Motif 715 (n=169)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
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A0A0A6YYG9 | ARPC4-TTLL3 | S42 | ochoa | Protein ARPC4-TTLL3 | None |
A4UGR9 | XIRP2 | S117 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
I3L4J1 | None | S114 | ochoa | vesicle-fusing ATPase (EC 3.6.4.6) | (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000256|ARBA:ARBA00059988}. |
M0R2C6 | None | S196 | ochoa | serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (Seryl-tRNA(Ser/Sec) synthetase) | None |
O14744 | PRMT5 | S335 | psp | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}. |
O15078 | CEP290 | S1610 | ochoa | Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) | Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973). {ECO:0000250|UniProtKB:Q6A078, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17705300, ECO:0000269|PubMed:18694559, ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:25552655}. |
O15085 | ARHGEF11 | S213 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
O43823 | AKAP8 | S644 | ochoa | A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) | Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}. |
O60784 | TOM1 | S355 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
O75469 | NR1I2 | S208 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
O75676 | RPS6KA4 | S324 | psp | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
O95394 | PGM3 | S64 | ochoa | Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3) | Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. {ECO:0000303|PubMed:24589341, ECO:0000303|PubMed:24698316, ECO:0000303|PubMed:24931394}. |
P00519 | ABL1 | S619 | ochoa|psp | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
P03372 | ESR1 | S46 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
P07332 | FES | S408 | ochoa | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}. |
P11055 | MYH3 | S1336 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
P12882 | MYH1 | S1339 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
P12883 | MYH7 | S1335 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P13533 | MYH6 | S1337 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
P13535 | MYH8 | S1338 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
P14625 | HSP90B1 | S514 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
P16157 | ANK1 | S1593 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
P17661 | DES | S358 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
P19484 | TFEB | S211 | psp | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
P20810 | CAST | S311 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
P22059 | OSBP | S338 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
P29374 | ARID4A | S275 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
P35579 | MYH9 | S1803 | psp | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
P35749 | MYH11 | S1667 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
P36897 | TGFBR1 | S360 | ochoa | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis (PubMed:33914044). The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}. |
P36955 | SERPINF1 | S114 | psp | Pigment epithelium-derived factor (PEDF) (Cell proliferation-inducing gene 35 protein) (EPC-1) (Serpin F1) | Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}. |
P37059 | HSD17B2 | S234 | ochoa | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) | Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}. |
P41227 | NAA10 | S182 | ochoa|psp | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
P43004 | SLC1A2 | S521 | ochoa | Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P43006, ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911}. |
P43490 | NAMPT | S470 | ochoa | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}. |
P46100 | ATRX | S1253 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
P46939 | UTRN | S1795 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
P46939 | UTRN | S2111 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
P48681 | NES | S325 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
P49321 | NASP | S610 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
P51956 | NEK3 | S462 | ochoa | Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3) | Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286, ECO:0000269|PubMed:17297458}. |
P52179 | MYOM1 | S470 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
P52701 | MSH6 | S330 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
P52789 | HK2 | S122 | ochoa | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
P55072 | VCP | S416 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
P59998 | ARPC4 | S42 | ochoa | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
P78358 | CTAG1A | S108 | ochoa | Cancer/testis antigen 1 (Autoimmunogenic cancer/testis antigen NY-ESO-1) (Cancer/testis antigen 6.1) (CT6.1) (L antigen family member 2) (LAGE-2) | None |
P78410 | BTN3A2 | S282 | ochoa | Butyrophilin subfamily 3 member A2 | Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells. {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}. |
Q05086 | UBE3A | S93 | ochoa | Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990, PubMed:30020076). Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990, PubMed:30020076). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:O08759, ECO:0000269|PubMed:10373495, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:19204938, ECO:0000269|PubMed:19233847, ECO:0000269|PubMed:19325566, ECO:0000269|PubMed:19591933, ECO:0000269|PubMed:22645313, ECO:0000269|PubMed:24273172, ECO:0000269|PubMed:24728990, ECO:0000269|PubMed:30020076}.; FUNCTION: (Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. {ECO:0000269|PubMed:8380895}. |
Q07157 | TJP1 | S878 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q08378 | GOLGA3 | S385 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
Q08945 | SSRP1 | S375 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
Q08AE8 | SPIRE1 | S169 | ochoa | Protein spire homolog 1 (Spir-1) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}. |
Q12893 | TMEM115 | S266 | ochoa | Transmembrane protein 115 (Placental protein 6) (Protein PL6) | May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. {ECO:0000269|PubMed:24806965}. |
Q12904 | AIMP1 | S106 | ochoa | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)] | Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550). {ECO:0000250|UniProtKB:P31230, ECO:0000269|PubMed:10358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:12237313, ECO:0000269|PubMed:19362550}. |
Q12929 | EPS8 | S775 | psp | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
Q13568 | IRF5 | S446 | ochoa|psp | Interferon regulatory factor 5 (IRF-5) | Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}. |
Q13625 | TP53BP2 | S296 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
Q13772 | NCOA4 | S186 | ochoa | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) | Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}. |
Q14160 | SCRIB | S1220 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q15005 | SPCS2 | S192 | ochoa | Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) | Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). {ECO:0000250|UniProtKB:Q04969, ECO:0000269|PubMed:34388369}. |
Q15424 | SAFB | T194 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
Q15561 | TEAD4 | S253 | ochoa | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
Q15643 | TRIP11 | S1341 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
Q15751 | HERC1 | S1333 | ochoa | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
Q53GG5 | PDLIM3 | S89 | ochoa | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) | May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}. |
Q5SR56 | MFSD14B | S464 | ochoa | Hippocampus abundant transcript-like protein 1 (Major facilitator superfamily domain-containing 14B) | None |
Q5T8I3 | EEIG2 | S313 | ochoa | EEIG family member 2 (EEIG2) | None |
Q5T8P6 | RBM26 | S92 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
Q5UIP0 | RIF1 | S1494 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
Q5VT52 | RPRD2 | S1069 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
Q5VYS8 | TUT7 | S939 | ochoa | Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}. |
Q5VZ89 | DENND4C | S1205 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
Q5VZ89 | DENND4C | S1382 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
Q5W0B1 | OBI1 | S525 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
Q5XKL5 | BTBD8 | S876 | ochoa | BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis) (APache) | Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission. {ECO:0000250|UniProtKB:Q80TK0}. |
Q6BDS2 | BLTP3A | S936 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
Q6DT37 | CDC42BPG | S480 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
Q6R327 | RICTOR | S1177 | ochoa|psp | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
Q7L2Z9 | CENPQ | S138 | ochoa|psp | Centromere protein Q (CENP-Q) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}. |
Q7Z2Z1 | TICRR | S1583 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
Q7Z4V5 | HDGFL2 | S595 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
Q7Z5J4 | RAI1 | S846 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
Q7Z736 | PLEKHH3 | S30 | ochoa | Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3) | None |
Q86UP2 | KTN1 | S1310 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
Q86UX7 | FERMT3 | S132 | ochoa | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
Q86V48 | LUZP1 | S608 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
Q86X27 | RALGPS2 | S23 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
Q86XD5 | FAM131B | S105 | ochoa | Protein FAM131B | None |
Q86YC2 | PALB2 | S357 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
