Motif 712 (n=115)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O14628 | ZNF195 | S394 | ochoa | Zinc finger protein 195 | May be involved in transcriptional regulation. |
| O14974 | PPP1R12A | S473 | ochoa|psp | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O15061 | SYNM | S489 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O43175 | PHGDH | S55 | ochoa|psp | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| O43379 | WDR62 | S614 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O60563 | CCNT1 | S495 | ochoa | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O60566 | BUB1B | S525 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O75376 | NCOR1 | S1322 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O95229 | ZWINT | S81 | ochoa | Outer kinetochore KNL1 complex subunit ZWINT (ZW10 interactor) (ZW10-interacting protein 1) (Zwint-1) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15094189, PubMed:15485811, PubMed:15824131, PubMed:16732327, PubMed:24530301, PubMed:27881301, PubMed:38459127, PubMed:38459128). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:15094189, PubMed:15485811, PubMed:16732327). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:15094189, PubMed:15485811, PubMed:15824131, PubMed:16732327, PubMed:24530301, PubMed:38459127, PubMed:38459128). Targets the RZZ complex to the kinetochore at prometaphase (PubMed:15485811). Recruits MAD2L1 to the kinetochore, but is not required for BUB1B localization (By similarity). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (PubMed:15485811). {ECO:0000250|UniProtKB:Q9CQU5, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:24530301, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| P00390 | GSR | S444 | ochoa | Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7) | Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol. {ECO:0000269|PubMed:17185460}. |
| P00390 | GSR | S446 | ochoa | Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7) | Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol. {ECO:0000269|PubMed:17185460}. |
| P08047 | SP1 | S670 | ochoa|psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08047 | SP1 | S698 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P0CG40 | SP9 | S376 | ochoa | Transcription factor Sp9 | Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). {ECO:0000250}. |
| P10636 | MAPT | S369 | psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P17028 | ZNF24 | S291 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P17029 | ZKSCAN1 | S445 | ochoa | Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) | May be involved in transcriptional regulation. |
| P17097 | ZNF7 | S397 | ochoa | Zinc finger protein 7 (Zinc finger protein HF.16) (Zinc finger protein KOX4) | May be involved in transcriptional regulation. |
| P18859 | ATP5PF | S65 | ochoa | ATP synthase peripheral stalk subunit F6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6) | Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P02721, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P18887 | XRCC1 | S371 | psp | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P19429 | TNNI3 | S166 | psp | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P20810 | CAST | S373 | ochoa|psp | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21127 | CDK11B | S113 | ochoa | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P26358 | DNMT1 | S1105 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P27815 | PDE4A | S628 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P35716 | SOX11 | S71 | ochoa | Transcription factor SOX-11 | Transcription factor that acts as a transcriptional activator (PubMed:24886874, PubMed:26543203). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). {ECO:0000250|UniProtKB:Q7M6Y2, ECO:0000269|PubMed:24886874, ECO:0000269|PubMed:26543203}. |
| P49756 | RBM25 | S226 | ochoa | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}. |
| P49792 | RANBP2 | S2606 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51955 | NEK2 | S397 | ochoa | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P52737 | ZNF136 | S292 | ochoa | Zinc finger protein 136 | May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain. |
| P59923 | ZNF445 | S665 | ochoa | Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15) | Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). {ECO:0000269|PubMed:30602440}. |
| P62280 | RPS11 | S67 | ochoa | Small ribosomal subunit protein uS17 (40S ribosomal protein S11) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P78371 | CCT2 | S260 | ochoa|psp | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P78545 | ELF3 | S68 | psp | ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) | Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:10644990, ECO:0000269|PubMed:10773884, ECO:0000269|PubMed:11036073, ECO:0000269|PubMed:11313868, ECO:0000269|PubMed:12414801, ECO:0000269|PubMed:12624109, ECO:0000269|PubMed:12682075, ECO:0000269|PubMed:12713734, ECO:0000269|PubMed:14715662, ECO:0000269|PubMed:14767472, ECO:0000269|PubMed:15075319, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:15794755, ECO:0000269|PubMed:16307850, ECO:0000269|PubMed:17060315, ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241, ECO:0000269|PubMed:9417054}. |
| Q01082 | SPTBN1 | S2341 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01831 | XPC | S903 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q02086 | SP2 | S569 | ochoa | Transcription factor Sp2 | Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. |
| Q02446 | SP4 | S691 | ochoa | Transcription factor Sp4 (SPR-1) | Binds to GT and GC boxes promoters elements. Probable transcriptional activator. |
| Q02447 | SP3 | S665 | ochoa | Transcription factor Sp3 (SPR-2) | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}. |
| Q04206 | RELA | S42 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q06787 | FMR1 | S603 | ochoa | Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) | Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs (PubMed:12417522, PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:12417522, PubMed:30765518, PubMed:31439799). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with CAPRIN1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). Acts as a repressor of mRNA translation in synaptic regions by mediating formation of neuronal ribonucleoprotein granules and promoting recruitmtent of EIF4EBP2 (PubMed:30765518). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postsynaptic dendritic spines (PubMed:11157796, PubMed:11532944, PubMed:12594214, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes (PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:14703574, PubMed:17057366, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (PubMed:17057366). Also plays a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:19097999, PubMed:19166269). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:11157796, PubMed:11719189, PubMed:12594214, PubMed:17417632, PubMed:23235829, PubMed:24448548, PubMed:7692601). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (PubMed:23235829). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:11719189, PubMed:18579868, PubMed:25464849, PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (PubMed:11532944, PubMed:12594214, PubMed:15282548, PubMed:18653529, PubMed:7692601). Also binds to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (PubMed:15805463). Binds mRNAs containing U-rich target sequences (PubMed:12927206). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Plays a role in mRNA nuclear export (PubMed:31753916). Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs, promoting their nuclear export in a XPO1/CRM1-dependent manner (PubMed:31753916). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain (PubMed:14703574, PubMed:17057366). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (PubMed:18936162). In vitro, binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:12950170, PubMed:15381419, PubMed:7688265, PubMed:7781595, PubMed:8156595). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteasomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). May be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AX/H2A.x and BRCA1 phosphorylations (PubMed:24813610). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates (PubMed:39106863). {ECO:0000250|UniProtKB:P35922, ECO:0000250|UniProtKB:Q80WE1, ECO:0000269|PubMed:11157796, ECO:0000269|PubMed:11532944, ECO:0000269|PubMed:11719189, ECO:0000269|PubMed:12417522, ECO:0000269|PubMed:12594214, ECO:0000269|PubMed:12927206, ECO:0000269|PubMed:12950170, ECO:0000269|PubMed:14703574, ECO:0000269|PubMed:15282548, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15805463, ECO:0000269|PubMed:16631377, ECO:0000269|PubMed:17057366, ECO:0000269|PubMed:17417632, ECO:0000269|PubMed:18579868, ECO:0000269|PubMed:18653529, ECO:0000269|PubMed:18936162, ECO:0000269|PubMed:19097999, ECO:0000269|PubMed:19166269, ECO:0000269|PubMed:20512134, ECO:0000269|PubMed:23235829, ECO:0000269|PubMed:23891804, ECO:0000269|PubMed:24448548, ECO:0000269|PubMed:24813610, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:25561520, ECO:0000269|PubMed:25692235, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:31753916, ECO:0000269|PubMed:39106863, ECO:0000269|PubMed:7688265, ECO:0000269|PubMed:7692601, ECO:0000269|PubMed:7781595, ECO:0000269|PubMed:8156595}.; FUNCTION: [Isoform 10]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: [Isoform 6]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: (Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components. {ECO:0000269|PubMed:24514761}. |
