Motif 705 (n=119)

Position-wise Probabilities
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uniprot genes site source protein function
A0A0B4J1V8 PPAN-P2RY11 S228 ochoa HCG2039996 (PPAN-P2RY11 readthrough) None
O14920 IKBKB S733 psp Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}.
O15357 INPPL1 S300 ochoa Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}.
O43166 SIPA1L1 S1391 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43379 WDR62 S614 ochoa WD repeat-containing protein 62 Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.
O43379 WDR62 S1436 ochoa WD repeat-containing protein 62 Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.
O60292 SIPA1L3 S451 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O75475 PSIP1 S482 ochoa PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}.
O94876 TMCC1 S382 ochoa Transmembrane and coiled-coil domains protein 1 Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). {ECO:0000269|PubMed:30220460}.
O95163 ELP1 S173 ochoa Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150) Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059). {ECO:0000250|UniProtKB:Q06706, ECO:0000250|UniProtKB:Q7TT37, ECO:0000269|PubMed:9751059, ECO:0000303|PubMed:29332244}.
O95427 PIGN S94 ochoa GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (GPI-ethanolamine transferase I) (GPI-ETI) (MCD4 homolog) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) Ethanolamine phosphate transferase that catalyzes an ethanolamine phosphate (EtNP) transfer from phosphatidylethanolamine (PE) to the 2-OH position of the first alpha-1,4-linked mannose of the alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol (also termed H3) intermediate to generate an alpha-D-Man-(1->6)-2-PEtn-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the eighth step of the glycosylphosphatidylinositol-anchor biosynthesis (By similarity). May act as suppressor of replication stress and chromosome missegregation (PubMed:23446422). {ECO:0000250|UniProtKB:Q9R1S3, ECO:0000269|PubMed:23446422}.
P00505 GOT2 S360 ochoa Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}.
P01100 FOS S308 psp Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos) Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}.
P07355 ANXA2 S184 ochoa Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}.
P12882 MYH1 S668 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 S664 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13535 MYH8 S667 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P19634 SLC9A1 S648 ochoa|psp Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}.
P23497 SP100 S223 ochoa Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}.
P29350 PTPN6 S26 ochoa Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}.
P29972 AQP1 T239 psp Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Channel-like integral membrane protein of 28 kDa) (Urine water channel) Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053). {ECO:0000269|PubMed:1373524, ECO:0000269|PubMed:16682607, ECO:0000269|PubMed:17012249, ECO:0000269|PubMed:19273840, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:33028705, ECO:0000269|PubMed:35835865, ECO:0000269|PubMed:36949749, ECO:0000269|PubMed:8584435, ECO:0000269|PubMed:8703053}.
P31431 SDC4 S97 ochoa Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein) Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). {ECO:0000269|PubMed:22660413}.
P35368 ADRA1B S470 ochoa Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.
P37802 TAGLN2 S83 psp Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) None
P42166 TMPO S59 ochoa Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
P43490 NAMPT S472 ochoa Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.
P48681 NES S1521 ochoa Nestin Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P50402 EMD S29 ochoa Emerin Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}.
P51788 CLCN2 S76 psp Chloride channel protein 2 (ClC-2) Voltage-gated and osmosensitive chloride channel. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Displays inward rectification currents activated upon membrane hyperpolarization and extracellular hypotonicity (PubMed:16155254, PubMed:17567819, PubMed:19191339, PubMed:23632988, PubMed:29403011, PubMed:29403012, PubMed:36964785, PubMed:38345841). Contributes to chloride conductance involved in neuron excitability. In hippocampal neurons, generates a significant part of resting membrane conductance and provides an additional chloride efflux pathway to prevent chloride accumulation in dendrites upon GABA receptor activation. In glia, associates with the auxiliary subunit HEPACAM/GlialCAM at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux buffering extracellular chloride and potassium concentrations (PubMed:19191339, PubMed:22405205, PubMed:23707145). Regulates aldosterone production in adrenal glands. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated calcium channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012). Contributes to chloride conductance in retinal pigment epithelium involved in phagocytosis of shed photoreceptor outer segments and photoreceptor renewal (PubMed:36964785). Conducts chloride currents at the basolateral membrane of epithelial cells with a role in chloride reabsorption rather than secretion (By similarity) (PubMed:16155254). Permeable to small monovalent anions with chloride > thiocyanate > bromide > nitrate > iodide ion selectivity (By similarity) (PubMed:29403012). {ECO:0000250|UniProtKB:P35525, ECO:0000250|UniProtKB:Q9R0A1, ECO:0000269|PubMed:16155254, ECO:0000269|PubMed:17567819, ECO:0000269|PubMed:19191339, ECO:0000269|PubMed:22405205, ECO:0000269|PubMed:23632988, ECO:0000269|PubMed:23707145, ECO:0000269|PubMed:29403011, ECO:0000269|PubMed:29403012, ECO:0000269|PubMed:36964785, ECO:0000269|PubMed:38345841}.
