Motif 710 (n=253)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0MZ66 | SHTN1 | S249 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A5A3E0 | POTEF | Y791 | ochoa | POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein) | None |
| C4P0D8 | TSNAX-DISC1 | S33 | ochoa | Disrupted in schizophrenia 1 isoform 51 (TSNAX-DISC1 readthrough (NMD candidate)) | None |
| E9PSI1 | None | S287 | ochoa | Transmembrane 9 superfamily member | Plays an essential role in autophagy. {ECO:0000256|ARBA:ARBA00037688}. |
| H7C0S8 | None | S222 | ochoa | Argininosuccinate lyase (Calcitonin gene-related peptide-receptor component protein) (DNA-directed RNA polymerase III subunit RPC9) | Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. {ECO:0000256|ARBA:ARBA00043924}.; FUNCTION: Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues. Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway. {ECO:0000256|ARBA:ARBA00045522}.; FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. {ECO:0000256|ARBA:ARBA00045808}. |
| H8Y6P7 | GCOM1 | S575 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | None |
| O00592 | PODXL | S529 | ochoa | Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) | Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}. |
| O14654 | IRS4 | S1061 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O15321 | TM9SF1 | S78 | ochoa | Transmembrane 9 superfamily member 1 (MP70 protein family member) (hMP70) | Plays an essential role in autophagy. {ECO:0000269|PubMed:19029833}. |
| O43143 | DHX15 | S64 | ochoa | ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43) | RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19103666, PubMed:19432882, PubMed:24782566, PubMed:24990078, PubMed:32179686, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (PubMed:19103666). In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (PubMed:19103666). Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:24782566, PubMed:24990078, PubMed:34161762). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (PubMed:24782566, PubMed:24990078, PubMed:34161762). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:34161762). The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity). {ECO:0000250|UniProtKB:O35286, ECO:0000269|PubMed:19103666, ECO:0000269|PubMed:19432882, ECO:0000269|PubMed:24782566, ECO:0000269|PubMed:24990078, ECO:0000269|PubMed:32179686, ECO:0000269|PubMed:34161762}. |
| O43148 | RNMT | S71 | ochoa | mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}. |
| O43166 | SIPA1L1 | S96 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43491 | EPB41L2 | S647 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43837 | IDH3B | S173 | ochoa | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta) | Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. {ECO:0000269|PubMed:28139779}. |
| O60281 | ZNF292 | S1768 | ochoa | Zinc finger protein 292 | May be involved in transcriptional regulation. |
| O75152 | ZC3H11A | S290 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75376 | NCOR1 | S2380 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75575 | CRCP | S37 | ochoa | DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity) (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:Q9C0Z9, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:34675218}.; FUNCTION: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. {ECO:0000250|UniProtKB:O35427}. |
| O94782 | USP1 | S472 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94868 | FCHSD2 | S530 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O94885 | SASH1 | S387 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94886 | TMEM63A | S98 | ochoa | Mechanosensitive cation channel TMEM63A (Transmembrane protein 63A) (hTMEM63A) | Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:30382938, PubMed:31587869, PubMed:37543036). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (By similarity). Important for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (By similarity). {ECO:0000250|UniProtKB:Q91YT8, ECO:0000269|PubMed:30382938, ECO:0000269|PubMed:31587869, ECO:0000269|PubMed:37543036, ECO:0000269|PubMed:38127458, ECO:0000269|PubMed:39716028}. |
| O94986 | CEP152 | S130 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95067 | CCNB2 | S22 | ochoa | G2/mitotic-specific cyclin-B2 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
| O95359 | TACC2 | S2534 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95376 | ARIH2 | S353 | ochoa | E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (Triad1 protein) | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655, PubMed:33268465, PubMed:34518685, PubMed:38418882). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (PubMed:33268465, PubMed:34518685, PubMed:38418882). The initial ubiquitin is then elongated (PubMed:33268465). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the cullin-5 (CUL5) component of the ECS complex (PubMed:24076655). Together with the ECS(ASB9) complex, catalyzes ubiquitination of CKB (PubMed:33268465). Promotes ubiquitination of DCUN1D1 (PubMed:30587576). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). {ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:30587576, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:34518685, ECO:0000269|PubMed:38418882}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, acts together with a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, to catalyze ubiquitination and degradation of APOBEC3F and APOBEC3G. {ECO:0000269|PubMed:31253590, ECO:0000269|PubMed:36754086}. |
| O95801 | TTC4 | S243 | ochoa | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. |
| P01111 | NRAS | S39 | ochoa | GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras) | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. {ECO:0000269|PubMed:30712867}. |
| P01112 | HRAS | S39 | ochoa | GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed] | Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). {ECO:0000269|PubMed:12740440, ECO:0000269|PubMed:14500341, ECO:0000269|PubMed:22821884, ECO:0000269|PubMed:9020151}. |
| P01116 | KRAS | S39 | ochoa | GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed] | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Plays an important role in the regulation of cell proliferation (PubMed:22711838, PubMed:23698361). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). {ECO:0000269|PubMed:20949621, ECO:0000269|PubMed:22711838, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:39809765}. |
| P02652 | APOA2 | S35 | ochoa | Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))] | May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. |
| P04844 | RPN2 | S516 | ochoa | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2) | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. {ECO:0000250|UniProtKB:F1PCT7, ECO:0000269|PubMed:31831667}. |
| P05181 | CYP2E1 | S256 | psp | Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}. |
| P05546 | SERPIND1 | S37 | ochoa | Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1) | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. {ECO:0000269|PubMed:1939083, ECO:0000269|PubMed:32827448}.; FUNCTION: Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. {ECO:0000269|PubMed:1939083}.; FUNCTION: [Isoform 2]: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro. {ECO:0000269|PubMed:32827448}. |
| P06576 | ATP5F1B | S106 | ochoa | ATP synthase F(1) complex subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) | Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:25168243, ECO:0000305|PubMed:36239646, ECO:0000305|PubMed:37244256}. |
| P07195 | LDHB | S238 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P08670 | VIM | S205 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P08684 | CYP3A4 | S478 | psp | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P0CAP2 | POLR2M | S178 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | [Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904, ECO:0000269|PubMed:30190596}. |
| P0CG38 | POTEI | Y791 | ochoa | POTE ankyrin domain family member I | None |
| P0CG39 | POTEJ | Y754 | ochoa | POTE ankyrin domain family member J | None |
| P0DPH7 | TUBA3C | S287 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S287 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P12277 | CKB | S163 | ochoa | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| P12956 | XRCC6 | S180 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P15498 | VAV1 | S215 | ochoa | Proto-oncogene vav | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| P17661 | DES | S290 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P18583 | SON | S1646 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19367 | HK1 | S124 | psp | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) | Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}. |
| P22460 | KCNA5 | S592 | psp | Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:12130714, PubMed:8505626). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). May play a role in regulating the secretion of insulin in normal pancreatic islets. {ECO:0000250|UniProtKB:Q61762, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:17267549, ECO:0000269|PubMed:20018952, ECO:0000269|PubMed:36917789, ECO:0000269|PubMed:8505626}.; FUNCTION: [Isoform 2]: Exhibits a faster depolarization rate, reduced voltage-dependent recovery from inactivation and an excessive cumulative inactivation. {ECO:0000269|PubMed:11524461}. |
| P26640 | VARS1 | S502 | ochoa | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}. |
| P27348 | YWHAQ | S92 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P30679 | GNA15 | S336 | psp | Guanine nucleotide-binding protein subunit alpha-15 (G alpha-15) (G-protein subunit alpha-15) (Epididymis tissue protein Li 17E) (Guanine nucleotide-binding protein subunit alpha-16) (G alpha-16) (G-protein subunit alpha-16) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. |
| P33241 | LSP1 | S218 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P36871 | PGM1 | S477 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P36952 | SERPINB5 | S135 | ochoa | Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5) | Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| P38646 | HSPA9 | S639 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P39748 | FEN1 | S293 | ochoa | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
| P40227 | CCT6A | S246 | ochoa | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P43243 | MATR3 | S501 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P48382 | RFX5 | S312 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
| P48681 | NES | S47 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49916 | LIG3 | S472 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P52209 | PGD | S291 | ochoa | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}. |
| P55081 | MFAP1 | S361 | ochoa | Microfibrillar-associated protein 1 (Spliceosome B complex protein MFAP1) | Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}. |
| P60709 | ACTB | Y91 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62495 | ETF1 | S123 | ochoa | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793, PubMed:7990965). The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:26245381, PubMed:27863242, PubMed:36638793). ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:26245381, PubMed:27863242, PubMed:36638793). Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:10676813, PubMed:16777602, PubMed:26245381, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:10676813, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:26245381, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:7990965}. |
| P62854 | RPS26 | S54 | ochoa | Small ribosomal subunit protein eS26 (40S ribosomal protein S26) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688}. |
| P63261 | ACTG1 | Y91 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P68032 | ACTC1 | Y93 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | Y93 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68363 | TUBA1B | S287 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S287 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P68431 | H3C1 | S58 | ochoa | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P78362 | SRPK2 | S312 | ochoa | SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. |
| P78527 | PRKDC | S2998 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P84243 | H3-3A | S58 | ochoa | Histone H3.3 | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| Q00653 | NFKB2 | S427 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q01201 | RELB | S151 | ochoa | Transcription factor RelB (I-Rel) | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}. |
| Q01780 | EXOSC10 | S593 | ochoa | Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2) | Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (PubMed:25632158, PubMed:31086179). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (PubMed:31086179). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (PubMed:26857222, PubMed:36912080). Required for cell proliferation (PubMed:36912080). Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins (PubMed:32830871). {ECO:0000250|UniProtKB:P56960, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273, ECO:0000269|PubMed:25632158, ECO:0000269|PubMed:26857222, ECO:0000269|PubMed:31086179, ECO:0000269|PubMed:32830871, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:36912080}. |
| Q01831 | XPC | S903 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q02487 | DSC2 | S868 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
| Q02952 | AKAP12 | S386 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q06546 | GABPA | S26 | ochoa | GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) | Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). {ECO:0000269|PubMed:22306510}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene. |
| Q07157 | TJP1 | S810 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07157 | TJP1 | S1142 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q09666 | AHNAK | S176 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5604 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13309 | SKP2 | S57 | ochoa | S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:9736735, PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1 (By similarity). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:9736735, PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731). {ECO:0000250|UniProtKB:Q9Z0Z3, ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|PubMed:16262255, ECO:0000269|PubMed:16581786, ECO:0000269|PubMed:16951159, ECO:0000269|PubMed:17908926, ECO:0000269|PubMed:17962192, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:22770219, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:9736735}.; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. {ECO:0000269|PubMed:27194766}. |
| Q13323 | BIK | S124 | psp | Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4) | Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. {ECO:0000269|PubMed:8521816}. |
