Motif 714 (n=266)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S230 | ochoa | Golgin A8 family member Q | None |
| A6NHR9 | SMCHD1 | S1974 | ochoa | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}. |
| A6NMY6 | ANXA2P2 | S134 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| I6L899 | GOLGA8R | S230 | ochoa | Golgin subfamily A member 8R | None |
| M0QZ92 | None | S40 | ochoa | SEC7 domain-containing protein | None |
| M0R2C6 | None | S196 | ochoa | serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (Seryl-tRNA(Ser/Sec) synthetase) | None |
| O00750 | PIK3C2B | Y228 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) | Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:11533253, PubMed:9830063). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). {ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11533253, ECO:0000269|PubMed:9830063}. |
| O14579 | COPE | S76 | ochoa | Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| O15155 | BET1 | S69 | ochoa | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | Required for vesicular transport from the ER to the Golgi complex (PubMed:34779586). Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). {ECO:0000250|UniProtKB:Q62896, ECO:0000269|PubMed:34779586}. |
| O43156 | TTI1 | T805 | ochoa | TELO2-interacting protein 1 homolog (Protein SMG10) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650, ECO:0000269|PubMed:36724785}. |
| O43707 | ACTN4 | S191 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43747 | AP1G1 | S229 | ochoa | AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000269|PubMed:34102099}. |
| O60260 | PRKN | S378 | psp | E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2) | Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:29311685, PubMed:32047033). Substrates include SYT11 and VDAC1 (PubMed:29311685, PubMed:32047033). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25474007, PubMed:25621951, PubMed:32047033). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11431533, PubMed:11590439, PubMed:15105460, PubMed:15728840, PubMed:19229105). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:11439185, PubMed:18957282, PubMed:19029340, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24660806, PubMed:24784582, PubMed:24896179, PubMed:25474007, PubMed:25527291, PubMed:32047033). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:11439185, PubMed:19029340, PubMed:19801972, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291, PubMed:32047033, PubMed:33499712). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:24660806, PubMed:24784582, PubMed:25474007, PubMed:25527291). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:27534820, PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:21753002, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (PubMed:25621951, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:23620051). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:23620051). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed:21376232). Limits the production of reactive oxygen species (ROS) (PubMed:18541373). Regulates cyclin-E during neuronal apoptosis (PubMed:12628165). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (PubMed:12719539). {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:10973942, ECO:0000269|PubMed:11431533, ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:11590439, ECO:0000269|PubMed:12150907, ECO:0000269|PubMed:12628165, ECO:0000269|PubMed:12719539, ECO:0000269|PubMed:15105460, ECO:0000269|PubMed:15728840, ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19029340, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19801972, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23685073, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951, ECO:0000269|PubMed:27534820, ECO:0000269|PubMed:29311685, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:33499712}. |
| O60271 | SPAG9 | S314 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60353 | FZD6 | S606 | ochoa | Frizzled-6 (Fz-6) (hFz6) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
| O60583 | CCNT2 | S707 | ochoa | Cyclin-T2 (CycT2) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:15563843, PubMed:9499409). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). {ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533, ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689, ECO:0000269|PubMed:9499409}.; FUNCTION: (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. {ECO:0000269|PubMed:21509660}. |
| O60784 | TOM1 | S359 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O75152 | ZC3H11A | S295 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75179 | ANKRD17 | S207 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75391 | SPAG7 | S158 | ochoa | Sperm-associated antigen 7 | None |
| O75665 | OFD1 | S954 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75688 | PPM1B | S376 | ochoa | Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}. |
| O75995 | SASH3 | Y116 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O94953 | KDM4B | S1036 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O95235 | KIF20A | S754 | psp | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95613 | PCNT | S1703 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95696 | BRD1 | S502 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| P01009 | SERPINA1 | S38 | ochoa | Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)] | Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; FUNCTION: [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). |
| P04035 | HMGCR | S504 | ochoa | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799). {ECO:0000269|PubMed:11349148, ECO:0000269|PubMed:18540668, ECO:0000269|PubMed:21357570, ECO:0000269|PubMed:2991281, ECO:0000269|PubMed:36745799, ECO:0000269|PubMed:6995544}. |
| P04049 | RAF1 | S604 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04629 | NTRK1 | S677 | ochoa | High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA) | Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1281417, PubMed:15488758, PubMed:17196528, PubMed:1849459, PubMed:1850821, PubMed:22649032, PubMed:27445338, PubMed:8325889). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250|UniProtKB:P35739, ECO:0000250|UniProtKB:Q3UFB7, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:17196528, ECO:0000269|PubMed:1849459, ECO:0000269|PubMed:1850821, ECO:0000269|PubMed:22649032, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:8155326, ECO:0000269|PubMed:8325889}.; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. {ECO:0000269|PubMed:15488758}. |
| P05060 | CHGB | S617 | ochoa|psp | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P05062 | ALDOB | S36 | ochoa | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). {ECO:0000269|PubMed:10970798, ECO:0000269|PubMed:12205126, ECO:0000269|PubMed:20848650, ECO:0000269|PubMed:35122041}. |
| P06748 | NPM1 | S43 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07355 | ANXA2 | S134 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07900 | HSP90AA1 | S68 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P07948 | LYN | S269 | ochoa | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P08238 | HSP90AB1 | S63 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | Y457 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P0DPH7 | TUBA3C | Y272 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | Y272 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P11171 | EPB41 | S674 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12036 | NEFH | S124 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12081 | HARS1 | S27 | ochoa | Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) | Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516). {ECO:0000269|PubMed:26072516, ECO:0000269|PubMed:29235198}. |
| P12814 | ACTN1 | S172 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12882 | MYH1 | S1726 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1722 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1724 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1725 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14598 | NCF1 | S370 | psp | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
| P15924 | DSP | S2000 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P15924 | DSP | S2242 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16066 | NPR1 | S519 | psp | Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499). {ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:36016499, ECO:0000269|PubMed:39543315}. |
| P17040 | ZSCAN20 | S637 | ochoa | Zinc finger and SCAN domain-containing protein 20 (Zinc finger protein 31) (Zinc finger protein 360) (Zinc finger protein KOX29) | May be involved in transcriptional regulation. |
| P17480 | UBTF | S638 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P17568 | NDUFB7 | S73 | ochoa | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (Cell adhesion protein SQM1) (Complex I-B18) (CI-B18) (NADH-ubiquinone oxidoreductase B18 subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:33502047}. |
| P17661 | DES | S358 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P17844 | DDX5 | S480 | ochoa | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| P18206 | VCL | S596 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P19174 | PLCG1 | S1248 | ochoa|psp | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P21796 | VDAC1 | S101 | ochoa | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P24539 | ATP5PB | S155 | ochoa | ATP synthase peripheral stalk subunit b, mitochondrial (ATP synthase F(0) complex subunit B1, mitochondrial) (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b) | Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13619, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P26010 | ITGB7 | S774 | ochoa | Integrin beta-7 (Gut homing receptor beta subunit) | Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract (PubMed:10837471, PubMed:14608374). Also interacts with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable). Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin (PubMed:10837471). {ECO:0000269|PubMed:10837471, ECO:0000269|PubMed:14608374, ECO:0000305|PubMed:12297042}.; FUNCTION: (Microbial infection) Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. {ECO:0000269|PubMed:18264102}. |
| P26045 | PTPN3 | S419 | ochoa | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
| P27694 | RPA1 | S315 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P28290 | ITPRID2 | S376 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29353 | SHC1 | S453 | ochoa | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P31939 | ATIC | S269 | ochoa | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P35221 | CTNNA1 | S48 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35228 | NOS2 | S80 | ochoa | Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2) | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109). {ECO:0000250|UniProtKB:P29477, ECO:0000269|PubMed:19688109, ECO:0000269|PubMed:25417112, ECO:0000269|PubMed:7504305, ECO:0000269|PubMed:7531687, ECO:0000269|PubMed:7544004, ECO:0000269|PubMed:7682706}. |
| P35523 | CLCN1 | S886 | ochoa | Chloride channel protein 1 (ClC-1) (Chloride channel protein, skeletal muscle) | Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing (PubMed:12456816, PubMed:16027167, PubMed:22521272, PubMed:22641783, PubMed:26007199, PubMed:26502825, PubMed:26510092, PubMed:7951242, PubMed:8112288, PubMed:8130334, PubMed:9122265, PubMed:9565403, PubMed:9736777). Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization (PubMed:10051520, PubMed:10962018, PubMed:29809153, PubMed:31022181). Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide (PubMed:9122265, PubMed:9565403). {ECO:0000269|PubMed:10051520, ECO:0000269|PubMed:10962018, ECO:0000269|PubMed:12456816, ECO:0000269|PubMed:16027167, ECO:0000269|PubMed:22521272, ECO:0000269|PubMed:22641783, ECO:0000269|PubMed:26007199, ECO:0000269|PubMed:26502825, ECO:0000269|PubMed:26510092, ECO:0000269|PubMed:29809153, ECO:0000269|PubMed:31022181, ECO:0000269|PubMed:7951242, ECO:0000269|PubMed:8112288, ECO:0000269|PubMed:8130334, ECO:0000269|PubMed:9122265, ECO:0000269|PubMed:9565403, ECO:0000269|PubMed:9736777}. |
| P35579 | MYH9 | S1803 | psp | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35659 | DEK | S72 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P36897 | TGFBR1 | S360 | ochoa | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis (PubMed:33914044). The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}. |
| P36955 | SERPINF1 | S114 | psp | Pigment epithelium-derived factor (PEDF) (Cell proliferation-inducing gene 35 protein) (EPC-1) (Serpin F1) | Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}. |
| P43490 | NAMPT | S470 | ochoa | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}. |
| P46939 | UTRN | S2615 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P48681 | NES | S680 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49792 | RANBP2 | S1819 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49902 | NT5C2 | S408 | ochoa | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P50502 | ST13 | S181 | ochoa | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| P50613 | CDK7 | S164 | ochoa|psp | Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) | Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription (PubMed:9852112, PubMed:19136461, PubMed:26257281, PubMed:28768201). Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201). Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, PubMed:28768201). CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the CTD of POLR2A, allowing its escape from the promoter and elongation of the transcripts (PubMed:9852112). Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, ECO:0000269|PubMed:9372954, ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| P52272 | HNRNPM | S588 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P53004 | BLVRA | S149 | psp | Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) | Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}. |
| P54105 | CLNS1A | S197 | ochoa | Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) | Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:10330151, PubMed:18984161). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161). {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713266, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. |
| P54296 | MYOM2 | S549 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54296 | MYOM2 | S1042 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P55087 | AQP4 | S180 | psp | Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) | Forms a water-specific channel (PubMed:19383790, PubMed:7559426, PubMed:8601457). Plays an important role in brain water homeostasis (PubMed:37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). {ECO:0000250|UniProtKB:P55088, ECO:0000269|PubMed:19383790, ECO:0000269|PubMed:37143309, ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}. |
| P59923 | ZNF445 | S150 | ochoa | Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15) | Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). {ECO:0000269|PubMed:30602440}. |
| P61244 | MAX | S108 | ochoa | Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}. |
| P68104 | EEF1A1 | S83 | ochoa | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| P68363 | TUBA1B | Y272 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | Y272 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78527 | PRKDC | S2056 | psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P78559 | MAP1A | S874 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q00341 | HDLBP | S363 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q08945 | SSRP1 | S375 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q0ZGT2 | NEXN | S357 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12873 | CHD3 | S1819 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q12929 | EPS8 | S476 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q12955 | ANK3 | S4229 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13033 | STRN3 | S322 | ochoa | Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}. |
| Q13555 | CAMK2G | S311 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13563 | PKD2 | S802 | ochoa | Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) | Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}. |
| Q14676 | MDC1 | S763 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14789 | GOLGB1 | S1571 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15149 | PLEC | S3143 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15672 | TWIST1 | S144 | psp | Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist) | Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:P26687, ECO:0000269|PubMed:12553906, ECO:0000269|PubMed:25981568}. |