P55082 MFAP3 S334 ochoa Microfibril-associated glycoprotein 3 Component of the elastin-associated microfibrils.
P55347 PKNOX1 S33 ochoa Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1) Activates transcription in the presence of PBX1A and HOXA1. {ECO:0000250|UniProtKB:O70477}.
P56524 HDAC4 S611 ochoa Histone deacetylase 4 (HD4) (EC 3.5.1.98) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.
P78312 FAM193A S965 ochoa Protein FAM193A (Protein IT14) None
P98161 PKD1 S916 psp Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein) Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Both PKD1 and PKD2 are required for channel activity (PubMed:27214281). Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Likely to be involved with polycystin-1-interacting protein 1 in the detection, sequestration and exocytosis of senescent mitochondria (PubMed:37681898). {ECO:0000250|UniProtKB:O08852, ECO:0000269|PubMed:12482949, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:37681898}.
P98175 RBM10 S797 ochoa RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}.
Q00341 HDLBP S804 ochoa Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
Q00587 CDC42EP1 S180 ochoa Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}.
Q05397 PTK2 S390 ochoa Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}.
Q08379 GOLGA2 S981 ochoa Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940, ECO:0000305|PubMed:26363069}.
Q13492 PICALM S20 ochoa Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.
Q14318 FKBP8 S323 ochoa Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796, ECO:0000269|PubMed:28169297}.
Q14677 CLINT1 S282 ochoa Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}.
Q14692 BMS1 S403 ochoa Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}.
Q14978 NOLC1 S643 ochoa Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}.
Q15233 NONO S212 ochoa Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}.
Q15276 RABEP1 S377 ochoa Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}.
Q15424 SAFB S761 ochoa Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}.
Q15545 TAF7 S34 ochoa Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}.
Q15637 SF1 S268 ochoa Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}.
Q17RH5 RAPGEF2 S921 psp Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (Neural RAP guanine nucleotide exchange protein) (PDZ domain-containing guanine nucleotide exchange factor 1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) None
Q5JSZ5 PRRC2B S1153 ochoa Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) None
Q5T035 FAM120A2P S68 ochoa Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene) None
Q6DN90 IQSEC1 S253 ochoa IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}.
Q6ZU80 CEP128 S298 ochoa Centrosomal protein of 128 kDa (Cep128) None
Q6ZV73 FGD6 S1195 ochoa FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.
Q711Q0 CEFIP S816 ochoa Cardiac-enriched FHL2-interacting protein Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}.
Q7Z417 NUFIP2 S607 ochoa FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) Binds RNA. {ECO:0000269|PubMed:12837692}.
Q86UU1 PHLDB1 S47 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86VP1 TAX1BP1 S683 ochoa Tax1-binding protein 1 (TRAF6-binding protein) Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}.
Q8IUD2 ERC1 S251 ochoa ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}.
Q8N392 ARHGAP18 S209 ochoa Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}.
Q8N4C8 MINK1 S1088 ochoa Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Q8N6F7 GCSAM S102 ochoa Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL) Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}.
Q8N6R0 METTL13 S269 ochoa eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation (PubMed:30143613, PubMed:30612740). Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' (PubMed:30143613). Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' (PubMed:30143613, PubMed:30612740). Has no activity towards core histones H2A, H2B, H3 and H4 (PubMed:30612740). {ECO:0000269|PubMed:30143613, ECO:0000269|PubMed:30612740}.
Q8NCN2 ZBTB34 S207 ochoa Zinc finger and BTB domain-containing protein 34 May be a transcriptional repressor. {ECO:0000269|PubMed:16718364}.
Q8NDX1 PSD4 S413 ochoa PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}.
Q8TB24 RIN3 S875 ochoa Ras and Rab interactor 3 (Ras interaction/interference protein 3) Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:21586568}.
Q8TEW0 PARD3 S962 ochoa|psp Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}.
Q8TEW8 PARD3B S780 ochoa Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q8TF76 HASPIN S243 psp Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}.
