Motif 715 (n=169)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0A6YYG9 ARPC4-TTLL3 S42 ochoa Protein ARPC4-TTLL3 None
A4UGR9 XIRP2 S117 ochoa Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}.
I3L4J1 None S114 ochoa vesicle-fusing ATPase (EC 3.6.4.6) (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000256|ARBA:ARBA00059988}.
M0R2C6 None S196 ochoa serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (Seryl-tRNA(Ser/Sec) synthetase) None
O14744 PRMT5 S335 psp Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}.
O15078 CEP290 S1610 ochoa Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973). {ECO:0000250|UniProtKB:Q6A078, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17705300, ECO:0000269|PubMed:18694559, ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:25552655}.
O15085 ARHGEF11 S213 ochoa Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.
O43823 AKAP8 S644 ochoa A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}.
O60784 TOM1 S355 ochoa Target of Myb1 membrane trafficking protein (Target of Myb protein 1) Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}.
O75469 NR1I2 S208 psp Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}.
O75676 RPS6KA4 S324 psp Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}.
O95394 PGM3 S64 ochoa Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3) Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. {ECO:0000303|PubMed:24589341, ECO:0000303|PubMed:24698316, ECO:0000303|PubMed:24931394}.
P00519 ABL1 S619 ochoa|psp Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.
P03372 ESR1 S46 psp Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}.
P07332 FES S408 ochoa Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}.
P11055 MYH3 S1336 ochoa Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) Muscle contraction.
P12882 MYH1 S1339 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 S1335 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13533 MYH6 S1337 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13535 MYH8 S1338 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P14625 HSP90B1 S514 ochoa Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}.
P16157 ANK1 S1593 ochoa Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}.
P17661 DES S358 ochoa Desmin Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}.
P19484 TFEB S211 psp Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}.
P20810 CAST S311 ochoa Calpastatin (Calpain inhibitor) (Sperm BS-17 component) Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
P22059 OSBP S338 ochoa Oxysterol-binding protein 1 Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}.
P29374 ARID4A S275 ochoa AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}.
P35579 MYH9 S1803 psp Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}.
P35749 MYH11 S1667 ochoa Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) Muscle contraction.
P36897 TGFBR1 S360 ochoa TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis (PubMed:33914044). The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}.
P36955 SERPINF1 S114 psp Pigment epithelium-derived factor (PEDF) (Cell proliferation-inducing gene 35 protein) (EPC-1) (Serpin F1) Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}.
P37059 HSD17B2 S234 ochoa 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}.
P41227 NAA10 S182 ochoa|psp N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}.
P43004 SLC1A2 S521 ochoa Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P43006, ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911}.
P43490 NAMPT S470 ochoa Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.
P46100 ATRX S1253 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46939 UTRN S1795 ochoa Utrophin (Dystrophin-related protein 1) (DRP-1) May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}.
P46939 UTRN S2111 ochoa Utrophin (Dystrophin-related protein 1) (DRP-1) May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}.
P48681 NES S325 ochoa Nestin Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P49321 NASP S610 ochoa Nuclear autoantigenic sperm protein (NASP) Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.
P51956 NEK3 S462 ochoa Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3) Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286, ECO:0000269|PubMed:17297458}.
P52179 MYOM1 S470 ochoa Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P52701 MSH6 S330 ochoa DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}.
P52789 HK2 S122 ochoa Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}.
P55072 VCP S416 ochoa Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}.
P59998 ARPC4 S42 ochoa Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.
P78358 CTAG1A S108 ochoa Cancer/testis antigen 1 (Autoimmunogenic cancer/testis antigen NY-ESO-1) (Cancer/testis antigen 6.1) (CT6.1) (L antigen family member 2) (LAGE-2) None
P78410 BTN3A2 S282 ochoa Butyrophilin subfamily 3 member A2 Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells. {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}.
Q05086 UBE3A S93 ochoa Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990, PubMed:30020076). Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990, PubMed:30020076). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:O08759, ECO:0000269|PubMed:10373495, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:19204938, ECO:0000269|PubMed:19233847, ECO:0000269|PubMed:19325566, ECO:0000269|PubMed:19591933, ECO:0000269|PubMed:22645313, ECO:0000269|PubMed:24273172, ECO:0000269|PubMed:24728990, ECO:0000269|PubMed:30020076}.; FUNCTION: (Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. {ECO:0000269|PubMed:8380895}.
Q07157 TJP1 S878 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q08378 GOLGA3 S385 ochoa Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) Golgi auto-antigen; probably involved in maintaining Golgi structure.
Q08945 SSRP1 S375 ochoa FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}.
Q08AE8 SPIRE1 S169 ochoa Protein spire homolog 1 (Spir-1) Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}.
Q12893 TMEM115 S266 ochoa Transmembrane protein 115 (Placental protein 6) (Protein PL6) May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. {ECO:0000269|PubMed:24806965}.
Q12904 AIMP1 S106 ochoa Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)] Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550). {ECO:0000250|UniProtKB:P31230, ECO:0000269|PubMed:10358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:12237313, ECO:0000269|PubMed:19362550}.
Q12929 EPS8 S775 psp Epidermal growth factor receptor kinase substrate 8 Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}.
Q13568 IRF5 S446 ochoa|psp Interferon regulatory factor 5 (IRF-5) Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}.
Q13625 TP53BP2 S296 ochoa Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Q13772 NCOA4 S186 ochoa Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}.
Q14160 SCRIB S1220 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q15005 SPCS2 S192 ochoa Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). {ECO:0000250|UniProtKB:Q04969, ECO:0000269|PubMed:34388369}.
Q15424 SAFB T194 ochoa Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}.
Q15561 TEAD4 S253 ochoa Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
Q15643 TRIP11 S1341 ochoa Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}.
Q15751 HERC1 S1333 ochoa Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.
Q53GG5 PDLIM3 S89 ochoa PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}.
Q5SR56 MFSD14B S464 ochoa Hippocampus abundant transcript-like protein 1 (Major facilitator superfamily domain-containing 14B) None
Q5T8I3 EEIG2 S313 ochoa EEIG family member 2 (EEIG2) None
Q5T8P6 RBM26 S92 ochoa RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}.
Q5UIP0 RIF1 S1494 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5VT52 RPRD2 S1069 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q5VYS8 TUT7 S939 ochoa Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}.
Q5VZ89 DENND4C S1205 ochoa DENN domain-containing protein 4C Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}.
Q5VZ89 DENND4C S1382 ochoa DENN domain-containing protein 4C Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}.
Q5W0B1 OBI1 S525 ochoa ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}.
Q5XKL5 BTBD8 S876 ochoa BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis) (APache) Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission. {ECO:0000250|UniProtKB:Q80TK0}.
Q6BDS2 BLTP3A S936 ochoa Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}.
Q6DT37 CDC42BPG S480 ochoa Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}.
Q6R327 RICTOR S1177 ochoa|psp Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}.
Q7L2Z9 CENPQ S138 ochoa|psp Centromere protein Q (CENP-Q) Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}.
Q7Z2Z1 TICRR S1583 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z4V5 HDGFL2 S595 ochoa Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}.
Q7Z5J4 RAI1 S846 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q7Z736 PLEKHH3 S30 ochoa Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3) None
Q86UP2 KTN1 S1310 ochoa Kinectin (CG-1 antigen) (Kinesin receptor) Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
Q86UX7 FERMT3 S132 ochoa Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}.
Q86V48 LUZP1 S608 ochoa Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}.
Q86X27 RALGPS2 S23 ochoa Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}.
Q86XD5 FAM131B S105 ochoa Protein FAM131B None
Q86YC2 PALB2 S357 ochoa Partner and localizer of BRCA2 Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}.
Q8IVF2 AHNAK2 S4634 ochoa Protein AHNAK2 None
Q8N201 INTS1 S288 ochoa Integrator complex subunit 1 (Int1) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}.
Q8NCY6 MSANTD4 S286 ochoa Myb/SANT-like DNA-binding domain-containing protein 4 (Myb/SANT-like DNA-binding domain containing 4 with coiled-coils) None
Q8NDI1 EHBP1 S577 ochoa EH domain-binding protein 1 May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}.
Q8NF91 SYNE1 S6268 ochoa Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.
Q8NFA0 USP32 S1422 ochoa Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874). {ECO:0000269|PubMed:36476874}.
Q8WUM0 NUP133 S472 ochoa Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}.
Q8WVT3 TRAPPC12 S78 ochoa Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}.
Q8WZ75 ROBO4 S657 ochoa Roundabout homolog 4 (Magic roundabout) Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}.
Q92878 RAD50 S470 ochoa DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.
Q96CV9 OPTN S170 ochoa Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}.
Q96JM3 CHAMP1 S651 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96L73 NSD1 S571 ochoa Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}.
Q96NR8 RDH12 S174 ochoa Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2) Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448). Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (PubMed:15865448, PubMed:19686838). May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). Has no dehydrogenase activity towards steroids (PubMed:12226107, PubMed:15865448). {ECO:0000269|PubMed:12226107, ECO:0000269|PubMed:15865448, ECO:0000269|PubMed:19686838}.
Q96RG2 PASK S1277 ochoa PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}.
Q96T88 UHRF1 S119 ochoa E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}.
Q99623 PHB2 S119 ochoa Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}.
Q99698 LYST S2152 ochoa Lysosomal-trafficking regulator (Beige homolog) Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}.
Q9BPZ3 PAIP2 S100 ochoa Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2) Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. {ECO:0000269|PubMed:11172725}.
Q9BQF6 SENP7 S436 ochoa Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}.
