Motif 708 (n=161)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2193 | ochoa | Snf2 related CREBBP activator protein | None |
| F8WAN1 | SPECC1L-ADORA2A | S171 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| O00170 | AIP | S53 | psp | AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) | May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein. |
| O00411 | POLRMT | S1184 | ochoa | DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6) | DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924). {ECO:0000269|PubMed:18685103, ECO:0000269|PubMed:21278163, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:33602924}. |
| O00418 | EEF2K | S243 | ochoa | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O14523 | C2CD2L | S623 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O14777 | NDC80 | S76 | ochoa|psp | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}. |
| O15042 | U2SURP | S747 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15381 | NVL | S185 | ochoa | Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) | Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}. |
| O43399 | TPD52L2 | S141 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43741 | PRKAB2 | S39 | ochoa | 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| O43815 | STRN | S204 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60237 | PPP1R12B | S789 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O60503 | ADCY9 | S357 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60832 | DKC1 | S387 | ochoa | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}. |
| O60934 | NBN | S410 | ochoa | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75363 | BCAS1 | S234 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O94921 | CDK14 | Y146 | ochoa | Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1) | Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}. |
| O95251 | KAT7 | S216 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| O95671 | ASMTL | S246 | ochoa | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}. |
| P00367 | GLUD1 | S384 | psp | Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) | Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:11254391, PubMed:16023112, PubMed:16959573). Plays a role in insulin homeostasis (PubMed:11297618, PubMed:9571255). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). {ECO:0000250|UniProtKB:P10860, ECO:0000269|PubMed:11032875, ECO:0000269|PubMed:11254391, ECO:0000269|PubMed:11297618, ECO:0000269|PubMed:16023112, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:9571255}. |
| P04350 | TUBB4A | S335 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P06732 | CKM | S128 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
| P07737 | PFN1 | S57 | ochoa | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}. |
| P10451 | SPP1 | S228 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10636 | MAPT | S400 | psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P10721 | KIT | S821 | psp | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| P11831 | SRF | S251 | psp | Serum response factor (SRF) | SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}. |
| P12532 | CKMT1A | S318 | ochoa | Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P13807 | GYS1 | S288 | ochoa | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}. |
| P14618 | PKM | S420 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P15927 | RPA2 | S72 | psp | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P17540 | CKMT2 | S162 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P18031 | PTPN1 | S242 | psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P18206 | VCL | S755 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P20929 | NEB | S925 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P27797 | CALR | S193 | ochoa | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| P28223 | HTR2A | S280 | psp | 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) | G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895, PubMed:21645528, PubMed:22300836, PubMed:35084960, PubMed:38552625). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538, PubMed:35084960). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:28129538, PubMed:35084960). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed:18703043, PubMed:28129538, PubMed:35084960). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538, PubMed:35084960). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity). {ECO:0000250|UniProtKB:P35363, ECO:0000269|PubMed:1330647, ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:21645528, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:35084960, ECO:0000269|PubMed:38552625}.; FUNCTION: (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. {ECO:0000269|PubMed:24089568}. |
| P29317 | EPHA2 | S775 | ochoa | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
| P29323 | EPHB2 | S782 | ochoa | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| P32298 | GRK4 | S244 | psp | G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}. |
| P34910 | EVI2B | S263 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P35613 | BSG | S362 | ochoa | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. |
| P35637 | FUS | S282 | ochoa | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P38935 | IGHMBP2 | S652 | ochoa | DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) | 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:19158098, PubMed:22999958, PubMed:30218034). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:22999958, PubMed:8349627). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). {ECO:0000250|UniProtKB:Q9EQN5, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493, ECO:0000269|PubMed:22999958, ECO:0000269|PubMed:30218034, ECO:0000269|PubMed:8349627}. |
| P40925 | MDH1 | S188 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P42575 | CASP2 | S164 | ochoa|psp | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). {ECO:0000269|PubMed:11156409, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 1]: Acts as a positive regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 2]: Acts as a negative regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. {ECO:0000269|PubMed:11156409}. |
| P46821 | MAP1B | S1764 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49005 | POLD2 | S254 | ochoa | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:12403614, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906}. |
| P49790 | NUP153 | S1115 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P52179 | MYOM1 | S1493 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54753 | EPHB3 | S794 | ochoa | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. {ECO:0000269|PubMed:15536074}. |
| P56524 | HDAC4 | S246 | ochoa|psp | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P56589 | PEX3 | S311 | ochoa | Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3) | Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes. {ECO:0000269|PubMed:10848631, ECO:0000269|PubMed:15007061}. |
| P61353 | RPL27 | S39 | ochoa | Large ribosomal subunit protein eL27 (60S ribosomal protein L27) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P62854 | RPS26 | S57 | ochoa | Small ribosomal subunit protein eS26 (40S ribosomal protein S26) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688}. |
| Q00169 | PITPNA | S165 | psp | Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha) | Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:10531358, PubMed:14962392, PubMed:15522822, PubMed:18636990, PubMed:22822086). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (PubMed:15522822, PubMed:22822086). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:14962392, ECO:0000269|PubMed:15522822, ECO:0000269|PubMed:18636990, ECO:0000269|PubMed:22822086}. |
| Q00653 | NFKB2 | S99 | psp | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q00688 | FKBP3 | S152 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| Q03188 | CENPC | S52 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q09666 | AHNAK | S845 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13501 | SQSTM1 | S152 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13813 | SPTAN1 | S1557 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14168 | MPP2 | S338 | ochoa | MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2) | Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017). {ECO:0000250|UniProtKB:D3ZAA9, ECO:0000250|UniProtKB:Q9WV34, ECO:0000269|PubMed:19665017}. |
| Q14590 | ZNF235 | S122 | ochoa | Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) | May be involved in transcriptional regulation. |
| Q14766 | LTBP1 | S438 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q15149 | PLEC | S584 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15149 | PLEC | S2833 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15185 | PTGES3 | S82 | ochoa | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Q15326 | ZMYND11 | S383 | ochoa | Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69) | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250|UniProtKB:Q8R5C8, ECO:0000269|PubMed:10734313, ECO:0000269|PubMed:16565076, ECO:0000269|PubMed:24675531}.; FUNCTION: (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. {ECO:0000269|PubMed:26845565}. |
| Q15910 | EZH2 | S406 | ochoa | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:30923826}. |
| Q16531 | DDB1 | S661 | ochoa | DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) | Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:14739464, PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16407252, PubMed:16482215, PubMed:16940174, PubMed:17079684). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:15448697, PubMed:16260596, PubMed:16407242, PubMed:16940174). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355, PubMed:28886238). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (PubMed:14739464, PubMed:16407252, PubMed:16482215, PubMed:17079684, PubMed:18332868, PubMed:18381890, PubMed:19966799, PubMed:22118460, PubMed:25043012, PubMed:25108355). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16473935, PubMed:16678110, PubMed:17041588, PubMed:18593899). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:17041588). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:12732143, PubMed:32355176, PubMed:38316879). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). Maternal factor required for proper zygotic genome activation and genome reprogramming (By similarity). {ECO:0000250|UniProtKB:Q3U1J4, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242, ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:38316879}. |
| Q29RF7 | PDS5A | S1206 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q4VCS5 | AMOT | S538 | psp | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q5JSH3 | WDR44 | S411 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5JSL3 | DOCK11 | S158 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
| Q5JSL3 | DOCK11 | S161 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
| Q5SW79 | CEP170 | S1362 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T4S7 | UBR4 | S2743 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5THJ4 | VPS13D | S1600 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5UIP0 | RIF1 | S1608 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q641Q2 | WASHC2A | S552 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q69YH5 | CDCA2 | S24 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q69YQ0 | SPECC1L | S171 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6FIF0 | ZFAND6 | S182 | ochoa | AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3) | Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19285159, ECO:0000269|PubMed:21810480}. |