| Q13393 | PLD1 | S499 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q13415 | ORC1 | S340 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13416 | ORC2 | S249 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13477 | MADCAM1 | S358 | ochoa | Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1) | Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. |
| Q13546 | RIPK1 | S291 | psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q14596 | NBR1 | S276 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q14671 | PUM1 | S124 | ochoa | Pumilio homolog 1 (HsPUM) (Pumilio-1) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}. |
| Q14680 | MELK | S407 | psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q14684 | RRP1B | S160 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14966 | ZNF638 | S1667 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15047 | SETDB1 | S872 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15361 | TTF1 | S253 | ochoa | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}. |
| Q15361 | TTF1 | S478 | ochoa | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}. |
| Q15545 | TAF7 | S201 | ochoa | Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}. |
| Q16625 | OCLN | S40 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q16695 | H3-4 | S58 | ochoa | Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q2M2I8 | AAK1 | S652 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q4G0A6 | MINDY4 | S396 | ochoa | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (EC 3.4.19.12) (Probable deubiquitinating enzyme MINDY-4) | Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000250|UniProtKB:Q8NBR6}. |
| Q562F6 | SGO2 | S1165 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5JRA6 | MIA3 | S1539 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5QJE6 | DNTTIP2 | S429 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5R372 | RABGAP1L | S292 | ochoa | Rab GTPase-activating protein 1-like | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}. |
| Q5SQS7 | SH2D4B | S361 | ochoa | SH2 domain-containing protein 4B | None |
| Q5T7W7 | TSTD2 | S269 | ochoa | Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (Rhodanese domain-containing protein 2) | None |
| Q5T8P6 | RBM26 | S589 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5TEC6 | H3-7 | S58 | ochoa | Histone H3-7 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000250|UniProtKB:P68431}. |
| Q5UIP0 | RIF1 | S978 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1971 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VZL5 | ZMYM4 | S1064 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q69YH5 | CDCA2 | S666 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6NXT2 | H3-5 | S57 | ochoa | Histone H3.3C (Histone H3.5) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. {ECO:0000269|PubMed:21274551}. |
| Q6P3S1 | DENND1B | S562 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
| Q6PEY2 | TUBA3E | S287 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6PHR2 | ULK3 | S305 | ochoa | Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}. |
| Q6R327 | RICTOR | S1144 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6S8J3 | POTEE | Y791 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q6VMQ6 | ATF7IP | S429 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q71DI3 | H3C15 | S58 | ochoa | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q71U36 | TUBA1A | S287 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7L8J4 | SH3BP5L | S43 | ochoa | SH3 domain-binding protein 5-like (SH3BP-5-like) | Functions as a guanine nucleotide exchange factor (GEF) for RAB11A. {ECO:0000269|PubMed:30217979}. |
| Q7Z3K6 | MIER3 | S114 | ochoa | Mesoderm induction early response protein 3 (Mi-er3) | Transcriptional repressor. {ECO:0000250}. |
| Q7Z3T8 | ZFYVE16 | S330 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z6B7 | SRGAP1 | S407 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q7Z6Z7 | HUWE1 | S2963 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z6Z7 | HUWE1 | S3258 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86TC9 | MYPN | S391 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86UP2 | KTN1 | S1244 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86UP2 | KTN1 | S1325 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86UW6 | N4BP2 | S132 | psp | NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) | Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}. |
| Q8IVF2 | AHNAK2 | S753 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4046 | ochoa | Protein AHNAK2 | None |
| Q8IVT2 | MISP | S376 | ochoa|psp | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWZ3 | ANKHD1 | S105 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IXT5 | RBM12B | S387 | ochoa | RNA-binding protein 12B (RNA-binding motif protein 12B) | None |
| Q8N3K9 | CMYA5 | S1981 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N5A5 | ZGPAT | S53 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8N5U6 | RNF10 | S487 | ochoa | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). {ECO:0000250|UniProtKB:Q5XI59, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}. |
| Q8N680 | ZBTB2 | S488 | ochoa | Zinc finger and BTB domain-containing protein 2 | May be involved in transcriptional regulation. |
| Q8NCE0 | TSEN2 | S215 | ochoa | tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity. {ECO:0000269|PubMed:15109492}. |
| Q8NCN4 | RNF169 | S521 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NEZ4 | KMT2C | S1493 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NF91 | SYNE1 | S8665 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NFC6 | BOD1L1 | S983 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFQ8 | TOR1AIP2 | S168 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8NFW9 | MYRIP | S335 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Q8NI35 | PATJ | S522 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8TC76 | FAM110B | S199 | ochoa | Protein FAM110B | May be involved in tumor progression. |
| Q8TCU6 | PREX1 | S1272 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TDY2 | RB1CC1 | S1221 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q92526 | CCT6B | S246 | ochoa | T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (CCT-zeta-like) (Chaperonin containing T-complex polypeptide 1 subunit 6B) (TCP-1-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. {ECO:0000305|PubMed:8812458}. |
| Q92540 | SMG7 | S510 | ochoa | Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7) | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}. |
| Q92575 | UBXN4 | S458 | ochoa | UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) | Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). {ECO:0000269|PubMed:16968747, ECO:0000269|PubMed:19822669}. |
| Q92667 | AKAP1 | S69 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92917 | GPKOW | S115 | ochoa | G-patch domain and KOW motifs-containing protein (G-patch domain-containing protein 5) (Protein MOS2 homolog) (Protein T54) | RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:25296192, ECO:0000305|PubMed:33509932}. |
| Q92932 | PTPRN2 | S776 | ochoa | Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] | Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}. |
| Q93074 | MED12 | S557 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
| Q96BX8 | MOB3A | S38 | psp | MOB kinase activator 3A (MOB-LAK) (Mob1 homolog 2A) (Mps one binder kinase activator-like 2A) | May regulate the activity of kinases. {ECO:0000250}. |
| Q96F05 | C11orf24 | S61 | ochoa | Uncharacterized protein C11orf24 (Protein DM4E3) | None |
| Q96GN5 | CDCA7L | S320 | ochoa | Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2) | Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933, ECO:0000269|PubMed:16829576}. |
| Q96L73 | NSD1 | S1269 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96N46 | TTC14 | S733 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96T37 | RBM15 | S935 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99569 | PKP4 | S127 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99598 | TSNAX | S33 | ochoa | Translin-associated protein X (Translin-associated factor X) | Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. {ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:21552258}. |
| Q9BPZ7 | MAPKAP1 | S260 | ochoa|psp | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BQ39 | DDX50 | S113 | ochoa | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q9BRF8 | CPPED1 | S294 | ochoa | Serine/threonine-protein phosphatase CPPED1 (EC 3.1.3.16) (Calcineurin-like phosphoesterase domain-containing protein 1) (Complete S-transactivated protein 1) | Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. {ECO:0000269|PubMed:23799035, ECO:0000269|PubMed:23939394}. |
| Q9BTC0 | DIDO1 | S1205 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BVV6 | KIAA0586 | S376 | ochoa | Protein TALPID3 | Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9, ECO:0000269|PubMed:24421332}. |
| Q9BWF3 | RBM4 | S331 | ochoa | RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) | RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:37548402}. |
| Q9BYX7 | POTEKP | Y91 | ochoa | Putative beta-actin-like protein 3 (Kappa-actin) (POTE ankyrin domain family member K) | None |
| Q9GZP1 | NRSN2 | S157 | ochoa | Neurensin-2 | May play a role in maintenance and/or transport of vesicles. |
| Q9H0G5 | NSRP1 | S446 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
| Q9H2G2 | SLK | S518 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2G2 | SLK | S571 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H6T3 | RPAP3 | S121 | ochoa|psp | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H9E3 | COG4 | S26 | ochoa | Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) | Required for normal Golgi function (PubMed:19536132, PubMed:30290151). Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132). {ECO:0000269|PubMed:19536132, ECO:0000269|PubMed:30290151}. |
| Q9HB90 | RRAGC | S376 | ochoa | Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:31601708, PubMed:31601764, PubMed:32612235, PubMed:34071043, PubMed:36697823, PubMed:37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279, PubMed:31601708, PubMed:31601764, PubMed:32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:32612235, PubMed:36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279, PubMed:27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235, PubMed:36697823). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27234373, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:34071043, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37057673}. |
| Q9HCE5 | METTL14 | S54 | ochoa | N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (Methyltransferase-like protein 14) (hMETTL14) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:27281194, PubMed:27373337, PubMed:29348140). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q3UIK4, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:29348140}. |
| Q9HCH5 | SYTL2 | S583 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NUU7 | DDX19A | S85 | ochoa | ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DDX19-like protein) (DEAD box protein 19A) | ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. {ECO:0000250|UniProtKB:Q9UMR2}. |
| Q9NY65 | TUBA8 | S287 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9NYB0 | TERF2IP | S105 | ochoa | Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}. |
| Q9NYD6 | HOXC10 | S115 | ochoa | Homeobox protein Hox-C10 (Homeobox protein Hox-3I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Q9NYH9 | UTP6 | S204 | ochoa | U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}. |
| Q9NYV4 | CDK12 | S1201 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZU0 | FLRT3 | S585 | ochoa | Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3) | Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity). {ECO:0000250|UniProtKB:B1H234, ECO:0000250|UniProtKB:Q8BGT1, ECO:0000269|PubMed:14706654, ECO:0000269|PubMed:26235030}. |
| Q9NZZ3 | CHMP5 | S98 | ochoa | Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60) | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) (PubMed:14519844). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release (PubMed:14519844). {ECO:0000269|PubMed:14519844}. |
| Q9P246 | STIM2 | S344 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P2N5 | RBM27 | S657 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9UBB9 | TFIP11 | S283 | ochoa | Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1) | Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}. |
| Q9UBY0 | SLC9A2 | S596 | ochoa | Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity). {ECO:0000250|UniProtKB:Q3ZAS0, ECO:0000269|PubMed:10444453}. |
| Q9UEW8 | STK39 | S309 | psp | STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}. |
| Q9UHB6 | LIMA1 | S184 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UIF9 | BAZ2A | S1155 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UIV8 | SERPINB13 | S150 | ochoa | Serpin B13 (HaCaT UV-repressible serpin) (Hurpin) (Headpin) (Peptidase inhibitor 13) (PI-13) (Proteinase inhibitor 13) | May play a role in the proliferation or differentiation of keratinocytes. |
| Q9UJX4 | ANAPC5 | S179 | ochoa | Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9UK58 | CCNL1 | S69 | ochoa | Cyclin-L1 (Cyclin-L) | Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018}. |
| Q9UKL3 | CASP8AP2 | S1368 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKW4 | VAV3 | S213 | ochoa | Guanine nucleotide exchange factor VAV3 (VAV-3) | Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). {ECO:0000250}. |
| Q9ULD4 | BRPF3 | S886 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9ULF5 | SLC39A10 | S608 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9ULJ3 | ZBTB21 | S516 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9UM54 | MYO6 | S1019 | ochoa | Unconventional myosin-VI (Unconventional myosin-6) | Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:29467281, ECO:0000269|PubMed:31371777}. |
| Q9UMR2 | DDX19B | S86 | ochoa | ATP-dependent RNA helicase DDX19B (EC 3.6.4.13) (DEAD box RNA helicase DEAD5) (DEAD box protein 19B) | ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). {ECO:0000269|PubMed:10428971}. |
| Q9UPM8 | AP4E1 | S850 | ochoa | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9UPN4 | CEP131 | S534 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9Y294 | ASF1A | S166 | ochoa|psp | Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485, ECO:0000269|PubMed:29478807}. |
| Q9Y2L5 | TRAPPC8 | S311 | ochoa | Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) | Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Involved in collagen secretion (PubMed:32095531). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:26711178, ECO:0000269|PubMed:32095531}. |
| Q9Y2X9 | ZNF281 | S784 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y2Y0 | ARL2BP | S141 | ochoa | ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) (ARL2-binding protein) (Binder of ARF2 protein 1) | Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. {ECO:0000269|PubMed:18234692}. |