| Q06945 | SOX4 | S81 | ochoa | Transcription factor SOX-4 | Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). {ECO:0000250|UniProtKB:Q06831, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:30661772}. |
| Q07343 | PDE4B | S601 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978}. |
| Q08499 | PDE4D | S657 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q08945 | SSRP1 | S578 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q13017 | ARHGAP5 | S1142 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13427 | PPIG | S695 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q14562 | DHX8 | S385 | ochoa | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. |
| Q14680 | MELK | S407 | psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q15021 | NCAPD2 | S585 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15723 | ELF2 | S304 | ochoa | ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor) | Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.; FUNCTION: Isoform 2 may function in repression of RUNX1-mediated transactivation. |
| Q16600 | ZNF239 | S191 | ochoa | Zinc finger protein 239 (Zinc finger protein HOK-2) (Zinc finger protein MOK-2) | May be involved in transcriptional regulation. |
| Q3KR37 | GRAMD1B | S540 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q3SY56 | SP6 | S298 | ochoa | Transcription factor Sp6 (Krueppel-like factor 14) | Promotes cell proliferation (By similarity). Plays a role in tooth germ growth (By similarity). Plays a role in the control of enamel mineralization. Binds the AMBN promoter (PubMed:32167558). {ECO:0000250|UniProtKB:Q9ESX2, ECO:0000269|PubMed:32167558}. |
| Q5T0W9 | FAM83B | S686 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5VTT5 | MYOM3 | S553 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q66K14 | TBC1D9B | S995 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q6P158 | DHX57 | S77 | ochoa | Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) | Probable ATP-binding RNA helicase. |
| Q6P9A1 | ZNF530 | S130 | ochoa | Zinc finger protein 530 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6Q0C0 | TRAF7 | S317 | ochoa | E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7) | E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:15001576, PubMed:37086853). Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (By similarity). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response (PubMed:37086853). Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B (PubMed:21518757). {ECO:0000250|UniProtKB:Q922B6, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:29961569, ECO:0000269|PubMed:37086853}. |
| Q6U7Q0 | ZNF322 | S83 | psp | Zinc finger protein 322 (Zinc finger protein 322A) (Zinc finger protein 388) (Zinc finger protein 489) | Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZ89, ECO:0000269|PubMed:15555580}. |
| Q7Z4V0 | ZNF438 | S698 | ochoa | Zinc finger protein 438 | Isoform 1 acts as a transcriptional repressor. |
| Q7Z6I6 | ARHGAP30 | S291 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z7L9 | ZSCAN2 | S318 | ochoa | Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) | May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}. |
| Q8IWY8 | ZSCAN29 | S153 | ochoa | Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690) | May be involved in transcriptional regulation. |
| Q8IXZ3 | SP8 | S400 | ochoa | Transcription factor Sp8 (Specificity protein 8) | Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). {ECO:0000250}. |
| Q8IYB5 | SMAP1 | S154 | ochoa | Stromal membrane-associated protein 1 | GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity). {ECO:0000250}. |
| Q8NEM7 | SUPT20H | S296 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8NI27 | THOC2 | S1516 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TAD8 | SNIP1 | S202 | ochoa | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8TED9 | AFAP1L1 | S361 | ochoa | Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) | May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}. |
| Q8TF32 | ZNF431 | S440 | ochoa | Zinc finger protein 431 | Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). {ECO:0000250}. |
| Q8TF47 | ZFP90 | S406 | ochoa | Zinc finger protein 90 homolog (Zfp-90) (Zinc finger protein 756) | Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. {ECO:0000269|PubMed:21284946}.; FUNCTION: [Isoform 2]: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg). {ECO:0000269|PubMed:23543754}. |
| Q8TF47 | ZFP90 | S434 | ochoa | Zinc finger protein 90 homolog (Zfp-90) (Zinc finger protein 756) | Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. {ECO:0000269|PubMed:21284946}.; FUNCTION: [Isoform 2]: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg). {ECO:0000269|PubMed:23543754}. |
| Q8TF68 | ZNF384 | S268 | ochoa | Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein) | Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). {ECO:0000250}. |
| Q8WW38 | ZFPM2 | S904 | ochoa | Zinc finger protein ZFPM2 (Friend of GATA protein 2) (FOG-2) (Friend of GATA 2) (hFOG-2) (Zinc finger protein 89B) (Zinc finger protein multitype 2) | Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:10438528}. |
| Q8WYH8 | ING5 | S123 | ochoa | Inhibitor of growth protein 5 (p28ING5) | Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). {ECO:0000269|PubMed:12750254, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21750715, ECO:0000269|PubMed:24065767}. |
| Q92945 | KHSRP | S191 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q92997 | DVL3 | S211 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96AE4 | FUBP1 | S147 | ochoa | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96H12 | MSANTD3 | S96 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 3 | None |
| Q96K76 | USP47 | S865 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96QT4 | TRPM7 | S1446 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96QZ7 | MAGI1 | S1118 | ochoa | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3) | Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q6RHR9}. |
| Q99490 | AGAP2 | S681 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q99549 | MPHOSPH8 | S319 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9BRH9 | ZNF251 | S333 | ochoa | Zinc finger protein 251 | May be involved in transcriptional regulation. |
| Q9BUN5 | CCDC28B | S46 | ochoa | Coiled-coil domain-containing protein 28B | Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex. {ECO:0000269|PubMed:23015189, ECO:0000269|PubMed:23727834}. |
| Q9GZU2 | PEG3 | S547 | ochoa | Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24) | Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. {ECO:0000250, ECO:0000269|PubMed:11260267}. |
| Q9HCE3 | ZNF532 | S1067 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
| Q9HCH5 | SYTL2 | S301 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NRX4 | PHPT1 | S94 | ochoa | 14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Protein janus-A homolog) | Exhibits phosphohistidine phosphatase activity. {ECO:0000269|PubMed:19836471, ECO:0000269|PubMed:25574816}. |
| Q9NUQ6 | SPATS2L | S493 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NYF8 | BCLAF1 | S690 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYT6 | ZNF226 | S292 | ochoa | Zinc finger protein 226 | May be involved in transcriptional regulation. |
