Motif 711 (n=143)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1A5D9 | BICDL2 | S351 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
| H0Y626 | None | S38 | ochoa | RING-type E3 ubiquitin transferase (EC 2.3.2.27) | None |
| O14828 | SCAMP3 | S87 | ochoa | Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O15027 | SEC16A | S1601 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15055 | PER2 | S700 | psp | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O15151 | MDM4 | S161 | ochoa | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}. |
| O15155 | BET1 | S50 | ochoa|psp | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | Required for vesicular transport from the ER to the Golgi complex (PubMed:34779586). Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). {ECO:0000250|UniProtKB:Q62896, ECO:0000269|PubMed:34779586}. |
| O15265 | ATXN7 | S115 | ochoa | Ataxin-7 (Spinocerebellar ataxia type 7 protein) | Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}. |
| O15516 | CLOCK | S408 | ochoa | Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}. |
| O43157 | PLXNB1 | S1534 | ochoa | Plexin-B1 (Semaphorin receptor SEP) | Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496). {ECO:0000250|UniProtKB:Q8CJH3, ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. |
| O43290 | SART1 | S598 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O43663 | PRC1 | S267 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O60237 | PPP1R12B | S618 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O60285 | NUAK1 | S603 | ochoa | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
| O60437 | PPL | S949 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O60711 | LPXN | S34 | ochoa | Leupaxin | Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}. |
| O75379 | VAMP4 | S92 | ochoa | Vesicle-associated membrane protein 4 (VAMP-4) | Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. |
| O75528 | TADA3 | S330 | ochoa | Transcriptional adapter 3 (ADA3 homolog) (hADA3) (STAF54) (Transcriptional adapter 3-like) (ADA3-like protein) | Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:11707411, ECO:0000269|PubMed:19103755}. |
| O75864 | PPP1R37 | S667 | ochoa | Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| O95239 | KIF4A | S810 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95361 | TRIM16 | S38 | ochoa | Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}. |
| O95684 | CEP43 | S207 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| O95785 | WIZ | S1352 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P04844 | RPN2 | S516 | ochoa | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2) | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. {ECO:0000250|UniProtKB:F1PCT7, ECO:0000269|PubMed:31831667}. |
| P06576 | ATP5F1B | S106 | ochoa | ATP synthase F(1) complex subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) | Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:25168243, ECO:0000305|PubMed:36239646, ECO:0000305|PubMed:37244256}. |
| P08069 | IGF1R | Y1280 | psp | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P08590 | MYL3 | T159 | ochoa | Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb) | Regulatory light chain of myosin. Does not bind calcium. |
| P08670 | VIM | S205 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P12882 | MYH1 | S1288 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1306 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | T1302 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | T1304 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P14136 | GFAP | S323 | ochoa | Glial fibrillary acidic protein (GFAP) | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| P17028 | ZNF24 | S142 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P17029 | ZKSCAN1 | S289 | ochoa | Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) | May be involved in transcriptional regulation. |
| P18583 | SON | S1670 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P20700 | LMNB1 | S375 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P23246 | SFPQ | S521 | ochoa | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
| P33241 | LSP1 | Y125 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P35579 | MYH9 | S841 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S1756 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P36382 | GJA5 | S120 | ochoa | Gap junction alpha-5 protein (Connexin-40) (Cx40) | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| P38398 | BRCA1 | S403 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40121 | CAPG | S318 | ochoa | Macrophage-capping protein (Actin regulatory protein CAP-G) | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
| P46100 | ATRX | S634 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P52757 | CHN2 | S173 | psp | Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3) | GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. |
| P56524 | HDAC4 | S584 | psp | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P56945 | BCAR1 | S694 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P58004 | SESN2 | S279 | ochoa | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190, PubMed:35114100, PubMed:35831510, PubMed:36528027). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821). {ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:18692468, ECO:0000269|PubMed:19113821, ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:24947615, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190, ECO:0000269|PubMed:26612684, ECO:0000269|PubMed:35114100, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}. |
| P60660 | MYL6 | T115 | ochoa | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | Regulatory light chain of myosin. Does not bind calcium. |
| P78345 | RPP38 | S226 | ochoa | Ribonuclease P protein subunit p38 (RNaseP protein p38) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}. |
| P84098 | RPL19 | S164 | ochoa | Large ribosomal subunit protein eL19 (60S ribosomal protein L19) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q01658 | DR1 | S106 | ochoa | Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}. |
| Q02952 | AKAP12 | S364 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S1755 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q04637 | EIF4G1 | S895 | psp | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q08378 | GOLGA3 | S395 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q12888 | TP53BP1 | S287 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12929 | EPS8 | S57 | psp | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13444 | ADAM15 | S56 | ochoa | Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin) | Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}. |
| Q13555 | CAMK2G | S381 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q14151 | SAFB2 | S246 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14571 | ITPR2 | S2636 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity). {ECO:0000250|UniProtKB:Q9Z329}. |
| Q14789 | GOLGB1 | S491 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14847 | LASP1 | S61 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q14966 | ZNF638 | S1667 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14980 | NUMA1 | S1105 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15027 | ACAP1 | S231 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17398097, ECO:0000269|PubMed:17664335, ECO:0000269|PubMed:22645133}. |
| Q15424 | SAFB | S197 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15424 | SAFB | S247 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15475 | SIX1 | S150 | ochoa | Homeobox protein SIX1 (Sine oculis homeobox homolog 1) | Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (By similarity). Plays an important role in the development of several organs, including kidney, muscle and inner ear (By similarity). Depending on context, functions as a transcriptional repressor or activator (By similarity). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (PubMed:15141091). Mediates nuclear translocation of EYA1 and EYA2 (PubMed:19497856). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (PubMed:15141091, PubMed:19497856, PubMed:23435380, PubMed:27923061). Regulates the expression of numerous genes, including MYC, CCND1 and EZR (By similarity). Acts as an activator of the IGFBP5 promoter, probably coactivated by EYA2 (By similarity). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1 (PubMed:15123840). Promotes brown adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q62231, ECO:0000269|PubMed:15123840, ECO:0000269|PubMed:15141091, ECO:0000269|PubMed:19497856, ECO:0000269|PubMed:23435380, ECO:0000269|PubMed:27923061}. |
| Q16568 | CARTPT | S48 | ochoa | Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39); CART(42-89)] | Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro. {ECO:0000269|PubMed:9590691}. |
