Motif 71 (n=92)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RRH5 | WDR27 | Y757 | psp | WD repeat-containing protein 27 | None |
| A6NJZ7 | RIMBP3C | S314 | ochoa | RIMS-binding protein 3C (RIM-BP3.C) (RIMS-binding protein 3.3) (RIM-BP3.3) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| A6NNM3 | RIMBP3B | S314 | ochoa | RIMS-binding protein 3B (RIM-BP3.B) (RIMS-binding protein 3.2) (RIM-BP3.2) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| B2RXF5 | ZBTB42 | S328 | ochoa | Zinc finger and BTB domain-containing protein 42 | Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. {ECO:0000250|UniProtKB:Q811H0}. |
| E9PCH4 | None | S779 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| O14579 | COPE | S95 | ochoa | Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| O15027 | SEC16A | S1278 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15417 | TNRC18 | S2292 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O15503 | INSIG1 | S238 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
| O43314 | PPIP5K2 | S1152 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O43566 | RGS14 | S203 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
| O43663 | PRC1 | S513 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O60333 | KIF1B | S893 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O60674 | JAK2 | S523 | ochoa|psp | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:15690087, PubMed:7615558, PubMed:9657743, PubMed:15899890). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:15690087, PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain (PubMed:9657743). Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). Up-regulates the potassium voltage-gated channel activity of KCNA3 (PubMed:25644777). {ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:15690087, ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:21368206, ECO:0000269|PubMed:21423214, ECO:0000269|PubMed:25644777, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:9618263, ECO:0000269|PubMed:9657743}. |
| O60711 | LPXN | S267 | ochoa | Leupaxin | Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}. |
| O94979 | SEC31A | S188 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| O95071 | UBR5 | S110 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| P06239 | LCK | S194 | ochoa|psp | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P08651 | NFIC | S427 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P10827 | THRA | S199 | ochoa | Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha) | [Isoform Alpha-1]: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:19926848}.; FUNCTION: [Isoform Alpha-2]: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. {ECO:0000269|PubMed:8910441}. |
| P15884 | TCF4 | S372 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P23508 | MCC | S316 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P33993 | MCM7 | S121 | ochoa|psp | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35916 | FLT4 | S953 | ochoa | Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| P42224 | STAT1 | S532 | ochoa | Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) | Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:12764129, PubMed:12855578, PubMed:15322115, PubMed:23940278, PubMed:34508746, PubMed:35568036, PubMed:9724754). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426, PubMed:35568036). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state (PubMed:28753426, PubMed:35568036). In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state (PubMed:8156998). Becomes activated in response to KITLG/SCF and KIT signaling (PubMed:15526160). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:19088846). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylated at Thr-749 by IKBKB which promotes binding of STAT1 to the 5'-TTTGAGGC-3' sequence in the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). Phosphorylation at Thr-749 also promotes binding of STAT1 to the 5'-TTTGAGTC-3' sequence in the IL12B promoter and activation of IL12B transcription (PubMed:32209697). Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine (By similarity). {ECO:0000250|UniProtKB:P42225, ECO:0000269|PubMed:12764129, ECO:0000269|PubMed:12855578, ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:23940278, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:34508746, ECO:0000269|PubMed:35568036, ECO:0000269|PubMed:8156998, ECO:0000269|PubMed:9724754, ECO:0000303|PubMed:15526160}. |
| P46531 | NOTCH1 | S2136 | ochoa | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P48742 | LHX1 | S142 | ochoa | LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (hLim-1) | Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. {ECO:0000269|PubMed:9212161}. |
| P51003 | PAPOLA | S537 | ochoa|psp | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P51587 | BRCA2 | S492 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P78364 | PHC1 | S669 | ochoa | Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. {ECO:0000269|PubMed:23418308}. |
| Q00325 | SLC25A3 | S33 | ochoa | Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP) | Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity) (PubMed:17273968, PubMed:29237729). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity) (PubMed:17273968). Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity). {ECO:0000250|UniProtKB:P12234, ECO:0000250|UniProtKB:P16036, ECO:0000269|PubMed:17273968, ECO:0000269|PubMed:29237729}. |
| Q00536 | CDK16 | S138 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q00537 | CDK17 | S165 | ochoa | Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) | May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}. |
| Q02952 | AKAP12 | S1727 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q0VD86 | INCA1 | S23 | psp | Protein INCA1 (Inhibitor of CDK interacting with cyclin A1) | Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity). {ECO:0000250|UniProtKB:Q6PKN7, ECO:0000269|PubMed:21540187}. |
| Q13950 | RUNX2 | S347 | psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14244 | MAP7 | S169 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14679 | TTLL4 | S1143 | ochoa | Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4) | Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. {ECO:0000250|UniProtKB:Q80UG8}. |
| Q4LE39 | ARID4B | S930 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q5FBB7 | SGO1 | S507 | psp | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}. |
| Q5SYE7 | NHSL1 | S1467 | ochoa | NHS-like protein 1 | None |