| Q15743 | GPR68 | S328 | ochoa | G-protein coupled receptor 68 (G-protein coupled receptor 12A) (GPR12A) (Ovarian cancer G-protein coupled receptor 1) (OGR-1) | Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed:33478938, PubMed:39753132). The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:29677517, PubMed:39753132). GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:29677517, PubMed:39753132). Acts as a key mechanosensor of fluid shear stress and membrane stretch (PubMed:29677517, PubMed:30471999). Expressed in endothelial cells of small-diameter resistance arteries, where it mediates flow-induced dilation in response to shear stress (PubMed:29677517). May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone (By similarity). Acts as a regulator of calcium-sensing receptor CASR in a seesaw manner: GPR68-mediated signaling inhibits CASR signaling in response to protons, while CASR inhibits GPR68 in presence of extracellular calcium (By similarity). {ECO:0000250|UniProtKB:Q8BFQ3, ECO:0000269|PubMed:12955148, ECO:0000269|PubMed:29677517, ECO:0000269|PubMed:30471999, ECO:0000269|PubMed:32865988, ECO:0000269|PubMed:33478938, ECO:0000269|PubMed:39753132}. |
| Q15751 | HERC1 | S1333 | ochoa | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q15911 | ZFHX3 | S519 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q16204 | CCDC6 | S328 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16760 | DGKD | S668 | ochoa | Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q2M1Z3 | ARHGAP31 | S596 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q58FF6 | HSP90AB4P | S39 | ochoa | Putative heat shock protein HSP 90-beta 4 | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF7 | HSP90AB3P | S63 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF8 | HSP90AB2P | S63 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5T4S7 | UBR4 | S4117 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5TCZ1 | SH3PXD2A | S634 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5TZA2 | CROCC | S1660 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5VTE0 | EEF1A1P5 | S83 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q5VZ89 | DENND4C | S1104 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q63HN8 | RNF213 | S1128 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q6DN90 | IQSEC1 | S913 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6P0N0 | MIS18BP1 | S894 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P0Q8 | MAST2 | S895 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P996 | PDXDC1 | S572 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6P9F7 | LRRC8B | S201 | ochoa | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}. |
| Q6PEY2 | TUBA3E | Y272 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6Y2X3 | DNAJC14 | S187 | ochoa | DnaJ homolog subfamily C member 14 (DnaJ protein homolog 3) (Dopamine receptor-interacting protein of 78 kDa) (DRIP78) (Human DnaJ protein 3) (hDj-3) | Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000250}. |
| Q6ZS30 | NBEAL1 | S315 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q709C8 | VPS13C | S1398 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
| Q71U36 | TUBA1A | Y272 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7L4E1 | MIGA2 | S203 | ochoa | Mitoguardin 2 (Protein FAM73B) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q7Z2D5 | PLPPR4 | S364 | ochoa | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) | Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). {ECO:0000250|UniProtKB:Q7TMB7, ECO:0000250|UniProtKB:Q7TME0}. |
| Q7Z309 | PABIR2 | S55 | ochoa | PABIR family member 2 | None |
| Q7Z3D4 | LYSMD3 | S53 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 3 | Essential for Golgi structural integrity. {ECO:0000269|PubMed:29851555}. |
| Q7Z4H7 | HAUS6 | S569 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z5J4 | RAI1 | S670 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q86V48 | LUZP1 | S608 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86XA9 | HEATR5A | S1647 | ochoa | HEAT repeat-containing protein 5A | None |
| Q86YV0 | RASAL3 | S228 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IVT2 | MISP | S575 | ochoa|psp | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWA4 | MFN1 | S284 | psp | Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303). {ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:27920125, ECO:0000269|PubMed:28114303}. |
| Q8IWU2 | LMTK2 | S617 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IWZ3 | ANKHD1 | S178 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IZP2 | ST13P4 | S177 | ochoa | Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4) | None |
| Q8N9U0 | TC2N | S102 | ochoa | Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) | None |
| Q8NB16 | MLKL | S358 | psp | Mixed lineage kinase domain-like protein (hMLKL) | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610). {ECO:0000250|UniProtKB:Q9D2Y4, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:29883610}. |
| Q8NCY6 | MSANTD4 | S286 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 4 (Myb/SANT-like DNA-binding domain containing 4 with coiled-coils) | None |
| Q8NFC6 | BOD1L1 | S1098 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NG08 | HELB | S708 | ochoa | DNA helicase B (hDHB) (EC 3.6.4.12) | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). {ECO:0000269|PubMed:12181327, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:25617833, ECO:0000269|PubMed:26774285}. |
| Q8NHV4 | NEDD1 | S94 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8NI27 | THOC2 | S1448 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TDY2 | RB1CC1 | S982 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8WUF5 | PPP1R13L | S292 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WYQ5 | DGCR8 | S271 | ochoa|psp | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q92560 | BAP1 | S276 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92574 | TSC1 | S270 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92615 | LARP4B | S451 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92797 | SYMPK | S1081 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q96B67 | ARRDC3 | S395 | ochoa | Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP) | Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550). {ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}. |
| Q96BD8 | SKA1 | S76 | ochoa | SKA complex subunit 1 (Spindle and kinetochore-associated protein 1) | Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint (PubMed:17093495, PubMed:19289083, PubMed:22371557, PubMed:22483620, PubMed:23085020, PubMed:26981768, PubMed:27697923, PubMed:29487209, PubMed:31804178). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:19289083, PubMed:22483620, PubMed:23085020, PubMed:28479321, PubMed:29487209). The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17093495, PubMed:19289083, PubMed:23085020, PubMed:28479321, PubMed:29487209). The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces (PubMed:19289083, PubMed:22371557, PubMed:22454517, PubMed:23085020, PubMed:24413531, PubMed:27697923, PubMed:28479321, PubMed:28495837, PubMed:29487209). The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules (PubMed:23085020, PubMed:29153323). The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase (PubMed:26981768). In the complex, it mediates interactions with microtubules (PubMed:19289083, PubMed:22483620, PubMed:23085020, PubMed:24413531, PubMed:27667719, PubMed:29153323, PubMed:36592928). It also stimulates AURKB/Aurora B catalytic activity (PubMed:27697923). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity). {ECO:0000250|UniProtKB:Q9CPV1, ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:22371557, ECO:0000269|PubMed:22454517, ECO:0000269|PubMed:22483620, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:24413531, ECO:0000269|PubMed:26981768, ECO:0000269|PubMed:27667719, ECO:0000269|PubMed:27697923, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:28495837, ECO:0000269|PubMed:29153323, ECO:0000269|PubMed:29487209, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:36592928}. |
| Q96CV9 | OPTN | S170 | ochoa | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
| Q96CV9 | OPTN | S519 | ochoa | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
| Q96DT7 | ZBTB10 | S628 | ochoa | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | May be involved in transcriptional regulation. |
| Q96DT7 | ZBTB10 | S647 | ochoa | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | May be involved in transcriptional regulation. |
| Q96EA4 | SPDL1 | S546 | ochoa | Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1) | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100). {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:30258100}. |
| Q96EN8 | MOCOS | S682 | ochoa | Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) | Sulfurates the molybdenum cofactor (PubMed:34356852). Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form (PubMed:34356852). In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime (PubMed:16973608). {ECO:0000255|HAMAP-Rule:MF_03050, ECO:0000269|PubMed:16973608, ECO:0000269|PubMed:34356852}. |
| Q96FF7 | MISP3 | S174 | ochoa | Uncharacterized protein MISP3 (MISP family member 3) | None |
| Q96GX5 | MASTL | S660 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96IT1 | ZNF496 | S391 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
| Q96L93 | KIF16B | S881 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96MK2 | RIPOR3 | S381 | ochoa | RIPOR family member 3 | None |
| Q96PU5 | NEDD4L | S327 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96R06 | SPAG5 | S110 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RL1 | UIMC1 | S547 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q99418 | CYTH2 | S56 | ochoa | Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) | Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}. |
| Q99459 | CDC5L | S358 | ochoa|psp | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99983 | OMD | S244 | ochoa | Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD) | May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. {ECO:0000250|UniProtKB:O77742}. |
| Q9BQE3 | TUBA1C | Y272 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BSH4 | TACO1 | S156 | ochoa | Translational activator of cytochrome c oxidase 1 (Coiled-coil domain-containing protein 44) (Translational activator of mitochondrially-encoded cytochrome c oxidase I) | Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. {ECO:0000269|PubMed:19503089}. |
| Q9BTC0 | DIDO1 | S805 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BWH6 | RPAP1 | S264 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BYW2 | SETD2 | S112 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZQ8 | NIBAN1 | S146 | ochoa | Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) | Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}. |
| Q9GZY8 | MFF | S234 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H1K1 | ISCU | S29 | ochoa | Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein) | [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled (PubMed:34824239). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (Probable) (PubMed:24971490, PubMed:29576242, PubMed:30031876, PubMed:34824239). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form (PubMed:23940031). May modulate NFS1 desulfurase activity in a zinc-dependent manner (PubMed:30031876). Modulates the interaction between FXN and the cysteine desulfurase complex (PubMed:29576242). {ECO:0000269|PubMed:23940031, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242, ECO:0000269|PubMed:30031876, ECO:0000269|PubMed:34824239, ECO:0000305|PubMed:23940031}.; FUNCTION: [Isoform 2]: Cytoplasmic scaffold protein, of the cytoplasmic core iron-sulfur cluster (ISC) assembly complex that provides the structural architecture on which the Fe-S clusters are assembled and may be involved in the cytoplasmic iron-sulfur protein biogenesis. {ECO:0000269|PubMed:16517407, ECO:0000269|PubMed:16527810, ECO:0000269|PubMed:29309586}. |
| Q9H211 | CDT1 | S143 | psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H497 | TOR3A | Y358 | ochoa | Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A) | None |
| Q9H4G4 | GLIPR2 | S55 | ochoa | Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) | None |
| Q9H5J0 | ZBTB3 | S213 | ochoa | Zinc finger and BTB domain-containing protein 3 | May be involved in transcriptional regulation. |
| Q9H845 | ACAD9 | S461 | ochoa | Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-) | As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852, PubMed:32320651). This moonlighting protein also has a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852). {ECO:0000269|PubMed:12359260, ECO:0000269|PubMed:16020546, ECO:0000269|PubMed:20816094, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:24158852, ECO:0000269|PubMed:32320651}. |
| Q9H892 | TTC12 | S67 | ochoa | Tetratricopeptide repeat protein 12 (TPR repeat protein 12) | Cytoplasmic protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both respiratory cells and sperm flagella. {ECO:0000269|PubMed:31978331}. |
| Q9HCN4 | GPN1 | S301 | ochoa | GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1) | Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:21768307, ECO:0000305|PubMed:11058119}. |
| Q9HCY8 | S100A14 | S77 | ochoa | Protein S100-A14 (S100 calcium-binding protein A14) (S114) | Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898, ECO:0000269|PubMed:22451655}. |
| Q9HD67 | MYO10 | S915 | ochoa | Unconventional myosin-X (Unconventional myosin-10) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed:27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893, ECO:0000269|PubMed:27580874}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250|UniProtKB:F8VQB6}. |
| Q9NP81 | SARS2 | S126 | ochoa | Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). {ECO:0000250|UniProtKB:Q9N0F3}. |
| Q9NQP4 | PFDN4 | S107 | ochoa | Prefoldin subunit 4 (Protein C-1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q9NRA8 | EIF4ENIF1 | S301 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NVI1 | FANCI | S1116 | ochoa | Fanconi anemia group I protein (Protein FACI) | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}. |
| Q9NYM9 | BET1L | S37 | ochoa | BET1-like protein (Golgi SNARE with a size of 15 kDa) (GOS-15) (GS15) (Vesicle transport protein GOS15) | Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity). {ECO:0000250|UniProtKB:O35152}. |
| Q9NZC9 | SMARCAL1 | S210 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9NZN5 | ARHGEF12 | S1273 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P0K7 | RAI14 | S386 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0L0 | VAPA | S216 | ochoa | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
| Q9P0L9 | PKD2L1 | S685 | psp | Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog) (Polycystin-L) (Polycystin-L1) | Homotetrameric, non-selective cation channel that is permeable to sodium, potassium, magnesium and calcium (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:30004384). Also forms functionnal heteromeric channels with PKD1, PKD1L1 and PKD1L3 (PubMed:23212381, PubMed:24336289). Pore-forming subunit of a heterotetrameric, non-selective cation channel, formed by PKD1L2 and PKD1L3, that is permeable to sodium, potassium, magnesium and calcium and which may act as a sour taste receptor in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect (PubMed:19812697, PubMed:23212381). The homomeric and heteromeric channels formed by PKD1L2 and PKD1L3 are activated by low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed:23212381). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). The PKD1L1:PKD2L1 complex channel is mechanosensitive only at high pressures and is highly temperature sensitive (PubMed:24336289). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1 that produces a transient increase in intracellular calcium concentration upon hypo-osmotic stimulation (200 mOsm) (By similarity). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity). {ECO:0000250|UniProtKB:A2A259, ECO:0000269|PubMed:10517637, ECO:0000269|PubMed:11959145, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381, ECO:0000269|PubMed:24336289, ECO:0000269|PubMed:25820328, ECO:0000269|PubMed:27754867, ECO:0000269|PubMed:29425510, ECO:0000269|PubMed:30004384}. |
| Q9P219 | CCDC88C | S951 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P227 | ARHGAP23 | S361 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2G1 | ANKIB1 | S884 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
| Q9P2G1 | ANKIB1 | S891 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
| Q9UBP0 | SPAST | S245 | ochoa | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}. |
| Q9UBT7 | CTNNAL1 | S538 | ochoa | Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) | May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). |
| Q9UDT6 | CLIP2 | S923 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UHB6 | LIMA1 | S692 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHN1 | POLG2 | S38 | ochoa | DNA polymerase subunit gamma-2 (DNA polymerase gamma accessory 55 kDa subunit) (p55) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta) | Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA. {ECO:0000269|PubMed:11477093, ECO:0000269|PubMed:11477094, ECO:0000269|PubMed:11504725, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:19837034, ECO:0000269|PubMed:26056153, ECO:0000269|PubMed:30157269, ECO:0000269|PubMed:31778857, ECO:0000269|PubMed:37202477}. |