Q9BRA0 NAA38 S29 ochoa N-alpha-acetyltransferase 38, NatC auxiliary subunit (LSM domain-containing protein 1) (Phosphonoformate immuno-associated protein 2) Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}.
Q9BRP8 PYM1 S177 ochoa Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}.
Q9BRV8 SIKE1 S133 psp Suppressor of IKBKE 1 (Suppressor of IKK-epsilon) Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (PubMed:16281057). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:30622739). {ECO:0000269|PubMed:16281057, ECO:0000269|PubMed:30622739}.
Q9BU19 ZNF692 S146 ochoa Zinc finger protein 692 (AICAR responsive element binding protein) May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. {ECO:0000269|PubMed:17097062, ECO:0000269|PubMed:21910974}.
Q9BWH6 RPAP1 S264 ochoa RNA polymerase II-associated protein 1 Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}.
Q9BWM7 SFXN3 S290 ochoa Sideroflexin-3 Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). {ECO:0000269|PubMed:30442778}.
Q9C0C2 TNKS1BP1 S851 ochoa 182 kDa tankyrase-1-binding protein None
Q9H0A0 NAT10 S957 ochoa RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}.
Q9H246 C1orf21 S93 ochoa Uncharacterized protein C1orf21 (Cell proliferation-inducing gene 13 protein) None
Q9H4E7 DEF6 S387 ochoa Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}.
Q9H981 ACTR8 S412 ochoa Actin-related protein 8 (hArp8) (INO80 complex subunit N) Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.
Q9HB58 SP110 S248 ochoa Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Q9HCE1 MOV10 S973 ochoa Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}.
Q9HD26 GOPC S151 ochoa Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}.
Q9NP74 PALMD S112 ochoa Palmdelphin (Paralemmin-like protein) None
Q9NP81 SARS2 S126 ochoa Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). {ECO:0000250|UniProtKB:Q9N0F3}.
Q9NRA8 EIF4ENIF1 S374 ochoa|psp Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}.
Q9NRF8 CTPS2 S563 ochoa CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2) Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. {ECO:0000269|PubMed:10899599, ECO:0000269|PubMed:16179339}.
Q9NTI5 PDS5B S1257 ochoa Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}.
Q9NUQ6 SPATS2L S116 ochoa SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) None
Q9NYL9 TMOD3 S59 ochoa Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}.
Q9P1Y5 CAMSAP3 S863 ochoa Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.
Q9P206 NHSL3 S93 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P246 STIM2 S343 ochoa Stromal interaction molecule 2 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}.
Q9P253 VPS18 S829 ochoa Vacuolar protein sorting-associated protein 18 homolog (hVPS18) Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). {ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25783203}.
Q9P2G1 ANKIB1 S891 ochoa Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}.
Q9UDT6 CLIP2 S923 ochoa CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Q9UHR4 BAIAP2L1 S317 ochoa BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}.
Q9UKG1 APPL1 S689 ochoa DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}.
Q9UKX2 MYH2 S1341 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UN37 VPS4A S90 ochoa Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization, chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (PubMed:33186545). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Critical for normal erythroblast cytokinesis and correct erythropoiesis (PubMed:33186543). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:15075231, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:33186543, ECO:0000269|PubMed:33186545}.; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:11595185}.
Q9UNE7 STUB1 S137 ochoa E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462, PubMed:26265139). Plays a role in the maintenance of mitochondrial morphology and promotes mitophagic removal of dysfunctional mitochondria; thereby acts as a protector against apoptosis in response to cellular stress (By similarity). Negatively regulates vascular smooth muscle contraction, via degradation of the transcriptional activator MYOCD and subsequent loss of transcription of genes involved in vascular smooth muscle contraction (By similarity). Promotes survival and proliferation of cardiac smooth muscle cells via ubiquitination and degradation of FOXO1, resulting in subsequent repression of FOXO1-mediated transcription of pro-apoptotic genes (PubMed:19483080). Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes (PubMed:20724525). Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3 (PubMed:30980393). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (PubMed:15466472). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (PubMed:10330192, PubMed:11146632, PubMed:15466472). Ubiquitinates CHRNA3 targeting it for endoplasmic reticulum-associated degradation in cortical neurons, as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Ubiquitinates and promotes ESR1 proteasomal degradation in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (PubMed:11557750, PubMed:23990462). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (PubMed:19713937). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (PubMed:28813410). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). Plays a role in the degradation of TP53 (PubMed:26634371). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Ubiquitinates PPARG in macrophages playing a role in M2 macrophages polarization and angiogenesis (By similarity). {ECO:0000250|UniProtKB:A6HD62, ECO:0000250|UniProtKB:Q9WUD1, ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11146632, ECO:0000269|PubMed:11557750, ECO:0000269|PubMed:15466472, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:19567782, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20724525, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24043303, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30980393}.
Q9UP95 SLC12A4 S88 ochoa Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}.
Q9UPN4 CEP131 S525 ochoa Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}.
Q9UPN7 PPP6R1 S530 ochoa Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}.
Q9UPV0 CEP164 S544 ochoa Centrosomal protein of 164 kDa (Cep164) Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}.
Q9UQE7 SMC3 S787 ochoa|psp Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}.
Q9UQN3 CHMP2B S187 ochoa Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2) Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Q9UQR1 ZNF148 S698 ochoa Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Q9Y250 LZTS1 S250 ochoa Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}.
Q9Y2K6 USP20 S263 ochoa Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}.
Q9Y448 KNSTRN S241 ochoa Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1) Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}.
Q9Y4B5 MTCL1 S208 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
Q9Y4J8 DTNA S637 ochoa Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
Q9Y5B9 SUPT16H S899 ochoa FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}.
Q9Y6D9 MAD1L1 S214 psp Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}.
P50454 SERPINH1 S138 Sugiyama Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
P61313 RPL15 S118 Sugiyama Large ribosomal subunit protein eL15 (60S ribosomal protein L15) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
O95881 TXNDC12 S136 Sugiyama Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19) Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity. {ECO:0000269|PubMed:12761212}.
O15075 DCLK1 S160 Sugiyama Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
Q7Z4S6 KIF21A S705 Sugiyama Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}.
P26038 MSN S144 Sugiyama Moesin (Membrane-organizing extension spike protein) Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}.
P57081 WDR4 S128 Sugiyama tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (Protein Wuho homolog) (hWH) (WD repeat-containing protein 4) Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031083, PubMed:31031084, PubMed:36599982, PubMed:36599985, PubMed:37369656). In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding (PubMed:36599982, PubMed:36599985, PubMed:37369656). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:12403464, PubMed:34352206, PubMed:34352207, PubMed:36599982, PubMed:36599985, PubMed:37369656). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (PubMed:36599982, PubMed:36599985). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084, PubMed:37379838). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069). {ECO:0000269|PubMed:12403464, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:31031083, ECO:0000269|PubMed:31031084, ECO:0000269|PubMed:34352206, ECO:0000269|PubMed:34352207, ECO:0000269|PubMed:36599982, ECO:0000269|PubMed:36599985, ECO:0000269|PubMed:37369656, ECO:0000269|PubMed:37379838}.
O60563 CCNT1 S427 Sugiyama Cyclin-T1 (CycT1) (Cyclin-T) Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}.
P31327 CPS1 S540 Sugiyama Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
O15212 PFDN6 S53 Sugiyama Prefoldin subunit 6 (Protein Ke2) Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.
Q14008 CKAP5 S1873 Sugiyama Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}.
Q99829 CPNE1 S130 Sugiyama Copine-1 (Chromobindin 17) (Copine I) Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:19539605, PubMed:9430674). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740). {ECO:0000269|PubMed:12522145, ECO:0000269|PubMed:14674885, ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:19539605, ECO:0000269|PubMed:23263657, ECO:0000269|PubMed:25450385, ECO:0000269|PubMed:9430674}.
Q96GD4 AURKB S61 Sugiyama Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}.