| Q6ISB3 | GRHL2 | S214 | ochoa | Grainyhead-like protein 2 homolog (Brother of mammalian grainyhead) (Transcription factor CP2-like 3) | Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456, PubMed:29309642). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293). {ECO:0000250|UniProtKB:Q8K5C0, ECO:0000269|PubMed:19015635, ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:23254293, ECO:0000269|PubMed:25152456, ECO:0000269|PubMed:29309642, ECO:0000305|PubMed:12175488}. |
| Q6P9A1 | ZNF530 | S131 | ochoa | Zinc finger protein 530 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6PL18 | ATAD2 | S162 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6XZF7 | DNMBP | S996 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZMW3 | EML6 | S1296 | ochoa | Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) | May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. {ECO:0000250}. |
| Q6ZRS2 | SRCAP | S2370 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q86SF2 | GALNT7 | S103 | ochoa | N-acetylgalactosaminyltransferase 7 (EC 2.4.1.41) (Polypeptide GalNAc transferase 7) (GalNAc-T7) (pp-GaNTase 7) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7) | Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. {ECO:0000269|PubMed:10544240, ECO:0000269|PubMed:11925450}. |
| Q86UE4 | MTDH | S478 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q8IUI4 | SNX29P2 | S209 | ochoa | Putative protein SNX29P2 (RUN domain-containing protein 2C) (Sorting nexin 29 protein pseudogene 2) | None |
| Q8IV36 | HID1 | S616 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8N9T8 | KRI1 | S182 | ochoa | Protein KRI1 homolog | None |
| Q8NEM0 | MCPH1 | S101 | ochoa | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
| Q8NFC6 | BOD1L1 | S980 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFP9 | NBEA | S1731 | ochoa | Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}. |
| Q8TC76 | FAM110B | S200 | ochoa | Protein FAM110B | May be involved in tumor progression. |
| Q8TD55 | PLEKHO2 | S256 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TEQ0 | SNX29 | S362 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8WW12 | PCNP | S147 | ochoa | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | May be involved in cell cycle regulation. |
| Q92541 | RTF1 | S677 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q92585 | MAML1 | S286 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92608 | DOCK2 | S1731 | ochoa | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q969I6 | SLC38A4 | S22 | ochoa | Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3) | Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:11342143, PubMed:19015196, PubMed:33928121). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11414754). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (PubMed:11414754, PubMed:33928121). {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:19015196, ECO:0000269|PubMed:33928121}. |
| Q96EA4 | SPDL1 | S471 | ochoa | Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1) | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100). {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:30258100}. |
| Q96F24 | NRBF2 | S105 | ochoa | Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR) | May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). {ECO:0000269|PubMed:15610520}.; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VCQ3, ECO:0000269|PubMed:24785657, ECO:0000269|PubMed:25086043}. |
| Q96JE7 | SEC16B | S173 | ochoa | Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) | Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:21768384, PubMed:22355596). Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes (PubMed:21768384). {ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:21768384, ECO:0000303|PubMed:22355596}. |
| Q96K49 | TMEM87B | S480 | ochoa | Transmembrane protein 87B | May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. |
| Q96QT4 | TRPM7 | S103 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96T88 | UHRF1 | S368 | ochoa | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q99700 | ATXN2 | S356 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BQ70 | TCF25 | S81 | ochoa | Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25) | Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (By similarity). {ECO:0000250|UniProtKB:A0A8I6ASZ5, ECO:0000250|UniProtKB:Q8R3L2, ECO:0000269|PubMed:30244831}. |
| Q9BW04 | SARG | S555 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BYG3 | NIFK | S145 | ochoa | MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK) | None |
| Q9C0D5 | TANC1 | S609 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H792 | PEAK1 | S1108 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9NPG4 | PCDH12 | S906 | ochoa | Protocadherin-12 (Vascular cadherin-2) (Vascular endothelial cadherin-2) (VE-cad-2) (VE-cadherin-2) [Cleaved into: Protocadherin-12, secreted form] | Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). {ECO:0000250|UniProtKB:O55134, ECO:0000269|PubMed:21402705}. |
| Q9NRL3 | STRN4 | S284 | ochoa | Striatin-4 (Zinedin) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:32640226, ECO:0000305|PubMed:26876214}. |
| Q9P260 | RELCH | S419 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9P275 | USP36 | S651 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9UHF7 | TRPS1 | S391 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UKV0 | HDAC9 | S220 | ochoa|psp | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Q9UKX7 | NUP50 | S262 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9ULD4 | BRPF3 | S76 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9UNF1 | MAGED2 | S194 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UQL6 | HDAC5 | S259 | ochoa|psp | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}. |
| Q9Y3M8 | STARD13 | S389 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y446 | PKP3 | S698 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y487 | ATP6V0A2 | S159 | ochoa | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (PubMed:18157129). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:16415858, ECO:0000269|PubMed:18157129, ECO:0000269|PubMed:28296633}. |
| Q9Y4C1 | KDM3A | S766 | ochoa | Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}. |
| Q9Y617 | PSAT1 | S38 | ochoa | Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) | Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}. |
| Q9Y6R4 | MAP3K4 | S164 | ochoa | Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) | Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}. |
| P12277 | CKB | S128 | Sugiyama | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| P27797 | CALR | S35 | Sugiyama | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| P48739 | PITPNB | S165 | Sugiyama | Phosphatidylinositol transfer protein beta isoform (PI-TP-beta) (PtdIns transfer protein beta) (PtdInsTP beta) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed:10531358, PubMed:18636990, PubMed:20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed:20332109). {ECO:0000250|UniProtKB:Q9TR36, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:18636990, ECO:0000269|PubMed:20332109}. |
| Q14320 | FAM50A | S292 | Sugiyama | Protein FAM50A (Protein HXC-26) (Protein XAP-5) | Probably involved in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:32703943}. |
| Q9Y2B0 | CNPY2 | S153 | Sugiyama | Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) | Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
| O15111 | CHUK | S126 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| O60828 | PQBP1 | S210 | Sugiyama | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:21933836, ECO:0000269|PubMed:23512658, ECO:0000269|PubMed:26046437}. |
| Q99798 | ACO2 | S388 | Sugiyama | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
| P07333 | CSF1R | S807 | Sugiyama | Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) | Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (PubMed:20504948, PubMed:30982609). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages (PubMed:30982608). {ECO:0000269|PubMed:12882960, ECO:0000269|PubMed:15117969, ECO:0000269|PubMed:16170366, ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:16648572, ECO:0000269|PubMed:17121910, ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:18814279, ECO:0000269|PubMed:19193011, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061, ECO:0000269|PubMed:30982608, ECO:0000269|PubMed:30982609, ECO:0000269|PubMed:7683918}. |
| P16234 | PDGFRA | S847 | Sugiyama | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| P02786 | TFRC | S361 | Sugiyama | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity). {ECO:0000250|UniProtKB:Q62351, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.; FUNCTION: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762, ECO:0000269|PubMed:36779763}.; FUNCTION: (Microbial infection) Acts as a host entry factor for SARS-CoV, MERS-CoV and SARS-CoV-2 viruses that hijack the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762}. |
| Q96PH1 | NOX5 | S544 | SIGNOR | NADPH oxidase 5 (EC 1.6.3.-) | Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:12686516). May play a role in cell growth and apoptosis (PubMed:12686516). {ECO:0000269|PubMed:12686516}.; FUNCTION: [Isoform v2]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:11483596, PubMed:14982937, PubMed:17275676, PubMed:17587483, PubMed:21642394, PubMed:22387196, PubMed:22427510, PubMed:24505490, PubMed:36653838). Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contributes to endothelial response to thrombin (PubMed:17275676). Regulates redox-dependent processes in lymphocytes and spermatozoa (PubMed:11483596). {ECO:0000269|PubMed:11483596, ECO:0000269|PubMed:14982937, ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:17587483, ECO:0000269|PubMed:21642394, ECO:0000269|PubMed:22387196, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:24505490, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v1]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269|PubMed:21319793, ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v5]: This isoform lacks calcium-binding domains and was showed to present a NADPH oxidase activity in a calcium-independent manner (PubMed:17275676, PubMed:36653838). May be involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin (PubMed:17275676). However another study showed an absence of oxidase activity (PubMed:22427510). Subject to rapid degradation (PubMed:36653838). {ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v3]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v4]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}. |
| P36888 | FLT3 | S840 | Sugiyama | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}. |
| P22234 | PAICS | S213 | Sugiyama | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P26232 | CTNNA2 | S667 | Sugiyama | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P35221 | CTNNA1 | S668 | Sugiyama | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| Q02156 | PRKCE | S238 | Sugiyama | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q15165 | PON2 | S300 | Sugiyama | Serum paraoxonase/arylesterase 2 (PON 2) (EC 3.1.1.2) (EC 3.1.1.81) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2) | Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. {ECO:0000269|PubMed:11579088, ECO:0000269|PubMed:15772423}. |
