Motif 713 (n=184)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087WZ62 | None | S249 | ochoa | Mannosyltransferase (EC 2.4.1.-) | None |
| A0A0J9YX86 | GOLGA8Q | S230 | ochoa | Golgin A8 family member Q | None |
| A6NMY6 | ANXA2P2 | S89 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| A6NMY6 | ANXA2P2 | S134 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| I6L899 | GOLGA8R | S230 | ochoa | Golgin subfamily A member 8R | None |
| M0QZ92 | None | S40 | ochoa | SEC7 domain-containing protein | None |
| M0R2C6 | None | S196 | ochoa | serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (Seryl-tRNA(Ser/Sec) synthetase) | None |
| O14579 | COPE | S76 | ochoa | Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| O14965 | AURKA | S284 | psp | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| O15031 | PLXNB2 | S1244 | ochoa | Plexin-B2 (MM1) | Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus (PubMed:29100074, PubMed:32510170). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458). Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888). May modulate the activity of RAC1 and CDC42 (By similarity). {ECO:0000250|UniProtKB:B2RXS4, ECO:0000269|PubMed:12183458, ECO:0000269|PubMed:15184888, ECO:0000269|PubMed:29100074, ECO:0000269|PubMed:32510170}. |
| O15155 | BET1 | S69 | ochoa | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | Required for vesicular transport from the ER to the Golgi complex (PubMed:34779586). Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). {ECO:0000250|UniProtKB:Q62896, ECO:0000269|PubMed:34779586}. |
| O15400 | STX7 | S173 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O60437 | PPL | S915 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O60437 | PPL | S1331 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O60449 | LY75 | S1702 | ochoa | Lymphocyte antigen 75 (Ly-75) (C-type lectin domain family 13 member B) (DEC-205) (gp200-MR6) (CD antigen CD205) | Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. {ECO:0000250}. |
| O60664 | PLIN3 | S130 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60784 | TOM1 | S359 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O75781 | PALM | S62 | ochoa | Paralemmin-1 (Paralemmin) | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
| P04035 | HMGCR | S504 | ochoa | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799). {ECO:0000269|PubMed:11349148, ECO:0000269|PubMed:18540668, ECO:0000269|PubMed:21357570, ECO:0000269|PubMed:2991281, ECO:0000269|PubMed:36745799, ECO:0000269|PubMed:6995544}. |
| P04083 | ANXA1 | S143 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P04350 | TUBB4A | S234 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P05062 | ALDOB | S36 | ochoa | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). {ECO:0000269|PubMed:10970798, ECO:0000269|PubMed:12205126, ECO:0000269|PubMed:20848650, ECO:0000269|PubMed:35122041}. |
| P05090 | APOD | S169 | ochoa | Apolipoprotein D (Apo-D) (ApoD) | APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts. |
| P05783 | KRT18 | S312 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P07355 | ANXA2 | S89 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07355 | ANXA2 | S134 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07437 | TUBB | S234 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P08670 | VIM | S144 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P08670 | VIM | S205 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P08758 | ANXA5 | S116 | ochoa | Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
| P11055 | MYH3 | S1336 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | S1339 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S879 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T1307 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1335 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1596 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1337 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1598 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1338 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13929 | ENO3 | S83 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P15822 | HIVEP1 | S65 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P17568 | NDUFB7 | S73 | ochoa | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (Cell adhesion protein SQM1) (Complex I-B18) (CI-B18) (NADH-ubiquinone oxidoreductase B18 subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:33502047}. |
| P17661 | DES | S358 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P17844 | DDX5 | S480 | ochoa | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| P18206 | VCL | S290 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P20700 | LMNB1 | S200 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P27816 | MAP4 | S280 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28290 | ITPRID2 | S1010 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P31327 | CPS1 | S137 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P33991 | MCM4 | S145 | ochoa | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35523 | CLCN1 | S886 | ochoa | Chloride channel protein 1 (ClC-1) (Chloride channel protein, skeletal muscle) | Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing (PubMed:12456816, PubMed:16027167, PubMed:22521272, PubMed:22641783, PubMed:26007199, PubMed:26502825, PubMed:26510092, PubMed:7951242, PubMed:8112288, PubMed:8130334, PubMed:9122265, PubMed:9565403, PubMed:9736777). Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization (PubMed:10051520, PubMed:10962018, PubMed:29809153, PubMed:31022181). Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide (PubMed:9122265, PubMed:9565403). {ECO:0000269|PubMed:10051520, ECO:0000269|PubMed:10962018, ECO:0000269|PubMed:12456816, ECO:0000269|PubMed:16027167, ECO:0000269|PubMed:22521272, ECO:0000269|PubMed:22641783, ECO:0000269|PubMed:26007199, ECO:0000269|PubMed:26502825, ECO:0000269|PubMed:26510092, ECO:0000269|PubMed:29809153, ECO:0000269|PubMed:31022181, ECO:0000269|PubMed:7951242, ECO:0000269|PubMed:8112288, ECO:0000269|PubMed:8130334, ECO:0000269|PubMed:9122265, ECO:0000269|PubMed:9565403, ECO:0000269|PubMed:9736777}. |
| P35579 | MYH9 | S1916 | ochoa|psp | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | T1368 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P36897 | TGFBR1 | S360 | ochoa | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis (PubMed:33914044). The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}. |
| P36955 | SERPINF1 | S114 | psp | Pigment epithelium-derived factor (PEDF) (Cell proliferation-inducing gene 35 protein) (EPC-1) (Serpin F1) | Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}. |
| P40926 | MDH2 | S69 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P41229 | KDM5C | S897 | ochoa | Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:28262558}. |
| P42566 | EPS15 | S470 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P42684 | ABL2 | S121 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P42768 | WAS | S287 | ochoa | Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp) | Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:12235133, ECO:0000269|PubMed:12769847, ECO:0000269|PubMed:16275905, ECO:0000269|PubMed:18650809, ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:8625410, ECO:0000269|PubMed:9405671}. |
| P42892 | ECE1 | S51 | ochoa | Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) | Converts big endothelin-1 to endothelin-1. {ECO:0000269|PubMed:37835445, ECO:0000269|PubMed:9396733}. |
| P46939 | UTRN | S1258 | psp | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P46939 | UTRN | S2615 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P49321 | NASP | S662 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49902 | NT5C2 | S408 | ochoa | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P51956 | NEK3 | S462 | ochoa | Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3) | Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286, ECO:0000269|PubMed:17297458}. |
| P53675 | CLTCL1 | S1222 | ochoa | Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}. |
| P55072 | VCP | S416 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P61244 | MAX | S108 | ochoa | Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}. |
| P68371 | TUBB4B | S234 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78559 | MAP1A | S874 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q00610 | CLTC | S1222 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q05682 | CALD1 | S131 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q08379 | GOLGA2 | S774 | ochoa | Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) | Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940, ECO:0000305|PubMed:26363069}. |
| Q12893 | TMEM115 | S267 | ochoa | Transmembrane protein 115 (Placental protein 6) (Protein PL6) | May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. {ECO:0000269|PubMed:24806965}. |
| Q12905 | ILF2 | S218 | ochoa | Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa) | Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:18458058, PubMed:31212927). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay (PubMed:32433969). Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71. {ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:11739746, ECO:0000269|PubMed:18458058, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:31212927, ECO:0000269|PubMed:32433969, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12955 | ANK3 | S4229 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13118 | KLF10 | S184 | ochoa | Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}. |
| Q13263 | TRIM28 | S501 | ochoa|psp | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13416 | ORC2 | S282 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13555 | CAMK2G | S311 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13813 | SPTAN1 | S1291 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13885 | TUBB2A | S234 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14980 | NUMA1 | S1187 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15058 | KIF14 | S56 | ochoa|psp | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15149 | PLEC | S1721 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15149 | PLEC | S3143 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15149 | PLEC | S4054 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15672 | TWIST1 | S144 | psp | Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist) | Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:P26687, ECO:0000269|PubMed:12553906, ECO:0000269|PubMed:25981568}. |