| Q5T200 | ZC3H13 | S64 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T5X7 | BEND3 | S710 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5TC79 | ZBTB37 | S195 | ochoa | Zinc finger and BTB domain-containing protein 37 | May be involved in transcriptional regulation. |
| Q5TC79 | ZBTB37 | S310 | ochoa | Zinc finger and BTB domain-containing protein 37 | May be involved in transcriptional regulation. |
| Q5VWQ8 | DAB2IP | S957 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q641Q2 | WASHC2A | S704 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68DK7 | MSL1 | S401 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6IE81 | JADE1 | S703 | ochoa | Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22654112, ECO:0000269|PubMed:24065767}. |
| Q70EL4 | USP43 | S226 | ochoa | Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) | May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}. |
| Q7L5Y9 | MAEA | S311 | ochoa | E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP) | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable). {ECO:0000250|UniProtKB:Q4VC33, ECO:0000269|PubMed:29911972, ECO:0000269|PubMed:9763581, ECO:0000305|PubMed:16510120}. |
| Q7Z2K8 | GPRIN1 | S452 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z2Z1 | TICRR | S1187 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q8IUG5 | MYO18B | S2542 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IV36 | HID1 | S653 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8IY92 | SLX4 | S1070 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IZW8 | TNS4 | S169 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8TAA9 | VANGL1 | S45 | ochoa | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | None |
| Q8TEU7 | RAPGEF6 | S729 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8TF72 | SHROOM3 | S734 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUZ0 | BCL7C | S80 | ochoa | B-cell CLL/lymphoma 7 protein family member C | May play an anti-apoptotic role. {ECO:0000250}. |
| Q8WX93 | PALLD | S484 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WXX7 | AUTS2 | S1225 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q92618 | ZNF516 | S116 | ochoa | Zinc finger protein 516 | Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422). {ECO:0000250|UniProtKB:Q7TSH3, ECO:0000269|PubMed:23446422}. |
| Q96AY4 | TTC28 | S2302 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96EK9 | KTI12 | S205 | ochoa | Protein KTI12 homolog | None |
| Q96PE2 | ARHGEF17 | S418 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PE2 | ARHGEF17 | S946 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96QD9 | FYTTD1 | S118 | ochoa | UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) | Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}. |
| Q99959 | PKP2 | S44 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BUR4 | WRAP53 | S54 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BV19 | C1orf50 | S43 | ochoa | Uncharacterized protein C1orf50 | None |
| Q9BY89 | KIAA1671 | S56 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZC7 | ABCA2 | S1238 | ochoa | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}. |
| Q9BZF2 | OSBPL7 | S236 | ochoa | Oxysterol-binding protein-related protein 7 (ORP-7) (OSBP-related protein 7) | None |
| Q9C0C2 | TNKS1BP1 | S672 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H4B6 | SAV1 | S56 | ochoa | Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29063833). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:29063833}. |
| Q9H6A9 | PCNX3 | S402 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H910 | JPT2 | S30 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9HCH5 | SYTL2 | S322 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NPI6 | DCP1A | S353 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NVF7 | FBXO28 | S235 | ochoa | F-box only protein 28 | Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}. |
| Q9NZ71 | RTEL1 | S791 | ochoa | Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) | A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}. |
| Q9P2F8 | SIPA1L2 | S148 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9P2K3 | RCOR3 | S33 | ochoa | REST corepressor 3 | May act as a component of a corepressor complex that represses transcription. {ECO:0000305}. |
| Q9UBZ4 | APEX2 | S246 | ochoa | DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) | Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities (PubMed:16687656, PubMed:19443450, PubMed:32516598). Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (PubMed:16687656, PubMed:19443450). Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates (PubMed:16687656). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents (PubMed:16687656, PubMed:19443450). In the nucleus functions in the PCNA-dependent BER pathway (PubMed:11376153). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). {ECO:0000250|UniProtKB:Q68G58, ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:16687656, ECO:0000269|PubMed:19443450, ECO:0000269|PubMed:32516598}. |
| Q9UFD9 | RIMBP3 | S314 | ochoa | RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| Q9UMS6 | SYNPO2 | S310 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q13950 | RUNX2 | S24 | EPSD|PSP | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| P17936 | IGFBP3 | S97 | Sugiyama | Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:15371331, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}. |
| Q96HN2 | AHCYL2 | S107 | Sugiyama | Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.13.2.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) | May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705). {ECO:0000250|UniProtKB:A6QLP2, ECO:0000269|PubMed:19220705}. |
| P51451 | BLK | S190 | Sugiyama | Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) | Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Also phosphorylates the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Also contributes to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214). {ECO:0000250|UniProtKB:P16277, ECO:0000269|PubMed:19667185, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:8756631}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.000035 | 4.453 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.000035 | 4.453 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.000059 | 4.230 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.000192 | 3.716 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.000346 | 3.460 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.000711 | 3.148 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.000964 | 3.016 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.001064 | 2.973 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.000995 | 3.002 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.000964 | 3.016 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.000660 | 3.181 |