| P42224 | STAT1 | S132 | Sugiyama | Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) | Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:12764129, PubMed:12855578, PubMed:15322115, PubMed:23940278, PubMed:34508746, PubMed:35568036, PubMed:9724754). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426, PubMed:35568036). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state (PubMed:28753426, PubMed:35568036). In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state (PubMed:8156998). Becomes activated in response to KITLG/SCF and KIT signaling (PubMed:15526160). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:19088846). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylated at Thr-749 by IKBKB which promotes binding of STAT1 to the 5'-TTTGAGGC-3' sequence in the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). Phosphorylation at Thr-749 also promotes binding of STAT1 to the 5'-TTTGAGTC-3' sequence in the IL12B promoter and activation of IL12B transcription (PubMed:32209697). Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine (By similarity). {ECO:0000250|UniProtKB:P42225, ECO:0000269|PubMed:12764129, ECO:0000269|PubMed:12855578, ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:23940278, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:34508746, ECO:0000269|PubMed:35568036, ECO:0000269|PubMed:8156998, ECO:0000269|PubMed:9724754, ECO:0000303|PubMed:15526160}. |
| Q8IY84 | NIM1K | S86 | Sugiyama | Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) | None |
| Q14683 | SMC1A | S649 | Sugiyama | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}. |
| P05388 | RPLP0 | S37 | Sugiyama | Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. |
| Q8NHW5 | RPLP0P6 | S37 | Sugiyama | Putative ribosomal protein uL10-like (60S acidic ribosomal protein P0-like) (Large ribosomal subunit protein uL10-like) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. {ECO:0000250}. |
| Q9P2K8 | EIF2AK4 | S1049 | Sugiyama | eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}. |
| Q9NUU7 | DDX19A | S59 | Sugiyama | ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DDX19-like protein) (DEAD box protein 19A) | ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. {ECO:0000250|UniProtKB:Q9UMR2}. |
| Q9UMR2 | DDX19B | S60 | Sugiyama | ATP-dependent RNA helicase DDX19B (EC 3.6.4.13) (DEAD box RNA helicase DEAD5) (DEAD box protein 19B) | ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). {ECO:0000269|PubMed:10428971}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-71288 | Creatine metabolism | 0.000229 | 3.641 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.000149 | 3.827 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.000236 | 3.627 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.000350 | 3.456 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.000401 | 3.397 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.000494 | 3.306 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.000589 | 3.230 |
| R-HSA-9702506 | Drug resistance of FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 0.011546 | 1.938 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 0.011546 | 1.938 |
| R-HSA-9669921 | KIT mutants bind TKIs | 0.011546 | 1.938 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 0.011546 | 1.938 |
| R-HSA-9702509 | FLT3 mutants bind TKIs | 0.011546 | 1.938 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 0.011546 | 1.938 |
| R-HSA-9702636 | tandutinib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9702632 | sunitinib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9702569 | KW2449-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9702581 | crenolanib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9702624 | sorafenib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9702620 | quizartinib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9702590 | gilteritinib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9702600 | midostaurin-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9702614 | ponatinib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9702998 | linifanib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 0.011546 | 1.938 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9702605 | pexidartinib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 0.011546 | 1.938 |
| R-HSA-9702577 | semaxanib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9702596 | lestaurtinib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9703009 | tamatinib-resistant FLT3 mutants | 0.011546 | 1.938 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 0.011546 | 1.938 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.004038 | 2.394 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.006214 | 2.207 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.010266 | 1.989 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.004443 | 2.352 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.004443 | 2.352 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.007563 | 2.121 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.004018 | 2.396 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.005374 | 2.270 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.005255 | 2.279 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.004038 | 2.394 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.008516 | 2.070 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.008516 | 2.070 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.008516 | 2.070 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.008516 | 2.070 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.010266 | 1.989 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.004443 | 2.352 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.003186 | 2.497 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.001563 | 2.806 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.008516 | 2.070 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.011324 | 1.946 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.004228 | 2.374 |
| R-HSA-1640170 | Cell Cycle | 0.005220 | 2.282 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.006214 | 2.207 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.011525 | 1.938 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.003790 | 2.421 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.003781 | 2.422 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.001989 | 2.701 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.011520 | 1.939 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.004658 | 2.332 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.010210 | 1.991 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.010291 | 1.988 |
| R-HSA-74160 | Gene expression (Transcription) | 0.008010 | 2.096 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.012505 | 1.903 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.013183 | 1.880 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.013183 | 1.880 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.013463 | 1.871 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.013463 | 1.871 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.015203 | 1.818 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.017034 | 1.769 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.017034 | 1.769 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.015894 | 1.799 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.018953 | 1.722 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.020959 | 1.679 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.020959 | 1.679 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.020959 | 1.679 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.020959 | 1.679 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.020325 | 1.692 |
| R-HSA-9833482 | PKR-mediated signaling | 0.020015 | 1.699 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.019664 | 1.706 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.022140 | 1.655 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.023274 | 1.633 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.027474 | 1.561 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.026860 | 1.571 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.027474 | 1.561 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.027474 | 1.561 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.026745 | 1.573 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.024438 | 1.612 |
| R-HSA-75153 | Apoptotic execution phase | 0.025634 | 1.591 |
| R-HSA-212436 | Generic Transcription Pathway | 0.025952 | 1.586 |
| R-HSA-168255 | Influenza Infection | 0.029045 | 1.537 |
| R-HSA-73893 | DNA Damage Bypass | 0.029406 | 1.532 |
| R-HSA-1483196 | PI and PC transport between ER and Golgi membranes | 0.034241 | 1.465 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 0.034241 | 1.465 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 0.034241 | 1.465 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.034241 | 1.465 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.034241 | 1.465 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 0.034241 | 1.465 |
| R-HSA-3928664 | Ephrin signaling | 0.029804 | 1.526 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.029804 | 1.526 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.039280 | 1.406 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.037240 | 1.429 |
| R-HSA-68877 | Mitotic Prometaphase | 0.038446 | 1.415 |
| R-HSA-163282 | Mitochondrial transcription initiation | 0.034241 | 1.465 |
| R-HSA-163615 | PKA activation | 0.029804 | 1.526 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.033934 | 1.469 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.037240 | 1.429 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.029804 | 1.526 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.030370 | 1.518 |
| R-HSA-5358508 | Mismatch Repair | 0.029804 | 1.526 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.038109 | 1.419 |
| R-HSA-162582 | Signal Transduction | 0.032793 | 1.484 |
| R-HSA-449147 | Signaling by Interleukins | 0.039406 | 1.404 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.039861 | 1.399 |
| R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 0.045394 | 1.343 |
| R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 0.045394 | 1.343 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.056419 | 1.249 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.067317 | 1.172 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.078089 | 1.107 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.088738 | 1.052 |