Q8IVF2 | AHNAK2 | S4634 | ochoa | Protein AHNAK2 | None |
Q8N201 | INTS1 | S288 | ochoa | Integrator complex subunit 1 (Int1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
Q8NCY6 | MSANTD4 | S286 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 4 (Myb/SANT-like DNA-binding domain containing 4 with coiled-coils) | None |
Q8NDI1 | EHBP1 | S577 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
Q8NF91 | SYNE1 | S6268 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
Q8NFA0 | USP32 | S1422 | ochoa | Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) | Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874). {ECO:0000269|PubMed:36476874}. |
Q8WUM0 | NUP133 | S472 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
Q8WVT3 | TRAPPC12 | S78 | ochoa | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}. |
Q8WZ75 | ROBO4 | S657 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
Q92878 | RAD50 | S470 | ochoa | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
Q96CV9 | OPTN | S170 | ochoa | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
Q96JM3 | CHAMP1 | S651 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
Q96L73 | NSD1 | S571 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
Q96NR8 | RDH12 | S174 | ochoa | Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2) | Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448). Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (PubMed:15865448, PubMed:19686838). May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). Has no dehydrogenase activity towards steroids (PubMed:12226107, PubMed:15865448). {ECO:0000269|PubMed:12226107, ECO:0000269|PubMed:15865448, ECO:0000269|PubMed:19686838}. |
Q96RG2 | PASK | S1277 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
Q96T88 | UHRF1 | S119 | ochoa | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
Q99623 | PHB2 | S119 | ochoa | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}. |
Q99698 | LYST | S2152 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
Q9BPZ3 | PAIP2 | S100 | ochoa | Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2) | Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. {ECO:0000269|PubMed:11172725}. |
Q9BQF6 | SENP7 | S436 | ochoa | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}. |
Q9BRA0 | NAA38 | S29 | ochoa | N-alpha-acetyltransferase 38, NatC auxiliary subunit (LSM domain-containing protein 1) (Phosphonoformate immuno-associated protein 2) | Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
Q9BRP8 | PYM1 | S177 | ochoa | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}. |
Q9BRV8 | SIKE1 | S133 | psp | Suppressor of IKBKE 1 (Suppressor of IKK-epsilon) | Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (PubMed:16281057). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:30622739). {ECO:0000269|PubMed:16281057, ECO:0000269|PubMed:30622739}. |
Q9BU19 | ZNF692 | S146 | ochoa | Zinc finger protein 692 (AICAR responsive element binding protein) | May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. {ECO:0000269|PubMed:17097062, ECO:0000269|PubMed:21910974}. |
Q9BWH6 | RPAP1 | S264 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
Q9BWM7 | SFXN3 | S290 | ochoa | Sideroflexin-3 | Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). {ECO:0000269|PubMed:30442778}. |
Q9C0C2 | TNKS1BP1 | S851 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9H0A0 | NAT10 | S957 | ochoa | RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) | RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}. |
Q9H246 | C1orf21 | S93 | ochoa | Uncharacterized protein C1orf21 (Cell proliferation-inducing gene 13 protein) | None |
Q9H4E7 | DEF6 | S387 | ochoa | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}. |
Q9H981 | ACTR8 | S412 | ochoa | Actin-related protein 8 (hArp8) (INO80 complex subunit N) | Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. |
Q9HB58 | SP110 | S248 | ochoa | Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) | Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). |
Q9HCE1 | MOV10 | S973 | ochoa | Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) | 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}. |
Q9HD26 | GOPC | S151 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}. |
Q9NP74 | PALMD | S112 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
Q9NP81 | SARS2 | S126 | ochoa | Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). {ECO:0000250|UniProtKB:Q9N0F3}. |
Q9NRA8 | EIF4ENIF1 | S374 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
Q9NRF8 | CTPS2 | S563 | ochoa | CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2) | Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. {ECO:0000269|PubMed:10899599, ECO:0000269|PubMed:16179339}. |
Q9NTI5 | PDS5B | S1257 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
Q9NUQ6 | SPATS2L | S116 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
Q9NYL9 | TMOD3 | S59 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
Q9P1Y5 | CAMSAP3 | S863 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
Q9P206 | NHSL3 | S93 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
Q9P246 | STIM2 | S343 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
Q9P253 | VPS18 | S829 | ochoa | Vacuolar protein sorting-associated protein 18 homolog (hVPS18) | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). {ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25783203}. |
Q9P2G1 | ANKIB1 | S891 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
Q9UDT6 | CLIP2 | S923 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
Q9UHR4 | BAIAP2L1 | S317 | ochoa | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
Q9UKG1 | APPL1 | S689 | ochoa | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}. |
Q9UKX2 | MYH2 | S1341 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
Q9UN37 | VPS4A | S90 | ochoa | Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) | Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization, chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (PubMed:33186545). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Critical for normal erythroblast cytokinesis and correct erythropoiesis (PubMed:33186543). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:15075231, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:33186543, ECO:0000269|PubMed:33186545}.; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:11595185}. |
Q9UNE7 | STUB1 | S137 | ochoa | E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) | E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462, PubMed:26265139). Plays a role in the maintenance of mitochondrial morphology and promotes mitophagic removal of dysfunctional mitochondria; thereby acts as a protector against apoptosis in response to cellular stress (By similarity). Negatively regulates vascular smooth muscle contraction, via degradation of the transcriptional activator MYOCD and subsequent loss of transcription of genes involved in vascular smooth muscle contraction (By similarity). Promotes survival and proliferation of cardiac smooth muscle cells via ubiquitination and degradation of FOXO1, resulting in subsequent repression of FOXO1-mediated transcription of pro-apoptotic genes (PubMed:19483080). Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes (PubMed:20724525). Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3 (PubMed:30980393). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (PubMed:15466472). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (PubMed:10330192, PubMed:11146632, PubMed:15466472). Ubiquitinates CHRNA3 targeting it for endoplasmic reticulum-associated degradation in cortical neurons, as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Ubiquitinates and promotes ESR1 proteasomal degradation in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (PubMed:11557750, PubMed:23990462). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (PubMed:19713937). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (PubMed:28813410). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). Plays a role in the degradation of TP53 (PubMed:26634371). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Ubiquitinates PPARG in macrophages playing a role in M2 macrophages polarization and angiogenesis (By similarity). {ECO:0000250|UniProtKB:A6HD62, ECO:0000250|UniProtKB:Q9WUD1, ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11146632, ECO:0000269|PubMed:11557750, ECO:0000269|PubMed:15466472, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:19567782, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20724525, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24043303, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30980393}. |
Q9UP95 | SLC12A4 | S88 | ochoa | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}. |
Q9UPN4 | CEP131 | S525 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
Q9UPN7 | PPP6R1 | S530 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
Q9UPV0 | CEP164 | S544 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
Q9UQE7 | SMC3 | S787 | ochoa|psp | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
Q9UQN3 | CHMP2B | S187 | ochoa | Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. |
Q9UQR1 | ZNF148 | S698 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
Q9Y250 | LZTS1 | S250 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
Q9Y2K6 | USP20 | S263 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
Q9Y448 | KNSTRN | S241 | ochoa | Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1) | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}. |
Q9Y4B5 | MTCL1 | S208 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
Q9Y4J8 | DTNA | S637 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
Q9Y5B9 | SUPT16H | S899 | ochoa | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