| Q9UIG0 | BAZ1B | S705 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UKX2 | MYH2 | S1728 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULF5 | SLC39A10 | S556 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9UN81 | L1RE1 | S166 | ochoa | LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1) | Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269|PubMed:11158327, ECO:0000269|PubMed:21937507, ECO:0000269|PubMed:28806172, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:8945518}. |
| Q9UP95 | SLC12A4 | S88 | ochoa | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}. |
| Q9UPT6 | MAPK8IP3 | S1191 | ochoa | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}. |
| Q9UPV0 | CEP164 | S1031 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UQ35 | SRRM2 | S144 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQR1 | ZNF148 | S698 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9Y217 | MTMR6 | S588 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 (EC 3.1.3.95) (Myotubularin-related protein 6) (Phosphatidylinositol-3-phosphate phosphatase) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:19038970, PubMed:22647598). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315, ECO:0000269|PubMed:19038970, ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:24591580, ECO:0000305|PubMed:24591580}. |
| Q9Y2D8 | SSX2IP | S452 | ochoa | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}. |
| Q9Y2J4 | AMOTL2 | S534 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y2K6 | USP20 | S263 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y365 | STARD10 | S250 | ochoa | START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10) | May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes. {ECO:0000250, ECO:0000269|PubMed:15911624}. |
| Q9Y490 | TLN1 | S604 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y490 | TLN1 | S1679 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4D2 | DAGLA | S847 | ochoa | Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:23502535, PubMed:26668358). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:23502535, PubMed:26668358). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). {ECO:0000250|UniProtKB:Q6WQJ1, ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:26668358}. |
| Q9Y4I1 | MYO5A | S1115 | ochoa | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin) | Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (PubMed:10448864). Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane (By similarity). May also be required for some polarization process involved in dendrite formation (By similarity). {ECO:0000250|UniProtKB:Q99104, ECO:0000250|UniProtKB:Q9QYF3, ECO:0000269|PubMed:10448864}. |
| Q9Y623 | MYH4 | S1726 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6A5 | TACC3 | S497 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9Y6D6 | ARFGEF1 | S234 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| P27986 | PIK3R1 | S155 | Sugiyama | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}. |
| P62979 | RPS27A | S123 | Sugiyama | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| Q08378 | GOLGA3 | S924 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q9BQS8 | FYCO1 | S669 | Sugiyama | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
| O15111 | CHUK | S361 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| O15146 | MUSK | S752 | Sugiyama | Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) | Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:25537362}. |
| Q14152 | EIF3A | Y697 | Sugiyama | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q8NFI4 | ST13P5 | S181 | Sugiyama | Putative protein FAM10A5 (Suppression of tumorigenicity 13 pseudogene 5) | None |
| O43283 | MAP3K13 | S901 | Sugiyama | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| Q9H4I2 | ZHX3 | S658 | Sugiyama | Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) | Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
| Q96E11 | MRRF | S239 | Sugiyama | Ribosome-recycling factor, mitochondrial (RRF) (mtRRF) (Ribosome-releasing factor, mitochondrial) | Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with GFM2 (PubMed:33878294). Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts (PubMed:33878294). {ECO:0000269|PubMed:19716793, ECO:0000269|PubMed:33878294}. |
| Q8IYE1 | CCDC13 | S680 | Sugiyama | Coiled-coil domain-containing protein 13 | Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia. {ECO:0000269|PubMed:24816561}. |
| Q02790 | FKBP4 | S224 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| P13688 | CEACAM1 | S472 | PSP | Cell adhesion molecule CEACAM1 (Biliary glycoprotein 1) (BGP-1) (Carcinoembryonic antigen-related cell adhesion molecule 1) (CEA cell adhesion molecule 1) (CD antigen CD66a) | [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R by down-regulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Down-regulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interferes with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809, ECO:0000269|PubMed:16291724, ECO:0000269|PubMed:18424730, ECO:0000269|PubMed:23696226, ECO:0000269|PubMed:25363763}.; FUNCTION: [Isoform 8]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809}. |
| P61201 | COPS2 | S178 | Sugiyama | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| P36888 | FLT3 | S838 | Sugiyama | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}. |
| P51451 | BLK | S387 | Sugiyama | Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) | Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Also phosphorylates the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Also contributes to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214). {ECO:0000250|UniProtKB:P16277, ECO:0000269|PubMed:19667185, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:8756631}. |
| P51813 | BMX | S568 | Sugiyama | Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}. |
| P51957 | NEK4 | S766 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P63104 | YWHAZ | T226 | Sugiyama | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| Q9BT78 | COPS4 | S298 | Sugiyama | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}. |
| Q01973 | ROR1 | S642 | Sugiyama | Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068). {ECO:0000269|PubMed:25029443, ECO:0000269|PubMed:27162350, ECO:0000269|PubMed:36949068}. |
| Q04759 | PRKCQ | S370 | Sugiyama | Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:21964608, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:8657160}. |
| P41208 | CETN2 | T45 | Sugiyama | Centrin-2 (Caltractin isoform 1) | Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269|PubMed:22307388, ECO:0000305|PubMed:23591820}. |
| P17980 | PSMC3 | S170 | Sugiyama | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| Q16620 | NTRK2 | S703 | Sugiyama | BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B) | Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:15494731, PubMed:7574684). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}. |
| Q6XUX3 | DSTYK | S65 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| Q96D15 | RCN3 | S119 | Sugiyama | Reticulocalbin-3 (EF-hand calcium-binding protein RLP49) | Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634). {ECO:0000250|UniProtKB:Q8BH97, ECO:0000269|PubMed:16433634, ECO:0000269|PubMed:28939891}. |
| Q9P2E9 | RRBP1 | S1321 | Sugiyama | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9646399 | Aggrephagy | 2.154442e-09 | 8.667 |
| R-HSA-69275 | G2/M Transition | 2.953685e-09 | 8.530 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.469904e-09 | 8.460 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.422594e-09 | 8.192 |
| R-HSA-9612973 | Autophagy | 7.664211e-09 | 8.116 |
| R-HSA-9663891 | Selective autophagy | 6.422594e-09 | 8.192 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.094531e-08 | 7.961 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.094531e-08 | 7.961 |
| R-HSA-1640170 | Cell Cycle | 4.119558e-08 | 7.385 |
| R-HSA-1632852 | Macroautophagy | 7.017597e-08 | 7.154 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.580820e-08 | 7.120 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.183608e-07 | 6.927 |
| R-HSA-68877 | Mitotic Prometaphase | 1.430778e-07 | 6.844 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.476814e-07 | 6.606 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 3.327902e-07 | 6.478 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 5.780192e-07 | 6.238 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 6.191586e-07 | 6.208 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 9.137668e-07 | 6.039 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.090972e-06 | 5.962 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.181014e-06 | 5.928 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.671230e-06 | 5.777 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.914051e-06 | 5.718 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.153993e-06 | 5.667 |
| R-HSA-68886 | M Phase | 2.660336e-06 | 5.575 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.756562e-06 | 5.425 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.315971e-06 | 5.365 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.837383e-06 | 5.315 |
| R-HSA-983189 | Kinesins | 6.639884e-06 | 5.178 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 9.331887e-06 | 5.030 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 9.331887e-06 | 5.030 |
| R-HSA-5617833 | Cilium Assembly | 1.158620e-05 | 4.936 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.290633e-05 | 4.889 |
| R-HSA-190861 | Gap junction assembly | 1.433376e-05 | 4.844 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.713702e-05 | 4.766 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.051608e-05 | 4.688 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.123971e-05 | 4.673 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.601888e-05 | 4.585 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.622731e-05 | 4.581 |
| R-HSA-380287 | Centrosome maturation | 3.138300e-05 | 4.503 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.992350e-05 | 4.399 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.117065e-05 | 4.385 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.642660e-05 | 4.333 |
| R-HSA-9833482 | PKR-mediated signaling | 4.903706e-05 | 4.309 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.642695e-05 | 4.249 |
| R-HSA-199991 | Membrane Trafficking | 6.476621e-05 | 4.189 |
| R-HSA-190828 | Gap junction trafficking | 6.365847e-05 | 4.196 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 8.079661e-05 | 4.093 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.498373e-05 | 4.071 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 8.993741e-05 | 4.046 |
| R-HSA-437239 | Recycling pathway of L1 | 8.993741e-05 | 4.046 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.119214e-04 | 3.951 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.186880e-04 | 3.926 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.425581e-04 | 3.846 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.425581e-04 | 3.846 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.370818e-04 | 3.863 |
| R-HSA-68882 | Mitotic Anaphase | 1.666045e-04 | 3.778 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.738944e-04 | 3.760 |
| R-HSA-9675108 | Nervous system development | 1.854920e-04 | 3.732 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.052938e-04 | 3.688 |
| R-HSA-9842663 | Signaling by LTK | 2.518858e-04 | 3.599 |
| R-HSA-109582 | Hemostasis | 2.653737e-04 | 3.576 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.743509e-04 | 3.562 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.813169e-04 | 3.551 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.817956e-04 | 3.550 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.064495e-04 | 3.514 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.240440e-04 | 3.489 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.678687e-04 | 3.434 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.226610e-04 | 3.374 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 4.833919e-04 | 3.316 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.288790e-04 | 3.277 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.981098e-04 | 3.303 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.981098e-04 | 3.303 |
| R-HSA-5620924 | Intraflagellar transport | 7.018477e-04 | 3.154 |
| R-HSA-391251 | Protein folding | 7.359178e-04 | 3.133 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 8.253637e-04 | 3.083 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 8.253637e-04 | 3.083 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.075509e-04 | 3.042 |
| R-HSA-187015 | Activation of TRKA receptors | 9.207944e-04 | 3.036 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 9.718172e-04 | 3.012 |
| R-HSA-3371556 | Cellular response to heat stress | 1.089763e-03 | 2.963 |
| R-HSA-422475 | Axon guidance | 1.038290e-03 | 2.984 |
| R-HSA-5205647 | Mitophagy | 1.109893e-03 | 2.955 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.173219e-03 | 2.931 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.205053e-03 | 2.919 |
| R-HSA-3371511 | HSF1 activation | 1.366841e-03 | 2.864 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.400387e-03 | 2.854 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.404091e-03 | 2.853 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.548277e-03 | 2.810 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.739610e-03 | 2.760 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 1.741973e-03 | 2.759 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.201307e-03 | 2.657 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.687850e-03 | 2.571 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.617390e-03 | 2.582 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.750907e-03 | 2.561 |
| R-HSA-5654743 | Signaling by FGFR4 | 2.847093e-03 | 2.546 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 2.902903e-03 | 2.537 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.029537e-03 | 2.519 |
| R-HSA-373760 | L1CAM interactions | 3.298933e-03 | 2.482 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.349685e-03 | 2.475 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 3.475476e-03 | 2.459 |
| R-HSA-187042 | TRKA activation by NGF | 4.040022e-03 | 2.394 |
| R-HSA-167021 | PLC-gamma1 signalling | 4.040022e-03 | 2.394 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 4.040022e-03 | 2.394 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.384034e-03 | 2.358 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.384034e-03 | 2.358 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 4.384034e-03 | 2.358 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.837063e-03 | 2.315 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 4.837063e-03 | 2.315 |
| R-HSA-3371571 | HSF1-dependent transactivation | 5.238178e-03 | 2.281 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 5.747121e-03 | 2.241 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 6.382111e-03 | 2.195 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.835233e-03 | 2.234 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.488147e-03 | 2.188 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 6.961970e-03 | 2.157 |
| R-HSA-5654736 | Signaling by FGFR1 | 7.305539e-03 | 2.136 |
| R-HSA-177929 | Signaling by EGFR | 7.305539e-03 | 2.136 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 7.575616e-03 | 2.121 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 7.727803e-03 | 2.112 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 7.727803e-03 | 2.112 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 7.727803e-03 | 2.112 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.973364e-03 | 2.098 |
| R-HSA-9682385 | FLT3 signaling in disease | 8.907368e-03 | 2.050 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 8.223830e-03 | 2.085 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 8.223830e-03 | 2.085 |
| R-HSA-913531 | Interferon Signaling | 9.367106e-03 | 2.028 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.542384e-03 | 2.020 |
| R-HSA-187024 | NGF-independant TRKA activation | 9.971494e-03 | 2.001 |
| R-HSA-5357801 | Programmed Cell Death | 1.021032e-02 | 1.991 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.021693e-02 | 1.991 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.038330e-02 | 1.984 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.052573e-02 | 1.978 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 1.200890e-02 | 1.920 |
| R-HSA-3371568 | Attenuation phase | 1.200890e-02 | 1.920 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.200890e-02 | 1.920 |
| R-HSA-2428924 | IGF1R signaling cascade | 1.169803e-02 | 1.932 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.086802e-02 | 1.964 |
| R-HSA-373753 | Nephrin family interactions | 1.173773e-02 | 1.930 |
| R-HSA-373755 | Semaphorin interactions | 1.106989e-02 | 1.956 |
| R-HSA-201556 | Signaling by ALK | 1.117706e-02 | 1.952 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 1.234998e-02 | 1.908 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.244941e-02 | 1.905 |