| R-HSA-74160 | Gene expression (Transcription) | 0.001502 | 2.823 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.002252 | 2.647 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.002341 | 2.631 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.002612 | 2.583 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.003243 | 2.489 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.003243 | 2.489 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.003538 | 2.451 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.003746 | 2.426 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.004852 | 2.314 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.004852 | 2.314 |
| R-HSA-9758941 | Gastrulation | 0.004535 | 2.343 |
| R-HSA-212436 | Generic Transcription Pathway | 0.004966 | 2.304 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.004037 | 2.394 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.005155 | 2.288 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.006090 | 2.215 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.005454 | 2.263 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.006090 | 2.215 |
| R-HSA-157118 | Signaling by NOTCH | 0.006693 | 2.174 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.007576 | 2.121 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.007386 | 2.132 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.007386 | 2.132 |
| R-HSA-9831926 | Nephron development | 0.009739 | 2.011 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 0.012712 | 1.896 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 0.012712 | 1.896 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.010774 | 1.968 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.012645 | 1.898 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.012201 | 1.914 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.013201 | 1.879 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.015104 | 1.821 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.015104 | 1.821 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.014139 | 1.850 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.017118 | 1.767 |
| R-HSA-9830364 | Formation of the nephric duct | 0.017118 | 1.767 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.016007 | 1.796 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.019008 | 1.721 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.020338 | 1.692 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.021464 | 1.668 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.020338 | 1.692 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.022615 | 1.646 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.026216 | 1.581 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.026754 | 1.573 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.026216 | 1.581 |
| R-HSA-4839726 | Chromatin organization | 0.029694 | 1.527 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.026216 | 1.581 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.031351 | 1.504 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.031480 | 1.502 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.037658 | 1.424 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.037658 | 1.424 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.037658 | 1.424 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.049896 | 1.302 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.049896 | 1.302 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.055956 | 1.252 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.061979 | 1.208 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.061979 | 1.208 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.061979 | 1.208 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.061979 | 1.208 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.079820 | 1.098 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.097324 | 1.012 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.097324 | 1.012 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.097324 | 1.012 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.108811 | 0.963 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.114499 | 0.941 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.142408 | 0.846 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.142408 | 0.846 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.147884 | 0.830 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.147884 | 0.830 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.147884 | 0.830 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.147884 | 0.830 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.147884 | 0.830 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.169445 | 0.771 |
| R-HSA-72187 | mRNA 3'-end processing | 0.056955 | 1.244 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.174750 | 0.758 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.067260 | 1.172 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.200777 | 0.697 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.200777 | 0.697 |
| R-HSA-390522 | Striated Muscle Contraction | 0.225991 | 0.646 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.230938 | 0.637 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.185260 | 0.732 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.205884 | 0.686 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.103086 | 0.987 |
| R-HSA-2586552 | Signaling by Leptin | 0.079820 | 1.098 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.230938 | 0.637 |
| R-HSA-4641265 | Repression of WNT target genes | 0.097324 | 1.012 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.097324 | 1.012 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.190465 | 0.720 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.235854 | 0.627 |
| R-HSA-9020933 | Interleukin-23 signaling | 0.067964 | 1.168 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.103086 | 0.987 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.125769 | 0.900 |
| R-HSA-2424491 | DAP12 signaling | 0.205884 | 0.686 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.150037 | 0.824 |
| R-HSA-176974 | Unwinding of DNA | 0.073911 | 1.131 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.103086 | 0.987 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.136896 | 0.864 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.164106 | 0.785 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.072628 | 1.139 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.225991 | 0.646 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.046683 | 1.331 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.067964 | 1.168 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.126163 | 0.899 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.050397 | 1.298 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.089505 | 1.048 |