| Q15785 | TOMM34 | S231 | ochoa | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
| Q2LD37 | BLTP1 | S3562 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q4LE39 | ARID4B | S1256 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q53EZ4 | CEP55 | S285 | ochoa | Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) | Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}. |
| Q5SW79 | CEP170 | S654 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T5P2 | KIAA1217 | S809 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TZA2 | CROCC | S1660 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5W0Q7 | USPL1 | S908 | ochoa | SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1) | SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}. |
| Q6MZZ7 | CAPN13 | S608 | ochoa | Calpain-13 (EC 3.4.22.-) (Calcium-activated neutral proteinase 13) (CANP 13) | Probable non-lysosomal thiol-protease. {ECO:0000250}. |
| Q6NUQ4 | TMEM214 | S456 | ochoa | Transmembrane protein 214 | Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress. {ECO:0000269|PubMed:23661706}. |
| Q6PJG6 | BRAT1 | S742 | ochoa | Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}. |
| Q6PL18 | ATAD2 | S671 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q70EL4 | USP43 | S1065 | ochoa | Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) | May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}. |
| Q7L7X3 | TAOK1 | S554 | psp | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q7Z406 | MYH14 | S1329 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q7Z417 | NUFIP2 | S607 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z7A1 | CNTRL | S2202 | ochoa | Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) | Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. {ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:16213214}. |
| Q86V48 | LUZP1 | S608 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q8IX12 | CCAR1 | S1078 | ochoa | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}. |
| Q8N3D4 | EHBP1L1 | S173 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N5G2 | MACO1 | S228 | ochoa | Macoilin (Macoilin-1) (Transmembrane protein 57) | Plays a role in the regulation of neuronal activity. {ECO:0000269|PubMed:21589894}. |
| Q8NB16 | MLKL | S358 | psp | Mixed lineage kinase domain-like protein (hMLKL) | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610). {ECO:0000250|UniProtKB:Q9D2Y4, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:29883610}. |
| Q8NCY6 | MSANTD4 | S286 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 4 (Myb/SANT-like DNA-binding domain containing 4 with coiled-coils) | None |
| Q8NDI1 | EHBP1 | S174 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NFW9 | MYRIP | S350 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Q8TDY2 | RB1CC1 | S982 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8WWY3 | PRPF31 | S307 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:20118938, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). {ECO:0000269|PubMed:11867543, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:28781166}. |
| Q8WXH0 | SYNE2 | S5860 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q8WYL5 | SSH1 | S812 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q8WZ42 | TTN | S4092 | psp | Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) | Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. {ECO:0000269|PubMed:11846417, ECO:0000269|PubMed:9804419}. |
| Q8WZ75 | ROBO4 | S657 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92508 | PIEZO1 | S544 | ochoa | Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:E2JF22, ECO:0000250|UniProtKB:Q91X60, ECO:0000269|PubMed:25955826, ECO:0000269|PubMed:29799007}. |
| Q92547 | TOPBP1 | S879 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92797 | SYMPK | S1081 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q96AE4 | FUBP1 | S55 | ochoa | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96CV9 | OPTN | S170 | ochoa | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
| Q96ED9 | HOOK2 | S316 | ochoa | Protein Hook homolog 2 (h-hook2) (hHK2) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q96HP0 | DOCK6 | S407 | ochoa | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q96PV7 | FAM193B | S393 | ochoa | Protein FAM193B | None |
| Q96T23 | RSF1 | S218 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96TC7 | RMDN3 | S233 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q99418 | CYTH2 | S56 | ochoa | Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) | Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}. |
| Q99717 | SMAD5 | S58 | ochoa | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}. |
| Q99956 | DUSP9 | S325 | ochoa | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | Inactivates MAP kinases. Has a specificity for the ERK family. |
| Q9BRQ6 | CHCHD6 | S75 | ochoa | MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}. |
| Q9BVA1 | TUBB2B | S234 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BWH6 | RPAP1 | S264 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BY66 | KDM5D | S884 | ochoa | Lysine-specific demethylase 5D (EC 1.14.11.67) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY) ([histone H3]-trimethyl-L-lysine(4) demethylase 5D) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. {ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:17351630, ECO:0000269|PubMed:26747897, ECO:0000269|PubMed:27185910, ECO:0000269|PubMed:27427228, ECO:0000269|PubMed:27477906}. |
| Q9BYG4 | PARD6G | S351 | ochoa | Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D) | Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). {ECO:0000250}. |
| Q9GZY8 | MFF | S234 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H0A0 | NAT10 | S957 | ochoa | RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) | RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}. |
| Q9H7Z7 | PTGES2 | S90 | ochoa | Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form] | Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:17585783, PubMed:18198127). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:17585783, PubMed:18198127). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity) (PubMed:17585783). {ECO:0000250|UniProtKB:Q9N0A4, ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:17585783, ECO:0000269|PubMed:18198127}. |
| Q9H845 | ACAD9 | S461 | ochoa | Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-) | As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852, PubMed:32320651). This moonlighting protein also has a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852). {ECO:0000269|PubMed:12359260, ECO:0000269|PubMed:16020546, ECO:0000269|PubMed:20816094, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:24158852, ECO:0000269|PubMed:32320651}. |
| Q9HCY8 | S100A14 | S77 | ochoa | Protein S100-A14 (S100 calcium-binding protein A14) (S114) | Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898, ECO:0000269|PubMed:22451655}. |
| Q9NP81 | SARS2 | S126 | ochoa | Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). {ECO:0000250|UniProtKB:Q9N0F3}. |
| Q9NPD8 | UBE2T | S172 | ochoa | Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (Cell proliferation-inducing gene 50 protein) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386). {ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:19887602, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:28437106}. |
| Q9NQP4 | PFDN4 | S107 | ochoa | Prefoldin subunit 4 (Protein C-1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q9NRA8 | EIF4ENIF1 | S374 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NZN5 | ARHGEF12 | S1273 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P219 | CCDC88C | S951 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P2E9 | RRBP1 | S959 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9UDT6 | CLIP2 | S923 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UGN5 | PARP2 | S353 | ochoa | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:25043379, PubMed:27471034, PubMed:30104678, PubMed:32028527, PubMed:32939087, PubMed:34108479, PubMed:34486521, PubMed:34874266). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379, PubMed:30104678, PubMed:30321391). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:32939087). Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (PubMed:25043379). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site (PubMed:28190768, PubMed:32028527, PubMed:34108479, PubMed:34486521, PubMed:34874266). PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:10364231, PubMed:32939087, PubMed:34108479). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP2 in order to limit the length of poly-ADP-ribose chains (PubMed:34732825, PubMed:34795260). Specifically mediates formation of branched poly-ADP-ribosylation (PubMed:30104678). Branched poly-ADP-ribose chains are specifically recognized by some factors, such as APLF (PubMed:30104678). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034, PubMed:29361132). {ECO:0000269|PubMed:10364231, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29361132, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30321391, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32939087, ECO:0000269|PubMed:34108479, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266}. |
| Q9UJV9 | DDX41 | S289 | ochoa | Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) | Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:34473945). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses (PubMed:23222971). Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1 (PubMed:25704810). Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity (PubMed:35613581). In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:35613581). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing (PubMed:33650667). Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability (PubMed:36229594). Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis (PubMed:36229594, PubMed:36780110). {ECO:0000250|UniProtKB:Q91VN6, ECO:0000269|PubMed:23222971, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:33650667, ECO:0000269|PubMed:34473945, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:36229594, ECO:0000269|PubMed:36780110}. |