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reactome_id name p -log10_p
R-HSA-383280 Nuclear Receptor transcription pathway 0.000011 4.977
R-HSA-390522 Striated Muscle Contraction 0.000130 3.888
R-HSA-68877 Mitotic Prometaphase 0.000253 3.596
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.001256 2.901
R-HSA-68882 Mitotic Anaphase 0.002216 2.654
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.002279 2.642
R-HSA-1640170 Cell Cycle 0.001177 2.929
R-HSA-69278 Cell Cycle, Mitotic 0.001845 2.734
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.003442 2.463
R-HSA-68886 M Phase 0.003391 2.470
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription 0.005284 2.277
R-HSA-2470946 Cohesin Loading onto Chromatin 0.006473 2.189
R-HSA-141424 Amplification of signal from the kinetochores 0.005568 2.254
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.005568 2.254
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.005095 2.293
R-HSA-2467813 Separation of Sister Chromatids 0.006417 2.193
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.004208 2.376
R-HSA-400685 Sema4D in semaphorin signaling 0.006231 2.205
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.006227 2.206
R-HSA-9819196 Zygotic genome activation (ZGA) 0.003838 2.416
R-HSA-5633007 Regulation of TP53 Activity 0.005711 2.243
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.007389 2.131
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.007389 2.131
R-HSA-167287 HIV elongation arrest and recovery 0.008012 2.096
R-HSA-167290 Pausing and recovery of HIV elongation 0.008012 2.096
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.007447 2.128
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.010689 1.971
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.010587 1.975
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.010587 1.975
R-HSA-373755 Semaphorin interactions 0.010587 1.975
R-HSA-69618 Mitotic Spindle Checkpoint 0.010901 1.963
R-HSA-8854518 AURKA Activation by TPX2 0.012158 1.915
R-HSA-69275 G2/M Transition 0.011801 1.928
R-HSA-453274 Mitotic G2-G2/M phases 0.012388 1.907
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.014012 1.853
R-HSA-162599 Late Phase of HIV Life Cycle 0.012678 1.897
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 0.014012 1.853
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.013285 1.877
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.017904 1.747
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.018935 1.723
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.018935 1.723
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.016385 1.786
R-HSA-380287 Centrosome maturation 0.017742 1.751
R-HSA-9796292 Formation of axial mesoderm 0.017723 1.751
R-HSA-167169 HIV Transcription Elongation 0.018935 1.723
R-HSA-162587 HIV Life Cycle 0.018813 1.726
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.015283 1.816
R-HSA-74160 Gene expression (Transcription) 0.018293 1.738
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 0.017723 1.751
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.019717 1.705
R-HSA-9659379 Sensory processing of sound 0.020661 1.685
R-HSA-73857 RNA Polymerase II Transcription 0.019847 1.702
R-HSA-212436 Generic Transcription Pathway 0.019787 1.704
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.023445 1.630
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.023445 1.630
R-HSA-9673013 Diseases of Telomere Maintenance 0.023445 1.630
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.023445 1.630
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.023445 1.630
R-HSA-5632968 Defective Mismatch Repair Associated With MSH6 0.023445 1.630
R-HSA-9675135 Diseases of DNA repair 0.027058 1.568
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.027340 1.563
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.026226 1.581
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.029188 1.535
R-HSA-199991 Membrane Trafficking 0.029302 1.533
R-HSA-176034 Interactions of Tat with host cellular proteins 0.034961 1.456
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.033476 1.475
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.031109 1.507
R-HSA-5632928 Defective Mismatch Repair Associated With MSH2 0.034961 1.456
R-HSA-112382 Formation of RNA Pol II elongation complex 0.035278 1.453
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.035278 1.453
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.036047 1.443
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.036047 1.443
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.036047 1.443
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.036047 1.443
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.036759 1.435
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.044195 1.355
R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer 0.046342 1.334
R-HSA-3656535 TGFBR1 LBD Mutants in Cancer 0.046342 1.334
R-HSA-9918440 Defective visual phototransduction due to RDH12 loss of function 0.046342 1.334
R-HSA-3642278 Loss of Function of TGFBR2 in Cancer 0.046342 1.334
R-HSA-429947 Deadenylation of mRNA 0.049968 1.301
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.052951 1.276
R-HSA-5423599 Diseases of Mismatch Repair (MMR) 0.057590 1.240
R-HSA-3928663 EPHA-mediated growth cone collapse 0.059100 1.228
R-HSA-397014 Muscle contraction 0.059616 1.225
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.056038 1.252
R-HSA-3656532 TGFBR1 KD Mutants in Cancer 0.068706 1.163
R-HSA-3656534 Loss of Function of TGFBR1 in Cancer 0.079691 1.099
R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer 0.079691 1.099
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 0.111880 0.951
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.111880 0.951
R-HSA-9768778 Regulation of NPAS4 mRNA translation 0.122359 0.912
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 0.153062 0.815
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.182697 0.738
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 0.201879 0.695
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.201879 0.695
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.119413 0.923
R-HSA-9909620 Regulation of PD-L1(CD274) translation 0.256777 0.590
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.274228 0.562
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.274228 0.562
R-HSA-8943723 Regulation of PTEN mRNA translation 0.291272 0.536
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.291272 0.536
R-HSA-1221632 Meiotic synapsis 0.163839 0.786
R-HSA-445095 Interaction between L1 and Ankyrins 0.324174 0.489
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.340050 0.468
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.347849 0.459
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.355556 0.449
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.355556 0.449
R-HSA-9018519 Estrogen-dependent gene expression 0.110170 0.958
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.078887 1.103
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.078887 1.103
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.104508 0.981
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.189148 0.723
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.358273 0.446
R-HSA-8939211 ESR-mediated signaling 0.087230 1.059
R-HSA-191650 Regulation of gap junction activity 0.068706 1.163
R-HSA-73863 RNA Polymerase I Transcription Termination 0.324174 0.489
R-HSA-5693606 DNA Double Strand Break Response 0.223614 0.651
R-HSA-5693538 Homology Directed Repair 0.207349 0.683
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.189275 0.723
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.229814 0.639
R-HSA-5693532 DNA Double-Strand Break Repair 0.147057 0.833
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 0.090548 1.043
R-HSA-5693548 Sensing of DNA Double Strand Breaks 0.163058 0.788
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.192345 0.716
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.070688 1.151
R-HSA-5693537 Resolution of D-Loop Structures 0.082363 1.084
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.316094 0.500
R-HSA-8949664 Processing of SMDT1 0.182697 0.738
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.316094 0.500
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.078887 1.103
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.316094 0.500
R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer 0.101277 0.994