| R-HSA-9824272 | Somitogenesis | 0.045723 | 1.340 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.153443 | 0.814 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.073911 | 1.131 |
| R-HSA-2028269 | Signaling by Hippo | 0.131350 | 0.882 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.147884 | 0.830 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.072628 | 1.139 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.108811 | 0.963 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.047598 | 1.322 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.089820 | 1.047 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.049896 | 1.302 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.073911 | 1.131 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.125769 | 0.900 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.136896 | 0.864 |
| R-HSA-5693538 | Homology Directed Repair | 0.053274 | 1.273 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.174750 | 0.758 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.180021 | 0.745 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.180021 | 0.745 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.055956 | 1.252 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.037658 | 1.424 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 0.049896 | 1.302 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.079820 | 1.098 |
| R-HSA-425381 | Bicarbonate transporters | 0.085692 | 1.067 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.114499 | 0.941 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.120152 | 0.920 |
| R-HSA-429947 | Deadenylation of mRNA | 0.174750 | 0.758 |
| R-HSA-9839394 | TGFBR3 expression | 0.180021 | 0.745 |
| R-HSA-180786 | Extension of Telomeres | 0.069034 | 1.161 |
| R-HSA-9830369 | Kidney development | 0.083757 | 1.077 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.168802 | 0.773 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.190465 | 0.720 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.200777 | 0.697 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.221012 | 0.656 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.045723 | 1.340 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.230938 | 0.637 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.152252 | 0.817 |
| R-HSA-157579 | Telomere Maintenance | 0.152252 | 0.817 |
| R-HSA-164944 | Nef and signal transduction | 0.055956 | 1.252 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.061979 | 1.208 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.108811 | 0.963 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.114499 | 0.941 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.069034 | 1.161 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.062033 | 1.207 |
| R-HSA-9945266 | Differentiation of T cells | 0.120152 | 0.920 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.120152 | 0.920 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.230938 | 0.637 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.101528 | 0.993 |
| R-HSA-73886 | Chromosome Maintenance | 0.213982 | 0.670 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.169445 | 0.771 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.235854 | 0.627 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.108811 | 0.963 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.114499 | 0.941 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.164106 | 0.785 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.167925 | 0.775 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.097359 | 1.012 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.147884 | 0.830 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.158733 | 0.799 |
| R-HSA-210990 | PECAM1 interactions | 0.085692 | 1.067 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.114499 | 0.941 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.114499 | 0.941 |
| R-HSA-525793 | Myogenesis | 0.185260 | 0.732 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.169445 | 0.771 |
| R-HSA-69190 | DNA strand elongation | 0.216001 | 0.666 |
| R-HSA-3214847 | HATs acetylate histones | 0.156700 | 0.805 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.193066 | 0.714 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.103086 | 0.987 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.169445 | 0.771 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.052577 | 1.279 |
| R-HSA-1640170 | Cell Cycle | 0.186133 | 0.730 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.158733 | 0.799 |
| R-HSA-5673000 | RAF activation | 0.230938 | 0.637 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.240739 | 0.618 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.136896 | 0.864 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.164106 | 0.785 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.093557 | 1.029 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.131350 | 0.882 |
| R-HSA-73894 | DNA Repair | 0.226245 | 0.645 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.050427 | 1.297 |
| R-HSA-186763 | Downstream signal transduction | 0.210958 | 0.676 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.216001 | 0.666 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.080704 | 1.093 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.124224 | 0.906 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.187795 | 0.726 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.085692 | 1.067 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.213982 | 0.670 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.099334 | 1.003 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.083736 | 1.077 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.221012 | 0.656 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.240739 | 0.618 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.240739 | 0.618 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.216001 | 0.666 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.212268 | 0.673 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.220509 | 0.657 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.124041 | 0.906 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.136899 | 0.864 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.244533 | 0.612 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.245593 | 0.610 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.250416 | 0.601 |