| Q9UKX2 | MYH2 | S1341 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULH1 | ASAP1 | S305 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9ULI0 | ATAD2B | S939 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9UNH7 | SNX6 | S316 | ochoa | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). {ECO:0000250|UniProtKB:Q6P8X1, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:19935774, ECO:0000303|PubMed:20830743, ECO:0000305}. |
| Q9UNS1 | TIMELESS | S105 | ochoa | Protein timeless homolog (hTIM) | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}. |
| Q9UP95 | SLC12A4 | S88 | ochoa | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}. |
| Q9UPN3 | MACF1 | S5808 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPZ3 | HPS5 | S433 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
| Q9UQE7 | SMC3 | S787 | ochoa|psp | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
| Q9Y2K6 | USP20 | S263 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y4D8 | HECTD4 | S1716 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q9Y4J8 | DTNA | S637 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y5Y4 | PTGDR2 | S339 | ochoa | Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}. |
| Q9Y678 | COPG1 | S554 | ochoa | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269|PubMed:20674546}. |
| O43175 | PHGDH | S251 | Sugiyama | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| Q08378 | GOLGA3 | S924 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q9BQS8 | FYCO1 | S669 | Sugiyama | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
| P26641 | EEF1G | S25 | Sugiyama | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | Probably plays a role in anchoring the complex to other cellular components. |
| Q8IYE1 | CCDC13 | S680 | Sugiyama | Coiled-coil domain-containing protein 13 | Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia. {ECO:0000269|PubMed:24816561}. |
| Q99615 | DNAJC7 | S88 | Sugiyama | DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2) | Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:12853476, ECO:0000269|PubMed:18620420}. |
| Q9Y3P9 | RABGAP1 | S932 | Sugiyama | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| P61201 | COPS2 | S178 | Sugiyama | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q9Y3P9 | RABGAP1 | T865 | Sugiyama | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| Q14164 | IKBKE | S522 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| Q4V328 | GRIPAP1 | S291 | Sugiyama | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| P17980 | PSMC3 | S170 | Sugiyama | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| O15212 | PFDN6 | S53 | Sugiyama | Prefoldin subunit 6 (Protein Ke2) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q14980 | NUMA1 | S1317 | Sugiyama | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q8N568 | DCLK2 | S442 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q08378 | GOLGA3 | S500 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q99961 | SH3GL1 | S120 | Sugiyama | Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.599048e-09 | 8.119 |
| R-HSA-199991 | Membrane Trafficking | 3.772672e-07 | 6.423 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.633304e-07 | 6.117 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.503725e-06 | 5.823 |
| R-HSA-9646399 | Aggrephagy | 1.733668e-06 | 5.761 |
| R-HSA-9663891 | Selective autophagy | 2.756987e-06 | 5.560 |
| R-HSA-190828 | Gap junction trafficking | 3.349238e-06 | 5.475 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 6.002352e-06 | 5.222 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.063191e-06 | 5.217 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 7.358502e-06 | 5.133 |
| R-HSA-390522 | Striated Muscle Contraction | 9.308002e-06 | 5.031 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 9.103341e-06 | 5.041 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.443587e-05 | 4.841 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.598895e-05 | 4.796 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.293808e-05 | 4.639 |
| R-HSA-1632852 | Macroautophagy | 2.116826e-05 | 4.674 |
| R-HSA-397014 | Muscle contraction | 2.313540e-05 | 4.636 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.883152e-05 | 4.540 |
| R-HSA-9612973 | Autophagy | 4.729931e-05 | 4.325 |
| R-HSA-437239 | Recycling pathway of L1 | 5.441213e-05 | 4.264 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 5.791113e-05 | 4.237 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.096951e-04 | 3.960 |
| R-HSA-190861 | Gap junction assembly | 1.382258e-04 | 3.859 |
| R-HSA-1640170 | Cell Cycle | 1.505162e-04 | 3.822 |
| R-HSA-373760 | L1CAM interactions | 1.722232e-04 | 3.764 |
| R-HSA-69275 | G2/M Transition | 1.786234e-04 | 3.748 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.001223e-04 | 3.699 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.929322e-04 | 3.715 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.379741e-04 | 3.623 |
| R-HSA-68877 | Mitotic Prometaphase | 2.329798e-04 | 3.633 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.379741e-04 | 3.623 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.165404e-04 | 3.664 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.005899e-04 | 3.522 |
| R-HSA-9675108 | Nervous system development | 2.985856e-04 | 3.525 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 3.209990e-04 | 3.493 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.051768e-04 | 3.515 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 3.791965e-04 | 3.421 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 4.131714e-04 | 3.384 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.321790e-04 | 3.364 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.715039e-04 | 3.327 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 5.263043e-04 | 3.279 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 5.327181e-04 | 3.274 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.712898e-04 | 3.243 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.712898e-04 | 3.243 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.644395e-04 | 3.178 |
| R-HSA-9833482 | PKR-mediated signaling | 6.644395e-04 | 3.178 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 7.864212e-04 | 3.104 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 7.864212e-04 | 3.104 |
| R-HSA-445355 | Smooth Muscle Contraction | 8.348353e-04 | 3.078 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.348753e-04 | 3.078 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 9.627324e-04 | 3.016 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.037218e-03 | 2.984 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.037218e-03 | 2.984 |
| R-HSA-68886 | M Phase | 1.050420e-03 | 2.979 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.128699e-03 | 2.947 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.182277e-03 | 2.927 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.285235e-03 | 2.891 |
| R-HSA-983189 | Kinesins | 1.345842e-03 | 2.871 |
| R-HSA-391251 | Protein folding | 1.408933e-03 | 2.851 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.522728e-03 | 2.817 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.624416e-03 | 2.789 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.941869e-03 | 2.712 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.983234e-03 | 2.703 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.049674e-03 | 2.688 |
| R-HSA-68882 | Mitotic Anaphase | 2.064174e-03 | 2.685 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.123129e-03 | 2.673 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.177753e-03 | 2.662 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.344715e-03 | 2.630 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.400975e-03 | 2.620 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.711206e-03 | 2.567 |
| R-HSA-422475 | Axon guidance | 2.995834e-03 | 2.523 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.274778e-03 | 2.485 |
| R-HSA-5617833 | Cilium Assembly | 3.533760e-03 | 2.452 |
| R-HSA-75153 | Apoptotic execution phase | 3.982783e-03 | 2.400 |
| R-HSA-5620924 | Intraflagellar transport | 4.524146e-03 | 2.344 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.654922e-03 | 2.177 |
| R-HSA-196025 | Formation of annular gap junctions | 7.616677e-03 | 2.118 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 7.179359e-03 | 2.144 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.443592e-03 | 2.128 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 8.421005e-03 | 2.075 |
| R-HSA-190873 | Gap junction degradation | 8.995316e-03 | 2.046 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.021670e-02 | 1.991 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.021670e-02 | 1.991 |
| R-HSA-373755 | Semaphorin interactions | 1.021670e-02 | 1.991 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.202227e-02 | 1.920 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.045149e-02 | 1.981 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.047631e-02 | 1.980 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.122178e-02 | 1.950 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 1.204807e-02 | 1.919 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.121487e-02 | 1.950 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.339478e-02 | 1.873 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.420197e-02 | 1.848 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.582736e-02 | 1.801 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.665974e-02 | 1.778 |
| R-HSA-380287 | Centrosome maturation | 1.714108e-02 | 1.766 |
| R-HSA-5357801 | Programmed Cell Death | 1.771857e-02 | 1.752 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.782272e-02 | 1.749 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.983820e-02 | 1.702 |
| R-HSA-109581 | Apoptosis | 2.029649e-02 | 1.693 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.137797e-02 | 1.670 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 2.320194e-02 | 1.634 |
| R-HSA-5657560 | Hereditary fructose intolerance | 2.320194e-02 | 1.634 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.733024e-02 | 1.563 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.009969e-02 | 1.521 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.039003e-02 | 1.517 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.789377e-02 | 1.554 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.435986e-02 | 1.464 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 3.460131e-02 | 1.461 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.460131e-02 | 1.461 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.536575e-02 | 1.451 |