| Q16836 | HADH | S73 | ochoa | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity). {ECO:0000250|UniProtKB:Q61425, ECO:0000269|PubMed:10231530, ECO:0000269|PubMed:11489939, ECO:0000269|PubMed:16725361}. |
| Q4V328 | GRIPAP1 | S318 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q53EZ4 | CEP55 | S396 | ochoa | Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) | Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}. |
| Q5VWN6 | TASOR2 | S607 | ochoa | Protein TASOR 2 | None |
| Q63HN8 | RNF213 | S2606 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q69YN4 | VIRMA | S584 | ochoa | Protein virilizer homolog | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| Q6IBW4 | NCAPH2 | S492 | ochoa|psp | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6KC79 | NIPBL | S2684 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6WCQ1 | MPRIP | S671 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZRV2 | FAM83H | S788 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q7L4E1 | MIGA2 | S224 | ochoa | Mitoguardin 2 (Protein FAM73B) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q7Z6J6 | FRMD5 | S462 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
| Q7Z7G8 | VPS13B | S411 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86U86 | PBRM1 | S1405 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86VS8 | HOOK3 | S238 | ochoa | Protein Hook homolog 3 (h-hook3) (hHK3) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}. |
| Q8IWE5 | PLEKHM2 | S532 | ochoa | Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) | Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}. |
| Q8N4C6 | NIN | S174 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N9T8 | KRI1 | S163 | ochoa | Protein KRI1 homolog | None |
| Q8NBJ4 | GOLM1 | S187 | ochoa | Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) | Unknown. Cellular response protein to viral infection. |
| Q8NDI1 | EHBP1 | S578 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NEF9 | SRFBP1 | S145 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8NFC6 | BOD1L1 | S637 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFC6 | BOD1L1 | S1100 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8TB45 | DEPTOR | S168 | psp | DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}. |
| Q8TBA6 | GOLGA5 | S585 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TEH3 | DENND1A | S988 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8WYP5 | AHCTF1 | S1946 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92545 | TMEM131 | S1424 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92729 | PTPRU | S809 | ochoa | Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) | Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12501215, ECO:0000269|PubMed:16574648}. |
| Q96A49 | SYAP1 | S277 | ochoa | Synapse-associated protein 1 (BSD domain-containing signal transducer and Akt interactor protein) (BSTA) | Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}. |
| Q96A65 | EXOC4 | S254 | ochoa | Exocyst complex component 4 (Exocyst complex component Sec8) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}. |
| Q96EV2 | RBM33 | S233 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96FF9 | CDCA5 | S139 | psp | Sororin (Cell division cycle-associated protein 5) (p35) | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
| Q96HC4 | PDLIM5 | S282 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96HY6 | DDRGK1 | S150 | ochoa | DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1) | Component of the UFM1 ribosome E3 ligase (UREL) complex, a multiprotein complex that catalyzes ufmylation of endoplasmic reticulum-docked proteins (PubMed:30626644, PubMed:32160526, PubMed:35753586, PubMed:36121123, PubMed:36543799, PubMed:37595036, PubMed:37795761, PubMed:38383785, PubMed:38383789). The UREL complex plays a key role in ribosome recycling by mediating mono-ufmylation of the RPL26/uL24 subunit of the 60S ribosome following ribosome dissociation: ufmylation weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (PubMed:38383785, PubMed:38383789). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (PubMed:37595036, PubMed:38383785, PubMed:38383789). Within the UREL complex, DDRGK1 tethers the complex to the endoplasmic reticulum membrane to restrict its activity to endoplasmic reticulum-docked ribosomes and acts as an ufmylation 'reader': following RPL26/uL24 ufmylation, DDRGK1 specifically binds to ufmylated RPL26/uL24 via its UFIM motif, resulting in stable association between the 60S ribosome and the UREL complex, followed by dissociation of the 60S ribosome subunit from the endoplasmic reticulum membrane (PubMed:36121123, PubMed:37595036, PubMed:38383785, PubMed:38383789). The UREL complex is also involved in reticulophagy in response to endoplasmic reticulum stress by promoting ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (PubMed:32160526, PubMed:36543799). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (PubMed:28128204, PubMed:32160526). Acts as a regulator of immunity by promoting differentiation of B-cells into plasma cells: acts by promoting expansion of the endoplasmic reticulum and regulating the unfolded protein response (UPR) (By similarity). May also be required for TRIP4 ufmylation (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186). Required for stabilization and ufmylation of ATG9A (By similarity). {ECO:0000250|UniProtKB:Q80WW9, ECO:0000269|PubMed:23675531, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:28263186, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:35753586, ECO:0000269|PubMed:36121123, ECO:0000269|PubMed:36543799, ECO:0000269|PubMed:37595036, ECO:0000269|PubMed:37795761, ECO:0000269|PubMed:38383785, ECO:0000269|PubMed:38383789}. |
| Q96JP2 | MYO15B | S1502 | ochoa | Unconventional myosin-XVB (Myosin XVBP) (Unconventional myosin-15B) | None |
| Q96N46 | TTC14 | S544 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96SN8 | CDK5RAP2 | S366 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99661 | KIF2C | S181 | ochoa | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q99808 | SLC29A1 | S254 | ochoa|psp | Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) | Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}. |
| Q9BVJ6 | UTP14A | S407 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BW71 | HIRIP3 | S219 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BZE4 | GTPBP4 | S470 | ochoa | GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1) | Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539). {ECO:0000269|PubMed:20308539, ECO:0000269|PubMed:32669547}. |
| Q9H000 | MKRN2 | S365 | ochoa | E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity). {ECO:0000250|UniProtKB:Q9ERV1}. |
| Q9H173 | SIL1 | S147 | ochoa | Nucleotide exchange factor SIL1 (BiP-associated protein) (BAP) | Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000269|PubMed:12356756}. |
| Q9H3U1 | UNC45A | S472 | ochoa | Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1) | Acts as a co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). {ECO:0000250, ECO:0000269|PubMed:12119110, ECO:0000269|PubMed:16478993, ECO:0000305}. |
| Q9H583 | HEATR1 | S1492 | ochoa | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:38225354}. |
| Q9H987 | SYNPO2L | S401 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9NPC8 | SIX2 | S150 | ochoa | Homeobox protein SIX2 (Sine oculis homeobox homolog 2) | Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. May also be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration. {ECO:0000250|UniProtKB:Q62232, ECO:0000269|PubMed:22995329}. |
| Q9NYH9 | UTP6 | S204 | ochoa | U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}. |
| Q9P2D1 | CHD7 | S2956 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2E9 | RRBP1 | S1340 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9P2N2 | ARHGAP28 | S180 | ochoa | Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9UBL0 | ARPP21 | S33 | ochoa | cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein) | Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}. |
| Q9UBU7 | DBF4 | S413 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UJX4 | ANAPC5 | S179 | ochoa | Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9UKV3 | ACIN1 | S749 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKX2 | MYH2 | S1290 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1308 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9Y2K5 | R3HDM2 | S37 | ochoa | R3H domain-containing protein 2 | None |
| Q9Y448 | KNSTRN | S237 | ochoa | Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1) | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}. |
| Q04637 | EIF4G1 | S1430 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q02818 | NUCB1 | S193 | Sugiyama | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| P20810 | CAST | Y339 | Sugiyama | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| O60566 | BUB1B | S694 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q12983 | BNIP3 | S35 | GPS6 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}. |