Q92575 UBXN4 S330 ochoa UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). {ECO:0000269|PubMed:16968747, ECO:0000269|PubMed:19822669}.
Q92736 RYR2 S2814 psp Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:17984046, ECO:0000269|PubMed:20056922, ECO:0000269|PubMed:27733687, ECO:0000269|PubMed:33536282}.
Q92966 SNAPC3 S69 ochoa snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF subunit beta) (Small nuclear RNA-activating complex polypeptide 3) (snRNA-activating protein complex 50 kDa subunit) (SNAPc 50 kDa subunit) Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}.
Q96B97 SH3KBP1 S181 ochoa SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}.
Q96HB5 CCDC120 S331 ochoa Coiled-coil domain-containing protein 120 Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}.
Q96KM6 ZNF512B S686 ochoa Zinc finger protein 512B Involved in transcriptional regulation by repressing gene expression (PubMed:39460621). Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:39460621). {ECO:0000269|PubMed:39460621}.
Q99683 MAP3K5 S1072 ochoa Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}.
Q9BXL7 CARD11 S655 psp Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}.
Q9H223 EHD4 S352 ochoa EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:17233914, PubMed:18331452). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (By similarity). {ECO:0000250|UniProtKB:Q9EQP2, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452}.
Q9H4L5 OSBPL3 S303 ochoa Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.
Q9HBI1 PARVB S39 ochoa Beta-parvin (Affixin) Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}.
Q9NQ55 PPAN S228 ochoa Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog) May have a role in cell growth.
Q9NVF7 FBXO28 S330 ochoa F-box only protein 28 Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}.
Q9NZB2 FAM120A S419 ochoa Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}.
Q9P2E9 RRBP1 S978 ochoa Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.
Q9P2G1 ANKIB1 S782 ochoa Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}.
Q9UBZ4 APEX2 S227 ochoa DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities (PubMed:16687656, PubMed:19443450, PubMed:32516598). Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (PubMed:16687656, PubMed:19443450). Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates (PubMed:16687656). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents (PubMed:16687656, PubMed:19443450). In the nucleus functions in the PCNA-dependent BER pathway (PubMed:11376153). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). {ECO:0000250|UniProtKB:Q68G58, ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:16687656, ECO:0000269|PubMed:19443450, ECO:0000269|PubMed:32516598}.
Q9UIF8 BAZ2B S1269 ochoa Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}.
Q9UIF9 BAZ2A S611 ochoa Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}.
Q9UKX2 MYH2 S670 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX3 MYH13 S668 ochoa Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}.
Q9ULD9 ZNF608 S440 ochoa Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}.
Q9ULJ8 PPP1R9A S460 psp Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A) Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity). {ECO:0000250}.
Q9Y289 SLC5A6 S585 ochoa Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6) Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:10329687, PubMed:15561972, PubMed:19211916, PubMed:20980265, PubMed:21570947, PubMed:22015582, PubMed:25809983, PubMed:25971966, PubMed:27904971, PubMed:28052864, PubMed:31754459). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (PubMed:10329687, PubMed:20980265). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:19211916). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983). {ECO:0000250|UniProtKB:Q5U4D8, ECO:0000269|PubMed:10329687, ECO:0000269|PubMed:15561972, ECO:0000269|PubMed:19211916, ECO:0000269|PubMed:20980265, ECO:0000269|PubMed:21570947, ECO:0000269|PubMed:22015582, ECO:0000269|PubMed:25809983, ECO:0000269|PubMed:25971966, ECO:0000269|PubMed:27904971, ECO:0000269|PubMed:28052864, ECO:0000269|PubMed:31754459}.
Q9Y2X9 ZNF281 S198 ochoa Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}.
Q9Y4G8 RAPGEF2 S933 ochoa Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}.