| R-HSA-1221632 | Meiotic synapsis | 3.580582e-02 | 1.446 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.796366e-02 | 1.421 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.938622e-02 | 1.405 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 4.063224e-02 | 1.391 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.189798e-02 | 1.378 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.239487e-02 | 1.373 |
| R-HSA-9609690 | HCMV Early Events | 4.246969e-02 | 1.372 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 4.586834e-02 | 1.338 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 4.586834e-02 | 1.338 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 4.586834e-02 | 1.338 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 4.586834e-02 | 1.338 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.759247e-02 | 1.322 |
| R-HSA-70635 | Urea cycle | 5.496688e-02 | 1.260 |
| R-HSA-69242 | S Phase | 4.720263e-02 | 1.326 |
| R-HSA-3214842 | HDMs demethylate histones | 5.197403e-02 | 1.284 |
| R-HSA-1500931 | Cell-Cell communication | 4.601639e-02 | 1.337 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.904228e-02 | 1.309 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.904228e-02 | 1.309 |
| R-HSA-6798695 | Neutrophil degranulation | 5.687350e-02 | 1.245 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 5.700456e-02 | 1.244 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.724246e-02 | 1.242 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.742726e-02 | 1.241 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 5.801902e-02 | 1.236 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 5.801902e-02 | 1.236 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.228172e-02 | 1.206 |
| R-HSA-446728 | Cell junction organization | 6.330603e-02 | 1.199 |
| R-HSA-9615710 | Late endosomal microautophagy | 6.429411e-02 | 1.192 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 6.801148e-02 | 1.167 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 6.801148e-02 | 1.167 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 7.889060e-02 | 1.103 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 7.889060e-02 | 1.103 |
| R-HSA-9652817 | Signaling by MAPK mutants | 8.964339e-02 | 1.047 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 8.436449e-02 | 1.074 |
| R-HSA-68962 | Activation of the pre-replicative complex | 6.751361e-02 | 1.171 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 8.787425e-02 | 1.056 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 8.089920e-02 | 1.092 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 8.964339e-02 | 1.047 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 8.964339e-02 | 1.047 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.896615e-02 | 1.161 |
| R-HSA-182971 | EGFR downregulation | 7.078550e-02 | 1.150 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 7.099602e-02 | 1.149 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 7.078550e-02 | 1.150 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 7.747989e-02 | 1.111 |
| R-HSA-69206 | G1/S Transition | 8.402648e-02 | 1.076 |
| R-HSA-69481 | G2/M Checkpoints | 8.740148e-02 | 1.058 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.722362e-02 | 1.112 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.722362e-02 | 1.112 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 9.142698e-02 | 1.039 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.002713e-01 | 0.999 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.107758e-01 | 0.956 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.107758e-01 | 0.956 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.107758e-01 | 0.956 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.211583e-01 | 0.917 |
| R-HSA-9613354 | Lipophagy | 1.314202e-01 | 0.881 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.314202e-01 | 0.881 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.415629e-01 | 0.849 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.415629e-01 | 0.849 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.905361e-01 | 0.720 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.999920e-01 | 0.699 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.999920e-01 | 0.699 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.999920e-01 | 0.699 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 2.093380e-01 | 0.679 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.185754e-01 | 0.660 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.456484e-01 | 0.610 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.173794e-01 | 0.930 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.717883e-01 | 0.566 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.717883e-01 | 0.566 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.116340e-01 | 0.674 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.416995e-01 | 0.617 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.809691e-01 | 0.742 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.544638e-01 | 0.594 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.570790e-01 | 0.804 |
| R-HSA-9857492 | Protein lipoylation | 1.999920e-01 | 0.699 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.135654e-01 | 0.945 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.329426e-01 | 0.876 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.329426e-01 | 0.876 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.329426e-01 | 0.876 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.708620e-01 | 0.767 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 1.211583e-01 | 0.917 |
| R-HSA-6783984 | Glycine degradation | 2.185754e-01 | 0.660 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.097847e-01 | 0.959 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.611797e-01 | 0.793 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 9.735748e-02 | 1.012 |
| R-HSA-72172 | mRNA Splicing | 2.697644e-01 | 0.569 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.218942e-01 | 0.914 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.002713e-01 | 0.999 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.212253e-01 | 0.916 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.611797e-01 | 0.793 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.329426e-01 | 0.876 |
| R-HSA-176974 | Unwinding of DNA | 1.314202e-01 | 0.881 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.415629e-01 | 0.849 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.614962e-01 | 0.792 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.614962e-01 | 0.792 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.712895e-01 | 0.766 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.809691e-01 | 0.742 |
| R-HSA-804914 | Transport of fatty acids | 1.905361e-01 | 0.720 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.290081e-01 | 0.889 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.717883e-01 | 0.566 |
| R-HSA-6799198 | Complex I biogenesis | 2.030986e-01 | 0.692 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.185754e-01 | 0.660 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.367294e-01 | 0.626 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.754412e-01 | 0.560 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.093380e-01 | 0.679 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.802997e-01 | 0.552 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.809691e-01 | 0.742 |
| R-HSA-1500620 | Meiosis | 9.735748e-02 | 1.012 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.737332e-01 | 0.760 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.595206e-01 | 0.797 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.515878e-01 | 0.819 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.367294e-01 | 0.626 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.737332e-01 | 0.760 |
| R-HSA-204005 | COPII-mediated vesicle transport | 2.331111e-01 | 0.632 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.415629e-01 | 0.849 |
| R-HSA-5689603 | UCH proteinases | 2.590410e-01 | 0.587 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.529988e-01 | 0.815 |
| R-HSA-68875 | Mitotic Prophase | 2.091632e-01 | 0.680 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.107758e-01 | 0.956 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.999920e-01 | 0.699 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.456484e-01 | 0.610 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.456484e-01 | 0.610 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.107758e-01 | 0.956 |
| R-HSA-69239 | Synthesis of DNA | 1.651620e-01 | 0.782 |
| R-HSA-5693538 | Homology Directed Repair | 2.031447e-01 | 0.692 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.211583e-01 | 0.917 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.415629e-01 | 0.849 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.905361e-01 | 0.720 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.999920e-01 | 0.699 |
| R-HSA-70350 | Fructose catabolism | 2.093380e-01 | 0.679 |
| R-HSA-6811438 | Intra-Golgi traffic | 1.135654e-01 | 0.945 |
| R-HSA-9766229 | Degradation of CDH1 | 1.449041e-01 | 0.839 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.374243e-01 | 0.624 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.374243e-01 | 0.624 |
| R-HSA-177929 | Signaling by EGFR | 1.735947e-01 | 0.760 |
| R-HSA-5619084 | ABC transporter disorders | 2.676991e-01 | 0.572 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.946046e-01 | 0.711 |
| R-HSA-5689877 | Josephin domain DUBs | 1.415629e-01 | 0.849 |
| R-HSA-9755088 | Ribavirin ADME | 2.717883e-01 | 0.566 |
| R-HSA-4086400 | PCP/CE pathway | 2.676991e-01 | 0.572 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.294993e-01 | 0.639 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.456484e-01 | 0.610 |
| R-HSA-9659379 | Sensory processing of sound | 2.720282e-01 | 0.565 |
| R-HSA-8964038 | LDL clearance | 2.802997e-01 | 0.552 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.331111e-01 | 0.632 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.905361e-01 | 0.720 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 1.097847e-01 | 0.959 |
| R-HSA-8854214 | TBC/RABGAPs | 1.212253e-01 | 0.916 |
| R-HSA-2161541 | Abacavir metabolism | 2.631767e-01 | 0.580 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.717883e-01 | 0.566 |