Q9Y6D9 | MAD1L1 | S214 | psp | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
P50454 | SERPINH1 | S138 | Sugiyama | Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) | Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. |
P61313 | RPL15 | S118 | Sugiyama | Large ribosomal subunit protein eL15 (60S ribosomal protein L15) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
O95881 | TXNDC12 | S136 | Sugiyama | Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19) | Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity. {ECO:0000269|PubMed:12761212}. |
O15075 | DCLK1 | S160 | Sugiyama | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
Q7Z4S6 | KIF21A | S705 | Sugiyama | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
P26038 | MSN | S144 | Sugiyama | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
P57081 | WDR4 | S128 | Sugiyama | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (Protein Wuho homolog) (hWH) (WD repeat-containing protein 4) | Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031083, PubMed:31031084, PubMed:36599982, PubMed:36599985, PubMed:37369656). In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding (PubMed:36599982, PubMed:36599985, PubMed:37369656). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:12403464, PubMed:34352206, PubMed:34352207, PubMed:36599982, PubMed:36599985, PubMed:37369656). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (PubMed:36599982, PubMed:36599985). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084, PubMed:37379838). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069). {ECO:0000269|PubMed:12403464, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:31031083, ECO:0000269|PubMed:31031084, ECO:0000269|PubMed:34352206, ECO:0000269|PubMed:34352207, ECO:0000269|PubMed:36599982, ECO:0000269|PubMed:36599985, ECO:0000269|PubMed:37369656, ECO:0000269|PubMed:37379838}. |
O60563 | CCNT1 | S427 | Sugiyama | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
P31327 | CPS1 | S540 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
O15212 | PFDN6 | S53 | Sugiyama | Prefoldin subunit 6 (Protein Ke2) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
Q14008 | CKAP5 | S1873 | Sugiyama | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
Q99829 | CPNE1 | S130 | Sugiyama | Copine-1 (Chromobindin 17) (Copine I) | Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:19539605, PubMed:9430674). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740). {ECO:0000269|PubMed:12522145, ECO:0000269|PubMed:14674885, ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:19539605, ECO:0000269|PubMed:23263657, ECO:0000269|PubMed:25450385, ECO:0000269|PubMed:9430674}. |
Q96GD4 | AURKB | S61 | Sugiyama | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.000011 | 4.977 |
R-HSA-390522 | Striated Muscle Contraction | 0.000130 | 3.888 |
R-HSA-68877 | Mitotic Prometaphase | 0.000253 | 3.596 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.001256 | 2.901 |
R-HSA-68882 | Mitotic Anaphase | 0.002216 | 2.654 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.002279 | 2.642 |
R-HSA-1640170 | Cell Cycle | 0.001177 | 2.929 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.001845 | 2.734 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.003442 | 2.463 |
R-HSA-68886 | M Phase | 0.003391 | 2.470 |
R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.005284 | 2.277 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.006473 | 2.189 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.005568 | 2.254 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.005568 | 2.254 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.005095 | 2.293 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.006417 | 2.193 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.004208 | 2.376 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.006231 | 2.205 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.006227 | 2.206 |
R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.003838 | 2.416 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.005711 | 2.243 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.007389 | 2.131 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.007389 | 2.131 |
R-HSA-167287 | HIV elongation arrest and recovery | 0.008012 | 2.096 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 0.008012 | 2.096 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.007447 | 2.128 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.010689 | 1.971 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.010587 | 1.975 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.010587 | 1.975 |
R-HSA-373755 | Semaphorin interactions | 0.010587 | 1.975 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.010901 | 1.963 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.012158 | 1.915 |
R-HSA-69275 | G2/M Transition | 0.011801 | 1.928 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.012388 | 1.907 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.014012 | 1.853 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.012678 | 1.897 |
R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.014012 | 1.853 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.013285 | 1.877 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.017904 | 1.747 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.018935 | 1.723 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.018935 | 1.723 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.016385 | 1.786 |
R-HSA-380287 | Centrosome maturation | 0.017742 | 1.751 |
R-HSA-9796292 | Formation of axial mesoderm | 0.017723 | 1.751 |
R-HSA-167169 | HIV Transcription Elongation | 0.018935 | 1.723 |
R-HSA-162587 | HIV Life Cycle | 0.018813 | 1.726 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.015283 | 1.816 |
R-HSA-74160 | Gene expression (Transcription) | 0.018293 | 1.738 |
R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.017723 | 1.751 |
R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.019717 | 1.705 |
R-HSA-9659379 | Sensory processing of sound | 0.020661 | 1.685 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.019847 | 1.702 |
R-HSA-212436 | Generic Transcription Pathway | 0.019787 | 1.704 |
R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.023445 | 1.630 |
R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.023445 | 1.630 |
R-HSA-9673013 | Diseases of Telomere Maintenance | 0.023445 | 1.630 |
R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.023445 | 1.630 |
R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.023445 | 1.630 |
R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.023445 | 1.630 |
R-HSA-9675135 | Diseases of DNA repair | 0.027058 | 1.568 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.027340 | 1.563 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.026226 | 1.581 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.029188 | 1.535 |
R-HSA-199991 | Membrane Trafficking | 0.029302 | 1.533 |
R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.034961 | 1.456 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.033476 | 1.475 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.031109 | 1.507 |
R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.034961 | 1.456 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.035278 | 1.453 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.035278 | 1.453 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.036047 | 1.443 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.036047 | 1.443 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.036047 | 1.443 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.036047 | 1.443 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.036759 | 1.435 |
R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.044195 | 1.355 |
R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 0.046342 | 1.334 |
R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 0.046342 | 1.334 |
R-HSA-9918440 | Defective visual phototransduction due to RDH12 loss of function | 0.046342 | 1.334 |
R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 0.046342 | 1.334 |
R-HSA-429947 | Deadenylation of mRNA | 0.049968 | 1.301 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.052951 | 1.276 |
R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.057590 | 1.240 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.059100 | 1.228 |
R-HSA-397014 | Muscle contraction | 0.059616 | 1.225 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.056038 | 1.252 |
R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.068706 | 1.163 |
R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.079691 | 1.099 |
R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.079691 | 1.099 |
R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.111880 | 0.951 |
R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.111880 | 0.951 |
R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.122359 | 0.912 |
R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.153062 | 0.815 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.182697 | 0.738 |
R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.201879 | 0.695 |
R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.201879 | 0.695 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.119413 | 0.923 |
R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.256777 | 0.590 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.274228 | 0.562 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.274228 | 0.562 |
R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.291272 | 0.536 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.291272 | 0.536 |