Q9Y4W6 AFG3L2 S53 ochoa Mitochondrial inner membrane m-AAA protease component AFG3L2 (EC 3.4.24.-) (EC 3.6.-.-) (AFG3-like protein 2) (Paraplegin-like protein) Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins, and which is essential for axonal and neuron development (PubMed:19748354, PubMed:28396416, PubMed:29932645, PubMed:30683687, PubMed:31327635, PubMed:37917749, PubMed:38157846). AFG3L2 possesses both ATPase and protease activities: the ATPase activity is required to unfold substrates, threading them into the internal proteolytic cavity for hydrolysis into small peptide fragments (PubMed:19748354, PubMed:31327635). The m-AAA protease carries out quality control in the inner membrane of the mitochondria by mediating degradation of mistranslated or misfolded polypeptides (PubMed:26504172, PubMed:30683687, PubMed:34718584). The m-AAA protease complex also promotes the processing and maturation of mitochondrial proteins, such as MRPL32/bL32m, PINK1 and SP7 (PubMed:22354088, PubMed:29932645, PubMed:30252181). Mediates protein maturation of the mitochondrial ribosomal subunit MRPL32/bL32m by catalyzing the cleavage of the presequence of MRPL32/bL32m prior to assembly into the mitochondrial ribosome (PubMed:29932645). Required for SPG7 maturation into its active mature form after SPG7 cleavage by mitochondrial-processing peptidase (MPP) (PubMed:30252181). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088). Acts as a regulator of calcium in neurons by mediating degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048, PubMed:28396416). Promotes the proteolytic degradation of GHITM upon hyperpolarization of mitochondria: progressive GHITM degradation leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2 (PubMed:35912435). Also acts as a regulator of mitochondrial glutathione homeostasis by mediating cleavage and degradation of SLC25A39 (PubMed:37917749, PubMed:38157846). SLC25A39 cleavage is prevented when SLC25A39 binds iron-sulfur (PubMed:37917749, PubMed:38157846). Involved in the regulation of OMA1-dependent processing of OPA1 (PubMed:17615298, PubMed:29545505, PubMed:30252181, PubMed:30683687, PubMed:32600459). May act by mediating processing of OMA1 precursor, participating in OMA1 maturation (PubMed:29545505). {ECO:0000269|PubMed:17615298, ECO:0000269|PubMed:19748354, ECO:0000269|PubMed:22354088, ECO:0000269|PubMed:26504172, ECO:0000269|PubMed:27642048, ECO:0000269|PubMed:28396416, ECO:0000269|PubMed:29545505, ECO:0000269|PubMed:29932645, ECO:0000269|PubMed:30252181, ECO:0000269|PubMed:30683687, ECO:0000269|PubMed:31327635, ECO:0000269|PubMed:32600459, ECO:0000269|PubMed:34718584, ECO:0000269|PubMed:35912435, ECO:0000269|PubMed:37917749, ECO:0000269|PubMed:38157846}.
Q9Y623 MYH4 S668 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
Q9NYB9 ABI2 S22 Sugiyama Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.
P30626 SRI S111 Sugiyama Sorcin (22 kDa protein) (CP-22) (CP22) (V19) Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}.
P04629 NTRK1 S732 Sugiyama High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA) Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1281417, PubMed:15488758, PubMed:17196528, PubMed:1849459, PubMed:1850821, PubMed:22649032, PubMed:27445338, PubMed:8325889). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250|UniProtKB:P35739, ECO:0000250|UniProtKB:Q3UFB7, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:17196528, ECO:0000269|PubMed:1849459, ECO:0000269|PubMed:1850821, ECO:0000269|PubMed:22649032, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:8155326, ECO:0000269|PubMed:8325889}.; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. {ECO:0000269|PubMed:15488758}.
Q8IZP0 ABI1 S22 Sugiyama Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.
Q9UHX1 PUF60 S232 Sugiyama Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}.
O14974 PPP1R12A S187 Sugiyama Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.
P31327 CPS1 S819 Sugiyama Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Q14697 GANAB S190 Sugiyama Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}.
Q9UBS4 DNAJB11 Y222 Sugiyama DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4) As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351). {ECO:0000269|PubMed:10827079, ECO:0000269|PubMed:15525676, ECO:0000269|PubMed:29706351}.
P31327 CPS1 S808 Sugiyama Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
P16234 PDGFRA S984 Sugiyama Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}.
P43405 SYK S54 Sugiyama Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}.
P20020 ATP2B1 S52 Sugiyama Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:35358416). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. {ECO:0000250|UniProtKB:G5E829, ECO:0000269|PubMed:29104511, ECO:0000269|PubMed:35358416}.
Q14432 PDE3A S273 Sugiyama cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}.
Q12802 AKAP13 S1294 Sugiyama A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q14164 IKBKE S603 Sugiyama Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}.
Q8WYL5 SSH1 S99 SIGNOR Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}.
P50851 LRBA S1725 Sugiyama Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}.