| Q9UBT2 | UBA2 | S229 | ochoa | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}. |
| Q9UHN6 | CEMIP2 | S63 | ochoa | Cell surface hyaluronidase CEMIP2 (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Transmembrane protein 2) | Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 10-5 kDa fragments (PubMed:37527776). Very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate. Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites (By similarity). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). {ECO:0000250|UniProtKB:A3KPQ7, ECO:0000250|UniProtKB:Q5FWI3, ECO:0000269|PubMed:37527776}. |
| Q9UJV9 | DDX41 | S83 | ochoa | Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) | Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:34473945). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses (PubMed:23222971). Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1 (PubMed:25704810). Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity (PubMed:35613581). In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:35613581). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing (PubMed:33650667). Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability (PubMed:36229594). Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis (PubMed:36229594, PubMed:36780110). {ECO:0000250|UniProtKB:Q91VN6, ECO:0000269|PubMed:23222971, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:33650667, ECO:0000269|PubMed:34473945, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:36229594, ECO:0000269|PubMed:36780110}. |
| Q9UKV3 | ACIN1 | S1180 | psp | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULW0 | TPX2 | S121 | ochoa|psp | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9ULW0 | TPX2 | S539 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UN81 | L1RE1 | S50 | ochoa | LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1) | Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269|PubMed:11158327, ECO:0000269|PubMed:21937507, ECO:0000269|PubMed:28806172, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:8945518}. |
| Q9UNF0 | PACSIN2 | S305 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}. |
| Q9Y271 | CYSLTR1 | S316 | ochoa|psp | Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81) | Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. |
| Q9Y388 | RBMX2 | S232 | ochoa | RNA-binding motif protein, X-linked 2 | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9Y520 | PRRC2C | S1500 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| P17174 | GOT1 | S85 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
| O60285 | NUAK1 | S358 | Sugiyama | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
| O60566 | BUB1B | S99 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q9UK13 | ZNF221 | S238 | Sugiyama | Zinc finger protein 221 | May be involved in transcriptional regulation. |
| Q99614 | TTC1 | S187 | Sugiyama | Tetratricopeptide repeat protein 1 (TPR repeat protein 1) | None |
| Q9BR84 | ZNF559 | S197 | Sugiyama | Zinc finger protein 559 | May be involved in transcriptional regulation. |
| Q92478 | CLEC2B | S127 | Sugiyama | C-type lectin domain family 2 member B (Activation-induced C-type lectin) (C-type lectin superfamily member 2) (IFN-alpha-2b-inducing-related protein 1) | Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. {ECO:0000269|PubMed:17057721, ECO:0000269|PubMed:18230726, ECO:0000269|PubMed:23929856}. |
| Q13573 | SNW1 | S83 | Sugiyama | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| P51816 | AFF2 | S622 | Sugiyama | AF4/FMR2 family member 2 (Protein FMR-2) (FMR2P) (Protein Ox19) | RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. {ECO:0000269|PubMed:19136466}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.000116 | 3.935 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.000265 | 3.577 |
| R-HSA-72172 | mRNA Splicing | 0.000370 | 3.432 |
| R-HSA-74160 | Gene expression (Transcription) | 0.000487 | 3.312 |
| R-HSA-212436 | Generic Transcription Pathway | 0.000877 | 3.057 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.001602 | 2.795 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.001289 | 2.890 |
| R-HSA-391906 | Leukotriene receptors | 0.002277 | 2.643 |
| R-HSA-180024 | DARPP-32 events | 0.002617 | 2.582 |
| R-HSA-9664535 | LTC4-CYSLTR mediated IL4 production | 0.004655 | 2.332 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.022839 | 1.641 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.037776 | 1.423 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.059759 | 1.224 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.059759 | 1.224 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.088296 | 1.054 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.017452 | 1.758 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.095295 | 1.021 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.020040 | 1.698 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.109133 | 0.962 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.027154 | 1.566 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.027154 | 1.566 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.028682 | 1.542 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.028682 | 1.542 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.142817 | 0.845 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.149401 | 0.826 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.049486 | 1.306 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.051408 | 1.289 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.051408 | 1.289 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.175238 | 0.756 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.078622 | 1.104 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.206442 | 0.685 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.080870 | 1.092 |
| R-HSA-72649 | Translation initiation complex formation | 0.083138 | 1.080 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.036631 | 1.436 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.036631 | 1.436 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.087732 | 1.057 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.242344 | 0.616 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.111750 | 0.952 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.248169 | 0.605 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.248169 | 0.605 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.259686 | 0.586 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.259686 | 0.586 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.265379 | 0.576 |
| R-HSA-390522 | Striated Muscle Contraction | 0.265379 | 0.576 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.265379 | 0.576 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.265379 | 0.576 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.129458 | 0.888 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.129458 | 0.888 |
| R-HSA-380287 | Centrosome maturation | 0.134633 | 0.871 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.276634 | 0.558 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.153089 | 0.815 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.298635 | 0.525 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.304030 | 0.517 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.166558 | 0.778 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.196838 | 0.706 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.236223 | 0.627 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.271028 | 0.567 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.054997 | 1.260 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.248169 | 0.605 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.216446 | 0.665 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.052487 | 1.280 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.224599 | 0.649 |
| R-HSA-3928664 | Ephrin signaling | 0.162418 | 0.789 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.271028 | 0.567 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.115973 | 0.936 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.298635 | 0.525 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.052487 | 1.280 |