| Q8TDY2 | RB1CC1 | S1323 | PSP | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q9P2B4 | CTTNBP2NL | S240 | Sugiyama | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| P20042 | EIF2S2 | S160 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| O60333 | KIF1B | S654 | Sugiyama | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| Q8N3D4 | EHBP1L1 | S927 | Sugiyama | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.000109 | 3.964 |
| R-HSA-68886 | M Phase | 0.000148 | 3.829 |
| R-HSA-1640170 | Cell Cycle | 0.000076 | 4.118 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.000191 | 3.719 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.000246 | 3.609 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000552 | 3.258 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.001143 | 2.942 |
| R-HSA-68877 | Mitotic Prometaphase | 0.001077 | 2.968 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.001533 | 2.815 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.003746 | 2.426 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.004080 | 2.389 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.004801 | 2.319 |
| R-HSA-373755 | Semaphorin interactions | 0.005043 | 2.297 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.005131 | 2.290 |
| R-HSA-390522 | Striated Muscle Contraction | 0.006922 | 2.160 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.008483 | 2.071 |
| R-HSA-68882 | Mitotic Anaphase | 0.007983 | 2.098 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.008158 | 2.088 |
| R-HSA-9635465 | Suppression of apoptosis | 0.008158 | 2.088 |
| R-HSA-397014 | Muscle contraction | 0.007307 | 2.136 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.006018 | 2.221 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.007903 | 2.102 |
| R-HSA-9830369 | Kidney development | 0.006098 | 2.215 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.009306 | 2.031 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.018946 | 1.722 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.018946 | 1.722 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.018946 | 1.722 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.018946 | 1.722 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.018946 | 1.722 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.018946 | 1.722 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.018946 | 1.722 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.017574 | 1.755 |
| R-HSA-9909396 | Circadian clock | 0.014388 | 1.842 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.017574 | 1.755 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 0.013154 | 1.881 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 0.013154 | 1.881 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 0.013154 | 1.881 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 0.017574 | 1.755 |
| R-HSA-75153 | Apoptotic execution phase | 0.015466 | 1.811 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.020360 | 1.691 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.021249 | 1.673 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.020821 | 1.681 |
| R-HSA-3214847 | HATs acetylate histones | 0.021890 | 1.660 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.022534 | 1.647 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.023090 | 1.637 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.024043 | 1.619 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.026119 | 1.583 |
| R-HSA-199991 | Membrane Trafficking | 0.027698 | 1.558 |
| R-HSA-983189 | Kinesins | 0.028062 | 1.552 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.028285 | 1.548 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.030197 | 1.520 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.033927 | 1.469 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.033927 | 1.469 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.031296 | 1.505 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.036008 | 1.444 |
| R-HSA-8941237 | Invadopodia formation | 0.046699 | 1.331 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.091231 | 1.040 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.133695 | 0.874 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.133695 | 0.874 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.141948 | 0.848 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.141948 | 0.848 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.174188 | 0.759 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.174188 | 0.759 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.189853 | 0.722 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.205223 | 0.688 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.205223 | 0.688 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.212799 | 0.672 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.212799 | 0.672 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.212799 | 0.672 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.212799 | 0.672 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.212799 | 0.672 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.094975 | 1.022 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.227737 | 0.643 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.227737 | 0.643 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.097933 | 1.009 |
| R-HSA-429947 | Deadenylation of mRNA | 0.249616 | 0.603 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.116198 | 0.935 |
| R-HSA-72649 | Translation initiation complex formation | 0.119322 | 0.923 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.256772 | 0.590 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.062155 | 1.207 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.062155 | 1.207 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.125631 | 0.901 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.066934 | 1.174 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.284722 | 0.546 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.284722 | 0.546 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.148295 | 0.829 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.148295 | 0.829 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.154916 | 0.810 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.158248 | 0.801 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.108687 | 0.964 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.181918 | 0.740 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.324702 | 0.489 |
| R-HSA-380287 | Centrosome maturation | 0.188776 | 0.724 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.251661 | 0.599 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.279892 | 0.553 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.315061 | 0.502 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.129337 | 0.888 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.244610 | 0.612 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.129337 | 0.888 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.269305 | 0.570 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.132018 | 0.879 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.324702 | 0.489 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.040830 | 1.389 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.040830 | 1.389 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 0.064766 | 1.189 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 0.141948 | 0.848 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 0.141948 | 0.848 |
| R-HSA-9857492 | Protein lipoylation | 0.166242 | 0.779 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.064372 | 1.191 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.270880 | 0.567 |
| R-HSA-9620244 | Long-term potentiation | 0.256772 | 0.590 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.209547 | 0.679 |
| R-HSA-6783984 | Glycine degradation | 0.182057 | 0.740 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.189853 | 0.722 |
| R-HSA-1221632 | Meiotic synapsis | 0.116198 | 0.935 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.291545 | 0.535 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.311628 | 0.506 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.108687 | 0.964 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.272835 | 0.564 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.318196 | 0.497 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.263860 | 0.579 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.141948 | 0.848 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.051829 | 1.285 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.311628 | 0.506 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.080600 | 1.094 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.041499 | 1.382 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 0.092043 | 1.036 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.091231 | 1.040 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.116951 | 0.932 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.150124 | 0.824 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.197574 | 0.704 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.227737 | 0.643 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.235099 | 0.629 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.119322 | 0.923 |