| R-HSA-9645135 | STAT5 Activation | 0.099265 | 1.003 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 0.099265 | 1.003 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.119956 | 0.921 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 0.119956 | 0.921 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.130124 | 0.886 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.159932 | 0.796 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.169640 | 0.770 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.169640 | 0.770 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.056945 | 1.245 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.179237 | 0.747 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.179237 | 0.747 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.063113 | 1.200 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.066279 | 1.179 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.188723 | 0.724 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.069496 | 1.158 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.069496 | 1.158 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.198101 | 0.703 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.076080 | 1.119 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.076080 | 1.119 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.079444 | 1.100 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.207370 | 0.683 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.207370 | 0.683 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.082853 | 1.082 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.086307 | 1.064 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.216533 | 0.664 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.042373 | 1.373 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.100534 | 0.998 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.104187 | 0.982 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.097364 | 1.012 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.097364 | 1.012 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.111672 | 0.952 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.114131 | 0.943 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.124171 | 0.906 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.126729 | 0.897 |
| R-HSA-192823 | Viral mRNA Translation | 0.147853 | 0.830 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.161597 | 0.792 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.164392 | 0.784 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.236026 | 0.627 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.066279 | 1.179 |
| R-HSA-186763 | Downstream signal transduction | 0.069496 | 1.158 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.063113 | 1.200 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.126812 | 0.897 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.116611 | 0.933 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.107875 | 0.967 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.092773 | 1.033 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.107769 | 0.968 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.156053 | 0.807 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.207370 | 0.683 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.175710 | 0.755 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.073300 | 1.135 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.198101 | 0.703 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.234544 | 0.630 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.104187 | 0.982 |
| R-HSA-156902 | Peptide chain elongation | 0.104420 | 0.981 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.175710 | 0.755 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.159932 | 0.796 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.107875 | 0.967 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.122963 | 0.910 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.126729 | 0.897 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.130124 | 0.886 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.048123 | 1.318 |
| R-HSA-1500620 | Meiosis | 0.095057 | 1.022 |
| R-HSA-5693538 | Homology Directed Repair | 0.198961 | 0.701 |
| R-HSA-186797 | Signaling by PDGF | 0.048915 | 1.311 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.086307 | 1.064 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.221043 | 0.656 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.169640 | 0.770 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.134593 | 0.871 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.181450 | 0.741 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.139345 | 0.856 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.136856 | 0.864 |
| R-HSA-8849472 | PTK6 Down-Regulation | 0.078089 | 1.107 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.076080 | 1.119 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.164392 | 0.784 |
| R-HSA-180786 | Extension of Telomeres | 0.043965 | 1.357 |
| R-HSA-912446 | Meiotic recombination | 0.150460 | 0.823 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.126729 | 0.897 |
| R-HSA-525793 | Myogenesis | 0.053945 | 1.268 |
| R-HSA-3371511 | HSF1 activation | 0.089803 | 1.047 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.139800 | 0.854 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.193078 | 0.714 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.166675 | 0.778 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.082853 | 1.082 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.193078 | 0.714 |
| R-HSA-73886 | Chromosome Maintenance | 0.073619 | 1.133 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.207370 | 0.683 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.057741 | 1.239 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.140175 | 0.853 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.159932 | 0.796 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.169640 | 0.770 |
| R-HSA-77387 | Insulin receptor recycling | 0.060002 | 1.222 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.082853 | 1.082 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.082853 | 1.082 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.093340 | 1.030 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.225591 | 0.647 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.234544 | 0.630 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.111599 | 0.952 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.126812 | 0.897 |
| R-HSA-157579 | Telomere Maintenance | 0.131903 | 0.880 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.064639 | 1.190 |
| R-HSA-69190 | DNA strand elongation | 0.072764 | 1.138 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.119956 | 0.921 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.169640 | 0.770 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.198101 | 0.703 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.169640 | 0.770 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.116611 | 0.933 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.174894 | 0.757 |
| R-HSA-9609690 | HCMV Early Events | 0.240998 | 0.618 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.130124 | 0.886 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.079444 | 1.100 |
| R-HSA-3229121 | Glycogen storage diseases | 0.225591 | 0.647 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.096918 | 1.014 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.053624 | 1.271 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.195702 | 0.708 |
| R-HSA-418597 | G alpha (z) signalling events | 0.166675 | 0.778 |
| R-HSA-69275 | G2/M Transition | 0.216403 | 0.665 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.221267 | 0.655 |
| R-HSA-75944 | Transcription from mitochondrial promoters | 0.045394 | 1.343 |
| R-HSA-205025 | NADE modulates death signalling | 0.067317 | 1.172 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.066279 | 1.179 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.198101 | 0.703 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.234544 | 0.630 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.115355 | 0.938 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.183175 | 0.737 |
| R-HSA-191859 | snRNP Assembly | 0.183175 | 0.737 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.191514 | 0.718 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.164392 | 0.784 |
| R-HSA-157118 | Signaling by NOTCH | 0.084228 | 1.075 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.053945 | 1.268 |
| R-HSA-9664873 | Pexophagy | 0.140175 | 0.853 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.138523 | 0.858 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.188723 | 0.724 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.082853 | 1.082 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.086307 | 1.064 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.216533 | 0.664 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.104187 | 0.982 |
| R-HSA-5260271 | Diseases of Immune System | 0.104187 | 0.982 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.052490 | 1.280 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.142468 | 0.846 |
| R-HSA-917937 | Iron uptake and transport | 0.073300 | 1.135 |
| R-HSA-114608 | Platelet degranulation | 0.084850 | 1.071 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.142468 | 0.846 |
| R-HSA-112040 | G-protein mediated events | 0.216798 | 0.664 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.078089 | 1.107 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.140175 | 0.853 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.169640 | 0.770 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.169640 | 0.770 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.169640 | 0.770 |
| R-HSA-69091 | Polymerase switching | 0.169640 | 0.770 |
| R-HSA-69109 | Leading Strand Synthesis | 0.169640 | 0.770 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.188723 | 0.724 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.207370 | 0.683 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.104187 | 0.982 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.104187 | 0.982 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.107875 | 0.967 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.046094 | 1.336 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.238086 | 0.623 |
| R-HSA-913531 | Interferon Signaling | 0.047570 | 1.323 |
| R-HSA-3371556 | Cellular response to heat stress | 0.073619 | 1.133 |
| R-HSA-68886 | M Phase | 0.046969 | 1.328 |
| R-HSA-422475 | Axon guidance | 0.125101 | 0.903 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.130124 | 0.886 |
| R-HSA-9663891 | Selective autophagy | 0.104420 | 0.981 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.096868 | 1.014 |
| R-HSA-165159 | MTOR signalling | 0.115355 | 0.938 |
| R-HSA-9675108 | Nervous system development | 0.165853 | 0.780 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.078089 | 1.107 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.088738 | 1.052 |
| R-HSA-164944 | Nef and signal transduction | 0.099265 | 1.003 |
| R-HSA-448706 | Interleukin-1 processing | 0.130124 | 0.886 |
| R-HSA-9613354 | Lipophagy | 0.130124 | 0.886 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.150111 | 0.824 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.096918 | 1.014 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.130689 | 0.884 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.187338 | 0.727 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.238086 | 0.623 |
| R-HSA-69242 | S Phase | 0.129105 | 0.889 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.221267 | 0.655 |
| R-HSA-9945266 | Differentiation of T cells | 0.207370 | 0.683 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.207370 | 0.683 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.073300 | 1.135 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.076080 | 1.119 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.225591 | 0.647 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.045304 | 1.344 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.063113 | 1.200 |
| R-HSA-69306 | DNA Replication | 0.139345 | 0.856 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.048123 | 1.318 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.223237 | 0.651 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.088738 | 1.052 |
| R-HSA-390666 | Serotonin receptors | 0.140175 | 0.853 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.086307 | 1.064 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.225591 | 0.647 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.100534 | 0.998 |