R-HSA-1221632 | Meiotic synapsis | 0.163839 | 0.786 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 0.324174 | 0.489 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.340050 | 0.468 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.347849 | 0.459 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.355556 | 0.449 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.355556 | 0.449 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.110170 | 0.958 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.078887 | 1.103 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.078887 | 1.103 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.104508 | 0.981 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.189148 | 0.723 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.358273 | 0.446 |
R-HSA-8939211 | ESR-mediated signaling | 0.087230 | 1.059 |
R-HSA-191650 | Regulation of gap junction activity | 0.068706 | 1.163 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.324174 | 0.489 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.223614 | 0.651 |
R-HSA-5693538 | Homology Directed Repair | 0.207349 | 0.683 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.189275 | 0.723 |
R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.229814 | 0.639 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.147057 | 0.833 |
R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.090548 | 1.043 |
R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.163058 | 0.788 |
R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.192345 | 0.716 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.070688 | 1.151 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.082363 | 1.084 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.316094 | 0.500 |
R-HSA-8949664 | Processing of SMDT1 | 0.182697 | 0.738 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.316094 | 0.500 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.078887 | 1.103 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.316094 | 0.500 |
R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.101277 | 0.994 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.111703 | 0.952 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.085884 | 1.066 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.223614 | 0.651 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.068706 | 1.163 |
R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.090548 | 1.043 |
R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.101277 | 0.994 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.065482 | 1.184 |
R-HSA-162588 | Budding and maturation of HIV virion | 0.072082 | 1.142 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.201879 | 0.695 |
R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.211301 | 0.675 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.085884 | 1.066 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.085884 | 1.066 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.088024 | 1.055 |
R-HSA-1500620 | Meiosis | 0.099680 | 1.001 |
R-HSA-9839394 | TGFBR3 expression | 0.307917 | 0.512 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.189148 | 0.723 |
R-HSA-191859 | snRNP Assembly | 0.189148 | 0.723 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.127318 | 0.895 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.340050 | 0.468 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.362526 | 0.441 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.303442 | 0.518 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.074864 | 1.126 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.289371 | 0.539 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.148938 | 0.827 |
R-HSA-447043 | Neurofascin interactions | 0.101277 | 0.994 |
R-HSA-9620244 | Long-term potentiation | 0.307917 | 0.512 |
R-HSA-5334118 | DNA methylation | 0.340050 | 0.468 |
R-HSA-167172 | Transcription of the HIV genome | 0.062666 | 1.203 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.171641 | 0.765 |
R-HSA-5358508 | Mismatch Repair | 0.238908 | 0.622 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.123316 | 0.909 |
R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.111880 | 0.951 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.100402 | 0.998 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.363172 | 0.440 |
R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.132714 | 0.877 |
R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.072082 | 1.142 |
R-HSA-437239 | Recycling pathway of L1 | 0.139224 | 0.856 |
R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.122359 | 0.912 |
R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 0.122359 | 0.912 |
R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 0.122359 | 0.912 |
R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.163058 | 0.788 |
R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.265554 | 0.576 |
R-HSA-9615710 | Late endosomal microautophagy | 0.340050 | 0.468 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.355556 | 0.449 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.192785 | 0.715 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.173307 | 0.761 |
R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.332159 | 0.479 |
R-HSA-3371556 | Cellular response to heat stress | 0.216529 | 0.664 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.143269 | 0.844 |
R-HSA-8949215 | Mitochondrial calcium ion transport | 0.274228 | 0.562 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.262869 | 0.580 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.119958 | 0.921 |
R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.172936 | 0.762 |
R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.192345 | 0.716 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.078887 | 1.103 |
R-HSA-3371511 | HSF1 activation | 0.093060 | 1.031 |
R-HSA-525793 | Myogenesis | 0.316094 | 0.500 |
R-HSA-73894 | DNA Repair | 0.167572 | 0.776 |
R-HSA-9664417 | Leishmania phagocytosis | 0.117971 | 0.928 |
R-HSA-9664407 | Parasite infection | 0.117971 | 0.928 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.117971 | 0.928 |
R-HSA-373760 | L1CAM interactions | 0.201279 | 0.696 |
R-HSA-447038 | NrCAM interactions | 0.079691 | 1.099 |
R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.111880 | 0.951 |
R-HSA-1462054 | Alpha-defensins | 0.122359 | 0.912 |
R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.172936 | 0.762 |
R-HSA-110320 | Translesion Synthesis by POLH | 0.247895 | 0.606 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.274228 | 0.562 |
R-HSA-1482801 | Acyl chain remodelling of PS | 0.307917 | 0.512 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.137982 | 0.860 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.260948 | 0.583 |
R-HSA-379724 | tRNA Aminoacylation | 0.193419 | 0.714 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.135205 | 0.869 |
R-HSA-9610379 | HCMV Late Events | 0.343913 | 0.464 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.231478 | 0.635 |
R-HSA-9006936 | Signaling by TGFB family members | 0.162552 | 0.789 |
R-HSA-447041 | CHL1 interactions | 0.111880 | 0.951 |
R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.153062 | 0.815 |
R-HSA-399956 | CRMPs in Sema3A signaling | 0.192345 | 0.716 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.265554 | 0.576 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.324174 | 0.489 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.189148 | 0.723 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.324174 | 0.489 |
R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.229814 | 0.639 |
R-HSA-5689603 | UCH proteinases | 0.262889 | 0.580 |
R-HSA-1474165 | Reproduction | 0.250847 | 0.601 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.169758 | 0.770 |
R-HSA-5617833 | Cilium Assembly | 0.104717 | 0.980 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.311648 | 0.506 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.083534 | 1.078 |
R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.316094 | 0.500 |
R-HSA-162906 | HIV Infection | 0.075458 | 1.122 |
R-HSA-9840373 | Cellular response to mitochondrial stress | 0.132714 | 0.877 |
R-HSA-5689877 | Josephin domain DUBs | 0.142948 | 0.845 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.238908 | 0.622 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.197587 | 0.704 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.324174 | 0.489 |
R-HSA-400511 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polyp... | 0.220612 | 0.656 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.096711 | 1.015 |
R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 0.291272 | 0.536 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.340050 | 0.468 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.222696 | 0.652 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.197702 | 0.704 |
R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.163058 | 0.788 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.220612 | 0.656 |
R-HSA-5653656 | Vesicle-mediated transport | 0.069723 | 1.157 |
R-HSA-70171 | Glycolysis | 0.146173 | 0.835 |
R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.111880 | 0.951 |
R-HSA-8851680 | Butyrophilin (BTN) family interactions | 0.132714 | 0.877 |
R-HSA-193144 | Estrogen biosynthesis | 0.172936 | 0.762 |
R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 0.265554 | 0.576 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.316094 | 0.500 |
R-HSA-70635 | Urea cycle | 0.316094 | 0.500 |
R-HSA-9638334 | Iron assimilation using enterobactin | 0.332159 | 0.479 |
R-HSA-9663891 | Selective autophagy | 0.319589 | 0.495 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.135205 | 0.869 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.258514 | 0.588 |
R-HSA-75893 | TNF signaling | 0.176421 | 0.753 |
R-HSA-422475 | Axon guidance | 0.137853 | 0.861 |
R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.153062 | 0.815 |