Q06124 PTPN11 S28 Sugiyama Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884). {ECO:0000250|UniProtKB:P35235, ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:19275884, ECO:0000269|PubMed:26742426, ECO:0000269|PubMed:28074573}.
Q9H093 NUAK2 S573 Sugiyama NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}.
O14893 GEMIN2 S126 Sugiyama Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9323129). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (PubMed:18984161, PubMed:9323129). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (PubMed:16314521, PubMed:21816274, PubMed:31799625). {ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9323129}.
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reactome_id name p -log10_p
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.000429 3.368
R-HSA-391160 Signal regulatory protein family interactions 0.000470 3.328
R-HSA-9768919 NPAS4 regulates expression of target genes 0.000392 3.407
R-HSA-9008059 Interleukin-37 signaling 0.000240 3.619
R-HSA-187042 TRKA activation by NGF 0.000811 3.091
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.000819 3.087
R-HSA-9927353 Co-inhibition by BTLA 0.001574 2.803
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.001594 2.797
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.001840 2.735
R-HSA-187015 Activation of TRKA receptors 0.003160 2.500
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.003888 2.410
R-HSA-9674415 Drug resistance of PDGFR mutants 0.008164 2.088
R-HSA-9674428 PDGFR mutants bind TKIs 0.008164 2.088
R-HSA-9674396 Imatinib-resistant PDGFR mutants 0.008164 2.088
R-HSA-9674403 Regorafenib-resistant PDGFR mutants 0.008164 2.088
R-HSA-9674401 Sunitinib-resistant PDGFR mutants 0.008164 2.088
R-HSA-9674404 Sorafenib-resistant PDGFR mutants 0.008164 2.088
R-HSA-418359 Reduction of cytosolic Ca++ levels 0.006923 2.160
R-HSA-114604 GPVI-mediated activation cascade 0.005521 2.258
R-HSA-210990 PECAM1 interactions 0.006063 2.217
R-HSA-877312 Regulation of IFNG signaling 0.007835 2.106
R-HSA-451927 Interleukin-2 family signaling 0.007041 2.152
R-HSA-9664417 Leishmania phagocytosis 0.009830 2.007
R-HSA-9664407 Parasite infection 0.009830 2.007
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.009830 2.007
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.010082 1.996
R-HSA-5357905 Regulation of TNFR1 signaling 0.010246 1.989
R-HSA-5602636 IKBKB deficiency causes SCID 0.024294 1.615
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 0.024294 1.615
R-HSA-167021 PLC-gamma1 signalling 0.040164 1.396
R-HSA-198745 Signalling to STAT3 0.040164 1.396
R-HSA-8865999 MET activates PTPN11 0.040164 1.396
R-HSA-187024 NGF-independant TRKA activation 0.063489 1.197
R-HSA-187706 Signalling to p38 via RIT and RIN 0.063489 1.197
R-HSA-9645135 STAT5 Activation 0.071139 1.148
R-HSA-177539 Autointegration results in viral DNA circles 0.071139 1.148
R-HSA-170984 ARMS-mediated activation 0.093717 1.028
R-HSA-3656237 Defective EXT2 causes exostoses 2 0.122976 0.910
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 0.122976 0.910
R-HSA-177504 Retrograde neurotrophin signalling 0.137252 0.862
R-HSA-9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 0.144303 0.841
R-HSA-9673770 Signaling by PDGFRA extracellular domain mutants 0.144303 0.841
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.144303 0.841
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.151297 0.820
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type 0.158235 0.801
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 0.158235 0.801
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.165116 0.782
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD 0.165116 0.782
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.057411 1.241
R-HSA-167161 HIV Transcription Initiation 0.061753 1.209
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.061753 1.209
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.205246 0.688
R-HSA-8874081 MET activates PTK2 signaling 0.230929 0.637
R-HSA-186763 Downstream signal transduction 0.037492 1.426
R-HSA-5620916 VxPx cargo-targeting to cilium 0.185426 0.732
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.130143 0.886
R-HSA-418885 DCC mediated attractive signaling 0.144303 0.841
R-HSA-9671555 Signaling by PDGFR in disease 0.198693 0.702
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.070758 1.150
R-HSA-198203 PI3K/AKT activation 0.101121 0.995