| R-HSA-166520 | Signaling by NTRKs | 1.329757e-02 | 1.876 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.378920e-02 | 1.860 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.473882e-02 | 1.832 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.520706e-02 | 1.818 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.560210e-02 | 1.807 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.572880e-02 | 1.803 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.583833e-02 | 1.800 |
| R-HSA-162582 | Signal Transduction | 1.594057e-02 | 1.797 |
| R-HSA-9702506 | Drug resistance of FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702509 | FLT3 mutants bind TKIs | 1.839721e-02 | 1.735 |
| R-HSA-9702636 | tandutinib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702620 | quizartinib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702590 | gilteritinib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702569 | KW2449-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702600 | midostaurin-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702614 | ponatinib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702577 | semaxanib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702632 | sunitinib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9703009 | tamatinib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702605 | pexidartinib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702596 | lestaurtinib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702581 | crenolanib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702624 | sorafenib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9702998 | linifanib-resistant FLT3 mutants | 1.839721e-02 | 1.735 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.817923e-02 | 1.740 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.817923e-02 | 1.740 |
| R-HSA-9700645 | ALK mutants bind TKIs | 2.137497e-02 | 1.670 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 1.894577e-02 | 1.722 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.894577e-02 | 1.722 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.026017e-02 | 1.693 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.894577e-02 | 1.722 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.894577e-02 | 1.722 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.894577e-02 | 1.722 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.896452e-02 | 1.722 |
| R-HSA-190236 | Signaling by FGFR | 1.706558e-02 | 1.768 |
| R-HSA-69206 | G1/S Transition | 1.668450e-02 | 1.778 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 2.137497e-02 | 1.670 |
| R-HSA-75153 | Apoptotic execution phase | 1.894577e-02 | 1.722 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.206769e-02 | 1.656 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 2.240752e-02 | 1.650 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.314971e-02 | 1.635 |
| R-HSA-8939211 | ESR-mediated signaling | 2.328277e-02 | 1.633 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.424807e-02 | 1.615 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.424807e-02 | 1.615 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 2.478511e-02 | 1.606 |
| R-HSA-198203 | PI3K/AKT activation | 2.478511e-02 | 1.606 |
| R-HSA-5689877 | Josephin domain DUBs | 2.478511e-02 | 1.606 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 2.478511e-02 | 1.606 |
| R-HSA-73894 | DNA Repair | 2.690167e-02 | 1.570 |
| R-HSA-202403 | TCR signaling | 2.761197e-02 | 1.559 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.816696e-02 | 1.550 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 2.840073e-02 | 1.547 |
| R-HSA-210990 | PECAM1 interactions | 2.840073e-02 | 1.547 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 3.221318e-02 | 1.492 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 3.621405e-02 | 1.441 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 3.621405e-02 | 1.441 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.024492e-02 | 1.519 |
| R-HSA-2424491 | DAP12 signaling | 3.024492e-02 | 1.519 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.405444e-02 | 1.468 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 3.621405e-02 | 1.441 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 3.621405e-02 | 1.441 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 3.221318e-02 | 1.492 |
| R-HSA-5657560 | Hereditary fructose intolerance | 3.645708e-02 | 1.438 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.672114e-02 | 1.435 |
| R-HSA-202424 | Downstream TCR signaling | 3.873125e-02 | 1.412 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.910628e-02 | 1.408 |
| R-HSA-390522 | Striated Muscle Contraction | 3.933868e-02 | 1.405 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.933868e-02 | 1.405 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.933868e-02 | 1.405 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 4.180516e-02 | 1.379 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.270178e-02 | 1.370 |
| R-HSA-162906 | HIV Infection | 4.308972e-02 | 1.366 |
| R-HSA-9027284 | Erythropoietin activates RAS | 4.926652e-02 | 1.307 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 4.926652e-02 | 1.307 |
| R-HSA-9706369 | Negative regulation of FLT3 | 5.394162e-02 | 1.268 |
| R-HSA-5656121 | Translesion synthesis by POLI | 5.394162e-02 | 1.268 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.843058e-02 | 1.315 |
| R-HSA-110312 | Translesion synthesis by REV1 | 4.926652e-02 | 1.307 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 4.926652e-02 | 1.307 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.965783e-02 | 1.304 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 5.394162e-02 | 1.268 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.434766e-02 | 1.353 |
| R-HSA-187687 | Signalling to ERKs | 4.434766e-02 | 1.353 |
| R-HSA-169893 | Prolonged ERK activation events | 5.394162e-02 | 1.268 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 4.474854e-02 | 1.349 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 4.474854e-02 | 1.349 |
| R-HSA-8853659 | RET signaling | 4.696546e-02 | 1.328 |
| R-HSA-69481 | G2/M Checkpoints | 5.098287e-02 | 1.293 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.239375e-02 | 1.281 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 4.926652e-02 | 1.307 |
| R-HSA-9609690 | HCMV Early Events | 4.947149e-02 | 1.306 |
| R-HSA-114608 | Platelet degranulation | 5.098287e-02 | 1.293 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.488301e-02 | 1.348 |
| R-HSA-2262752 | Cellular responses to stress | 5.013980e-02 | 1.300 |
| R-HSA-109581 | Apoptosis | 5.278681e-02 | 1.277 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.525859e-02 | 1.344 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 5.418576e-02 | 1.266 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 5.418576e-02 | 1.266 |
| R-HSA-5218859 | Regulated Necrosis | 5.456302e-02 | 1.263 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 7.158932e-02 | 1.145 |
| R-HSA-9026357 | NTF4 activates NTRK2 (TRKB) signaling | 7.158932e-02 | 1.145 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 7.158932e-02 | 1.145 |
| R-HSA-9025046 | NTF3 activates NTRK2 (TRKB) signaling | 7.158932e-02 | 1.145 |
| R-HSA-9024909 | BDNF activates NTRK2 (TRKB) signaling | 7.158932e-02 | 1.145 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 7.158932e-02 | 1.145 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 7.158932e-02 | 1.145 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 7.158932e-02 | 1.145 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 7.158932e-02 | 1.145 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 7.158932e-02 | 1.145 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 7.158932e-02 | 1.145 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 7.158932e-02 | 1.145 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 7.158932e-02 | 1.145 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 7.158932e-02 | 1.145 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 7.158932e-02 | 1.145 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 7.158932e-02 | 1.145 |
| R-HSA-5655862 | Translesion synthesis by POLK | 5.876655e-02 | 1.231 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.817397e-02 | 1.235 |
| R-HSA-9607240 | FLT3 Signaling | 6.115605e-02 | 1.214 |
| R-HSA-110320 | Translesion Synthesis by POLH | 7.407086e-02 | 1.130 |
| R-HSA-5674135 | MAP2K and MAPK activation | 6.420822e-02 | 1.192 |
| R-HSA-5689603 | UCH proteinases | 7.285758e-02 | 1.138 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.285758e-02 | 1.138 |
| R-HSA-5688426 | Deubiquitination | 7.351677e-02 | 1.134 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.109559e-02 | 1.214 |
| R-HSA-6811438 | Intra-Golgi traffic | 6.420822e-02 | 1.192 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.744025e-02 | 1.241 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 6.373426e-02 | 1.196 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 7.407086e-02 | 1.130 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 6.115605e-02 | 1.214 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 6.420822e-02 | 1.192 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 7.158932e-02 | 1.145 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 7.051874e-02 | 1.152 |
| R-HSA-392517 | Rap1 signalling | 7.407086e-02 | 1.130 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 5.876655e-02 | 1.231 |
| R-HSA-2172127 | DAP12 interactions | 7.377498e-02 | 1.132 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.802310e-02 | 1.167 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.041891e-02 | 1.152 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.887389e-02 | 1.230 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.802310e-02 | 1.167 |
| R-HSA-397014 | Muscle contraction | 7.016552e-02 | 1.154 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.336118e-02 | 1.198 |
| R-HSA-1280218 | Adaptive Immune System | 6.483841e-02 | 1.188 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.016552e-02 | 1.154 |
| R-HSA-69231 | Cyclin D associated events in G1 | 7.377498e-02 | 1.132 |
| R-HSA-69236 | G1 Phase | 7.377498e-02 | 1.132 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.081395e-02 | 1.150 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.780653e-02 | 1.169 |
| R-HSA-210993 | Tie2 Signaling | 6.883792e-02 | 1.162 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.135634e-02 | 1.212 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.946875e-02 | 1.226 |
| R-HSA-373752 | Netrin-1 signaling | 7.377498e-02 | 1.132 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.484259e-02 | 1.126 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.640343e-02 | 1.117 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 7.709706e-02 | 1.113 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 7.709706e-02 | 1.113 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.761422e-02 | 1.110 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.786225e-02 | 1.109 |
| R-HSA-4086400 | PCP/CE pathway | 7.786225e-02 | 1.109 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 7.942666e-02 | 1.100 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.000764e-02 | 1.097 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 8.048387e-02 | 1.094 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 8.048387e-02 | 1.094 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 8.489904e-02 | 1.071 |
| R-HSA-167044 | Signalling to RAS | 8.489904e-02 | 1.071 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.513534e-02 | 1.070 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 8.568256e-02 | 1.067 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 8.867369e-02 | 1.052 |
| R-HSA-198745 | Signalling to STAT3 | 8.867369e-02 | 1.052 |
| R-HSA-8941237 | Invadopodia formation | 8.867369e-02 | 1.052 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 1.054447e-01 | 0.977 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 1.054447e-01 | 0.977 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 1.054447e-01 | 0.977 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 1.219081e-01 | 0.914 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 1.219081e-01 | 0.914 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 1.219081e-01 | 0.914 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.380695e-01 | 0.860 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 1.380695e-01 | 0.860 |
| R-HSA-5340588 | Signaling by RNF43 mutants | 1.380695e-01 | 0.860 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.539344e-01 | 0.813 |
| R-HSA-3656244 | Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | 1.539344e-01 | 0.813 |
| R-HSA-9645135 | STAT5 Activation | 1.539344e-01 | 0.813 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.539344e-01 | 0.813 |
| R-HSA-3656243 | Defective ST3GAL3 causes MCT12 and EIEE15 | 1.539344e-01 | 0.813 |
| R-HSA-3656225 | Defective CHST6 causes MCDC1 | 1.539344e-01 | 0.813 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.695083e-01 | 0.771 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 1.695083e-01 | 0.771 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.695083e-01 | 0.771 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.847965e-01 | 0.733 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.847965e-01 | 0.733 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.847965e-01 | 0.733 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.847965e-01 | 0.733 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.847965e-01 | 0.733 |
| R-HSA-170984 | ARMS-mediated activation | 1.998041e-01 | 0.699 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 2.145363e-01 | 0.668 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 9.048194e-02 | 1.043 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 9.048194e-02 | 1.043 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 1.019559e-01 | 0.992 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 1.078358e-01 | 0.967 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 2.431948e-01 | 0.614 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 2.571307e-01 | 0.590 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.571307e-01 | 0.590 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.259829e-01 | 0.900 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 1.259829e-01 | 0.900 |
| R-HSA-167287 | HIV elongation arrest and recovery | 1.321843e-01 | 0.879 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 1.321843e-01 | 0.879 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 1.384539e-01 | 0.859 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.384539e-01 | 0.859 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.511793e-01 | 0.821 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 8.744700e-02 | 1.058 |
| R-HSA-72187 | mRNA 3'-end processing | 1.020977e-01 | 0.991 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.020977e-01 | 0.991 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.020977e-01 | 0.991 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.059041e-01 | 0.975 |
| R-HSA-5696400 | Dual Incision in GG-NER | 1.772560e-01 | 0.751 |
| R-HSA-72649 | Translation initiation complex formation | 1.097654e-01 | 0.960 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.176479e-01 | 0.929 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.176479e-01 | 0.929 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.257347e-01 | 0.901 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 8.837141e-02 | 1.054 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.107059e-01 | 0.676 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 9.952660e-02 | 1.002 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 9.952660e-02 | 1.002 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.174747e-01 | 0.663 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.583830e-01 | 0.588 |
| R-HSA-774815 | Nucleosome assembly | 2.583830e-01 | 0.588 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.918439e-01 | 0.717 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.242624e-01 | 0.649 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.499296e-01 | 0.824 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 1.852361e-01 | 0.732 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 2.145363e-01 | 0.668 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.078358e-01 | 0.967 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.198544e-01 | 0.921 |
| R-HSA-354192 | Integrin signaling | 1.641243e-01 | 0.785 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.952480e-01 | 0.709 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 9.616948e-02 | 1.017 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 9.667869e-02 | 1.015 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.998041e-01 | 0.699 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 9.465487e-02 | 1.024 |
| R-HSA-6798695 | Neutrophil degranulation | 1.120657e-01 | 0.951 |
| R-HSA-167172 | Transcription of the HIV genome | 1.688678e-01 | 0.772 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.236621e-01 | 0.908 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.022953e-01 | 0.694 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.847965e-01 | 0.733 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.998041e-01 | 0.699 |