| Q9Y3Z3 | SAMHD1 | S519 | ochoa | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) | Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23364794, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:25038827, PubMed:26101257, PubMed:26294762, PubMed:26431200, PubMed:28229507). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:24217394, PubMed:29610582). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23601106, PubMed:23602554, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). {ECO:0000250|UniProtKB:Q60710, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:21613998, ECO:0000269|PubMed:21720370, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:23364794, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198, ECO:0000269|PubMed:25038827, ECO:0000269|PubMed:26101257, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:27477283, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28834754, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289}. |
| Q9Y4B5 | MTCL1 | S1412 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y5K8 | ATP6V1D | S118 | ochoa | V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (PubMed:21844891). {ECO:0000250|UniProtKB:P39942, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:33065002}. |
| U3KPZ7 | LOC127814297 | S602 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
| P14314 | PRKCSH | S126 | Sugiyama | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| Q9Y265 | RUVBL1 | S434 | Sugiyama | RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). Essential for cell proliferation (PubMed:14506706). May be able to bind plasminogen at cell surface and enhance plasminogen activation (PubMed:11027681). {ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11027681, ECO:0000269|PubMed:14506706, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:33205750}. |
| P25205 | MCM3 | S34 | Sugiyama | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P28838 | LAP3 | S54 | Sugiyama | Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) | Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250|UniProtKB:P00727}. |
| P61769 | B2M | S72 | Sugiyama | Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}. |
| P07947 | YES1 | S133 | Sugiyama | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| Q96DB5 | RMDN1 | Y92 | Sugiyama | Regulator of microtubule dynamics protein 1 (RMD-1) (hRMD-1) (Protein FAM82B) | None |
| P53634 | CTSC | S343 | Sugiyama | Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] | Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921). {ECO:0000269|PubMed:1586157, ECO:0000269|PubMed:8428921}. |
| Q14152 | EIF3A | Y427 | Sugiyama | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q5H9R7 | PPP6R3 | S502 | Sugiyama | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| P35580 | MYH10 | S1371 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P35579 | MYH9 | S96 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35580 | MYH10 | S100 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P59047 | NLRP5 | S331 | SIGNOR | NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog) (Maternal Antigen that Embryos Require) | Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation. {ECO:0000250|UniProtKB:Q9R1M5}. |
| O60828 | PQBP1 | S208 | Sugiyama | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:21933836, ECO:0000269|PubMed:23512658, ECO:0000269|PubMed:26046437}. |
| Q13554 | CAMK2B | S26 | Sugiyama | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| P51812 | RPS6KA3 | S66 | Sugiyama | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| Q15349 | RPS6KA2 | S57 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| P55084 | HADHB | S248 | Sugiyama | Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] | Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:29915090, PubMed:30850536, PubMed:8135828). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity (PubMed:29915090, PubMed:30850536, PubMed:8135828). {ECO:0000269|PubMed:29915090, ECO:0000269|PubMed:30850536, ECO:0000269|PubMed:8135828, ECO:0000303|PubMed:29915090, ECO:0000303|PubMed:30850536}. |
| Q86V86 | PIM3 | S182 | Sugiyama | Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) | Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021, ECO:0000269|PubMed:17876606, ECO:0000269|PubMed:18593906}. |
| P42704 | LRPPRC | S1027 | Sugiyama | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P13489 | RNH1 | S50 | Sugiyama | Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625). {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889, ECO:0000269|PubMed:23843625, ECO:0000269|PubMed:3219362, ECO:0000269|PubMed:3243277, ECO:0000269|PubMed:32510170, ECO:0000269|PubMed:3470787, ECO:0000269|PubMed:9050852}. |
| Q99848 | EBNA1BP2 | S107 | Sugiyama | Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) | Required for the processing of the 27S pre-rRNA. {ECO:0000250}. |
| Q13617 | CUL2 | S230 | Sugiyama | Cullin-2 (CUL-2) | Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:11384984, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:38326650). CUL2 serves as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the E2 ubiquitin-conjugating enzyme (PubMed:10973499, PubMed:11384984, PubMed:12609982, PubMed:24076655, PubMed:9122164, PubMed:38326650). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (PubMed:12609982, PubMed:24076655, PubMed:27565346, PubMed:38326650). The functional specificity of the ECS complex depends on the substrate recognition component (PubMed:10973499, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:9122164, PubMed:38326650). ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (PubMed:10973499, PubMed:9122164). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29775578, PubMed:29779948). ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). {ECO:0000250|UniProtKB:Q9D4H8, ECO:0000269|PubMed:10973499, ECO:0000269|PubMed:11384984, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:9122164}. |
| Q14566 | MCM6 | S341 | Sugiyama | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q9BYP7 | WNK3 | S425 | Sugiyama | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
| O95302 | FKBP9 | S277 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP9 (PPIase FKBP9) (EC 5.2.1.8) (63 kDa FK506-binding protein) (63 kDa FKBP) (FKBP-63) (FK506-binding protein 9) (FKBP-9) (Rotamase) | PPIases accelerate the folding of proteins during protein synthesis. |
| Q5SSJ5 | HP1BP3 | S323 | Sugiyama | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-437239 | Recycling pathway of L1 | 3.512339e-10 | 9.454 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.411421e-09 | 8.850 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.037691e-09 | 8.691 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.881254e-09 | 8.411 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.713689e-09 | 8.173 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.543555e-08 | 7.811 |
| R-HSA-190828 | Gap junction trafficking | 3.389791e-08 | 7.470 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.513047e-07 | 6.820 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.444975e-07 | 6.840 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.943904e-07 | 6.711 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.233860e-07 | 6.651 |
| R-HSA-391251 | Protein folding | 2.861095e-07 | 6.543 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.384700e-07 | 6.470 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 9.025295e-07 | 6.045 |
| R-HSA-1640170 | Cell Cycle | 1.372567e-06 | 5.862 |
| R-HSA-9646399 | Aggrephagy | 1.985285e-06 | 5.702 |
| R-HSA-69306 | DNA Replication | 2.118095e-06 | 5.674 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.555495e-06 | 5.593 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.690582e-06 | 5.570 |
| R-HSA-373760 | L1CAM interactions | 3.448089e-06 | 5.462 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.394262e-06 | 5.357 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 4.516925e-06 | 5.345 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.439248e-06 | 5.264 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.439248e-06 | 5.264 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.439248e-06 | 5.264 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.439248e-06 | 5.264 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 6.209459e-06 | 5.207 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.207484e-06 | 5.207 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 6.209459e-06 | 5.207 |
| R-HSA-422475 | Axon guidance | 6.508155e-06 | 5.187 |
| R-HSA-190861 | Gap junction assembly | 8.560302e-06 | 5.068 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.219268e-05 | 4.914 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 1.293673e-05 | 4.888 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.472269e-05 | 4.832 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.508538e-05 | 4.821 |
| R-HSA-9675108 | Nervous system development | 1.923246e-05 | 4.716 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 2.044522e-05 | 4.689 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.331492e-05 | 4.632 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.256548e-05 | 4.647 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.654785e-05 | 4.576 |
| R-HSA-112412 | SOS-mediated signalling | 3.074554e-05 | 4.512 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.896222e-05 | 4.409 |
| R-HSA-2424491 | DAP12 signaling | 4.335837e-05 | 4.363 |
| R-HSA-1169092 | Activation of RAS in B cells | 4.441363e-05 | 4.352 |
| R-HSA-9753510 | Signaling by RAS GAP mutants | 5.049494e-05 | 4.297 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.553843e-05 | 4.255 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.639155e-05 | 4.249 |
| R-HSA-9663891 | Selective autophagy | 5.553843e-05 | 4.255 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 6.206362e-05 | 4.207 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 8.434420e-05 | 4.074 |
| R-HSA-68949 | Orc1 removal from chromatin | 9.346113e-05 | 4.029 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 9.386811e-05 | 4.027 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 9.498667e-05 | 4.022 |
| R-HSA-1632852 | Macroautophagy | 1.097424e-04 | 3.960 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 1.119352e-04 | 3.951 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.169972e-04 | 3.932 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.259342e-04 | 3.900 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.289934e-04 | 3.889 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.383940e-04 | 3.859 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.383940e-04 | 3.859 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 1.455445e-04 | 3.837 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.592683e-04 | 3.798 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.859044e-04 | 3.731 |
| R-HSA-8851805 | MET activates RAS signaling | 1.859044e-04 | 3.731 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 1.859044e-04 | 3.731 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 1.859044e-04 | 3.731 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.859044e-04 | 3.731 |
| R-HSA-194138 | Signaling by VEGF | 1.828862e-04 | 3.738 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.644753e-04 | 3.784 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.900559e-04 | 3.721 |
| R-HSA-983189 | Kinesins | 1.999846e-04 | 3.699 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.291958e-04 | 3.640 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.379161e-04 | 3.624 |
| R-HSA-69239 | Synthesis of DNA | 2.528077e-04 | 3.597 |
| R-HSA-9612973 | Autophagy | 2.498034e-04 | 3.602 |
| R-HSA-69275 | G2/M Transition | 2.646136e-04 | 3.577 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.057767e-04 | 3.515 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.832274e-04 | 3.548 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.885471e-04 | 3.540 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 2.899130e-04 | 3.538 |
| R-HSA-2172127 | DAP12 interactions | 3.137467e-04 | 3.503 |
| R-HSA-171007 | p38MAPK events | 3.551246e-04 | 3.450 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 3.551246e-04 | 3.450 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 3.551246e-04 | 3.450 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 3.551246e-04 | 3.450 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.832889e-04 | 3.416 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.882245e-04 | 3.411 |
| R-HSA-1280218 | Adaptive Immune System | 3.974380e-04 | 3.401 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.351989e-04 | 3.361 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.875667e-04 | 3.312 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 5.159772e-04 | 3.287 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 5.159772e-04 | 3.287 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.219760e-04 | 3.206 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 5.957786e-04 | 3.225 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 6.132568e-04 | 3.212 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 6.132568e-04 | 3.212 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 6.229895e-04 | 3.206 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 6.229895e-04 | 3.206 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.894621e-04 | 3.161 |
| R-HSA-68886 | M Phase | 6.931762e-04 | 3.159 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 7.228772e-04 | 3.141 |
| R-HSA-210993 | Tie2 Signaling | 7.228772e-04 | 3.141 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 7.781751e-04 | 3.109 |
| R-HSA-5673000 | RAF activation | 7.781751e-04 | 3.109 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.120072e-04 | 3.040 |
| R-HSA-69481 | G2/M Checkpoints | 8.846618e-04 | 3.053 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 8.657816e-04 | 3.063 |
| R-HSA-9833482 | PKR-mediated signaling | 9.117460e-04 | 3.040 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.944948e-04 | 3.002 |
| R-HSA-167044 | Signalling to RAS | 1.134151e-03 | 2.945 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 1.134151e-03 | 2.945 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.134151e-03 | 2.945 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.134151e-03 | 2.945 |
| R-HSA-190873 | Gap junction degradation | 1.232313e-03 | 2.909 |
| R-HSA-9648002 | RAS processing | 1.291192e-03 | 2.889 |
| R-HSA-1500620 | Meiosis | 1.249497e-03 | 2.903 |
| R-HSA-176974 | Unwinding of DNA | 1.232313e-03 | 2.909 |
| R-HSA-68877 | Mitotic Prometaphase | 1.247144e-03 | 2.904 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.300143e-03 | 2.886 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 1.301509e-03 | 2.886 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 1.301509e-03 | 2.886 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 1.301509e-03 | 2.886 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 1.301509e-03 | 2.886 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.354973e-03 | 2.868 |