| R-HSA-446728 | Cell junction organization | 0.135346 | 0.869 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.107875 | 0.967 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.174894 | 0.757 |
| R-HSA-9675135 | Diseases of DNA repair | 0.130689 | 0.884 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.107035 | 0.970 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.188723 | 0.724 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.076746 | 1.115 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.195702 | 0.708 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.145152 | 0.838 |
| R-HSA-9711097 | Cellular response to starvation | 0.149900 | 0.824 |
| R-HSA-1500931 | Cell-Cell communication | 0.098507 | 1.007 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.107875 | 0.967 |
| R-HSA-418990 | Adherens junctions interactions | 0.145317 | 0.838 |
| R-HSA-2028269 | Signaling by Hippo | 0.225591 | 0.647 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.111599 | 0.952 |
| R-HSA-70171 | Glycolysis | 0.041425 | 1.383 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.185585 | 0.731 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.185585 | 0.731 |
| R-HSA-421270 | Cell-cell junction organization | 0.208740 | 0.680 |
| R-HSA-68882 | Mitotic Anaphase | 0.058665 | 1.232 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.059623 | 1.225 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.187338 | 0.727 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.207370 | 0.683 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.116611 | 0.933 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.169640 | 0.770 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.082853 | 1.082 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.067565 | 1.170 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.216858 | 0.664 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.134811 | 0.870 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.073293 | 1.135 |
| R-HSA-2262752 | Cellular responses to stress | 0.059117 | 1.228 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.089907 | 1.046 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.113295 | 0.946 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.121874 | 0.914 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.086062 | 1.065 |
| R-HSA-373760 | L1CAM interactions | 0.193078 | 0.714 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.107875 | 0.967 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.229554 | 0.639 |
| R-HSA-68875 | Mitotic Prophase | 0.204887 | 0.688 |
| R-HSA-111933 | Calmodulin induced events | 0.089803 | 1.047 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.043724 | 1.359 |
| R-HSA-111997 | CaM pathway | 0.089803 | 1.047 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.053945 | 1.268 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.099694 | 1.001 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.102046 | 0.991 |
| R-HSA-70326 | Glucose metabolism | 0.067565 | 1.170 |
| R-HSA-9733709 | Cardiogenesis | 0.076080 | 1.119 |
| R-HSA-111996 | Ca-dependent events | 0.115355 | 0.938 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.234544 | 0.630 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.174959 | 0.757 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.219064 | 0.659 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.052360 | 1.281 |
| R-HSA-112043 | PLC beta mediated events | 0.191514 | 0.718 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.154206 | 0.812 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.229554 | 0.639 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 0.078089 | 1.107 |
| R-HSA-4839726 | Chromatin organization | 0.204657 | 0.689 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.076172 | 1.118 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.040913 | 1.388 |
| R-HSA-168268 | Virus Assembly and Release | 0.207370 | 0.683 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.129384 | 0.888 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.140073 | 0.854 |
| R-HSA-1474165 | Reproduction | 0.241210 | 0.618 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.242358 | 0.616 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.242358 | 0.616 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.242358 | 0.616 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.243395 | 0.614 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.243395 | 0.614 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.243395 | 0.614 |
| R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids | 0.243395 | 0.614 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.243395 | 0.614 |
| R-HSA-449836 | Other interleukin signaling | 0.243395 | 0.614 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.243395 | 0.614 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.243395 | 0.614 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.246634 | 0.608 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.252144 | 0.598 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.252144 | 0.598 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.252144 | 0.598 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.252144 | 0.598 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.252144 | 0.598 |
| R-HSA-3322077 | Glycogen synthesis | 0.252144 | 0.598 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.252144 | 0.598 |
| R-HSA-373753 | Nephrin family interactions | 0.252144 | 0.598 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.258585 | 0.587 |
| R-HSA-210991 | Basigin interactions | 0.260792 | 0.584 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.260792 | 0.584 |
| R-HSA-72172 | mRNA Splicing | 0.263657 | 0.579 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.263759 | 0.579 |
| R-HSA-216083 | Integrin cell surface interactions | 0.263759 | 0.579 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.269340 | 0.570 |
| R-HSA-977347 | Serine metabolism | 0.269340 | 0.570 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.272235 | 0.565 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.272326 | 0.565 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.276609 | 0.558 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.277790 | 0.556 |
| R-HSA-1632852 | Macroautophagy | 0.278497 | 0.555 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.280890 | 0.551 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.285169 | 0.545 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.286143 | 0.543 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.286143 | 0.543 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.286143 | 0.543 |
| R-HSA-200425 | Carnitine shuttle | 0.286143 | 0.543 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.286143 | 0.543 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.286143 | 0.543 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.286143 | 0.543 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.289446 | 0.538 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.290561 | 0.537 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.294400 | 0.531 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.294400 | 0.531 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.300509 | 0.522 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.302562 | 0.519 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.302562 | 0.519 |
| R-HSA-3214842 | HDMs demethylate histones | 0.302562 | 0.519 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.306284 | 0.514 |
| R-HSA-70268 | Pyruvate metabolism | 0.306519 | 0.514 |
| R-HSA-3295583 | TRP channels | 0.310630 | 0.508 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.310630 | 0.508 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.315029 | 0.502 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.316292 | 0.500 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.316292 | 0.500 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.318605 | 0.497 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.318605 | 0.497 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.318605 | 0.497 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.318605 | 0.497 |
| R-HSA-73884 | Base Excision Repair | 0.319275 | 0.496 |
| R-HSA-9609507 | Protein localization | 0.319451 | 0.496 |
| R-HSA-73887 | Death Receptor Signaling | 0.322611 | 0.491 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.323515 | 0.490 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.325514 | 0.487 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.326489 | 0.486 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.326489 | 0.486 |
| R-HSA-622312 | Inflammasomes | 0.326489 | 0.486 |
| R-HSA-9612973 | Autophagy | 0.328932 | 0.483 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.334281 | 0.476 |
| R-HSA-5334118 | DNA methylation | 0.334281 | 0.476 |
| R-HSA-72312 | rRNA processing | 0.336151 | 0.473 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.340405 | 0.468 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.341984 | 0.466 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.341984 | 0.466 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.344608 | 0.463 |
| R-HSA-109581 | Apoptosis | 0.347882 | 0.459 |
| R-HSA-8939211 | ESR-mediated signaling | 0.349257 | 0.457 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.349599 | 0.456 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.349599 | 0.456 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.352988 | 0.452 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.352988 | 0.452 |
| R-HSA-9679506 | SARS-CoV Infections | 0.354183 | 0.451 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.354190 | 0.451 |
| R-HSA-9824446 | Viral Infection Pathways | 0.356411 | 0.448 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.357125 | 0.447 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.357165 | 0.447 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.360954 | 0.443 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.361331 | 0.442 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.361331 | 0.442 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.361331 | 0.442 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.361331 | 0.442 |
| R-HSA-5619102 | SLC transporter disorders | 0.363637 | 0.439 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.364566 | 0.438 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.364566 | 0.438 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.364566 | 0.438 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.364566 | 0.438 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.364566 | 0.438 |
| R-HSA-354192 | Integrin signaling | 0.364566 | 0.438 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.364566 | 0.438 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.365488 | 0.437 |
| R-HSA-3214847 | HATs acetylate histones | 0.365488 | 0.437 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.367832 | 0.434 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.367832 | 0.434 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.369634 | 0.432 |