R-HSA-162592 Integration of provirus 0.115750 0.936
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.185426 0.732
R-HSA-73776 RNA Polymerase II Promoter Escape 0.066204 1.179
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.089925 1.046
R-HSA-186797 Signaling by PDGF 0.113052 0.947
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.061753 1.209
R-HSA-8949664 Processing of SMDT1 0.130143 0.886
R-HSA-169893 Prolonged ERK activation events 0.011984 1.921
R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling 0.198693 0.702
R-HSA-9758274 Regulation of NF-kappa B signaling 0.151297 0.820
R-HSA-202424 Downstream TCR signaling 0.195146 0.710
R-HSA-187687 Signalling to ERKs 0.047059 1.327
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.033903 1.470
R-HSA-8866376 Reelin signalling pathway 0.055777 1.254
R-HSA-5603029 IkBA variant leads to EDA-ID 0.063489 1.197
R-HSA-209560 NF-kB is activated and signals survival 0.115750 0.936
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.144303 0.841
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 0.158235 0.801
R-HSA-350054 Notch-HLH transcription pathway 0.205246 0.688
R-HSA-1169091 Activation of NF-kappaB in B cells 0.084999 1.071
R-HSA-933542 TRAF6 mediated NF-kB activation 0.218192 0.661
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.210020 0.678
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.021928 1.659
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.158235 0.801
R-HSA-180292 GAB1 signalosome 0.171941 0.765
R-HSA-9694614 Attachment and Entry 0.198693 0.702
R-HSA-5654710 PI-3K cascade:FGFR3 0.178711 0.748
R-HSA-912631 Regulation of signaling by CBL 0.178711 0.748
R-HSA-5654720 PI-3K cascade:FGFR4 0.185426 0.732
R-HSA-5654689 PI-3K cascade:FGFR1 0.205246 0.688
R-HSA-5654695 PI-3K cascade:FGFR2 0.224587 0.649
R-HSA-354192 Integrin signaling 0.041220 1.385
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.063489 1.197
R-HSA-450341 Activation of the AP-1 family of transcription factors 0.093717 1.028
R-HSA-912694 Regulation of IFNA/IFNB signaling 0.022514 1.648
R-HSA-3000170 Syndecan interactions 0.211745 0.674
R-HSA-9690406 Transcriptional regulation of testis differentiation 0.158235 0.801
R-HSA-170968 Frs2-mediated activation 0.130143 0.886
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.053435 1.272
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.113753 0.944
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.070758 1.150
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.015411 1.812
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.110568 0.956
R-HSA-175567 Integration of viral DNA into host genomic DNA 0.071139 1.148
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 0.013143 1.881
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 0.086252 1.064
R-HSA-112411 MAPK1 (ERK2) activation 0.093717 1.028
R-HSA-164843 2-LTR circle formation 0.101121 0.995
R-HSA-912526 Interleukin receptor SHC signaling 0.024024 1.619
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 0.115750 0.936
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 0.115750 0.936
R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection 0.115750 0.936
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.144303 0.841
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.178711 0.748
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.192086 0.717
R-HSA-5654706 FRS-mediated FGFR3 signaling 0.198693 0.702
R-HSA-5654712 FRS-mediated FGFR4 signaling 0.205246 0.688
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 0.218192 0.661
R-HSA-5654693 FRS-mediated FGFR1 signaling 0.224587 0.649
R-HSA-420029 Tight junction interactions 0.224587 0.649
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.134736 0.871
R-HSA-373752 Netrin-1 signaling 0.068468 1.165
R-HSA-446353 Cell-extracellular matrix interactions 0.144303 0.841
R-HSA-167044 Signalling to RAS 0.192086 0.717
R-HSA-8949215 Mitochondrial calcium ion transport 0.198693 0.702
R-HSA-9860931 Response of endothelial cells to shear stress 0.015273 1.816
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 0.122976 0.910
R-HSA-177929 Signaling by EGFR 0.097466 1.011
R-HSA-416482 G alpha (12/13) signalling events 0.157255 0.803
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.055959 1.252
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.018527 1.732
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.140295 0.853
R-HSA-162594 Early Phase of HIV Life Cycle 0.192086 0.717