| R-HSA-9664420 | Killing mechanisms | 0.142817 | 0.845 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.142817 | 0.845 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.149401 | 0.826 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.072001 | 1.143 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.230559 | 0.637 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.080870 | 1.092 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.218593 | 0.660 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.158451 | 0.800 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.304030 | 0.517 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.224599 | 0.649 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.097139 | 1.013 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.097139 | 1.013 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.097139 | 1.013 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.097139 | 1.013 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.124333 | 0.905 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.088296 | 1.054 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.264629 | 0.577 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.085425 | 1.068 |
| R-HSA-167169 | HIV Transcription Elongation | 0.051408 | 1.289 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.264629 | 0.577 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.109133 | 0.962 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.136183 | 0.866 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.187863 | 0.726 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.200296 | 0.698 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.206442 | 0.685 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.224599 | 0.649 |
| R-HSA-8949613 | Cristae formation | 0.224599 | 0.649 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.282198 | 0.549 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.287719 | 0.541 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.319971 | 0.495 |
| R-HSA-68877 | Mitotic Prometaphase | 0.024614 | 1.609 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.132040 | 0.879 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.087732 | 1.057 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.242344 | 0.616 |
| R-HSA-4641258 | Degradation of DVL | 0.287719 | 0.541 |
| R-HSA-167172 | Transcription of the HIV genome | 0.116742 | 0.933 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.158451 | 0.800 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.265379 | 0.576 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.206442 | 0.685 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.227731 | 0.643 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 0.088296 | 1.054 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.109133 | 0.962 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.065574 | 1.183 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.092400 | 1.034 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.271028 | 0.567 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.147764 | 0.830 |
| R-HSA-9710421 | Defective pyroptosis | 0.325204 | 0.488 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.236223 | 0.627 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.097139 | 1.013 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.137237 | 0.863 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.086944 | 1.061 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.042073 | 1.376 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.066975 | 1.174 |
| R-HSA-5334118 | DNA methylation | 0.236474 | 0.626 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.259686 | 0.586 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.271028 | 0.567 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.126687 | 0.897 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.199626 | 0.700 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.059759 | 1.224 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.122762 | 0.911 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.142817 | 0.845 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.045723 | 1.340 |
| R-HSA-9839394 | TGFBR3 expression | 0.212541 | 0.673 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.304030 | 0.517 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.304030 | 0.517 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.309385 | 0.510 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.166031 | 0.780 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.126346 | 0.898 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.037607 | 1.425 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.124333 | 0.905 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.124333 | 0.905 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.009541 | 2.020 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.088296 | 1.054 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.282198 | 0.549 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.309385 | 0.510 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.052487 | 1.280 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.088296 | 1.054 |
| R-HSA-448706 | Interleukin-1 processing | 0.088296 | 1.054 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.016215 | 1.790 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.115973 | 0.936 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.115973 | 0.936 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.115973 | 0.936 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.136183 | 0.866 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.175238 | 0.756 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.067495 | 1.171 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.293198 | 0.533 |
| R-HSA-3214847 | HATs acetylate histones | 0.208018 | 0.682 |
| R-HSA-162587 | HIV Life Cycle | 0.153134 | 0.815 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.035127 | 1.454 |
| R-HSA-8953854 | Metabolism of RNA | 0.032859 | 1.483 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.136183 | 0.866 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.162418 | 0.789 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.248169 | 0.605 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.142480 | 0.846 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.304030 | 0.517 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.122762 | 0.911 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.149401 | 0.826 |
| R-HSA-1181150 | Signaling by NODAL | 0.175238 | 0.756 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.298635 | 0.525 |
| R-HSA-68886 | M Phase | 0.200384 | 0.698 |
| R-HSA-162906 | HIV Infection | 0.296610 | 0.528 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.168853 | 0.772 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.136183 | 0.866 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.309385 | 0.510 |
| R-HSA-9843745 | Adipogenesis | 0.312875 | 0.505 |
| R-HSA-69275 | G2/M Transition | 0.074655 | 1.127 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.076736 | 1.115 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.095295 | 1.021 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.129498 | 0.888 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.136183 | 0.866 |
| R-HSA-2408550 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | 0.155935 | 0.807 |
| R-HSA-1237112 | Methionine salvage pathway | 0.168853 | 0.772 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.013887 | 1.857 |
| R-HSA-3295583 | TRP channels | 0.218593 | 0.660 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.230559 | 0.637 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.287719 | 0.541 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.298635 | 0.525 |
| R-HSA-5260271 | Diseases of Immune System | 0.304030 | 0.517 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.304030 | 0.517 |
| R-HSA-418555 | G alpha (s) signalling events | 0.181149 | 0.742 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.222083 | 0.653 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.242344 | 0.616 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.180225 | 0.744 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.287375 | 0.542 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.267049 | 0.573 |
| R-HSA-157118 | Signaling by NOTCH | 0.323894 | 0.490 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.167670 | 0.776 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.013887 | 1.857 |