| R-HSA-199991 | Membrane Trafficking | 1.369075e-03 | 2.864 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 1.485395e-03 | 2.828 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.547183e-03 | 2.810 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.724192e-03 | 2.763 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 1.906078e-03 | 2.720 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.906078e-03 | 2.720 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 1.906078e-03 | 2.720 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.996380e-03 | 2.700 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.996380e-03 | 2.700 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.097012e-03 | 2.678 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 2.144521e-03 | 2.669 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.144521e-03 | 2.669 |
| R-HSA-112316 | Neuronal System | 2.196808e-03 | 2.658 |
| R-HSA-69242 | S Phase | 2.539075e-03 | 2.595 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 2.681667e-03 | 2.572 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.402783e-03 | 2.619 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.402783e-03 | 2.619 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.681667e-03 | 2.572 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 2.681667e-03 | 2.572 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.729331e-03 | 2.564 |
| R-HSA-68882 | Mitotic Anaphase | 2.843528e-03 | 2.546 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.935175e-03 | 2.532 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 2.981966e-03 | 2.525 |
| R-HSA-5620924 | Intraflagellar transport | 3.008962e-03 | 2.522 |
| R-HSA-69206 | G1/S Transition | 3.171693e-03 | 2.499 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.256093e-03 | 2.487 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 3.304460e-03 | 2.481 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.304460e-03 | 2.481 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.489008e-03 | 2.457 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.649916e-03 | 2.438 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.649916e-03 | 2.438 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.649916e-03 | 2.438 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.871834e-03 | 2.412 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.019091e-03 | 2.396 |
| R-HSA-186763 | Downstream signal transduction | 4.019091e-03 | 2.396 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 4.923388e-03 | 2.308 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.892226e-03 | 2.310 |
| R-HSA-9609690 | HCMV Early Events | 4.413727e-03 | 2.355 |
| R-HSA-69190 | DNA strand elongation | 4.412723e-03 | 2.355 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.413727e-03 | 2.355 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.402500e-03 | 2.356 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.937842e-03 | 2.306 |
| R-HSA-5654736 | Signaling by FGFR1 | 5.257515e-03 | 2.279 |
| R-HSA-390522 | Striated Muscle Contraction | 5.276249e-03 | 2.278 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.604150e-03 | 2.251 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.767278e-03 | 2.239 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.966609e-03 | 2.224 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 6.246105e-03 | 2.204 |
| R-HSA-187687 | Signalling to ERKs | 6.246105e-03 | 2.204 |
| R-HSA-109582 | Hemostasis | 6.492792e-03 | 2.188 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.740471e-03 | 2.171 |
| R-HSA-9682385 | FLT3 signaling in disease | 6.772586e-03 | 2.169 |
| R-HSA-2262752 | Cellular responses to stress | 7.042683e-03 | 2.152 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 7.152602e-03 | 2.146 |
| R-HSA-4839726 | Chromatin organization | 7.371984e-03 | 2.132 |
| R-HSA-421270 | Cell-cell junction organization | 7.765750e-03 | 2.110 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.958886e-03 | 2.099 |
| R-HSA-2559583 | Cellular Senescence | 8.031341e-03 | 2.095 |
| R-HSA-2428924 | IGF1R signaling cascade | 8.494072e-03 | 2.071 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 8.558231e-03 | 2.068 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.071077e-02 | 1.970 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 9.170250e-03 | 2.038 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 9.479429e-03 | 2.023 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.055236e-02 | 1.977 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 9.845567e-03 | 2.007 |
| R-HSA-199920 | CREB phosphorylation | 1.071077e-02 | 1.970 |
| R-HSA-69620 | Cell Cycle Checkpoints | 9.274377e-03 | 2.033 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 8.977418e-03 | 2.047 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.045070e-02 | 1.981 |
| R-HSA-418990 | Adherens junctions interactions | 8.707868e-03 | 2.060 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.055236e-02 | 1.977 |
| R-HSA-9607240 | FLT3 Signaling | 9.845567e-03 | 2.007 |
| R-HSA-5617833 | Cilium Assembly | 1.080140e-02 | 1.967 |
| R-HSA-157579 | Telomere Maintenance | 1.146922e-02 | 1.940 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.168072e-02 | 1.933 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.168072e-02 | 1.933 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.168072e-02 | 1.933 |
| R-HSA-5654743 | Signaling by FGFR4 | 1.206246e-02 | 1.919 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.228095e-02 | 1.911 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.228095e-02 | 1.911 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.286674e-02 | 1.891 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.296630e-02 | 1.887 |
| R-HSA-5654741 | Signaling by FGFR3 | 1.370448e-02 | 1.863 |
| R-HSA-1474165 | Reproduction | 1.381216e-02 | 1.860 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.403733e-02 | 1.853 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.420636e-02 | 1.848 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.457610e-02 | 1.836 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.476929e-02 | 1.831 |
| R-HSA-446728 | Cell junction organization | 1.484679e-02 | 1.828 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.548203e-02 | 1.810 |
| R-HSA-444257 | RSK activation | 1.564605e-02 | 1.806 |
| R-HSA-196025 | Formation of annular gap junctions | 1.564605e-02 | 1.806 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 1.564605e-02 | 1.806 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.564605e-02 | 1.806 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.564605e-02 | 1.806 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.639635e-02 | 1.785 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.642267e-02 | 1.785 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.642267e-02 | 1.785 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.670299e-02 | 1.777 |
| R-HSA-168256 | Immune System | 1.739244e-02 | 1.760 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 1.840957e-02 | 1.735 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.864389e-02 | 1.729 |
| R-HSA-9609646 | HCMV Infection | 1.928530e-02 | 1.715 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.933091e-02 | 1.714 |
| R-HSA-912446 | Meiotic recombination | 1.945651e-02 | 1.711 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.946263e-02 | 1.711 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.972060e-02 | 1.705 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.972060e-02 | 1.705 |
| R-HSA-5334118 | DNA methylation | 2.295380e-02 | 1.639 |
| R-HSA-171319 | Telomere Extension By Telomerase | 2.130339e-02 | 1.672 |
| R-HSA-1221632 | Meiotic synapsis | 2.165898e-02 | 1.664 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.165898e-02 | 1.664 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.205933e-02 | 1.656 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 2.104519e-02 | 1.677 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.191883e-02 | 1.659 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.648025e-02 | 1.577 |
| R-HSA-913531 | Interferon Signaling | 2.347616e-02 | 1.629 |
| R-HSA-177929 | Signaling by EGFR | 2.523823e-02 | 1.598 |
| R-HSA-112399 | IRS-mediated signalling | 2.650573e-02 | 1.577 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.656289e-02 | 1.576 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 2.782615e-02 | 1.556 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.831043e-02 | 1.548 |
| R-HSA-180786 | Extension of Telomeres | 2.915357e-02 | 1.535 |
| R-HSA-73886 | Chromosome Maintenance | 3.011040e-02 | 1.521 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.017545e-02 | 1.520 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.017545e-02 | 1.520 |
| R-HSA-9930044 | Nuclear RNA decay | 3.023067e-02 | 1.520 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.053422e-02 | 1.515 |
| R-HSA-1500931 | Cell-Cell communication | 3.190069e-02 | 1.496 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.221790e-02 | 1.492 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.221790e-02 | 1.492 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.229850e-02 | 1.491 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.340965e-02 | 1.476 |
| R-HSA-186797 | Signaling by PDGF | 3.340965e-02 | 1.476 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.427181e-02 | 1.465 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.490463e-02 | 1.457 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.490463e-02 | 1.457 |
| R-HSA-8848021 | Signaling by PTK6 | 3.490463e-02 | 1.457 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.490463e-02 | 1.457 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 3.495716e-02 | 1.456 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.496388e-02 | 1.456 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.496388e-02 | 1.456 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.496388e-02 | 1.456 |
| R-HSA-74751 | Insulin receptor signalling cascade | 3.643790e-02 | 1.438 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.671545e-02 | 1.435 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.671545e-02 | 1.435 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.810479e-02 | 1.419 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.857824e-02 | 1.414 |
| R-HSA-9824446 | Viral Infection Pathways | 3.876678e-02 | 1.412 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.961951e-02 | 1.402 |
| R-HSA-1266738 | Developmental Biology | 3.998874e-02 | 1.398 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.082990e-02 | 1.389 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 4.097891e-02 | 1.387 |
| R-HSA-190236 | Signaling by FGFR | 4.097891e-02 | 1.387 |
| R-HSA-3214847 | HATs acetylate histones | 4.232349e-02 | 1.373 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 4.271115e-02 | 1.369 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 4.271115e-02 | 1.369 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 4.271115e-02 | 1.369 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.295471e-02 | 1.367 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.494701e-02 | 1.347 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 4.680611e-02 | 1.330 |
| R-HSA-9708530 | Regulation of BACH1 activity | 4.680611e-02 | 1.330 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.710407e-02 | 1.327 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.797268e-02 | 1.319 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.819163e-02 | 1.317 |
| R-HSA-5619056 | Defective HK1 causes hexokinase deficiency (HK deficiency) | 5.012395e-02 | 1.300 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 5.012395e-02 | 1.300 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 5.540209e-02 | 1.256 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.196361e-02 | 1.284 |
| R-HSA-380287 | Centrosome maturation | 5.583416e-02 | 1.253 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.048097e-02 | 1.297 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 6.394786e-02 | 1.194 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.048097e-02 | 1.297 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.094640e-02 | 1.293 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.094640e-02 | 1.293 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 5.048097e-02 | 1.297 |
| R-HSA-912631 | Regulation of signaling by CBL | 6.450153e-02 | 1.190 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.192321e-02 | 1.208 |
| R-HSA-9664407 | Parasite infection | 5.510377e-02 | 1.259 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.510377e-02 | 1.259 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.510377e-02 | 1.259 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 5.103836e-02 | 1.292 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 5.989165e-02 | 1.223 |
| R-HSA-9710421 | Defective pyroptosis | 5.837888e-02 | 1.234 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.782622e-02 | 1.238 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 6.450153e-02 | 1.190 |
| R-HSA-73894 | DNA Repair | 6.523759e-02 | 1.186 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 6.450153e-02 | 1.190 |
| R-HSA-8953854 | Metabolism of RNA | 6.460740e-02 | 1.190 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.394786e-02 | 1.194 |
| R-HSA-1483148 | Synthesis of PG | 5.103836e-02 | 1.292 |
| R-HSA-162906 | HIV Infection | 6.476842e-02 | 1.189 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 6.922638e-02 | 1.160 |
| R-HSA-198753 | ERK/MAPK targets | 7.406100e-02 | 1.130 |
| R-HSA-156711 | Polo-like kinase mediated events | 5.989165e-02 | 1.223 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 7.406100e-02 | 1.130 |
| R-HSA-977225 | Amyloid fiber formation | 6.834824e-02 | 1.165 |
| R-HSA-75153 | Apoptotic execution phase | 6.682116e-02 | 1.175 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.923798e-02 | 1.160 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.122590e-02 | 1.147 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.616954e-02 | 1.179 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.583416e-02 | 1.253 |
| R-HSA-6806834 | Signaling by MET | 6.616954e-02 | 1.179 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 6.450153e-02 | 1.190 |
| R-HSA-166520 | Signaling by NTRKs | 6.811228e-02 | 1.167 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.387991e-02 | 1.269 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.510387e-02 | 1.124 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 7.510387e-02 | 1.124 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.604786e-02 | 1.119 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.827379e-02 | 1.106 |
| R-HSA-68875 | Mitotic Prophase | 8.253609e-02 | 1.083 |
| R-HSA-162587 | HIV Life Cycle | 8.275874e-02 | 1.082 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.448648e-02 | 1.073 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 8.525148e-02 | 1.069 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.707994e-02 | 1.060 |
| R-HSA-168249 | Innate Immune System | 8.710647e-02 | 1.060 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.713370e-02 | 1.060 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 8.851331e-02 | 1.053 |
