1 | 0.560 |
HGK |
0.735 | -0.127 | 3 | 0.621 |
MRCKA |
0.735 | -0.064 | -3 | 0.571 |
ROCK2 |
0.735 | -0.053 | -3 | 0.594 |
VRK1 |
0.734 | -0.155 | 2 | 0.762 |
PAK4 |
0.734 | -0.098 | -2 | 0.518 |
MAK |
0.734 | -0.022 | -2 | 0.612 |
MRCKB |
0.734 | -0.070 | -3 | 0.562 |
CDK10 |
0.734 | -0.081 | 1 | 0.546 |
MAP2K6_TYR |
0.733 | 0.159 | -1 | 0.843 |
NEK1 |
0.733 | -0.181 | 1 | 0.760 |
HPK1 |
0.732 | -0.120 | 1 | 0.780 |
PKN1 |
0.731 | -0.107 | -3 | 0.555 |
PDHK4_TYR |
0.731 | 0.139 | 2 | 0.839 |
BMPR2_TYR |
0.731 | 0.145 | -1 | 0.839 |
LRRK2 |
0.731 | -0.192 | 2 | 0.801 |
TXK |
0.731 | 0.204 | 1 | 0.858 |
LOK |
0.730 | -0.140 | -2 | 0.647 |
MEK2 |
0.730 | -0.176 | 2 | 0.763 |
KHS2 |
0.729 | -0.079 | 1 | 0.768 |
MAP3K15 |
0.729 | -0.209 | 1 | 0.726 |
KHS1 |
0.728 | -0.113 | 1 | 0.748 |
CDK6 |
0.728 | -0.081 | 1 | 0.527 |
PDHK1_TYR |
0.728 | 0.124 | -1 | 0.849 |
CDK4 |
0.728 | -0.078 | 1 | 0.508 |
CK1A |
0.728 | -0.042 | -3 | 0.267 |
MEKK6 |
0.727 | -0.236 | 1 | 0.753 |
BUB1 |
0.727 | -0.066 | -5 | 0.689 |
MOK |
0.727 | -0.052 | 1 | 0.676 |
DMPK1 |
0.727 | -0.042 | -3 | 0.580 |
MAP2K4_TYR |
0.727 | 0.020 | -1 | 0.833 |
EPHA6 |
0.727 | 0.081 | -1 | 0.838 |
RIPK2 |
0.726 | -0.240 | 1 | 0.713 |
STK33 |
0.725 | -0.174 | 2 | 0.573 |
BIKE |
0.724 | 0.005 | 1 | 0.681 |
ALPHAK3 |
0.724 | 0.024 | -1 | 0.750 |
YSK1 |
0.724 | -0.156 | 2 | 0.767 |
TESK1_TYR |
0.723 | -0.093 | 3 | 0.660 |
PBK |
0.722 | -0.090 | 1 | 0.716 |
EPHB4 |
0.720 | 0.045 | -1 | 0.827 |
MAP2K7_TYR |
0.720 | -0.128 | 2 | 0.812 |
PINK1_TYR |
0.719 | -0.109 | 1 | 0.804 |
CRIK |
0.719 | -0.058 | -3 | 0.540 |
ROCK1 |
0.719 | -0.078 | -3 | 0.569 |
PKG1 |
0.718 | -0.101 | -2 | 0.465 |
INSRR |
0.718 | 0.039 | 3 | 0.525 |
EPHA4 |
0.717 | 0.059 | 2 | 0.749 |
YES1 |
0.715 | 0.046 | -1 | 0.776 |
PKMYT1_TYR |
0.715 | -0.178 | 3 | 0.620 |
RET |
0.715 | -0.066 | 1 | 0.754 |
EPHB2 |
0.715 | 0.079 | -1 | 0.807 |
SRMS |
0.714 | 0.085 | 1 | 0.849 |
FER |
0.714 | 0.014 | 1 | 0.836 |
ITK |
0.714 | 0.034 | -1 | 0.756 |
EPHB1 |
0.713 | 0.032 | 1 | 0.837 |
ABL2 |
0.713 | -0.014 | -1 | 0.761 |
ASK1 |
0.712 | -0.159 | 1 | 0.713 |
STLK3 |
0.712 | -0.088 | 1 | 0.726 |
FGR |
0.712 | -0.031 | 1 | 0.827 |
FYN |
0.711 | 0.117 | -1 | 0.748 |
NEK3 |
0.711 | -0.249 | 1 | 0.699 |
BLK |
0.711 | 0.055 | -1 | 0.781 |
LCK |
0.711 | 0.031 | -1 | 0.775 |
HASPIN |
0.711 | -0.094 | -1 | 0.640 |
MYO3B |
0.710 | -0.143 | 2 | 0.769 |
EPHB3 |
0.710 | -0.009 | -1 | 0.812 |
LIMK2_TYR |
0.710 | -0.178 | -3 | 0.670 |
MYO3A |
0.710 | -0.139 | 1 | 0.751 |
TYRO3 |
0.710 | -0.119 | 3 | 0.569 |