| R-HSA-977347 | Serine metabolism | 0.187863 | 0.726 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.121789 | 0.914 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.253255 | 0.596 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.149401 | 0.826 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.149401 | 0.826 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.181575 | 0.741 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.010044 | 1.998 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.236474 | 0.626 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.250413 | 0.601 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.276634 | 0.558 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.084413 | 1.074 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.049486 | 1.306 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.088296 | 1.054 |
| R-HSA-9658195 | Leishmania infection | 0.202959 | 0.693 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.202959 | 0.693 |
| R-HSA-1640170 | Cell Cycle | 0.110573 | 0.956 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.206442 | 0.685 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.206442 | 0.685 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.259686 | 0.586 |
| R-HSA-381042 | PERK regulates gene expression | 0.276634 | 0.558 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.049486 | 1.306 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.013504 | 1.870 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.224599 | 0.649 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.172003 | 0.764 |
| R-HSA-373753 | Nephrin family interactions | 0.175238 | 0.756 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.212541 | 0.673 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.038539 | 1.414 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.121789 | 0.914 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.259686 | 0.586 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.020965 | 1.679 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.078622 | 1.104 |
| R-HSA-68882 | Mitotic Anaphase | 0.273648 | 0.563 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.120837 | 0.918 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.275728 | 0.560 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.087732 | 1.057 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.133536 | 0.874 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.168853 | 0.772 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.267473 | 0.573 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.173192 | 0.761 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.035127 | 1.454 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.024550 | 1.610 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.042336 | 1.373 |
| R-HSA-111885 | Opioid Signalling | 0.059851 | 1.223 |
| R-HSA-201556 | Signaling by ALK | 0.298635 | 0.525 |
| R-HSA-4839726 | Chromatin organization | 0.154517 | 0.811 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.309385 | 0.510 |
| R-HSA-622312 | Inflammasomes | 0.230559 | 0.637 |
| R-HSA-75153 | Apoptotic execution phase | 0.065574 | 1.183 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.063736 | 1.196 |
| R-HSA-9679506 | SARS-CoV Infections | 0.284304 | 0.546 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.329774 | 0.482 |
| R-HSA-373752 | Netrin-1 signaling | 0.330397 | 0.481 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.335550 | 0.474 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.335550 | 0.474 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.335550 | 0.474 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.335550 | 0.474 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.335550 | 0.474 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.340664 | 0.468 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.340664 | 0.468 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.340664 | 0.468 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.340664 | 0.468 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.345739 | 0.461 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.365653 | 0.437 |
| R-HSA-72187 | mRNA 3'-end processing | 0.370537 | 0.431 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.370537 | 0.431 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.370537 | 0.431 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.375384 | 0.426 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.380194 | 0.420 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.382435 | 0.417 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.384966 | 0.415 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.384966 | 0.415 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.385162 | 0.414 |
| R-HSA-1989781 | PPARA activates gene expression | 0.385162 | 0.414 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.389703 | 0.409 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.389703 | 0.409 |
| R-HSA-5578775 | Ion homeostasis | 0.389703 | 0.409 |
| R-HSA-177929 | Signaling by EGFR | 0.389703 | 0.409 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.390600 | 0.408 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.394403 | 0.404 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.399067 | 0.399 |
| R-HSA-191859 | snRNP Assembly | 0.403696 | 0.394 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.403696 | 0.394 |
| R-HSA-186712 | Regulation of beta-cell development | 0.403696 | 0.394 |
| R-HSA-109581 | Apoptosis | 0.404102 | 0.394 |
| R-HSA-2262752 | Cellular responses to stress | 0.407508 | 0.390 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.408290 | 0.389 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.409464 | 0.388 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.409616 | 0.388 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.412848 | 0.384 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.412848 | 0.384 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.412848 | 0.384 |
| R-HSA-9707616 | Heme signaling | 0.417371 | 0.379 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.417371 | 0.379 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.417371 | 0.379 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.417371 | 0.379 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.421860 | 0.375 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.421860 | 0.375 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.421860 | 0.375 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.421860 | 0.375 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.426315 | 0.370 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.433297 | 0.363 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.435122 | 0.361 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.435914 | 0.361 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.435914 | 0.361 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.435914 | 0.361 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.435914 | 0.361 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.443795 | 0.353 |
| R-HSA-168255 | Influenza Infection | 0.451479 | 0.345 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.452336 | 0.345 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.452336 | 0.345 |
| R-HSA-2559583 | Cellular Senescence | 0.454050 | 0.343 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.456557 | 0.341 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.456557 | 0.341 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.460747 | 0.337 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.460747 | 0.337 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.460747 | 0.337 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.461722 | 0.336 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.469029 | 0.329 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.469029 | 0.329 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.473123 | 0.325 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.473123 | 0.325 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.477186 | 0.321 |
| R-HSA-5617833 | Cilium Assembly | 0.479378 | 0.319 |
| R-HSA-1500931 | Cell-Cell communication | 0.479947 | 0.319 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.481217 | 0.318 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.485218 | 0.314 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.485218 | 0.314 |
| R-HSA-4086400 | PCP/CE pathway | 0.485218 | 0.314 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.489188 | 0.311 |
| R-HSA-9659379 | Sensory processing of sound | 0.489188 | 0.311 |