| R-HSA-5652084 | Fructose metabolism | 2.802997e-01 | 0.552 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.245002e-01 | 0.649 |
| R-HSA-75893 | TNF signaling | 1.735947e-01 | 0.760 |
| R-HSA-3371556 | Cellular response to heat stress | 2.121874e-01 | 0.673 |
| R-HSA-1474165 | Reproduction | 2.460214e-01 | 0.609 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.172457e-01 | 0.663 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 1.107758e-01 | 0.956 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 1.314202e-01 | 0.881 |
| R-HSA-977347 | Serine metabolism | 2.717883e-01 | 0.566 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.735947e-01 | 0.760 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.329426e-01 | 0.876 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.547131e-01 | 0.594 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.286205e-01 | 0.891 |
| R-HSA-70263 | Gluconeogenesis | 1.408917e-01 | 0.851 |
| R-HSA-73893 | DNA Damage Bypass | 1.449041e-01 | 0.839 |
| R-HSA-73894 | DNA Repair | 1.615236e-01 | 0.792 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.515878e-01 | 0.819 |
| R-HSA-391908 | Prostanoid ligand receptors | 1.515878e-01 | 0.819 |
| R-HSA-8876725 | Protein methylation | 1.999920e-01 | 0.699 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.093380e-01 | 0.679 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.185754e-01 | 0.660 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.369042e-01 | 0.864 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.069121e-01 | 0.971 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.417418e-01 | 0.617 |
| R-HSA-9678110 | Attachment and Entry | 2.093380e-01 | 0.679 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.331111e-01 | 0.632 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 1.410619e-01 | 0.851 |
| R-HSA-9609646 | HCMV Infection | 1.001641e-01 | 0.999 |
| R-HSA-597592 | Post-translational protein modification | 1.822615e-01 | 0.739 |
| R-HSA-8852135 | Protein ubiquitination | 2.547131e-01 | 0.594 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.185754e-01 | 0.660 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.367294e-01 | 0.626 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.456484e-01 | 0.610 |
| R-HSA-9694614 | Attachment and Entry | 2.717883e-01 | 0.566 |
| R-HSA-114608 | Platelet degranulation | 2.336089e-01 | 0.632 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.093380e-01 | 0.679 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.544638e-01 | 0.594 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.802997e-01 | 0.552 |
| R-HSA-373753 | Nephrin family interactions | 2.544638e-01 | 0.594 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.106269e-01 | 0.956 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.553987e-01 | 0.593 |
| R-HSA-421270 | Cell-cell junction organization | 1.014757e-01 | 0.994 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 2.544638e-01 | 0.594 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.763564e-01 | 0.559 |
| R-HSA-418990 | Adherens junctions interactions | 1.498940e-01 | 0.824 |
| R-HSA-1266738 | Developmental Biology | 1.170643e-01 | 0.932 |
| R-HSA-162582 | Signal Transduction | 1.447484e-01 | 0.839 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.185754e-01 | 0.660 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 1.819556e-01 | 0.740 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.515878e-01 | 0.819 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.809691e-01 | 0.742 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.030986e-01 | 0.692 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.277055e-01 | 0.643 |
| R-HSA-191273 | Cholesterol biosynthesis | 2.676991e-01 | 0.572 |
| R-HSA-6806834 | Signaling by MET | 2.763564e-01 | 0.559 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.905361e-01 | 0.720 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.720282e-01 | 0.565 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.456484e-01 | 0.610 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.633698e-01 | 0.579 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.408917e-01 | 0.851 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 1.819556e-01 | 0.740 |
| R-HSA-913531 | Interferon Signaling | 1.988876e-01 | 0.701 |
| R-HSA-449147 | Signaling by Interleukins | 1.405071e-01 | 0.852 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.806283e-01 | 0.552 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.806283e-01 | 0.552 |
| R-HSA-9664407 | Parasite infection | 2.806283e-01 | 0.552 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.806834e-01 | 0.552 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.838001e-01 | 0.547 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.936505e-01 | 0.532 |
| R-HSA-168256 | Immune System | 2.955148e-01 | 0.529 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.970269e-01 | 0.527 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.979741e-01 | 0.526 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.022787e-01 | 0.520 |
| R-HSA-9620244 | Long-term potentiation | 3.052449e-01 | 0.515 |
| R-HSA-420029 | Tight junction interactions | 3.052449e-01 | 0.515 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.065863e-01 | 0.513 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.092668e-01 | 0.510 |
| R-HSA-3295583 | TRP channels | 3.133674e-01 | 0.504 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.133674e-01 | 0.504 |
| R-HSA-2161522 | Abacavir ADME | 3.133674e-01 | 0.504 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.133674e-01 | 0.504 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.139276e-01 | 0.503 |
| R-HSA-201451 | Signaling by BMP | 3.213953e-01 | 0.493 |
| R-HSA-8949613 | Cristae formation | 3.213953e-01 | 0.493 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.213953e-01 | 0.493 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.213953e-01 | 0.493 |
| R-HSA-264876 | Insulin processing | 3.213953e-01 | 0.493 |
| R-HSA-69306 | DNA Replication | 3.252306e-01 | 0.488 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.252306e-01 | 0.488 |
| R-HSA-73887 | Death Receptor Signaling | 3.284244e-01 | 0.484 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.293299e-01 | 0.482 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.293299e-01 | 0.482 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.371722e-01 | 0.472 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.371722e-01 | 0.472 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.525842e-01 | 0.453 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.525842e-01 | 0.453 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.525842e-01 | 0.453 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.535441e-01 | 0.452 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.601560e-01 | 0.444 |
| R-HSA-69190 | DNA strand elongation | 3.601560e-01 | 0.444 |
| R-HSA-1538133 | G0 and Early G1 | 3.601560e-01 | 0.444 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.676397e-01 | 0.435 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.676397e-01 | 0.435 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.676397e-01 | 0.435 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.676397e-01 | 0.435 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.676397e-01 | 0.435 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.676397e-01 | 0.435 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.676397e-01 | 0.435 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.745391e-01 | 0.427 |
| R-HSA-70171 | Glycolysis | 3.745391e-01 | 0.427 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.750364e-01 | 0.426 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.750364e-01 | 0.426 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.823469e-01 | 0.418 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.823469e-01 | 0.418 |
| R-HSA-5205647 | Mitophagy | 3.823469e-01 | 0.418 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.823469e-01 | 0.418 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.823469e-01 | 0.418 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.823469e-01 | 0.418 |
| R-HSA-5673000 | RAF activation | 3.823469e-01 | 0.418 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.895724e-01 | 0.409 |
| R-HSA-169911 | Regulation of Apoptosis | 3.895724e-01 | 0.409 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.895724e-01 | 0.409 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.919962e-01 | 0.407 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.951447e-01 | 0.403 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.967138e-01 | 0.402 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.967138e-01 | 0.402 |
| R-HSA-111933 | Calmodulin induced events | 3.967138e-01 | 0.402 |
| R-HSA-111997 | CaM pathway | 3.967138e-01 | 0.402 |
| R-HSA-3371511 | HSF1 activation | 3.967138e-01 | 0.402 |
| R-HSA-163560 | Triglyceride catabolism | 3.967138e-01 | 0.402 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.982890e-01 | 0.400 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.993607e-01 | 0.399 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.037721e-01 | 0.394 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.037721e-01 | 0.394 |
| R-HSA-4641258 | Degradation of DVL | 4.037721e-01 | 0.394 |
| R-HSA-4641257 | Degradation of AXIN | 4.037721e-01 | 0.394 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4.037721e-01 | 0.394 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.037721e-01 | 0.394 |
| R-HSA-5688426 | Deubiquitination | 4.040646e-01 | 0.394 |
| R-HSA-611105 | Respiratory electron transport | 4.076952e-01 | 0.390 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.107483e-01 | 0.386 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.107483e-01 | 0.386 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.107483e-01 | 0.386 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.116009e-01 | 0.386 |
| R-HSA-392499 | Metabolism of proteins | 4.123042e-01 | 0.385 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.176432e-01 | 0.379 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.176432e-01 | 0.379 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.176432e-01 | 0.379 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 4.176432e-01 | 0.379 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.176432e-01 | 0.379 |
| R-HSA-69541 | Stabilization of p53 | 4.176432e-01 | 0.379 |