| R-HSA-8949613 | Cristae formation | 0.270880 | 0.567 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.277834 | 0.556 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.298303 | 0.525 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.324702 | 0.489 |
| R-HSA-69541 | Stabilization of p53 | 0.072337 | 1.141 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.049679 | 1.304 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.059062 | 1.229 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.263860 | 0.579 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.171705 | 0.765 |
| R-HSA-1500620 | Meiosis | 0.223523 | 0.651 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.301025 | 0.521 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.265775 | 0.575 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.135240 | 0.869 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.210401 | 0.677 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.158221 | 0.801 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 0.182057 | 0.740 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.197574 | 0.704 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.291545 | 0.535 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.304998 | 0.516 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.331146 | 0.480 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.331146 | 0.480 |
| R-HSA-68875 | Mitotic Prophase | 0.137961 | 0.860 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.103925 | 0.983 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.103925 | 0.983 |
| R-HSA-72312 | rRNA processing | 0.095537 | 1.020 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.116198 | 0.935 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.116951 | 0.932 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.100916 | 0.996 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.108459 | 0.965 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.072337 | 1.141 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.181918 | 0.740 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.161593 | 0.792 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.311628 | 0.506 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.331146 | 0.480 |
| R-HSA-9711097 | Cellular response to starvation | 0.237877 | 0.624 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.311628 | 0.506 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.064766 | 1.189 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.133695 | 0.874 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.141948 | 0.848 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 0.166242 | 0.779 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.042114 | 1.376 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.242392 | 0.615 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 0.270880 | 0.567 |
| R-HSA-69481 | G2/M Checkpoints | 0.048322 | 1.316 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.298303 | 0.525 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.110690 | 0.956 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.185342 | 0.732 |
| R-HSA-9612973 | Autophagy | 0.232832 | 0.633 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.148295 | 0.829 |
| R-HSA-5578775 | Ion homeostasis | 0.125631 | 0.901 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.311628 | 0.506 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.318196 | 0.497 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.092043 | 1.036 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.206068 | 0.686 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.099886 | 1.000 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.189853 | 0.722 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.212799 | 0.672 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.311628 | 0.506 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.318196 | 0.497 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.110690 | 0.956 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.324702 | 0.489 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.324702 | 0.489 |
| R-HSA-169911 | Regulation of Apoptosis | 0.331146 | 0.480 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.262246 | 0.581 |
| R-HSA-5617833 | Cilium Assembly | 0.322981 | 0.491 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.223523 | 0.651 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.063730 | 1.196 |
| R-HSA-112043 | PLC beta mediated events | 0.141735 | 0.849 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.242940 | 0.615 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.084020 | 1.076 |
| R-HSA-381042 | PERK regulates gene expression | 0.331146 | 0.480 |
| R-HSA-69275 | G2/M Transition | 0.134637 | 0.871 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.138035 | 0.860 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.050236 | 1.299 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.101085 | 0.995 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.108459 | 0.965 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.158221 | 0.801 |
| R-HSA-9755088 | Ribavirin ADME | 0.227737 | 0.643 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.256772 | 0.590 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.263860 | 0.579 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.108687 | 0.964 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.060282 | 1.220 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.227029 | 0.644 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.331146 | 0.480 |
| R-HSA-9659379 | Sensory processing of sound | 0.202595 | 0.693 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.227174 | 0.644 |
| R-HSA-69306 | DNA Replication | 0.225304 | 0.647 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.222805 | 0.652 |
| R-HSA-112040 | G-protein mediated events | 0.161593 | 0.792 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.064766 | 1.189 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.220303 | 0.657 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.227737 | 0.643 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.298303 | 0.525 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.164952 | 0.783 |
| R-HSA-69242 | S Phase | 0.212869 | 0.672 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 0.108459 | 0.965 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.040302 | 1.395 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.235099 | 0.629 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.125631 | 0.901 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.284722 | 0.546 |
| R-HSA-354192 | Integrin signaling | 0.311628 | 0.506 |
| R-HSA-9707616 | Heme signaling | 0.145007 | 0.839 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.178503 | 0.748 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.125363 | 0.902 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.311628 | 0.506 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.169573 | 0.771 |
| R-HSA-69239 | Synthesis of DNA | 0.315061 | 0.502 |
| R-HSA-2559583 | Cellular Senescence | 0.296956 | 0.527 |
| R-HSA-111885 | Opioid Signalling | 0.301025 | 0.521 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.113438 | 0.945 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.185535 | 0.732 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.283990 | 0.547 |
| R-HSA-5688426 | Deubiquitination | 0.125141 | 0.903 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.272835 | 0.564 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.258717 | 0.587 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.158221 | 0.801 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.197574 | 0.704 |
| R-HSA-5673000 | RAF activation | 0.324702 | 0.489 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.237569 | 0.624 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.286944 | 0.542 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.311628 | 0.506 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.318196 | 0.497 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.281402 | 0.551 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.097953 | 1.009 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.220312 | 0.657 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.073217 | 1.135 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.086264 | 1.064 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.181918 | 0.740 |
| R-HSA-4839726 | Chromatin organization | 0.117042 | 0.932 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.276364 | 0.559 |