| R-HSA-9018682 | Biosynthesis of maresins | 8.917350e-02 | 1.050 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 8.917350e-02 | 1.050 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.992991e-02 | 1.046 |
| R-HSA-109581 | Apoptosis | 9.159593e-02 | 1.038 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 9.211463e-02 | 1.036 |
| R-HSA-73884 | Base Excision Repair | 9.211463e-02 | 1.036 |
| R-HSA-3214815 | HDACs deacetylate histones | 9.519156e-02 | 1.021 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.656867e-02 | 1.015 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 9.774414e-02 | 1.010 |
| R-HSA-191650 | Regulation of gap junction activity | 9.774414e-02 | 1.010 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 9.774414e-02 | 1.010 |
| R-HSA-193648 | NRAGE signals death through JNK | 9.860605e-02 | 1.006 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 9.860605e-02 | 1.006 |
| R-HSA-3214842 | HDMs demethylate histones | 9.970814e-02 | 1.001 |
| R-HSA-1266695 | Interleukin-7 signaling | 9.970814e-02 | 1.001 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 9.970814e-02 | 1.001 |
| R-HSA-70635 | Urea cycle | 1.050998e-01 | 0.978 |
| R-HSA-397014 | Muscle contraction | 1.067144e-01 | 0.972 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 1.105685e-01 | 0.956 |
| R-HSA-8949613 | Cristae formation | 1.105685e-01 | 0.956 |
| R-HSA-171306 | Packaging Of Telomere Ends | 1.105685e-01 | 0.956 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.105685e-01 | 0.956 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 1.105685e-01 | 0.956 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.105685e-01 | 0.956 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.127434e-01 | 0.948 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 1.130829e-01 | 0.947 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 1.130829e-01 | 0.947 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.281618e-01 | 0.892 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 1.281618e-01 | 0.892 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.575575e-01 | 0.803 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.718829e-01 | 0.765 |
| R-HSA-5218900 | CASP8 activity is inhibited | 1.859656e-01 | 0.731 |
| R-HSA-164843 | 2-LTR circle formation | 1.998096e-01 | 0.699 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 2.134191e-01 | 0.671 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.217210e-01 | 0.915 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 1.931067e-01 | 0.714 |
| R-HSA-167161 | HIV Transcription Initiation | 2.055070e-01 | 0.687 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 2.055070e-01 | 0.687 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.368295e-01 | 0.626 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.616705e-01 | 0.791 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.055070e-01 | 0.687 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 2.305378e-01 | 0.637 |
| R-HSA-6798695 | Neutrophil degranulation | 1.230559e-01 | 0.910 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.566210e-01 | 0.805 |
| R-HSA-1236977 | Endosomal/Vacuolar pathway | 2.267979e-01 | 0.644 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 2.399499e-01 | 0.620 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 2.399499e-01 | 0.620 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.551294e-01 | 0.809 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.551294e-01 | 0.809 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 2.179906e-01 | 0.662 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 2.055070e-01 | 0.687 |
| R-HSA-72172 | mRNA Splicing | 1.890603e-01 | 0.723 |
| R-HSA-8963888 | Chylomicron assembly | 2.134191e-01 | 0.671 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.242574e-01 | 0.649 |
| R-HSA-416476 | G alpha (q) signalling events | 2.172920e-01 | 0.663 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.859656e-01 | 0.731 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.429852e-01 | 0.845 |
| R-HSA-3371378 | Regulation by c-FLIP | 1.718829e-01 | 0.765 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.859656e-01 | 0.731 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.998096e-01 | 0.699 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 2.267979e-01 | 0.644 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 1.592936e-01 | 0.798 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.447896e-01 | 0.839 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.575575e-01 | 0.803 |
| R-HSA-5694530 | Cargo concentration in the ER | 1.331336e-01 | 0.876 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 2.134191e-01 | 0.671 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.992951e-01 | 0.701 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.373403e-01 | 0.862 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.242574e-01 | 0.649 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.431834e-01 | 0.844 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.818977e-01 | 0.740 |
| R-HSA-69416 | Dimerization of procaspase-8 | 1.718829e-01 | 0.765 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.998096e-01 | 0.699 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 2.267979e-01 | 0.644 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 1.273967e-01 | 0.895 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.368295e-01 | 0.626 |
| R-HSA-9664873 | Pexophagy | 1.998096e-01 | 0.699 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.859656e-01 | 0.731 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.686407e-01 | 0.773 |
| R-HSA-167172 | Transcription of the HIV genome | 1.431086e-01 | 0.844 |
| R-HSA-5689603 | UCH proteinases | 1.758226e-01 | 0.755 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.429852e-01 | 0.845 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 1.575575e-01 | 0.803 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.718829e-01 | 0.765 |
| R-HSA-9683686 | Maturation of spike protein | 1.998096e-01 | 0.699 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.267979e-01 | 0.644 |
| R-HSA-446205 | Synthesis of GDP-mannose | 2.399499e-01 | 0.620 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.399499e-01 | 0.620 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.331336e-01 | 0.876 |
| R-HSA-9694548 | Maturation of spike protein | 1.992951e-01 | 0.701 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.998096e-01 | 0.699 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.747084e-01 | 0.758 |
| R-HSA-162592 | Integration of provirus | 2.267979e-01 | 0.644 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 1.506751e-01 | 0.822 |
| R-HSA-73927 | Depurination | 1.808105e-01 | 0.743 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 1.281618e-01 | 0.892 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 1.429852e-01 | 0.845 |
| R-HSA-448706 | Interleukin-1 processing | 1.859656e-01 | 0.731 |
| R-HSA-9697154 | Disorders of Nervous System Development | 2.399499e-01 | 0.620 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.399499e-01 | 0.620 |
| R-HSA-9005895 | Pervasive developmental disorders | 2.399499e-01 | 0.620 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.389280e-01 | 0.857 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.389280e-01 | 0.857 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.592049e-01 | 0.798 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.059635e-01 | 0.686 |
| R-HSA-5357801 | Programmed Cell Death | 1.916359e-01 | 0.718 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 1.718829e-01 | 0.765 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.859656e-01 | 0.731 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.200856e-01 | 0.921 |
| R-HSA-9659379 | Sensory processing of sound | 1.885889e-01 | 0.724 |
| R-HSA-8939211 | ESR-mediated signaling | 1.553633e-01 | 0.809 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.590137e-01 | 0.799 |
| R-HSA-210990 | PECAM1 interactions | 2.134191e-01 | 0.671 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.447764e-01 | 0.839 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.431086e-01 | 0.844 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.590137e-01 | 0.799 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.431834e-01 | 0.844 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.551294e-01 | 0.809 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.839503e-01 | 0.735 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.117396e-01 | 0.674 |
| R-HSA-162582 | Signal Transduction | 1.684096e-01 | 0.774 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 2.399499e-01 | 0.620 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.217210e-01 | 0.915 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 2.134191e-01 | 0.671 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.447764e-01 | 0.839 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.718829e-01 | 0.765 |
| R-HSA-9842663 | Signaling by LTK | 2.399499e-01 | 0.620 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.626106e-01 | 0.789 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.361666e-01 | 0.866 |
| R-HSA-9694635 | Translation of Structural Proteins | 1.800508e-01 | 0.745 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.280216e-01 | 0.893 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.686407e-01 | 0.773 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.667260e-01 | 0.778 |
| R-HSA-5663205 | Infectious disease | 2.058754e-01 | 0.686 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.843066e-01 | 0.734 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.924487e-01 | 0.716 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.633130e-01 | 0.787 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.510875e-01 | 0.821 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.127096e-01 | 0.672 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 2.117396e-01 | 0.674 |
| R-HSA-211000 | Gene Silencing by RNA | 1.494384e-01 | 0.826 |
| R-HSA-73928 | Depyrimidination | 2.117396e-01 | 0.674 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.566210e-01 | 0.805 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.200856e-01 | 0.921 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.686407e-01 | 0.773 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.869442e-01 | 0.728 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.431303e-01 | 0.614 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 2.462309e-01 | 0.609 |
| R-HSA-425410 | Metal ion SLC transporters | 2.494381e-01 | 0.603 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.528790e-01 | 0.597 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.528790e-01 | 0.597 |
| R-HSA-8963901 | Chylomicron remodeling | 2.528790e-01 | 0.597 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.528790e-01 | 0.597 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.528790e-01 | 0.597 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.528790e-01 | 0.597 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.553494e-01 | 0.593 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.602173e-01 | 0.585 |
| R-HSA-9658195 | Leishmania infection | 2.602173e-01 | 0.585 |
| R-HSA-9748787 | Azathioprine ADME | 2.620665e-01 | 0.582 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.655890e-01 | 0.576 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 2.655890e-01 | 0.576 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 2.655890e-01 | 0.576 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.655890e-01 | 0.576 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 2.655890e-01 | 0.576 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.655890e-01 | 0.576 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.655890e-01 | 0.576 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 2.655890e-01 | 0.576 |
| R-HSA-435354 | Zinc transporters | 2.655890e-01 | 0.576 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.683832e-01 | 0.571 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.746992e-01 | 0.561 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.746992e-01 | 0.561 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 2.780836e-01 | 0.556 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.780836e-01 | 0.556 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 2.780836e-01 | 0.556 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.780836e-01 | 0.556 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.780836e-01 | 0.556 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.780836e-01 | 0.556 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.780836e-01 | 0.556 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.780836e-01 | 0.556 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.783346e-01 | 0.555 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.783346e-01 | 0.555 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.810125e-01 | 0.551 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.810125e-01 | 0.551 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 2.810125e-01 | 0.551 |
| R-HSA-983712 | Ion channel transport | 2.863485e-01 | 0.543 |
| R-HSA-72649 | Translation initiation complex formation | 2.873215e-01 | 0.542 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.873215e-01 | 0.542 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 2.873215e-01 | 0.542 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.875869e-01 | 0.541 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.875869e-01 | 0.541 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.875869e-01 | 0.541 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.903663e-01 | 0.537 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 2.903663e-01 | 0.537 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.903663e-01 | 0.537 |
| R-HSA-9754706 | Atorvastatin ADME | 2.903663e-01 | 0.537 |
| R-HSA-5635838 | Activation of SMO | 2.903663e-01 | 0.537 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.922224e-01 | 0.534 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.936245e-01 | 0.532 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.949771e-01 | 0.530 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.999199e-01 | 0.523 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.999199e-01 | 0.523 |
| R-HSA-5578775 | Ion homeostasis | 2.999199e-01 | 0.523 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.006376e-01 | 0.522 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 3.024408e-01 | 0.519 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.024408e-01 | 0.519 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 3.024408e-01 | 0.519 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.024408e-01 | 0.519 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 3.024408e-01 | 0.519 |
| R-HSA-70370 | Galactose catabolism | 3.024408e-01 | 0.519 |
| R-HSA-9675151 | Disorders of Developmental Biology | 3.024408e-01 | 0.519 |
| R-HSA-195721 | Signaling by WNT | 3.053242e-01 | 0.515 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.061567e-01 | 0.514 |