| R-HSA-168249 | Innate Immune System | 4.178979e-01 | 0.379 |
| R-HSA-202403 | TCR signaling | 4.196931e-01 | 0.377 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.244579e-01 | 0.372 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.244579e-01 | 0.372 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.244579e-01 | 0.372 |
| R-HSA-5260271 | Diseases of Immune System | 4.244579e-01 | 0.372 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.244579e-01 | 0.372 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.244579e-01 | 0.372 |
| R-HSA-202433 | Generation of second messenger molecules | 4.244579e-01 | 0.372 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 4.244579e-01 | 0.372 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.311933e-01 | 0.365 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.311933e-01 | 0.365 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.311933e-01 | 0.365 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.311933e-01 | 0.365 |
| R-HSA-9607240 | FLT3 Signaling | 4.311933e-01 | 0.365 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.316836e-01 | 0.365 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.357063e-01 | 0.361 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.378503e-01 | 0.359 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.378503e-01 | 0.359 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.378503e-01 | 0.359 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.378503e-01 | 0.359 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.378503e-01 | 0.359 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.378503e-01 | 0.359 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.378503e-01 | 0.359 |
| R-HSA-983712 | Ion channel transport | 4.417826e-01 | 0.355 |
| R-HSA-111996 | Ca-dependent events | 4.444297e-01 | 0.352 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.479025e-01 | 0.349 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.509326e-01 | 0.346 |
| R-HSA-70326 | Glucose metabolism | 4.553846e-01 | 0.342 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.553846e-01 | 0.342 |
| R-HSA-9907900 | Proteasome assembly | 4.573597e-01 | 0.340 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.573597e-01 | 0.340 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.573597e-01 | 0.340 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.631460e-01 | 0.334 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.637120e-01 | 0.334 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.637120e-01 | 0.334 |
| R-HSA-774815 | Nucleosome assembly | 4.637120e-01 | 0.334 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.637120e-01 | 0.334 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.637120e-01 | 0.334 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.637120e-01 | 0.334 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.637120e-01 | 0.334 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.637120e-01 | 0.334 |
| R-HSA-9824272 | Somitogenesis | 4.637120e-01 | 0.334 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.637120e-01 | 0.334 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.699903e-01 | 0.328 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.699903e-01 | 0.328 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.699903e-01 | 0.328 |
| R-HSA-9675135 | Diseases of DNA repair | 4.699903e-01 | 0.328 |
| R-HSA-109582 | Hemostasis | 4.729256e-01 | 0.325 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.761955e-01 | 0.322 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.761955e-01 | 0.322 |
| R-HSA-6809371 | Formation of the cornified envelope | 4.822637e-01 | 0.317 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 4.883900e-01 | 0.311 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.883900e-01 | 0.311 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.883900e-01 | 0.311 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.883900e-01 | 0.311 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.943809e-01 | 0.306 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 4.943809e-01 | 0.306 |
| R-HSA-3371571 | HSF1-dependent transactivation | 5.003020e-01 | 0.301 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.003020e-01 | 0.301 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.003020e-01 | 0.301 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.046393e-01 | 0.297 |
| R-HSA-72187 | mRNA 3'-end processing | 5.061541e-01 | 0.296 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.061541e-01 | 0.296 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.061541e-01 | 0.296 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.061541e-01 | 0.296 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.119381e-01 | 0.291 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.119381e-01 | 0.291 |
| R-HSA-112316 | Neuronal System | 5.135076e-01 | 0.289 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.176547e-01 | 0.286 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.233046e-01 | 0.281 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.233046e-01 | 0.281 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.288888e-01 | 0.277 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.288888e-01 | 0.277 |
| R-HSA-5578775 | Ion homeostasis | 5.288888e-01 | 0.277 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.344078e-01 | 0.272 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.344078e-01 | 0.272 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.370305e-01 | 0.270 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.370305e-01 | 0.270 |
| R-HSA-8951664 | Neddylation | 5.388141e-01 | 0.269 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.440280e-01 | 0.264 |
| R-HSA-8979227 | Triglyceride metabolism | 5.452537e-01 | 0.263 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.452537e-01 | 0.263 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.505821e-01 | 0.259 |
| R-HSA-351202 | Metabolism of polyamines | 5.505821e-01 | 0.259 |
| R-HSA-379724 | tRNA Aminoacylation | 5.505821e-01 | 0.259 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.558483e-01 | 0.255 |
| R-HSA-112043 | PLC beta mediated events | 5.558483e-01 | 0.255 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.558483e-01 | 0.255 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.610532e-01 | 0.251 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.610532e-01 | 0.251 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.610532e-01 | 0.251 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.661973e-01 | 0.247 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.661973e-01 | 0.247 |
| R-HSA-1643685 | Disease | 5.674788e-01 | 0.246 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.712815e-01 | 0.243 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.743403e-01 | 0.241 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.763064e-01 | 0.239 |
| R-HSA-112040 | G-protein mediated events | 5.861812e-01 | 0.232 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.861812e-01 | 0.232 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.877080e-01 | 0.231 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.909374e-01 | 0.228 |
| R-HSA-5218859 | Regulated Necrosis | 5.910324e-01 | 0.228 |
| R-HSA-1474244 | Extracellular matrix organization | 5.918910e-01 | 0.228 |
| R-HSA-9824446 | Viral Infection Pathways | 5.937135e-01 | 0.226 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.005657e-01 | 0.221 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.005657e-01 | 0.221 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.005657e-01 | 0.221 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.005657e-01 | 0.221 |
| R-HSA-1280218 | Adaptive Immune System | 6.024679e-01 | 0.220 |
| R-HSA-1989781 | PPARA activates gene expression | 6.036677e-01 | 0.219 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.052491e-01 | 0.218 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.052491e-01 | 0.218 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.098779e-01 | 0.215 |
| R-HSA-74259 | Purine catabolism | 6.098779e-01 | 0.215 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.099204e-01 | 0.215 |
| R-HSA-4839726 | Chromatin organization | 6.131679e-01 | 0.212 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.144527e-01 | 0.212 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 6.144527e-01 | 0.212 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.189742e-01 | 0.208 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.189742e-01 | 0.208 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.189742e-01 | 0.208 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 6.189742e-01 | 0.208 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.191590e-01 | 0.208 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.191590e-01 | 0.208 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.234429e-01 | 0.205 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 6.234429e-01 | 0.205 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.365386e-01 | 0.196 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.450163e-01 | 0.190 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.532974e-01 | 0.185 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.572574e-01 | 0.182 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.573655e-01 | 0.182 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.599448e-01 | 0.180 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.613862e-01 | 0.180 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.653600e-01 | 0.177 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.692873e-01 | 0.174 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.692873e-01 | 0.174 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.724547e-01 | 0.172 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.845436e-01 | 0.165 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.870759e-01 | 0.163 |
| R-HSA-9658195 | Leishmania infection | 6.878170e-01 | 0.163 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.878170e-01 | 0.163 |
| R-HSA-73884 | Base Excision Repair | 6.882470e-01 | 0.162 |
| R-HSA-202424 | Downstream TCR signaling | 6.882470e-01 | 0.162 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.919071e-01 | 0.160 |
| R-HSA-375276 | Peptide ligand-binding receptors | 6.948318e-01 | 0.158 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.990996e-01 | 0.155 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.990996e-01 | 0.155 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.061250e-01 | 0.151 |