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.111703 0.952
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.085884 1.066
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.223614 0.651
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.068706 1.163
R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer 0.090548 1.043
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 0.101277 0.994
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.065482 1.184
R-HSA-162588 Budding and maturation of HIV virion 0.072082 1.142
R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.201879 0.695
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.211301 0.675
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.085884 1.066
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.085884 1.066
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.088024 1.055
R-HSA-1500620 Meiosis 0.099680 1.001
R-HSA-9839394 TGFBR3 expression 0.307917 0.512
R-HSA-194441 Metabolism of non-coding RNA 0.189148 0.723
R-HSA-191859 snRNP Assembly 0.189148 0.723
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.127318 0.895
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.340050 0.468
R-HSA-6807878 COPI-mediated anterograde transport 0.362526 0.441
R-HSA-9006931 Signaling by Nuclear Receptors 0.303442 0.518
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.074864 1.126
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.289371 0.539
R-HSA-9009391 Extra-nuclear estrogen signaling 0.148938 0.827
R-HSA-447043 Neurofascin interactions 0.101277 0.994
R-HSA-9620244 Long-term potentiation 0.307917 0.512
R-HSA-5334118 DNA methylation 0.340050 0.468
R-HSA-167172 Transcription of the HIV genome 0.062666 1.203
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.171641 0.765
R-HSA-5358508 Mismatch Repair 0.238908 0.622
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.123316 0.909
R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.111880 0.951
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.100402 0.998
R-HSA-9675126 Diseases of mitotic cell cycle 0.363172 0.440
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 0.132714 0.877
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.072082 1.142
R-HSA-437239 Recycling pathway of L1 0.139224 0.856
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 0.122359 0.912
R-HSA-112313 Neurotransmitter uptake and metabolism In glial cells 0.122359 0.912
R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 0.122359 0.912
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 0.163058 0.788
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.265554 0.576
R-HSA-9615710 Late endosomal microautophagy 0.340050 0.468
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.355556 0.449
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.192785 0.715
R-HSA-1257604 PIP3 activates AKT signaling 0.173307 0.761
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.332159 0.479
R-HSA-3371556 Cellular response to heat stress 0.216529 0.664
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.143269 0.844
R-HSA-8949215 Mitochondrial calcium ion transport 0.274228 0.562
R-HSA-389948 Co-inhibition by PD-1 0.262869 0.580
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.119958 0.921
R-HSA-1679131 Trafficking and processing of endosomal TLR 0.172936 0.762
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.192345 0.716
R-HSA-9022692 Regulation of MECP2 expression and activity 0.078887 1.103
R-HSA-3371511 HSF1 activation 0.093060 1.031
R-HSA-525793 Myogenesis 0.316094 0.500
R-HSA-73894 DNA Repair 0.167572 0.776
R-HSA-9664417 Leishmania phagocytosis 0.117971 0.928
R-HSA-9664407 Parasite infection 0.117971 0.928
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.117971 0.928
R-HSA-373760 L1CAM interactions 0.201279 0.696
R-HSA-447038 NrCAM interactions 0.079691 1.099
R-HSA-426117 Cation-coupled Chloride cotransporters 0.111880 0.951
R-HSA-1462054 Alpha-defensins 0.122359 0.912
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 0.172936 0.762
R-HSA-110320 Translesion Synthesis by POLH 0.247895 0.606
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.274228 0.562
R-HSA-1482801 Acyl chain remodelling of PS 0.307917 0.512
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.137982 0.860
R-HSA-9006925 Intracellular signaling by second messengers 0.260948 0.583
R-HSA-379724 tRNA Aminoacylation 0.193419 0.714
R-HSA-9839373 Signaling by TGFBR3 0.135205 0.869
R-HSA-9610379 HCMV Late Events 0.343913 0.464
R-HSA-388841 Regulation of T cell activation by CD28 family 0.231478 0.635
R-HSA-9006936 Signaling by TGFB family members 0.162552 0.789
R-HSA-447041 CHL1 interactions 0.111880 0.951
R-HSA-9754560 SARS-CoV-2 modulates autophagy 0.153062 0.815
R-HSA-399956 CRMPs in Sema3A signaling 0.192345 0.716
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.265554 0.576
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.324174 0.489
R-HSA-429914 Deadenylation-dependent mRNA decay 0.189148 0.723
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.324174 0.489
R-HSA-9768759 Regulation of NPAS4 gene expression 0.229814 0.639
R-HSA-5689603 UCH proteinases 0.262889 0.580
R-HSA-1474165 Reproduction 0.250847 0.601
R-HSA-8878171 Transcriptional regulation by RUNX1 0.169758 0.770
R-HSA-5617833 Cilium Assembly 0.104717 0.980
R-HSA-199977 ER to Golgi Anterograde Transport 0.311648 0.506
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.083534 1.078
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.316094 0.500
R-HSA-162906 HIV Infection 0.075458 1.122
R-HSA-9840373 Cellular response to mitochondrial stress 0.132714 0.877
R-HSA-5689877 Josephin domain DUBs 0.142948 0.845
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.238908 0.622
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.197587 0.704
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.324174 0.489
R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polyp... 0.220612 0.656
R-HSA-5689896 Ovarian tumor domain proteases 0.096711 1.015
R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 0.291272 0.536
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.340050 0.468
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.222696 0.652
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.197702 0.704
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 0.163058 0.788
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 0.220612 0.656
R-HSA-5653656 Vesicle-mediated transport 0.069723 1.157
R-HSA-70171 Glycolysis 0.146173 0.835
R-HSA-9839389 TGFBR3 regulates TGF-beta signaling 0.111880 0.951
R-HSA-8851680 Butyrophilin (BTN) family interactions 0.132714 0.877
R-HSA-193144 Estrogen biosynthesis 0.172936 0.762
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin 0.265554 0.576
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.316094 0.500
R-HSA-70635 Urea cycle 0.316094 0.500
R-HSA-9638334 Iron assimilation using enterobactin 0.332159 0.479
R-HSA-9663891 Selective autophagy 0.319589 0.495
R-HSA-5357905 Regulation of TNFR1 signaling 0.135205 0.869
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.258514 0.588
R-HSA-75893 TNF signaling 0.176421 0.753
R-HSA-422475 Axon guidance 0.137853 0.861
R-HSA-9662834 CD163 mediating an anti-inflammatory response 0.153062 0.815
R-HSA-8876725 Protein methylation 0.201879 0.695
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.085884 1.066
R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.324174 0.489
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.219274 0.659
R-HSA-69620 Cell Cycle Checkpoints 0.115023 0.939
R-HSA-9675108 Nervous system development 0.105561 0.976
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 0.282800 0.549
R-HSA-114452 Activation of BH3-only proteins 0.347849 0.459
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.122359 0.912
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.182697 0.738
R-HSA-9678110 Attachment and Entry 0.211301 0.675
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.247691 0.606
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.073363 1.135
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.168750 0.773
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.306562 0.513
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.220612 0.656
R-HSA-9694614 Attachment and Entry 0.274228 0.562
R-HSA-8863678 Neurodegenerative Diseases 0.299644 0.523
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.299644 0.523
R-HSA-8986944 Transcriptional Regulation by MECP2 0.332558 0.478
R-HSA-5688426 Deubiquitination 0.229320 0.640