| R-HSA-1483166 | Synthesis of PA | 3.062061e-01 | 0.514 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.124816e-01 | 0.505 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3.143105e-01 | 0.503 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 3.143105e-01 | 0.503 |
| R-HSA-2028269 | Signaling by Hippo | 3.143105e-01 | 0.503 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.179487e-01 | 0.498 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 3.259790e-01 | 0.487 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.259790e-01 | 0.487 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.259790e-01 | 0.487 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.294293e-01 | 0.482 |
| R-HSA-112043 | PLC beta mediated events | 3.312300e-01 | 0.480 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.312300e-01 | 0.480 |
| R-HSA-450294 | MAP kinase activation | 3.312300e-01 | 0.480 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.333461e-01 | 0.477 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.359131e-01 | 0.474 |
| R-HSA-1268020 | Mitochondrial protein import | 3.374489e-01 | 0.472 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.374489e-01 | 0.472 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.374497e-01 | 0.472 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.374497e-01 | 0.472 |
| R-HSA-9694631 | Maturation of nucleoprotein | 3.374497e-01 | 0.472 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.374497e-01 | 0.472 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.387390e-01 | 0.470 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.387390e-01 | 0.470 |
| R-HSA-73887 | Death Receptor Signaling | 3.410598e-01 | 0.467 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.433912e-01 | 0.464 |
| R-HSA-373755 | Semaphorin interactions | 3.436504e-01 | 0.464 |
| R-HSA-1989781 | PPARA activates gene expression | 3.449190e-01 | 0.462 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 3.487258e-01 | 0.458 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.487258e-01 | 0.458 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.487258e-01 | 0.458 |
| R-HSA-71288 | Creatine metabolism | 3.487258e-01 | 0.458 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 3.487258e-01 | 0.458 |
| R-HSA-9629569 | Protein hydroxylation | 3.487258e-01 | 0.458 |
| R-HSA-3322077 | Glycogen synthesis | 3.487258e-01 | 0.458 |
| R-HSA-211981 | Xenobiotics | 3.498332e-01 | 0.456 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.526400e-01 | 0.453 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.559963e-01 | 0.449 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.559963e-01 | 0.449 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.573301e-01 | 0.447 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.573301e-01 | 0.447 |
| R-HSA-202040 | G-protein activation | 3.598107e-01 | 0.444 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.598107e-01 | 0.444 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.598107e-01 | 0.444 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 3.598107e-01 | 0.444 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.598107e-01 | 0.444 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 3.598107e-01 | 0.444 |
| R-HSA-877300 | Interferon gamma signaling | 3.603620e-01 | 0.443 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 3.619684e-01 | 0.441 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.619684e-01 | 0.441 |
| R-HSA-112040 | G-protein mediated events | 3.682588e-01 | 0.434 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.707076e-01 | 0.431 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 3.707076e-01 | 0.431 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.707076e-01 | 0.431 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.707076e-01 | 0.431 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.707076e-01 | 0.431 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 3.707076e-01 | 0.431 |
| R-HSA-392499 | Metabolism of proteins | 3.711700e-01 | 0.430 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.727439e-01 | 0.429 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.758506e-01 | 0.425 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.814197e-01 | 0.419 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.814197e-01 | 0.419 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.814197e-01 | 0.419 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.814197e-01 | 0.419 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 3.814197e-01 | 0.419 |
| R-HSA-204005 | COPII-mediated vesicle transport | 3.864778e-01 | 0.413 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.864778e-01 | 0.413 |
| R-HSA-448424 | Interleukin-17 signaling | 3.864778e-01 | 0.413 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.909514e-01 | 0.408 |
| R-HSA-74160 | Gene expression (Transcription) | 3.912837e-01 | 0.408 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 3.919501e-01 | 0.407 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.919501e-01 | 0.407 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 3.919501e-01 | 0.407 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 3.919501e-01 | 0.407 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 3.919501e-01 | 0.407 |
| R-HSA-5693538 | Homology Directed Repair | 3.942631e-01 | 0.404 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.942631e-01 | 0.404 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.984963e-01 | 0.400 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.984963e-01 | 0.400 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.984963e-01 | 0.400 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.984963e-01 | 0.400 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.988453e-01 | 0.399 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.988453e-01 | 0.399 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.988453e-01 | 0.399 |
| R-HSA-211999 | CYP2E1 reactions | 4.023019e-01 | 0.395 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 4.023019e-01 | 0.395 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 4.023019e-01 | 0.395 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 4.023019e-01 | 0.395 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.023019e-01 | 0.395 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 4.023019e-01 | 0.395 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 4.023019e-01 | 0.395 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 4.023019e-01 | 0.395 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 4.023019e-01 | 0.395 |
| R-HSA-9865881 | Complex III assembly | 4.023019e-01 | 0.395 |
| R-HSA-9749641 | Aspirin ADME | 4.044647e-01 | 0.393 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.065514e-01 | 0.391 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.079809e-01 | 0.389 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.104048e-01 | 0.387 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.104048e-01 | 0.387 |
| R-HSA-9620244 | Long-term potentiation | 4.124780e-01 | 0.385 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 4.124780e-01 | 0.385 |
| R-HSA-420029 | Tight junction interactions | 4.124780e-01 | 0.385 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.124780e-01 | 0.385 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.124780e-01 | 0.385 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.124780e-01 | 0.385 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 4.124780e-01 | 0.385 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.125333e-01 | 0.385 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.125333e-01 | 0.385 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.170749e-01 | 0.380 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.180163e-01 | 0.379 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.203800e-01 | 0.376 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.221969e-01 | 0.374 |
| R-HSA-3295583 | TRP channels | 4.224816e-01 | 0.374 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4.224816e-01 | 0.374 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 4.224816e-01 | 0.374 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 4.224816e-01 | 0.374 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.256320e-01 | 0.371 |
| R-HSA-449147 | Signaling by Interleukins | 4.295161e-01 | 0.367 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.323154e-01 | 0.364 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.323154e-01 | 0.364 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 4.323154e-01 | 0.364 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 4.323154e-01 | 0.364 |
| R-HSA-201451 | Signaling by BMP | 4.323154e-01 | 0.364 |
| R-HSA-264876 | Insulin processing | 4.323154e-01 | 0.364 |
| R-HSA-114608 | Platelet degranulation | 4.396037e-01 | 0.357 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.419823e-01 | 0.355 |
| R-HSA-77387 | Insulin receptor recycling | 4.419823e-01 | 0.355 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 4.419823e-01 | 0.355 |
| R-HSA-9757110 | Prednisone ADME | 4.419823e-01 | 0.355 |
| R-HSA-622312 | Inflammasomes | 4.419823e-01 | 0.355 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.454102e-01 | 0.351 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 4.503771e-01 | 0.346 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 4.511326e-01 | 0.346 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.514852e-01 | 0.345 |
| R-HSA-72086 | mRNA Capping | 4.514852e-01 | 0.345 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.514852e-01 | 0.345 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.514852e-01 | 0.345 |
| R-HSA-157118 | Signaling by NOTCH | 4.602917e-01 | 0.337 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 4.608269e-01 | 0.336 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.608269e-01 | 0.336 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.608269e-01 | 0.336 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 4.608269e-01 | 0.336 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.608269e-01 | 0.336 |
| R-HSA-9843745 | Adipogenesis | 4.617953e-01 | 0.336 |
| R-HSA-5576891 | Cardiac conduction | 4.617953e-01 | 0.336 |
| R-HSA-9909396 | Circadian clock | 4.661888e-01 | 0.331 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.700100e-01 | 0.328 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.700100e-01 | 0.328 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.705666e-01 | 0.327 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.736819e-01 | 0.325 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.744284e-01 | 0.324 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.790373e-01 | 0.320 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.790373e-01 | 0.320 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.792318e-01 | 0.319 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.792318e-01 | 0.319 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.847459e-01 | 0.314 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.854770e-01 | 0.314 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 4.879114e-01 | 0.312 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.879114e-01 | 0.312 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.879114e-01 | 0.312 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 4.879114e-01 | 0.312 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.879131e-01 | 0.312 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.902238e-01 | 0.310 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.964833e-01 | 0.304 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 4.966349e-01 | 0.304 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 4.966349e-01 | 0.304 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.010694e-01 | 0.300 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 5.052102e-01 | 0.297 |
| R-HSA-392518 | Signal amplification | 5.052102e-01 | 0.297 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 5.052102e-01 | 0.297 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.052102e-01 | 0.297 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.052102e-01 | 0.297 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 5.052102e-01 | 0.297 |
| R-HSA-202424 | Downstream TCR signaling | 5.064365e-01 | 0.295 |
| R-HSA-5688426 | Deubiquitination | 5.090023e-01 | 0.293 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.117661e-01 | 0.291 |
| R-HSA-597592 | Post-translational protein modification | 5.127476e-01 | 0.290 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.136400e-01 | 0.289 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5.136400e-01 | 0.289 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.136400e-01 | 0.289 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 5.136400e-01 | 0.289 |
| R-HSA-169911 | Regulation of Apoptosis | 5.136400e-01 | 0.289 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 5.136400e-01 | 0.289 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.170578e-01 | 0.286 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.217534e-01 | 0.283 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 5.219267e-01 | 0.282 |
| R-HSA-74158 | RNA Polymerase III Transcription | 5.219267e-01 | 0.282 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 5.219267e-01 | 0.282 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 5.219267e-01 | 0.282 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5.219267e-01 | 0.282 |
| R-HSA-111933 | Calmodulin induced events | 5.219267e-01 | 0.282 |
| R-HSA-111997 | CaM pathway | 5.219267e-01 | 0.282 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 5.219267e-01 | 0.282 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.219267e-01 | 0.282 |
| R-HSA-9679506 | SARS-CoV Infections | 5.280294e-01 | 0.277 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 5.286810e-01 | 0.277 |
| R-HSA-1296072 | Voltage gated Potassium channels | 5.300728e-01 | 0.276 |
| R-HSA-4641258 | Degradation of DVL | 5.300728e-01 | 0.276 |
| R-HSA-4641257 | Degradation of AXIN | 5.300728e-01 | 0.276 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.300728e-01 | 0.276 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.300728e-01 | 0.276 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.327037e-01 | 0.274 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.378417e-01 | 0.269 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.380805e-01 | 0.269 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.429409e-01 | 0.265 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.429409e-01 | 0.265 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.429409e-01 | 0.265 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.459522e-01 | 0.263 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 5.459522e-01 | 0.263 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 5.459522e-01 | 0.263 |
| R-HSA-69541 | Stabilization of p53 | 5.459522e-01 | 0.263 |
| R-HSA-71336 | Pentose phosphate pathway | 5.459522e-01 | 0.263 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.530219e-01 | 0.257 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.536903e-01 | 0.257 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 5.536903e-01 | 0.257 |