| R-HSA-1474290 | Collagen formation | 7.061250e-01 | 0.151 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.095763e-01 | 0.149 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.163584e-01 | 0.145 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.196902e-01 | 0.143 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.196902e-01 | 0.143 |
| R-HSA-195721 | Signaling by WNT | 7.228786e-01 | 0.141 |
| R-HSA-5663205 | Infectious disease | 7.231563e-01 | 0.141 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.262373e-01 | 0.139 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.289569e-01 | 0.137 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.294536e-01 | 0.137 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.326323e-01 | 0.135 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.357739e-01 | 0.133 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.357739e-01 | 0.133 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.358370e-01 | 0.133 |
| R-HSA-111885 | Opioid Signalling | 7.419472e-01 | 0.130 |
| R-HSA-6805567 | Keratinization | 7.447800e-01 | 0.128 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.509393e-01 | 0.124 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.567601e-01 | 0.121 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.567601e-01 | 0.121 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.596196e-01 | 0.119 |
| R-HSA-8957322 | Metabolism of steroids | 7.704983e-01 | 0.113 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.707270e-01 | 0.113 |
| R-HSA-72766 | Translation | 7.763336e-01 | 0.110 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.787211e-01 | 0.109 |
| R-HSA-2262752 | Cellular responses to stress | 7.830443e-01 | 0.106 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.864379e-01 | 0.104 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.864379e-01 | 0.104 |
| R-HSA-73886 | Chromosome Maintenance | 7.963121e-01 | 0.099 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.963121e-01 | 0.099 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.978933e-01 | 0.098 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.010776e-01 | 0.096 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.034185e-01 | 0.095 |
| R-HSA-8939211 | ESR-mediated signaling | 8.056768e-01 | 0.094 |
| R-HSA-9679506 | SARS-CoV Infections | 8.090667e-01 | 0.092 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.098158e-01 | 0.092 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.147186e-01 | 0.089 |
| R-HSA-8956319 | Nucleotide catabolism | 8.168999e-01 | 0.088 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.223866e-01 | 0.085 |
| R-HSA-5576891 | Cardiac conduction | 8.232915e-01 | 0.084 |
| R-HSA-9909396 | Circadian clock | 8.253724e-01 | 0.083 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.253724e-01 | 0.083 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.363165e-01 | 0.078 |
| R-HSA-6807070 | PTEN Regulation | 8.411651e-01 | 0.075 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.485202e-01 | 0.071 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.520696e-01 | 0.070 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.533599e-01 | 0.069 |
| R-HSA-166520 | Signaling by NTRKs | 8.589223e-01 | 0.066 |
| R-HSA-9758941 | Gastrulation | 8.605855e-01 | 0.065 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.622293e-01 | 0.064 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.654591e-01 | 0.063 |
| R-HSA-2142753 | Arachidonate metabolism | 8.654591e-01 | 0.063 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.654591e-01 | 0.063 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.674254e-01 | 0.062 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.711993e-01 | 0.060 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.730512e-01 | 0.059 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.747037e-01 | 0.058 |
| R-HSA-877300 | Interferon gamma signaling | 8.761818e-01 | 0.057 |
| R-HSA-8953854 | Metabolism of RNA | 8.795410e-01 | 0.056 |
| R-HSA-418594 | G alpha (i) signalling events | 8.806626e-01 | 0.055 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.938901e-01 | 0.049 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.963811e-01 | 0.048 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.963811e-01 | 0.048 |
| R-HSA-168255 | Influenza Infection | 9.035104e-01 | 0.044 |
| R-HSA-2559583 | Cellular Senescence | 9.046503e-01 | 0.044 |
| R-HSA-382551 | Transport of small molecules | 9.067282e-01 | 0.043 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.126125e-01 | 0.040 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.132997e-01 | 0.039 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.272568e-01 | 0.033 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.274681e-01 | 0.033 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.363710e-01 | 0.029 |
| R-HSA-9748784 | Drug ADME | 9.400498e-01 | 0.027 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.455008e-01 | 0.024 |
| R-HSA-162906 | HIV Infection | 9.461465e-01 | 0.024 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.467847e-01 | 0.024 |
| R-HSA-72312 | rRNA processing | 9.492629e-01 | 0.023 |
| R-HSA-15869 | Metabolism of nucleotides | 9.516262e-01 | 0.022 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.518499e-01 | 0.021 |
| R-HSA-157118 | Signaling by NOTCH | 9.538800e-01 | 0.021 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.550894e-01 | 0.020 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.581209e-01 | 0.019 |
| R-HSA-416476 | G alpha (q) signalling events | 9.653700e-01 | 0.015 |
| R-HSA-500792 | GPCR ligand binding | 9.756601e-01 | 0.011 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.760976e-01 | 0.011 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.767267e-01 | 0.010 |
| R-HSA-372790 | Signaling by GPCR | 9.786774e-01 | 0.009 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.789981e-01 | 0.009 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.805264e-01 | 0.009 |
| R-HSA-388396 | GPCR downstream signalling | 9.850614e-01 | 0.007 |
| R-HSA-8978868 | Fatty acid metabolism | 9.938505e-01 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 9.951689e-01 | 0.002 |
| R-HSA-212436 | Generic Transcription Pathway | 9.985481e-01 | 0.001 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.987641e-01 | 0.001 |
| R-HSA-74160 | Gene expression (Transcription) | 9.996560e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999386e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999964e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.858 | 0.154 | 2 | 0.844 |
DSTYK |
0.845 | 0.148 | 2 | 0.865 |
CLK3 |
0.845 | 0.156 | 1 | 0.849 |
PRKD2 |
0.843 | 0.141 | -3 | 0.723 |
PRKD1 |
0.843 | 0.144 | -3 | 0.764 |
NLK |
0.843 | 0.188 | 1 | 0.883 |
ERK5 |
0.842 | 0.213 | 1 | 0.859 |
PIM3 |
0.840 | 0.065 | -3 | 0.759 |
RAF1 |
0.840 | 0.041 | 1 | 0.855 |
PKN3 |
0.838 | 0.108 | -3 | 0.756 |
CDKL1 |
0.838 | 0.087 | -3 | 0.745 |
IKKB |
0.837 | -0.005 | -2 | 0.700 |
PIM1 |
0.837 | 0.117 | -3 | 0.727 |
ULK2 |
0.837 | -0.012 | 2 | 0.750 |
SRPK1 |
0.837 | 0.125 | -3 | 0.706 |
CAMK1B |
0.837 | 0.046 | -3 | 0.809 |
RSK2 |
0.836 | 0.082 | -3 | 0.722 |
NUAK2 |
0.836 | 0.091 | -3 | 0.784 |
WNK1 |
0.836 | 0.101 | -2 | 0.778 |
PKN2 |
0.835 | 0.111 | -3 | 0.781 |
PRPK |
0.835 | -0.106 | -1 | 0.856 |
MST4 |
0.835 | 0.083 | 2 | 0.847 |
PKCD |
0.834 | 0.127 | 2 | 0.788 |
TBK1 |
0.834 | -0.007 | 1 | 0.795 |
NEK6 |
0.834 | 0.047 | -2 | 0.786 |
CDKL5 |
0.834 | 0.098 | -3 | 0.738 |
GCN2 |
0.834 | -0.082 | 2 | 0.760 |
NEK7 |
0.832 | 0.008 | -3 | 0.766 |
IKKE |
0.831 | -0.001 | 1 | 0.790 |
NIK |
0.831 | 0.076 | -3 | 0.814 |
MTOR |
0.831 | -0.103 | 1 | 0.825 |
TSSK2 |
0.831 | 0.121 | -5 | 0.807 |
AMPKA1 |
0.831 | 0.070 | -3 | 0.789 |
CAMK2G |
0.830 | -0.047 | 2 | 0.733 |
CDC7 |
0.830 | -0.070 | 1 | 0.752 |
BMPR2 |
0.830 | -0.095 | -2 | 0.815 |
P90RSK |
0.830 | 0.046 | -3 | 0.723 |
TSSK1 |
0.829 | 0.110 | -3 | 0.801 |
MLK1 |
0.829 | 0.032 | 2 | 0.814 |
PRKD3 |
0.829 | 0.108 | -3 | 0.719 |
MOS |
0.829 | -0.057 | 1 | 0.813 |
P70S6KB |
0.828 | 0.047 | -3 | 0.746 |
MAPKAPK3 |
0.828 | 0.046 | -3 | 0.726 |
ATR |
0.828 | -0.030 | 1 | 0.827 |
RSK3 |
0.828 | 0.047 | -3 | 0.721 |
PDHK4 |
0.828 | -0.219 | 1 | 0.866 |
SRPK2 |
0.828 | 0.094 | -3 | 0.634 |
ICK |
0.827 | 0.066 | -3 | 0.774 |
NDR1 |
0.827 | -0.014 | -3 | 0.763 |
TGFBR2 |
0.827 | -0.014 | -2 | 0.753 |
IKKA |
0.827 | 0.031 | -2 | 0.685 |
NEK9 |
0.827 | 0.053 | 2 | 0.827 |
NDR2 |
0.827 | -0.053 | -3 | 0.755 |
AMPKA2 |
0.826 | 0.068 | -3 | 0.761 |
MAPKAPK2 |
0.826 | 0.058 | -3 | 0.680 |
CAMLCK |
0.826 | 0.015 | -2 | 0.783 |
MARK4 |
0.826 | 0.021 | 4 | 0.831 |
AURC |
0.826 | 0.074 | -2 | 0.621 |
RIPK3 |
0.826 | -0.026 | 3 | 0.714 |
HUNK |
0.826 | -0.037 | 2 | 0.751 |
PDHK1 |
0.825 | -0.121 | 1 | 0.871 |
ULK1 |
0.825 | -0.086 | -3 | 0.757 |
HIPK4 |
0.824 | 0.050 | 1 | 0.863 |
PKACG |
0.824 | 0.024 | -2 | 0.683 |
PKR |
0.824 | 0.178 | 1 | 0.877 |
WNK3 |
0.823 | -0.085 | 1 | 0.853 |
CLK1 |
0.823 | 0.116 | -3 | 0.718 |
CHAK2 |
0.823 | -0.013 | -1 | 0.865 |
SKMLCK |
0.823 | -0.012 | -2 | 0.762 |
PKCB |
0.823 | 0.103 | 2 | 0.761 |
NUAK1 |
0.823 | 0.049 | -3 | 0.741 |
IRE1 |
0.822 | 0.050 | 1 | 0.844 |
MELK |
0.822 | 0.060 | -3 | 0.752 |
SRPK3 |
0.822 | 0.086 | -3 | 0.676 |
CDK8 |
0.822 | 0.081 | 1 | 0.737 |
GRK6 |
0.822 | 0.016 | 1 | 0.797 |
KIS |
0.822 | 0.061 | 1 | 0.771 |
PKACB |
0.822 | 0.076 | -2 | 0.633 |
IRE2 |
0.821 | 0.068 | 2 | 0.753 |
CLK4 |
0.821 | 0.088 | -3 | 0.729 |
CLK2 |
0.821 | 0.144 | -3 | 0.705 |
JNK2 |
0.821 | 0.162 | 1 | 0.695 |
DAPK2 |
0.821 | -0.023 | -3 | 0.803 |
CAMK2D |
0.821 | -0.032 | -3 | 0.775 |
CDK5 |
0.820 | 0.139 | 1 | 0.759 |
FAM20C |
0.820 | 0.055 | 2 | 0.564 |
PLK1 |
0.820 | 0.016 | -2 | 0.767 |
DYRK2 |
0.820 | 0.095 | 1 | 0.789 |
PAK1 |
0.820 | 0.012 | -2 | 0.710 |
LATS2 |
0.819 | -0.042 | -5 | 0.648 |
ANKRD3 |
0.819 | -0.019 | 1 | 0.889 |
MNK2 |
0.819 | 0.039 | -2 | 0.727 |
MLK2 |
0.819 | -0.025 | 2 | 0.800 |
NEK2 |
0.819 | 0.075 | 2 | 0.814 |
JNK3 |
0.819 | 0.143 | 1 | 0.724 |
AURB |
0.818 | 0.051 | -2 | 0.619 |
MLK3 |
0.818 | 0.040 | 2 | 0.751 |
PKCA |
0.818 | 0.087 | 2 | 0.756 |
RSK4 |
0.818 | 0.053 | -3 | 0.678 |
CAMK2B |
0.818 | 0.013 | 2 | 0.702 |
PIM2 |
0.817 | 0.091 | -3 | 0.707 |
PRKX |
0.817 | 0.090 | -3 | 0.634 |
PKCG |
0.817 | 0.057 | 2 | 0.744 |
CAMK4 |
0.817 | -0.030 | -3 | 0.763 |
NIM1 |
0.817 | -0.051 | 3 | 0.762 |
GRK1 |
0.817 | -0.020 | -2 | 0.695 |
DLK |
0.817 | -0.095 | 1 | 0.825 |
PKCH |
0.816 | 0.067 | 2 | 0.735 |
CDK19 |