| R-HSA-162588 | Budding and maturation of HIV virion | 1.511793e-01 | 0.821 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.020977e-01 | 0.991 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.059041e-01 | 0.975 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 1.905438e-01 | 0.720 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.583830e-01 | 0.588 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.772560e-01 | 0.751 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.965313e-01 | 0.707 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.447870e-01 | 0.839 |
| R-HSA-5673000 | RAF activation | 1.772560e-01 | 0.751 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.838822e-01 | 0.735 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.838822e-01 | 0.735 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.310660e-01 | 0.636 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 2.571307e-01 | 0.590 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.198544e-01 | 0.921 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.380695e-01 | 0.860 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 2.289982e-01 | 0.640 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.918439e-01 | 0.717 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 1.078358e-01 | 0.967 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.871855e-01 | 0.728 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.539344e-01 | 0.813 |
| R-HSA-525793 | Myogenesis | 1.198544e-01 | 0.921 |
| R-HSA-4641258 | Degradation of DVL | 1.972372e-01 | 0.705 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.534514e-01 | 0.814 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 9.048194e-02 | 1.043 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.447093e-01 | 0.611 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 8.867369e-02 | 1.052 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 1.054447e-01 | 0.977 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 1.380695e-01 | 0.860 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.380695e-01 | 0.860 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.695083e-01 | 0.771 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 1.847965e-01 | 0.733 |
| R-HSA-9927354 | Co-stimulation by ICOS | 1.847965e-01 | 0.733 |
| R-HSA-192905 | vRNP Assembly | 2.289982e-01 | 0.640 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 2.571307e-01 | 0.590 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.447870e-01 | 0.839 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 9.834754e-02 | 1.007 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.905438e-01 | 0.720 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.905438e-01 | 0.720 |
| R-HSA-4641257 | Degradation of AXIN | 1.972372e-01 | 0.705 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.972372e-01 | 0.705 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.382253e-01 | 0.859 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.174747e-01 | 0.663 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.310660e-01 | 0.636 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.242624e-01 | 0.649 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.174747e-01 | 0.663 |
| R-HSA-75893 | TNF signaling | 1.176479e-01 | 0.929 |
| R-HSA-74749 | Signal attenuation | 2.145363e-01 | 0.668 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.107059e-01 | 0.676 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 1.695083e-01 | 0.771 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.695083e-01 | 0.771 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.847965e-01 | 0.733 |
| R-HSA-9762292 | Regulation of CDH11 function | 2.145363e-01 | 0.668 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.289982e-01 | 0.640 |
| R-HSA-8851805 | MET activates RAS signaling | 2.571307e-01 | 0.590 |
| R-HSA-9766229 | Degradation of CDH1 | 9.102095e-02 | 1.041 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.706688e-01 | 0.768 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.772560e-01 | 0.751 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.772560e-01 | 0.751 |
| R-HSA-169911 | Regulation of Apoptosis | 1.838822e-01 | 0.735 |
| R-HSA-74751 | Insulin receptor signalling cascade | 1.511168e-01 | 0.821 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.310660e-01 | 0.636 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.310660e-01 | 0.636 |
| R-HSA-162587 | HIV Life Cycle | 1.099932e-01 | 0.959 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.432343e-01 | 0.844 |
| R-HSA-69306 | DNA Replication | 2.141878e-01 | 0.669 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 8.744700e-02 | 1.058 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.583830e-01 | 0.588 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.893418e-01 | 0.723 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.604118e-01 | 0.795 |
| R-HSA-8983432 | Interleukin-15 signaling | 2.571307e-01 | 0.590 |
| R-HSA-9669938 | Signaling by KIT in disease | 9.616948e-02 | 1.017 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.310660e-01 | 0.636 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 9.446795e-02 | 1.025 |
| R-HSA-6807070 | PTEN Regulation | 1.667994e-01 | 0.778 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.380695e-01 | 0.860 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 1.380695e-01 | 0.860 |
| R-HSA-426048 | Arachidonate production from DAG | 2.145363e-01 | 0.668 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 2.145363e-01 | 0.668 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 2.571307e-01 | 0.590 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 2.571307e-01 | 0.590 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.257347e-01 | 0.901 |
| R-HSA-167169 | HIV Transcription Elongation | 2.174747e-01 | 0.663 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.174747e-01 | 0.663 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.242624e-01 | 0.649 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.242624e-01 | 0.649 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.779610e-01 | 0.750 |
| R-HSA-69239 | Synthesis of DNA | 1.819557e-01 | 0.740 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.082082e-01 | 0.682 |
| R-HSA-182971 | EGFR downregulation | 1.511793e-01 | 0.821 |
| R-HSA-194138 | Signaling by VEGF | 1.216413e-01 | 0.915 |
| R-HSA-186763 | Downstream signal transduction | 1.511793e-01 | 0.821 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.059041e-01 | 0.975 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.382253e-01 | 0.859 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.145363e-01 | 0.668 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.107059e-01 | 0.676 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.576264e-01 | 0.802 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.674858e-01 | 0.776 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 1.259829e-01 | 0.900 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.641243e-01 | 0.785 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.972372e-01 | 0.705 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.447093e-01 | 0.611 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.515436e-01 | 0.599 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.583830e-01 | 0.588 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.772560e-01 | 0.751 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.164514e-01 | 0.934 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.078358e-01 | 0.967 |
| R-HSA-69242 | S Phase | 9.138218e-02 | 1.039 |
| R-HSA-5693538 | Homology Directed Repair | 2.315163e-01 | 0.635 |
| R-HSA-69541 | Stabilization of p53 | 2.107059e-01 | 0.676 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.121730e-01 | 0.950 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.539344e-01 | 0.813 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.695083e-01 | 0.771 |
| R-HSA-209560 | NF-kB is activated and signals survival | 2.431948e-01 | 0.614 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.431948e-01 | 0.614 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.571307e-01 | 0.590 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.398236e-01 | 0.620 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.354719e-01 | 0.868 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.082082e-01 | 0.682 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.905438e-01 | 0.720 |
| R-HSA-451927 | Interleukin-2 family signaling | 2.174747e-01 | 0.663 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.138037e-01 | 0.944 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.515436e-01 | 0.599 |
| R-HSA-168249 | Innate Immune System | 2.324845e-01 | 0.634 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.695083e-01 | 0.771 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.176479e-01 | 0.929 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.215621e-01 | 0.655 |
| R-HSA-9694493 | Maturation of protein E | 1.380695e-01 | 0.860 |
| R-HSA-9683683 | Maturation of protein E | 1.380695e-01 | 0.860 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.380695e-01 | 0.860 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.380695e-01 | 0.860 |
| R-HSA-8964011 | HDL clearance | 1.539344e-01 | 0.813 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.847965e-01 | 0.733 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.998041e-01 | 0.699 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 2.145363e-01 | 0.668 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 9.616948e-02 | 1.017 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.289982e-01 | 0.640 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 2.289982e-01 | 0.640 |
| R-HSA-9634597 | GPER1 signaling | 8.744700e-02 | 1.058 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.107059e-01 | 0.676 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.447349e-01 | 0.611 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.511168e-01 | 0.821 |
| R-HSA-168256 | Immune System | 1.932879e-01 | 0.714 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.332994e-01 | 0.875 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.583830e-01 | 0.588 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.583830e-01 | 0.588 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.583830e-01 | 0.588 |
| R-HSA-6806834 | Signaling by MET | 2.251969e-01 | 0.647 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.165984e-01 | 0.933 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 2.583830e-01 | 0.588 |
| R-HSA-446728 | Cell junction organization | 1.929220e-01 | 0.715 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.380695e-01 | 0.860 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 1.847965e-01 | 0.733 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.998041e-01 | 0.699 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.499296e-01 | 0.824 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.499296e-01 | 0.824 |
| R-HSA-1500931 | Cell-Cell communication | 9.909971e-02 | 1.004 |
| R-HSA-9609646 | HCMV Infection | 1.330002e-01 | 0.876 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.779610e-01 | 0.750 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.856367e-01 | 0.731 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.125757e-01 | 0.672 |
| R-HSA-9664873 | Pexophagy | 2.145363e-01 | 0.668 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.965313e-01 | 0.707 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.790085e-01 | 0.747 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.698200e-01 | 0.770 |
| R-HSA-9664407 | Parasite infection | 1.698200e-01 | 0.770 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.698200e-01 | 0.770 |
| R-HSA-9635465 | Suppression of apoptosis | 2.289982e-01 | 0.640 |
| R-HSA-8854214 | TBC/RABGAPs | 2.447093e-01 | 0.611 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.825575e-01 | 0.739 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.315163e-01 | 0.635 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.449297e-01 | 0.839 |
| R-HSA-74160 | Gene expression (Transcription) | 1.260807e-01 | 0.899 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 2.039112e-01 | 0.691 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.811724e-01 | 0.742 |
| R-HSA-9824446 | Viral Infection Pathways | 1.722694e-01 | 0.764 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 1.695083e-01 | 0.771 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.847965e-01 | 0.733 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.972372e-01 | 0.705 |
| R-HSA-983712 | Ion channel transport | 1.925918e-01 | 0.715 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.871855e-01 | 0.728 |
| R-HSA-9909396 | Circadian clock | 1.434435e-01 | 0.843 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 2.289982e-01 | 0.640 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.571307e-01 | 0.590 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.571307e-01 | 0.590 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 1.772560e-01 | 0.751 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.786001e-01 | 0.748 |
| R-HSA-9020558 | Interleukin-2 signaling | 2.289982e-01 | 0.640 |
| R-HSA-212436 | Generic Transcription Pathway | 1.992128e-01 | 0.701 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.847965e-01 | 0.733 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.998041e-01 | 0.699 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 9.048194e-02 | 1.043 |
| R-HSA-449147 | Signaling by Interleukins | 1.507410e-01 | 0.822 |
| R-HSA-9648002 | RAS processing | 2.107059e-01 | 0.676 |
| R-HSA-1483255 | PI Metabolism | 1.604118e-01 | 0.795 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.641243e-01 | 0.785 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.251969e-01 | 0.647 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.905438e-01 | 0.720 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 2.434049e-01 | 0.614 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.550108e-01 | 0.810 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.066720e-02 | 1.043 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.772560e-01 | 0.751 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.500623e-01 | 0.602 |
| R-HSA-9694301 | Maturation of replicase proteins | 1.695083e-01 | 0.771 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.107059e-01 | 0.676 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 2.289982e-01 | 0.640 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.024132e-01 | 0.990 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.205183e-01 | 0.919 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.107059e-01 | 0.676 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.595604e-01 | 0.586 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.595604e-01 | 0.586 |
| R-HSA-597592 | Post-translational protein modification | 2.608980e-01 | 0.584 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.652248e-01 | 0.576 |
| R-HSA-156902 | Peptide chain elongation | 2.695095e-01 | 0.569 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.708109e-01 | 0.567 |
| R-HSA-170968 | Frs2-mediated activation | 2.708109e-01 | 0.567 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 2.708109e-01 | 0.567 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.708109e-01 | 0.567 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 2.708109e-01 | 0.567 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 2.708109e-01 | 0.567 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.720667e-01 | 0.565 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.720667e-01 | 0.565 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.745005e-01 | 0.561 |
| R-HSA-9679506 | SARS-CoV Infections | 2.759014e-01 | 0.559 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.789064e-01 | 0.555 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.793008e-01 | 0.554 |
| R-HSA-418990 | Adherens junctions interactions | 2.825906e-01 | 0.549 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 2.842400e-01 | 0.546 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 2.842400e-01 | 0.546 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.842400e-01 | 0.546 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.842400e-01 | 0.546 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 2.842400e-01 | 0.546 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 2.842400e-01 | 0.546 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.842400e-01 | 0.546 |
| R-HSA-5578768 | Physiological factors | 2.842400e-01 | 0.546 |
| R-HSA-435354 | Zinc transporters | 2.842400e-01 | 0.546 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.842400e-01 | 0.546 |
| R-HSA-73893 | DNA Damage Bypass | 2.857416e-01 | 0.544 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.857416e-01 | 0.544 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.857416e-01 | 0.544 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 2.925703e-01 | 0.534 |
| R-HSA-109704 | PI3K Cascade | 2.925703e-01 | 0.534 |
| R-HSA-1643685 | Disease | 2.936654e-01 | 0.532 |