R-HSA-9705683 SARS-CoV-2-host interactions 0.339572 0.469
R-HSA-3700989 Transcriptional Regulation by TP53 0.065662 1.183
R-HSA-9007101 Rab regulation of trafficking 0.204309 0.690
R-HSA-9700206 Signaling by ALK in cancer 0.168750 0.773
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.324174 0.489
R-HSA-1632852 Macroautophagy 0.289112 0.539
R-HSA-2453864 Retinoid cycle disease events 0.307917 0.512
R-HSA-9612973 Autophagy 0.340689 0.468
R-HSA-5218859 Regulated Necrosis 0.227961 0.642
R-HSA-9828806 Maturation of hRSV A proteins 0.324174 0.489
R-HSA-70326 Glucose metabolism 0.204309 0.690
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.282800 0.549
R-HSA-9675143 Diseases of the neuronal system 0.307917 0.512
R-HSA-2474795 Diseases associated with visual transduction 0.307917 0.512
R-HSA-8863795 Downregulation of ERBB2 signaling 0.347849 0.459
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.127250 0.895
R-HSA-73887 Death Receptor Signaling 0.334236 0.476
R-HSA-8878166 Transcriptional regulation by RUNX2 0.210399 0.677
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.078887 1.103
R-HSA-9768919 NPAS4 regulates expression of target genes 0.085884 1.066
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.291272 0.536
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.316094 0.500
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.241034 0.618
R-HSA-5357801 Programmed Cell Death 0.131099 0.882
R-HSA-9909396 Circadian clock 0.100760 0.997
R-HSA-109581 Apoptosis 0.360014 0.444
R-HSA-5620971 Pyroptosis 0.332159 0.479
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.332159 0.479
R-HSA-9694516 SARS-CoV-2 Infection 0.274944 0.561
R-HSA-2682334 EPH-Ephrin signaling 0.122103 0.913
R-HSA-2028269 Signaling by Hippo 0.229814 0.639
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 0.238908 0.622
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 0.282800 0.549
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.214942 0.668
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.184891 0.733
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.363172 0.440
R-HSA-9020591 Interleukin-12 signaling 0.262889 0.580
R-HSA-447115 Interleukin-12 family signaling 0.315253 0.501
R-HSA-8878159 Transcriptional regulation by RUNX3 0.366768 0.436
R-HSA-1855170 IPs transport between nucleus and cytosol 0.370699 0.431
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.370699 0.431
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.370699 0.431
R-HSA-9930044 Nuclear RNA decay 0.370699 0.431
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.370699 0.431
R-HSA-5675482 Regulation of necroptotic cell death 0.370699 0.431
R-HSA-8957275 Post-translational protein phosphorylation 0.370999 0.431
R-HSA-1852241 Organelle biogenesis and maintenance 0.377630 0.423
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.378137 0.422
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.378137 0.422
R-HSA-1482788 Acyl chain remodelling of PC 0.378137 0.422
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.378137 0.422
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.378137 0.422
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.378137 0.422
R-HSA-180746 Nuclear import of Rev protein 0.385488 0.414
R-HSA-5205647 Mitophagy 0.385488 0.414
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.387810 0.411
R-HSA-2559580 Oxidative Stress Induced Senescence 0.387810 0.411
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.392753 0.406
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.392753 0.406
R-HSA-1482839 Acyl chain remodelling of PE 0.392753 0.406
R-HSA-2559585 Oncogene Induced Senescence 0.392753 0.406
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.392753 0.406
R-HSA-9860931 Response of endothelial cells to shear stress 0.396142 0.402
R-HSA-9682385 FLT3 signaling in disease 0.399931 0.398
R-HSA-6804757 Regulation of TP53 Degradation 0.399931 0.398
R-HSA-8941326 RUNX2 regulates bone development 0.399931 0.398
R-HSA-9678108 SARS-CoV-1 Infection 0.404725 0.393
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.407026 0.390
R-HSA-933541 TRAF6 mediated IRF7 activation 0.407026 0.390
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.407026 0.390
R-HSA-8953897 Cellular responses to stimuli 0.410822 0.386
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.412647 0.384
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.414037 0.383
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.414037 0.383
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.414037 0.383
R-HSA-2559583 Cellular Senescence 0.420491 0.376
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.420966 0.376
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.420966 0.376
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.420966 0.376
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.420966 0.376
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 0.420966 0.376
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.420966 0.376
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.427813 0.369
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.427813 0.369
R-HSA-3371568 Attenuation phase 0.427813 0.369
R-HSA-177243 Interactions of Rev with host cellular proteins 0.427813 0.369
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.427813 0.369
R-HSA-1251985 Nuclear signaling by ERBB4 0.427813 0.369
R-HSA-9646399 Aggrephagy 0.427813 0.369
R-HSA-379726 Mitochondrial tRNA aminoacylation 0.427813 0.369
R-HSA-5362768 Hh mutants are degraded by ERAD 0.434579 0.362
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.434579 0.362
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 0.434579 0.362
R-HSA-8853884 Transcriptional Regulation by VENTX 0.434579 0.362
R-HSA-3214841 PKMTs methylate histone lysines 0.434579 0.362
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.434579 0.362
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.434579 0.362
R-HSA-9855142 Cellular responses to mechanical stimuli 0.440985 0.356
R-HSA-3000480 Scavenging by Class A Receptors 0.441266 0.355
R-HSA-6811438 Intra-Golgi traffic 0.441266 0.355
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.441266 0.355
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.444972 0.352
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.447874 0.349
R-HSA-379716 Cytosolic tRNA aminoacylation 0.447874 0.349
R-HSA-400508 Incretin synthesis, secretion, and inactivation 0.447874 0.349
R-HSA-909733 Interferon alpha/beta signaling 0.452900 0.344
R-HSA-5387390 Hh mutants abrogate ligand secretion 0.454405 0.343
R-HSA-1461973 Defensins 0.454405 0.343
R-HSA-8854214 TBC/RABGAPs 0.454405 0.343
R-HSA-1433557 Signaling by SCF-KIT 0.454405 0.343
R-HSA-168898 Toll-like Receptor Cascades 0.454662 0.342
R-HSA-3214858 RMTs methylate histone arginines 0.460859 0.336
R-HSA-69231 Cyclin D associated events in G1 0.460859 0.336
R-HSA-69236 G1 Phase 0.460859 0.336
R-HSA-3928662 EPHB-mediated forward signaling 0.460859 0.336
R-HSA-2262752 Cellular responses to stress 0.462215 0.335
R-HSA-774815 Nucleosome assembly 0.467236 0.330
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.467236 0.330
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.467236 0.330
R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.467236 0.330
R-HSA-4608870 Asymmetric localization of PCP proteins 0.467236 0.330
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision) 0.467236 0.330
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.473539 0.325
R-HSA-75153 Apoptotic execution phase 0.473539 0.325
R-HSA-73886 Chromosome Maintenance 0.476291 0.322
R-HSA-9658195 Leishmania infection 0.479586 0.319
R-HSA-9824443 Parasitic Infection Pathways 0.479586 0.319
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.479768 0.319
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.481993 0.317
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.485923 0.313
R-HSA-5620924 Intraflagellar transport 0.485923 0.313
R-HSA-389356 Co-stimulation by CD28 0.485923 0.313
R-HSA-162909 Host Interactions of HIV factors 0.487759 0.312
R-HSA-948021 Transport to the Golgi and subsequent modification 0.487980 0.312
R-HSA-157858 Gap junction trafficking and regulation 0.492005 0.308
R-HSA-73893 DNA Damage Bypass 0.492005 0.308
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.492005 0.308
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.495317 0.305
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.495317 0.305