| R-HSA-186763 | Downstream signal transduction | 0.298303 | 0.525 |
| R-HSA-190861 | Gap junction assembly | 0.324702 | 0.489 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.188776 | 0.724 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.209547 | 0.679 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.072337 | 1.141 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.075059 | 1.125 |
| R-HSA-264876 | Insulin processing | 0.270880 | 0.567 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.148295 | 0.829 |
| R-HSA-8848021 | Signaling by PTK6 | 0.148295 | 0.829 |
| R-HSA-422475 | Axon guidance | 0.176437 | 0.753 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.256772 | 0.590 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.256772 | 0.590 |
| R-HSA-9675108 | Nervous system development | 0.221436 | 0.655 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.106698 | 0.972 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.227808 | 0.642 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.106698 | 0.972 |
| R-HSA-109581 | Apoptosis | 0.095323 | 1.021 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.185342 | 0.732 |
| R-HSA-5357801 | Programmed Cell Death | 0.170089 | 0.769 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.227808 | 0.642 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.154916 | 0.810 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.075260 | 1.123 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.192219 | 0.716 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.234052 | 0.631 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.332518 | 0.478 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.332518 | 0.478 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.337529 | 0.472 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.337529 | 0.472 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.337529 | 0.472 |
| R-HSA-111933 | Calmodulin induced events | 0.337529 | 0.472 |
| R-HSA-111997 | CaM pathway | 0.337529 | 0.472 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.337529 | 0.472 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.339466 | 0.469 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.342933 | 0.465 |
| R-HSA-4641258 | Degradation of DVL | 0.343851 | 0.464 |
| R-HSA-4641257 | Degradation of AXIN | 0.343851 | 0.464 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.343851 | 0.464 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.346393 | 0.460 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.349848 | 0.456 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.350113 | 0.456 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.354226 | 0.451 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.356316 | 0.448 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.356316 | 0.448 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.356316 | 0.448 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.356739 | 0.448 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.356825 | 0.448 |
| R-HSA-5693538 | Homology Directed Repair | 0.360175 | 0.443 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.362460 | 0.441 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.362460 | 0.441 |
| R-HSA-9646399 | Aggrephagy | 0.362460 | 0.441 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.362460 | 0.441 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.363604 | 0.439 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.368546 | 0.434 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.368546 | 0.434 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.368546 | 0.434 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.368546 | 0.434 |
| R-HSA-9694548 | Maturation of spike protein | 0.368546 | 0.434 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.368546 | 0.434 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.370442 | 0.431 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.374574 | 0.426 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.374574 | 0.426 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.374574 | 0.426 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.374574 | 0.426 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.374574 | 0.426 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.374574 | 0.426 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.374574 | 0.426 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.377251 | 0.423 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.380545 | 0.420 |
| R-HSA-111996 | Ca-dependent events | 0.380545 | 0.420 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.380545 | 0.420 |
| R-HSA-165159 | MTOR signalling | 0.380545 | 0.420 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.386460 | 0.413 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.386460 | 0.413 |
| R-HSA-69206 | G1/S Transition | 0.387407 | 0.412 |
| R-HSA-194138 | Signaling by VEGF | 0.387407 | 0.412 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.392318 | 0.406 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.392318 | 0.406 |
| R-HSA-9907900 | Proteasome assembly | 0.392318 | 0.406 |
| R-HSA-190828 | Gap junction trafficking | 0.392318 | 0.406 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.398121 | 0.400 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.398121 | 0.400 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.398121 | 0.400 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.398121 | 0.400 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.398121 | 0.400 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.398121 | 0.400 |
| R-HSA-9824272 | Somitogenesis | 0.398121 | 0.400 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.403868 | 0.394 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.403868 | 0.394 |
| R-HSA-9675135 | Diseases of DNA repair | 0.403868 | 0.394 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.403868 | 0.394 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.403868 | 0.394 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.403868 | 0.394 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.403868 | 0.394 |
| R-HSA-1474165 | Reproduction | 0.407499 | 0.390 |
| R-HSA-2262752 | Cellular responses to stress | 0.408689 | 0.389 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.409561 | 0.388 |
| R-HSA-437239 | Recycling pathway of L1 | 0.409561 | 0.388 |
| R-HSA-5576891 | Cardiac conduction | 0.410817 | 0.386 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.414127 | 0.383 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.415960 | 0.381 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.420786 | 0.376 |
| R-HSA-9766229 | Degradation of CDH1 | 0.420786 | 0.376 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.420786 | 0.376 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.420786 | 0.376 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.426318 | 0.370 |
| R-HSA-9748787 | Azathioprine ADME | 0.426318 | 0.370 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.430534 | 0.366 |
| R-HSA-72766 | Translation | 0.431072 | 0.365 |
| R-HSA-912446 | Meiotic recombination | 0.431798 | 0.365 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.431798 | 0.365 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.431798 | 0.365 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.431798 | 0.365 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.431798 | 0.365 |
| R-HSA-8953854 | Metabolism of RNA | 0.434124 | 0.362 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.437029 | 0.359 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.437226 | 0.359 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.437226 | 0.359 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.437226 | 0.359 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.437226 | 0.359 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.442603 | 0.354 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.442603 | 0.354 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.442603 | 0.354 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.442603 | 0.354 |
| R-HSA-9664407 | Parasite infection | 0.443484 | 0.353 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.443484 | 0.353 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.443484 | 0.353 |
| R-HSA-1632852 | Macroautophagy | 0.446697 | 0.350 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.446697 | 0.350 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.463603 | 0.334 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.463603 | 0.334 |
| R-HSA-1483166 | Synthesis of PA | 0.463603 | 0.334 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.465753 | 0.332 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.473807 | 0.324 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.478242 | 0.320 |