| R-HSA-74752 | Signaling by Insulin receptor | 2.945499e-01 | 0.531 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.974226e-01 | 0.527 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 2.974226e-01 | 0.527 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.974226e-01 | 0.527 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.974226e-01 | 0.527 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.974226e-01 | 0.527 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.974226e-01 | 0.527 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.974226e-01 | 0.527 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2.974226e-01 | 0.527 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 2.974226e-01 | 0.527 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 2.974226e-01 | 0.527 |
| R-HSA-8876725 | Protein methylation | 2.974226e-01 | 0.527 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.974226e-01 | 0.527 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.974226e-01 | 0.527 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 2.974226e-01 | 0.527 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.974226e-01 | 0.527 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.974226e-01 | 0.527 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.974226e-01 | 0.527 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.974226e-01 | 0.527 |
| R-HSA-5663205 | Infectious disease | 2.991385e-01 | 0.524 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.993903e-01 | 0.524 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.993903e-01 | 0.524 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.995786e-01 | 0.523 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 2.995786e-01 | 0.523 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 3.046120e-01 | 0.516 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.061997e-01 | 0.514 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.061997e-01 | 0.514 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.061997e-01 | 0.514 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.061997e-01 | 0.514 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.061997e-01 | 0.514 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.071703e-01 | 0.513 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 3.103632e-01 | 0.508 |
| R-HSA-70350 | Fructose catabolism | 3.103632e-01 | 0.508 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 3.103632e-01 | 0.508 |
| R-HSA-9708530 | Regulation of BACH1 activity | 3.103632e-01 | 0.508 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 3.103632e-01 | 0.508 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.129965e-01 | 0.504 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.129965e-01 | 0.504 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.129965e-01 | 0.504 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.129965e-01 | 0.504 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.146888e-01 | 0.502 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.170027e-01 | 0.499 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 3.197304e-01 | 0.495 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.197304e-01 | 0.495 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.197789e-01 | 0.495 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.197789e-01 | 0.495 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.222852e-01 | 0.492 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 3.230662e-01 | 0.491 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 3.230662e-01 | 0.491 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 3.230662e-01 | 0.491 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 3.230662e-01 | 0.491 |
| R-HSA-432047 | Passive transport by Aquaporins | 3.230662e-01 | 0.491 |
| R-HSA-1566977 | Fibronectin matrix formation | 3.230662e-01 | 0.491 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 3.230662e-01 | 0.491 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.247730e-01 | 0.488 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.265451e-01 | 0.486 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.265451e-01 | 0.486 |
| R-HSA-9658195 | Leishmania infection | 3.273723e-01 | 0.485 |
| R-HSA-9824443 | Parasitic Infection Pathways | 3.273723e-01 | 0.485 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.295022e-01 | 0.482 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.332935e-01 | 0.477 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.332935e-01 | 0.477 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 3.355360e-01 | 0.474 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.355360e-01 | 0.474 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 3.355360e-01 | 0.474 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.355360e-01 | 0.474 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.355360e-01 | 0.474 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 3.355360e-01 | 0.474 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.355360e-01 | 0.474 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.355360e-01 | 0.474 |
| R-HSA-2028269 | Signaling by Hippo | 3.355360e-01 | 0.474 |
| R-HSA-3229121 | Glycogen storage diseases | 3.355360e-01 | 0.474 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 3.355360e-01 | 0.474 |
| R-HSA-112399 | IRS-mediated signalling | 3.400225e-01 | 0.468 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.449353e-01 | 0.462 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.467303e-01 | 0.460 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.477769e-01 | 0.459 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.477769e-01 | 0.459 |
| R-HSA-180292 | GAB1 signalosome | 3.477769e-01 | 0.459 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.477769e-01 | 0.459 |
| R-HSA-5358508 | Mismatch Repair | 3.477769e-01 | 0.459 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.477769e-01 | 0.459 |
| R-HSA-9033241 | Peroxisomal protein import | 3.534156e-01 | 0.452 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.534156e-01 | 0.452 |
| R-HSA-191859 | snRNP Assembly | 3.534156e-01 | 0.452 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 3.597930e-01 | 0.444 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.597930e-01 | 0.444 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 3.597930e-01 | 0.444 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.597930e-01 | 0.444 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 3.597930e-01 | 0.444 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 3.597930e-01 | 0.444 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.600256e-01 | 0.444 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.600770e-01 | 0.444 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 3.600770e-01 | 0.444 |
| R-HSA-379724 | tRNA Aminoacylation | 3.600770e-01 | 0.444 |
| R-HSA-450294 | MAP kinase activation | 3.667129e-01 | 0.436 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.667129e-01 | 0.436 |
| R-HSA-1483257 | Phospholipid metabolism | 3.691985e-01 | 0.433 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.700589e-01 | 0.432 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 3.715884e-01 | 0.430 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 3.715884e-01 | 0.430 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 3.715884e-01 | 0.430 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 3.715884e-01 | 0.430 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 3.715884e-01 | 0.430 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.715884e-01 | 0.430 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 3.715884e-01 | 0.430 |
| R-HSA-2022857 | Keratan sulfate degradation | 3.715884e-01 | 0.430 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.715884e-01 | 0.430 |
| R-HSA-3322077 | Glycogen synthesis | 3.715884e-01 | 0.430 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 3.715884e-01 | 0.430 |
| R-HSA-186797 | Signaling by PDGF | 3.733222e-01 | 0.428 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.733222e-01 | 0.428 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.796405e-01 | 0.421 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.796405e-01 | 0.421 |
| R-HSA-6799198 | Complex I biogenesis | 3.799035e-01 | 0.420 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.799035e-01 | 0.420 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.799035e-01 | 0.420 |
| R-HSA-211000 | Gene Silencing by RNA | 3.800636e-01 | 0.420 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.831672e-01 | 0.417 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.831672e-01 | 0.417 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.831672e-01 | 0.417 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.831672e-01 | 0.417 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 3.831672e-01 | 0.417 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 3.831672e-01 | 0.417 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 3.831672e-01 | 0.417 |
| R-HSA-2161541 | Abacavir metabolism | 3.831672e-01 | 0.417 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.850536e-01 | 0.414 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.850536e-01 | 0.414 |
| R-HSA-421270 | Cell-cell junction organization | 3.896835e-01 | 0.409 |
| R-HSA-9609507 | Protein localization | 3.921450e-01 | 0.407 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.929775e-01 | 0.406 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.929775e-01 | 0.406 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.945334e-01 | 0.404 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.945334e-01 | 0.404 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.945334e-01 | 0.404 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.945334e-01 | 0.404 |
| R-HSA-175474 | Assembly Of The HIV Virion | 3.945334e-01 | 0.404 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.945334e-01 | 0.404 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.945334e-01 | 0.404 |
| R-HSA-9755088 | Ribavirin ADME | 3.945334e-01 | 0.404 |
| R-HSA-947581 | Molybdenum cofactor biosynthesis | 3.945334e-01 | 0.404 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.950050e-01 | 0.403 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.950050e-01 | 0.403 |
| R-HSA-73887 | Death Receptor Signaling | 3.963056e-01 | 0.402 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.004618e-01 | 0.397 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 4.049143e-01 | 0.393 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 4.056909e-01 | 0.392 |
| R-HSA-6803529 | FGFR2 alternative splicing | 4.056909e-01 | 0.392 |
| R-HSA-5652084 | Fructose metabolism | 4.056909e-01 | 0.392 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 4.056909e-01 | 0.392 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 4.056909e-01 | 0.392 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.059259e-01 | 0.392 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.123504e-01 | 0.385 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.123504e-01 | 0.385 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 4.166434e-01 | 0.380 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 4.166434e-01 | 0.380 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 4.166434e-01 | 0.380 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 4.166434e-01 | 0.380 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.166434e-01 | 0.380 |
| R-HSA-3000170 | Syndecan interactions | 4.166434e-01 | 0.380 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.166434e-01 | 0.380 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 4.187405e-01 | 0.378 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.211612e-01 | 0.376 |
| R-HSA-1266738 | Developmental Biology | 4.243619e-01 | 0.372 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.250952e-01 | 0.372 |
| R-HSA-448424 | Interleukin-17 signaling | 4.250952e-01 | 0.372 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.250952e-01 | 0.372 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 4.273947e-01 | 0.369 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.273947e-01 | 0.369 |
| R-HSA-9865881 | Complex III assembly | 4.273947e-01 | 0.369 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 4.294696e-01 | 0.367 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.314138e-01 | 0.365 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.314138e-01 | 0.365 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.314138e-01 | 0.365 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.343387e-01 | 0.362 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.343387e-01 | 0.362 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.351048e-01 | 0.361 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 4.379485e-01 | 0.359 |
| R-HSA-9620244 | Long-term potentiation | 4.379485e-01 | 0.359 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.379485e-01 | 0.359 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.379485e-01 | 0.359 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 4.379485e-01 | 0.359 |
| R-HSA-3214842 | HDMs demethylate histones | 4.379485e-01 | 0.359 |
| R-HSA-1266695 | Interleukin-7 signaling | 4.379485e-01 | 0.359 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 4.379485e-01 | 0.359 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.391925e-01 | 0.357 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.391925e-01 | 0.357 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.439390e-01 | 0.353 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 4.439390e-01 | 0.353 |
| R-HSA-3295583 | TRP channels | 4.483084e-01 | 0.348 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4.483084e-01 | 0.348 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 4.483084e-01 | 0.348 |
| R-HSA-2161522 | Abacavir ADME | 4.483084e-01 | 0.348 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.488520e-01 | 0.348 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.501442e-01 | 0.347 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 4.501442e-01 | 0.347 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.533490e-01 | 0.344 |
| R-HSA-8852135 | Protein ubiquitination | 4.563101e-01 | 0.341 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.563101e-01 | 0.341 |
| R-HSA-72766 | Translation | 4.576540e-01 | 0.339 |
| R-HSA-73886 | Chromosome Maintenance | 4.584443e-01 | 0.339 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 4.584780e-01 | 0.339 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.584780e-01 | 0.339 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.584780e-01 | 0.339 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 4.584780e-01 | 0.339 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 4.584780e-01 | 0.339 |
| R-HSA-8949613 | Cristae formation | 4.584780e-01 | 0.339 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.584780e-01 | 0.339 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 4.584780e-01 | 0.339 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.584780e-01 | 0.339 |
| R-HSA-264876 | Insulin processing | 4.584780e-01 | 0.339 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.624362e-01 | 0.335 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.679654e-01 | 0.330 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.684608e-01 | 0.329 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 4.684608e-01 | 0.329 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.684608e-01 | 0.329 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 4.684608e-01 | 0.329 |
| R-HSA-622312 | Inflammasomes | 4.684608e-01 | 0.329 |
| R-HSA-5619084 | ABC transporter disorders | 4.745662e-01 | 0.324 |
| R-HSA-191273 | Cholesterol biosynthesis | 4.745662e-01 | 0.324 |
| R-HSA-1474244 | Extracellular matrix organization | 4.771033e-01 | 0.321 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.782602e-01 | 0.320 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.782602e-01 | 0.320 |
| R-HSA-72086 | mRNA Capping | 4.782602e-01 | 0.320 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.782602e-01 | 0.320 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.782602e-01 | 0.320 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 4.782602e-01 | 0.320 |
| R-HSA-9659379 | Sensory processing of sound | 4.805690e-01 | 0.318 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.805690e-01 | 0.318 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.865296e-01 | 0.313 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.878794e-01 | 0.312 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.878794e-01 | 0.312 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.878794e-01 | 0.312 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.878794e-01 | 0.312 |
| R-HSA-977225 | Amyloid fiber formation | 4.924476e-01 | 0.308 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.924476e-01 | 0.308 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.973219e-01 | 0.303 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.973219e-01 | 0.303 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.973219e-01 | 0.303 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.973219e-01 | 0.303 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.973219e-01 | 0.303 |
| R-HSA-5694530 | Cargo concentration in the ER | 4.973219e-01 | 0.303 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.973219e-01 | 0.303 |
| R-HSA-611105 | Respiratory electron transport | 4.978747e-01 | 0.303 |
| R-HSA-168255 | Influenza Infection | 5.017995e-01 | 0.299 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.052696e-01 | 0.296 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 5.064049e-01 | 0.296 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 5.065909e-01 | 0.295 |