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.495317 0.305
R-HSA-6798695 Neutrophil degranulation 0.501609 0.300
R-HSA-3371571 HSF1-dependent transactivation 0.503957 0.298
R-HSA-5358346 Hedgehog ligand biogenesis 0.503957 0.298
R-HSA-912446 Meiotic recombination 0.503957 0.298
R-HSA-73772 RNA Polymerase I Promoter Escape 0.509827 0.293
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.509827 0.293
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.509827 0.293
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.509827 0.293
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.515629 0.288
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.515629 0.288
R-HSA-445355 Smooth Muscle Contraction 0.515629 0.288
R-HSA-8948751 Regulation of PTEN stability and activity 0.515629 0.288
R-HSA-9730414 MITF-M-regulated melanocyte development 0.523176 0.281
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.524101 0.281
R-HSA-3214815 HDACs deacetylate histones 0.527027 0.278
R-HSA-9679506 SARS-CoV Infections 0.527283 0.278
R-HSA-193648 NRAGE signals death through JNK 0.532626 0.274
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.532626 0.274
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.532626 0.274
R-HSA-2980766 Nuclear Envelope Breakdown 0.538159 0.269
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.538159 0.269
R-HSA-3858494 Beta-catenin independent WNT signaling 0.542689 0.265
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.543627 0.265
R-HSA-9948299 Ribosome-associated quality control 0.549699 0.260
R-HSA-6807070 PTEN Regulation 0.553176 0.257
R-HSA-381119 Unfolded Protein Response (UPR) 0.553176 0.257
R-HSA-8873719 RAB geranylgeranylation 0.554370 0.256
R-HSA-983189 Kinesins 0.554370 0.256
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.554370 0.256
R-HSA-1227986 Signaling by ERBB2 0.554370 0.256
R-HSA-168325 Viral Messenger RNA Synthesis 0.559646 0.252
R-HSA-1266738 Developmental Biology 0.563142 0.249
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.564861 0.248
R-HSA-6784531 tRNA processing in the nucleus 0.564861 0.248
R-HSA-9707616 Heme signaling 0.564861 0.248
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.566896 0.246
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.570014 0.244
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.580139 0.236
R-HSA-3247509 Chromatin modifying enzymes 0.581453 0.235
R-HSA-212165 Epigenetic regulation of gene expression 0.581982 0.235
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.585112 0.233
R-HSA-69242 S Phase 0.586905 0.231
R-HSA-196807 Nicotinate metabolism 0.590027 0.229
R-HSA-9958863 SLC-mediated transport of amino acids 0.590027 0.229
R-HSA-196071 Metabolism of steroid hormones 0.590027 0.229
R-HSA-9758941 Gastrulation 0.590172 0.229
R-HSA-1643685 Disease 0.593591 0.227
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.594884 0.226
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.594884 0.226
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.596651 0.224
R-HSA-1474244 Extracellular matrix organization 0.600159 0.222
R-HSA-204005 COPII-mediated vesicle transport 0.604426 0.219
R-HSA-446203 Asparagine N-linked glycosylation 0.605879 0.218
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.606225 0.217
R-HSA-9824446 Viral Infection Pathways 0.609048 0.215
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.609113 0.215
R-HSA-427413 NoRC negatively regulates rRNA expression 0.609113 0.215
R-HSA-453276 Regulation of mitotic cell cycle 0.609113 0.215
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.609113 0.215
R-HSA-9638482 Metal ion assimilation from the host 0.609113 0.215
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.609378 0.215
R-HSA-5578749 Transcriptional regulation by small RNAs 0.613745 0.212
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 0.613745 0.212
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.618322 0.209
R-HSA-4086398 Ca2+ pathway 0.618322 0.209
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.618322 0.209
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.618322 0.209
R-HSA-72766 Translation 0.619696 0.208
R-HSA-4839726 Chromatin organization 0.620242 0.207
R-HSA-877300 Interferon gamma signaling 0.621799 0.206
R-HSA-9609646 HCMV Infection 0.622740 0.206
R-HSA-69473 G2/M DNA damage checkpoint 0.622845 0.206
R-HSA-1236394 Signaling by ERBB4 0.622845 0.206
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.627315 0.203
R-HSA-8852135 Protein ubiquitination 0.627315 0.203
R-HSA-1169408 ISG15 antiviral mechanism 0.627315 0.203
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.631732 0.199
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.636097 0.196
R-HSA-2408522 Selenoamino acid metabolism 0.636897 0.196
R-HSA-73864 RNA Polymerase I Transcription 0.640410 0.194
R-HSA-5619084 ABC transporter disorders 0.640410 0.194
R-HSA-4086400 PCP/CE pathway 0.640410 0.194
R-HSA-416482 G alpha (12/13) signalling events 0.640410 0.194
R-HSA-168249 Innate Immune System 0.641896 0.193
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.648886 0.188
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.648886 0.188
R-HSA-5693607 Processing of DNA double-strand break ends 0.653048 0.185
R-HSA-9734767 Developmental Cell Lineages 0.654196 0.184
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.657162 0.182
R-HSA-72306 tRNA processing 0.657239 0.182
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.665244 0.177
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.665244 0.177
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.665675 0.177
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.665675 0.177
R-HSA-5689880 Ub-specific processing proteases 0.665675 0.177
R-HSA-6802957 Oncogenic MAPK signaling 0.669214 0.174
R-HSA-5687128 MAPK6/MAPK4 signaling 0.669214 0.174
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.671207 0.173
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.673137 0.172
R-HSA-438064 Post NMDA receptor activation events 0.680845 0.167
R-HSA-390466 Chaperonin-mediated protein folding 0.680845 0.167
R-HSA-168255 Influenza Infection 0.682049 0.166
R-HSA-156902 Peptide chain elongation 0.684630 0.165
R-HSA-9645723 Diseases of programmed cell death 0.684630 0.165
R-HSA-112310 Neurotransmitter release cycle 0.692068 0.160
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.695722 0.158
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.695722 0.158
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.699332 0.155
R-HSA-156842 Eukaryotic Translation Elongation 0.702899 0.153
R-HSA-391251 Protein folding 0.702899 0.153
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.705379 0.152
R-HSA-597592 Post-translational protein modification 0.709865 0.149
R-HSA-1474290 Collagen formation 0.709909 0.149
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.713351 0.147
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.713351 0.147
R-HSA-72764 Eukaryotic Translation Termination 0.716753 0.145
R-HSA-72689 Formation of a pool of free 40S subunits 0.716753 0.145
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.720115 0.143
R-HSA-157579 Telomere Maintenance 0.723438 0.141
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.724911 0.140
R-HSA-1280218 Adaptive Immune System 0.726055 0.139
R-HSA-193704 p75 NTR receptor-mediated signalling 0.729965 0.137
R-HSA-192105 Synthesis of bile acids and bile salts 0.729965 0.137
R-HSA-382556 ABC-family proteins mediated transport 0.733171 0.135
R-HSA-2408557 Selenocysteine synthesis 0.736339 0.133
R-HSA-5663205 Infectious disease 0.739232 0.131
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.739469 0.131
R-HSA-376176 Signaling by ROBO receptors 0.741098 0.130
R-HSA-1483206 Glycerophospholipid biosynthesis 0.741098 0.130
R-HSA-192823 Viral mRNA Translation 0.742563 0.129
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.745620 0.127
R-HSA-5696398 Nucleotide Excision Repair 0.751626 0.124
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.751626 0.124
R-HSA-9692914 SARS-CoV-1-host interactions 0.754576 0.122
R-HSA-211000 Gene Silencing by RNA 0.757491 0.121
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.760372 0.119
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.760372 0.119
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.766032 0.116
R-HSA-166166 MyD88-independent TLR4 cascade 0.766032 0.116
R-HSA-194068 Bile acid and bile salt metabolism 0.766032 0.116
R-HSA-6803157 Antimicrobial peptides 0.768811 0.114
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.771558 0.113