| R-HSA-8875878 | MET promotes cell motility | 0.250416 | 0.601 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.250416 | 0.601 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.255209 | 0.593 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.255209 | 0.593 |
| R-HSA-913531 | Interferon Signaling | 0.259379 | 0.586 |
| R-HSA-202433 | Generation of second messenger molecules | 0.259972 | 0.585 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.263435 | 0.579 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.264704 | 0.577 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.264704 | 0.577 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.264704 | 0.577 |
| R-HSA-9607240 | FLT3 Signaling | 0.264704 | 0.577 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.269406 | 0.570 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.269406 | 0.570 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.274079 | 0.562 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.274079 | 0.562 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.282348 | 0.549 |
| R-HSA-2172127 | DAP12 interactions | 0.283335 | 0.548 |
| R-HSA-69236 | G1 Phase | 0.283335 | 0.548 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.283335 | 0.548 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.283335 | 0.548 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.287919 | 0.541 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.291795 | 0.535 |
| R-HSA-9675135 | Diseases of DNA repair | 0.292475 | 0.534 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.292475 | 0.534 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.292475 | 0.534 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.292475 | 0.534 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.292475 | 0.534 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.292475 | 0.534 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.292475 | 0.534 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.294154 | 0.531 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.297001 | 0.527 |
| R-HSA-162582 | Signal Transduction | 0.300971 | 0.521 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.301499 | 0.521 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.305968 | 0.514 |
| R-HSA-73893 | DNA Damage Bypass | 0.305968 | 0.514 |
| R-HSA-9679506 | SARS-CoV Infections | 0.308606 | 0.511 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.310409 | 0.508 |
| R-HSA-877300 | Interferon gamma signaling | 0.312988 | 0.504 |
| R-HSA-912446 | Meiotic recombination | 0.314822 | 0.502 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.315335 | 0.501 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.319206 | 0.496 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.332195 | 0.479 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.336469 | 0.473 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.336469 | 0.473 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.340717 | 0.468 |
| R-HSA-186712 | Regulation of beta-cell development | 0.349132 | 0.457 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.352619 | 0.453 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.353299 | 0.452 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.353299 | 0.452 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.353299 | 0.452 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.353299 | 0.452 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.353299 | 0.452 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.353299 | 0.452 |
| R-HSA-983189 | Kinesins | 0.353299 | 0.452 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.353299 | 0.452 |
| R-HSA-186797 | Signaling by PDGF | 0.361554 | 0.442 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.371013 | 0.431 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.373742 | 0.427 |
| R-HSA-69275 | G2/M Transition | 0.377859 | 0.423 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.382406 | 0.417 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.393545 | 0.405 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.397431 | 0.401 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.397431 | 0.401 |
| R-HSA-449147 | Signaling by Interleukins | 0.397444 | 0.401 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.401292 | 0.397 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.405128 | 0.392 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.405128 | 0.392 |
| R-HSA-4086398 | Ca2+ pathway | 0.405128 | 0.392 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.405128 | 0.392 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.408940 | 0.388 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.409388 | 0.388 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.412728 | 0.384 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.416492 | 0.380 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.416492 | 0.380 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.420964 | 0.376 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.423948 | 0.373 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.423948 | 0.373 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.427641 | 0.369 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.431310 | 0.365 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.431310 | 0.365 |
| R-HSA-9833482 | PKR-mediated signaling | 0.431310 | 0.365 |
| R-HSA-6806834 | Signaling by MET | 0.431310 | 0.365 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.438579 | 0.358 |
| R-HSA-1500620 | Meiosis | 0.449310 | 0.347 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.449310 | 0.347 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.452841 | 0.344 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.452841 | 0.344 |
| R-HSA-70268 | Pyruvate metabolism | 0.459837 | 0.337 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.459837 | 0.337 |
| R-HSA-202424 | Downstream TCR signaling | 0.470166 | 0.328 |
| R-HSA-391251 | Protein folding | 0.480298 | 0.318 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.483633 | 0.315 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.483633 | 0.315 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.486946 | 0.313 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.496761 | 0.304 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.499991 | 0.301 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.503201 | 0.298 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.506390 | 0.296 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.506390 | 0.296 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.509559 | 0.293 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.509559 | 0.293 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.515836 | 0.287 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.515836 | 0.287 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.520087 | 0.284 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.532675 | 0.274 |