R-HSA-166166 MyD88-independent TLR4 cascade 0.018527 1.732
R-HSA-167172 Transcription of the HIV genome 0.129229 0.889
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.072259 1.141
R-HSA-9706374 FLT3 signaling through SRC family kinases 0.048002 1.319
R-HSA-8941284 RUNX2 regulates chondrocyte maturation 0.055777 1.254
R-HSA-418886 Netrin mediated repulsion signals 0.078726 1.104
R-HSA-390696 Adrenoceptors 0.086252 1.064
R-HSA-425986 Sodium/Proton exchangers 0.086252 1.064
R-HSA-9683686 Maturation of spike protein 0.101121 0.995
R-HSA-110056 MAPK3 (ERK1) activation 0.101121 0.995
R-HSA-425561 Sodium/Calcium exchangers 0.115750 0.936
R-HSA-8951936 RUNX3 regulates p14-ARF 0.122976 0.910
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.122976 0.910
R-HSA-937039 IRAK1 recruits IKK complex 0.122976 0.910
R-HSA-418360 Platelet calcium homeostasis 0.033903 1.470
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.137252 0.862
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.144303 0.841
R-HSA-432047 Passive transport by Aquaporins 0.158235 0.801
R-HSA-1482801 Acyl chain remodelling of PS 0.224587 0.649
R-HSA-9855142 Cellular responses to mechanical stimuli 0.020565 1.687
R-HSA-166520 Signaling by NTRKs 0.048482 1.314
R-HSA-5578775 Ion homeostasis 0.016084 1.794
R-HSA-193639 p75NTR signals via NF-kB 0.144303 0.841
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.090426 1.044
R-HSA-432142 Platelet sensitization by LDL 0.015599 1.807
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.045081 1.346
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.225005 0.648
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.225005 0.648
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.225005 0.648
R-HSA-194138 Signaling by VEGF 0.108574 0.964
R-HSA-68875 Mitotic Prophase 0.098507 1.007
R-HSA-1433557 Signaling by SCF-KIT 0.066204 1.179
R-HSA-8964011 HDL clearance 0.071139 1.148
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.108465 0.965
R-HSA-389513 Co-inhibition by CTLA4 0.185426 0.732
R-HSA-2559580 Oxidative Stress Induced Senescence 0.014416 1.841
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.237220 0.625
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.013464 1.871
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.036370 1.439
R-HSA-9658195 Leishmania infection 0.102603 0.989
R-HSA-9824443 Parasitic Infection Pathways 0.102603 0.989
R-HSA-162587 HIV Life Cycle 0.174141 0.759
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.048482 1.314
R-HSA-76002 Platelet activation, signaling and aggregation 0.095268 1.021
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.171941 0.765
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.145903 0.836
R-HSA-877300 Interferon gamma signaling 0.058610 1.232
R-HSA-397014 Muscle contraction 0.042987 1.367
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 0.063489 1.197
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.015599 1.807
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.122976 0.910
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 0.165116 0.782
R-HSA-6807004 Negative regulation of MET activity 0.185426 0.732
R-HSA-112409 RAF-independent MAPK1/3 activation 0.205246 0.688
R-HSA-2160916 Hyaluronan degradation 0.224587 0.649
R-HSA-446652 Interleukin-1 family signaling 0.013464 1.871
R-HSA-6806834 Signaling by MET 0.036348 1.440
R-HSA-75893 TNF signaling 0.016084 1.794
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.198693 0.702
R-HSA-2980766 Nuclear Envelope Breakdown 0.100019 1.000
R-HSA-1059683 Interleukin-6 signaling 0.130143 0.886
R-HSA-5621481 C-type lectin receptors (CLRs) 0.205036 0.688
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.021046 1.677
R-HSA-1170546 Prolactin receptor signaling 0.137252 0.862
R-HSA-9856872 Malate-aspartate shuttle 0.137252 0.862
R-HSA-1480926 O2/CO2 exchange in erythrocytes 0.178711 0.748
R-HSA-9607240 FLT3 Signaling 0.059568 1.225
R-HSA-168898 Toll-like Receptor Cascades 0.095139 1.022
R-HSA-2559583 Cellular Senescence 0.081970 1.086
R-HSA-418346 Platelet homeostasis 0.016620 1.779
R-HSA-9009391 Extra-nuclear estrogen signaling 0.065231 1.186
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.043403 1.362
R-HSA-1433559 Regulation of KIT signaling 0.137252 0.862
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.178711 0.748
R-HSA-70635 Urea cycle 0.230929 0.637
R-HSA-450294 MAP kinase activation 0.110411 0.957