| R-HSA-351202 | Metabolism of polyamines | 0.478836 | 0.320 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.478836 | 0.320 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.478836 | 0.320 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.478836 | 0.320 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.478836 | 0.320 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.478836 | 0.320 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.483817 | 0.315 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.483817 | 0.315 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.483817 | 0.315 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.487492 | 0.312 |
| R-HSA-1268020 | Mitochondrial protein import | 0.488752 | 0.311 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.488752 | 0.311 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.488752 | 0.311 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.488752 | 0.311 |
| R-HSA-186797 | Signaling by PDGF | 0.488752 | 0.311 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.498480 | 0.302 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.498480 | 0.302 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.502682 | 0.299 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.503275 | 0.298 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.503275 | 0.298 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.509487 | 0.293 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.512728 | 0.290 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.521218 | 0.283 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.526574 | 0.279 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.526574 | 0.279 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.526574 | 0.279 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.531102 | 0.275 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.531102 | 0.275 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.531102 | 0.275 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.531102 | 0.275 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.535587 | 0.271 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.535587 | 0.271 |
| R-HSA-4086398 | Ca2+ pathway | 0.540030 | 0.268 |
| R-HSA-913531 | Interferon Signaling | 0.541660 | 0.266 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.543650 | 0.265 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 0.544430 | 0.264 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.544430 | 0.264 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.544430 | 0.264 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.546486 | 0.262 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.549309 | 0.260 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.549309 | 0.260 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.549309 | 0.260 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.549309 | 0.260 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.550999 | 0.259 |
| R-HSA-9658195 | Leishmania infection | 0.550999 | 0.259 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.553105 | 0.257 |
| R-HSA-5689603 | UCH proteinases | 0.553105 | 0.257 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.553105 | 0.257 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.553245 | 0.257 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.557381 | 0.254 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.561616 | 0.251 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.561616 | 0.251 |
| R-HSA-5619084 | ABC transporter disorders | 0.561616 | 0.251 |
| R-HSA-4086400 | PCP/CE pathway | 0.561616 | 0.251 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.563125 | 0.249 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.567822 | 0.246 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.569966 | 0.244 |
| R-HSA-9833482 | PKR-mediated signaling | 0.569966 | 0.244 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.578158 | 0.238 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.582195 | 0.235 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.586194 | 0.232 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.590156 | 0.229 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.590156 | 0.229 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.594079 | 0.226 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.600614 | 0.221 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.601815 | 0.221 |
| R-HSA-156902 | Peptide chain elongation | 0.605627 | 0.218 |
| R-HSA-9663891 | Selective autophagy | 0.605627 | 0.218 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.605754 | 0.218 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.609403 | 0.215 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.610843 | 0.214 |
| R-HSA-202424 | Downstream TCR signaling | 0.613144 | 0.212 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.614502 | 0.211 |
| R-HSA-1266738 | Developmental Biology | 0.616622 | 0.210 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.616849 | 0.210 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.616849 | 0.210 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.620873 | 0.207 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.624153 | 0.205 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.624153 | 0.205 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.627753 | 0.202 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.628265 | 0.202 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.628265 | 0.202 |
| R-HSA-72172 | mRNA Splicing | 0.633131 | 0.199 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.634851 | 0.197 |
| R-HSA-74160 | Gene expression (Transcription) | 0.636033 | 0.197 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.638349 | 0.195 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.638349 | 0.195 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.641814 | 0.193 |
| R-HSA-157579 | Telomere Maintenance | 0.645246 | 0.190 |
| R-HSA-422356 | Regulation of insulin secretion | 0.648645 | 0.188 |
| R-HSA-597592 | Post-translational protein modification | 0.649259 | 0.188 |
| R-HSA-212436 | Generic Transcription Pathway | 0.650992 | 0.186 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.654418 | 0.184 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.655347 | 0.184 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.658650 | 0.181 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.658650 | 0.181 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.658650 | 0.181 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.661922 | 0.179 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.661922 | 0.179 |
| R-HSA-192823 | Viral mRNA Translation | 0.665162 | 0.177 |
| R-HSA-418990 | Adherens junctions interactions | 0.665816 | 0.177 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.668372 | 0.175 |
| R-HSA-8951664 | Neddylation | 0.672509 | 0.172 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.675184 | 0.171 |
| R-HSA-418346 | Platelet homeostasis | 0.677819 | 0.169 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.683425 | 0.165 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.683967 | 0.165 |
| R-HSA-202403 | TCR signaling | 0.689999 | 0.161 |
| R-HSA-162582 | Signal Transduction | 0.702488 | 0.153 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.710225 | 0.149 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.710225 | 0.149 |
| R-HSA-157118 | Signaling by NOTCH | 0.712420 | 0.147 |
| R-HSA-373760 | L1CAM interactions | 0.713005 | 0.147 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.715759 | 0.145 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.715759 | 0.145 |
| R-HSA-392499 | Metabolism of proteins | 0.725743 | 0.139 |
| R-HSA-73886 | Chromosome Maintenance | 0.726514 | 0.139 |
| R-HSA-3371556 | Cellular response to heat stress | 0.726514 | 0.139 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.726514 | 0.139 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.726609 | 0.139 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.731739 | 0.136 |
| R-HSA-421270 | Cell-cell junction organization | 0.733624 | 0.135 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.734314 | 0.134 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.734314 | 0.134 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.741893 | 0.130 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.742819 | 0.129 |
| R-HSA-449147 | Signaling by Interleukins | 0.743670 | 0.129 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.744930 | 0.128 |
| R-HSA-9843745 | Adipogenesis | 0.756413 | 0.121 |
| R-HSA-163685 | Integration of energy metabolism | 0.770121 | 0.113 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.771330 | 0.113 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.772330 | 0.112 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.773712 | 0.111 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.774517 | 0.111 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.776684 | 0.110 |
| R-HSA-6807070 | PTEN Regulation | 0.776684 | 0.110 |