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.771558 0.113
R-HSA-1483249 Inositol phosphate metabolism 0.771558 0.113
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.774273 0.111
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.774273 0.111
R-HSA-418990 Adherens junctions interactions 0.775074 0.111
R-HSA-8951664 Neddylation 0.780995 0.107
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.782225 0.107
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.782225 0.107
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.784813 0.105
R-HSA-72613 Eukaryotic Translation Initiation 0.787371 0.104
R-HSA-72737 Cap-dependent Translation Initiation 0.787371 0.104
R-HSA-2980736 Peptide hormone metabolism 0.789899 0.102
R-HSA-68875 Mitotic Prophase 0.797303 0.098
R-HSA-8953854 Metabolism of RNA 0.800637 0.097
R-HSA-72312 rRNA processing 0.801558 0.096
R-HSA-168256 Immune System 0.810609 0.091
R-HSA-194138 Signaling by VEGF 0.811342 0.091
R-HSA-69481 G2/M Checkpoints 0.815804 0.088
R-HSA-114608 Platelet degranulation 0.815804 0.088
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 0.826503 0.083
R-HSA-5619115 Disorders of transmembrane transporters 0.826844 0.083
R-HSA-8856688 Golgi-to-ER retrograde transport 0.828568 0.082
R-HSA-1474228 Degradation of the extracellular matrix 0.828568 0.082
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.830608 0.081
R-HSA-421270 Cell-cell junction organization 0.833082 0.079
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.840451 0.075
R-HSA-5358351 Signaling by Hedgehog 0.842351 0.075
R-HSA-162582 Signal Transduction 0.852843 0.069
R-HSA-8856828 Clathrin-mediated endocytosis 0.853284 0.069
R-HSA-9711123 Cellular response to chemical stress 0.857398 0.067
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.858464 0.066
R-HSA-913531 Interferon Signaling 0.860050 0.065
R-HSA-2187338 Visual phototransduction 0.860150 0.065
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.861816 0.065
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.865089 0.063
R-HSA-9679191 Potential therapeutics for SARS 0.865089 0.063
R-HSA-9856651 MITF-M-dependent gene expression 0.865089 0.063
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.868285 0.061
R-HSA-446728 Cell junction organization 0.870154 0.060
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.871405 0.060
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 0.875949 0.058
R-HSA-9711097 Cellular response to starvation 0.877428 0.057
R-HSA-1483257 Phospholipid metabolism 0.889465 0.051
R-HSA-5619102 SLC transporter disorders 0.889971 0.051
R-HSA-195721 Signaling by WNT 0.892585 0.049
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.895128 0.048
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.898837 0.046
R-HSA-9664433 Leishmania parasite growth and survival 0.898837 0.046
R-HSA-392499 Metabolism of proteins 0.902468 0.045
R-HSA-1500931 Cell-Cell communication 0.909655 0.041
R-HSA-112315 Transmission across Chemical Synapses 0.915583 0.038
R-HSA-8957322 Metabolism of steroids 0.916400 0.038
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.919479 0.036
R-HSA-9609690 HCMV Early Events 0.923259 0.035
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.923276 0.035
R-HSA-428157 Sphingolipid metabolism 0.927737 0.033
R-HSA-9640148 Infection with Enterobacteria 0.929454 0.032
R-HSA-5683057 MAPK family signaling cascades 0.933261 0.030
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.937451 0.028
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.945045 0.025
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.949639 0.022
R-HSA-15869 Metabolism of nucleotides 0.953152 0.021
R-HSA-157118 Signaling by NOTCH 0.955357 0.020
R-HSA-425407 SLC-mediated transmembrane transport 0.959916 0.018
R-HSA-76002 Platelet activation, signaling and aggregation 0.970383 0.013
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.972119 0.012
R-HSA-5673001 RAF/MAP kinase cascade 0.975294 0.011
R-HSA-5684996 MAPK1/MAPK3 signaling 0.977300 0.010
R-HSA-112316 Neuronal System 0.980681 0.008
R-HSA-71291 Metabolism of amino acids and derivatives 0.982543 0.008
R-HSA-449147 Signaling by Interleukins 0.983667 0.007
R-HSA-196854 Metabolism of vitamins and cofactors 0.990047 0.004
R-HSA-1280215 Cytokine Signaling in Immune system 0.991023 0.004
R-HSA-9824439 Bacterial Infection Pathways 0.992833 0.003
R-HSA-109582 Hemostasis 0.996585 0.001
R-HSA-382551 Transport of small molecules 0.997996 0.001
R-HSA-9709957 Sensory Perception 0.999353 0.000
R-HSA-388396 GPCR downstream signalling 0.999937 0.000
R-HSA-372790 Signaling by GPCR 0.999978 0.000
R-HSA-556833 Metabolism of lipids 0.999990 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.870 0.149 2 0.891
CDC7CDC7 0.866 0.175 1 0.871
PIM3PIM3 0.864 0.130 -3 0.829
CLK3CLK3 0.863 0.178 1 0.824
RSK2RSK2 0.862 0.156 -3 0.769
NDR2NDR2 0.859 0.080 -3 0.839
DSTYKDSTYK 0.857 0.071 2 0.913
PRKD1PRKD1 0.856 0.118 -3 0.827
CAMK1BCAMK1B 0.856 0.086 -3 0.862
IKKBIKKB 0.856 -0.003 -2 0.724
CAMK2GCAMK2G 0.856 0.064 2 0.853
MOSMOS 0.855 0.068 1 0.863
GRK6GRK6 0.854 0.222 1 0.876
RAF1RAF1 0.854 0.002 1 0.841
PIM1PIM1 0.853 0.129 -3 0.777
PRPKPRPK 0.853 -0.112 -1 0.859
P90RSKP90RSK 0.853 0.096 -3 0.772
MAPKAPK2MAPKAPK2 0.852 0.129 -3 0.726
PRKD2PRKD2 0.852 0.110 -3 0.776
HUNKHUNK 0.851 0.052 2 0.845
GRK1GRK1 0.851 0.138 -2 0.717
SKMLCKSKMLCK 0.851 0.122 -2 0.805
IKKAIKKA 0.850 0.089 -2 0.699
NDR1NDR1 0.850 0.039 -3 0.835
NLKNLK 0.850 0.051 1 0.816
CAMK2BCAMK2B 0.850 0.167 2 0.822
LATS2LATS2 0.850 0.070 -5 0.716
MARK4MARK4 0.850 0.075 4 0.839
ULK2ULK2 0.849 -0.092 2 0.821
AMPKA1AMPKA1 0.849 0.093 -3 0.861
GCN2GCN2 0.849 -0.162 2 0.848
ERK5ERK5 0.848 0.092 1 0.798
TBK1TBK1 0.848 -0.077 1 0.732
ATRATR 0.848 0.013 1 0.824
RSK3RSK3 0.848 0.069 -3 0.768
PKN3PKN3 0.848 0.020 -3 0.830
NUAK2NUAK2 0.848 0.055 -3 0.845
PDHK4PDHK4 0.847 -0.196 1 0.834
BMPR1BBMPR1B 0.847 0.246 1 0.869
MTORMTOR 0.847 -0.118 1 0.766
GRK5GRK5 0.847 0.004 -3 0.844
CAMK2DCAMK2D 0.847 0.056 -3 0.840
MST4MST4 0.847 0.050 2 0.889
AURCAURC 0.847 0.141 -2 0.663
BMPR2BMPR2 0.847 -0.127 -2 0.823
TSSK2TSSK2 0.847 0.108 -5 0.803
WNK1WNK1 0.846 0.020 -2 0.815
IKKEIKKE 0.846 -0.065 1 0.733
CAMK2ACAMK2A 0.846 0.145 2 0.840
MAPKAPK3MAPKAPK3 0.846 0.055 -3 0.783
CAMLCKCAMLCK 0.846 0.059 -2 0.824
FAM20CFAM20C 0.845 0.124 2 0.652
PKACGPKACG 0.845 0.072 -2 0.733
NIKNIK 0.845 0.016 -3 0.882
CDKL1CDKL1 0.845 0.010 -3 0.791
P70S6KBP70S6KB 0.845 0.064 -3 0.797
TSSK1TSSK1 0.845 0.104 -3 0.882
TGFBR1TGFBR1 0.844 0.165 -2 0.752
AMPKA2AMPKA2 0.844 0.086 -3 0.828
RSK4RSK4 0.844 0.133 -3 0.734
DAPK2DAPK2 0.844 0.074 -3 0.867
PKN2PKN2 0.843 0.034 -3 0.843
PDHK1PDHK1 0.843 -0.169 1 0.818
PKCDPKCD 0.843 0.069 2 0.830
PKACBPKACB 0.843 0.139 -2 0.684
SRPK1SRPK1 0.843 0.057 -3 0.744
TGFBR2TGFBR2 0.842 -0.042 -2 0.742
MSK1MSK1 0.842 0.119 -3 0.745
PRKXPRKX 0.842 0.171 -3 0.686
NEK6NEK6 0.841 -0.079 -2 0.782
PAK1PAK1 0.841 0.073 -2 0.775
LATS1LATS1 0.841 0.123 -3 0.853
NEK7NEK7 0.840 -0.133 -3 0.827
CHAK2CHAK2 0.840 -0.015 -1 0.884
ALK4ALK4 0.839 0.098 -2 0.781
ULK1ULK1 0.839 -0.124 -3 0.819
MSK2MSK2 0.839 0.046 -3 0.732
RIPK3RIPK3 0.839 -0.079 3 0.653
PLK1PLK1 0.839 0.064 -2 0.766
CDKL5CDKL5 0.839 0.005 -3 0.785
NIM1NIM1 0.838 -0.018 3 0.736
BCKDKBCKDK 0.838 -0.101 -1 0.830
CLK2CLK2 0.838 0.162 -3 0.753
GRK7GRK7 0.837 0.125 1 0.811
DLKDLK 0.837 -0.030 1 0.835
MNK2MNK2 0.837 0.070 -2 0.777
HIPK4HIPK4 0.837 -0.002 1 0.759
ICKICK 0.837 0.003 -3 0.829
ATMATM 0.836 0.025 1 0.777
MLK1MLK1 0.836 -0.116 2 0.851
PAK6PAK6 0.836 0.113 -2 0.729
PAK3PAK3 0.836 0.019 -2 0.783
QSKQSK 0.836 0.063 4 0.807
AURBAURB 0.835 0.096 -2 0.668
ALK2ALK2 0.835 0.145 -2 0.760
WNK3WNK3 0.835 -0.173 1 0.790
CLK4CLK4 0.835 0.091 -3 0.769
GRK4GRK4 0.835 -0.073 -2 0.742
MARK3MARK3 0.834 0.093 4 0.787
PRKD3PRKD3 0.834 0.042 -3 0.751
CHK1CHK1 0.834 0.070 -3 0.838
KISKIS 0.834 -0.005 1 0.681
CAMK4CAMK4 0.834 -0.029 -3 0.824
SRPK2SRPK2 0.834 0.037 -3 0.664
NEK9NEK9 0.833 -0.116 2 0.868
MASTLMASTL 0.833 -0.234 -2 0.759
MELKMELK 0.833 0.010 -3 0.815
MNK1MNK1 0.832 0.071 -2 0.788
ACVR2BACVR2B 0.832 0.118 -2 0.748
BMPR1ABMPR1A 0.832 0.202 1 0.845
ACVR2AACVR2A 0.832 0.100 -2 0.734
SIKSIK 0.832 0.036 -3 0.763
MYLK4MYLK4 0.832 0.068 -2 0.764
BRSK1BRSK1 0.832 0.039 -3 0.799
MARK2MARK2 0.832 0.075 4 0.749
PKRPKR 0.832 0.036 1 0.809
CLK1CLK1 0.831 0.083 -3 0.752
CDK8CDK8 0.831 -0.006 1 0.654
AURAAURA 0.831 0.088 -2 0.640
NUAK1NUAK1 0.831 -0.003 -3 0.799
DNAPKDNAPK 0.831 0.070 1 0.703
PLK3PLK3 0.831 0.014 2 0.800
PKG2PKG2 0.830 0.069 -2 0.683