| R-HSA-202433 | Generation of second messenger molecules | 5.536903e-01 | 0.257 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.536903e-01 | 0.257 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.536903e-01 | 0.257 |
| R-HSA-5260271 | Diseases of Immune System | 5.536903e-01 | 0.257 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 5.536903e-01 | 0.257 |
| R-HSA-8982491 | Glycogen metabolism | 5.536903e-01 | 0.257 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 5.612969e-01 | 0.251 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.612969e-01 | 0.251 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.612969e-01 | 0.251 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.612969e-01 | 0.251 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.678478e-01 | 0.246 |
| R-HSA-6811438 | Intra-Golgi traffic | 5.687744e-01 | 0.245 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 5.687744e-01 | 0.245 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.687744e-01 | 0.245 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.687744e-01 | 0.245 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.687744e-01 | 0.245 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.687744e-01 | 0.245 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.727105e-01 | 0.242 |
| R-HSA-165159 | MTOR signalling | 5.761249e-01 | 0.239 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.761249e-01 | 0.239 |
| R-HSA-111996 | Ca-dependent events | 5.761249e-01 | 0.239 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.761249e-01 | 0.239 |
| R-HSA-9711097 | Cellular response to starvation | 5.817594e-01 | 0.235 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 5.833505e-01 | 0.234 |
| R-HSA-9748784 | Drug ADME | 5.833945e-01 | 0.234 |
| R-HSA-111885 | Opioid Signalling | 5.870602e-01 | 0.231 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.870602e-01 | 0.231 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.887158e-01 | 0.230 |
| R-HSA-5683826 | Surfactant metabolism | 5.904534e-01 | 0.229 |
| R-HSA-69231 | Cyclin D associated events in G1 | 5.904534e-01 | 0.229 |
| R-HSA-69236 | G1 Phase | 5.904534e-01 | 0.229 |
| R-HSA-9907900 | Proteasome assembly | 5.904534e-01 | 0.229 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.947827e-01 | 0.226 |
| R-HSA-774815 | Nucleosome assembly | 5.974357e-01 | 0.224 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.974357e-01 | 0.224 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 5.974357e-01 | 0.224 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 5.974357e-01 | 0.224 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 5.974357e-01 | 0.224 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 5.974357e-01 | 0.224 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.974357e-01 | 0.224 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 5.974357e-01 | 0.224 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 5.974357e-01 | 0.224 |
| R-HSA-9824272 | Somitogenesis | 5.974357e-01 | 0.224 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.042993e-01 | 0.219 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.042993e-01 | 0.219 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.042993e-01 | 0.219 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.056348e-01 | 0.218 |
| R-HSA-212436 | Generic Transcription Pathway | 6.067849e-01 | 0.217 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.101787e-01 | 0.215 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.101787e-01 | 0.215 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.101787e-01 | 0.215 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.101787e-01 | 0.215 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 6.110463e-01 | 0.214 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.110463e-01 | 0.214 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 6.176787e-01 | 0.209 |
| R-HSA-202403 | TCR signaling | 6.191471e-01 | 0.208 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 6.241984e-01 | 0.205 |
| R-HSA-9766229 | Degradation of CDH1 | 6.241984e-01 | 0.205 |
| R-HSA-73893 | DNA Damage Bypass | 6.241984e-01 | 0.205 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.241984e-01 | 0.205 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 6.241984e-01 | 0.205 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 6.241984e-01 | 0.205 |
| R-HSA-72312 | rRNA processing | 6.281481e-01 | 0.202 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.287423e-01 | 0.202 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.357770e-01 | 0.197 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.366070e-01 | 0.196 |
| R-HSA-3371571 | HSF1-dependent transactivation | 6.369073e-01 | 0.196 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 6.369073e-01 | 0.196 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 6.369073e-01 | 0.196 |
| R-HSA-1643685 | Disease | 6.428932e-01 | 0.192 |
| R-HSA-72187 | mRNA 3'-end processing | 6.431003e-01 | 0.192 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 6.431003e-01 | 0.192 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 6.431003e-01 | 0.192 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.450998e-01 | 0.190 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 6.491880e-01 | 0.188 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.492872e-01 | 0.188 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.492872e-01 | 0.188 |
| R-HSA-909733 | Interferon alpha/beta signaling | 6.492872e-01 | 0.188 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.534354e-01 | 0.185 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.534354e-01 | 0.185 |
| R-HSA-72766 | Translation | 6.534908e-01 | 0.185 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.551722e-01 | 0.184 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.575445e-01 | 0.182 |
| R-HSA-9753281 | Paracetamol ADME | 6.610547e-01 | 0.180 |
| R-HSA-75893 | TNF signaling | 6.668372e-01 | 0.176 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.668372e-01 | 0.176 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.668372e-01 | 0.176 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.668372e-01 | 0.176 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.725214e-01 | 0.172 |
| R-HSA-3371556 | Cellular response to heat stress | 6.735931e-01 | 0.172 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 6.781090e-01 | 0.169 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.836016e-01 | 0.165 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.852261e-01 | 0.164 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.852261e-01 | 0.164 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 6.890008e-01 | 0.162 |
| R-HSA-351202 | Metabolism of polyamines | 6.890008e-01 | 0.162 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.890008e-01 | 0.162 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.890008e-01 | 0.162 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.890008e-01 | 0.162 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.890008e-01 | 0.162 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.890008e-01 | 0.162 |
| R-HSA-379724 | tRNA Aminoacylation | 6.890008e-01 | 0.162 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.943082e-01 | 0.158 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 6.943082e-01 | 0.158 |
| R-HSA-9707616 | Heme signaling | 6.995253e-01 | 0.155 |
| R-HSA-6784531 | tRNA processing in the nucleus | 6.995253e-01 | 0.155 |
| R-HSA-6799198 | Complex I biogenesis | 7.046537e-01 | 0.152 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 7.046537e-01 | 0.152 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 7.046537e-01 | 0.152 |
| R-HSA-936837 | Ion transport by P-type ATPases | 7.096949e-01 | 0.149 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 7.096949e-01 | 0.149 |
| R-HSA-1474244 | Extracellular matrix organization | 7.200398e-01 | 0.143 |
| R-HSA-5693606 | DNA Double Strand Break Response | 7.243098e-01 | 0.140 |
| R-HSA-5218859 | Regulated Necrosis | 7.290167e-01 | 0.137 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.381915e-01 | 0.132 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.383788e-01 | 0.132 |
| R-HSA-975634 | Retinoid metabolism and transport | 7.426622e-01 | 0.129 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 7.470568e-01 | 0.127 |
| R-HSA-6807070 | PTEN Regulation | 7.480452e-01 | 0.126 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.513767e-01 | 0.124 |
| R-HSA-4086398 | Ca2+ pathway | 7.513767e-01 | 0.124 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 7.556230e-01 | 0.122 |
| R-HSA-9013694 | Signaling by NOTCH4 | 7.556230e-01 | 0.122 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 7.556230e-01 | 0.122 |
| R-HSA-8852135 | Protein ubiquitination | 7.597970e-01 | 0.119 |
| R-HSA-917937 | Iron uptake and transport | 7.597970e-01 | 0.119 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 7.597970e-01 | 0.119 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 7.597970e-01 | 0.119 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 7.634760e-01 | 0.117 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.639000e-01 | 0.117 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 7.679332e-01 | 0.115 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 7.718977e-01 | 0.112 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 7.718977e-01 | 0.112 |
| R-HSA-5619084 | ABC transporter disorders | 7.718977e-01 | 0.112 |
| R-HSA-4086400 | PCP/CE pathway | 7.718977e-01 | 0.112 |
| R-HSA-216083 | Integrin cell surface interactions | 7.718977e-01 | 0.112 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 7.757948e-01 | 0.110 |
| R-HSA-9758941 | Gastrulation | 7.809081e-01 | 0.107 |
| R-HSA-8951664 | Neddylation | 7.826223e-01 | 0.106 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 7.833909e-01 | 0.106 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 7.833909e-01 | 0.106 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.837019e-01 | 0.106 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.870923e-01 | 0.104 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.891959e-01 | 0.103 |
| R-HSA-1483257 | Phospholipid metabolism | 7.893946e-01 | 0.103 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.907306e-01 | 0.102 |
| R-HSA-9609507 | Protein localization | 7.918967e-01 | 0.101 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.978225e-01 | 0.098 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 8.012781e-01 | 0.096 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 8.012781e-01 | 0.096 |
| R-HSA-9610379 | HCMV Late Events | 8.023975e-01 | 0.096 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 8.046749e-01 | 0.094 |
| R-HSA-388396 | GPCR downstream signalling | 8.049198e-01 | 0.094 |
| R-HSA-70268 | Pyruvate metabolism | 8.080138e-01 | 0.093 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.099627e-01 | 0.092 |
| R-HSA-156902 | Peptide chain elongation | 8.112959e-01 | 0.091 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 8.208103e-01 | 0.086 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.266216e-01 | 0.083 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.268862e-01 | 0.083 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 8.268862e-01 | 0.083 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.298467e-01 | 0.081 |
| R-HSA-2029481 | FCGR activation | 8.298467e-01 | 0.081 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.327568e-01 | 0.079 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.356172e-01 | 0.078 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 8.356172e-01 | 0.078 |
| R-HSA-1296071 | Potassium Channels | 8.411928e-01 | 0.075 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.419592e-01 | 0.075 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.419592e-01 | 0.075 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.439094e-01 | 0.074 |
| R-HSA-422356 | Regulation of insulin secretion | 8.465798e-01 | 0.072 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.492047e-01 | 0.071 |
| R-HSA-70171 | Glycolysis | 8.517848e-01 | 0.070 |
| R-HSA-382556 | ABC-family proteins mediated transport | 8.517848e-01 | 0.070 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.543209e-01 | 0.068 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 8.568138e-01 | 0.067 |
| R-HSA-192823 | Viral mRNA Translation | 8.592642e-01 | 0.066 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.616728e-01 | 0.065 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.616728e-01 | 0.065 |
| R-HSA-9833110 | RSV-host interactions | 8.640403e-01 | 0.063 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.644968e-01 | 0.063 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.676698e-01 | 0.062 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 8.709033e-01 | 0.060 |
| R-HSA-9700206 | Signaling by ALK in cancer | 8.709033e-01 | 0.060 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.775918e-01 | 0.057 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 8.856042e-01 | 0.053 |
| R-HSA-372790 | Signaling by GPCR | 8.905628e-01 | 0.050 |
| R-HSA-70326 | Glucose metabolism | 8.950718e-01 | 0.048 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.950718e-01 | 0.048 |
| R-HSA-6805567 | Keratinization | 9.003337e-01 | 0.046 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 9.020804e-01 | 0.045 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 9.054077e-01 | 0.043 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 9.117282e-01 | 0.040 |
| R-HSA-8956319 | Nucleotide catabolism | 9.161909e-01 | 0.038 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 9.176279e-01 | 0.037 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 9.204286e-01 | 0.036 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.276952e-01 | 0.033 |
| R-HSA-163685 | Integration of energy metabolism | 9.282743e-01 | 0.032 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 9.295048e-01 | 0.032 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 9.364584e-01 | 0.029 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 9.386209e-01 | 0.028 |
| R-HSA-2187338 | Visual phototransduction | 9.417280e-01 | 0.026 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.439991e-01 | 0.025 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 9.465619e-01 | 0.024 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.492683e-01 | 0.023 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 9.509962e-01 | 0.022 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.565950e-01 | 0.019 |
| R-HSA-5619102 | SLC transporter disorders | 9.587949e-01 | 0.018 |
| R-HSA-382551 | Transport of small molecules | 9.594939e-01 | 0.018 |
| R-HSA-72306 | tRNA processing | 9.615562e-01 | 0.017 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.642173e-01 | 0.016 |
| R-HSA-611105 | Respiratory electron transport | 9.665378e-01 | 0.015 |
| R-HSA-168255 | Influenza Infection | 9.671134e-01 | 0.015 |
| R-HSA-3781865 | Diseases of glycosylation | 9.698469e-01 | 0.013 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.751503e-01 | 0.011 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.858257e-01 | 0.006 |