0.816 | 0.083 | 1 | 0.704 |
AKT2 |
0.816 | 0.066 | -3 | 0.659 |
PAK3 |
0.816 | -0.016 | -2 | 0.713 |
GRK5 |
0.816 | -0.179 | -3 | 0.773 |
P38A |
0.816 | 0.127 | 1 | 0.790 |
MLK4 |
0.816 | 0.055 | 2 | 0.731 |
PAK6 |
0.816 | 0.053 | -2 | 0.666 |
PKCZ |
0.815 | 0.064 | 2 | 0.793 |
BCKDK |
0.815 | -0.132 | -1 | 0.793 |
CDK13 |
0.815 | 0.096 | 1 | 0.720 |
SGK3 |
0.815 | 0.069 | -3 | 0.714 |
MSK2 |
0.815 | -0.008 | -3 | 0.694 |
SIK |
0.815 | 0.029 | -3 | 0.716 |
BMPR1B |
0.815 | 0.064 | 1 | 0.702 |
QSK |
0.815 | 0.031 | 4 | 0.804 |
LATS1 |
0.814 | 0.009 | -3 | 0.760 |
PHKG1 |
0.814 | 0.030 | -3 | 0.760 |
CDK1 |
0.814 | 0.101 | 1 | 0.689 |
PKG2 |
0.814 | 0.048 | -2 | 0.640 |
CHK1 |
0.813 | 0.041 | -3 | 0.760 |
HIPK1 |
0.813 | 0.115 | 1 | 0.804 |
MNK1 |
0.813 | 0.040 | -2 | 0.737 |
RIPK1 |
0.813 | -0.123 | 1 | 0.854 |
ATM |
0.813 | -0.035 | 1 | 0.760 |
ERK1 |
0.813 | 0.118 | 1 | 0.715 |
CDK18 |
0.813 | 0.108 | 1 | 0.680 |
CDK7 |
0.812 | 0.061 | 1 | 0.739 |
ALK4 |
0.812 | -0.007 | -2 | 0.782 |
QIK |
0.812 | -0.035 | -3 | 0.773 |
CAMK2A |
0.812 | -0.007 | 2 | 0.712 |
P38B |
0.811 | 0.123 | 1 | 0.717 |
P38G |
0.811 | 0.123 | 1 | 0.618 |
MSK1 |
0.811 | 0.019 | -3 | 0.701 |
MASTL |
0.811 | -0.271 | -2 | 0.727 |
YSK4 |
0.811 | -0.022 | 1 | 0.798 |
AKT1 |
0.811 | 0.090 | -3 | 0.670 |
TGFBR1 |
0.811 | 0.021 | -2 | 0.759 |
CDK2 |
0.811 | 0.071 | 1 | 0.762 |
CAMK1G |
0.810 | 0.023 | -3 | 0.715 |
ERK7 |
0.810 | 0.230 | 2 | 0.668 |
MYLK4 |
0.810 | 0.006 | -2 | 0.704 |
HIPK2 |
0.810 | 0.104 | 1 | 0.707 |
PLK3 |
0.810 | -0.016 | 2 | 0.686 |
ERK2 |
0.810 | 0.100 | 1 | 0.748 |
MARK3 |
0.809 | 0.032 | 4 | 0.779 |
TTBK2 |
0.809 | -0.153 | 2 | 0.655 |
PINK1 |
0.809 | 0.003 | 1 | 0.883 |
CDK9 |
0.809 | 0.086 | 1 | 0.731 |
CHAK1 |
0.808 | -0.043 | 2 | 0.736 |
BRAF |
0.808 | 0.022 | -4 | 0.781 |
SSTK |
0.808 | 0.083 | 4 | 0.787 |
PHKG2 |
0.808 | 0.068 | -3 | 0.759 |
CDK12 |
0.808 | 0.088 | 1 | 0.699 |
P38D |
0.808 | 0.158 | 1 | 0.644 |
VRK2 |
0.808 | -0.102 | 1 | 0.894 |
CDK10 |
0.807 | 0.153 | 1 | 0.716 |
DNAPK |
0.807 | -0.002 | 1 | 0.748 |
MARK2 |
0.807 | 0.013 | 4 | 0.737 |
DYRK1A |
0.806 | 0.067 | 1 | 0.810 |
PERK |
0.806 | -0.022 | -2 | 0.782 |
ALK2 |
0.806 | 0.020 | -2 | 0.771 |
HRI |
0.806 | -0.046 | -2 | 0.778 |
PAK2 |
0.806 | -0.054 | -2 | 0.699 |
NEK5 |
0.806 | 0.054 | 1 | 0.874 |
PKCT |
0.806 | 0.056 | 2 | 0.742 |
GRK4 |
0.806 | -0.174 | -2 | 0.727 |
IRAK4 |
0.806 | 0.031 | 1 | 0.855 |
CDK16 |
0.806 | 0.132 | 1 | 0.641 |
GRK7 |
0.805 | -0.014 | 1 | 0.742 |
PKACA |
0.805 | 0.050 | -2 | 0.593 |
AURA |
0.805 | 0.006 | -2 | 0.592 |
BRSK1 |
0.805 | -0.037 | -3 | 0.740 |
CDK17 |
0.805 | 0.086 | 1 | 0.623 |
DCAMKL1 |
0.805 | 0.005 | -3 | 0.737 |
CDK14 |
0.805 | 0.112 | 1 | 0.729 |
HIPK3 |
0.804 | 0.084 | 1 | 0.821 |
MST3 |
0.804 | 0.067 | 2 | 0.840 |
P70S6K |
0.804 | 0.021 | -3 | 0.671 |
WNK4 |
0.804 | -0.023 | -2 | 0.767 |
MEKK1 |
0.804 | -0.005 | 1 | 0.853 |
ACVR2A |
0.804 | -0.023 | -2 | 0.745 |
PKCI |
0.803 | 0.089 | 2 | 0.770 |
CAMKK1 |
0.803 | 0.129 | -2 | 0.773 |
BRSK2 |
0.803 | -0.059 | -3 | 0.762 |
MEK1 |
0.803 | -0.185 | 2 | 0.767 |
DYRK3 |
0.803 | 0.080 | 1 | 0.815 |
TLK2 |
0.803 | -0.086 | 1 | 0.835 |
CDK3 |
0.803 | 0.102 | 1 | 0.638 |
ACVR2B |
0.803 | -0.021 | -2 | 0.753 |
MARK1 |
0.802 | -0.012 | 4 | 0.798 |
PRP4 |
0.802 | 0.026 | -3 | 0.690 |
DYRK1B |
0.801 | 0.073 | 1 | 0.740 |
DYRK4 |
0.801 | 0.084 | 1 | 0.706 |
SMG1 |
0.800 | -0.079 | 1 | 0.785 |
MEKK2 |
0.800 | -0.042 | 2 | 0.774 |
SMMLCK |
0.799 | -0.006 | -3 | 0.765 |
CAMK1D |
0.799 | 0.028 | -3 | 0.655 |
MAPKAPK5 |
0.799 | -0.090 | -3 | 0.670 |
CAMKK2 |
0.798 | 0.098 | -2 | 0.766 |
ZAK |
0.798 | -0.073 | 1 | 0.801 |
TAO3 |
0.798 | -0.002 | 1 | 0.822 |
GAK |
0.798 | 0.100 | 1 | 0.865 |
PKCE |
0.798 | 0.085 | 2 | 0.741 |
PKN1 |
0.798 | 0.075 | -3 | 0.692 |
SNRK |
0.798 | -0.145 | 2 | 0.636 |
CDK6 |
0.798 | 0.144 | 1 | 0.715 |
NEK8 |
0.797 | 0.015 | 2 | 0.813 |
AKT3 |
0.797 | 0.066 | -3 | 0.598 |
BMPR1A |
0.797 | 0.033 | 1 | 0.673 |
PLK4 |
0.797 | -0.112 | 2 | 0.551 |
DRAK1 |
0.797 | -0.089 | 1 | 0.722 |
MEK5 |
0.796 | -0.179 | 2 | 0.779 |
DCAMKL2 |
0.796 | -0.024 | -3 | 0.767 |
BUB1 |
0.796 | 0.163 | -5 | 0.774 |
MEKK3 |
0.796 | -0.149 | 1 | 0.830 |
NEK4 |
0.795 | 0.071 | 1 | 0.855 |
TLK1 |
0.794 | -0.104 | -2 | 0.747 |
TAO2 |
0.794 | 0.016 | 2 | 0.837 |
CDK4 |
0.794 | 0.129 | 1 | 0.686 |
MAK |
0.794 | 0.108 | -2 | 0.676 |
MRCKB |
0.794 | 0.064 | -3 | 0.700 |
GSK3B |
0.794 | 0.005 | 4 | 0.451 |
GRK2 |
0.793 | -0.106 | -2 | 0.641 |
LKB1 |
0.793 | 0.039 | -3 | 0.750 |
CHK2 |
0.793 | 0.043 | -3 | 0.620 |
PAK5 |
0.793 | -0.014 | -2 | 0.589 |
MPSK1 |
0.793 | 0.015 | 1 | 0.855 |
HGK |
0.793 | 0.068 | 3 | 0.862 |
SGK1 |
0.792 | 0.047 | -3 | 0.582 |
TNIK |
0.792 | 0.078 | 3 | 0.860 |
GSK3A |
0.792 | 0.023 | 4 | 0.462 |
CAMK1A |
0.792 | 0.053 | -3 | 0.633 |
MST2 |
0.792 | 0.023 | 1 | 0.840 |
JNK1 |
0.792 | 0.097 | 1 | 0.666 |
MOK |
0.791 | 0.118 | 1 | 0.827 |
EEF2K |
0.791 | 0.064 | 3 | 0.851 |
MINK |
0.791 | 0.053 | 1 | 0.849 |
DAPK3 |
0.790 | 0.005 | -3 | 0.745 |
LOK |
0.790 | 0.037 | -2 | 0.703 |
ROCK2 |
0.789 | 0.069 | -3 | 0.734 |
NEK1 |
0.789 | 0.079 | 1 | 0.853 |
MRCKA |
0.789 | 0.038 | -3 | 0.707 |
GCK |
0.789 | 0.012 | 1 | 0.841 |
PASK |
0.789 | -0.067 | -3 | 0.768 |
TAK1 |
0.788 | 0.029 | 1 | 0.849 |
PAK4 |
0.788 | -0.013 | -2 | 0.597 |
IRAK1 |
0.788 | -0.146 | -1 | 0.758 |
CK1E |
0.787 | -0.085 | -3 | 0.508 |
PLK2 |
0.787 | 0.025 | -3 | 0.760 |
PDK1 |
0.786 | -0.056 | 1 | 0.850 |
KHS2 |
0.786 | 0.107 | 1 | 0.852 |
SBK |
0.785 | 0.041 | -3 | 0.555 |
LRRK2 |
0.785 | -0.010 | 2 | 0.829 |
NEK11 |
0.785 | -0.134 | 1 | 0.834 |
KHS1 |
0.785 | 0.081 | 1 | 0.847 |
MEKK6 |
0.784 | -0.040 | 1 | 0.826 |
DMPK1 |
0.784 | 0.084 | -3 | 0.718 |
HPK1 |
0.784 | 0.027 | 1 | 0.834 |
MST1 |
0.784 | -0.005 | 1 | 0.836 |
TTBK1 |
0.783 | -0.155 | 2 | 0.564 |
SLK |
0.783 | -0.009 | -2 | 0.636 |
ROCK1 |
0.782 | 0.071 | -3 | 0.709 |
VRK1 |
0.782 | -0.060 | 2 | 0.809 |
YSK1 |
0.781 | 0.034 | 2 | 0.819 |
CK1G1 |
0.781 | -0.095 | -3 | 0.499 |
DAPK1 |
0.780 | -0.024 | -3 | 0.733 |
CK1D |
0.780 | -0.076 | -3 | 0.459 |
PBK |
0.780 | 0.056 | 1 | 0.815 |
MAP3K15 |
0.779 | -0.091 | 1 | 0.799 |
GRK3 |
0.778 | -0.111 | -2 | 0.594 |
CK1A2 |
0.778 | -0.077 | -3 | 0.462 |
PKG1 |
0.777 | 0.002 | -2 | 0.576 |
CRIK |
0.776 | 0.048 | -3 | 0.660 |
CK2A2 |
0.776 | -0.012 | 1 | 0.571 |
TTK |
0.776 | 0.023 | -2 | 0.760 |
NEK3 |
0.775 | -0.034 | 1 | 0.822 |
STK33 |
0.775 | -0.127 | 2 | 0.547 |
BIKE |
0.774 | 0.115 | 1 | 0.771 |
MYO3B |
0.771 | 0.061 | 2 | 0.823 |
OSR1 |
0.771 | -0.029 | 2 | 0.774 |
RIPK2 |
0.770 | -0.197 | 1 | 0.778 |
MEK2 |
0.768 | -0.223 | 2 | 0.746 |
HASPIN |
0.766 | -0.001 | -1 | 0.714 |
MYO3A |
0.766 | 0.009 | 1 | 0.847 |
PDHK3_TYR |
0.764 | 0.106 | 4 | 0.878 |
CK2A1 |
0.763 | -0.039 | 1 | 0.544 |
TAO1 |
0.763 | -0.025 | 1 | 0.780 |
AAK1 |
0.760 | 0.142 | 1 | 0.685 |
ALPHAK3 |
0.757 | -0.071 | -1 | 0.795 |
ASK1 |
0.755 | -0.128 | 1 | 0.777 |
PDHK4_TYR |
0.755 | -0.002 | 2 | 0.816 |
TESK1_TYR |
0.755 | -0.073 | 3 | 0.867 |
YANK3 |
0.753 | -0.094 | 2 | 0.341 |
BMPR2_TYR |
0.752 | -0.014 | -1 | 0.878 |
MAP2K6_TYR |
0.752 | -0.069 | -1 | 0.887 |
PINK1_TYR |
0.752 | -0.072 | 1 | 0.837 |
LIMK2_TYR |
0.752 | 0.000 | -3 | 0.811 |
MAP2K4_TYR |
0.751 | -0.137 | -1 | 0.875 |
PKMYT1_TYR |
0.751 | -0.090 | 3 | 0.817 |
MAP2K7_TYR |
0.750 | -0.221 | 2 | 0.797 |
RET |
0.750 | -0.050 | 1 | 0.840 |
TYK2 |
0.749 | -0.011 | 1 | 0.846 |
STLK3 |
0.748 | -0.149 | 1 | 0.779 |
PDHK1_TYR |
0.746 | -0.144 | -1 | 0.895 |
EPHA6 |
0.745 | 0.006 | -1 | 0.865 |
TNNI3K_TYR |
0.743 | 0.085 | 1 | 0.865 |
LIMK1_TYR |
0.743 | -0.142 | 2 | 0.812 |
JAK2 |
0.743 | -0.066 | 1 | 0.840 |
ROS1 |
0.742 | -0.069 | 3 | 0.751 |
MST1R |
0.742 | -0.108 | 3 | 0.776 |
DDR1 |
0.740 | -0.126 | 4 | 0.794 |
EPHB4 |
0.740 | -0.066 | -1 | 0.838 |
TYRO3 |
0.739 | -0.127 | 3 | 0.776 |
JAK3 |
0.738 | -0.064 | 1 | 0.794 |
ABL2 |
0.738 | -0.035 | -1 | 0.800 |
CSF1R |
0.738 | -0.086 | 3 | 0.752 |
NEK10_TYR |
0.737 | -0.035 | 1 | 0.714 |
CK1A |
0.736 | -0.123 | -3 | 0.374 |
INSRR |
0.736 | -0.074 | 3 | 0.727 |
FLT3 |
0.736 | -0.059 | 3 | 0.760 |
PDGFRB |
0.735 | -0.094 | 3 | 0.777 |
JAK1 |
0.734 | -0.006 | 1 | 0.796 |
YES1 |
0.734 | -0.092 | -1 | 0.815 |
ABL1 |
0.733 | -0.063 | -1 | 0.787 |
TNK1 |
0.732 | -0.083 | 3 | 0.741 |
FGR |
0.732 | -0.133 | 1 | 0.846 |
FGFR2 |
0.732 | -0.131 | 3 | 0.767 |
FER |
0.731 | -0.157 | 1 | 0.820 |
KDR |
0.731 | -0.091 | 3 | 0.710 |
TXK |
0.731 | -0.046 | 1 | 0.750 |
LCK |
0.731 | -0.021 | -1 | 0.810 |
TNK2 |
0.731 | -0.097 | 3 | 0.716 |
HCK |
0.730 | -0.089 | -1 | 0.807 |
BLK |
0.729 | -0.001 | -1 | 0.821 |
ITK |
0.729 | -0.086 | -1 | 0.782 |
EPHB1 |
0.729 | -0.107 | 1 | 0.803 |
WEE1_TYR |
0.729 | -0.046 | -1 | 0.736 |
CK1G3 |
0.728 | -0.091 | -3 | 0.328 |
KIT |
0.728 | -0.134 | 3 | 0.756 |
EPHA4 |
0.728 | -0.106 | 2 | 0.694 |
FGFR1 |
0.728 | -0.138 | 3 | 0.737 |
DDR2 |
0.726 | -0.042 | 3 | 0.712 |
EPHB2 |
0.726 | -0.102 | -1 | 0.821 |
SRMS |
0.726 | -0.149 | 1 | 0.794 |
EPHB3 |
0.726 | -0.125 | -1 | 0.817 |
PDGFRA |
0.724 | -0.175 | 3 | 0.770 |
BMX |
0.724 | -0.076 | -1 | 0.704 |
TEK |
0.724 | -0.178 | 3 | 0.705 |
TEC |
0.724 | -0.099 | -1 | 0.709 |
ALK |
0.723 | -0.120 | 3 | 0.687 |
AXL |
0.722 | -0.176 | 3 | 0.747 |
LTK |
0.722 | -0.128 | 3 | 0.695 |
MET |
0.721 | -0.151 | 3 | 0.744 |
BTK |
0.721 | -0.173 | -1 | 0.730 |
MERTK |
0.721 | -0.156 | 3 | 0.730 |
FLT1 |
0.720 | -0.130 | -1 | 0.850 |
INSR |
0.719 | -0.130 | 3 | 0.701 |
FYN |
0.719 | -0.053 | -1 | 0.785 |
PTK6 |
0.719 | -0.200 | -1 | 0.698 |
FGFR3 |
0.719 | -0.154 | 3 | 0.736 |
YANK2 |
0.718 | -0.124 | 2 | 0.356 |
NTRK1 |
0.718 | -0.192 | -1 | 0.814 |
FLT4 |
0.717 | -0.163 | 3 | 0.702 |
NTRK2 |
0.716 | -0.177 | 3 | 0.717 |
ERBB2 |
0.716 | -0.184 | 1 | 0.761 |
FRK |
0.716 | -0.123 | -1 | 0.821 |
EPHA7 |
0.716 | -0.136 | 2 | 0.705 |
EPHA1 |
0.715 | -0.161 | 3 | 0.725 |
EPHA3 |
0.714 | -0.168 | 2 | 0.670 |
MATK |
0.714 | -0.136 | -1 | 0.740 |
LYN |
0.711 | -0.131 | 3 | 0.666 |
EGFR |
0.710 | -0.102 | 1 | 0.660 |
EPHA5 |
0.709 | -0.131 | 2 | 0.678 |
NTRK3 |
0.709 | -0.173 | -1 | 0.761 |
FGFR4 |
0.708 | -0.126 | -1 | 0.775 |
CSK |
0.706 | -0.178 | 2 | 0.704 |
PTK2B |
0.706 | -0.153 | -1 | 0.750 |
PTK2 |
0.706 | -0.051 | -1 | 0.812 |
SRC |
0.705 | -0.134 | -1 | 0.773 |
EPHA8 |
0.705 | -0.148 | -1 | 0.797 |
MUSK |
0.704 | -0.113 | 1 | 0.667 |
CK1G2 |
0.703 | -0.114 | -3 | 0.418 |
SYK |
0.702 | -0.078 | -1 | 0.795 |
IGF1R |
0.701 | -0.149 | 3 | 0.635 |
EPHA2 |
0.695 | -0.146 | -1 | 0.775 |
ERBB4 |
0.692 | -0.119 | 1 | 0.657 |
ZAP70 |
0.679 | -0.116 | -1 | 0.717 |
FES |
0.678 | -0.207 | -1 | 0.676 |