JNK2JNK2 0.830 0.093 1 0.621
RIPK1RIPK1 0.830 -0.151 1 0.782
ANKRD3ANKRD3 0.830 -0.151 1 0.837
PKCBPKCB 0.829 0.022 2 0.779
JNK3JNK3 0.829 0.075 1 0.649
QIKQIK 0.829 -0.040 -3 0.835
MLK2MLK2 0.829 -0.131 2 0.853
MARK1MARK1 0.829 0.064 4 0.800
DYRK2DYRK2 0.828 0.025 1 0.688
PIM2PIM2 0.828 0.058 -3 0.747
MEK1MEK1 0.828 -0.077 2 0.866
SGK3SGK3 0.827 0.053 -3 0.771
PKCGPKCG 0.827 -0.003 2 0.785
TTBK2TTBK2 0.827 -0.171 2 0.745
PAK2PAK2 0.826 -0.008 -2 0.766
AKT2AKT2 0.826 0.058 -3 0.689
NEK2NEK2 0.826 -0.060 2 0.845
PKCAPKCA 0.825 0.007 2 0.775
CDK7CDK7 0.825 -0.011 1 0.666
PKACAPKACA 0.825 0.097 -2 0.639
CDK19CDK19 0.825 -0.007 1 0.616
CDK5CDK5 0.825 0.035 1 0.687
MLK3MLK3 0.824 -0.073 2 0.793
YSK4YSK4 0.824 -0.102 1 0.769
IRE1IRE1 0.824 -0.131 1 0.749
CDK1CDK1 0.824 0.029 1 0.645
SSTKSSTK 0.824 0.080 4 0.791
CDK13CDK13 0.824 0.000 1 0.638
BRSK2BRSK2 0.824 -0.037 -3 0.826
DCAMKL1DCAMKL1 0.824 0.029 -3 0.797
SMG1SMG1 0.824 -0.022 1 0.767
SRPK3SRPK3 0.824 -0.011 -3 0.710
PKCHPKCH 0.823 -0.017 2 0.768
TLK2TLK2 0.823 -0.065 1 0.790
DRAK1DRAK1 0.823 0.052 1 0.823
CK2A2CK2A2 0.823 0.187 1 0.755
VRK2VRK2 0.823 -0.203 1 0.839
GRK2GRK2 0.822 0.027 -2 0.644
P38AP38A 0.822 0.027 1 0.697
MLK4MLK4 0.821 -0.075 2 0.773
P38BP38B 0.821 0.045 1 0.640
PASKPASK 0.821 0.101 -3 0.838
IRE2IRE2 0.821 -0.111 2 0.789
CDK2CDK2 0.821 -0.003 1 0.733
PKCZPKCZ 0.820 -0.043 2 0.815
CAMK1GCAMK1G 0.820 -0.010 -3 0.758
BRAFBRAF 0.820 -0.022 -4 0.821
P38GP38G 0.819 0.040 1 0.555
CDK18CDK18 0.819 0.018 1 0.602
CHAK1CHAK1 0.818 -0.144 2 0.807
GSK3BGSK3B 0.818 0.079 4 0.514
CDK9CDK9 0.818 -0.010 1 0.644
CAMK1DCAMK1D 0.818 0.052 -3 0.692
P70S6KP70S6K 0.817 0.007 -3 0.707
HIPK1HIPK1 0.817 0.032 1 0.696
PHKG1PHKG1 0.817 -0.102 -3 0.826
MAPKAPK5MAPKAPK5 0.817 -0.097 -3 0.713
HIPK2HIPK2 0.817 0.036 1 0.598
GSK3AGSK3A 0.817 0.097 4 0.526
ERK1ERK1 0.816 0.012 1 0.621
ERK2ERK2 0.816 0.002 1 0.663
AKT1AKT1 0.816 0.062 -3 0.710
CDK12CDK12 0.816 -0.003 1 0.614
PLK4PLK4 0.815 -0.120 2 0.669
SMMLCKSMMLCK 0.815 0.011 -3 0.815
CAMKK1CAMKK1 0.814 0.040 -2 0.776
DCAMKL2DCAMKL2 0.814 -0.018 -3 0.820
DYRK4DYRK4 0.814 0.038 1 0.617
MST3MST3 0.814 -0.002 2 0.872
SNRKSNRK 0.814 -0.182 2 0.703
PERKPERK 0.813 -0.173 -2 0.777
WNK4WNK4 0.813 -0.118 -2 0.803
P38DP38D 0.813 0.068 1 0.551
DAPK3DAPK3 0.813 0.082 -3 0.799
PRP4PRP4 0.813 0.022 -3 0.791
CK2A1CK2A1 0.813 0.168 1 0.740
MEKK1MEKK1 0.812 -0.139 1 0.790
DYRK1ADYRK1A 0.812 -0.008 1 0.718
CDK3CDK3 0.812 0.029 1 0.578
PAK5PAK5 0.812 0.035 -2 0.658
GAKGAK 0.811 0.047 1 0.818
CDK17CDK17 0.811 -0.003 1 0.560
PAK4PAK4 0.811 0.051 -2 0.658
NEK5NEK5 0.810 -0.105 1 0.800
PKCTPKCT 0.810 -0.033 2 0.774
MEKK3MEKK3 0.810 -0.186 1 0.803
DYRK1BDYRK1B 0.810 0.012 1 0.653
ZAKZAK 0.810 -0.166 1 0.766
PINK1PINK1 0.809 -0.178 1 0.779
TAO3TAO3 0.809 -0.058 1 0.791
HRIHRI 0.809 -0.237 -2 0.785
MEK5MEK5 0.809 -0.274 2 0.853
TLK1TLK1 0.809 -0.154 -2 0.747
CAMKK2CAMKK2 0.809 0.033 -2 0.765
MEKK2MEKK2 0.809 -0.152 2 0.837
PHKG2PHKG2 0.809 -0.051 -3 0.811
CDK14CDK14 0.809 0.012 1 0.647
IRAK4IRAK4 0.809 -0.112 1 0.754
LKB1LKB1 0.809 0.020 -3 0.841
GRK3GRK3 0.808 0.010 -2 0.598
CDK16CDK16 0.808 0.030 1 0.575
CDK10CDK10 0.808 0.041 1 0.630
PKCIPKCI 0.808 -0.016 2 0.788
DYRK3DYRK3 0.807 0.021 1 0.696
HIPK3HIPK3 0.807 -0.021 1 0.698
DAPK1DAPK1 0.807 0.076 -3 0.779
PLK2PLK2 0.807 0.043 -3 0.782
JNK1JNK1 0.807 0.047 1 0.614
MRCKAMRCKA 0.804 0.054 -3 0.758
PKCEPKCE 0.804 0.016 2 0.774
ROCK2ROCK2 0.804 0.082 -3 0.796
MRCKBMRCKB 0.804 0.059 -3 0.744
GCKGCK 0.803 0.005 1 0.818
SGK1SGK1 0.803 0.045 -3 0.605
AKT3AKT3 0.803 0.050 -3 0.621
NEK8NEK8 0.802 -0.153 2 0.849
TAO2TAO2 0.802 -0.107 2 0.881
ERK7ERK7 0.801 0.026 2 0.587
CK1ECK1E 0.801 -0.093 -3 0.512
MST2MST2 0.801 -0.064 1 0.820
CAMK1ACAMK1A 0.800 0.025 -3 0.653
TTBK1TTBK1 0.800 -0.174 2 0.661
SBKSBK 0.800 0.039 -3 0.566
TAK1TAK1 0.800 -0.047 1 0.815
TNIKTNIK 0.800 -0.027 3 0.788
MPSK1MPSK1 0.800 -0.090 1 0.731
NEK4NEK4 0.799 -0.096 1 0.771
EEF2KEEF2K 0.799 -0.059 3 0.773
MINKMINK 0.799 -0.054 1 0.784
IRAK1IRAK1 0.799 -0.234 -1 0.765
CHK2CHK2 0.799 -0.002 -3 0.637
HGKHGK 0.798 -0.064 3 0.785
PKN1PKN1 0.798 -0.032 -3 0.728
HPK1HPK1 0.798 -0.008 1 0.804
MEKK6MEKK6 0.798 -0.117 1 0.782
PDK1PDK1 0.798 -0.131 1 0.764
NEK11NEK11 0.798 -0.205 1 0.787
DMPK1DMPK1 0.796 0.092 -3 0.761
MAKMAK 0.796 0.037 -2 0.662
CDK4CDK4 0.795 0.005 1 0.602
NEK1NEK1 0.795 -0.071 1 0.773
LOKLOK 0.795 -0.070 -2 0.738
KHS1KHS1 0.795 0.001 1 0.778
CK1G1CK1G1 0.794 -0.122 -3 0.510
KHS2KHS2 0.794 0.030 1 0.798
LRRK2LRRK2 0.794 -0.149 2 0.876
MST1MST1 0.793 -0.081 1 0.794
VRK1VRK1 0.793 -0.149 2 0.861
CDK6CDK6 0.793 -0.005 1 0.617
CK1DCK1D 0.793 -0.087 -3 0.459
BUB1BUB1 0.792 0.039 -5 0.736
MAP3K15MAP3K15 0.792 -0.160 1 0.746
CK1A2CK1A2 0.791 -0.083 -3 0.459
PDHK3_TYRPDHK3_TYR 0.791 0.291 4 0.879
PBKPBK 0.790 -0.025 1 0.734
PKG1PKG1 0.790 0.007 -2 0.624
STK33STK33 0.790 -0.145 2 0.656
SLKSLK 0.790 -0.086 -2 0.664
ROCK1ROCK1 0.789 0.048 -3 0.760
CRIKCRIK 0.789 0.046 -3 0.700
MOKMOK 0.789 0.009 1 0.711
MEK2MEK2 0.788 -0.216 2 0.836
YSK1YSK1 0.787 -0.102 2 0.844
RIPK2RIPK2 0.782 -0.274 1 0.723
PDHK4_TYRPDHK4_TYR 0.779 0.106 2 0.901
OSR1OSR1 0.778 -0.117 2 0.828
NEK3NEK3 0.778 -0.182 1 0.724
BIKEBIKE 0.778 -0.008 1 0.685
MAP2K6_TYRMAP2K6_TYR 0.778 0.049 -1 0.880
TTKTTK 0.777 -0.103 -2 0.755
TESK1_TYRTESK1_TYR 0.776 -0.080 3 0.821
MAP2K4_TYRMAP2K4_TYR 0.776 -0.045 -1 0.877
BMPR2_TYRBMPR2_TYR 0.774 0.039 -1 0.857
HASPINHASPIN 0.773 -0.034 -1 0.756
ALPHAK3ALPHAK3 0.773 -0.057 -1 0.772
MYO3BMYO3B 0.773 -0.091 2 0.858
MAP2K7_TYRMAP2K7_TYR 0.773 -0.189 2 0.889
YANK3YANK3 0.772 -0.072 2 0.434
ASK1ASK1 0.772 -0.171 1 0.731
PKMYT1_TYRPKMYT1_TYR 0.771 -0.136 3 0.778
LIMK2_TYRLIMK2_TYR 0.770 -0.047 -3 0.892
PDHK1_TYRPDHK1_TYR 0.769 -0.076 -1 0.885
MYO3AMYO3A 0.769 -0.121 1 0.764
PINK1_TYRPINK1_TYR 0.769 -0.182 1 0.818
EPHA6EPHA6 0.769 0.024 -1 0.846
TAO1TAO1 0.765 -0.158 1 0.707
EPHB4EPHB4 0.764 -0.020 -1 0.834
RETRET 0.763 -0.177 1 0.788
AAK1AAK1 0.763 0.030 1 0.581
DDR1DDR1 0.762 -0.114 4 0.809
TXKTXK 0.760 0.079 1 0.874
LIMK1_TYRLIMK1_TYR 0.760 -0.234 2 0.883
STLK3STLK3 0.759 -0.208 1 0.745
CK1ACK1A 0.759 -0.084 -3 0.368
TYRO3TYRO3 0.759 -0.164 3 0.715
TYK2TYK2 0.759 -0.237 1 0.785
ROS1ROS1 0.759 -0.161 3 0.693
FERFER 0.758 -0.091 1 0.884
EPHA4EPHA4 0.758 -0.011 2 0.802
INSRRINSRR 0.757 -0.080 3 0.675
EPHB1EPHB1 0.757 -0.026 1 0.876
MST1RMST1R 0.756 -0.241 3 0.714
YES1YES1 0.756 -0.093 -1 0.821
SRMSSRMS 0.755 -0.030 1 0.885
JAK2JAK2 0.755 -0.235 1 0.778
EPHB3EPHB3 0.754 -0.054 -1 0.813
ABL2ABL2 0.754 -0.098 -1 0.800
EPHB2EPHB2 0.754 -0.029 -1 0.808
TNK2TNK2 0.753 -0.096 3 0.666
CSF1RCSF1R 0.753 -0.191 3 0.691
ITKITK 0.753 -0.046 -1 0.772
FGRFGR 0.753 -0.161 1 0.853
FGFR2FGFR2 0.751 -0.172 3 0.722
JAK3JAK3 0.750 -0.200 1 0.763
ABL1ABL1 0.750 -0.116 -1 0.792
TNNI3K_TYRTNNI3K_TYR 0.750 -0.092 1 0.771
NEK10_TYRNEK10_TYR 0.749 -0.132 1 0.656
AXLAXL 0.749 -0.135 3 0.688
TNK1TNK1 0.749 -0.130 3 0.698
PDGFRBPDGFRB 0.749 -0.204 3 0.710
BMXBMX 0.748 -0.035 -1 0.701
MERTKMERTK 0.748 -0.086 3 0.688
HCKHCK 0.747 -0.158 -1 0.787
DDR2DDR2 0.747 -0.039 3 0.652
TECTEC 0.747 -0.064 -1 0.727
FGFR1FGFR1 0.746 -0.204 3 0.685
FLT3FLT3 0.746 -0.210 3 0.706
TEKTEK 0.745 -0.202 3 0.664
EPHA7EPHA7 0.745 -0.066 2 0.804
BLKBLK 0.745 -0.075 -1 0.795
LCKLCK 0.745 -0.117 -1 0.786
KITKIT 0.744 -0.210 3 0.698
ALKALK 0.743 -0.160 3 0.632
NTRK1NTRK1 0.742 -0.177 -1 0.821
LTKLTK 0.742 -0.153 3 0.647
EPHA3EPHA3 0.742 -0.115 2 0.779
PTK2BPTK2B 0.741 -0.017 -1 0.768
JAK1JAK1 0.741 -0.176 1 0.725
KDRKDR 0.741 -0.224 3 0.652
FYNFYN 0.741 -0.060 -1 0.761
BTKBTK 0.740 -0.204 -1 0.741
EPHA5EPHA5 0.740 -0.047 2 0.787
CK1G3CK1G3 0.739 -0.108 -3 0.321
INSRINSR 0.739 -0.165 3 0.650
PTK6PTK6 0.739 -0.230 -1 0.713
WEE1_TYRWEE1_TYR 0.738 -0.167 -1 0.752
METMET 0.738 -0.205 3 0.686
FGFR3FGFR3 0.737 -0.197 3 0.689
PDGFRAPDGFRA 0.737 -0.313 3 0.702
YANK2YANK2 0.736 -0.110 2 0.451
EPHA1EPHA1 0.736 -0.176 3 0.663
FRKFRK 0.736 -0.149 -1 0.806
NTRK2NTRK2 0.735 -0.233 3 0.658
NTRK3NTRK3 0.735 -0.157 -1 0.772
ERBB2ERBB2 0.735 -0.223 1 0.771
EPHA8EPHA8 0.733 -0.100 -1 0.782
PTK2PTK2 0.733 0.014 -1 0.755
FLT1FLT1 0.733 -0.213 -1 0.816
FLT4FLT4 0.732 -0.248 3 0.659
EGFREGFR 0.732 -0.099 1 0.691
MATKMATK 0.732 -0.160 -1 0.741
LYNLYN 0.730 -0.181 3 0.621
SRCSRC 0.729 -0.133 -1 0.767
CSKCSK 0.729 -0.174 2 0.803
SYKSYK 0.729 -0.027 -1 0.738
FGFR4FGFR4 0.727 -0.145 -1 0.759
EPHA2EPHA2 0.725 -0.096 -1 0.747
IGF1RIGF1R 0.724 -0.157 3 0.599
MUSKMUSK 0.721 -0.167 1 0.686
ERBB4ERBB4 0.718 -0.098 1 0.735
CK1G2CK1G2 0.718 -0.126 -3 0.420
FESFES 0.710 -0.132 -1 0.683
ZAP70ZAP70 0.698 -0.121 -1 0.676