| R-HSA-390522 | Striated Muscle Contraction | 0.371920 | 0.430 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.371920 | 0.430 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.371920 | 0.430 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.371920 | 0.430 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 0.371920 | 0.430 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.371920 | 0.430 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.373770 | 0.427 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.376200 | 0.425 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.377895 | 0.423 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.379190 | 0.421 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.379190 | 0.421 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.379190 | 0.421 |
| R-HSA-190861 | Gap junction assembly | 0.379190 | 0.421 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.379190 | 0.421 |
| R-HSA-5205647 | Mitophagy | 0.379190 | 0.421 |
| R-HSA-9609646 | HCMV Infection | 0.383334 | 0.416 |
| R-HSA-111885 | Opioid Signalling | 0.386111 | 0.413 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.391834 | 0.407 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.393479 | 0.405 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.393479 | 0.405 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.393479 | 0.405 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.394280 | 0.404 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.400500 | 0.397 |
| R-HSA-69239 | Synthesis of DNA | 0.402399 | 0.395 |
| R-HSA-211000 | Gene Silencing by RNA | 0.402399 | 0.395 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.406440 | 0.391 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.406440 | 0.391 |
| R-HSA-2559583 | Cellular Senescence | 0.407370 | 0.390 |
| R-HSA-1566948 | Elastic fibre formation | 0.407441 | 0.390 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.410467 | 0.387 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.410467 | 0.387 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.414302 | 0.383 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.414302 | 0.383 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.414482 | 0.382 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.414482 | 0.382 |
| R-HSA-8982491 | Glycogen metabolism | 0.421083 | 0.376 |
| R-HSA-9646399 | Aggrephagy | 0.421083 | 0.376 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.421083 | 0.376 |
| R-HSA-3371568 | Attenuation phase | 0.421083 | 0.376 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.421083 | 0.376 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.422469 | 0.374 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.422764 | 0.374 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.426442 | 0.370 |
| R-HSA-9607240 | FLT3 Signaling | 0.427787 | 0.369 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.427787 | 0.369 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.427787 | 0.369 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.427787 | 0.369 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.434345 | 0.362 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.434413 | 0.362 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.434413 | 0.362 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.434413 | 0.362 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.434413 | 0.362 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.438275 | 0.358 |
| R-HSA-991365 | Activation of GABAB receptors | 0.440963 | 0.356 |
| R-HSA-977444 | GABA B receptor activation | 0.440963 | 0.356 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.440963 | 0.356 |
| R-HSA-9710421 | Defective pyroptosis | 0.447438 | 0.349 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.447438 | 0.349 |
| R-HSA-73894 | DNA Repair | 0.452218 | 0.345 |
| R-HSA-190828 | Gap junction trafficking | 0.453838 | 0.343 |
| R-HSA-373752 | Netrin-1 signaling | 0.453838 | 0.343 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.453838 | 0.343 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.457699 | 0.339 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.457699 | 0.339 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.457699 | 0.339 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.458964 | 0.338 |
| R-HSA-109582 | Hemostasis | 0.459532 | 0.338 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.460164 | 0.337 |
| R-HSA-774815 | Nucleosome assembly | 0.460164 | 0.337 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.460164 | 0.337 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.460164 | 0.337 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.460164 | 0.337 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.460164 | 0.337 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.465360 | 0.332 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.466418 | 0.331 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.466418 | 0.331 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.466418 | 0.331 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.466418 | 0.331 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.466418 | 0.331 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.466418 | 0.331 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.466418 | 0.331 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.466418 | 0.331 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.466418 | 0.331 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.466418 | 0.331 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.466418 | 0.331 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.466418 | 0.331 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.469167 | 0.329 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.469167 | 0.329 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.472599 | 0.326 |
| R-HSA-437239 | Recycling pathway of L1 | 0.472599 | 0.326 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.474097 | 0.324 |
| R-HSA-5620924 | Intraflagellar transport | 0.478709 | 0.320 |
| R-HSA-9634597 | GPER1 signaling | 0.478709 | 0.320 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.478709 | 0.320 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.478709 | 0.320 |
| R-HSA-6798695 | Neutrophil degranulation | 0.481197 | 0.318 |
| R-HSA-69206 | G1/S Transition | 0.484232 | 0.315 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.484749 | 0.314 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.484749 | 0.314 |
| R-HSA-9766229 | Degradation of CDH1 | 0.484749 | 0.314 |
| R-HSA-5357801 | Programmed Cell Death | 0.485875 | 0.313 |
| R-HSA-109704 | PI3K Cascade | 0.490719 | 0.309 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.490719 | 0.309 |
| R-HSA-69481 | G2/M Checkpoints | 0.491665 | 0.308 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.496620 | 0.304 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.496620 | 0.304 |
| R-HSA-2514856 | The phototransduction cascade | 0.496620 | 0.304 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.502453 | 0.299 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.502453 | 0.299 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.502453 | 0.299 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.502453 | 0.299 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.502453 | 0.299 |
| R-HSA-1221632 | Meiotic synapsis | 0.508219 | 0.294 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.508219 | 0.294 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.508219 | 0.294 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.508219 | 0.294 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.508219 | 0.294 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.508219 | 0.294 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.513558 | 0.289 |
| R-HSA-72649 | Translation initiation complex formation | 0.513919 | 0.289 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.513919 | 0.289 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.519553 | 0.284 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.525122 | 0.280 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.525122 | 0.280 |
| R-HSA-75893 | TNF signaling | 0.525122 | 0.280 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.525122 | 0.280 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.525122 | 0.280 |
| R-HSA-112399 | IRS-mediated signalling | 0.530626 | 0.275 |
| R-HSA-163685 | Integration of energy metabolism | 0.531324 | 0.275 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.531324 | 0.275 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.536067 | 0.271 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.536067 | 0.271 |
| R-HSA-8953854 | Metabolism of RNA | 0.537849 | 0.269 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.538307 | 0.269 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.541446 | 0.266 |
| R-HSA-9033241 | Peroxisomal protein import | 0.541446 | 0.266 |
| R-HSA-186712 | Regulation of beta-cell development | 0.541446 | 0.266 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.541446 | 0.266 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.541446 | 0.266 |
| R-HSA-6807070 | PTEN Regulation | 0.541771 | 0.266 |
| R-HSA-977443 | GABA receptor activation | 0.546762 | 0.262 |
| R-HSA-983189 | Kinesins | 0.546762 | 0.262 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.546762 | 0.262 |
| R-HSA-162906 | HIV Infection | 0.548246 | 0.261 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.552017 | 0.258 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.552017 | 0.258 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.552017 | 0.258 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.552017 | 0.258 |
| R-HSA-450294 | MAP kinase activation | 0.552017 | 0.258 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.555450 | 0.255 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.557212 | 0.254 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.557212 | 0.254 |
| R-HSA-1268020 | Mitochondrial protein import | 0.557212 | 0.254 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.562347 | 0.250 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.562347 | 0.250 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.562347 | 0.250 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.562347 | 0.250 |
| R-HSA-8848021 | Signaling by PTK6 | 0.562347 | 0.250 |
| R-HSA-168256 | Immune System | 0.563512 | 0.249 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.567422 | 0.246 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.567422 | 0.246 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.568838 | 0.245 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.572439 | 0.242 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.572439 | 0.242 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.575423 | 0.240 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.577398 | 0.239 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.582299 | 0.235 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.582299 | 0.235 |
| R-HSA-1474244 | Extracellular matrix organization | 0.583523 | 0.234 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.585164 | 0.233 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.587145 | 0.231 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.587145 | 0.231 |
| R-HSA-2142753 | Arachidonate metabolism | 0.588374 | 0.230 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.594739 | 0.226 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.596668 | 0.224 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.596668 | 0.224 |
| R-HSA-448424 | Interleukin-17 signaling | 0.596668 | 0.224 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.600959 | 0.221 |
| R-HSA-72766 | Translation | 0.601091 | 0.221 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.601347 | 0.221 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.601347 | 0.221 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.601347 | 0.221 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.601347 | 0.221 |