R-HSA-8876725 | Protein methylation | 0.201879 | 0.695 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.085884 | 1.066 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.324174 | 0.489 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.219274 | 0.659 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.115023 | 0.939 |
R-HSA-9675108 | Nervous system development | 0.105561 | 0.976 |
R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.282800 | 0.549 |
R-HSA-114452 | Activation of BH3-only proteins | 0.347849 | 0.459 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.122359 | 0.912 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.182697 | 0.738 |
R-HSA-9678110 | Attachment and Entry | 0.211301 | 0.675 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.247691 | 0.606 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.073363 | 1.135 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.168750 | 0.773 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.306562 | 0.513 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.220612 | 0.656 |
R-HSA-9694614 | Attachment and Entry | 0.274228 | 0.562 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.299644 | 0.523 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.299644 | 0.523 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.332558 | 0.478 |
R-HSA-5688426 | Deubiquitination | 0.229320 | 0.640 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.339572 | 0.469 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.065662 | 1.183 |
R-HSA-9007101 | Rab regulation of trafficking | 0.204309 | 0.690 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.168750 | 0.773 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.324174 | 0.489 |
R-HSA-1632852 | Macroautophagy | 0.289112 | 0.539 |
R-HSA-2453864 | Retinoid cycle disease events | 0.307917 | 0.512 |
R-HSA-9612973 | Autophagy | 0.340689 | 0.468 |
R-HSA-5218859 | Regulated Necrosis | 0.227961 | 0.642 |
R-HSA-9828806 | Maturation of hRSV A proteins | 0.324174 | 0.489 |
R-HSA-70326 | Glucose metabolism | 0.204309 | 0.690 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.282800 | 0.549 |
R-HSA-9675143 | Diseases of the neuronal system | 0.307917 | 0.512 |
R-HSA-2474795 | Diseases associated with visual transduction | 0.307917 | 0.512 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.347849 | 0.459 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.127250 | 0.895 |
R-HSA-73887 | Death Receptor Signaling | 0.334236 | 0.476 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.210399 | 0.677 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.078887 | 1.103 |
R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.085884 | 1.066 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.291272 | 0.536 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.316094 | 0.500 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.241034 | 0.618 |
R-HSA-5357801 | Programmed Cell Death | 0.131099 | 0.882 |
R-HSA-9909396 | Circadian clock | 0.100760 | 0.997 |
R-HSA-109581 | Apoptosis | 0.360014 | 0.444 |
R-HSA-5620971 | Pyroptosis | 0.332159 | 0.479 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.332159 | 0.479 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.274944 | 0.561 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.122103 | 0.913 |
R-HSA-2028269 | Signaling by Hippo | 0.229814 | 0.639 |
R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.238908 | 0.622 |
R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.282800 | 0.549 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.214942 | 0.668 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.184891 | 0.733 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.363172 | 0.440 |
R-HSA-9020591 | Interleukin-12 signaling | 0.262889 | 0.580 |
R-HSA-447115 | Interleukin-12 family signaling | 0.315253 | 0.501 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.366768 | 0.436 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.370699 | 0.431 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.370699 | 0.431 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.370699 | 0.431 |
R-HSA-9930044 | Nuclear RNA decay | 0.370699 | 0.431 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.370699 | 0.431 |
R-HSA-5675482 | Regulation of necroptotic cell death | 0.370699 | 0.431 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.370999 | 0.431 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.377630 | 0.423 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.378137 | 0.422 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.378137 | 0.422 |
R-HSA-1482788 | Acyl chain remodelling of PC | 0.378137 | 0.422 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.378137 | 0.422 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.378137 | 0.422 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.378137 | 0.422 |
R-HSA-180746 | Nuclear import of Rev protein | 0.385488 | 0.414 |
R-HSA-5205647 | Mitophagy | 0.385488 | 0.414 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.387810 | 0.411 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.387810 | 0.411 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.392753 | 0.406 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.392753 | 0.406 |
R-HSA-1482839 | Acyl chain remodelling of PE | 0.392753 | 0.406 |
R-HSA-2559585 | Oncogene Induced Senescence | 0.392753 | 0.406 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.392753 | 0.406 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.396142 | 0.402 |
R-HSA-9682385 | FLT3 signaling in disease | 0.399931 | 0.398 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.399931 | 0.398 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.399931 | 0.398 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.404725 | 0.393 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.407026 | 0.390 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.407026 | 0.390 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.407026 | 0.390 |
R-HSA-8953897 | Cellular responses to stimuli | 0.410822 | 0.386 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.412647 | 0.384 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.414037 | 0.383 |
R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.414037 | 0.383 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.414037 | 0.383 |
R-HSA-2559583 | Cellular Senescence | 0.420491 | 0.376 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.420966 | 0.376 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.420966 | 0.376 |
R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.420966 | 0.376 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.420966 | 0.376 |
R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.420966 | 0.376 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.420966 | 0.376 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.427813 | 0.369 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.427813 | 0.369 |
R-HSA-3371568 | Attenuation phase | 0.427813 | 0.369 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.427813 | 0.369 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.427813 | 0.369 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.427813 | 0.369 |
R-HSA-9646399 | Aggrephagy | 0.427813 | 0.369 |
R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.427813 | 0.369 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.434579 | 0.362 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.434579 | 0.362 |
R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.434579 | 0.362 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.434579 | 0.362 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.434579 | 0.362 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.434579 | 0.362 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.434579 | 0.362 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.440985 | 0.356 |
R-HSA-3000480 | Scavenging by Class A Receptors | 0.441266 | 0.355 |
R-HSA-6811438 | Intra-Golgi traffic | 0.441266 | 0.355 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.441266 | 0.355 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.444972 | 0.352 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.447874 | 0.349 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.447874 | 0.349 |
R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.447874 | 0.349 |
R-HSA-909733 | Interferon alpha/beta signaling | 0.452900 | 0.344 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.454405 | 0.343 |
R-HSA-1461973 | Defensins | 0.454405 | 0.343 |
R-HSA-8854214 | TBC/RABGAPs | 0.454405 | 0.343 |
R-HSA-1433557 | Signaling by SCF-KIT | 0.454405 | 0.343 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.454662 | 0.342 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.460859 | 0.336 |
R-HSA-69231 | Cyclin D associated events in G1 | 0.460859 | 0.336 |
R-HSA-69236 | G1 Phase | 0.460859 | 0.336 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.460859 | 0.336 |
R-HSA-2262752 | Cellular responses to stress | 0.462215 | 0.335 |
R-HSA-774815 | Nucleosome assembly | 0.467236 | 0.330 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.467236 | 0.330 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.467236 | 0.330 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.467236 | 0.330 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.467236 | 0.330 |
R-HSA-2453902 | The canonical retinoid cycle in rods (twilight vision) | 0.467236 | 0.330 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.473539 | 0.325 |
R-HSA-75153 | Apoptotic execution phase | 0.473539 | 0.325 |
R-HSA-73886 | Chromosome Maintenance | 0.476291 | 0.322 |
R-HSA-9658195 | Leishmania infection | 0.479586 | 0.319 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.479586 | 0.319 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.479768 | 0.319 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.481993 | 0.317 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.485923 | 0.313 |