CSF1R |
0.709 | -0.063 | 3 | 0.542 |
TEC |
0.709 | 0.027 | -1 | 0.690 |
BMX |
0.708 | 0.019 | -1 | 0.688 |
JAK3 |
0.708 | -0.067 | 1 | 0.746 |
YANK3 |
0.708 | -0.094 | 2 | 0.375 |
CK1G3 |
0.708 | -0.034 | -3 | 0.229 |
ROS1 |
0.708 | -0.163 | 3 | 0.549 |
HCK |
0.707 | -0.031 | -1 | 0.773 |
AAK1 |
0.707 | 0.021 | 1 | 0.576 |
TAO1 |
0.707 | -0.167 | 1 | 0.686 |
DDR1 |
0.706 | -0.150 | 4 | 0.842 |
TYK2 |
0.706 | -0.203 | 1 | 0.745 |
MST1R |
0.706 | -0.182 | 3 | 0.559 |
LIMK1_TYR |
0.705 | -0.251 | 2 | 0.796 |
PTK2 |
0.705 | 0.119 | -1 | 0.783 |
FGFR2 |
0.705 | -0.049 | 3 | 0.553 |
ABL1 |
0.704 | -0.054 | -1 | 0.744 |
EPHA7 |
0.704 | 0.005 | 2 | 0.744 |
KIT |
0.704 | -0.059 | 3 | 0.543 |
FLT1 |
0.704 | 0.010 | -1 | 0.827 |
EPHA5 |
0.703 | 0.057 | 2 | 0.735 |
JAK2 |
0.703 | -0.194 | 1 | 0.730 |
FLT3 |
0.702 | -0.082 | 3 | 0.553 |
MERTK |
0.702 | -0.030 | 3 | 0.535 |
SYK |
0.701 | 0.110 | -1 | 0.771 |
PDGFRB |
0.700 | -0.128 | 3 | 0.553 |
BTK |
0.700 | -0.064 | -1 | 0.718 |
EPHA3 |
0.699 | -0.035 | 2 | 0.718 |
MET |
0.699 | -0.055 | 3 | 0.521 |
EPHA8 |
0.699 | 0.032 | -1 | 0.790 |
EGFR |
0.699 | 0.052 | 1 | 0.651 |
NTRK1 |
0.699 | -0.055 | -1 | 0.789 |
NEK10_TYR |
0.699 | -0.111 | 1 | 0.641 |
LYN |
0.698 | 0.003 | 3 | 0.489 |
ERBB2 |
0.698 | -0.050 | 1 | 0.734 |
KDR |
0.697 | -0.123 | 3 | 0.501 |
PTK6 |
0.697 | -0.050 | -1 | 0.680 |
INSR |
0.697 | -0.068 | 3 | 0.509 |
FGFR3 |
0.696 | -0.042 | 3 | 0.525 |
SRC |
0.696 | 0.033 | -1 | 0.734 |
FRK |
0.696 | -0.034 | -1 | 0.799 |
TEK |
0.695 | -0.162 | 3 | 0.513 |
TNK2 |
0.695 | -0.169 | 3 | 0.482 |
FGFR1 |
0.694 | -0.135 | 3 | 0.528 |
LTK |
0.693 | -0.100 | 3 | 0.500 |
AXL |
0.693 | -0.147 | 3 | 0.529 |
NTRK2 |
0.693 | -0.103 | 3 | 0.511 |
ALK |
0.692 | -0.132 | 3 | 0.484 |
NTRK3 |
0.692 | -0.062 | -1 | 0.746 |
FLT4 |
0.691 | -0.107 | 3 | 0.515 |
TNNI3K_TYR |
0.691 | -0.149 | 1 | 0.741 |
PTK2B |
0.691 | -0.019 | -1 | 0.705 |
CSK |
0.691 | -0.002 | 2 | 0.738 |
EPHA2 |
0.690 | 0.019 | -1 | 0.771 |
CK1G2 |
0.690 | -0.056 | -3 | 0.311 |
FGFR4 |
0.690 | 0.012 | -1 | 0.744 |
TNK1 |
0.689 | -0.216 | 3 | 0.558 |
WEE1_TYR |
0.689 | -0.126 | -1 | 0.705 |
ERBB4 |
0.689 | 0.022 | 1 | 0.696 |
JAK1 |
0.688 | -0.179 | 1 | 0.692 |
PDGFRA |
0.688 | -0.222 | 3 | 0.555 |
MATK |
0.688 | -0.063 | -1 | 0.692 |
IGF1R |
0.688 | -0.035 | 3 | 0.470 |
EPHA1 |
0.688 | -0.134 | 3 | 0.494 |
DDR2 |
0.687 | -0.115 | 3 | 0.486 |
YANK2 |
0.679 | -0.105 | 2 | 0.398 |
MUSK |
0.673 | -0.138 | 1 | 0.655 |
ZAP70 |
0.667 | -0.032 | -1 | 0.679 |
FES |
0.665 | -0.076 | -1 | 0.650 |