| R-HSA-69239 | Synthesis of DNA | 0.534195 | 0.272 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.540160 | 0.267 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.540160 | 0.267 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.541257 | 0.267 |
| R-HSA-202403 | TCR signaling | 0.543115 | 0.265 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.543115 | 0.265 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.548967 | 0.260 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.548967 | 0.260 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.548967 | 0.260 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.551803 | 0.258 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.557606 | 0.254 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.563016 | 0.249 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.568870 | 0.245 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.571641 | 0.243 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.572209 | 0.242 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.579850 | 0.237 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.585236 | 0.233 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.585236 | 0.233 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.585236 | 0.233 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.587903 | 0.231 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.587903 | 0.231 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.590177 | 0.229 |
| R-HSA-69206 | G1/S Transition | 0.593187 | 0.227 |
| R-HSA-194138 | Signaling by VEGF | 0.593187 | 0.227 |
| R-HSA-114608 | Platelet degranulation | 0.598403 | 0.223 |
| R-HSA-69481 | G2/M Checkpoints | 0.598403 | 0.223 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.600690 | 0.221 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.602422 | 0.220 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.604367 | 0.219 |
| R-HSA-195721 | Signaling by WNT | 0.605870 | 0.218 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.606104 | 0.217 |
| R-HSA-1474165 | Reproduction | 0.608638 | 0.216 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.616144 | 0.210 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.623690 | 0.205 |
| R-HSA-199991 | Membrane Trafficking | 0.624002 | 0.205 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.625932 | 0.203 |
| R-HSA-6807070 | PTEN Regulation | 0.633109 | 0.199 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.647092 | 0.189 |
| R-HSA-8957322 | Metabolism of steroids | 0.648669 | 0.188 |
| R-HSA-69242 | S Phase | 0.656064 | 0.183 |
| R-HSA-69306 | DNA Replication | 0.667002 | 0.176 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.669148 | 0.174 |
| R-HSA-73887 | Death Receptor Signaling | 0.669148 | 0.174 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.676113 | 0.170 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.677596 | 0.169 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.683424 | 0.165 |
| R-HSA-1280218 | Adaptive Immune System | 0.684777 | 0.164 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.689869 | 0.161 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.708815 | 0.149 |
| R-HSA-2559583 | Cellular Senescence | 0.722185 | 0.141 |
| R-HSA-1266738 | Developmental Biology | 0.727206 | 0.138 |
| R-HSA-3781865 | Diseases of glycosylation | 0.729290 | 0.137 |
| R-HSA-68877 | Mitotic Prometaphase | 0.744626 | 0.128 |
| R-HSA-9824446 | Viral Infection Pathways | 0.750903 | 0.124 |
| R-HSA-109582 | Hemostasis | 0.762532 | 0.118 |
| R-HSA-6805567 | Keratinization | 0.766788 | 0.115 |
| R-HSA-397014 | Muscle contraction | 0.775693 | 0.110 |
| R-HSA-68882 | Mitotic Anaphase | 0.781442 | 0.107 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.782403 | 0.107 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.782856 | 0.106 |
| R-HSA-162906 | HIV Infection | 0.796509 | 0.099 |
| R-HSA-2262752 | Cellular responses to stress | 0.801441 | 0.096 |
| R-HSA-8953854 | Metabolism of RNA | 0.803183 | 0.095 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.809312 | 0.092 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.903223 | 0.044 |
| R-HSA-597592 | Post-translational protein modification | 0.921914 | 0.035 |
| R-HSA-68886 | M Phase | 0.926504 | 0.033 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.926984 | 0.033 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.933395 | 0.030 |
| R-HSA-418594 | G alpha (i) signalling events | 0.937630 | 0.028 |
| R-HSA-5668914 | Diseases of metabolism | 0.945315 | 0.024 |
| R-HSA-1643685 | Disease | 0.965184 | 0.015 |
| R-HSA-388396 | GPCR downstream signalling | 0.965492 | 0.015 |
| R-HSA-5663205 | Infectious disease | 0.968531 | 0.014 |
| R-HSA-372790 | Signaling by GPCR | 0.978455 | 0.009 |
| R-HSA-392499 | Metabolism of proteins | 0.980079 | 0.009 |
| R-HSA-382551 | Transport of small molecules | 0.989524 | 0.005 |
| R-HSA-168256 | Immune System | 0.995731 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.999538 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999879 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.861 | 0.807 | 1 | 0.906 |
CDK17 |
0.858 | 0.815 | 1 | 0.925 |
P38G |
0.854 | 0.824 | 1 | 0.935 |
CDK19 |
0.853 | 0.765 | 1 | 0.900 |
HIPK2 |
0.851 | 0.736 | 1 | 0.900 |
KIS |
0.850 | 0.690 | 1 | 0.857 |
ERK1 |
0.850 | 0.791 | 1 | 0.901 |
CDK8 |
0.850 | 0.767 | 1 | 0.876 |
CDK7 |
0.848 | 0.769 | 1 | 0.876 |
CDK16 |
0.848 | 0.784 | 1 | 0.914 |
DYRK2 |
0.848 | 0.730 | 1 | 0.845 |
JNK2 |
0.846 | 0.821 | 1 | 0.914 |
CDK13 |
0.846 | 0.773 | 1 | 0.892 |
CDK1 |
0.846 | 0.759 | 1 | 0.896 |
CDK14 |
0.845 | 0.792 | 1 | 0.887 |
P38B |
0.844 | 0.786 | 1 | 0.889 |
CDK12 |
0.844 | 0.774 | 1 | 0.907 |
CDK3 |
0.843 | 0.694 | 1 | 0.922 |
P38D |
0.842 | 0.795 | 1 | 0.920 |
DYRK4 |
0.842 | 0.738 | 1 | 0.914 |
CDK5 |
0.841 | 0.742 | 1 | 0.851 |
JNK3 |
0.839 | 0.805 | 1 | 0.893 |
HIPK1 |
0.838 | 0.683 | 1 | 0.832 |
P38A |
0.837 | 0.765 | 1 | 0.836 |
DYRK1B |
0.836 | 0.711 | 1 | 0.877 |
CDK10 |
0.836 | 0.727 | 1 | 0.895 |
CDK9 |
0.835 | 0.757 | 1 | 0.890 |
HIPK4 |
0.835 | 0.482 | 1 | 0.653 |
NLK |
0.833 | 0.711 | 1 | 0.676 |
ERK2 |
0.833 | 0.776 | 1 | 0.858 |
HIPK3 |
0.831 | 0.669 | 1 | 0.803 |
CDK4 |
0.828 | 0.764 | 1 | 0.912 |
CLK3 |
0.828 | 0.453 | 1 | 0.617 |