| R-HSA-9833482 | PKR-mediated signaling | 0.493128 | 0.307 |
| R-HSA-9609690 | HCMV Early Events | 0.494231 | 0.306 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.494231 | 0.306 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.497037 | 0.304 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.500917 | 0.300 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.503985 | 0.298 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.504767 | 0.297 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.516141 | 0.287 |
| R-HSA-5357801 | Programmed Cell Death | 0.518389 | 0.285 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.519874 | 0.284 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.523579 | 0.281 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.523579 | 0.281 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.527256 | 0.278 |
| R-HSA-156902 | Peptide chain elongation | 0.527256 | 0.278 |
| R-HSA-9824446 | Viral Infection Pathways | 0.527275 | 0.278 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.534524 | 0.272 |
| R-HSA-202424 | Downstream TCR signaling | 0.534524 | 0.272 |
| R-HSA-73884 | Base Excision Repair | 0.534524 | 0.272 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.538117 | 0.269 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.538117 | 0.269 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.541682 | 0.266 |
| R-HSA-391251 | Protein folding | 0.545220 | 0.263 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.545220 | 0.263 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.545220 | 0.263 |
| R-HSA-418990 | Adherens junctions interactions | 0.548640 | 0.261 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.552215 | 0.258 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.555672 | 0.255 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.555672 | 0.255 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.559103 | 0.253 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.562507 | 0.250 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.562507 | 0.250 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.565886 | 0.247 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.567952 | 0.246 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.569238 | 0.245 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.569238 | 0.245 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.569238 | 0.245 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.571000 | 0.243 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.572565 | 0.242 |
| R-HSA-70171 | Glycolysis | 0.575867 | 0.240 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.579143 | 0.237 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.579143 | 0.237 |
| R-HSA-162582 | Signal Transduction | 0.579792 | 0.237 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.582394 | 0.235 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.582394 | 0.235 |
| R-HSA-1483255 | PI Metabolism | 0.582394 | 0.235 |
| R-HSA-192823 | Viral mRNA Translation | 0.585620 | 0.232 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.588821 | 0.230 |
| R-HSA-8939211 | ESR-mediated signaling | 0.590437 | 0.229 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.591998 | 0.228 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.591998 | 0.228 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.595150 | 0.225 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.601383 | 0.221 |
| R-HSA-211000 | Gene Silencing by RNA | 0.601383 | 0.221 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.604463 | 0.219 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.604463 | 0.219 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.607520 | 0.216 |
| R-HSA-202403 | TCR signaling | 0.610554 | 0.214 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.610554 | 0.214 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.610554 | 0.214 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.616551 | 0.210 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.616551 | 0.210 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.616551 | 0.210 |
| R-HSA-9609646 | HCMV Infection | 0.617357 | 0.209 |
| R-HSA-421270 | Cell-cell junction organization | 0.619371 | 0.208 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.619515 | 0.208 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.628272 | 0.202 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.628272 | 0.202 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.629321 | 0.201 |
| R-HSA-373760 | L1CAM interactions | 0.633999 | 0.198 |
| R-HSA-70326 | Glucose metabolism | 0.636829 | 0.196 |
| R-HSA-422475 | Axon guidance | 0.637558 | 0.195 |
| R-HSA-5693538 | Homology Directed Repair | 0.639638 | 0.194 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.642425 | 0.192 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.642425 | 0.192 |
| R-HSA-418594 | G alpha (i) signalling events | 0.643238 | 0.192 |
| R-HSA-416476 | G alpha (q) signalling events | 0.644822 | 0.191 |
| R-HSA-68875 | Mitotic Prophase | 0.645191 | 0.190 |
| R-HSA-3371556 | Cellular response to heat stress | 0.647935 | 0.188 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.650659 | 0.187 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.650659 | 0.187 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.661345 | 0.180 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.661345 | 0.180 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.661345 | 0.180 |
| R-HSA-446728 | Cell junction organization | 0.670723 | 0.173 |
| R-HSA-5576891 | Cardiac conduction | 0.679272 | 0.168 |
| R-HSA-9909396 | Circadian clock | 0.681755 | 0.166 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.681755 | 0.166 |
| R-HSA-9675108 | Nervous system development | 0.686349 | 0.163 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.693886 | 0.159 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.698609 | 0.156 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.700944 | 0.154 |
| R-HSA-195721 | Signaling by WNT | 0.705073 | 0.152 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.710103 | 0.149 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.712349 | 0.147 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.714578 | 0.146 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.721162 | 0.142 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.723323 | 0.141 |
| R-HSA-9758941 | Gastrulation | 0.725468 | 0.139 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.727596 | 0.138 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.727596 | 0.138 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.729274 | 0.137 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.731803 | 0.136 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.731803 | 0.136 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.733882 | 0.134 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.735945 | 0.133 |
| R-HSA-73887 | Death Receptor Signaling | 0.735945 | 0.133 |
| R-HSA-388396 | GPCR downstream signalling | 0.737814 | 0.132 |
| R-HSA-9610379 | HCMV Late Events | 0.742040 | 0.130 |
| R-HSA-9711097 | Cellular response to starvation | 0.744041 | 0.128 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.744041 | 0.128 |
| R-HSA-5619102 | SLC transporter disorders | 0.761366 | 0.118 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.768688 | 0.114 |
| R-HSA-72306 | tRNA processing | 0.768688 | 0.114 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.768940 | 0.114 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.770484 | 0.113 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.774033 | 0.111 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.777528 | 0.109 |
| R-HSA-5663205 | Infectious disease | 0.778411 | 0.109 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.779414 | 0.108 |
| R-HSA-611105 | Respiratory electron transport | 0.782670 | 0.106 |
| R-HSA-73894 | DNA Repair | 0.793143 | 0.101 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.798974 | 0.097 |
| R-HSA-983712 | Ion channel transport | 0.800536 | 0.097 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.803625 | 0.095 |
| R-HSA-372790 | Signaling by GPCR | 0.811824 | 0.091 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.819781 | 0.086 |
| R-HSA-913531 | Interferon Signaling | 0.820524 | 0.086 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.821182 | 0.086 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.821182 | 0.086 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.831964 | 0.080 |