| R-HSA-69190 | DNA strand elongation | 5.065909e-01 | 0.295 |
| R-HSA-4791275 | Signaling by WNT in cancer | 5.065909e-01 | 0.295 |
| R-HSA-1538133 | G0 and Early G1 | 5.065909e-01 | 0.295 |
| R-HSA-1500620 | Meiosis | 5.156844e-01 | 0.288 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.156844e-01 | 0.288 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 5.156895e-01 | 0.288 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 5.156895e-01 | 0.288 |
| R-HSA-2022854 | Keratan sulfate biosynthesis | 5.156895e-01 | 0.288 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.156895e-01 | 0.288 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.156895e-01 | 0.288 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 5.156895e-01 | 0.288 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 5.156895e-01 | 0.288 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 5.156895e-01 | 0.288 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.156895e-01 | 0.288 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 5.156895e-01 | 0.288 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.156895e-01 | 0.288 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 5.156895e-01 | 0.288 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.156895e-01 | 0.288 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.213829e-01 | 0.283 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.246209e-01 | 0.280 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 5.246209e-01 | 0.280 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 5.246209e-01 | 0.280 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 5.246209e-01 | 0.280 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 5.246209e-01 | 0.280 |
| R-HSA-189483 | Heme degradation | 5.246209e-01 | 0.280 |
| R-HSA-70268 | Pyruvate metabolism | 5.326450e-01 | 0.274 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.326450e-01 | 0.274 |
| R-HSA-203615 | eNOS activation | 5.333882e-01 | 0.273 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 5.333882e-01 | 0.273 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 5.333882e-01 | 0.273 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 5.333882e-01 | 0.273 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 5.333882e-01 | 0.273 |
| R-HSA-1980145 | Signaling by NOTCH2 | 5.333882e-01 | 0.273 |
| R-HSA-195721 | Signaling by WNT | 5.403527e-01 | 0.267 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.419942e-01 | 0.266 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 5.419942e-01 | 0.266 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.419942e-01 | 0.266 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.419942e-01 | 0.266 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.419942e-01 | 0.266 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.455676e-01 | 0.263 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.499268e-01 | 0.260 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 5.504421e-01 | 0.259 |
| R-HSA-111933 | Calmodulin induced events | 5.504421e-01 | 0.259 |
| R-HSA-111997 | CaM pathway | 5.504421e-01 | 0.259 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.546220e-01 | 0.256 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.546220e-01 | 0.256 |
| R-HSA-112316 | Neuronal System | 5.569840e-01 | 0.254 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.587346e-01 | 0.253 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.587346e-01 | 0.253 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.589415e-01 | 0.253 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.600011e-01 | 0.252 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.653338e-01 | 0.248 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.653338e-01 | 0.248 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 5.668747e-01 | 0.247 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 5.668747e-01 | 0.247 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 5.668747e-01 | 0.247 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 5.668747e-01 | 0.247 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.748651e-01 | 0.240 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.748651e-01 | 0.240 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 5.748651e-01 | 0.240 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.748651e-01 | 0.240 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.755585e-01 | 0.240 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.810526e-01 | 0.236 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.827086e-01 | 0.235 |
| R-HSA-202433 | Generation of second messenger molecules | 5.827086e-01 | 0.235 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 5.827086e-01 | 0.235 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 5.827086e-01 | 0.235 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.827086e-01 | 0.235 |
| R-HSA-5260271 | Diseases of Immune System | 5.827086e-01 | 0.235 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.827086e-01 | 0.235 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 5.827086e-01 | 0.235 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 5.827086e-01 | 0.235 |
| R-HSA-8982491 | Glycogen metabolism | 5.827086e-01 | 0.235 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 5.827086e-01 | 0.235 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.861988e-01 | 0.232 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.861988e-01 | 0.232 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.904079e-01 | 0.229 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.904079e-01 | 0.229 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.904079e-01 | 0.229 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 5.904079e-01 | 0.229 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.904079e-01 | 0.229 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.962114e-01 | 0.225 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 5.979656e-01 | 0.223 |
| R-HSA-167161 | HIV Transcription Initiation | 5.979656e-01 | 0.223 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 5.979656e-01 | 0.223 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.979656e-01 | 0.223 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.979656e-01 | 0.223 |
| R-HSA-72172 | mRNA Splicing | 5.985244e-01 | 0.223 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.013567e-01 | 0.221 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.013567e-01 | 0.221 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.013567e-01 | 0.221 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.013567e-01 | 0.221 |
| R-HSA-111996 | Ca-dependent events | 6.053842e-01 | 0.218 |
| R-HSA-165159 | MTOR signalling | 6.053842e-01 | 0.218 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 6.053842e-01 | 0.218 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.063157e-01 | 0.217 |
| R-HSA-416476 | G alpha (q) signalling events | 6.079593e-01 | 0.216 |
| R-HSA-70171 | Glycolysis | 6.112279e-01 | 0.214 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.112279e-01 | 0.214 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.122574e-01 | 0.213 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.122574e-01 | 0.213 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 6.126665e-01 | 0.213 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.160934e-01 | 0.210 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 6.198148e-01 | 0.208 |
| R-HSA-9907900 | Proteasome assembly | 6.198148e-01 | 0.208 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.209122e-01 | 0.207 |
| R-HSA-192823 | Viral mRNA Translation | 6.256843e-01 | 0.204 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 6.268316e-01 | 0.203 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.268316e-01 | 0.203 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 6.268316e-01 | 0.203 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 6.268316e-01 | 0.203 |
| R-HSA-9824272 | Somitogenesis | 6.268316e-01 | 0.203 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.304099e-01 | 0.200 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.337193e-01 | 0.198 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.337193e-01 | 0.198 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.337193e-01 | 0.198 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.337193e-01 | 0.198 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 6.337193e-01 | 0.198 |
| R-HSA-9839373 | Signaling by TGFBR3 | 6.337193e-01 | 0.198 |
| R-HSA-9675135 | Diseases of DNA repair | 6.337193e-01 | 0.198 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 6.404803e-01 | 0.193 |
| R-HSA-1483191 | Synthesis of PC | 6.404803e-01 | 0.193 |
| R-HSA-70263 | Gluconeogenesis | 6.471169e-01 | 0.189 |
| R-HSA-425410 | Metal ion SLC transporters | 6.471169e-01 | 0.189 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.488487e-01 | 0.188 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.533431e-01 | 0.185 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 6.536314e-01 | 0.185 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 6.536314e-01 | 0.185 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.536314e-01 | 0.185 |
| R-HSA-8951664 | Neddylation | 6.553408e-01 | 0.184 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.577918e-01 | 0.182 |
| R-HSA-392499 | Metabolism of proteins | 6.582312e-01 | 0.182 |
| R-HSA-912446 | Meiotic recombination | 6.663030e-01 | 0.176 |
| R-HSA-9864848 | Complex IV assembly | 6.663030e-01 | 0.176 |
| R-HSA-2514856 | The phototransduction cascade | 6.663030e-01 | 0.176 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.708642e-01 | 0.173 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.708642e-01 | 0.173 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.708642e-01 | 0.173 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.724645e-01 | 0.172 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.724645e-01 | 0.172 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.751312e-01 | 0.171 |
| R-HSA-1221632 | Meiotic synapsis | 6.785126e-01 | 0.168 |
| R-HSA-8956320 | Nucleotide biosynthesis | 6.785126e-01 | 0.168 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.835306e-01 | 0.165 |
| R-HSA-418555 | G alpha (s) signalling events | 6.859417e-01 | 0.164 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.876633e-01 | 0.163 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.876633e-01 | 0.163 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.902768e-01 | 0.161 |
| R-HSA-418597 | G alpha (z) signalling events | 6.902768e-01 | 0.161 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.917518e-01 | 0.160 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.927043e-01 | 0.159 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.927043e-01 | 0.159 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.950033e-01 | 0.158 |
| R-HSA-193648 | NRAGE signals death through JNK | 6.959970e-01 | 0.157 |
| R-HSA-5578775 | Ion homeostasis | 6.959970e-01 | 0.157 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.959970e-01 | 0.157 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.959970e-01 | 0.157 |
| R-HSA-70326 | Glucose metabolism | 6.997967e-01 | 0.155 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 7.016119e-01 | 0.154 |
| R-HSA-5621480 | Dectin-2 family | 7.016119e-01 | 0.154 |
| R-HSA-1483166 | Synthesis of PA | 7.016119e-01 | 0.154 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 7.016119e-01 | 0.154 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.076672e-01 | 0.150 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.076672e-01 | 0.150 |
| R-HSA-68875 | Mitotic Prophase | 7.115377e-01 | 0.148 |
| R-HSA-157118 | Signaling by NOTCH | 7.121785e-01 | 0.147 |
| R-HSA-180786 | Extension of Telomeres | 7.125336e-01 | 0.147 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 7.125336e-01 | 0.147 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.153652e-01 | 0.145 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.178440e-01 | 0.144 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 7.178440e-01 | 0.144 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 7.178440e-01 | 0.144 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 7.178440e-01 | 0.144 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 7.178440e-01 | 0.144 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 7.178440e-01 | 0.144 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.178440e-01 | 0.144 |
| R-HSA-351202 | Metabolism of polyamines | 7.178440e-01 | 0.144 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.191502e-01 | 0.143 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.191502e-01 | 0.143 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 7.230567e-01 | 0.141 |
| R-HSA-112043 | PLC beta mediated events | 7.230567e-01 | 0.141 |
| R-HSA-445717 | Aquaporin-mediated transport | 7.230567e-01 | 0.141 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 7.230567e-01 | 0.141 |
| R-HSA-8953854 | Metabolism of RNA | 7.233714e-01 | 0.141 |
| R-HSA-6784531 | tRNA processing in the nucleus | 7.281734e-01 | 0.138 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.281734e-01 | 0.138 |
| R-HSA-1268020 | Mitochondrial protein import | 7.281734e-01 | 0.138 |
| R-HSA-9707616 | Heme signaling | 7.281734e-01 | 0.138 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 7.331959e-01 | 0.135 |
| R-HSA-8848021 | Signaling by PTK6 | 7.331959e-01 | 0.135 |
| R-HSA-4839726 | Chromatin organization | 7.366033e-01 | 0.133 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.374456e-01 | 0.132 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 7.381259e-01 | 0.132 |
| R-HSA-936837 | Ion transport by P-type ATPases | 7.381259e-01 | 0.132 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.486810e-01 | 0.126 |
| R-HSA-112040 | G-protein mediated events | 7.523777e-01 | 0.124 |
| R-HSA-196807 | Nicotinate metabolism | 7.523777e-01 | 0.124 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.545003e-01 | 0.122 |
| R-HSA-1474165 | Reproduction | 7.547176e-01 | 0.122 |
| R-HSA-5576891 | Cardiac conduction | 7.580525e-01 | 0.120 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.658564e-01 | 0.116 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 7.658564e-01 | 0.116 |
| R-HSA-8978934 | Metabolism of cofactors | 7.701847e-01 | 0.113 |
| R-HSA-3000178 | ECM proteoglycans | 7.701847e-01 | 0.113 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.701847e-01 | 0.113 |
| R-HSA-189445 | Metabolism of porphyrins | 7.701847e-01 | 0.113 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.744334e-01 | 0.111 |
| R-HSA-74259 | Purine catabolism | 7.744334e-01 | 0.111 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.761793e-01 | 0.110 |
| R-HSA-4086398 | Ca2+ pathway | 7.786037e-01 | 0.109 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.812712e-01 | 0.107 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.812712e-01 | 0.107 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.829880e-01 | 0.106 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 7.867152e-01 | 0.104 |
| R-HSA-917937 | Iron uptake and transport | 7.867152e-01 | 0.104 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.906592e-01 | 0.102 |
| R-HSA-9694635 | Translation of Structural Proteins | 7.945305e-01 | 0.100 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.983304e-01 | 0.098 |
| R-HSA-216083 | Integrin cell surface interactions | 7.983304e-01 | 0.098 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 8.128425e-01 | 0.090 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 8.163048e-01 | 0.088 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.220671e-01 | 0.085 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 8.230392e-01 | 0.085 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.245811e-01 | 0.084 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 8.263135e-01 | 0.083 |
| R-HSA-1989781 | PPARA activates gene expression | 8.319328e-01 | 0.080 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.357786e-01 | 0.078 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.366789e-01 | 0.077 |
| R-HSA-9711097 | Cellular response to starvation | 8.390063e-01 | 0.076 |
| R-HSA-877300 | Interferon gamma signaling | 8.413038e-01 | 0.075 |
| R-HSA-73884 | Base Excision Repair | 8.418012e-01 | 0.075 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 8.418012e-01 | 0.075 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 8.504249e-01 | 0.070 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.523522e-01 | 0.069 |
| R-HSA-2029481 | FCGR activation | 8.531940e-01 | 0.069 |
| R-HSA-1474290 | Collagen formation | 8.559121e-01 | 0.068 |
| R-HSA-157579 | Telomere Maintenance | 8.662918e-01 | 0.062 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.666464e-01 | 0.062 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.704915e-01 | 0.060 |
| R-HSA-3214847 | HATs acetylate histones | 8.711987e-01 | 0.060 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.711987e-01 | 0.060 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.738618e-01 | 0.059 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.782246e-01 | 0.056 |
| R-HSA-111885 | Opioid Signalling | 8.826950e-01 | 0.054 |
| R-HSA-9833110 | RSV-host interactions | 8.848684e-01 | 0.053 |
| R-HSA-2559583 | Cellular Senescence | 8.848758e-01 | 0.053 |