| R-HSA-15869 | Metabolism of nucleotides | 9.880019e-01 | 0.005 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.887046e-01 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 9.949619e-01 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.987206e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.991909e-01 | 0.000 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.992040e-01 | 0.000 |
| R-HSA-8978868 | Fatty acid metabolism | 9.994098e-01 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 9.995851e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999295e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999996e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.887 | 0.134 | 2 | 0.841 |
CLK3 |
0.875 | 0.181 | 1 | 0.863 |
CDC7 |
0.875 | -0.003 | 1 | 0.848 |
DSTYK |
0.875 | 0.049 | 2 | 0.843 |
PRPK |
0.873 | -0.096 | -1 | 0.856 |
PIM3 |
0.873 | 0.068 | -3 | 0.823 |
CAMK2G |
0.872 | 0.037 | 2 | 0.815 |
TBK1 |
0.872 | 0.006 | 1 | 0.800 |
IKKB |
0.872 | -0.047 | -2 | 0.808 |
MOS |
0.871 | 0.028 | 1 | 0.865 |
RAF1 |
0.871 | -0.030 | 1 | 0.883 |
CAMK1B |
0.871 | 0.043 | -3 | 0.866 |
MTOR |
0.871 | -0.087 | 1 | 0.848 |
GCN2 |
0.870 | -0.127 | 2 | 0.757 |
NLK |
0.870 | 0.070 | 1 | 0.875 |
NDR2 |
0.870 | 0.022 | -3 | 0.833 |
PDHK4 |
0.869 | -0.182 | 1 | 0.888 |
BMPR2 |
0.869 | -0.050 | -2 | 0.925 |
MARK4 |
0.867 | 0.119 | 4 | 0.919 |
PRKD1 |
0.867 | 0.069 | -3 | 0.825 |
ATR |
0.867 | 0.012 | 1 | 0.866 |
IKKE |
0.866 | -0.042 | 1 | 0.797 |
WNK1 |
0.866 | 0.053 | -2 | 0.891 |
MAPKAPK3 |
0.866 | 0.080 | -3 | 0.783 |
RSK2 |
0.865 | 0.073 | -3 | 0.772 |
TGFBR2 |
0.865 | 0.022 | -2 | 0.839 |
FAM20C |
0.865 | 0.240 | 2 | 0.705 |
AMPKA1 |
0.865 | 0.119 | -3 | 0.856 |
PDHK1 |
0.865 | -0.146 | 1 | 0.882 |
CDKL1 |
0.865 | 0.027 | -3 | 0.797 |
ERK5 |
0.865 | 0.046 | 1 | 0.841 |
PRKD2 |
0.865 | 0.094 | -3 | 0.768 |
ULK2 |
0.864 | -0.155 | 2 | 0.745 |
LATS2 |
0.864 | 0.046 | -5 | 0.800 |
CAMK2D |
0.864 | 0.052 | -3 | 0.848 |
PIM1 |
0.864 | 0.108 | -3 | 0.771 |
NDR1 |
0.864 | 0.023 | -3 | 0.835 |
PKN3 |
0.863 | 0.002 | -3 | 0.829 |
MST4 |
0.863 | 0.045 | 2 | 0.793 |
NIK |
0.863 | 0.000 | -3 | 0.885 |
MAPKAPK2 |
0.863 | 0.103 | -3 | 0.724 |
NUAK2 |
0.863 | 0.044 | -3 | 0.838 |
SKMLCK |
0.863 | 0.061 | -2 | 0.872 |
CAMK2B |
0.862 | 0.139 | 2 | 0.802 |
IKKA |
0.862 | 0.011 | -2 | 0.800 |
CAMLCK |
0.862 | 0.019 | -2 | 0.865 |
HUNK |
0.861 | -0.061 | 2 | 0.756 |
RIPK3 |
0.861 | -0.019 | 3 | 0.737 |
ATM |
0.861 | 0.084 | 1 | 0.810 |
GRK1 |
0.861 | 0.085 | -2 | 0.835 |
P90RSK |
0.861 | 0.034 | -3 | 0.772 |
WNK3 |
0.861 | -0.075 | 1 | 0.847 |
SRPK1 |
0.861 | 0.081 | -3 | 0.740 |
DAPK2 |
0.860 | 0.012 | -3 | 0.872 |
BCKDK |
0.860 | -0.085 | -1 | 0.809 |
SRPK2 |
0.860 | 0.097 | -3 | 0.666 |
AMPKA2 |
0.860 | 0.105 | -3 | 0.824 |
NEK7 |
0.860 | -0.149 | -3 | 0.831 |
GRK6 |
0.859 | 0.033 | 1 | 0.865 |
CDKL5 |
0.859 | 0.035 | -3 | 0.790 |
HIPK4 |
0.859 | 0.059 | 1 | 0.817 |
KIS |
0.859 | 0.081 | 1 | 0.743 |
NEK6 |
0.859 | -0.105 | -2 | 0.892 |
P70S6KB |
0.859 | 0.042 | -3 | 0.801 |
TSSK1 |
0.859 | 0.112 | -3 | 0.877 |
ALK4 |
0.858 | 0.107 | -2 | 0.888 |
TSSK2 |
0.858 | 0.088 | -5 | 0.868 |
TGFBR1 |
0.857 | 0.138 | -2 | 0.867 |
GRK5 |
0.857 | -0.150 | -3 | 0.845 |
CAMK2A |
0.857 | 0.094 | 2 | 0.793 |
PKCD |
0.857 | 0.030 | 2 | 0.745 |
PKN2 |
0.856 | -0.010 | -3 | 0.841 |
MLK1 |
0.856 | -0.121 | 2 | 0.760 |
BMPR1B |
0.856 | 0.161 | 1 | 0.818 |
RSK3 |
0.856 | 0.019 | -3 | 0.775 |
ICK |
0.856 | 0.022 | -3 | 0.828 |
PKACG |
0.856 | 0.023 | -2 | 0.740 |
CDK8 |
0.856 | 0.055 | 1 | 0.735 |
ULK1 |
0.855 | -0.177 | -3 | 0.809 |
CHAK2 |
0.855 | -0.071 | -1 | 0.867 |
NIM1 |
0.854 | -0.035 | 3 | 0.753 |
PLK1 |
0.853 | 0.006 | -2 | 0.846 |
DLK |
0.852 | -0.157 | 1 | 0.876 |
LATS1 |
0.852 | 0.081 | -3 | 0.851 |
DNAPK |
0.852 | 0.107 | 1 | 0.776 |
NEK9 |
0.852 | -0.154 | 2 | 0.780 |
QSK |
0.852 | 0.085 | 4 | 0.901 |
ALK2 |
0.852 | 0.132 | -2 | 0.871 |
MARK3 |
0.852 | 0.144 | 4 | 0.883 |
MASTL |
0.852 | -0.268 | -2 | 0.852 |
PRKD3 |
0.851 | 0.046 | -3 | 0.750 |
CLK1 |
0.851 | 0.118 | -3 | 0.749 |
MARK2 |
0.851 | 0.141 | 4 | 0.847 |
MELK |
0.851 | 0.037 | -3 | 0.816 |
ANKRD3 |
0.851 | -0.122 | 1 | 0.880 |
GRK4 |
0.851 | -0.113 | -2 | 0.872 |
AURC |
0.851 | 0.046 | -2 | 0.645 |
CLK4 |
0.851 | 0.085 | -3 | 0.765 |
PAK1 |
0.851 | 0.000 | -2 | 0.791 |
CAMK4 |
0.850 | -0.057 | -3 | 0.827 |
BRSK1 |
0.850 | 0.048 | -3 | 0.800 |
SIK |
0.850 | 0.068 | -3 | 0.763 |
QIK |
0.850 | -0.001 | -3 | 0.843 |
MNK2 |
0.850 | 0.014 | -2 | 0.793 |
NUAK1 |
0.850 | 0.014 | -3 | 0.799 |
PAK3 |
0.849 | -0.034 | -2 | 0.795 |
SRPK3 |
0.849 | 0.044 | -3 | 0.712 |
CDK19 |
0.849 | 0.047 | 1 | 0.696 |
CDK7 |
0.849 | 0.043 | 1 | 0.731 |
PLK3 |
0.848 | 0.043 | 2 | 0.750 |
TTBK2 |
0.848 | -0.149 | 2 | 0.666 |
CHK1 |
0.848 | 0.046 | -3 | 0.852 |
DYRK2 |
0.848 | 0.077 | 1 | 0.738 |
RSK4 |
0.848 | 0.068 | -3 | 0.730 |
SMG1 |
0.848 | 0.016 | 1 | 0.819 |
MSK2 |
0.848 | -0.028 | -3 | 0.737 |
MLK2 |
0.848 | -0.159 | 2 | 0.769 |
GRK7 |
0.848 | 0.092 | 1 | 0.805 |
RIPK1 |
0.848 | -0.190 | 1 | 0.822 |
PAK6 |
0.847 | 0.047 | -2 | 0.707 |
PKR |
0.847 | -0.021 | 1 | 0.842 |
MSK1 |
0.847 | 0.030 | -3 | 0.750 |
ACVR2B |
0.847 | 0.069 | -2 | 0.855 |
ACVR2A |
0.847 | 0.062 | -2 | 0.840 |
MARK1 |
0.846 | 0.099 | 4 | 0.894 |
JNK2 |
0.846 | 0.118 | 1 | 0.681 |
BRSK2 |
0.846 | 0.011 | -3 | 0.829 |
IRE1 |
0.846 | -0.115 | 1 | 0.792 |
AURB |
0.846 | 0.030 | -2 | 0.645 |
JNK3 |
0.845 | 0.093 | 1 | 0.710 |
IRE2 |
0.845 | -0.048 | 2 | 0.726 |
MYLK4 |
0.844 | 0.012 | -2 | 0.782 |
PKACB |
0.844 | 0.054 | -2 | 0.669 |
PHKG1 |
0.844 | -0.045 | -3 | 0.825 |
SGK3 |
0.844 | 0.052 | -3 | 0.776 |
PIM2 |
0.844 | 0.073 | -3 | 0.750 |
MLK3 |
0.844 | -0.087 | 2 | 0.696 |
CDK5 |
0.843 | 0.069 | 1 | 0.746 |
NEK2 |
0.843 | -0.086 | 2 | 0.750 |
MAPKAPK5 |
0.843 | -0.063 | -3 | 0.730 |
PAK2 |
0.843 | -0.041 | -2 | 0.776 |
YSK4 |
0.843 | -0.121 | 1 | 0.830 |
MEK1 |
0.843 | -0.185 | 2 | 0.782 |
PKCB |
0.842 | -0.023 | 2 | 0.683 |
PKCA |
0.842 | -0.023 | 2 | 0.680 |
CDK1 |
0.842 | 0.067 | 1 | 0.689 |
VRK2 |
0.842 | -0.213 | 1 | 0.892 |
CDK2 |
0.842 | 0.044 | 1 | 0.768 |
PKG2 |
0.842 | 0.025 | -2 | 0.665 |
P38A |
0.842 | 0.072 | 1 | 0.756 |
CLK2 |
0.842 | 0.126 | -3 | 0.744 |
PKCG |
0.842 | -0.040 | 2 | 0.691 |
TLK2 |
0.842 | -0.044 | 1 | 0.847 |
MNK1 |
0.842 | 0.003 | -2 | 0.804 |
CDK18 |
0.842 | 0.082 | 1 | 0.658 |
BMPR1A |
0.841 | 0.132 | 1 | 0.796 |
BRAF |
0.840 | -0.022 | -4 | 0.829 |
CDK13 |
0.840 | 0.017 | 1 | 0.702 |
DCAMKL1 |
0.840 | 0.026 | -3 | 0.788 |
AKT2 |
0.840 | 0.030 | -3 | 0.687 |
PRKX |
0.839 | 0.082 | -3 | 0.676 |
MLK4 |
0.839 | -0.098 | 2 | 0.675 |
PKCH |
0.839 | -0.052 | 2 | 0.673 |
P38B |
0.838 | 0.080 | 1 | 0.690 |
HIPK1 |
0.838 | 0.088 | 1 | 0.754 |
AURA |
0.838 | -0.009 | -2 | 0.617 |
CHAK1 |
0.838 | -0.156 | 2 | 0.725 |
P38G |
0.837 | 0.081 | 1 | 0.606 |
ERK2 |
0.837 | 0.038 | 1 | 0.722 |
WNK4 |
0.837 | -0.058 | -2 | 0.881 |
ERK1 |
0.837 | 0.056 | 1 | 0.682 |
HRI |
0.837 | -0.146 | -2 | 0.888 |
CAMK1G |
0.837 | -0.010 | -3 | 0.760 |
SNRK |
0.837 | -0.148 | 2 | 0.647 |
SSTK |
0.837 | 0.088 | 4 | 0.883 |
PERK |
0.836 | -0.129 | -2 | 0.871 |
GRK2 |
0.836 | -0.047 | -2 | 0.768 |
PRP4 |
0.836 | 0.048 | -3 | 0.777 |
CDK17 |
0.835 | 0.061 | 1 | 0.609 |
DRAK1 |
0.835 | -0.085 | 1 | 0.797 |
DYRK1A |
0.835 | 0.046 | 1 | 0.780 |
TLK1 |
0.835 | -0.065 | -2 | 0.886 |
HIPK2 |
0.834 | 0.083 | 1 | 0.651 |
CDK9 |
0.834 | 0.005 | 1 | 0.709 |
CAMK1D |
0.834 | 0.051 | -3 | 0.697 |
MEKK1 |
0.834 | -0.135 | 1 | 0.852 |
PKCZ |
0.834 | -0.108 | 2 | 0.725 |
PLK4 |
0.834 | -0.117 | 2 | 0.606 |
SMMLCK |
0.833 | -0.012 | -3 | 0.823 |
P70S6K |
0.833 | 0.007 | -3 | 0.720 |
CDK16 |
0.833 | 0.110 | 1 | 0.625 |
DCAMKL2 |
0.833 | -0.015 | -3 | 0.815 |
ZAK |
0.832 | -0.141 | 1 | 0.836 |
CDK12 |
0.832 | 0.016 | 1 | 0.677 |
NEK5 |
0.832 | -0.096 | 1 | 0.853 |
CDK3 |
0.832 | 0.088 | 1 | 0.626 |
DYRK4 |
0.832 | 0.080 | 1 | 0.671 |
PKACA |
0.832 | 0.034 | -2 | 0.613 |
DYRK1B |
0.832 | 0.075 | 1 | 0.695 |
PINK1 |
0.831 | -0.170 | 1 | 0.848 |
MEKK3 |
0.831 | -0.181 | 1 | 0.846 |
PHKG2 |
0.831 | -0.027 | -3 | 0.810 |
CDK14 |
0.831 | 0.069 | 1 | 0.703 |
MST3 |
0.831 | -0.035 | 2 | 0.766 |
AKT1 |
0.831 | 0.034 | -3 | 0.708 |
HIPK3 |
0.830 | 0.037 | 1 | 0.754 |
MEK5 |
0.830 | -0.276 | 2 | 0.767 |
IRAK4 |
0.830 | -0.099 | 1 | 0.800 |
CK2A2 |
0.830 | 0.152 | 1 | 0.696 |
MEKK2 |
0.830 | -0.134 | 2 | 0.753 |
PASK |
0.829 | -0.032 | -3 | 0.835 |
PAK5 |
0.828 | -0.009 | -2 | 0.646 |
TAO3 |
0.828 | -0.077 | 1 | 0.842 |
MPSK1 |
0.828 | -0.007 | 1 | 0.805 |
TTBK1 |
0.827 | -0.138 | 2 | 0.598 |
DYRK3 |
0.827 | 0.049 | 1 | 0.751 |
DAPK3 |
0.827 | 0.043 | -3 | 0.793 |
PKCT |
0.827 | -0.054 | 2 | 0.683 |
CDK10 |
0.827 | 0.079 | 1 | 0.685 |
TAO2 |
0.826 | -0.062 | 2 | 0.802 |
P38D |
0.826 | 0.080 | 1 | 0.621 |
GAK |
0.826 | 0.009 | 1 | 0.858 |
CAMKK1 |
0.826 | -0.143 | -2 | 0.809 |
LKB1 |
0.825 | -0.060 | -3 | 0.848 |
IRAK1 |
0.825 | -0.188 | -1 | 0.800 |
PAK4 |
0.824 | -0.015 | -2 | 0.647 |
ERK7 |
0.824 | 0.003 | 2 | 0.495 |
CK1E |
0.823 | -0.092 | -3 | 0.480 |
GCK |
0.823 | -0.013 | 1 | 0.860 |
MRCKA |
0.823 | 0.075 | -3 | 0.762 |
CAMKK2 |
0.822 | -0.124 | -2 | 0.796 |
PLK2 |
0.822 | 0.068 | -3 | 0.843 |
NEK8 |
0.822 | -0.188 | 2 | 0.766 |
TNIK |
0.822 | 0.020 | 3 | 0.821 |
PKCI |
0.822 | -0.065 | 2 | 0.688 |
MST2 |
0.822 | -0.057 | 1 | 0.860 |
TAK1 |
0.821 | -0.046 | 1 | 0.884 |
JNK1 |
0.821 | 0.053 | 1 | 0.663 |
NEK11 |
0.821 | -0.203 | 1 | 0.844 |
HGK |
0.821 | -0.033 | 3 | 0.812 |
PKCE |
0.821 | -0.010 | 2 | 0.676 |
GSK3B |
0.821 | -0.047 | 4 | 0.447 |
NEK4 |
0.821 | -0.101 | 1 | 0.826 |
MEKK6 |
0.821 | -0.080 | 1 | 0.850 |
MRCKB |
0.820 | 0.059 | -3 | 0.745 |
MINK |
0.820 | -0.032 | 1 | 0.846 |
EEF2K |
0.819 | -0.050 | 3 | 0.799 |
DAPK1 |
0.819 | 0.008 | -3 | 0.776 |
PDK1 |
0.819 | -0.123 | 1 | 0.815 |
GSK3A |
0.819 | -0.007 | 4 | 0.457 |
PDHK3_TYR |
0.819 | 0.095 | 4 | 0.917 |
ROCK2 |
0.819 | 0.079 | -3 | 0.793 |
GRK3 |
0.819 | -0.059 | -2 | 0.725 |
CAMK1A |
0.819 | 0.032 | -3 | 0.650 |
SGK1 |
0.819 | 0.045 | -3 | 0.608 |
CHK2 |
0.819 | 0.001 | -3 | 0.638 |
CK2A1 |
0.818 | 0.118 | 1 | 0.674 |
CDK6 |
0.818 | 0.048 | 1 | 0.681 |
PKN1 |
0.817 | -0.036 | -3 | 0.737 |
HPK1 |
0.817 | -0.023 | 1 | 0.842 |
SBK |
0.817 | 0.046 | -3 | 0.566 |
LOK |
0.817 | -0.041 | -2 | 0.792 |
MAP3K15 |
0.816 | -0.122 | 1 | 0.822 |
AKT3 |
0.816 | 0.028 | -3 | 0.618 |
MST1 |
0.816 | -0.055 | 1 | 0.840 |
CDK4 |
0.816 | 0.043 | 1 | 0.664 |
LRRK2 |
0.815 | -0.168 | 2 | 0.793 |
NEK1 |
0.815 | -0.097 | 1 | 0.821 |
KHS1 |
0.814 | 0.014 | 1 | 0.834 |
VRK1 |
0.813 | -0.169 | 2 | 0.802 |
KHS2 |
0.813 | 0.032 | 1 | 0.850 |
CK1D |
0.812 | -0.103 | -3 | 0.420 |
CK1G1 |
0.812 | -0.137 | -3 | 0.470 |
TESK1_TYR |
0.812 | -0.063 | 3 | 0.839 |
MAK |
0.812 | 0.071 | -2 | 0.719 |
MOK |
0.812 | 0.065 | 1 | 0.750 |
PBK |
0.810 | -0.002 | 1 | 0.778 |
DMPK1 |
0.810 | 0.076 | -3 | 0.756 |
PDHK4_TYR |
0.809 | -0.017 | 2 | 0.840 |
EPHA6 |
0.809 | 0.087 | -1 | 0.873 |
CK1A2 |
0.809 | -0.112 | -3 | 0.422 |
SLK |
0.809 | -0.096 | -2 | 0.741 |
BMPR2_TYR |
0.809 | 0.000 | -1 | 0.869 |
MEK2 |
0.808 | -0.240 | 2 | 0.754 |
BUB1 |
0.808 | 0.017 | -5 | 0.816 |
PKG1 |
0.808 | -0.011 | -2 | 0.583 |
MAP2K7_TYR |
0.808 | -0.211 | 2 | 0.822 |
RIPK2 |
0.807 | -0.251 | 1 | 0.789 |
YSK1 |
0.807 | -0.108 | 2 | 0.745 |
PKMYT1_TYR |
0.807 | -0.137 | 3 | 0.806 |
MAP2K6_TYR |
0.807 | -0.102 | -1 | 0.874 |
MAP2K4_TYR |
0.807 | -0.188 | -1 | 0.870 |
ROCK1 |
0.807 | 0.052 | -3 | 0.762 |
PINK1_TYR |
0.806 | -0.170 | 1 | 0.859 |
STK33 |
0.806 | -0.190 | 2 | 0.586 |
CRIK |
0.806 | 0.067 | -3 | 0.698 |
LIMK2_TYR |
0.805 | -0.043 | -3 | 0.897 |
EPHB4 |
0.805 | 0.036 | -1 | 0.863 |
PDHK1_TYR |
0.804 | -0.098 | -1 | 0.883 |
RET |
0.804 | -0.053 | 1 | 0.840 |
DDR1 |
0.803 | -0.038 | 4 | 0.859 |
TTK |
0.803 | -0.006 | -2 | 0.855 |
NEK3 |
0.802 | -0.160 | 1 | 0.798 |
MST1R |
0.802 | -0.079 | 3 | 0.775 |
BIKE |
0.801 | 0.036 | 1 | 0.734 |
TYRO3 |
0.801 | -0.074 | 3 | 0.760 |
TYK2 |
0.801 | -0.138 | 1 | 0.841 |
ROS1 |
0.799 | -0.079 | 3 | 0.739 |
OSR1 |
0.799 | -0.118 | 2 | 0.729 |
CSF1R |
0.798 | -0.049 | 3 | 0.763 |
JAK2 |
0.798 | -0.123 | 1 | 0.843 |
ASK1 |
0.797 | -0.128 | 1 | 0.810 |
YES1 |
0.797 | -0.005 | -1 | 0.842 |
LIMK1_TYR |
0.797 | -0.221 | 2 | 0.816 |
TXK |
0.797 | 0.069 | 1 | 0.848 |
SRMS |
0.796 | 0.003 | 1 | 0.869 |
EPHA4 |
0.796 | -0.009 | 2 | 0.752 |
EPHB1 |
0.796 | -0.014 | 1 | 0.874 |
ABL2 |
0.796 | -0.015 | -1 | 0.817 |
INSRR |
0.795 | -0.035 | 3 | 0.722 |
TNK2 |
0.795 | -0.021 | 3 | 0.722 |
TAO1 |
0.794 | -0.100 | 1 | 0.777 |
FER |
0.794 | -0.106 | 1 | 0.883 |
HCK |
0.794 | -0.028 | -1 | 0.846 |
FGFR2 |
0.794 | -0.060 | 3 | 0.768 |
HASPIN |
0.794 | -0.046 | -1 | 0.714 |
JAK3 |
0.794 | -0.088 | 1 | 0.827 |
EPHB3 |
0.794 | -0.025 | -1 | 0.854 |
EPHB2 |
0.794 | 0.006 | -1 | 0.846 |
MYO3B |
0.794 | -0.100 | 2 | 0.769 |
ITK |
0.793 | -0.023 | -1 | 0.837 |
PDGFRB |
0.793 | -0.100 | 3 | 0.764 |
BLK |
0.792 | 0.076 | -1 | 0.843 |
ALPHAK3 |
0.792 | -0.065 | -1 | 0.773 |
LCK |
0.792 | 0.026 | -1 | 0.845 |
AXL |
0.792 | -0.036 | 3 | 0.754 |
TNNI3K_TYR |
0.791 | -0.017 | 1 | 0.839 |
FGR |
0.791 | -0.129 | 1 | 0.870 |
MERTK |
0.791 | -0.012 | 3 | 0.756 |
MYO3A |
0.791 | -0.106 | 1 | 0.810 |
TEK |
0.791 | -0.083 | 3 | 0.704 |
ABL1 |
0.790 | -0.057 | -1 | 0.809 |
FLT3 |
0.790 | -0.114 | 3 | 0.755 |
KDR |
0.789 | -0.064 | 3 | 0.741 |
FGFR1 |
0.789 | -0.104 | 3 | 0.740 |
NEK10_TYR |
0.789 | -0.093 | 1 | 0.732 |
KIT |
0.789 | -0.118 | 3 | 0.759 |
TEC |
0.789 | -0.020 | -1 | 0.776 |
EPHA7 |
0.788 | -0.010 | 2 | 0.749 |
TNK1 |
0.787 | -0.103 | 3 | 0.742 |
JAK1 |
0.787 | -0.066 | 1 | 0.801 |
BTK |
0.786 | -0.115 | -1 | 0.809 |
BMX |
0.786 | -0.041 | -1 | 0.747 |
EPHA1 |
0.786 | -0.027 | 3 | 0.737 |
PDGFRA |
0.786 | -0.173 | 3 | 0.762 |
EPHA3 |
0.785 | -0.080 | 2 | 0.729 |
FYN |
0.785 | 0.034 | -1 | 0.813 |
STLK3 |
0.785 | -0.174 | 1 | 0.802 |
ALK |
0.784 | -0.126 | 3 | 0.675 |
LTK |
0.784 | -0.105 | 3 | 0.703 |
DDR2 |
0.784 | 0.015 | 3 | 0.705 |
NTRK1 |
0.783 | -0.150 | -1 | 0.820 |
MET |
0.783 | -0.107 | 3 | 0.748 |
PTK6 |
0.782 | -0.177 | -1 | 0.762 |
AAK1 |
0.782 | 0.057 | 1 | 0.629 |
EPHA5 |
0.782 | -0.013 | 2 | 0.741 |
FGFR3 |
0.782 | -0.099 | 3 | 0.746 |
PTK2B |
0.781 | -0.026 | -1 | 0.800 |
FRK |
0.781 | -0.065 | -1 | 0.862 |
NTRK2 |
0.781 | -0.146 | 3 | 0.725 |
ERBB2 |
0.780 | -0.146 | 1 | 0.807 |
WEE1_TYR |
0.780 | -0.150 | -1 | 0.775 |
YANK3 |
0.780 | -0.129 | 2 | 0.399 |
FLT4 |
0.780 | -0.140 | 3 | 0.733 |
LYN |
0.779 | -0.060 | 3 | 0.683 |
INSR |
0.779 | -0.136 | 3 | 0.699 |
FLT1 |
0.778 | -0.128 | -1 | 0.841 |
EPHA8 |
0.777 | -0.048 | -1 | 0.826 |
NTRK3 |
0.775 | -0.144 | -1 | 0.769 |
EGFR |
0.774 | -0.065 | 1 | 0.720 |
SRC |
0.773 | -0.069 | -1 | 0.801 |
PTK2 |
0.773 | 0.023 | -1 | 0.800 |
CK1A |
0.772 | -0.141 | -3 | 0.324 |
CSK |
0.771 | -0.139 | 2 | 0.754 |
MATK |
0.770 | -0.151 | -1 | 0.730 |
EPHA2 |
0.767 | -0.062 | -1 | 0.795 |
FGFR4 |
0.767 | -0.108 | -1 | 0.772 |
SYK |
0.765 | -0.026 | -1 | 0.778 |
IGF1R |
0.765 | -0.138 | 3 | 0.637 |
MUSK |
0.762 | -0.177 | 1 | 0.704 |
ERBB4 |
0.759 | -0.065 | 1 | 0.733 |
CK1G3 |
0.752 | -0.146 | -3 | 0.272 |
YANK2 |
0.749 | -0.149 | 2 | 0.417 |
FES |
0.749 | -0.172 | -1 | 0.718 |
ZAP70 |
0.734 | -0.121 | -1 | 0.694 |
CK1G2 |
0.731 | -0.142 | -3 | 0.377 |