CDK6 |
0.828 | 0.739 | 1 | 0.894 |
DYRK1A |
0.825 | 0.599 | 1 | 0.802 |
SRPK1 |
0.823 | 0.345 | -3 | 0.775 |
ERK5 |
0.823 | 0.402 | 1 | 0.588 |
DYRK3 |
0.822 | 0.560 | 1 | 0.801 |
CDK2 |
0.820 | 0.576 | 1 | 0.810 |
MTOR |
0.819 | 0.251 | 1 | 0.484 |
JNK1 |
0.818 | 0.716 | 1 | 0.913 |
ICK |
0.814 | 0.374 | -3 | 0.855 |
MAK |
0.813 | 0.510 | -2 | 0.784 |
CDKL5 |
0.811 | 0.195 | -3 | 0.820 |
CLK1 |
0.809 | 0.405 | -3 | 0.756 |
SRPK2 |
0.809 | 0.273 | -3 | 0.702 |
CDKL1 |
0.808 | 0.177 | -3 | 0.824 |
CLK4 |
0.808 | 0.379 | -3 | 0.767 |
COT |
0.805 | -0.079 | 2 | 0.828 |
CLK2 |
0.804 | 0.393 | -3 | 0.743 |
MOK |
0.804 | 0.477 | 1 | 0.728 |
IKKB |
0.803 | -0.096 | -2 | 0.852 |
SRPK3 |
0.802 | 0.242 | -3 | 0.751 |
TBK1 |
0.800 | -0.122 | 1 | 0.302 |
CDC7 |
0.799 | -0.098 | 1 | 0.316 |
PRP4 |
0.799 | 0.402 | -3 | 0.692 |
RAF1 |
0.798 | -0.122 | 1 | 0.327 |
DSTYK |
0.798 | -0.079 | 2 | 0.865 |
PRPK |
0.798 | -0.084 | -1 | 0.862 |
IKKE |
0.798 | -0.122 | 1 | 0.302 |
ERK7 |
0.797 | 0.317 | 2 | 0.611 |
MOS |
0.797 | -0.028 | 1 | 0.365 |
PDHK4 |
0.796 | -0.110 | 1 | 0.386 |
NEK6 |
0.796 | -0.027 | -2 | 0.882 |
GCN2 |
0.796 | -0.147 | 2 | 0.817 |
PIM3 |
0.795 | -0.014 | -3 | 0.826 |
ULK2 |
0.795 | -0.145 | 2 | 0.774 |
ATR |
0.795 | -0.044 | 1 | 0.345 |
WNK1 |
0.794 | -0.020 | -2 | 0.941 |
PDHK1 |
0.794 | -0.107 | 1 | 0.369 |
NDR2 |
0.794 | -0.006 | -3 | 0.824 |
MST4 |
0.794 | -0.016 | 2 | 0.817 |
NEK7 |
0.793 | -0.108 | -3 | 0.846 |
CAMK1B |
0.792 | -0.019 | -3 | 0.859 |
PKN3 |
0.791 | -0.018 | -3 | 0.825 |
MLK1 |
0.791 | -0.090 | 2 | 0.797 |
PRKD1 |
0.790 | 0.005 | -3 | 0.846 |
RIPK3 |
0.790 | -0.086 | 3 | 0.841 |
PKCD |
0.790 | 0.013 | 2 | 0.792 |
NIK |
0.790 | -0.027 | -3 | 0.861 |
BMPR2 |
0.790 | -0.163 | -2 | 0.915 |
CAMK2G |
0.789 | -0.048 | 2 | 0.833 |
CAMLCK |
0.789 | 0.024 | -2 | 0.911 |
NUAK2 |
0.789 | 0.015 | -3 | 0.829 |
SKMLCK |
0.789 | -0.011 | -2 | 0.908 |
P90RSK |
0.788 | 0.020 | -3 | 0.784 |
NDR1 |
0.788 | -0.037 | -3 | 0.822 |
RSK2 |
0.787 | 0.016 | -3 | 0.785 |
MARK4 |
0.787 | -0.029 | 4 | 0.837 |
DAPK2 |
0.787 | -0.003 | -3 | 0.865 |
PRKD2 |
0.786 | 0.013 | -3 | 0.775 |
IKKA |
0.786 | -0.073 | -2 | 0.832 |
CHAK2 |
0.786 | -0.066 | -1 | 0.846 |
GRK1 |
0.786 | -0.023 | -2 | 0.816 |
MLK3 |
0.786 | -0.019 | 2 | 0.745 |
NEK9 |
0.785 | -0.107 | 2 | 0.822 |
PKN2 |
0.785 | -0.045 | -3 | 0.831 |
PIM1 |
0.785 | 0.035 | -3 | 0.777 |
NIM1 |
0.785 | -0.034 | 3 | 0.806 |
BCKDK |
0.784 | -0.122 | -1 | 0.796 |
PKCA |
0.784 | 0.027 | 2 | 0.742 |
WNK3 |
0.784 | -0.155 | 1 | 0.313 |
IRE1 |
0.784 | -0.059 | 1 | 0.299 |
CAMK2D |
0.784 | -0.039 | -3 | 0.847 |
PINK1 |
0.784 | 0.184 | 1 | 0.501 |
MLK2 |
0.784 | -0.082 | 2 | 0.804 |
RSK3 |
0.783 | 0.000 | -3 | 0.781 |
ULK1 |
0.783 | -0.163 | -3 | 0.800 |
PHKG1 |
0.783 | -0.026 | -3 | 0.810 |
DNAPK |
0.782 | 0.009 | 1 | 0.316 |
MAPKAPK3 |
0.782 | -0.039 | -3 | 0.786 |
ANKRD3 |
0.782 | -0.109 | 1 | 0.343 |
HUNK |
0.782 | -0.132 | 2 | 0.755 |
TGFBR2 |
0.782 | -0.110 | -2 | 0.771 |
GRK5 |
0.781 | -0.161 | -3 | 0.831 |
LATS2 |
0.780 | -0.030 | -5 | 0.689 |
RIPK1 |
0.780 | -0.144 | 1 | 0.305 |
MASTL |
0.780 | -0.160 | -2 | 0.892 |
PKCB |
0.780 | 0.000 | 2 | 0.741 |
AMPKA1 |
0.780 | -0.064 | -3 | 0.837 |
PKCZ |
0.779 | -0.006 | 2 | 0.781 |
PKCG |
0.779 | -0.011 | 2 | 0.735 |
P70S6KB |
0.779 | -0.013 | -3 | 0.795 |
QIK |
0.779 | -0.052 | -3 | 0.839 |
MSK2 |
0.779 | 0.000 | -3 | 0.773 |
AURC |
0.778 | 0.031 | -2 | 0.692 |
QSK |
0.778 | -0.002 | 4 | 0.830 |
ATM |
0.777 | -0.068 | 1 | 0.296 |
PKACG |
0.777 | -0.028 | -2 | 0.779 |
PAK3 |
0.777 | -0.044 | -2 | 0.859 |
PKR |
0.776 | -0.043 | 1 | 0.333 |
VRK2 |
0.776 | 0.055 | 1 | 0.419 |
NEK2 |
0.776 | -0.072 | 2 | 0.804 |
PRKD3 |
0.776 | 0.000 | -3 | 0.773 |
AMPKA2 |
0.776 | -0.044 | -3 | 0.809 |
DLK |
0.776 | -0.198 | 1 | 0.334 |
SMG1 |
0.775 | -0.058 | 1 | 0.319 |
PAK6 |
0.775 | -0.000 | -2 | 0.797 |
MNK2 |
0.775 | -0.018 | -2 | 0.855 |
NUAK1 |
0.775 | -0.023 | -3 | 0.783 |
IRE2 |
0.775 | -0.075 | 2 | 0.751 |
YSK4 |
0.775 | -0.119 | 1 | 0.306 |
MPSK1 |
0.775 | 0.065 | 1 | 0.369 |
PAK1 |
0.774 | -0.030 | -2 | 0.852 |
SIK |
0.774 | -0.016 | -3 | 0.761 |
MLK4 |
0.774 | -0.076 | 2 | 0.732 |
MELK |
0.774 | -0.061 | -3 | 0.800 |
PKCH |
0.773 | -0.030 | 2 | 0.731 |
SGK3 |
0.773 | 0.017 | -3 | 0.779 |
MAPKAPK2 |
0.773 | -0.027 | -3 | 0.739 |
RSK4 |
0.772 | 0.014 | -3 | 0.747 |
GRK6 |
0.772 | -0.156 | 1 | 0.323 |
AKT2 |
0.771 | 0.044 | -3 | 0.709 |
PIM2 |
0.771 | 0.038 | -3 | 0.761 |
BMPR1B |
0.771 | -0.062 | 1 | 0.295 |
CHAK1 |
0.771 | -0.126 | 2 | 0.764 |
MEKK1 |
0.771 | -0.067 | 1 | 0.327 |
AURB |
0.770 | 0.010 | -2 | 0.699 |
BRSK2 |
0.770 | -0.065 | -3 | 0.811 |
TSSK2 |
0.770 | -0.106 | -5 | 0.737 |
PAK2 |
0.770 | -0.047 | -2 | 0.847 |
PKACB |
0.770 | 0.035 | -2 | 0.708 |
ALK4 |
0.770 | -0.085 | -2 | 0.827 |
TSSK1 |
0.770 | -0.076 | -3 | 0.849 |
MST3 |
0.769 | -0.006 | 2 | 0.807 |
MSK1 |
0.769 | 0.011 | -3 | 0.769 |
MEK1 |
0.769 | -0.138 | 2 | 0.796 |
PKCT |
0.769 | -0.010 | 2 | 0.738 |
LATS1 |
0.769 | -0.018 | -3 | 0.832 |
TTBK2 |
0.769 | -0.201 | 2 | 0.668 |
CAMK4 |
0.769 | -0.119 | -3 | 0.808 |
CAMK2A |
0.768 | -0.005 | 2 | 0.835 |
MNK1 |
0.768 | -0.024 | -2 | 0.857 |
PHKG2 |
0.768 | -0.045 | -3 | 0.788 |
GRK4 |
0.768 | -0.182 | -2 | 0.846 |
MARK3 |
0.768 | -0.024 | 4 | 0.790 |
ZAK |
0.768 | -0.108 | 1 | 0.313 |
BRSK1 |
0.767 | -0.052 | -3 | 0.791 |
WNK4 |
0.767 | -0.066 | -2 | 0.944 |
MAPKAPK5 |
0.767 | -0.060 | -3 | 0.752 |
MYLK4 |
0.767 | -0.016 | -2 | 0.826 |
MARK2 |
0.767 | -0.031 | 4 | 0.749 |
CAMK2B |
0.767 | -0.044 | 2 | 0.809 |
SNRK |
0.767 | -0.122 | 2 | 0.664 |
PKG2 |
0.767 | -0.006 | -2 | 0.704 |
GRK7 |
0.767 | -0.041 | 1 | 0.337 |
BRAF |
0.766 | -0.080 | -4 | 0.717 |
MEKK2 |
0.766 | -0.069 | 2 | 0.787 |
PKCI |
0.766 | 0.012 | 2 | 0.750 |
TGFBR1 |
0.766 | -0.074 | -2 | 0.788 |
IRAK4 |
0.766 | -0.085 | 1 | 0.283 |
AKT1 |
0.766 | 0.036 | -3 | 0.721 |
DRAK1 |
0.766 | -0.117 | 1 | 0.285 |
NEK5 |
0.765 | -0.081 | 1 | 0.308 |
MEK5 |
0.765 | -0.119 | 2 | 0.798 |
TAO3 |
0.764 | -0.024 | 1 | 0.346 |
GSK3A |
0.764 | 0.157 | 4 | 0.392 |
PLK4 |
0.764 | -0.114 | 2 | 0.590 |
PLK1 |
0.764 | -0.167 | -2 | 0.817 |
FAM20C |
0.764 | -0.035 | 2 | 0.596 |
MEKK3 |
0.763 | -0.141 | 1 | 0.329 |
PRKX |
0.763 | 0.044 | -3 | 0.673 |
CAMK1G |
0.762 | -0.044 | -3 | 0.771 |
PKCE |
0.762 | 0.026 | 2 | 0.726 |
PERK |
0.762 | -0.137 | -2 | 0.843 |
PDK1 |
0.762 | -0.019 | 1 | 0.349 |
AURA |
0.762 | -0.003 | -2 | 0.672 |
ACVR2B |
0.761 | -0.115 | -2 | 0.788 |
TLK2 |
0.761 | -0.141 | 1 | 0.293 |
ACVR2A |
0.761 | -0.119 | -2 | 0.775 |
DCAMKL1 |
0.761 | -0.047 | -3 | 0.772 |
MARK1 |
0.761 | -0.062 | 4 | 0.809 |
SMMLCK |
0.760 | -0.006 | -3 | 0.832 |
HRI |
0.760 | -0.158 | -2 | 0.869 |
NEK8 |
0.760 | -0.091 | 2 | 0.806 |