R-HSA-5620924 | Intraflagellar transport | 0.485923 | 0.313 |
R-HSA-389356 | Co-stimulation by CD28 | 0.485923 | 0.313 |
R-HSA-162909 | Host Interactions of HIV factors | 0.487759 | 0.312 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.487980 | 0.312 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.492005 | 0.308 |
R-HSA-73893 | DNA Damage Bypass | 0.492005 | 0.308 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.492005 | 0.308 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.495317 | 0.305 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.495317 | 0.305 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.495317 | 0.305 |
R-HSA-6798695 | Neutrophil degranulation | 0.501609 | 0.300 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.503957 | 0.298 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 0.503957 | 0.298 |
R-HSA-912446 | Meiotic recombination | 0.503957 | 0.298 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.509827 | 0.293 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.509827 | 0.293 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.509827 | 0.293 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.509827 | 0.293 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.515629 | 0.288 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.515629 | 0.288 |
R-HSA-445355 | Smooth Muscle Contraction | 0.515629 | 0.288 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 0.515629 | 0.288 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.523176 | 0.281 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.524101 | 0.281 |
R-HSA-3214815 | HDACs deacetylate histones | 0.527027 | 0.278 |
R-HSA-9679506 | SARS-CoV Infections | 0.527283 | 0.278 |
R-HSA-193648 | NRAGE signals death through JNK | 0.532626 | 0.274 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.532626 | 0.274 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.532626 | 0.274 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.538159 | 0.269 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.538159 | 0.269 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.542689 | 0.265 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.543627 | 0.265 |
R-HSA-9948299 | Ribosome-associated quality control | 0.549699 | 0.260 |
R-HSA-6807070 | PTEN Regulation | 0.553176 | 0.257 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.553176 | 0.257 |
R-HSA-8873719 | RAB geranylgeranylation | 0.554370 | 0.256 |
R-HSA-983189 | Kinesins | 0.554370 | 0.256 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.554370 | 0.256 |
R-HSA-1227986 | Signaling by ERBB2 | 0.554370 | 0.256 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.559646 | 0.252 |
R-HSA-1266738 | Developmental Biology | 0.563142 | 0.249 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.564861 | 0.248 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.564861 | 0.248 |
R-HSA-9707616 | Heme signaling | 0.564861 | 0.248 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.566896 | 0.246 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.570014 | 0.244 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.580139 | 0.236 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.581453 | 0.235 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.581982 | 0.235 |
R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.585112 | 0.233 |
R-HSA-69242 | S Phase | 0.586905 | 0.231 |
R-HSA-196807 | Nicotinate metabolism | 0.590027 | 0.229 |
R-HSA-9958863 | SLC-mediated transport of amino acids | 0.590027 | 0.229 |
R-HSA-196071 | Metabolism of steroid hormones | 0.590027 | 0.229 |
R-HSA-9758941 | Gastrulation | 0.590172 | 0.229 |
R-HSA-1643685 | Disease | 0.593591 | 0.227 |
R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.594884 | 0.226 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.594884 | 0.226 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.596651 | 0.224 |
R-HSA-1474244 | Extracellular matrix organization | 0.600159 | 0.222 |
R-HSA-204005 | COPII-mediated vesicle transport | 0.604426 | 0.219 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.605879 | 0.218 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.606225 | 0.217 |
R-HSA-9824446 | Viral Infection Pathways | 0.609048 | 0.215 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.609113 | 0.215 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.609113 | 0.215 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.609113 | 0.215 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.609113 | 0.215 |
R-HSA-9638482 | Metal ion assimilation from the host | 0.609113 | 0.215 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.609378 | 0.215 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.613745 | 0.212 |
R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.613745 | 0.212 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.618322 | 0.209 |
R-HSA-4086398 | Ca2+ pathway | 0.618322 | 0.209 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.618322 | 0.209 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.618322 | 0.209 |
R-HSA-72766 | Translation | 0.619696 | 0.208 |
R-HSA-4839726 | Chromatin organization | 0.620242 | 0.207 |
R-HSA-877300 | Interferon gamma signaling | 0.621799 | 0.206 |
R-HSA-9609646 | HCMV Infection | 0.622740 | 0.206 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.622845 | 0.206 |
R-HSA-1236394 | Signaling by ERBB4 | 0.622845 | 0.206 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.627315 | 0.203 |
R-HSA-8852135 | Protein ubiquitination | 0.627315 | 0.203 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.627315 | 0.203 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.631732 | 0.199 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.636097 | 0.196 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.636897 | 0.196 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.640410 | 0.194 |
R-HSA-5619084 | ABC transporter disorders | 0.640410 | 0.194 |
R-HSA-4086400 | PCP/CE pathway | 0.640410 | 0.194 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.640410 | 0.194 |
R-HSA-168249 | Innate Immune System | 0.641896 | 0.193 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.648886 | 0.188 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.648886 | 0.188 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.653048 | 0.185 |
R-HSA-9734767 | Developmental Cell Lineages | 0.654196 | 0.184 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.657162 | 0.182 |
R-HSA-72306 | tRNA processing | 0.657239 | 0.182 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.665244 | 0.177 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.665244 | 0.177 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.665675 | 0.177 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.665675 | 0.177 |
R-HSA-5689880 | Ub-specific processing proteases | 0.665675 | 0.177 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.669214 | 0.174 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.669214 | 0.174 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.671207 | 0.173 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.673137 | 0.172 |
R-HSA-438064 | Post NMDA receptor activation events | 0.680845 | 0.167 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.680845 | 0.167 |
R-HSA-168255 | Influenza Infection | 0.682049 | 0.166 |
R-HSA-156902 | Peptide chain elongation | 0.684630 | 0.165 |
R-HSA-9645723 | Diseases of programmed cell death | 0.684630 | 0.165 |
R-HSA-112310 | Neurotransmitter release cycle | 0.692068 | 0.160 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.695722 | 0.158 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.695722 | 0.158 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.699332 | 0.155 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.702899 | 0.153 |
R-HSA-391251 | Protein folding | 0.702899 | 0.153 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.705379 | 0.152 |
R-HSA-597592 | Post-translational protein modification | 0.709865 | 0.149 |
R-HSA-1474290 | Collagen formation | 0.709909 | 0.149 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.713351 | 0.147 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.713351 | 0.147 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.716753 | 0.145 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.716753 | 0.145 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.720115 | 0.143 |
R-HSA-157579 | Telomere Maintenance | 0.723438 | 0.141 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.724911 | 0.140 |
R-HSA-1280218 | Adaptive Immune System | 0.726055 | 0.139 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.729965 | 0.137 |
R-HSA-192105 | Synthesis of bile acids and bile salts | 0.729965 | 0.137 |
R-HSA-382556 | ABC-family proteins mediated transport | 0.733171 | 0.135 |
R-HSA-2408557 | Selenocysteine synthesis | 0.736339 | 0.133 |
R-HSA-5663205 | Infectious disease | 0.739232 | 0.131 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.739469 | 0.131 |
R-HSA-376176 | Signaling by ROBO receptors | 0.741098 | 0.130 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.741098 | 0.130 |
R-HSA-192823 | Viral mRNA Translation | 0.742563 | 0.129 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.745620 | 0.127 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.751626 | 0.124 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.751626 | 0.124 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.754576 | 0.122 |
R-HSA-211000 | Gene Silencing by RNA | 0.757491 | 0.121 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.760372 | 0.119 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.760372 | 0.119 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.766032 | 0.116 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.766032 | 0.116 |
R-HSA-194068 | Bile acid and bile salt metabolism | 0.766032 | 0.116 |