| R-HSA-9610379 | HCMV Late Events | 0.604149 | 0.219 |
| R-HSA-162587 | HIV Life Cycle | 0.604149 | 0.219 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.605661 | 0.218 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.605973 | 0.218 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.605973 | 0.218 |
| R-HSA-1266738 | Developmental Biology | 0.608819 | 0.216 |
| R-HSA-877300 | Interferon gamma signaling | 0.610331 | 0.214 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.610545 | 0.214 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.610545 | 0.214 |
| R-HSA-9749641 | Aspirin ADME | 0.610545 | 0.214 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.613395 | 0.212 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.615064 | 0.211 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.615064 | 0.211 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.615064 | 0.211 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.615064 | 0.211 |
| R-HSA-1643685 | Disease | 0.616271 | 0.210 |
| R-HSA-380287 | Centrosome maturation | 0.619531 | 0.208 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.619531 | 0.208 |
| R-HSA-8852135 | Protein ubiquitination | 0.619531 | 0.208 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.619531 | 0.208 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.623946 | 0.205 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.628311 | 0.202 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.632625 | 0.199 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.632625 | 0.199 |
| R-HSA-4086400 | PCP/CE pathway | 0.632625 | 0.199 |
| R-HSA-9659379 | Sensory processing of sound | 0.636889 | 0.196 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.640139 | 0.194 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.641104 | 0.193 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.641104 | 0.193 |
| R-HSA-6806834 | Signaling by MET | 0.641104 | 0.193 |
| R-HSA-72306 | tRNA processing | 0.645886 | 0.190 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.648731 | 0.188 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.650325 | 0.187 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.651820 | 0.186 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.661461 | 0.179 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.665392 | 0.177 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.668217 | 0.175 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.669278 | 0.174 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.673119 | 0.172 |
| R-HSA-112316 | Neuronal System | 0.673467 | 0.172 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.676916 | 0.169 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.676916 | 0.169 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.684378 | 0.165 |
| R-HSA-202424 | Downstream TCR signaling | 0.684378 | 0.165 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.688045 | 0.162 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.691669 | 0.160 |
| R-HSA-391251 | Protein folding | 0.695251 | 0.158 |
| R-HSA-983712 | Ion channel transport | 0.696892 | 0.157 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.701893 | 0.154 |
| R-HSA-1474290 | Collagen formation | 0.702292 | 0.153 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.704368 | 0.152 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.712551 | 0.147 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.712551 | 0.147 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.719194 | 0.143 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.725685 | 0.139 |
| R-HSA-1483255 | PI Metabolism | 0.732026 | 0.135 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.735142 | 0.134 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.738222 | 0.132 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.741266 | 0.130 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.741266 | 0.130 |
| R-HSA-9833110 | RSV-host interactions | 0.741266 | 0.130 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.747249 | 0.127 |
| R-HSA-397014 | Muscle contraction | 0.752513 | 0.123 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.753094 | 0.123 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.755966 | 0.121 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.758620 | 0.120 |
| R-HSA-202403 | TCR signaling | 0.758805 | 0.120 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.767126 | 0.115 |
| R-HSA-8951664 | Neddylation | 0.771002 | 0.113 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.775161 | 0.111 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.777778 | 0.109 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.777778 | 0.109 |
| R-HSA-5663205 | Infectious disease | 0.785577 | 0.105 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.797649 | 0.098 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.797649 | 0.098 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.800005 | 0.097 |
| R-HSA-194138 | Signaling by VEGF | 0.804636 | 0.094 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.806912 | 0.093 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.811384 | 0.091 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.822118 | 0.085 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.832244 | 0.080 |
| R-HSA-5173105 | O-linked glycosylation | 0.834199 | 0.079 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.834199 | 0.079 |
| R-HSA-5368287 | Mitochondrial translation | 0.836132 | 0.078 |
| R-HSA-416476 | G alpha (q) signalling events | 0.843643 | 0.074 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.847267 | 0.072 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.849048 | 0.071 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.850282 | 0.070 |
| R-HSA-2187338 | Visual phototransduction | 0.854268 | 0.068 |
| R-HSA-166520 | Signaling by NTRKs | 0.855968 | 0.068 |
| R-HSA-9758941 | Gastrulation | 0.857648 | 0.067 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.859309 | 0.066 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.859309 | 0.066 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.862374 | 0.064 |
| R-HSA-9658195 | Leishmania infection | 0.866112 | 0.062 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.866112 | 0.062 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.871919 | 0.060 |
| R-HSA-8978868 | Fatty acid metabolism | 0.876226 | 0.057 |
| R-HSA-1280218 | Adaptive Immune System | 0.877453 | 0.057 |
| R-HSA-597592 | Post-translational protein modification | 0.887967 | 0.052 |
| R-HSA-418555 | G alpha (s) signalling events | 0.891341 | 0.050 |
| R-HSA-199991 | Membrane Trafficking | 0.891422 | 0.050 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.893865 | 0.049 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.893865 | 0.049 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.895105 | 0.048 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.896331 | 0.048 |
| R-HSA-611105 | Respiratory electron transport | 0.899923 | 0.046 |
| R-HSA-382551 | Transport of small molecules | 0.900758 | 0.045 |
| R-HSA-5617833 | Cilium Assembly | 0.913096 | 0.039 |
| R-HSA-392499 | Metabolism of proteins | 0.918867 | 0.037 |
| R-HSA-168249 | Innate Immune System | 0.920191 | 0.036 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.922745 | 0.035 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.922865 | 0.035 |
| R-HSA-428157 | Sphingolipid metabolism | 0.923649 | 0.034 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.925426 | 0.034 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.925426 | 0.034 |
| R-HSA-6805567 | Keratinization | 0.928858 | 0.032 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.934489 | 0.029 |
| R-HSA-9748784 | Drug ADME | 0.938238 | 0.028 |
| R-HSA-15869 | Metabolism of nucleotides | 0.950051 | 0.022 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.950637 | 0.022 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.956249 | 0.019 |
| R-HSA-418594 | G alpha (i) signalling events | 0.960373 | 0.018 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.970997 | 0.013 |
| R-HSA-1483257 | Phospholipid metabolism | 0.975134 | 0.011 |
| R-HSA-195721 | Signaling by WNT | 0.976002 | 0.011 |
| R-HSA-388396 | GPCR downstream signalling | 0.983934 | 0.007 |
| R-HSA-211859 | Biological oxidations | 0.987802 | 0.005 |
| R-HSA-372790 | Signaling by GPCR | 0.992301 | 0.003 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.992422 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 0.994888 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 0.999269 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999901 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999928 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999996 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.904 | 0.279 | 2 | 0.920 |
MOS |
0.886 | 0.176 | 1 | 0.871 |
DSTYK |
0.882 | 0.092 | 2 | 0.910 |
GCN2 |
0.882 | -0.070 | 2 | 0.845 |
NEK6 |
0.882 | 0.134 | -2 | 0.933 |
ULK2 |
0.881 | -0.013 | 2 | 0.862 |
PRPK |
0.881 | -0.079 | -1 | 0.885 |
CDC7 |
0.881 | 0.010 | 1 | 0.851 |
BMPR2 |
0.877 | 0.014 | -2 | 0.944 |
NUAK2 |
0.877 | 0.131 | -3 | 0.858 |
NEK7 |
0.877 | 0.017 | -3 | 0.833 |
RAF1 |
0.877 | -0.062 | 1 | 0.835 |
PIM3 |
0.876 | 0.034 | -3 | 0.846 |
MLK1 |
0.876 | 0.072 | 2 | 0.875 |
MARK4 |
0.876 | 0.147 | 4 | 0.900 |
IKKB |
0.876 | -0.098 | -2 | 0.819 |
TBK1 |
0.875 | -0.086 | 1 | 0.725 |
TGFBR2 |
0.875 | 0.060 | -2 | 0.870 |
AMPKA1 |
0.874 | 0.137 | -3 | 0.878 |
CAMK1B |
0.873 | -0.001 | -3 | 0.870 |
PKN3 |
0.873 | 0.038 | -3 | 0.850 |
MST4 |
0.873 | 0.098 | 2 | 0.887 |
CAMK2G |
0.872 | -0.063 | 2 | 0.848 |
RIPK3 |
0.872 | -0.015 | 3 | 0.787 |
TSSK2 |
0.871 | 0.150 | -5 | 0.837 |
MTOR |
0.871 | -0.141 | 1 | 0.739 |
CLK3 |
0.871 | 0.107 | 1 | 0.770 |
ATR |
0.871 | -0.017 | 1 | 0.829 |
IKKE |
0.870 | -0.122 | 1 | 0.715 |
MLK3 |
0.870 | 0.143 | 2 | 0.831 |
PKN2 |
0.870 | 0.064 | -3 | 0.867 |
NIK |
0.870 | 0.034 | -3 | 0.905 |
WNK1 |
0.870 | 0.023 | -2 | 0.884 |
PDHK4 |
0.870 | -0.328 | 1 | 0.835 |
NLK |
0.870 | -0.043 | 1 | 0.751 |
SKMLCK |
0.869 | 0.039 | -2 | 0.851 |
ULK1 |
0.869 | -0.094 | -3 | 0.840 |
IKKA |
0.869 | 0.017 | -2 | 0.820 |
GRK5 |
0.869 | -0.093 | -3 | 0.894 |
PRKD1 |
0.869 | 0.062 | -3 | 0.818 |
NUAK1 |
0.869 | 0.125 | -3 | 0.812 |
PKCD |
0.868 | 0.108 | 2 | 0.882 |
TSSK1 |
0.868 | 0.151 | -3 | 0.892 |
IRE1 |
0.868 | 0.044 | 1 | 0.828 |
ANKRD3 |
0.868 | 0.073 | 1 | 0.853 |
NEK9 |
0.868 | -0.018 | 2 | 0.896 |
CHAK2 |
0.867 | -0.016 | -1 | 0.847 |
FAM20C |
0.867 | 0.095 | 2 | 0.595 |
AMPKA2 |
0.867 | 0.108 | -3 | 0.844 |
ERK5 |
0.867 | 0.021 | 1 | 0.760 |
CDKL1 |
0.867 | -0.023 | -3 | 0.787 |
HUNK |
0.867 | -0.068 | 2 | 0.843 |
NDR2 |
0.867 | -0.060 | -3 | 0.861 |
PDHK1 |
0.867 | -0.237 | 1 | 0.819 |
GRK1 |
0.867 | 0.078 | -2 | 0.852 |
IRE2 |
0.866 | 0.091 | 2 | 0.859 |
BMPR1B |
0.865 | 0.186 | 1 | 0.806 |
WNK3 |
0.864 | -0.152 | 1 | 0.827 |
MLK2 |
0.864 | -0.009 | 2 | 0.871 |
PLK1 |
0.864 | 0.068 | -2 | 0.902 |
PRKD2 |
0.864 | 0.057 | -3 | 0.779 |
ATM |
0.863 | 0.034 | 1 | 0.772 |
BCKDK |
0.863 | -0.151 | -1 | 0.860 |
KIS |
0.863 | -0.015 | 1 | 0.580 |
GRK4 |
0.862 | -0.063 | -2 | 0.900 |
NDR1 |
0.862 | -0.074 | -3 | 0.852 |
QSK |
0.862 | 0.129 | 4 | 0.885 |
MLK4 |
0.862 | 0.079 | 2 | 0.797 |
DAPK2 |
0.862 | -0.047 | -3 | 0.870 |
PIM1 |
0.862 | 0.036 | -3 | 0.794 |
GRK6 |
0.862 | -0.048 | 1 | 0.833 |
CDKL5 |
0.861 | 0.012 | -3 | 0.772 |
CAMLCK |
0.861 | -0.079 | -2 | 0.847 |
MELK |
0.861 | 0.055 | -3 | 0.824 |
QIK |
0.861 | 0.040 | -3 | 0.847 |
NIM1 |
0.861 | -0.047 | 3 | 0.810 |
PKR |
0.860 | 0.088 | 1 | 0.856 |
MASTL |
0.859 | -0.256 | -2 | 0.878 |
CAMK2D |