| R-HSA-446728 | Cell junction organization | 0.780125 | 0.108 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.781703 | 0.107 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.787213 | 0.104 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.789258 | 0.103 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.796950 | 0.099 |
| R-HSA-9758941 | Gastrulation | 0.799197 | 0.097 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.804936 | 0.094 |
| R-HSA-1483257 | Phospholipid metabolism | 0.805643 | 0.094 |
| R-HSA-9609507 | Protein localization | 0.806812 | 0.093 |
| R-HSA-1280218 | Adaptive Immune System | 0.806862 | 0.093 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.807059 | 0.093 |
| R-HSA-195721 | Signaling by WNT | 0.809865 | 0.092 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.810511 | 0.091 |
| R-HSA-1989781 | PPARA activates gene expression | 0.810511 | 0.091 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.814140 | 0.089 |
| R-HSA-877300 | Interferon gamma signaling | 0.817700 | 0.087 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.826305 | 0.083 |
| R-HSA-1500931 | Cell-Cell communication | 0.833530 | 0.079 |
| R-HSA-72306 | tRNA processing | 0.837679 | 0.077 |
| R-HSA-1474244 | Extracellular matrix organization | 0.851198 | 0.070 |
| R-HSA-168255 | Influenza Infection | 0.851222 | 0.070 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.856874 | 0.067 |
| R-HSA-983712 | Ion channel transport | 0.864956 | 0.063 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.868159 | 0.061 |
| R-HSA-73894 | DNA Repair | 0.880621 | 0.055 |
| R-HSA-6805567 | Keratinization | 0.886579 | 0.052 |
| R-HSA-109582 | Hemostasis | 0.887970 | 0.052 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.892992 | 0.049 |
| R-HSA-9748784 | Drug ADME | 0.899046 | 0.046 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.906096 | 0.043 |
| R-HSA-162906 | HIV Infection | 0.907493 | 0.042 |
| R-HSA-8939211 | ESR-mediated signaling | 0.916058 | 0.038 |
| R-HSA-418594 | G alpha (i) signalling events | 0.917827 | 0.037 |
| R-HSA-8978868 | Fatty acid metabolism | 0.917827 | 0.037 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.923834 | 0.034 |
| R-HSA-416476 | G alpha (q) signalling events | 0.935446 | 0.029 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.946182 | 0.024 |
| R-HSA-112316 | Neuronal System | 0.949571 | 0.022 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.952277 | 0.021 |
| R-HSA-1643685 | Disease | 0.954579 | 0.020 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.963691 | 0.016 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.969551 | 0.013 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.971843 | 0.012 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.975450 | 0.011 |
| R-HSA-168256 | Immune System | 0.979378 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.982583 | 0.008 |
| R-HSA-388396 | GPCR downstream signalling | 0.983244 | 0.007 |
| R-HSA-5663205 | Infectious disease | 0.986315 | 0.006 |
| R-HSA-382551 | Transport of small molecules | 0.988010 | 0.005 |
| R-HSA-6798695 | Neutrophil degranulation | 0.990348 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 0.991272 | 0.004 |
| R-HSA-9824446 | Viral Infection Pathways | 0.996016 | 0.002 |
| R-HSA-9679506 | SARS-CoV Infections | 0.996337 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.999204 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999789 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999949 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.849 | 0.149 | 2 | 0.865 |
CDC7 |
0.837 | 0.097 | 1 | 0.865 |
MOS |
0.836 | 0.166 | 1 | 0.893 |
CLK3 |
0.835 | 0.124 | 1 | 0.814 |
DSTYK |
0.834 | 0.125 | 2 | 0.897 |
PIM3 |
0.832 | 0.049 | -3 | 0.763 |
PRPK |
0.832 | -0.052 | -1 | 0.782 |
NLK |
0.832 | 0.052 | 1 | 0.808 |
GRK1 |
0.831 | 0.211 | -2 | 0.805 |
BMPR1B |
0.828 | 0.217 | 1 | 0.784 |
IKKB |
0.828 | -0.003 | -2 | 0.679 |
GCN2 |
0.827 | -0.093 | 2 | 0.814 |
CAMK2G |
0.826 | 0.039 | 2 | 0.790 |
TBK1 |
0.826 | -0.039 | 1 | 0.733 |
RAF1 |
0.826 | -0.064 | 1 | 0.837 |
BMPR2 |
0.826 | -0.069 | -2 | 0.795 |
ERK5 |
0.825 | 0.035 | 1 | 0.755 |
GRK6 |
0.825 | 0.172 | 1 | 0.820 |
CAMK1B |
0.825 | -0.026 | -3 | 0.793 |
PKN3 |
0.824 | 0.026 | -3 | 0.751 |
MTOR |
0.824 | -0.097 | 1 | 0.787 |
CDKL1 |
0.823 | -0.010 | -3 | 0.724 |
RSK2 |
0.823 | 0.039 | -3 | 0.692 |
TGFBR2 |
0.823 | -0.012 | -2 | 0.755 |
ATR |
0.823 | -0.024 | 1 | 0.806 |
MLK1 |
0.822 | -0.007 | 2 | 0.848 |
IKKE |
0.822 | -0.042 | 1 | 0.731 |
WNK1 |
0.822 | -0.013 | -2 | 0.754 |
ULK2 |
0.822 | -0.118 | 2 | 0.797 |
GRK5 |
0.822 | 0.010 | -3 | 0.830 |
PIM1 |
0.822 | 0.051 | -3 | 0.698 |
NEK6 |
0.821 | -0.018 | -2 | 0.750 |
NUAK2 |
0.821 | -0.008 | -3 | 0.770 |
PDHK4 |
0.820 | -0.232 | 1 | 0.845 |
TGFBR1 |
0.820 | 0.152 | -2 | 0.776 |
NIK |
0.820 | -0.043 | -3 | 0.817 |
GRK7 |
0.820 | 0.231 | 1 | 0.750 |
NEK7 |
0.820 | -0.063 | -3 | 0.809 |
KIS |
0.820 | 0.074 | 1 | 0.674 |
FAM20C |
0.820 | 0.142 | 2 | 0.628 |
NDR2 |
0.820 | -0.021 | -3 | 0.767 |
ALK2 |
0.819 | 0.219 | -2 | 0.791 |
TSSK2 |
0.818 | 0.035 | -5 | 0.824 |
MST4 |
0.818 | 0.009 | 2 | 0.879 |
PKCD |
0.818 | 0.026 | 2 | 0.824 |
HUNK |
0.817 | -0.039 | 2 | 0.774 |
ALK4 |
0.817 | 0.104 | -2 | 0.783 |
CAMLCK |
0.817 | -0.035 | -2 | 0.748 |
PRKD1 |
0.817 | -0.004 | -3 | 0.732 |
PRKD2 |
0.817 | 0.009 | -3 | 0.681 |
IKKA |
0.816 | 0.034 | -2 | 0.677 |
CDKL5 |
0.816 | -0.019 | -3 | 0.710 |
PKN2 |
0.816 | -0.009 | -3 | 0.760 |
MARK4 |
0.816 | -0.027 | 4 | 0.855 |
RIPK3 |
0.815 | -0.110 | 3 | 0.652 |
SRPK1 |
0.815 | 0.016 | -3 | 0.670 |
PDHK1 |
0.815 | -0.189 | 1 | 0.837 |
AMPKA1 |
0.815 | -0.016 | -3 | 0.775 |
MAPKAPK2 |
0.814 | 0.062 | -3 | 0.634 |
NDR1 |
0.814 | -0.057 | -3 | 0.755 |
MAPKAPK3 |
0.814 | -0.002 | -3 | 0.679 |
GRK4 |
0.814 | 0.032 | -2 | 0.786 |
TSSK1 |
0.814 | 0.007 | -3 | 0.800 |
P90RSK |
0.813 | -0.022 | -3 | 0.692 |
PKR |
0.813 | 0.061 | 1 | 0.844 |
CHAK2 |
0.813 | -0.087 | -1 | 0.726 |
CAMK2B |
0.813 | 0.098 | 2 | 0.769 |
SKMLCK |
0.813 | -0.047 | -2 | 0.760 |
BMPR1A |
0.813 | 0.193 | 1 | 0.779 |
TTBK2 |
0.813 | -0.031 | 2 | 0.697 |
WNK3 |
0.812 | -0.162 | 1 | 0.810 |
ATM |
0.812 | 0.025 | 1 | 0.757 |
HIPK4 |
0.812 | -0.019 | 1 | 0.806 |
IRE2 |
0.812 | 0.005 | 2 | 0.780 |
DAPK2 |
0.812 | -0.082 | -3 | 0.799 |
MLK3 |
0.812 | 0.015 | 2 | 0.789 |
LATS2 |
0.812 | -0.009 | -5 | 0.747 |
RSK3 |
0.812 | -0.029 | -3 | 0.684 |
NEK9 |
0.811 | -0.104 | 2 | 0.865 |
ACVR2A |
0.811 | 0.079 | -2 | 0.737 |
IRE1 |
0.811 | -0.054 | 1 | 0.802 |
P70S6KB |
0.811 | -0.019 | -3 | 0.713 |
ULK1 |
0.810 | -0.145 | -3 | 0.783 |
ICK |
0.810 | -0.048 | -3 | 0.761 |
CAMK2D |
0.809 | -0.043 | -3 | 0.758 |
PKACG |
0.809 | -0.033 | -2 | 0.661 |
ACVR2B |
0.809 | 0.077 | -2 | 0.749 |
PLK1 |
0.808 | 0.005 | -2 | 0.720 |
SRPK3 |
0.808 | 0.010 | -3 | 0.642 |
MLK2 |
0.807 | -0.136 | 2 | 0.850 |
CK2A2 |
0.807 | 0.318 | 1 | 0.717 |
PLK3 |
0.807 | 0.056 | 2 | 0.727 |
ANKRD3 |
0.807 | -0.154 | 1 | 0.835 |
RSK4 |
0.806 | 0.037 | -3 | 0.660 |
MLK4 |
0.806 | -0.007 | 2 | 0.769 |
BCKDK |
0.806 | -0.150 | -1 | 0.682 |
AMPKA2 |
0.806 | -0.039 | -3 | 0.737 |
DLK |
0.806 | -0.162 | 1 | 0.798 |
LATS1 |
0.806 | 0.021 | -3 | 0.794 |
PRKD3 |
0.805 | -0.028 | -3 | 0.655 |
NIM1 |
0.805 | -0.110 | 3 | 0.685 |
AURC |
0.805 | -0.005 | -2 | 0.596 |
CDK8 |
0.805 | -0.016 | 1 | 0.634 |
PKCB |
0.805 | 0.002 | 2 | 0.791 |
JNK2 |
0.804 | 0.066 | 1 | 0.596 |
PKCA |
0.804 | 0.011 | 2 | 0.784 |
JNK3 |
0.804 | 0.056 | 1 | 0.637 |
SRPK2 |
0.804 | -0.007 | -3 | 0.586 |
RIPK1 |
0.804 | -0.181 | 1 | 0.818 |
DNAPK |
0.803 | 0.036 | 1 | 0.713 |
CAMK4 |
0.803 | -0.088 | -3 | 0.738 |
CAMK2A |
0.803 | 0.030 | 2 | 0.774 |
PKCG |
0.803 | -0.013 | 2 | 0.772 |
CDK1 |
0.803 | 0.040 | 1 | 0.605 |
AURB |
0.803 | -0.004 | -2 | 0.591 |
NUAK1 |
0.802 | -0.066 | -3 | 0.706 |
CDK5 |
0.802 | 0.024 | 1 | 0.666 |
CLK4 |
0.802 | -0.004 | -3 | 0.686 |
NEK2 |
0.802 | -0.052 | 2 | 0.845 |
DYRK2 |
0.802 | -0.000 | 1 | 0.703 |
PAK1 |
0.802 | -0.043 | -2 | 0.683 |
PERK |
0.802 | -0.043 | -2 | 0.776 |
MASTL |
0.802 | -0.304 | -2 | 0.719 |
P38A |
0.801 | 0.018 | 1 | 0.672 |
MELK |
0.801 | -0.077 | -3 | 0.716 |
MEK1 |
0.801 | -0.151 | 2 | 0.822 |
QIK |
0.801 | -0.104 | -3 | 0.759 |
PIM2 |
0.801 | 0.015 | -3 | 0.659 |
YSK4 |
0.800 | -0.088 | 1 | 0.760 |
CLK1 |
0.800 | 0.004 | -3 | 0.662 |
PKCH |
0.800 | -0.026 | 2 | 0.770 |
QSK |
0.800 | -0.041 | 4 | 0.838 |
CLK2 |
0.800 | 0.064 | -3 | 0.672 |
CDK2 |
0.800 | 0.019 | 1 | 0.680 |
PKACB |
0.799 | 0.009 | -2 | 0.602 |
PAK3 |
0.799 | -0.087 | -2 | 0.677 |
ERK1 |
0.799 | 0.023 | 1 | 0.596 |
SGK3 |
0.799 | -0.001 | -3 | 0.673 |
VRK2 |
0.799 | -0.242 | 1 | 0.855 |
PKG2 |
0.799 | -0.018 | -2 | 0.599 |
MNK2 |
0.799 | -0.064 | -2 | 0.685 |
P38B |
0.798 | 0.033 | 1 | 0.602 |
HIPK1 |
0.798 | 0.023 | 1 | 0.717 |
PHKG1 |
0.798 | -0.077 | -3 | 0.741 |
GRK2 |
0.798 | -0.026 | -2 | 0.688 |
PAK6 |
0.798 | 0.002 | -2 | 0.611 |
SMG1 |
0.798 | -0.054 | 1 | 0.761 |
CDK19 |
0.798 | -0.018 | 1 | 0.595 |
PKCZ |
0.797 | -0.064 | 2 | 0.818 |
ERK2 |
0.797 | 0.003 | 1 | 0.647 |
CHAK1 |
0.797 | -0.133 | 2 | 0.778 |
MYLK4 |