R-HSA-6803157 | Antimicrobial peptides | 0.768811 | 0.114 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.771558 | 0.113 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.771558 | 0.113 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.771558 | 0.113 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.774273 | 0.111 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.774273 | 0.111 |
R-HSA-418990 | Adherens junctions interactions | 0.775074 | 0.111 |
R-HSA-8951664 | Neddylation | 0.780995 | 0.107 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.782225 | 0.107 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.782225 | 0.107 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.784813 | 0.105 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.787371 | 0.104 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.787371 | 0.104 |
R-HSA-2980736 | Peptide hormone metabolism | 0.789899 | 0.102 |
R-HSA-68875 | Mitotic Prophase | 0.797303 | 0.098 |
R-HSA-8953854 | Metabolism of RNA | 0.800637 | 0.097 |
R-HSA-72312 | rRNA processing | 0.801558 | 0.096 |
R-HSA-168256 | Immune System | 0.810609 | 0.091 |
R-HSA-194138 | Signaling by VEGF | 0.811342 | 0.091 |
R-HSA-69481 | G2/M Checkpoints | 0.815804 | 0.088 |
R-HSA-114608 | Platelet degranulation | 0.815804 | 0.088 |
R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.826503 | 0.083 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.826844 | 0.083 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.828568 | 0.082 |
R-HSA-1474228 | Degradation of the extracellular matrix | 0.828568 | 0.082 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.830608 | 0.081 |
R-HSA-421270 | Cell-cell junction organization | 0.833082 | 0.079 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.840451 | 0.075 |
R-HSA-5358351 | Signaling by Hedgehog | 0.842351 | 0.075 |
R-HSA-162582 | Signal Transduction | 0.852843 | 0.069 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.853284 | 0.069 |
R-HSA-9711123 | Cellular response to chemical stress | 0.857398 | 0.067 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.858464 | 0.066 |
R-HSA-913531 | Interferon Signaling | 0.860050 | 0.065 |
R-HSA-2187338 | Visual phototransduction | 0.860150 | 0.065 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.861816 | 0.065 |
R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.865089 | 0.063 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.865089 | 0.063 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.865089 | 0.063 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.868285 | 0.061 |
R-HSA-446728 | Cell junction organization | 0.870154 | 0.060 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.871405 | 0.060 |
R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.875949 | 0.058 |
R-HSA-9711097 | Cellular response to starvation | 0.877428 | 0.057 |
R-HSA-1483257 | Phospholipid metabolism | 0.889465 | 0.051 |
R-HSA-5619102 | SLC transporter disorders | 0.889971 | 0.051 |
R-HSA-195721 | Signaling by WNT | 0.892585 | 0.049 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.895128 | 0.048 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.898837 | 0.046 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.898837 | 0.046 |
R-HSA-392499 | Metabolism of proteins | 0.902468 | 0.045 |
R-HSA-1500931 | Cell-Cell communication | 0.909655 | 0.041 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.915583 | 0.038 |
R-HSA-8957322 | Metabolism of steroids | 0.916400 | 0.038 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.919479 | 0.036 |
R-HSA-9609690 | HCMV Early Events | 0.923259 | 0.035 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.923276 | 0.035 |
R-HSA-428157 | Sphingolipid metabolism | 0.927737 | 0.033 |
R-HSA-9640148 | Infection with Enterobacteria | 0.929454 | 0.032 |
R-HSA-5683057 | MAPK family signaling cascades | 0.933261 | 0.030 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.937451 | 0.028 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.945045 | 0.025 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.949639 | 0.022 |
R-HSA-15869 | Metabolism of nucleotides | 0.953152 | 0.021 |
R-HSA-157118 | Signaling by NOTCH | 0.955357 | 0.020 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.959916 | 0.018 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.970383 | 0.013 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.972119 | 0.012 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.975294 | 0.011 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.977300 | 0.010 |
R-HSA-112316 | Neuronal System | 0.980681 | 0.008 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.982543 | 0.008 |
R-HSA-449147 | Signaling by Interleukins | 0.983667 | 0.007 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.990047 | 0.004 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.991023 | 0.004 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.992833 | 0.003 |
R-HSA-109582 | Hemostasis | 0.996585 | 0.001 |
R-HSA-382551 | Transport of small molecules | 0.997996 | 0.001 |
R-HSA-9709957 | Sensory Perception | 0.999353 | 0.000 |
R-HSA-388396 | GPCR downstream signalling | 0.999937 | 0.000 |
R-HSA-372790 | Signaling by GPCR | 0.999978 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 0.999990 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
COT |
0.870 | 0.149 | 2 | 0.891 |
CDC7 |
0.866 | 0.175 | 1 | 0.871 |
PIM3 |
0.864 | 0.130 | -3 | 0.829 |
CLK3 |
0.863 | 0.178 | 1 | 0.824 |
RSK2 |
0.862 | 0.156 | -3 | 0.769 |
NDR2 |
0.859 | 0.080 | -3 | 0.839 |
DSTYK |
0.857 | 0.071 | 2 | 0.913 |
PRKD1 |
0.856 | 0.118 | -3 | 0.827 |
CAMK1B |
0.856 | 0.086 | -3 | 0.862 |
IKKB |
0.856 | -0.003 | -2 | 0.724 |
CAMK2G |
0.856 | 0.064 | 2 | 0.853 |
MOS |
0.855 | 0.068 | 1 | 0.863 |
GRK6 |
0.854 | 0.222 | 1 | 0.876 |
RAF1 |
0.854 | 0.002 | 1 | 0.841 |
PIM1 |
0.853 | 0.129 | -3 | 0.777 |
PRPK |
0.853 | -0.112 | -1 | 0.859 |
P90RSK |
0.853 | 0.096 | -3 | 0.772 |
MAPKAPK2 |
0.852 | 0.129 | -3 | 0.726 |
PRKD2 |
0.852 | 0.110 | -3 | 0.776 |
HUNK |
0.851 | 0.052 | 2 | 0.845 |
GRK1 |
0.851 | 0.138 | -2 | 0.717 |
SKMLCK |
0.851 | 0.122 | -2 | 0.805 |
IKKA |
0.850 | 0.089 | -2 | 0.699 |
NDR1 |
0.850 | 0.039 | -3 | 0.835 |
NLK |
0.850 | 0.051 | 1 | 0.816 |
CAMK2B |
0.850 | 0.167 | 2 | 0.822 |
LATS2 |
0.850 | 0.070 | -5 | 0.716 |
MARK4 |
0.850 | 0.075 | 4 | 0.839 |
ULK2 |
0.849 | -0.092 | 2 | 0.821 |
AMPKA1 |
0.849 | 0.093 | -3 | 0.861 |
GCN2 |
0.849 | -0.162 | 2 | 0.848 |
ERK5 |
0.848 | 0.092 | 1 | 0.798 |
TBK1 |
0.848 | -0.077 | 1 | 0.732 |
ATR |
0.848 | 0.013 | 1 | 0.824 |
RSK3 |
0.848 | 0.069 | -3 | 0.768 |
PKN3 |
0.848 | 0.020 | -3 | 0.830 |
NUAK2 |
0.848 | 0.055 | -3 | 0.845 |
PDHK4 |
0.847 | -0.196 | 1 | 0.834 |
BMPR1B |
0.847 | 0.246 | 1 | 0.869 |
MTOR |
0.847 | -0.118 | 1 | 0.766 |
GRK5 |
0.847 | 0.004 | -3 | 0.844 |
CAMK2D |
0.847 | 0.056 | -3 | 0.840 |
MST4 |
0.847 | 0.050 | 2 | 0.889 |
AURC |
0.847 | 0.141 | -2 | 0.663 |
BMPR2 |
0.847 | -0.127 | -2 | 0.823 |
TSSK2 |
0.847 | 0.108 | -5 | 0.803 |
WNK1 |
0.846 | 0.020 | -2 | 0.815 |
IKKE |
0.846 | -0.065 | 1 | 0.733 |
CAMK2A |
0.846 | 0.145 | 2 | 0.840 |
MAPKAPK3 |
0.846 | 0.055 | -3 | 0.783 |
CAMLCK |
0.846 | 0.059 | -2 | 0.824 |
FAM20C |
0.845 | 0.124 | 2 | 0.652 |
PKACG |
0.845 | 0.072 | -2 | 0.733 |
NIK |
0.845 | 0.016 | -3 | 0.882 |
CDKL1 |
0.845 | 0.010 | -3 | 0.791 |
P70S6KB |
0.845 | 0.064 | -3 | 0.797 |
TSSK1 |
0.845 | 0.104 | -3 | 0.882 |
TGFBR1 |
0.844 | 0.165 | -2 | 0.752 |
AMPKA2 |
0.844 | 0.086 | -3 | 0.828 |
RSK4 |
0.844 | 0.133 | -3 | 0.734 |
DAPK2 |
0.844 | 0.074 | -3 | 0.867 |
PKN2 |
0.843 | 0.034 | -3 | 0.843 |
PDHK1 |
0.843 | -0.169 | 1 | 0.818 |
PKCD |
0.843 | 0.069 | 2 | 0.830 |
PKACB |
0.843 | 0.139 | -2 | 0.684 |
SRPK1 |
0.843 | 0.057 | -3 | 0.744 |
TGFBR2 |
0.842 | -0.042 | -2 | 0.742 |
MSK1 |
0.842 | 0.119 | -3 | 0.745 |
PRKX |
0.842 | 0.171 | -3 | 0.686 |
NEK6 |
0.841 | -0.079 | -2 | 0.782 |
PAK1 |
0.841 | 0.073 | -2 | 0.775 |
LATS1 |
0.841 | 0.123 | -3 | 0.853 |
NEK7 |
0.840 | -0.133 | -3 | 0.827 |
CHAK2 |
0.840 | -0.015 | -1 | 0.884 |
ALK4 |
0.839 | 0.098 | -2 | 0.781 |
ULK1 |
0.839 | -0.124 | -3 | 0.819 |
MSK2 |
0.839 | 0.046 | -3 | 0.732 |
RIPK3 |
0.839 | -0.079 | 3 | 0.653 |
PLK1 |
0.839 | 0.064 | -2 | 0.766 |
CDKL5 |
0.839 | 0.005 | -3 | 0.785 |
NIM1 |
0.838 | -0.018 | 3 | 0.736 |
BCKDK |
0.838 | -0.101 | -1 | 0.830 |
CLK2 |
0.838 | 0.162 | -3 | 0.753 |
GRK7 |
0.837 | 0.125 | 1 | 0.811 |
DLK |
0.837 | -0.030 | 1 | 0.835 |
MNK2 |
0.837 | 0.070 | -2 | 0.777 |
HIPK4 |
0.837 | -0.002 | 1 | 0.759 |
ICK |
0.837 | 0.003 | -3 | 0.829 |
ATM |
0.836 | 0.025 | 1 | 0.777 |
MLK1 |
0.836 | -0.116 | 2 | 0.851 |
PAK6 |
0.836 | 0.113 | -2 | 0.729 |
PAK3 |
0.836 | 0.019 | -2 | 0.783 |
QSK |
0.836 | 0.063 | 4 | 0.807 |
AURB |
0.835 | 0.096 | -2 | 0.668 |
ALK2 |
0.835 | 0.145 | -2 | 0.760 |
WNK3 |
0.835 | -0.173 | 1 | 0.790 |
CLK4 |
0.835 | 0.091 | -3 | 0.769 |
GRK4 |
0.835 | -0.073 | -2 | 0.742 |
MARK3 |
0.834 | 0.093 | 4 | 0.787 |
PRKD3 |
0.834 | 0.042 | -3 | 0.751 |
CHK1 |
0.834 | 0.070 | -3 | 0.838 |
KIS |
0.834 | -0.005 | 1 | 0.681 |
CAMK4 |
0.834 | -0.029 | -3 | 0.824 |
SRPK2 |
0.834 | 0.037 | -3 | 0.664 |
NEK9 |
0.833 | -0.116 | 2 | 0.868 |
MASTL |
0.833 | -0.234 | -2 | 0.759 |
MELK |
0.833 | 0.010 | -3 | 0.815 |
MNK1 |
0.832 | 0.071 | -2 | 0.788 |
ACVR2B |
0.832 | 0.118 | -2 | 0.748 |
BMPR1A |
0.832 | 0.202 | 1 | 0.845 |
ACVR2A |
0.832 | 0.100 | -2 | 0.734 |
SIK |
0.832 | 0.036 | -3 | 0.763 |
MYLK4 |
0.832 | 0.068 | -2 | 0.764 |
BRSK1 |
0.832 | 0.039 | -3 | 0.799 |
MARK2 |
0.832 | 0.075 | 4 | 0.749 |
PKR |
0.832 | 0.036 | 1 | 0.809 |
CLK1 |
0.831 | 0.083 | -3 | 0.752 |
CDK8 |
0.831 | -0.006 | 1 | 0.654 |
AURA |
0.831 | 0.088 | -2 | 0.640 |
NUAK1 |
0.831 | -0.003 | -3 | 0.799 |
DNAPK |
0.831 | 0.070 | 1 | 0.703 |
PLK3 |
0.831 | 0.014 | 2 | 0.800 |
PKG2 |
0.830 | 0.069 | -2 | 0.683 |
JNK2 |
0.830 | 0.093 | 1 | 0.621 |
RIPK1 |
0.830 | -0.151 | 1 | 0.782 |
ANKRD3 |
0.830 | -0.151 | 1 | 0.837 |