| R-HSA-397014 | Muscle contraction | 0.834617 | 0.079 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.834617 | 0.079 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.835905 | 0.078 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.851760 | 0.070 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.855198 | 0.068 |
| R-HSA-72312 | rRNA processing | 0.858556 | 0.066 |
| R-HSA-15869 | Metabolism of nucleotides | 0.862914 | 0.064 |
| R-HSA-72766 | Translation | 0.864143 | 0.063 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.870235 | 0.060 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.874224 | 0.058 |
| R-HSA-5688426 | Deubiquitination | 0.881863 | 0.055 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.904403 | 0.044 |
| R-HSA-1643685 | Disease | 0.904600 | 0.044 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.909514 | 0.041 |
| R-HSA-1483257 | Phospholipid metabolism | 0.913678 | 0.039 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.914354 | 0.039 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.930733 | 0.031 |
| R-HSA-8957322 | Metabolism of steroids | 0.931276 | 0.031 |
| R-HSA-1474244 | Extracellular matrix organization | 0.934959 | 0.029 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.942660 | 0.026 |
| R-HSA-1266738 | Developmental Biology | 0.946532 | 0.024 |
| R-HSA-500792 | GPCR ligand binding | 0.951033 | 0.022 |
| R-HSA-597592 | Post-translational protein modification | 0.953135 | 0.021 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.957176 | 0.019 |
| R-HSA-199991 | Membrane Trafficking | 0.966935 | 0.015 |
| R-HSA-1280218 | Adaptive Immune System | 0.967683 | 0.014 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.968542 | 0.014 |
| R-HSA-392499 | Metabolism of proteins | 0.970842 | 0.013 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.975782 | 0.011 |
| R-HSA-6798695 | Neutrophil degranulation | 0.976164 | 0.010 |
| R-HSA-112316 | Neuronal System | 0.978157 | 0.010 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.988987 | 0.005 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.991832 | 0.004 |
| R-HSA-449147 | Signaling by Interleukins | 0.993761 | 0.003 |
| R-HSA-109582 | Hemostasis | 0.998269 | 0.001 |
| R-HSA-168249 | Innate Immune System | 0.998532 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999521 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999653 | 0.000 |
| R-HSA-168256 | Immune System | 0.999898 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999958 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.859 | 0.308 | 1 | 0.917 |
COT |
0.852 | 0.069 | 2 | 0.883 |
SRPK1 |
0.851 | 0.210 | -3 | 0.692 |
NLK |
0.848 | 0.282 | 1 | 0.920 |
NDR1 |
0.847 | 0.153 | -3 | 0.784 |
NDR2 |
0.847 | 0.092 | -3 | 0.791 |
SRPK2 |
0.847 | 0.183 | -3 | 0.629 |
CDK18 |
0.843 | 0.375 | 1 | 0.811 |
CLK1 |
0.843 | 0.267 | -3 | 0.702 |
HIPK4 |
0.842 | 0.189 | 1 | 0.901 |
RSK2 |
0.841 | 0.114 | -3 | 0.715 |
PIM3 |
0.841 | 0.048 | -3 | 0.781 |
DYRK2 |
0.841 | 0.307 | 1 | 0.879 |
NUAK2 |
0.841 | 0.085 | -3 | 0.794 |
WNK1 |
0.840 | 0.152 | -2 | 0.872 |
CLK4 |
0.840 | 0.241 | -3 | 0.714 |
PRPK |
0.840 | -0.038 | -1 | 0.869 |
KIS |
0.840 | 0.259 | 1 | 0.872 |
CDK7 |
0.840 | 0.305 | 1 | 0.868 |
P90RSK |
0.840 | 0.092 | -3 | 0.722 |
CLK2 |
0.840 | 0.275 | -3 | 0.698 |
CDC7 |
0.839 | -0.022 | 1 | 0.828 |
CAMK1B |
0.839 | 0.053 | -3 | 0.811 |
AURC |
0.839 | 0.176 | -2 | 0.707 |
RSK3 |
0.839 | 0.098 | -3 | 0.725 |
CDKL1 |
0.839 | 0.084 | -3 | 0.750 |
DSTYK |
0.838 | 0.052 | 2 | 0.884 |
CDK14 |
0.838 | 0.398 | 1 | 0.836 |
CDK8 |
0.838 | 0.272 | 1 | 0.860 |
PRKD2 |
0.838 | 0.078 | -3 | 0.725 |
PIM1 |
0.838 | 0.118 | -3 | 0.727 |
RIPK3 |
0.838 | 0.135 | 3 | 0.828 |
P70S6KB |
0.838 | 0.120 | -3 | 0.751 |
RAF1 |
0.837 | -0.011 | 1 | 0.793 |
CDK16 |
0.837 | 0.398 | 1 | 0.790 |
PKN3 |
0.837 | 0.031 | -3 | 0.795 |
HIPK1 |
0.837 | 0.340 | 1 | 0.881 |
SRPK3 |
0.837 | 0.150 | -3 | 0.679 |
MST4 |
0.837 | 0.116 | 2 | 0.826 |
CDK17 |
0.836 | 0.355 | 1 | 0.778 |
GCN2 |
0.836 | -0.105 | 2 | 0.821 |
PDHK4 |
0.836 | -0.086 | 1 | 0.828 |
ICK |
0.836 | 0.164 | -3 | 0.783 |
CDKL5 |
0.836 | 0.090 | -3 | 0.737 |
MTOR |
0.836 | -0.009 | 1 | 0.805 |
CDK19 |
0.836 | 0.280 | 1 | 0.832 |
ERK5 |
0.836 | 0.126 | 1 | 0.843 |
CAMK2G |
0.836 | 0.024 | 2 | 0.885 |
LATS2 |
0.835 | 0.057 | -5 | 0.657 |
CAMLCK |
0.835 | 0.105 | -2 | 0.880 |
PKACG |
0.835 | 0.114 | -2 | 0.799 |
ULK2 |
0.835 | -0.061 | 2 | 0.794 |
MOS |
0.835 | -0.008 | 1 | 0.863 |
NIK |
0.834 | 0.101 | -3 | 0.834 |
SKMLCK |
0.834 | 0.110 | -2 | 0.881 |
PRKD1 |
0.834 | 0.018 | -3 | 0.764 |
TGFBR2 |
0.834 | 0.040 | -2 | 0.837 |
PKN2 |
0.834 | 0.064 | -3 | 0.787 |
PKCD |
0.834 | 0.090 | 2 | 0.785 |
HIPK2 |
0.834 | 0.319 | 1 | 0.826 |
AMPKA1 |
0.833 | 0.065 | -3 | 0.801 |
CDK5 |
0.833 | 0.294 | 1 | 0.873 |
MARK4 |
0.833 | 0.028 | 4 | 0.808 |
TBK1 |
0.833 | -0.070 | 1 | 0.688 |
BMPR2 |
0.832 | -0.080 | -2 | 0.886 |
WNK3 |
0.832 | 0.012 | 1 | 0.768 |
NEK6 |
0.832 | 0.001 | -2 | 0.861 |
DAPK2 |
0.831 | 0.082 | -3 | 0.820 |
HIPK3 |
0.831 | 0.310 | 1 | 0.871 |
DYRK1B |
0.831 | 0.326 | 1 | 0.850 |
DYRK4 |
0.831 | 0.322 | 1 | 0.838 |
AURB |
0.831 | 0.151 | -2 | 0.708 |
NEK7 |
0.831 | -0.030 | -3 | 0.837 |
CDK13 |
0.831 | 0.277 | 1 | 0.848 |
CDK10 |
0.830 | 0.358 | 1 | 0.829 |
RSK4 |
0.830 | 0.128 | -3 | 0.695 |
DYRK3 |
0.830 | 0.286 | 1 | 0.876 |
MNK2 |
0.830 | 0.113 | -2 | 0.835 |
TSSK2 |
0.830 | 0.037 | -5 | 0.700 |
HUNK |
0.829 | -0.020 | 2 | 0.794 |
PKACB |
0.829 | 0.139 | -2 | 0.732 |
DYRK1A |
0.829 | 0.254 | 1 | 0.900 |
ATR |
0.829 | -0.046 | 1 | 0.798 |
PAK1 |
0.829 | 0.100 | -2 | 0.816 |
PAK3 |
0.829 | 0.092 | -2 | 0.821 |
JNK2 |
0.828 | 0.326 | 1 | 0.830 |
TSSK1 |
0.828 | 0.058 | -3 | 0.810 |
AMPKA2 |
0.828 | 0.049 | -3 | 0.772 |
MNK1 |
0.828 | 0.137 | -2 | 0.853 |
MSK2 |
0.827 | 0.046 | -3 | 0.699 |
PRKD3 |
0.827 | 0.060 | -3 | 0.708 |
NUAK1 |
0.827 | 0.044 | -3 | 0.763 |
CDK9 |
0.827 | 0.280 | 1 | 0.848 |
PDHK1 |
0.827 | -0.161 | 1 | 0.803 |
CAMK2D |
0.827 | -0.001 | -3 | 0.809 |
PIM2 |
0.827 | 0.150 | -3 | 0.704 |
IKKB |
0.827 | -0.162 | -2 | 0.752 |
MELK |
0.827 | 0.065 | -3 | 0.761 |
CDK12 |
0.827 | 0.291 | 1 | 0.832 |
CDK1 |
0.827 | 0.276 | 1 | 0.840 |
IKKE |
0.826 | -0.122 | 1 | 0.686 |
PKCG |
0.826 | 0.101 | 2 | 0.719 |
ULK1 |
0.826 | -0.077 | -3 | 0.801 |
IRE1 |
0.826 | 0.043 | 1 | 0.743 |
NIM1 |
0.826 | 0.019 | 3 | 0.784 |
MAPKAPK3 |
0.826 | -0.032 | -3 | 0.738 |
IRE2 |
0.826 | 0.075 | 2 | 0.753 |
JNK3 |
0.825 | 0.293 | 1 | 0.856 |
CAMK4 |
0.825 | 0.004 | -3 | 0.786 |
P38A |
0.825 | 0.285 | 1 | 0.863 |
QIK |
0.825 | 0.036 | -3 | 0.812 |
P38G |
0.824 | 0.313 | 1 | 0.774 |
PRKX |
0.824 | 0.144 | -3 | 0.643 |
PKG2 |
0.824 | 0.118 | -2 | 0.733 |
MLK1 |
0.824 | -0.080 | 2 | 0.796 |
ERK2 |
0.824 | 0.296 | 1 | 0.851 |
RIPK1 |
0.823 | -0.022 | 1 | 0.755 |
MYLK4 |
0.823 | 0.087 | -2 | 0.817 |
ERK1 |
0.823 | 0.293 | 1 | 0.817 |
NEK9 |
0.823 | -0.049 | 2 | 0.823 |
SGK3 |
0.823 | 0.122 | -3 | 0.720 |
PAK6 |
0.823 | 0.104 | -2 | 0.744 |
PKCB |
0.823 | 0.065 | 2 | 0.718 |
PKCA |
0.822 | 0.076 | 2 | 0.710 |
AKT2 |
0.822 | 0.095 | -3 | 0.649 |
CHAK2 |
0.822 | -0.047 | -1 | 0.879 |
MSK1 |
0.822 | 0.073 | -3 | 0.703 |
QSK |
0.822 | 0.022 | 4 | 0.786 |
BRSK1 |
0.822 | 0.009 | -3 | 0.763 |
NEK2 |
0.821 | 0.081 | 2 | 0.787 |
CAMK2B |
0.821 | 0.025 | 2 | 0.882 |
PHKG1 |
0.820 | 0.025 | -3 | 0.781 |
PKCH |
0.820 | 0.062 | 2 | 0.710 |
CAMK2A |
0.820 | 0.034 | 2 | 0.879 |
PAK2 |
0.819 | 0.065 | -2 | 0.807 |
CDK2 |
0.819 | 0.186 | 1 | 0.873 |
ATM |
0.819 | -0.004 | 1 | 0.738 |
SIK |
0.819 | 0.018 | -3 | 0.733 |
BCKDK |
0.819 | -0.131 | -1 | 0.792 |
PKR |
0.818 | 0.069 | 1 | 0.798 |
MASTL |
0.818 | -0.174 | -2 | 0.828 |
LATS1 |
0.818 | 0.040 | -3 | 0.796 |
ALK4 |
0.818 | 0.053 | -2 | 0.873 |
CDK3 |
0.818 | 0.258 | 1 | 0.791 |
P38B |
0.818 | 0.275 | 1 | 0.822 |
ANKRD3 |
0.818 | -0.038 | 1 | 0.797 |
BRSK2 |
0.818 | -0.010 | -3 | 0.788 |
MARK3 |
0.817 | 0.027 | 4 | 0.751 |
MAPKAPK2 |
0.817 | -0.037 | -3 | 0.686 |
FAM20C |
0.817 | 0.084 | 2 | 0.715 |
PKCZ |
0.817 | 0.040 | 2 | 0.763 |
GRK5 |
0.817 | -0.190 | -3 | 0.792 |
CHK1 |
0.817 | -0.003 | -3 | 0.790 |
BMPR1B |
0.816 | 0.066 | 1 | 0.760 |
AURA |
0.815 | 0.062 | -2 | 0.672 |
SNRK |
0.815 | -0.048 | 2 | 0.686 |
CAMK1G |
0.815 | 0.040 | -3 | 0.731 |
CDK4 |
0.815 | 0.315 | 1 | 0.824 |
MLK2 |
0.815 | -0.109 | 2 | 0.807 |
MARK2 |
0.815 | 0.009 | 4 | 0.711 |
DNAPK |
0.815 | 0.047 | 1 | 0.679 |
MLK3 |
0.815 | -0.034 | 2 | 0.726 |
TGFBR1 |
0.815 | 0.047 | -2 | 0.848 |
PLK1 |
0.814 | -0.043 | -2 | 0.835 |