0.797 | -0.048 | -2 | 0.689 |
MARK2 |
0.797 | -0.022 | 4 | 0.785 |
TLK2 |
0.797 | -0.060 | 1 | 0.777 |
CDK7 |
0.797 | -0.042 | 1 | 0.652 |
MSK2 |
0.796 | -0.074 | -3 | 0.646 |
AURA |
0.796 | 0.000 | -2 | 0.580 |
P38G |
0.796 | 0.033 | 1 | 0.522 |
CDK13 |
0.796 | -0.021 | 1 | 0.631 |
CK1E |
0.796 | 0.025 | -3 | 0.551 |
HRI |
0.796 | -0.120 | -2 | 0.752 |
BRAF |
0.795 | -0.040 | -4 | 0.794 |
SIK |
0.795 | -0.065 | -3 | 0.673 |
SSTK |
0.795 | -0.004 | 4 | 0.820 |
MARK3 |
0.795 | -0.026 | 4 | 0.808 |
CDK3 |
0.795 | 0.062 | 1 | 0.548 |
MPSK1 |
0.795 | 0.029 | 1 | 0.770 |
HIPK2 |
0.795 | 0.019 | 1 | 0.620 |
MNK1 |
0.795 | -0.053 | -2 | 0.698 |
PAK2 |
0.794 | -0.080 | -2 | 0.671 |
MSK1 |
0.794 | -0.032 | -3 | 0.652 |
AKT2 |
0.794 | -0.025 | -3 | 0.603 |
CK2A1 |
0.794 | 0.266 | 1 | 0.691 |
PRKX |
0.793 | 0.022 | -3 | 0.597 |
CHK1 |
0.793 | -0.066 | -3 | 0.744 |
PRP4 |
0.793 | 0.016 | -3 | 0.742 |
CAMK1G |
0.793 | -0.051 | -3 | 0.675 |
TLK1 |
0.793 | -0.033 | -2 | 0.774 |
MEKK3 |
0.793 | -0.092 | 1 | 0.771 |
CDK18 |
0.793 | -0.009 | 1 | 0.582 |
BRSK1 |
0.792 | -0.076 | -3 | 0.704 |
MEKK2 |
0.792 | -0.081 | 2 | 0.829 |
WNK4 |
0.792 | -0.113 | -2 | 0.728 |
ERK7 |
0.792 | 0.085 | 2 | 0.628 |
PINK1 |
0.792 | -0.115 | 1 | 0.818 |
MEKK1 |
0.792 | -0.134 | 1 | 0.785 |
IRAK4 |
0.791 | -0.112 | 1 | 0.805 |
NEK5 |
0.791 | -0.110 | 1 | 0.808 |
MST3 |
0.790 | -0.021 | 2 | 0.857 |
CAMKK1 |
0.790 | -0.024 | -2 | 0.716 |
CK1D |
0.790 | 0.036 | -3 | 0.503 |
GRK3 |
0.790 | 0.011 | -2 | 0.668 |
MARK1 |
0.790 | -0.062 | 4 | 0.822 |
MEK5 |
0.789 | -0.231 | 2 | 0.830 |
EEF2K |
0.789 | 0.064 | 3 | 0.802 |
ZAK |
0.789 | -0.132 | 1 | 0.762 |
P38D |
0.789 | 0.041 | 1 | 0.549 |
CDK12 |
0.789 | -0.022 | 1 | 0.604 |
DRAK1 |
0.789 | -0.106 | 1 | 0.728 |
DYRK1A |
0.789 | -0.032 | 1 | 0.728 |
HIPK3 |
0.788 | -0.029 | 1 | 0.710 |
PKCT |
0.788 | -0.047 | 2 | 0.781 |
DCAMKL1 |
0.788 | -0.078 | -3 | 0.704 |
CDK17 |
0.788 | -0.014 | 1 | 0.529 |
BRSK2 |
0.788 | -0.125 | -3 | 0.728 |
GAK |
0.787 | 0.015 | 1 | 0.806 |
TAO3 |
0.787 | -0.060 | 1 | 0.774 |
CDK9 |
0.787 | -0.047 | 1 | 0.639 |
PKACA |
0.787 | -0.008 | -2 | 0.563 |
SNRK |
0.787 | -0.196 | 2 | 0.670 |
AKT1 |
0.786 | -0.013 | -3 | 0.619 |
PLK4 |
0.786 | -0.138 | 2 | 0.591 |
TTBK1 |
0.786 | -0.096 | 2 | 0.599 |
NEK8 |
0.786 | -0.089 | 2 | 0.840 |
PHKG2 |
0.786 | -0.065 | -3 | 0.721 |
CDK16 |
0.785 | 0.014 | 1 | 0.549 |
PASK |
0.785 | -0.042 | -3 | 0.786 |
SMMLCK |
0.785 | -0.083 | -3 | 0.736 |
P70S6K |
0.785 | -0.040 | -3 | 0.612 |
TAO2 |
0.785 | -0.065 | 2 | 0.869 |
CDK14 |
0.784 | -0.018 | 1 | 0.625 |
GSK3A |
0.784 | 0.010 | 4 | 0.407 |
MAPKAPK5 |
0.784 | -0.144 | -3 | 0.618 |
PKCI |
0.784 | -0.041 | 2 | 0.791 |
CK1G1 |
0.783 | -0.026 | -3 | 0.558 |
CAMKK2 |
0.783 | -0.061 | -2 | 0.712 |
DYRK3 |
0.783 | -0.011 | 1 | 0.730 |
CAMK1D |
0.783 | -0.033 | -3 | 0.586 |
CK1A2 |
0.783 | -0.002 | -3 | 0.499 |
PLK2 |
0.783 | 0.047 | -3 | 0.782 |
DYRK4 |
0.782 | 0.000 | 1 | 0.620 |
DYRK1B |
0.782 | -0.012 | 1 | 0.639 |
JNK1 |
0.782 | 0.033 | 1 | 0.588 |
PKCE |
0.781 | -0.006 | 2 | 0.764 |
CDK10 |
0.781 | 0.012 | 1 | 0.612 |
TAK1 |
0.780 | -0.013 | 1 | 0.806 |
TNIK |
0.780 | 0.003 | 3 | 0.790 |
GSK3B |
0.780 | -0.047 | 4 | 0.395 |
DAPK3 |
0.780 | -0.034 | -3 | 0.719 |
DCAMKL2 |
0.780 | -0.101 | -3 | 0.730 |
NEK4 |
0.779 | -0.104 | 1 | 0.780 |
PDK1 |
0.778 | -0.109 | 1 | 0.812 |
CDK6 |
0.778 | 0.013 | 1 | 0.607 |
HGK |
0.777 | -0.056 | 3 | 0.784 |
MINK |
0.777 | -0.047 | 1 | 0.774 |
MST2 |
0.777 | -0.079 | 1 | 0.774 |
NEK11 |
0.776 | -0.197 | 1 | 0.776 |
PAK5 |
0.776 | -0.057 | -2 | 0.570 |
GCK |
0.776 | -0.057 | 1 | 0.769 |
IRAK1 |
0.775 | -0.255 | -1 | 0.676 |
NEK1 |
0.775 | -0.085 | 1 | 0.794 |
LKB1 |
0.775 | -0.121 | -3 | 0.781 |
PKN1 |
0.775 | -0.046 | -3 | 0.633 |
CDK4 |
0.774 | 0.001 | 1 | 0.594 |
LRRK2 |
0.774 | -0.133 | 2 | 0.856 |
MOK |
0.774 | 0.020 | 1 | 0.734 |
MEKK6 |
0.774 | -0.161 | 1 | 0.758 |
MAP3K15 |
0.774 | -0.144 | 1 | 0.752 |
LOK |
0.774 | -0.080 | -2 | 0.677 |
SGK1 |
0.773 | -0.011 | -3 | 0.515 |
AKT3 |
0.773 | -0.019 | -3 | 0.534 |
BUB1 |
0.773 | 0.030 | -5 | 0.781 |
CAMK1A |
0.772 | -0.035 | -3 | 0.560 |
HPK1 |
0.772 | -0.051 | 1 | 0.764 |
MAK |
0.772 | 0.009 | -2 | 0.650 |
PAK4 |
0.771 | -0.051 | -2 | 0.584 |
MRCKB |
0.771 | -0.026 | -3 | 0.646 |
KHS2 |
0.771 | 0.019 | 1 | 0.777 |
VRK1 |
0.771 | -0.157 | 2 | 0.821 |
DAPK1 |
0.771 | -0.053 | -3 | 0.698 |
CHK2 |
0.771 | -0.061 | -3 | 0.544 |
MST1 |
0.771 | -0.078 | 1 | 0.766 |
ROCK2 |
0.770 | -0.022 | -3 | 0.698 |
KHS1 |
0.770 | -0.025 | 1 | 0.772 |
MRCKA |
0.769 | -0.034 | -3 | 0.664 |
YSK1 |
0.767 | -0.083 | 2 | 0.853 |
TTK |
0.767 | -0.026 | -2 | 0.755 |
PDHK3_TYR |
0.766 | 0.166 | 4 | 0.872 |
DMPK1 |
0.766 | 0.000 | -3 | 0.682 |
SLK |
0.766 | -0.102 | -2 | 0.643 |
MEK2 |
0.765 | -0.226 | 2 | 0.806 |
ALPHAK3 |
0.763 | 0.051 | -1 | 0.680 |
STK33 |
0.763 | -0.164 | 2 | 0.587 |
HASPIN |
0.762 | -0.021 | -1 | 0.609 |
OSR1 |
0.762 | -0.054 | 2 | 0.824 |
ROCK1 |
0.760 | -0.023 | -3 | 0.659 |
PBK |
0.759 | -0.094 | 1 | 0.723 |
BIKE |
0.759 | -0.011 | 1 | 0.683 |
SBK |
0.759 | -0.049 | -3 | 0.480 |
RIPK2 |
0.758 | -0.264 | 1 | 0.726 |
MYO3B |
0.758 | -0.041 | 2 | 0.855 |
PDHK4_TYR |
0.758 | 0.080 | 2 | 0.855 |
CRIK |
0.757 | -0.013 | -3 | 0.616 |
PKG1 |
0.756 | -0.079 | -2 | 0.522 |
NEK3 |
0.756 | -0.194 | 1 | 0.747 |
MYO3A |
0.755 | -0.064 | 1 | 0.787 |
TESK1_TYR |
0.755 | -0.085 | 3 | 0.798 |
MAP2K4_TYR |
0.753 | -0.073 | -1 | 0.789 |
MAP2K7_TYR |
0.753 | -0.126 | 2 | 0.843 |
MAP2K6_TYR |
0.753 | -0.016 | -1 | 0.784 |
PDHK1_TYR |
0.753 | 0.029 | -1 | 0.808 |
PINK1_TYR |
0.752 | -0.088 | 1 | 0.828 |
ASK1 |
0.751 | -0.159 | 1 | 0.747 |
BMPR2_TYR |
0.751 | -0.039 | -1 | 0.755 |
PKMYT1_TYR |
0.750 | -0.151 | 3 | 0.755 |
TAO1 |
0.750 | -0.112 | 1 | 0.718 |
EPHA6 |
0.749 | 0.016 | -1 | 0.764 |
LIMK2_TYR |
0.747 | -0.102 | -3 | 0.830 |
YANK3 |
0.746 | -0.089 | 2 | 0.355 |
YES1 |
0.745 | -0.011 | -1 | 0.812 |
RET |
0.745 | -0.118 | 1 | 0.793 |
TYK2 |
0.744 | -0.134 | 1 | 0.793 |
TXK |
0.744 | 0.046 | 1 | 0.780 |
AAK1 |
0.744 | 0.016 | 1 | 0.578 |
CK1A |
0.743 | -0.029 | -3 | 0.423 |
ABL2 |
0.743 | -0.037 | -1 | 0.772 |
ROS1 |
0.742 | -0.122 | 3 | 0.667 |
TYRO3 |
0.741 | -0.149 | 3 | 0.699 |
STLK3 |
0.741 | -0.154 | 1 | 0.723 |
LCK |
0.741 | 0.019 | -1 | 0.786 |
BLK |
0.740 | 0.053 | -1 | 0.802 |
CSF1R |
0.740 | -0.110 | 3 | 0.686 |
JAK2 |
0.740 | -0.146 | 1 | 0.786 |
LIMK1_TYR |
0.739 | -0.235 | 2 | 0.855 |
EPHB4 |
0.739 | -0.077 | -1 | 0.757 |
FGR |
0.739 | -0.066 | 1 | 0.782 |
FER |
0.739 | -0.061 | 1 | 0.830 |
HCK |
0.738 | -0.045 | -1 | 0.785 |
MST1R |
0.738 | -0.188 | 3 | 0.701 |
ABL1 |
0.737 | -0.075 | -1 | 0.769 |
CK1G3 |
0.736 | -0.008 | -3 | 0.380 |
INSRR |
0.735 | -0.097 | 3 | 0.652 |
EPHA4 |
0.735 | -0.024 | 2 | 0.719 |
TNNI3K_TYR |
0.735 | -0.036 | 1 | 0.783 |
FLT3 |
0.734 | -0.102 | 3 | 0.697 |
TEC |
0.734 | -0.021 | -1 | 0.716 |
SRMS |
0.734 | -0.051 | 1 | 0.810 |
DDR1 |
0.734 | -0.213 | 4 | 0.798 |
NEK10_TYR |
0.733 | -0.092 | 1 | 0.694 |
JAK3 |
0.733 | -0.148 | 1 | 0.774 |
JAK1 |
0.732 | -0.078 | 1 | 0.739 |
TNK2 |
0.731 | -0.136 | 3 | 0.652 |
WEE1_TYR |
0.731 | -0.052 | -1 | 0.670 |
FYN |
0.731 | 0.018 | -1 | 0.757 |
ITK |
0.731 | -0.101 | -1 | 0.745 |
KIT |
0.731 | -0.135 | 3 | 0.692 |
KDR |
0.730 | -0.134 | 3 | 0.660 |
FRK |
0.729 | -0.016 | -1 | 0.818 |
MERTK |
0.729 | -0.092 | 3 | 0.667 |
BTK |
0.729 | -0.130 | -1 | 0.732 |
EPHB2 |
0.729 | -0.053 | -1 | 0.747 |
PDGFRB |
0.729 | -0.200 | 3 | 0.704 |
FGFR2 |
0.728 | -0.170 | 3 | 0.695 |
TEK |
0.728 | -0.152 | 3 | 0.639 |
EPHB1 |
0.728 | -0.114 | 1 | 0.799 |
EPHB3 |
0.728 | -0.089 | -1 | 0.752 |
BMX |
0.726 | -0.072 | -1 | 0.684 |
TNK1 |
0.726 | -0.194 | 3 | 0.670 |
AXL |
0.725 | -0.171 | 3 | 0.669 |
MET |
0.724 | -0.126 | 3 | 0.672 |
LYN |
0.724 | -0.061 | 3 | 0.627 |
ALK |
0.724 | -0.144 | 3 | 0.622 |
FGFR1 |
0.724 | -0.190 | 3 | 0.670 |
ERBB2 |
0.724 | -0.121 | 1 | 0.744 |
PDGFRA |
0.722 | -0.241 | 3 | 0.701 |
PTK6 |
0.722 | -0.176 | -1 | 0.686 |
LTK |
0.722 | -0.145 | 3 | 0.641 |
FLT1 |
0.722 | -0.117 | -1 | 0.726 |
EPHA7 |
0.721 | -0.085 | 2 | 0.731 |
FGFR3 |
0.718 | -0.153 | 3 | 0.672 |
MATK |
0.718 | -0.101 | -1 | 0.700 |
SRC |
0.718 | -0.060 | -1 | 0.773 |
EPHA1 |
0.718 | -0.151 | 3 | 0.653 |
EPHA3 |
0.716 | -0.157 | 2 | 0.698 |
SYK |
0.716 | 0.040 | -1 | 0.673 |
YANK2 |
0.716 | -0.111 | 2 | 0.381 |
EGFR |
0.715 | -0.057 | 1 | 0.648 |
EPHA5 |
0.715 | -0.067 | 2 | 0.708 |
NTRK1 |
0.715 | -0.232 | -1 | 0.723 |
CK1G2 |
0.714 | -0.013 | -3 | 0.474 |
PTK2B |
0.714 | -0.106 | -1 | 0.757 |
FLT4 |
0.714 | -0.202 | 3 | 0.656 |
EPHA8 |
0.712 | -0.091 | -1 | 0.737 |
NTRK2 |
0.712 | -0.251 | 3 | 0.655 |
INSR |
0.712 | -0.210 | 3 | 0.625 |
DDR2 |
0.712 | -0.154 | 3 | 0.645 |
NTRK3 |
0.709 | -0.189 | -1 | 0.690 |
FGFR4 |
0.709 | -0.104 | -1 | 0.704 |
CSK |
0.709 | -0.152 | 2 | 0.734 |
PTK2 |
0.705 | -0.074 | -1 | 0.639 |
MUSK |
0.701 | -0.157 | 1 | 0.633 |
ERBB4 |
0.701 | -0.068 | 1 | 0.654 |
IGF1R |
0.699 | -0.167 | 3 | 0.571 |
EPHA2 |
0.699 | -0.124 | -1 | 0.682 |
FES |
0.690 | -0.154 | -1 | 0.658 |
ZAP70 |
0.685 | -0.068 | -1 | 0.588 |