0.859 | -0.063 | -3 | 0.846 |
TGFBR1 |
0.859 | 0.092 | -2 | 0.878 |
SIK |
0.859 | 0.086 | -3 | 0.783 |
TTBK2 |
0.859 | -0.146 | 2 | 0.791 |
RIPK1 |
0.859 | -0.159 | 1 | 0.839 |
ALK4 |
0.858 | 0.049 | -2 | 0.899 |
MARK2 |
0.858 | 0.143 | 4 | 0.834 |
MAPKAPK3 |
0.858 | -0.053 | -3 | 0.783 |
ACVR2B |
0.858 | 0.115 | -2 | 0.884 |
PKCB |
0.857 | 0.083 | 2 | 0.833 |
MARK3 |
0.857 | 0.139 | 4 | 0.867 |
DLK |
0.857 | -0.157 | 1 | 0.827 |
YSK4 |
0.857 | -0.006 | 1 | 0.767 |
RSK2 |
0.857 | -0.041 | -3 | 0.758 |
ACVR2A |
0.856 | 0.094 | -2 | 0.871 |
CAMK4 |
0.856 | -0.068 | -3 | 0.851 |
LATS2 |
0.856 | -0.070 | -5 | 0.686 |
P90RSK |
0.855 | -0.073 | -3 | 0.761 |
PKCG |
0.855 | 0.038 | 2 | 0.840 |
GRK7 |
0.854 | 0.080 | 1 | 0.744 |
PHKG1 |
0.854 | -0.005 | -3 | 0.848 |
RSK3 |
0.854 | -0.082 | -3 | 0.763 |
P70S6KB |
0.854 | -0.064 | -3 | 0.804 |
PKCA |
0.854 | 0.058 | 2 | 0.830 |
CAMK2B |
0.854 | 0.011 | 2 | 0.790 |
SRPK1 |
0.854 | -0.017 | -3 | 0.734 |
CHK1 |
0.853 | 0.079 | -3 | 0.853 |
MNK2 |
0.853 | -0.010 | -2 | 0.775 |
PRKD3 |
0.853 | 0.013 | -3 | 0.745 |
HRI |
0.853 | -0.014 | -2 | 0.914 |
HIPK4 |
0.852 | -0.064 | 1 | 0.737 |
NEK2 |
0.852 | -0.063 | 2 | 0.877 |
LATS1 |
0.852 | 0.020 | -3 | 0.854 |
PKCZ |
0.852 | 0.009 | 2 | 0.864 |
CHAK1 |
0.852 | -0.080 | 2 | 0.837 |
PKACG |
0.852 | -0.083 | -2 | 0.724 |
BRSK2 |
0.851 | -0.001 | -3 | 0.839 |
PLK3 |
0.851 | -0.020 | 2 | 0.809 |
BRSK1 |
0.851 | 0.001 | -3 | 0.814 |
ALK2 |
0.851 | 0.067 | -2 | 0.884 |
TLK2 |
0.851 | -0.017 | 1 | 0.819 |
PKCH |
0.851 | 0.012 | 2 | 0.827 |
MAPKAPK2 |
0.850 | -0.038 | -3 | 0.734 |
ICK |
0.850 | -0.085 | -3 | 0.823 |
VRK2 |
0.850 | -0.149 | 1 | 0.855 |
PERK |
0.850 | -0.035 | -2 | 0.906 |
MARK1 |
0.849 | 0.073 | 4 | 0.872 |
MEKK2 |
0.849 | 0.047 | 2 | 0.861 |
PAK3 |
0.849 | -0.120 | -2 | 0.756 |
PAK1 |
0.849 | -0.084 | -2 | 0.752 |
MEKK1 |
0.848 | -0.020 | 1 | 0.809 |
PLK4 |
0.848 | -0.058 | 2 | 0.720 |
IRAK4 |
0.848 | 0.008 | 1 | 0.841 |
BRAF |
0.848 | 0.016 | -4 | 0.861 |
MEK1 |
0.848 | -0.183 | 2 | 0.855 |
NEK5 |
0.848 | 0.050 | 1 | 0.854 |
SMG1 |
0.848 | -0.063 | 1 | 0.785 |
CDK8 |
0.848 | -0.102 | 1 | 0.550 |
AURC |
0.848 | -0.030 | -2 | 0.608 |
CDK5 |
0.848 | 0.005 | 1 | 0.580 |
SRPK2 |
0.848 | -0.014 | -3 | 0.657 |
BMPR1A |
0.847 | 0.137 | 1 | 0.783 |
ZAK |
0.847 | -0.036 | 1 | 0.776 |
MEKK3 |
0.846 | -0.072 | 1 | 0.794 |
SSTK |
0.846 | 0.085 | 4 | 0.864 |
CAMK2A |
0.846 | -0.024 | 2 | 0.803 |
MNK1 |
0.846 | -0.017 | -2 | 0.790 |
CAMK1G |
0.846 | -0.020 | -3 | 0.767 |
SNRK |
0.845 | -0.153 | 2 | 0.770 |
TLK1 |
0.845 | -0.023 | -2 | 0.906 |
GRK2 |
0.845 | -0.026 | -2 | 0.780 |
SRPK3 |
0.844 | -0.034 | -3 | 0.713 |
TAO3 |
0.844 | 0.091 | 1 | 0.776 |
MYLK4 |
0.844 | -0.069 | -2 | 0.744 |
MST3 |
0.843 | 0.072 | 2 | 0.878 |
MSK2 |
0.842 | -0.135 | -3 | 0.726 |
CK1E |
0.842 | 0.008 | -3 | 0.579 |
PRP4 |
0.842 | 0.052 | -3 | 0.826 |
DCAMKL1 |
0.842 | -0.011 | -3 | 0.815 |
AURB |
0.841 | -0.057 | -2 | 0.610 |
PHKG2 |
0.841 | 0.004 | -3 | 0.833 |
PINK1 |
0.841 | -0.119 | 1 | 0.803 |
PAK6 |
0.841 | -0.025 | -2 | 0.665 |
MEK5 |
0.841 | -0.202 | 2 | 0.867 |
WNK4 |
0.841 | -0.095 | -2 | 0.883 |
DNAPK |
0.841 | -0.039 | 1 | 0.681 |
CDK1 |
0.841 | -0.032 | 1 | 0.504 |
PKCT |
0.841 | 0.000 | 2 | 0.837 |
PAK2 |
0.841 | -0.146 | -2 | 0.742 |
SGK3 |
0.841 | -0.038 | -3 | 0.776 |
PKG2 |
0.840 | -0.043 | -2 | 0.635 |
CDK19 |
0.840 | -0.108 | 1 | 0.504 |
DRAK1 |
0.840 | -0.101 | 1 | 0.766 |
CDK2 |
0.839 | -0.025 | 1 | 0.595 |
PIM2 |
0.839 | -0.023 | -3 | 0.746 |
NEK8 |
0.839 | -0.021 | 2 | 0.894 |
TAO2 |
0.837 | 0.043 | 2 | 0.925 |
MST2 |
0.837 | 0.083 | 1 | 0.796 |
CDK18 |
0.837 | -0.052 | 1 | 0.476 |
RSK4 |
0.836 | -0.071 | -3 | 0.736 |
DCAMKL2 |
0.836 | -0.020 | -3 | 0.830 |
EEF2K |
0.836 | 0.099 | 3 | 0.864 |
PKACB |
0.836 | -0.041 | -2 | 0.635 |
AKT2 |
0.836 | -0.041 | -3 | 0.684 |
IRAK1 |
0.835 | -0.192 | -1 | 0.770 |
CDK7 |
0.835 | -0.139 | 1 | 0.557 |
CDK13 |
0.835 | -0.119 | 1 | 0.526 |
P38A |
0.835 | -0.078 | 1 | 0.602 |
GAK |
0.835 | 0.058 | 1 | 0.837 |
MSK1 |
0.835 | -0.105 | -3 | 0.743 |
SMMLCK |
0.834 | -0.078 | -3 | 0.821 |
DYRK2 |
0.834 | -0.113 | 1 | 0.598 |
MAPKAPK5 |
0.833 | -0.196 | -3 | 0.704 |
MPSK1 |
0.833 | 0.003 | 1 | 0.798 |
CLK4 |
0.833 | -0.080 | -3 | 0.773 |
CAMKK1 |
0.833 | -0.142 | -2 | 0.807 |
CLK1 |
0.833 | -0.043 | -3 | 0.753 |
MINK |
0.833 | 0.045 | 1 | 0.793 |
AURA |
0.832 | -0.089 | -2 | 0.581 |
CK1D |
0.832 | 0.005 | -3 | 0.531 |
TNIK |
0.832 | 0.094 | 3 | 0.883 |
PKCI |
0.832 | -0.021 | 2 | 0.833 |
TTBK1 |
0.832 | -0.173 | 2 | 0.724 |
CK2A2 |
0.832 | 0.080 | 1 | 0.719 |
HGK |
0.832 | 0.041 | 3 | 0.886 |
CAMK1D |
0.831 | -0.016 | -3 | 0.699 |
CDK17 |
0.831 | -0.075 | 1 | 0.410 |
JNK3 |
0.831 | -0.100 | 1 | 0.531 |
GRK3 |
0.831 | -0.026 | -2 | 0.737 |
PRKX |
0.830 | -0.007 | -3 | 0.702 |
CK1G1 |
0.830 | -0.056 | -3 | 0.580 |
ERK2 |
0.830 | -0.116 | 1 | 0.563 |
GCK |
0.830 | 0.034 | 1 | 0.784 |
TAK1 |
0.830 | 0.020 | 1 | 0.841 |
ERK1 |
0.830 | -0.089 | 1 | 0.503 |
GSK3B |
0.829 | -0.026 | 4 | 0.457 |
AKT1 |
0.829 | -0.031 | -3 | 0.710 |
P38B |
0.829 | -0.074 | 1 | 0.514 |
NEK11 |
0.829 | -0.168 | 1 | 0.774 |
NEK4 |
0.829 | -0.089 | 1 | 0.804 |
JNK2 |
0.828 | -0.090 | 1 | 0.486 |
PKCE |
0.828 | 0.028 | 2 | 0.825 |
P38G |
0.828 | -0.080 | 1 | 0.403 |
GSK3A |
0.828 | 0.010 | 4 | 0.464 |
LKB1 |
0.828 | -0.088 | -3 | 0.862 |
DAPK3 |
0.827 | -0.023 | -3 | 0.816 |
TTK |
0.827 | 0.178 | -2 | 0.901 |
MST1 |
0.827 | 0.038 | 1 | 0.782 |
CDK3 |
0.827 | -0.001 | 1 | 0.432 |
PASK |
0.827 | -0.099 | -3 | 0.853 |
VRK1 |
0.827 | -0.021 | 2 | 0.905 |
HIPK1 |
0.827 | -0.081 | 1 | 0.618 |
CK1A2 |
0.826 | -0.018 | -3 | 0.528 |
CDK12 |
0.826 | -0.123 | 1 | 0.493 |
PLK2 |
0.826 | 0.017 | -3 | 0.829 |
PKN1 |
0.826 | -0.022 | -3 | 0.720 |
NEK1 |
0.826 | -0.022 | 1 | 0.827 |
PDK1 |
0.826 | -0.123 | 1 | 0.786 |
CDK16 |
0.825 | -0.031 | 1 | 0.434 |
MAP3K15 |
0.825 | -0.086 | 1 | 0.755 |
P70S6K |
0.824 | -0.126 | -3 | 0.700 |
CAMKK2 |
0.824 | -0.167 | -2 | 0.792 |
MEKK6 |
0.824 | -0.090 | 1 | 0.805 |
LRRK2 |
0.824 | -0.100 | 2 | 0.910 |
ERK7 |
0.824 | 0.021 | 2 | 0.604 |
CAMK1A |
0.823 | 0.004 | -3 | 0.665 |
CDK14 |
0.823 | -0.084 | 1 | 0.523 |
CDK9 |
0.823 | -0.161 | 1 | 0.532 |
LOK |
0.822 | -0.027 | -2 | 0.810 |
HIPK2 |
0.822 | -0.087 | 1 | 0.497 |
HPK1 |
0.822 | -0.024 | 1 | 0.760 |
YSK1 |
0.821 | -0.007 | 2 | 0.872 |
PKACA |
0.821 | -0.065 | -2 | 0.572 |
DYRK1A |
0.821 | -0.127 | 1 | 0.638 |
HIPK3 |
0.821 | -0.126 | 1 | 0.618 |
KHS1 |
0.820 | 0.034 | 1 | 0.764 |
CHK2 |
0.820 | -0.033 | -3 | 0.635 |
CK2A1 |
0.820 | 0.050 | 1 | 0.696 |
KHS2 |
0.820 | 0.071 | 1 | 0.770 |
CLK2 |
0.820 | -0.035 | -3 | 0.760 |
PAK5 |
0.819 | -0.108 | -2 | 0.605 |
SLK |
0.819 | -0.043 | -2 | 0.771 |
BUB1 |
0.818 | 0.092 | -5 | 0.807 |
P38D |
0.817 | -0.078 | 1 | 0.434 |
DAPK1 |
0.817 | -0.073 | -3 | 0.792 |
OSR1 |
0.817 | 0.039 | 2 | 0.834 |
STK33 |
0.816 | -0.162 | 2 | 0.702 |
ROCK2 |
0.816 | -0.016 | -3 | 0.808 |
RIPK2 |
0.816 | -0.256 | 1 | 0.731 |
PAK4 |
0.816 | -0.104 | -2 | 0.606 |
MRCKB |
0.814 | -0.048 | -3 | 0.757 |
CDK10 |
0.814 | -0.076 | 1 | 0.508 |
PDHK3_TYR |
0.813 | 0.095 | 4 | 0.882 |
PBK |
0.813 | -0.011 | 1 | 0.764 |
DYRK1B |
0.813 | -0.136 | 1 | 0.536 |
DYRK3 |
0.812 | -0.124 | 1 | 0.627 |
MRCKA |
0.812 | -0.059 | -3 | 0.771 |
AKT3 |
0.812 | -0.055 | -3 | 0.611 |
MYO3B |
0.812 | 0.052 | 2 | 0.889 |
CDK6 |
0.811 | -0.073 | 1 | 0.502 |
MEK2 |
0.811 | -0.278 | 2 | 0.845 |
NEK3 |
0.811 | -0.133 | 1 | 0.766 |
MYO3A |
0.810 | 0.049 | 1 | 0.784 |
SGK1 |
0.808 | -0.070 | -3 | 0.597 |
DMPK1 |
0.808 | 0.004 | -3 | 0.780 |
DYRK4 |
0.808 | -0.144 | 1 | 0.502 |
TAO1 |
0.807 | -0.005 | 1 | 0.713 |
TESK1_TYR |
0.807 | -0.046 | 3 | 0.891 |
EPHA6 |
0.806 | 0.127 | -1 | 0.905 |
HASPIN |
0.806 | -0.025 | -1 | 0.670 |
CDK4 |
0.806 | -0.102 | 1 | 0.478 |
BMPR2_TYR |
0.806 | 0.039 | -1 | 0.911 |
PDHK4_TYR |
0.804 | -0.001 | 2 | 0.891 |
MAP2K4_TYR |
0.804 | -0.112 | -1 | 0.910 |
MAP2K6_TYR |
0.804 | -0.042 | -1 | 0.921 |
JNK1 |
0.803 | -0.136 | 1 | 0.469 |
MAP2K7_TYR |
0.803 | -0.201 | 2 | 0.899 |
ROS1 |
0.803 | 0.062 | 3 | 0.821 |
PINK1_TYR |
0.803 | -0.110 | 1 | 0.834 |
BIKE |
0.803 | 0.032 | 1 | 0.710 |
PKMYT1_TYR |
0.803 | -0.112 | 3 | 0.865 |
ROCK1 |
0.803 | -0.039 | -3 | 0.776 |
ALPHAK3 |
0.803 | -0.040 | -1 | 0.831 |
TYK2 |
0.802 | -0.014 | 1 | 0.798 |
TYRO3 |
0.802 | 0.020 | 3 | 0.839 |
EPHB4 |
0.802 | 0.087 | -1 | 0.890 |
PDHK1_TYR |
0.801 | -0.070 | -1 | 0.918 |
MAK |
0.801 | -0.043 | -2 | 0.696 |
ABL2 |
0.800 | 0.070 | -1 | 0.845 |
SBK |
0.800 | -0.071 | -3 | 0.555 |
ASK1 |
0.800 | -0.164 | 1 | 0.740 |
LIMK2_TYR |
0.800 | -0.027 | -3 | 0.907 |
RET |
0.799 | -0.070 | 1 | 0.796 |
PKG1 |
0.799 | -0.103 | -2 | 0.547 |
MOK |
0.799 | -0.063 | 1 | 0.665 |
CSF1R |
0.798 | 0.001 | 3 | 0.834 |
FGR |
0.798 | 0.027 | 1 | 0.870 |
MST1R |
0.798 | -0.045 | 3 | 0.844 |
ABL1 |
0.798 | 0.055 | -1 | 0.831 |
LIMK1_TYR |
0.797 | -0.128 | 2 | 0.917 |
FER |
0.797 | -0.004 | 1 | 0.875 |
JAK2 |
0.797 | -0.056 | 1 | 0.786 |
TXK |
0.797 | 0.115 | 1 | 0.845 |
INSRR |
0.797 | 0.032 | 3 | 0.795 |
JAK3 |
0.796 | 0.008 | 1 | 0.783 |
CK1A |
0.796 | -0.028 | -3 | 0.443 |
LCK |
0.796 | 0.100 | -1 | 0.834 |
HCK |
0.796 | 0.037 | -1 | 0.835 |
PDGFRB |
0.795 | -0.010 | 3 | 0.850 |
TNNI3K_TYR |
0.795 | 0.102 | 1 | 0.822 |
BLK |
0.794 | 0.136 | -1 | 0.834 |
TNK2 |
0.793 | 0.020 | 3 | 0.803 |
FLT3 |
0.793 | -0.023 | 3 | 0.831 |
DDR1 |
0.792 | -0.120 | 4 | 0.816 |
KDR |
0.792 | 0.019 | 3 | 0.797 |
EPHB1 |
0.792 | 0.022 | 1 | 0.846 |
EPHB3 |
0.792 | 0.026 | -1 | 0.874 |
STLK3 |
0.792 | -0.178 | 1 | 0.742 |
EPHB2 |
0.791 | 0.058 | -1 | 0.870 |
ITK |
0.791 | 0.008 | -1 | 0.826 |
YES1 |
0.791 | -0.029 | -1 | 0.830 |
YANK3 |
0.791 | -0.089 | 2 | 0.470 |
CRIK |
0.790 | -0.092 | -3 | 0.694 |
SRMS |
0.790 | -0.032 | 1 | 0.858 |
KIT |
0.790 | -0.055 | 3 | 0.834 |
JAK1 |
0.789 | 0.006 | 1 | 0.729 |
EPHA4 |
0.788 | -0.012 | 2 | 0.796 |
MERTK |
0.788 | -0.011 | 3 | 0.800 |
ALK |
0.787 | -0.024 | 3 | 0.776 |
MET |
0.787 | -0.015 | 3 | 0.820 |
FGFR2 |
0.787 | -0.082 | 3 | 0.822 |
WEE1_TYR |
0.787 | -0.008 | -1 | 0.785 |
PDGFRA |
0.786 | -0.104 | 3 | 0.850 |
AXL |
0.786 | -0.062 | 3 | 0.813 |
FGFR1 |
0.786 | -0.064 | 3 | 0.805 |
TEC |
0.786 | -0.012 | -1 | 0.755 |
BMX |
0.785 | -0.002 | -1 | 0.755 |
LTK |
0.785 | -0.038 | 3 | 0.784 |
BTK |
0.785 | -0.108 | -1 | 0.783 |
TNK1 |
0.785 | -0.070 | 3 | 0.810 |
INSR |
0.783 | -0.042 | 3 | 0.768 |
NTRK2 |
0.783 | -0.067 | 3 | 0.796 |
FRK |
0.783 | -0.024 | -1 | 0.848 |
FLT1 |
0.783 | -0.028 | -1 | 0.903 |
AAK1 |
0.782 | 0.059 | 1 | 0.598 |
TEK |
0.782 | -0.137 | 3 | 0.782 |
NTRK1 |
0.782 | -0.109 | -1 | 0.884 |
PTK6 |
0.781 | -0.141 | -1 | 0.765 |
EPHA7 |
0.781 | -0.010 | 2 | 0.821 |
FYN |
0.781 | 0.027 | -1 | 0.806 |
LYN |
0.780 | -0.029 | 3 | 0.749 |
NTRK3 |
0.779 | -0.056 | -1 | 0.841 |
NEK10_TYR |
0.779 | -0.155 | 1 | 0.681 |
EPHA3 |
0.778 | -0.069 | 2 | 0.791 |
EPHA1 |
0.778 | -0.064 | 3 | 0.802 |
ERBB2 |
0.778 | -0.131 | 1 | 0.743 |
FGFR3 |
0.777 | -0.092 | 3 | 0.799 |
FLT4 |
0.777 | -0.106 | 3 | 0.781 |
EPHA5 |
0.776 | -0.005 | 2 | 0.789 |
PTK2B |
0.776 | -0.019 | -1 | 0.781 |
PTK2 |
0.775 | 0.094 | -1 | 0.847 |
MATK |
0.774 | -0.072 | -1 | 0.774 |
DDR2 |
0.774 | -0.003 | 3 | 0.788 |
EPHA8 |
0.773 | -0.031 | -1 | 0.851 |
CK1G3 |
0.773 | -0.050 | -3 | 0.400 |
EGFR |
0.772 | -0.057 | 1 | 0.654 |
SRC |
0.771 | -0.063 | -1 | 0.795 |
SYK |
0.769 | 0.042 | -1 | 0.840 |
MUSK |
0.769 | -0.088 | 1 | 0.652 |
FGFR4 |
0.767 | -0.072 | -1 | 0.826 |
IGF1R |
0.766 | -0.081 | 3 | 0.704 |
CSK |
0.765 | -0.151 | 2 | 0.823 |
EPHA2 |
0.764 | -0.030 | -1 | 0.841 |
YANK2 |
0.761 | -0.107 | 2 | 0.483 |
ERBB4 |
0.758 | -0.058 | 1 | 0.673 |
CK1G2 |
0.757 | -0.051 | -3 | 0.501 |
FES |
0.750 | -0.112 | -1 | 0.730 |
ZAP70 |
0.747 | -0.038 | -1 | 0.767 |