NEK11 |
0.759 | -0.096 | 1 | 0.343 |
PKN1 |
0.758 | 0.002 | -3 | 0.750 |
ALK2 |
0.758 | -0.100 | -2 | 0.796 |
CHK1 |
0.758 | -0.090 | -3 | 0.799 |
TAO2 |
0.757 | -0.034 | 2 | 0.836 |
NEK4 |
0.757 | -0.072 | 1 | 0.299 |
PAK5 |
0.757 | -0.021 | -2 | 0.734 |
GRK2 |
0.757 | -0.093 | -2 | 0.752 |
MAP3K15 |
0.757 | -0.052 | 1 | 0.320 |
P70S6K |
0.755 | -0.034 | -3 | 0.734 |
LKB1 |
0.755 | -0.038 | -3 | 0.816 |
PLK3 |
0.755 | -0.154 | 2 | 0.754 |
PKACA |
0.754 | 0.019 | -2 | 0.649 |
MEKK6 |
0.754 | -0.062 | 1 | 0.317 |
CAMKK1 |
0.754 | -0.132 | -2 | 0.851 |
HGK |
0.754 | -0.045 | 3 | 0.838 |
GCK |
0.753 | -0.052 | 1 | 0.336 |
PAK4 |
0.753 | -0.014 | -2 | 0.732 |
GAK |
0.753 | -0.037 | 1 | 0.374 |
HPK1 |
0.753 | -0.035 | 1 | 0.337 |
GSK3B |
0.753 | 0.022 | 4 | 0.385 |
CAMKK2 |
0.752 | -0.095 | -2 | 0.850 |
TTBK1 |
0.752 | -0.161 | 2 | 0.584 |
BUB1 |
0.752 | 0.037 | -5 | 0.707 |
IRAK1 |
0.751 | -0.180 | -1 | 0.776 |
DCAMKL2 |
0.751 | -0.073 | -3 | 0.797 |
PASK |
0.751 | -0.060 | -3 | 0.854 |
MINK |
0.751 | -0.078 | 1 | 0.310 |
TNIK |
0.751 | -0.030 | 3 | 0.829 |
CK1E |
0.751 | -0.057 | -3 | 0.519 |
NEK1 |
0.751 | -0.074 | 1 | 0.292 |
AKT3 |
0.751 | 0.035 | -3 | 0.658 |
BMPR1A |
0.750 | -0.091 | 1 | 0.280 |
KHS1 |
0.750 | -0.018 | 1 | 0.327 |
LRRK2 |
0.750 | -0.009 | 2 | 0.833 |
SSTK |
0.750 | -0.084 | 4 | 0.821 |
DAPK3 |
0.749 | -0.013 | -3 | 0.791 |
LOK |
0.749 | -0.049 | -2 | 0.847 |
TAK1 |
0.749 | -0.101 | 1 | 0.301 |
KHS2 |
0.749 | 0.002 | 1 | 0.340 |
SBK |
0.749 | 0.116 | -3 | 0.602 |
SGK1 |
0.748 | 0.048 | -3 | 0.640 |
CHK2 |
0.747 | -0.001 | -3 | 0.662 |
RIPK2 |
0.747 | -0.147 | 1 | 0.290 |
YSK1 |
0.747 | -0.051 | 2 | 0.801 |
MST2 |
0.747 | -0.127 | 1 | 0.320 |
CK1D |
0.747 | -0.033 | -3 | 0.473 |
CK1G1 |
0.746 | -0.083 | -3 | 0.503 |
PBK |
0.746 | -0.023 | 1 | 0.338 |
TLK1 |
0.746 | -0.188 | -2 | 0.819 |
MRCKB |
0.746 | 0.015 | -3 | 0.746 |
CAMK1D |
0.745 | -0.038 | -3 | 0.702 |
ROCK2 |
0.745 | 0.012 | -3 | 0.782 |
NEK3 |
0.745 | -0.056 | 1 | 0.309 |
HASPIN |
0.744 | 0.021 | -1 | 0.709 |
SLK |
0.743 | -0.058 | -2 | 0.790 |
EEF2K |
0.743 | -0.092 | 3 | 0.789 |
CK1A2 |
0.742 | -0.055 | -3 | 0.475 |
DAPK1 |
0.742 | -0.022 | -3 | 0.783 |
VRK1 |
0.741 | -0.133 | 2 | 0.789 |
MRCKA |
0.741 | -0.007 | -3 | 0.755 |
CAMK1A |
0.740 | -0.013 | -3 | 0.680 |
BIKE |
0.740 | 0.004 | 1 | 0.349 |
MEK2 |
0.740 | -0.152 | 2 | 0.772 |
STK33 |
0.740 | -0.129 | 2 | 0.588 |
ASK1 |
0.739 | -0.044 | 1 | 0.318 |
GRK3 |
0.739 | -0.105 | -2 | 0.697 |
PDHK3_TYR |
0.738 | 0.145 | 4 | 0.856 |
DMPK1 |
0.738 | 0.045 | -3 | 0.759 |
MST1 |
0.737 | -0.151 | 1 | 0.311 |
CK2A2 |
0.736 | -0.083 | 1 | 0.260 |
PKMYT1_TYR |
0.736 | 0.155 | 3 | 0.871 |
MYO3B |
0.735 | -0.024 | 2 | 0.811 |
TAO1 |
0.734 | -0.049 | 1 | 0.305 |
ROCK1 |
0.733 | 0.006 | -3 | 0.751 |
LIMK2_TYR |
0.733 | 0.116 | -3 | 0.874 |
AAK1 |
0.732 | 0.034 | 1 | 0.332 |
OSR1 |
0.731 | -0.082 | 2 | 0.773 |
MAP2K4_TYR |
0.731 | 0.037 | -1 | 0.875 |
TESK1_TYR |
0.731 | 0.027 | 3 | 0.864 |
PDHK4_TYR |
0.731 | 0.065 | 2 | 0.867 |
MYO3A |
0.731 | -0.056 | 1 | 0.320 |
PKG1 |
0.731 | -0.023 | -2 | 0.620 |
CRIK |
0.730 | 0.009 | -3 | 0.731 |
CK2A1 |
0.730 | -0.086 | 1 | 0.251 |
TTK |
0.728 | -0.076 | -2 | 0.810 |
MAP2K7_TYR |
0.728 | -0.044 | 2 | 0.840 |
MAP2K6_TYR |
0.727 | 0.018 | -1 | 0.877 |
JAK2 |
0.727 | -0.039 | 1 | 0.342 |
PLK2 |
0.726 | -0.118 | -3 | 0.736 |
PINK1_TYR |
0.726 | -0.092 | 1 | 0.367 |
TYK2 |
0.725 | -0.102 | 1 | 0.325 |
JAK1 |
0.725 | -0.002 | 1 | 0.315 |
MST1R |
0.725 | -0.037 | 3 | 0.865 |
BMPR2_TYR |
0.725 | -0.003 | -1 | 0.857 |
RET |
0.724 | -0.092 | 1 | 0.338 |
LIMK1_TYR |
0.724 | 0.010 | 2 | 0.833 |
CSF1R |
0.723 | -0.034 | 3 | 0.857 |
PDHK1_TYR |
0.723 | -0.056 | -1 | 0.876 |
ROS1 |
0.723 | -0.064 | 3 | 0.841 |
TNNI3K_TYR |
0.722 | 0.031 | 1 | 0.349 |
ABL2 |
0.719 | -0.066 | -1 | 0.796 |
NEK10_TYR |
0.719 | -0.057 | 1 | 0.288 |
TYRO3 |
0.719 | -0.107 | 3 | 0.848 |
YES1 |
0.718 | -0.052 | -1 | 0.846 |
EPHB4 |
0.717 | -0.099 | -1 | 0.824 |
JAK3 |
0.717 | -0.085 | 1 | 0.324 |
ABL1 |
0.716 | -0.070 | -1 | 0.792 |
TNK1 |
0.716 | -0.023 | 3 | 0.838 |
KDR |
0.716 | -0.029 | 3 | 0.833 |
EPHA6 |
0.716 | -0.092 | -1 | 0.835 |
HCK |
0.715 | -0.076 | -1 | 0.819 |
LCK |
0.715 | -0.050 | -1 | 0.816 |
YANK3 |
0.715 | -0.079 | 2 | 0.370 |
BLK |
0.714 | -0.028 | -1 | 0.823 |
FGR |
0.714 | -0.118 | 1 | 0.315 |
STLK3 |
0.714 | -0.167 | 1 | 0.291 |
TNK2 |
0.713 | -0.068 | 3 | 0.831 |
TXK |
0.713 | -0.065 | 1 | 0.299 |
FGFR2 |
0.713 | -0.032 | 3 | 0.834 |
KIT |
0.712 | -0.085 | 3 | 0.851 |
FLT3 |
0.711 | -0.117 | 3 | 0.848 |
TEK |
0.711 | -0.005 | 3 | 0.804 |
FGFR1 |
0.711 | -0.029 | 3 | 0.828 |
PDGFRB |
0.710 | -0.144 | 3 | 0.861 |
WEE1_TYR |
0.709 | -0.047 | -1 | 0.744 |
ALPHAK3 |
0.709 | -0.130 | -1 | 0.763 |
DDR1 |
0.708 | -0.147 | 4 | 0.772 |
FER |
0.707 | -0.175 | 1 | 0.317 |
INSRR |
0.707 | -0.127 | 3 | 0.806 |
CK1A |
0.707 | -0.077 | -3 | 0.379 |
EPHB1 |
0.706 | -0.146 | 1 | 0.302 |
SRMS |
0.706 | -0.145 | 1 | 0.299 |
MERTK |
0.706 | -0.106 | 3 | 0.839 |
AXL |
0.706 | -0.120 | 3 | 0.839 |
ITK |
0.706 | -0.131 | -1 | 0.796 |
MET |
0.705 | -0.096 | 3 | 0.847 |
PDGFRA |
0.705 | -0.156 | 3 | 0.866 |
EPHA4 |
0.705 | -0.100 | 2 | 0.747 |
EPHB3 |
0.705 | -0.142 | -1 | 0.808 |
FYN |
0.704 | -0.057 | -1 | 0.793 |
ALK |
0.703 | -0.118 | 3 | 0.803 |
EPHB2 |
0.703 | -0.140 | -1 | 0.796 |
EPHA1 |
0.702 | -0.099 | 3 | 0.836 |
FGFR3 |
0.701 | -0.058 | 3 | 0.810 |
LTK |
0.701 | -0.121 | 3 | 0.823 |
EPHA7 |
0.701 | -0.101 | 2 | 0.752 |
BTK |
0.701 | -0.175 | -1 | 0.759 |
DDR2 |
0.701 | -0.023 | 3 | 0.804 |
LYN |
0.701 | -0.088 | 3 | 0.810 |
FLT1 |
0.701 | -0.107 | -1 | 0.796 |
ERBB2 |
0.700 | -0.133 | 1 | 0.317 |
BMX |
0.700 | -0.106 | -1 | 0.714 |
TEC |
0.700 | -0.116 | -1 | 0.735 |
FRK |
0.699 | -0.120 | -1 | 0.814 |
FLT4 |
0.698 | -0.119 | 3 | 0.823 |
NTRK2 |
0.698 | -0.164 | 3 | 0.828 |
SRC |
0.697 | -0.083 | -1 | 0.799 |
NTRK3 |
0.697 | -0.121 | -1 | 0.749 |
NTRK1 |
0.697 | -0.186 | -1 | 0.794 |
INSR |
0.696 | -0.139 | 3 | 0.791 |
EPHA3 |
0.695 | -0.131 | 2 | 0.730 |
PTK6 |
0.694 | -0.188 | -1 | 0.736 |
PTK2B |
0.694 | -0.101 | -1 | 0.780 |
EGFR |
0.693 | -0.099 | 1 | 0.279 |
EPHA8 |
0.693 | -0.102 | -1 | 0.790 |
MATK |
0.692 | -0.096 | -1 | 0.716 |
MUSK |
0.690 | -0.113 | 1 | 0.267 |
FGFR4 |
0.690 | -0.094 | -1 | 0.749 |
CSK |
0.689 | -0.135 | 2 | 0.748 |
EPHA5 |
0.689 | -0.131 | 2 | 0.740 |
CK1G3 |
0.687 | -0.076 | -3 | 0.333 |
EPHA2 |
0.683 | -0.111 | -1 | 0.746 |
YANK2 |
0.683 | -0.096 | 2 | 0.391 |
PTK2 |
0.683 | -0.076 | -1 | 0.758 |
ERBB4 |
0.681 | -0.086 | 1 | 0.286 |
SYK |
0.679 | -0.103 | -1 | 0.738 |
IGF1R |
0.678 | -0.145 | 3 | 0.739 |
ZAP70 |
0.672 | -0.062 | -1 | 0.680 |
FES |
0.670 | -0.132 | -1 | 0.695 |
CK1G2 |
0.662 | -0.091 | -3 | 0.422 |