P70S6K |
0.814 | 0.068 | -3 | 0.675 |
DCAMKL1 |
0.814 | 0.062 | -3 | 0.740 |
GRK1 |
0.814 | -0.055 | -2 | 0.779 |
MARK1 |
0.813 | 0.006 | 4 | 0.775 |
IKKA |
0.813 | -0.135 | -2 | 0.734 |
PRP4 |
0.813 | 0.146 | -3 | 0.678 |
WNK4 |
0.813 | 0.069 | -2 | 0.866 |
PKCT |
0.813 | 0.080 | 2 | 0.722 |
PKACA |
0.813 | 0.101 | -2 | 0.681 |
SSTK |
0.813 | 0.063 | 4 | 0.779 |
GRK6 |
0.813 | -0.135 | 1 | 0.797 |
AKT1 |
0.813 | 0.096 | -3 | 0.667 |
DLK |
0.812 | -0.202 | 1 | 0.788 |
SMMLCK |
0.812 | 0.096 | -3 | 0.778 |
ALK2 |
0.811 | 0.055 | -2 | 0.851 |
CDK6 |
0.811 | 0.298 | 1 | 0.820 |
TTBK2 |
0.810 | -0.137 | 2 | 0.707 |
PKCI |
0.810 | 0.099 | 2 | 0.728 |
MLK4 |
0.810 | -0.041 | 2 | 0.717 |
PINK1 |
0.810 | 0.025 | 1 | 0.855 |
CAMK1D |
0.809 | 0.050 | -3 | 0.683 |
CHAK1 |
0.809 | -0.065 | 2 | 0.734 |
PHKG2 |
0.809 | 0.048 | -3 | 0.756 |
MOK |
0.809 | 0.248 | 1 | 0.848 |
VRK2 |
0.809 | -0.097 | 1 | 0.849 |
IRAK4 |
0.809 | 0.069 | 1 | 0.735 |
MEK1 |
0.809 | -0.124 | 2 | 0.845 |
PLK3 |
0.808 | -0.048 | 2 | 0.817 |
DRAK1 |
0.808 | -0.027 | 1 | 0.713 |
P38D |
0.808 | 0.284 | 1 | 0.783 |
ACVR2A |
0.807 | -0.009 | -2 | 0.815 |
ACVR2B |
0.807 | -0.005 | -2 | 0.832 |
BRAF |
0.807 | 0.009 | -4 | 0.810 |
DAPK3 |
0.807 | 0.124 | -3 | 0.756 |
MAPKAPK5 |
0.806 | -0.078 | -3 | 0.695 |
GRK4 |
0.806 | -0.189 | -2 | 0.824 |
MAK |
0.806 | 0.227 | -2 | 0.724 |
HRI |
0.806 | -0.074 | -2 | 0.862 |
DCAMKL2 |
0.805 | 0.030 | -3 | 0.768 |
NEK5 |
0.805 | 0.050 | 1 | 0.767 |
PKCE |
0.805 | 0.091 | 2 | 0.696 |
MEKK1 |
0.805 | -0.035 | 1 | 0.760 |
PERK |
0.804 | -0.069 | -2 | 0.851 |
SGK1 |
0.804 | 0.109 | -3 | 0.571 |
PAK5 |
0.803 | 0.075 | -2 | 0.686 |
MRCKB |
0.803 | 0.142 | -3 | 0.705 |
AKT3 |
0.802 | 0.093 | -3 | 0.584 |
MST3 |
0.802 | 0.052 | 2 | 0.793 |
YSK4 |
0.802 | -0.162 | 1 | 0.723 |
BMPR1A |
0.801 | 0.053 | 1 | 0.746 |
MEK5 |
0.801 | -0.100 | 2 | 0.821 |
SMG1 |
0.801 | -0.095 | 1 | 0.747 |
PKN1 |
0.801 | 0.036 | -3 | 0.691 |
MRCKA |
0.801 | 0.146 | -3 | 0.724 |
PLK4 |
0.800 | -0.065 | 2 | 0.645 |
ROCK2 |
0.799 | 0.159 | -3 | 0.741 |
DAPK1 |
0.799 | 0.087 | -3 | 0.740 |
PAK4 |
0.799 | 0.070 | -2 | 0.687 |
TLK2 |
0.799 | -0.131 | 1 | 0.773 |
ZAK |
0.799 | -0.085 | 1 | 0.727 |
IRAK1 |
0.798 | -0.075 | -1 | 0.816 |
TLK1 |
0.797 | -0.083 | -2 | 0.839 |
DMPK1 |
0.797 | 0.191 | -3 | 0.713 |
MEKK3 |
0.797 | -0.118 | 1 | 0.754 |
MEKK2 |
0.797 | -0.072 | 2 | 0.807 |
JNK1 |
0.797 | 0.231 | 1 | 0.823 |
ERK7 |
0.797 | 0.085 | 2 | 0.519 |
LKB1 |
0.796 | 0.052 | -3 | 0.839 |
GRK2 |
0.795 | -0.092 | -2 | 0.713 |
PASK |
0.795 | -0.027 | -3 | 0.803 |
CK1E |
0.795 | -0.046 | -3 | 0.473 |
TAO3 |
0.794 | -0.047 | 1 | 0.760 |
GRK7 |
0.794 | -0.086 | 1 | 0.741 |
TAO2 |
0.794 | -0.007 | 2 | 0.833 |
CAMK1A |
0.793 | 0.023 | -3 | 0.625 |
NEK4 |
0.793 | 0.026 | 1 | 0.733 |
MPSK1 |
0.793 | -0.014 | 1 | 0.743 |
CHK2 |
0.793 | 0.018 | -3 | 0.600 |
NEK8 |
0.793 | -0.075 | 2 | 0.798 |
GSK3A |
0.792 | 0.042 | 4 | 0.426 |
SBK |
0.792 | 0.049 | -3 | 0.540 |
ROCK1 |
0.791 | 0.149 | -3 | 0.712 |
CAMKK1 |
0.791 | -0.083 | -2 | 0.755 |
HASPIN |
0.791 | 0.224 | -1 | 0.888 |
GSK3B |
0.790 | -0.020 | 4 | 0.417 |
LOK |
0.790 | 0.052 | -2 | 0.800 |
NEK11 |
0.790 | -0.089 | 1 | 0.750 |
MEKK6 |
0.789 | 0.004 | 1 | 0.742 |
TNIK |
0.789 | 0.031 | 3 | 0.808 |
NEK1 |
0.789 | 0.045 | 1 | 0.736 |
CRIK |
0.788 | 0.118 | -3 | 0.661 |
PKG1 |
0.788 | 0.065 | -2 | 0.661 |
LRRK2 |
0.788 | -0.005 | 2 | 0.832 |
CAMKK2 |
0.787 | -0.074 | -2 | 0.754 |
PDK1 |
0.787 | -0.064 | 1 | 0.761 |
STK33 |
0.787 | -0.023 | 2 | 0.631 |
HGK |
0.786 | -0.018 | 3 | 0.806 |
GAK |
0.786 | -0.048 | 1 | 0.773 |
TTBK1 |
0.786 | -0.133 | 2 | 0.631 |
GCK |
0.786 | -0.030 | 1 | 0.760 |
BUB1 |
0.785 | 0.057 | -5 | 0.662 |
HPK1 |
0.784 | 0.002 | 1 | 0.742 |
EEF2K |
0.783 | -0.050 | 3 | 0.767 |
PBK |
0.783 | 0.032 | 1 | 0.690 |
MINK |
0.783 | -0.048 | 1 | 0.737 |
NEK3 |
0.783 | 0.044 | 1 | 0.708 |
CK1D |
0.782 | -0.060 | -3 | 0.427 |
KHS1 |
0.782 | 0.022 | 1 | 0.736 |
CK1G1 |
0.782 | -0.089 | -3 | 0.472 |
KHS2 |
0.782 | 0.047 | 1 | 0.751 |
MAP3K15 |
0.781 | -0.073 | 1 | 0.715 |
CK2A2 |
0.780 | -0.023 | 1 | 0.712 |
CK1A2 |
0.780 | -0.060 | -3 | 0.425 |
YSK1 |
0.779 | -0.013 | 2 | 0.785 |
SLK |
0.779 | -0.047 | -2 | 0.734 |
RIPK2 |
0.778 | -0.159 | 1 | 0.688 |
GRK3 |
0.777 | -0.108 | -2 | 0.671 |
TAK1 |
0.777 | -0.142 | 1 | 0.786 |
VRK1 |
0.777 | -0.156 | 2 | 0.829 |
MEK2 |
0.776 | -0.119 | 2 | 0.811 |
MST2 |
0.776 | -0.147 | 1 | 0.759 |
PLK2 |
0.775 | -0.064 | -3 | 0.768 |
TTK |
0.774 | 0.063 | -2 | 0.839 |
MST1 |
0.773 | -0.104 | 1 | 0.739 |
PDHK3_TYR |
0.773 | 0.122 | 4 | 0.854 |
CK2A1 |
0.771 | -0.028 | 1 | 0.691 |
TESK1_TYR |
0.769 | 0.091 | 3 | 0.823 |
MYO3B |
0.768 | 0.001 | 2 | 0.793 |
LIMK2_TYR |
0.767 | 0.142 | -3 | 0.838 |
PKMYT1_TYR |
0.766 | 0.075 | 3 | 0.813 |
BIKE |
0.764 | -0.025 | 1 | 0.639 |
TAO1 |
0.764 | -0.038 | 1 | 0.687 |
PDHK4_TYR |
0.763 | 0.013 | 2 | 0.895 |
MYO3A |
0.761 | -0.045 | 1 | 0.744 |
MAP2K4_TYR |
0.761 | -0.089 | -1 | 0.876 |
ASK1 |
0.761 | -0.081 | 1 | 0.704 |
MAP2K7_TYR |
0.761 | -0.086 | 2 | 0.864 |
LIMK1_TYR |
0.760 | 0.033 | 2 | 0.847 |
PINK1_TYR |
0.760 | -0.045 | 1 | 0.810 |
MAP2K6_TYR |
0.759 | -0.068 | -1 | 0.879 |
OSR1 |
0.759 | -0.122 | 2 | 0.797 |
EPHA6 |
0.759 | 0.066 | -1 | 0.827 |
RET |
0.757 | -0.015 | 1 | 0.760 |
ALPHAK3 |
0.757 | -0.075 | -1 | 0.793 |
BMPR2_TYR |
0.755 | -0.065 | -1 | 0.852 |
MST1R |
0.755 | 0.011 | 3 | 0.824 |
PDHK1_TYR |
0.755 | -0.116 | -1 | 0.878 |
ROS1 |
0.754 | -0.016 | 3 | 0.793 |
TNK1 |
0.752 | 0.104 | 3 | 0.785 |
DDR1 |
0.752 | 0.001 | 4 | 0.771 |
YANK3 |
0.752 | -0.070 | 2 | 0.432 |
TYRO3 |
0.752 | -0.061 | 3 | 0.794 |
EPHB4 |
0.751 | -0.014 | -1 | 0.811 |
TYK2 |
0.751 | -0.101 | 1 | 0.752 |
TNK2 |
0.751 | 0.088 | 3 | 0.779 |
INSRR |
0.750 | 0.017 | 3 | 0.779 |
KDR |
0.750 | 0.087 | 3 | 0.824 |
FGFR2 |
0.750 | 0.045 | 3 | 0.812 |
CSF1R |
0.750 | -0.016 | 3 | 0.819 |
ABL2 |
0.749 | -0.011 | -1 | 0.811 |
JAK3 |
0.748 | -0.017 | 1 | 0.743 |
AAK1 |
0.748 | -0.002 | 1 | 0.539 |
JAK2 |
0.747 | -0.092 | 1 | 0.754 |
YES1 |
0.747 | -0.031 | -1 | 0.819 |
TEK |
0.747 | 0.012 | 3 | 0.746 |
TXK |
0.746 | 0.002 | 1 | 0.785 |
ABL1 |
0.746 | -0.030 | -1 | 0.803 |
TNNI3K_TYR |
0.745 | 0.012 | 1 | 0.772 |
DDR2 |
0.745 | 0.100 | 3 | 0.764 |
PDGFRB |
0.744 | -0.064 | 3 | 0.813 |
BLK |
0.744 | 0.062 | -1 | 0.796 |
NEK10_TYR |
0.744 | -0.055 | 1 | 0.650 |
AXL |
0.743 | 0.007 | 3 | 0.815 |
SRMS |
0.742 | -0.056 | 1 | 0.792 |
FGFR1 |
0.742 | -0.028 | 3 | 0.788 |
MERTK |
0.742 | -0.008 | 3 | 0.815 |
STLK3 |
0.742 | -0.188 | 1 | 0.702 |
FER |
0.742 | -0.139 | 1 | 0.813 |
EPHA4 |
0.741 | -0.037 | 2 | 0.803 |
HCK |
0.741 | -0.073 | -1 | 0.792 |
JAK1 |
0.741 | -0.002 | 1 | 0.695 |
FLT3 |
0.740 | -0.085 | 3 | 0.796 |
FGR |
0.740 | -0.143 | 1 | 0.771 |
ITK |
0.740 | -0.097 | -1 | 0.789 |
KIT |
0.740 | -0.065 | 3 | 0.803 |
LCK |
0.740 | -0.030 | -1 | 0.790 |
EPHA1 |
0.739 | 0.026 | 3 | 0.807 |
EPHB1 |
0.739 | -0.082 | 1 | 0.784 |
WEE1_TYR |
0.739 | -0.038 | -1 | 0.778 |
CK1A |
0.738 | -0.110 | -3 | 0.338 |
TEC |
0.738 | -0.039 | -1 | 0.729 |
EPHB3 |
0.738 | -0.069 | -1 | 0.789 |
EPHB2 |
0.737 | -0.058 | -1 | 0.787 |
FGFR3 |
0.737 | -0.004 | 3 | 0.801 |
LTK |
0.736 | -0.069 | 3 | 0.757 |
EPHA7 |
0.736 | -0.008 | 2 | 0.803 |
PDGFRA |
0.735 | -0.132 | 3 | 0.808 |
ALK |
0.735 | -0.095 | 3 | 0.732 |
BMX |
0.735 | -0.055 | -1 | 0.714 |
MET |
0.735 | -0.057 | 3 | 0.805 |
FLT4 |
0.733 | -0.054 | 3 | 0.796 |
FLT1 |
0.731 | -0.074 | -1 | 0.817 |
BTK |
0.731 | -0.172 | -1 | 0.757 |
INSR |
0.730 | -0.084 | 3 | 0.760 |
NTRK1 |
0.730 | -0.127 | -1 | 0.814 |
NTRK2 |
0.729 | -0.097 | 3 | 0.794 |
ERBB2 |
0.729 | -0.112 | 1 | 0.717 |
EPHA3 |
0.728 | -0.092 | 2 | 0.779 |
PTK2B |
0.728 | -0.045 | -1 | 0.766 |
MATK |
0.727 | -0.066 | -1 | 0.766 |
EPHA5 |
0.727 | -0.030 | 2 | 0.800 |
FRK |
0.726 | -0.106 | -1 | 0.803 |
FYN |
0.725 | -0.074 | -1 | 0.764 |
LYN |
0.724 | -0.103 | 3 | 0.738 |
PTK6 |
0.723 | -0.231 | -1 | 0.745 |
NTRK3 |
0.722 | -0.105 | -1 | 0.767 |
EPHA8 |
0.722 | -0.062 | -1 | 0.771 |
CK1G3 |
0.721 | -0.106 | -3 | 0.298 |
YANK2 |
0.719 | -0.089 | 2 | 0.457 |
EGFR |
0.716 | -0.097 | 1 | 0.631 |
FGFR4 |
0.716 | -0.084 | -1 | 0.773 |
SRC |
0.715 | -0.130 | -1 | 0.768 |
EPHA2 |
0.714 | -0.057 | -1 | 0.737 |
PTK2 |
0.714 | -0.043 | -1 | 0.736 |
CSK |
0.714 | -0.164 | 2 | 0.798 |
MUSK |
0.711 | -0.130 | 1 | 0.610 |
IGF1R |
0.711 | -0.119 | 3 | 0.696 |
ERBB4 |
0.706 | -0.068 | 1 | 0.652 |
SYK |
0.705 | -0.106 | -1 | 0.741 |
FES |
0.699 | -0.123 | -1 | 0.699 |
CK1G2 |
0.697 | -0.117 | -3 | 0.396 |
ZAP70 |
0.686 | -0.100 | -1 | 0.686 |