PKCB |
0.829 | 0.022 | 2 | 0.779 |
JNK3 |
0.829 | 0.075 | 1 | 0.649 |
QIK |
0.829 | -0.040 | -3 | 0.835 |
MLK2 |
0.829 | -0.131 | 2 | 0.853 |
MARK1 |
0.829 | 0.064 | 4 | 0.800 |
DYRK2 |
0.828 | 0.025 | 1 | 0.688 |
PIM2 |
0.828 | 0.058 | -3 | 0.747 |
MEK1 |
0.828 | -0.077 | 2 | 0.866 |
SGK3 |
0.827 | 0.053 | -3 | 0.771 |
PKCG |
0.827 | -0.003 | 2 | 0.785 |
TTBK2 |
0.827 | -0.171 | 2 | 0.745 |
PAK2 |
0.826 | -0.008 | -2 | 0.766 |
AKT2 |
0.826 | 0.058 | -3 | 0.689 |
NEK2 |
0.826 | -0.060 | 2 | 0.845 |
PKCA |
0.825 | 0.007 | 2 | 0.775 |
CDK7 |
0.825 | -0.011 | 1 | 0.666 |
PKACA |
0.825 | 0.097 | -2 | 0.639 |
CDK19 |
0.825 | -0.007 | 1 | 0.616 |
CDK5 |
0.825 | 0.035 | 1 | 0.687 |
MLK3 |
0.824 | -0.073 | 2 | 0.793 |
YSK4 |
0.824 | -0.102 | 1 | 0.769 |
IRE1 |
0.824 | -0.131 | 1 | 0.749 |
CDK1 |
0.824 | 0.029 | 1 | 0.645 |
SSTK |
0.824 | 0.080 | 4 | 0.791 |
CDK13 |
0.824 | 0.000 | 1 | 0.638 |
BRSK2 |
0.824 | -0.037 | -3 | 0.826 |
DCAMKL1 |
0.824 | 0.029 | -3 | 0.797 |
SMG1 |
0.824 | -0.022 | 1 | 0.767 |
SRPK3 |
0.824 | -0.011 | -3 | 0.710 |
PKCH |
0.823 | -0.017 | 2 | 0.768 |
TLK2 |
0.823 | -0.065 | 1 | 0.790 |
DRAK1 |
0.823 | 0.052 | 1 | 0.823 |
CK2A2 |
0.823 | 0.187 | 1 | 0.755 |
VRK2 |
0.823 | -0.203 | 1 | 0.839 |
GRK2 |
0.822 | 0.027 | -2 | 0.644 |
P38A |
0.822 | 0.027 | 1 | 0.697 |
MLK4 |
0.821 | -0.075 | 2 | 0.773 |
P38B |
0.821 | 0.045 | 1 | 0.640 |
PASK |
0.821 | 0.101 | -3 | 0.838 |
IRE2 |
0.821 | -0.111 | 2 | 0.789 |
CDK2 |
0.821 | -0.003 | 1 | 0.733 |
PKCZ |
0.820 | -0.043 | 2 | 0.815 |
CAMK1G |
0.820 | -0.010 | -3 | 0.758 |
BRAF |
0.820 | -0.022 | -4 | 0.821 |
P38G |
0.819 | 0.040 | 1 | 0.555 |
CDK18 |
0.819 | 0.018 | 1 | 0.602 |
CHAK1 |
0.818 | -0.144 | 2 | 0.807 |
GSK3B |
0.818 | 0.079 | 4 | 0.514 |
CDK9 |
0.818 | -0.010 | 1 | 0.644 |
CAMK1D |
0.818 | 0.052 | -3 | 0.692 |
P70S6K |
0.817 | 0.007 | -3 | 0.707 |
HIPK1 |
0.817 | 0.032 | 1 | 0.696 |
PHKG1 |
0.817 | -0.102 | -3 | 0.826 |
MAPKAPK5 |
0.817 | -0.097 | -3 | 0.713 |
HIPK2 |
0.817 | 0.036 | 1 | 0.598 |
GSK3A |
0.817 | 0.097 | 4 | 0.526 |
ERK1 |
0.816 | 0.012 | 1 | 0.621 |
ERK2 |
0.816 | 0.002 | 1 | 0.663 |
AKT1 |
0.816 | 0.062 | -3 | 0.710 |
CDK12 |
0.816 | -0.003 | 1 | 0.614 |
PLK4 |
0.815 | -0.120 | 2 | 0.669 |
SMMLCK |
0.815 | 0.011 | -3 | 0.815 |
CAMKK1 |
0.814 | 0.040 | -2 | 0.776 |
DCAMKL2 |
0.814 | -0.018 | -3 | 0.820 |
DYRK4 |
0.814 | 0.038 | 1 | 0.617 |
MST3 |
0.814 | -0.002 | 2 | 0.872 |
SNRK |
0.814 | -0.182 | 2 | 0.703 |
PERK |
0.813 | -0.173 | -2 | 0.777 |
WNK4 |
0.813 | -0.118 | -2 | 0.803 |
P38D |
0.813 | 0.068 | 1 | 0.551 |
DAPK3 |
0.813 | 0.082 | -3 | 0.799 |
PRP4 |
0.813 | 0.022 | -3 | 0.791 |
CK2A1 |
0.813 | 0.168 | 1 | 0.740 |
MEKK1 |
0.812 | -0.139 | 1 | 0.790 |
DYRK1A |
0.812 | -0.008 | 1 | 0.718 |
CDK3 |
0.812 | 0.029 | 1 | 0.578 |
PAK5 |
0.812 | 0.035 | -2 | 0.658 |
GAK |
0.811 | 0.047 | 1 | 0.818 |
CDK17 |
0.811 | -0.003 | 1 | 0.560 |
PAK4 |
0.811 | 0.051 | -2 | 0.658 |
NEK5 |
0.810 | -0.105 | 1 | 0.800 |
PKCT |
0.810 | -0.033 | 2 | 0.774 |
MEKK3 |
0.810 | -0.186 | 1 | 0.803 |
DYRK1B |
0.810 | 0.012 | 1 | 0.653 |
ZAK |
0.810 | -0.166 | 1 | 0.766 |
PINK1 |
0.809 | -0.178 | 1 | 0.779 |
TAO3 |
0.809 | -0.058 | 1 | 0.791 |
HRI |
0.809 | -0.237 | -2 | 0.785 |
MEK5 |
0.809 | -0.274 | 2 | 0.853 |
TLK1 |
0.809 | -0.154 | -2 | 0.747 |
CAMKK2 |
0.809 | 0.033 | -2 | 0.765 |
MEKK2 |
0.809 | -0.152 | 2 | 0.837 |
PHKG2 |
0.809 | -0.051 | -3 | 0.811 |
CDK14 |
0.809 | 0.012 | 1 | 0.647 |
IRAK4 |
0.809 | -0.112 | 1 | 0.754 |
LKB1 |
0.809 | 0.020 | -3 | 0.841 |
GRK3 |
0.808 | 0.010 | -2 | 0.598 |
CDK16 |
0.808 | 0.030 | 1 | 0.575 |
CDK10 |
0.808 | 0.041 | 1 | 0.630 |
PKCI |
0.808 | -0.016 | 2 | 0.788 |
DYRK3 |
0.807 | 0.021 | 1 | 0.696 |
HIPK3 |
0.807 | -0.021 | 1 | 0.698 |
DAPK1 |
0.807 | 0.076 | -3 | 0.779 |
PLK2 |
0.807 | 0.043 | -3 | 0.782 |
JNK1 |
0.807 | 0.047 | 1 | 0.614 |
MRCKA |
0.804 | 0.054 | -3 | 0.758 |
PKCE |
0.804 | 0.016 | 2 | 0.774 |
ROCK2 |
0.804 | 0.082 | -3 | 0.796 |
MRCKB |
0.804 | 0.059 | -3 | 0.744 |
GCK |
0.803 | 0.005 | 1 | 0.818 |
SGK1 |
0.803 | 0.045 | -3 | 0.605 |
AKT3 |
0.803 | 0.050 | -3 | 0.621 |
NEK8 |
0.802 | -0.153 | 2 | 0.849 |
TAO2 |
0.802 | -0.107 | 2 | 0.881 |
ERK7 |
0.801 | 0.026 | 2 | 0.587 |
CK1E |
0.801 | -0.093 | -3 | 0.512 |
MST2 |
0.801 | -0.064 | 1 | 0.820 |
CAMK1A |
0.800 | 0.025 | -3 | 0.653 |
TTBK1 |
0.800 | -0.174 | 2 | 0.661 |
SBK |
0.800 | 0.039 | -3 | 0.566 |
TAK1 |
0.800 | -0.047 | 1 | 0.815 |
TNIK |
0.800 | -0.027 | 3 | 0.788 |
MPSK1 |
0.800 | -0.090 | 1 | 0.731 |
NEK4 |
0.799 | -0.096 | 1 | 0.771 |
EEF2K |
0.799 | -0.059 | 3 | 0.773 |
MINK |
0.799 | -0.054 | 1 | 0.784 |
IRAK1 |
0.799 | -0.234 | -1 | 0.765 |
CHK2 |
0.799 | -0.002 | -3 | 0.637 |
HGK |
0.798 | -0.064 | 3 | 0.785 |
PKN1 |
0.798 | -0.032 | -3 | 0.728 |
HPK1 |
0.798 | -0.008 | 1 | 0.804 |
MEKK6 |
0.798 | -0.117 | 1 | 0.782 |
PDK1 |
0.798 | -0.131 | 1 | 0.764 |
NEK11 |
0.798 | -0.205 | 1 | 0.787 |
DMPK1 |
0.796 | 0.092 | -3 | 0.761 |
MAK |
0.796 | 0.037 | -2 | 0.662 |
CDK4 |
0.795 | 0.005 | 1 | 0.602 |
NEK1 |
0.795 | -0.071 | 1 | 0.773 |
LOK |
0.795 | -0.070 | -2 | 0.738 |
KHS1 |
0.795 | 0.001 | 1 | 0.778 |
CK1G1 |
0.794 | -0.122 | -3 | 0.510 |
KHS2 |
0.794 | 0.030 | 1 | 0.798 |
LRRK2 |
0.794 | -0.149 | 2 | 0.876 |
MST1 |
0.793 | -0.081 | 1 | 0.794 |
VRK1 |
0.793 | -0.149 | 2 | 0.861 |
CDK6 |
0.793 | -0.005 | 1 | 0.617 |
CK1D |
0.793 | -0.087 | -3 | 0.459 |
BUB1 |
0.792 | 0.039 | -5 | 0.736 |
MAP3K15 |
0.792 | -0.160 | 1 | 0.746 |
CK1A2 |
0.791 | -0.083 | -3 | 0.459 |
PDHK3_TYR |
0.791 | 0.291 | 4 | 0.879 |
PBK |
0.790 | -0.025 | 1 | 0.734 |
PKG1 |
0.790 | 0.007 | -2 | 0.624 |
STK33 |
0.790 | -0.145 | 2 | 0.656 |
SLK |
0.790 | -0.086 | -2 | 0.664 |
ROCK1 |
0.789 | 0.048 | -3 | 0.760 |
CRIK |
0.789 | 0.046 | -3 | 0.700 |
MOK |
0.789 | 0.009 | 1 | 0.711 |
MEK2 |
0.788 | -0.216 | 2 | 0.836 |
YSK1 |
0.787 | -0.102 | 2 | 0.844 |
RIPK2 |
0.782 | -0.274 | 1 | 0.723 |
PDHK4_TYR |
0.779 | 0.106 | 2 | 0.901 |
OSR1 |
0.778 | -0.117 | 2 | 0.828 |
NEK3 |
0.778 | -0.182 | 1 | 0.724 |
BIKE |
0.778 | -0.008 | 1 | 0.685 |
MAP2K6_TYR |
0.778 | 0.049 | -1 | 0.880 |
TTK |
0.777 | -0.103 | -2 | 0.755 |
TESK1_TYR |
0.776 | -0.080 | 3 | 0.821 |
MAP2K4_TYR |
0.776 | -0.045 | -1 | 0.877 |
BMPR2_TYR |
0.774 | 0.039 | -1 | 0.857 |
HASPIN |
0.773 | -0.034 | -1 | 0.756 |
ALPHAK3 |
0.773 | -0.057 | -1 | 0.772 |
MYO3B |
0.773 | -0.091 | 2 | 0.858 |
MAP2K7_TYR |
0.773 | -0.189 | 2 | 0.889 |
YANK3 |
0.772 | -0.072 | 2 | 0.434 |
ASK1 |
0.772 | -0.171 | 1 | 0.731 |
PKMYT1_TYR |
0.771 | -0.136 | 3 | 0.778 |
LIMK2_TYR |
0.770 | -0.047 | -3 | 0.892 |
PDHK1_TYR |
0.769 | -0.076 | -1 | 0.885 |
MYO3A |
0.769 | -0.121 | 1 | 0.764 |
PINK1_TYR |
0.769 | -0.182 | 1 | 0.818 |
EPHA6 |
0.769 | 0.024 | -1 | 0.846 |
TAO1 |
0.765 | -0.158 | 1 | 0.707 |
EPHB4 |
0.764 | -0.020 | -1 | 0.834 |
RET |
0.763 | -0.177 | 1 | 0.788 |
AAK1 |
0.763 | 0.030 | 1 | 0.581 |
DDR1 |
0.762 | -0.114 | 4 | 0.809 |
TXK |
0.760 | 0.079 | 1 | 0.874 |
LIMK1_TYR |
0.760 | -0.234 | 2 | 0.883 |
STLK3 |
0.759 | -0.208 | 1 | 0.745 |
CK1A |
0.759 | -0.084 | -3 | 0.368 |
TYRO3 |
0.759 | -0.164 | 3 | 0.715 |
TYK2 |
0.759 | -0.237 | 1 | 0.785 |
ROS1 |
0.759 | -0.161 | 3 | 0.693 |
FER |
0.758 | -0.091 | 1 | 0.884 |
EPHA4 |
0.758 | -0.011 | 2 | 0.802 |
INSRR |
0.757 | -0.080 | 3 | 0.675 |
EPHB1 |
0.757 | -0.026 | 1 | 0.876 |
MST1R |
0.756 | -0.241 | 3 | 0.714 |
YES1 |
0.756 | -0.093 | -1 | 0.821 |
SRMS |
0.755 | -0.030 | 1 | 0.885 |
JAK2 |
0.755 | -0.235 | 1 | 0.778 |
EPHB3 |
0.754 | -0.054 | -1 | 0.813 |
ABL2 |
0.754 | -0.098 | -1 | 0.800 |
EPHB2 |
0.754 | -0.029 | -1 | 0.808 |
TNK2 |
0.753 | -0.096 | 3 | 0.666 |
CSF1R |
0.753 | -0.191 | 3 | 0.691 |
ITK |
0.753 | -0.046 | -1 | 0.772 |
FGR |
0.753 | -0.161 | 1 | 0.853 |
FGFR2 |
0.751 | -0.172 | 3 | 0.722 |
JAK3 |
0.750 | -0.200 | 1 | 0.763 |
ABL1 |
0.750 | -0.116 | -1 | 0.792 |
TNNI3K_TYR |
0.750 | -0.092 | 1 | 0.771 |
NEK10_TYR |
0.749 | -0.132 | 1 | 0.656 |
AXL |
0.749 | -0.135 | 3 | 0.688 |
TNK1 |
0.749 | -0.130 | 3 | 0.698 |
PDGFRB |
0.749 | -0.204 | 3 | 0.710 |
BMX |
0.748 | -0.035 | -1 | 0.701 |
MERTK |
0.748 | -0.086 | 3 | 0.688 |
HCK |
0.747 | -0.158 | -1 | 0.787 |
DDR2 |
0.747 | -0.039 | 3 | 0.652 |
TEC |
0.747 | -0.064 | -1 | 0.727 |
FGFR1 |
0.746 | -0.204 | 3 | 0.685 |
FLT3 |
0.746 | -0.210 | 3 | 0.706 |
TEK |
0.745 | -0.202 | 3 | 0.664 |
EPHA7 |
0.745 | -0.066 | 2 | 0.804 |
BLK |
0.745 | -0.075 | -1 | 0.795 |
LCK |
0.745 | -0.117 | -1 | 0.786 |
KIT |
0.744 | -0.210 | 3 | 0.698 |
ALK |
0.743 | -0.160 | 3 | 0.632 |
NTRK1 |
0.742 | -0.177 | -1 | 0.821 |
LTK |
0.742 | -0.153 | 3 | 0.647 |
EPHA3 |
0.742 | -0.115 | 2 | 0.779 |
PTK2B |
0.741 | -0.017 | -1 | 0.768 |
JAK1 |
0.741 | -0.176 | 1 | 0.725 |
KDR |
0.741 | -0.224 | 3 | 0.652 |
FYN |
0.741 | -0.060 | -1 | 0.761 |
BTK |
0.740 | -0.204 | -1 | 0.741 |
EPHA5 |
0.740 | -0.047 | 2 | 0.787 |
CK1G3 |
0.739 | -0.108 | -3 | 0.321 |
INSR |
0.739 | -0.165 | 3 | 0.650 |
PTK6 |
0.739 | -0.230 | -1 | 0.713 |
WEE1_TYR |
0.738 | -0.167 | -1 | 0.752 |
MET |
0.738 | -0.205 | 3 | 0.686 |
FGFR3 |
0.737 | -0.197 | 3 | 0.689 |
PDGFRA |
0.737 | -0.313 | 3 | 0.702 |
YANK2 |
0.736 | -0.110 | 2 | 0.451 |
EPHA1 |
0.736 | -0.176 | 3 | 0.663 |
FRK |
0.736 | -0.149 | -1 | 0.806 |
NTRK2 |
0.735 | -0.233 | 3 | 0.658 |
NTRK3 |
0.735 | -0.157 | -1 | 0.772 |
ERBB2 |
0.735 | -0.223 | 1 | 0.771 |
EPHA8 |
0.733 | -0.100 | -1 | 0.782 |
PTK2 |
0.733 | 0.014 | -1 | 0.755 |
FLT1 |
0.733 | -0.213 | -1 | 0.816 |
FLT4 |
0.732 | -0.248 | 3 | 0.659 |
EGFR |
0.732 | -0.099 | 1 | 0.691 |
MATK |
0.732 | -0.160 | -1 | 0.741 |
LYN |
0.730 | -0.181 | 3 | 0.621 |
SRC |
0.729 | -0.133 | -1 | 0.767 |
CSK |
0.729 | -0.174 | 2 | 0.803 |
SYK |
0.729 | -0.027 | -1 | 0.738 |
FGFR4 |
0.727 | -0.145 | -1 | 0.759 |
EPHA2 |
0.725 | -0.096 | -1 | 0.747 |
IGF1R |
0.724 | -0.157 | 3 | 0.599 |
MUSK |
0.721 | -0.167 | 1 | 0.686 |
ERBB4 |
0.718 | -0.098 | 1 | 0.735 |
CK1G2 |
0.718 | -0.126 | -3 | 0.420 |
FES |
0.710 | -0.132 | -1 | 0.683 |
ZAP70 |
0.698 | -0.121 | -1 | 0.676 |