| R-HSA-418346 | Platelet homeostasis | 8.890957e-01 | 0.051 |
| R-HSA-382551 | Transport of small molecules | 8.932885e-01 | 0.049 |
| R-HSA-372790 | Signaling by GPCR | 8.939284e-01 | 0.049 |
| R-HSA-5419276 | Mitochondrial translation termination | 8.951482e-01 | 0.048 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.977725e-01 | 0.047 |
| R-HSA-909733 | Interferon alpha/beta signaling | 9.097267e-01 | 0.041 |
| R-HSA-2980736 | Peptide hormone metabolism | 9.130439e-01 | 0.040 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.146211e-01 | 0.039 |
| R-HSA-428157 | Sphingolipid metabolism | 9.159012e-01 | 0.038 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 9.222840e-01 | 0.035 |
| R-HSA-6809371 | Formation of the cornified envelope | 9.237259e-01 | 0.034 |
| R-HSA-388396 | GPCR downstream signalling | 9.271388e-01 | 0.033 |
| R-HSA-8956319 | Nucleotide catabolism | 9.318343e-01 | 0.031 |
| R-HSA-9843745 | Adipogenesis | 9.355603e-01 | 0.029 |
| R-HSA-5368287 | Mitochondrial translation | 9.445335e-01 | 0.025 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.468839e-01 | 0.024 |
| R-HSA-72312 | rRNA processing | 9.485073e-01 | 0.023 |
| R-HSA-15869 | Metabolism of nucleotides | 9.516138e-01 | 0.022 |
| R-HSA-2187338 | Visual phototransduction | 9.540186e-01 | 0.020 |
| R-HSA-8957322 | Metabolism of steroids | 9.548505e-01 | 0.020 |
| R-HSA-9758941 | Gastrulation | 9.557120e-01 | 0.020 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.565352e-01 | 0.019 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 9.596785e-01 | 0.018 |
| R-HSA-9610379 | HCMV Late Events | 9.618862e-01 | 0.017 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.683558e-01 | 0.014 |
| R-HSA-5619102 | SLC transporter disorders | 9.684114e-01 | 0.014 |
| R-HSA-72306 | tRNA processing | 9.706981e-01 | 0.013 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.743767e-01 | 0.011 |
| R-HSA-3781865 | Diseases of glycosylation | 9.774779e-01 | 0.010 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.776429e-01 | 0.010 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.809855e-01 | 0.008 |
| R-HSA-6805567 | Keratinization | 9.853905e-01 | 0.006 |
| R-HSA-9748784 | Drug ADME | 9.883466e-01 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 9.900165e-01 | 0.004 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.905292e-01 | 0.004 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.962466e-01 | 0.002 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.963740e-01 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.965529e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.992087e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.995062e-01 | 0.000 |
| R-HSA-418594 | G alpha (i) signalling events | 9.996824e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.998680e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.999655e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.901 | 0.215 | 2 | 0.884 |
CLK3 |
0.893 | 0.266 | 1 | 0.871 |
MOS |
0.885 | 0.094 | 1 | 0.859 |
PIM3 |
0.883 | 0.088 | -3 | 0.820 |
PRPK |
0.883 | -0.077 | -1 | 0.857 |
IKKB |
0.883 | 0.006 | -2 | 0.794 |
CDC7 |
0.882 | 0.004 | 1 | 0.815 |
DSTYK |
0.881 | 0.078 | 2 | 0.899 |
RAF1 |
0.881 | 0.013 | 1 | 0.858 |
CAMK1B |
0.881 | 0.057 | -3 | 0.847 |
ERK5 |
0.880 | 0.168 | 1 | 0.891 |
CAMK2G |
0.880 | 0.027 | 2 | 0.829 |
MTOR |
0.879 | -0.057 | 1 | 0.843 |
FAM20C |
0.879 | 0.246 | 2 | 0.697 |
NDR2 |
0.879 | 0.042 | -3 | 0.824 |
NLK |
0.878 | 0.063 | 1 | 0.873 |
TBK1 |
0.877 | -0.025 | 1 | 0.774 |
GCN2 |
0.877 | -0.121 | 2 | 0.822 |
BMPR2 |
0.876 | -0.052 | -2 | 0.920 |
RSK2 |
0.876 | 0.099 | -3 | 0.750 |
ATR |
0.876 | -0.009 | 1 | 0.828 |
CDKL1 |
0.875 | 0.041 | -3 | 0.781 |
PDHK4 |
0.875 | -0.219 | 1 | 0.877 |
KIS |
0.875 | 0.131 | 1 | 0.754 |
IKKE |
0.874 | -0.029 | 1 | 0.768 |
GRK1 |
0.874 | 0.115 | -2 | 0.781 |
SKMLCK |
0.874 | 0.072 | -2 | 0.878 |
PIM1 |
0.874 | 0.117 | -3 | 0.775 |
SRPK1 |
0.874 | 0.114 | -3 | 0.729 |
GRK6 |
0.873 | 0.072 | 1 | 0.831 |
HIPK4 |
0.872 | 0.092 | 1 | 0.831 |
ULK2 |
0.872 | -0.142 | 2 | 0.809 |
IKKA |
0.871 | 0.050 | -2 | 0.777 |
PDHK1 |
0.871 | -0.140 | 1 | 0.868 |
NIK |
0.871 | -0.015 | -3 | 0.868 |
CAMLCK |
0.871 | 0.039 | -2 | 0.890 |
PRKD1 |
0.871 | 0.059 | -3 | 0.784 |
CDKL5 |
0.871 | 0.083 | -3 | 0.768 |
NDR1 |
0.871 | 0.016 | -3 | 0.820 |
PKN3 |
0.870 | 0.004 | -3 | 0.800 |
HUNK |
0.870 | -0.060 | 2 | 0.813 |
NUAK2 |
0.870 | 0.019 | -3 | 0.824 |
NEK6 |
0.869 | -0.023 | -2 | 0.900 |
PRKD2 |
0.869 | 0.084 | -3 | 0.744 |
P90RSK |
0.869 | 0.039 | -3 | 0.749 |
CHAK2 |
0.869 | -0.008 | -1 | 0.841 |
MARK4 |
0.869 | 0.024 | 4 | 0.871 |
MST4 |
0.869 | 0.026 | 2 | 0.860 |
NEK7 |
0.869 | -0.087 | -3 | 0.835 |
AMPKA1 |
0.869 | 0.052 | -3 | 0.834 |
RIPK3 |
0.868 | -0.078 | 3 | 0.784 |
LATS1 |
0.868 | 0.171 | -3 | 0.836 |
LATS2 |
0.868 | 0.034 | -5 | 0.801 |
MLK1 |
0.868 | -0.077 | 2 | 0.839 |
BMPR1B |
0.868 | 0.192 | 1 | 0.768 |
TGFBR2 |
0.868 | 0.011 | -2 | 0.861 |
WNK1 |
0.868 | -0.029 | -2 | 0.884 |
GRK5 |
0.867 | -0.128 | -3 | 0.853 |
ICK |
0.867 | 0.052 | -3 | 0.812 |
RSK3 |
0.867 | 0.039 | -3 | 0.741 |
DAPK2 |
0.867 | -0.010 | -3 | 0.846 |
P70S6KB |
0.866 | 0.041 | -3 | 0.780 |
PKCD |
0.866 | 0.053 | 2 | 0.819 |
CAMK2B |
0.866 | 0.107 | 2 | 0.810 |
PLK1 |
0.866 | 0.075 | -2 | 0.872 |
TGFBR1 |
0.865 | 0.157 | -2 | 0.866 |
CAMK2D |
0.865 | -0.006 | -3 | 0.813 |
PKACG |
0.865 | 0.052 | -2 | 0.786 |
MAPKAPK2 |
0.865 | 0.069 | -3 | 0.715 |
PKN2 |
0.865 | -0.003 | -3 | 0.822 |
TSSK2 |
0.865 | 0.050 | -5 | 0.831 |
ALK4 |
0.865 | 0.108 | -2 | 0.889 |
ATM |
0.864 | 0.021 | 1 | 0.754 |
MAPKAPK3 |
0.864 | 0.003 | -3 | 0.752 |
SRPK2 |
0.864 | 0.089 | -3 | 0.654 |
DLK |
0.864 | -0.104 | 1 | 0.838 |
BCKDK |
0.863 | -0.113 | -1 | 0.792 |
AMPKA2 |
0.863 | 0.051 | -3 | 0.803 |
TSSK1 |
0.863 | 0.066 | -3 | 0.848 |
AURC |
0.862 | 0.107 | -2 | 0.704 |
CAMK2A |
0.862 | 0.083 | 2 | 0.814 |
CDK8 |
0.862 | 0.060 | 1 | 0.708 |
ULK1 |
0.862 | -0.182 | -3 | 0.804 |
CLK4 |
0.861 | 0.116 | -3 | 0.752 |
GRK7 |
0.861 | 0.104 | 1 | 0.789 |
RSK4 |
0.861 | 0.093 | -3 | 0.723 |
CLK2 |
0.861 | 0.194 | -3 | 0.738 |
ANKRD3 |
0.861 | -0.090 | 1 | 0.864 |
GRK4 |
0.861 | -0.086 | -2 | 0.831 |
DYRK2 |
0.860 | 0.096 | 1 | 0.758 |
ALK2 |
0.860 | 0.150 | -2 | 0.869 |
PAK1 |
0.860 | 0.029 | -2 | 0.817 |
PLK3 |
0.860 | 0.057 | 2 | 0.781 |
NEK9 |
0.860 | -0.140 | 2 | 0.845 |
SRPK3 |
0.860 | 0.059 | -3 | 0.706 |
WNK3 |
0.859 | -0.224 | 1 | 0.836 |
ACVR2B |
0.859 | 0.115 | -2 | 0.864 |
PKACB |
0.859 | 0.112 | -2 | 0.728 |
PKR |
0.858 | 0.022 | 1 | 0.860 |
JNK2 |
0.858 | 0.134 | 1 | 0.680 |
MSK2 |
0.857 | -0.003 | -3 | 0.720 |
ACVR2A |
0.857 | 0.090 | -2 | 0.855 |
MASTL |
0.857 | -0.321 | -2 | 0.836 |
MLK2 |
0.857 | -0.129 | 2 | 0.848 |
CAMK4 |
0.857 | -0.066 | -3 | 0.806 |
JNK3 |
0.857 | 0.113 | 1 | 0.714 |
CLK1 |
0.856 | 0.116 | -3 | 0.727 |
RIPK1 |
0.856 | -0.196 | 1 | 0.834 |
MEK1 |
0.856 | -0.098 | 2 | 0.866 |
MSK1 |
0.856 | 0.061 | -3 | 0.727 |
CDK1 |
0.856 | 0.107 | 1 | 0.687 |
PAK3 |
0.856 | -0.021 | -2 | 0.822 |
MLK3 |
0.856 | -0.052 | 2 | 0.777 |
PRKX |
0.855 | 0.143 | -3 | 0.668 |
MYLK4 |
0.855 | 0.034 | -2 | 0.814 |
NIM1 |
0.855 | -0.099 | 3 | 0.826 |
CDK19 |
0.855 | 0.057 | 1 | 0.672 |
AURB |
0.854 | 0.076 | -2 | 0.703 |
BMPR1A |
0.854 | 0.177 | 1 | 0.737 |
YSK4 |
0.854 | -0.058 | 1 | 0.803 |
TTBK2 |
0.854 | -0.207 | 2 | 0.715 |
PRKD3 |
0.854 | 0.015 | -3 | 0.716 |
MLK4 |
0.854 | -0.036 | 2 | 0.770 |
NUAK1 |
0.853 | -0.028 | -3 | 0.778 |
P38B |
0.853 | 0.118 | 1 | 0.720 |
MELK |
0.853 | -0.029 | -3 | 0.783 |
P38A |
0.853 | 0.089 | 1 | 0.780 |
QSK |
0.853 | 0.016 | 4 | 0.838 |
VRK2 |
0.852 | -0.205 | 1 | 0.887 |
IRE1 |
0.852 | -0.125 | 1 | 0.820 |
CDK7 |
0.852 | 0.032 | 1 | 0.722 |
BRSK1 |
0.852 | 0.005 | -3 | 0.770 |
PKCB |
0.851 | -0.003 | 2 | 0.763 |
DNAPK |
0.851 | 0.031 | 1 | 0.723 |
MNK2 |
0.851 | -0.001 | -2 | 0.831 |
TLK2 |
0.851 | -0.030 | 1 | 0.787 |
HIPK1 |
0.851 | 0.108 | 1 | 0.776 |
PKCG |
0.851 | -0.029 | 2 | 0.765 |
SIK |
0.850 | -0.003 | -3 | 0.741 |
PIM2 |
0.850 | 0.063 | -3 | 0.725 |
HIPK2 |
0.850 | 0.115 | 1 | 0.672 |
CDK5 |
0.850 | 0.077 | 1 | 0.738 |
CDK18 |
0.850 | 0.088 | 1 | 0.666 |
PKCA |
0.850 | -0.005 | 2 | 0.759 |
PAK2 |
0.850 | -0.035 | -2 | 0.804 |
QIK |
0.850 | -0.094 | -3 | 0.808 |
IRE2 |
0.850 | -0.072 | 2 | 0.775 |
MARK2 |
0.849 | 0.018 | 4 | 0.783 |
ERK1 |
0.849 | 0.081 | 1 | 0.705 |
PKG2 |
0.849 | 0.053 | -2 | 0.727 |
MARK3 |
0.849 | 0.026 | 4 | 0.807 |
CHK1 |
0.849 | -0.008 | -3 | 0.813 |
CDK13 |
0.849 | 0.033 | 1 | 0.704 |
SMG1 |
0.849 | -0.070 | 1 | 0.780 |
AURA |
0.848 | 0.053 | -2 | 0.671 |
P38G |
0.848 | 0.093 | 1 | 0.609 |
SGK3 |
0.848 | 0.040 | -3 | 0.739 |
ERK2 |
0.848 | 0.050 | 1 | 0.750 |
MNK1 |
0.848 | 0.001 | -2 | 0.837 |
BRAF |
0.847 | -0.021 | -4 | 0.840 |
AKT2 |
0.847 | 0.043 | -3 | 0.669 |
GRK2 |
0.847 | -0.047 | -2 | 0.734 |
PKCH |
0.847 | -0.042 | 2 | 0.749 |
NEK2 |
0.847 | -0.108 | 2 | 0.824 |
DYRK4 |
0.846 | 0.107 | 1 | 0.683 |
PAK6 |
0.846 | 0.029 | -2 | 0.758 |
PASK |
0.846 | 0.041 | -3 | 0.832 |
CAMK1G |
0.846 | -0.022 | -3 | 0.742 |
CHAK1 |
0.846 | -0.152 | 2 | 0.798 |
PHKG1 |
0.846 | -0.089 | -3 | 0.808 |
DCAMKL1 |
0.845 | -0.007 | -3 | 0.766 |
PKCZ |
0.845 | -0.066 | 2 | 0.801 |
BRSK2 |
0.845 | -0.067 | -3 | 0.793 |
DYRK1A |
0.845 | 0.050 | 1 | 0.793 |
CDK2 |
0.845 | 0.026 | 1 | 0.764 |
CDK17 |
0.844 | 0.067 | 1 | 0.613 |
MEKK3 |
0.844 | -0.132 | 1 | 0.826 |
GSK3A |
0.843 | 0.109 | 4 | 0.530 |
PKACA |
0.843 | 0.082 | -2 | 0.679 |
TLK1 |
0.843 | -0.042 | -2 | 0.871 |
MARK1 |
0.843 | -0.015 | 4 | 0.825 |
PERK |
0.843 | -0.115 | -2 | 0.879 |
MAPKAPK5 |
0.843 | -0.120 | -3 | 0.691 |
PINK1 |
0.842 | -0.125 | 1 | 0.843 |
CDK3 |
0.842 | 0.106 | 1 | 0.629 |
CDK12 |
0.842 | 0.033 | 1 | 0.681 |
HIPK3 |
0.842 | 0.056 | 1 | 0.782 |
HRI |
0.841 | -0.158 | -2 | 0.898 |
PLK2 |
0.841 | 0.111 | -3 | 0.834 |
SSTK |
0.841 | 0.041 | 4 | 0.822 |
MEKK2 |
0.841 | -0.097 | 2 | 0.827 |
GSK3B |
0.841 | 0.059 | 4 | 0.519 |
PLK4 |
0.841 | -0.120 | 2 | 0.651 |
DRAK1 |
0.841 | -0.123 | 1 | 0.755 |
SMMLCK |
0.841 | -0.013 | -3 | 0.797 |
MEK5 |
0.841 | -0.256 | 2 | 0.846 |
P38D |
0.841 | 0.115 | 1 | 0.618 |
NEK5 |
0.841 | -0.090 | 1 | 0.847 |
CDK9 |
0.841 | 0.007 | 1 | 0.716 |
PRP4 |
0.840 | -0.005 | -3 | 0.729 |
MEKK1 |
0.840 | -0.171 | 1 | 0.819 |
SNRK |
0.840 | -0.204 | 2 | 0.701 |
DYRK1B |
0.840 | 0.069 | 1 | 0.711 |
P70S6K |
0.839 | -0.006 | -3 | 0.684 |
DYRK3 |
0.839 | 0.073 | 1 | 0.775 |
DCAMKL2 |
0.839 | -0.039 | -3 | 0.792 |
GAK |
0.839 | 0.042 | 1 | 0.852 |
CAMK1D |
0.839 | 0.024 | -3 | 0.670 |
MST3 |
0.839 | -0.044 | 2 | 0.844 |
TAO3 |
0.839 | -0.049 | 1 | 0.826 |
CK1E |
0.838 | -0.031 | -3 | 0.591 |
ZAK |
0.838 | -0.175 | 1 | 0.794 |
CDK14 |
0.837 | 0.056 | 1 | 0.708 |
AKT1 |
0.837 | 0.042 | -3 | 0.687 |
CK2A2 |
0.836 | 0.091 | 1 | 0.671 |
WNK4 |
0.836 | -0.157 | -2 | 0.871 |
CDK16 |
0.835 | 0.081 | 1 | 0.631 |
JNK1 |
0.835 | 0.083 | 1 | 0.665 |
CDK10 |
0.835 | 0.088 | 1 | 0.691 |
CK1D |
0.835 | -0.005 | -3 | 0.540 |
DAPK3 |
0.835 | 0.036 | -3 | 0.784 |
ERK7 |
0.834 | 0.055 | 2 | 0.584 |
IRAK4 |
0.834 | -0.143 | 1 | 0.828 |
GRK3 |
0.834 | -0.039 | -2 | 0.683 |
CK1G1 |
0.833 | -0.037 | -3 | 0.590 |
CK1A2 |
0.833 | -0.006 | -3 | 0.540 |
NEK8 |
0.833 | -0.150 | 2 | 0.830 |
PKCT |
0.832 | -0.057 | 2 | 0.758 |
MST2 |
0.832 | -0.000 | 1 | 0.828 |
CAMKK1 |
0.832 | -0.144 | -2 | 0.805 |
PHKG2 |
0.832 | -0.079 | -3 | 0.779 |
MPSK1 |
0.830 | -0.060 | 1 | 0.800 |
LKB1 |
0.830 | -0.092 | -3 | 0.811 |
GCK |
0.830 | -0.014 | 1 | 0.825 |
PDHK3_TYR |
0.829 | 0.231 | 4 | 0.915 |
CAMKK2 |
0.829 | -0.126 | -2 | 0.799 |
TAO2 |
0.829 | -0.128 | 2 | 0.860 |
EEF2K |
0.829 | -0.021 | 3 | 0.857 |
PKCI |
0.828 | -0.051 | 2 | 0.772 |
TNIK |
0.828 | 0.009 | 3 | 0.877 |
DAPK1 |
0.828 | 0.015 | -3 | 0.766 |
PDK1 |
0.828 | -0.125 | 1 | 0.825 |
SGK1 |
0.828 | 0.055 | -3 | 0.592 |
MAK |
0.827 | 0.111 | -2 | 0.743 |
PKCE |
0.827 | -0.005 | 2 | 0.749 |
NEK11 |
0.827 | -0.241 | 1 | 0.815 |
TTBK1 |
0.826 | -0.221 | 2 | 0.633 |
NEK4 |
0.826 | -0.117 | 1 | 0.826 |
PAK5 |
0.826 | -0.027 | -2 | 0.683 |
CK2A1 |
0.825 | 0.063 | 1 | 0.652 |
HGK |
0.825 | -0.053 | 3 | 0.875 |
ROCK2 |
0.825 | 0.067 | -3 | 0.770 |
MINK |
0.825 | -0.048 | 1 | 0.827 |
CAMK1A |
0.825 | 0.016 | -3 | 0.635 |
TAK1 |
0.825 | -0.088 | 1 | 0.820 |
MRCKA |
0.824 | 0.042 | -3 | 0.741 |
MRCKB |
0.824 | 0.046 | -3 | 0.720 |
AKT3 |
0.824 | 0.041 | -3 | 0.604 |
LRRK2 |
0.823 | -0.160 | 2 | 0.853 |
PAK4 |
0.823 | -0.016 | -2 | 0.688 |
CHK2 |
0.823 | -0.018 | -3 | 0.614 |
IRAK1 |
0.823 | -0.310 | -1 | 0.735 |
HPK1 |
0.823 | -0.033 | 1 | 0.823 |
MST1 |
0.823 | -0.056 | 1 | 0.824 |
MOK |
0.823 | 0.088 | 1 | 0.806 |
NEK1 |
0.823 | -0.097 | 1 | 0.833 |
BUB1 |
0.822 | 0.084 | -5 | 0.801 |
PDHK4_TYR |
0.821 | 0.096 | 2 | 0.894 |
CDK6 |
0.821 | 0.043 | 1 | 0.687 |
MAP3K15 |
0.821 | -0.183 | 1 | 0.790 |
LOK |
0.821 | -0.070 | -2 | 0.807 |
BMPR2_TYR |
0.821 | 0.107 | -1 | 0.899 |
VRK1 |
0.821 | -0.195 | 2 | 0.841 |
MAP2K6_TYR |
0.821 | 0.075 | -1 | 0.880 |
MEKK6 |
0.820 | -0.185 | 1 | 0.821 |
MAP2K4_TYR |
0.820 | 0.020 | -1 | 0.879 |
KHS1 |
0.820 | 0.010 | 1 | 0.824 |
SBK |
0.820 | 0.029 | -3 | 0.551 |
CDK4 |
0.820 | 0.040 | 1 | 0.668 |
SLK |
0.819 | -0.082 | -2 | 0.742 |
KHS2 |
0.818 | 0.032 | 1 | 0.831 |
DMPK1 |
0.818 | 0.082 | -3 | 0.746 |
PKN1 |
0.818 | -0.056 | -3 | 0.699 |
TESK1_TYR |
0.818 | -0.061 | 3 | 0.909 |
PDHK1_TYR |
0.817 | 0.021 | -1 | 0.898 |
TTK |
0.817 | 0.043 | -2 | 0.870 |
STK33 |
0.817 | -0.177 | 2 | 0.640 |
MAP2K7_TYR |
0.816 | -0.173 | 2 | 0.871 |
EPHA6 |
0.815 | 0.119 | -1 | 0.904 |
MEK2 |
0.814 | -0.253 | 2 | 0.831 |
PKMYT1_TYR |
0.814 | -0.111 | 3 | 0.882 |
OSR1 |
0.814 | -0.029 | 2 | 0.829 |
PINK1_TYR |
0.814 | -0.131 | 1 | 0.861 |
PBK |
0.813 | -0.040 | 1 | 0.782 |
CRIK |
0.813 | 0.057 | -3 | 0.681 |
YSK1 |
0.812 | -0.138 | 2 | 0.818 |
LIMK2_TYR |
0.812 | -0.019 | -3 | 0.870 |
EPHB4 |
0.811 | 0.067 | -1 | 0.873 |
ROCK1 |
0.810 | 0.039 | -3 | 0.737 |
RET |
0.810 | -0.054 | 1 | 0.838 |
RIPK2 |
0.810 | -0.302 | 1 | 0.758 |
HASPIN |
0.809 | 0.011 | -1 | 0.707 |
ALPHAK3 |
0.809 | -0.017 | -1 | 0.797 |
PKG1 |
0.808 | -0.008 | -2 | 0.647 |
ABL2 |
0.807 | 0.050 | -1 | 0.821 |
TYK2 |
0.806 | -0.110 | 1 | 0.832 |
MST1R |
0.806 | -0.108 | 3 | 0.838 |
DDR1 |
0.806 | -0.081 | 4 | 0.836 |
YES1 |
0.806 | 0.011 | -1 | 0.853 |
INSRR |
0.805 | 0.017 | 3 | 0.783 |
CSF1R |
0.804 | -0.066 | 3 | 0.818 |
EPHA4 |
0.804 | 0.016 | 2 | 0.783 |
TXK |
0.804 | 0.071 | 1 | 0.811 |
LIMK1_TYR |
0.803 | -0.219 | 2 | 0.867 |
JAK2 |
0.803 | -0.108 | 1 | 0.830 |
BIKE |
0.803 | -0.002 | 1 | 0.733 |
NEK3 |
0.803 | -0.209 | 1 | 0.791 |
TYRO3 |
0.803 | -0.127 | 3 | 0.823 |
ROS1 |
0.803 | -0.103 | 3 | 0.794 |
YANK3 |
0.802 | -0.072 | 2 | 0.420 |
JAK3 |
0.802 | -0.041 | 1 | 0.809 |
FGR |
0.802 | -0.054 | 1 | 0.867 |
EPHB1 |
0.801 | 0.006 | 1 | 0.839 |
FGFR2 |
0.801 | -0.048 | 3 | 0.833 |
ABL1 |
0.801 | 0.011 | -1 | 0.811 |
FER |
0.800 | -0.095 | 1 | 0.859 |
MYO3B |
0.800 | -0.093 | 2 | 0.838 |
ASK1 |
0.800 | -0.211 | 1 | 0.777 |
EPHB2 |
0.800 | 0.032 | -1 | 0.857 |
TNK2 |
0.799 | -0.025 | 3 | 0.792 |
BLK |
0.799 | 0.085 | -1 | 0.860 |
EPHB3 |
0.799 | -0.006 | -1 | 0.854 |
MYO3A |
0.799 | -0.105 | 1 | 0.817 |
SRMS |
0.799 | -0.038 | 1 | 0.839 |
LCK |
0.799 | 0.044 | -1 | 0.854 |
HCK |
0.799 | -0.031 | -1 | 0.848 |
KIT |
0.798 | -0.082 | 3 | 0.825 |
KDR |
0.797 | -0.063 | 3 | 0.792 |
FLT3 |
0.797 | -0.095 | 3 | 0.823 |
PDGFRB |
0.796 | -0.138 | 3 | 0.835 |
FYN |
0.796 | 0.073 | -1 | 0.842 |
CK1A |
0.795 | -0.051 | -3 | 0.457 |
FGFR1 |
0.794 | -0.102 | 3 | 0.798 |
ITK |
0.794 | -0.071 | -1 | 0.807 |
NEK10_TYR |
0.794 | -0.081 | 1 | 0.725 |
TAO1 |
0.793 | -0.172 | 1 | 0.761 |
MET |
0.793 | -0.085 | 3 | 0.814 |
LTK |
0.792 | -0.059 | 3 | 0.775 |
FLT1 |
0.792 | -0.040 | -1 | 0.872 |
MERTK |
0.792 | -0.070 | 3 | 0.807 |
EPHA7 |
0.792 | -0.023 | 2 | 0.787 |
EPHA3 |
0.792 | -0.061 | 2 | 0.760 |
STLK3 |
0.792 | -0.183 | 1 | 0.768 |
BMX |
0.791 | -0.045 | -1 | 0.750 |
FGFR3 |
0.791 | -0.066 | 3 | 0.808 |
TEC |
0.791 | -0.053 | -1 | 0.753 |
JAK1 |
0.791 | -0.074 | 1 | 0.779 |
DDR2 |
0.791 | 0.030 | 3 | 0.772 |
AXL |
0.791 | -0.131 | 3 | 0.804 |
NTRK1 |
0.791 | -0.120 | -1 | 0.832 |
ALK |
0.790 | -0.107 | 3 | 0.752 |
TNK1 |
0.790 | -0.126 | 3 | 0.806 |
TEK |
0.790 | -0.170 | 3 | 0.768 |
TNNI3K_TYR |
0.789 | -0.078 | 1 | 0.840 |
EPHA5 |
0.788 | 0.010 | 2 | 0.774 |
PTK2 |
0.788 | 0.093 | -1 | 0.865 |
ERBB2 |
0.788 | -0.135 | 1 | 0.786 |
PDGFRA |
0.787 | -0.229 | 3 | 0.831 |
BTK |
0.786 | -0.182 | -1 | 0.762 |
FLT4 |
0.786 | -0.130 | 3 | 0.788 |
INSR |
0.786 | -0.104 | 3 | 0.755 |
FRK |
0.786 | -0.073 | -1 | 0.856 |
AAK1 |
0.786 | 0.041 | 1 | 0.637 |
NTRK2 |
0.785 | -0.153 | 3 | 0.792 |
EGFR |
0.785 | -0.023 | 1 | 0.695 |
LYN |
0.785 | -0.052 | 3 | 0.748 |
PTK2B |
0.784 | -0.054 | -1 | 0.784 |
EPHA8 |
0.784 | -0.034 | -1 | 0.844 |
SRC |
0.784 | -0.031 | -1 | 0.831 |
NTRK3 |
0.783 | -0.113 | -1 | 0.785 |
EPHA1 |
0.783 | -0.120 | 3 | 0.791 |
PTK6 |
0.783 | -0.222 | -1 | 0.725 |
FGFR4 |
0.782 | -0.046 | -1 | 0.799 |
WEE1_TYR |
0.782 | -0.168 | -1 | 0.745 |
CK1G3 |
0.781 | -0.021 | -3 | 0.411 |
SYK |
0.781 | 0.047 | -1 | 0.834 |
MATK |
0.779 | -0.135 | -1 | 0.747 |
CSK |
0.779 | -0.129 | 2 | 0.788 |
IGF1R |
0.776 | -0.075 | 3 | 0.701 |
EPHA2 |
0.776 | -0.025 | -1 | 0.827 |
ERBB4 |
0.772 | -0.027 | 1 | 0.697 |
YANK2 |
0.771 | -0.099 | 2 | 0.445 |
MUSK |
0.766 | -0.173 | 1 | 0.696 |
CK1G2 |
0.764 | -0.031 | -3 | 0.506 |
ZAP70 |
0.756 | -0.034 | -1 | 0.747 |
FES |
0.754 | -0.171 | -1 | 0.725 |