R-HSA-5576891 Cardiac conduction 0.120800 0.918
R-HSA-936837 Ion transport by P-type ATPases 0.118384 0.927
R-HSA-448424 Interleukin-17 signaling 0.134736 0.871
R-HSA-209543 p75NTR recruits signalling complexes 0.122976 0.910
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.045081 1.346
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.058540 1.233
R-HSA-73887 Death Receptor Signaling 0.053876 1.269
R-HSA-2586552 Signaling by Leptin 0.101121 0.995
R-HSA-9020558 Interleukin-2 signaling 0.108465 0.965
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.230929 0.637
R-HSA-9705683 SARS-CoV-2-host interactions 0.054248 1.266
R-HSA-1295596 Spry regulation of FGF signaling 0.144303 0.841
R-HSA-9734767 Developmental Cell Lineages 0.084312 1.074
R-HSA-6783589 Interleukin-6 family signaling 0.218192 0.661
R-HSA-1280215 Cytokine Signaling in Immune system 0.114751 0.940
R-HSA-109582 Hemostasis 0.215854 0.666
R-HSA-983712 Ion channel transport 0.092674 1.033
R-HSA-193704 p75 NTR receptor-mediated signalling 0.228013 0.642
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.037492 1.426
R-HSA-196780 Biotin transport and metabolism 0.144303 0.841
R-HSA-210993 Tie2 Signaling 0.171941 0.765
R-HSA-425410 Metal ion SLC transporters 0.077775 1.109
R-HSA-8854691 Interleukin-20 family signaling 0.211745 0.674
R-HSA-982772 Growth hormone receptor signaling 0.211745 0.674
R-HSA-449147 Signaling by Interleukins 0.017645 1.753
R-HSA-9694516 SARS-CoV-2 Infection 0.033004 1.481
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.075162 1.124
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.077775 1.109
R-HSA-2672351 Stimuli-sensing channels 0.076632 1.116
R-HSA-9824446 Viral Infection Pathways 0.232200 0.634
R-HSA-9700206 Signaling by ALK in cancer 0.075162 1.124
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.237220 0.625
R-HSA-75205 Dissolution of Fibrin Clot 0.108465 0.965
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.218192 0.661
R-HSA-8863678 Neurodegenerative Diseases 0.218192 0.661
R-HSA-1500931 Cell-Cell communication 0.059203 1.228
R-HSA-9679506 SARS-CoV Infections 0.048191 1.317
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.237220 0.625
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.162992 0.788
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.183350 0.737
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.121073 0.917
R-HSA-381038 XBP1(S) activates chaperone genes 0.183350 0.737
R-HSA-381070 IRE1alpha activates chaperones 0.201080 0.697
R-HSA-9020591 Interleukin-12 signaling 0.151558 0.819
R-HSA-447115 Interleukin-12 family signaling 0.186289 0.730
R-HSA-913531 Interferon Signaling 0.237922 0.624
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.243089 0.614
R-HSA-5654700 FRS-mediated FGFR2 signaling 0.243460 0.614
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.243460 0.614
R-HSA-5654708 Downstream signaling of activated FGFR3 0.249650 0.603
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.249650 0.603
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.249650 0.603
R-HSA-72163 mRNA Splicing - Major Pathway 0.254513 0.594
R-HSA-2424491 DAP12 signaling 0.255789 0.592
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.255789 0.592
R-HSA-5654716 Downstream signaling of activated FGFR4 0.255789 0.592
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.258209 0.588
R-HSA-5684996 MAPK1/MAPK3 signaling 0.261000 0.583
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.261235 0.583
R-HSA-182971 EGFR downregulation 0.261878 0.582
R-HSA-9820960 Respiratory syncytial virus (RSV) attachment and entry 0.261878 0.582
R-HSA-2129379 Molecules associated with elastic fibres 0.261878 0.582
R-HSA-162710 Synthesis of glycosylphosphatidylinositol (GPI) 0.261878 0.582
R-HSA-8963693 Aspartate and asparagine metabolism 0.261878 0.582
R-HSA-202403 TCR signaling 0.264262 0.578
R-HSA-389948 Co-inhibition by PD-1 0.267711 0.572
R-HSA-2024096 HS-GAG degradation 0.267918 0.572
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.267918 0.572
R-HSA-2871796 FCERI mediated MAPK activation 0.270317 0.568
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.273343 0.563
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.273909 0.562
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.273909 0.562
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.277266 0.557
R-HSA-72172 mRNA Splicing 0.278771 0.555
R-HSA-390522 Striated Muscle Contraction 0.279851 0.553
R-HSA-1482788 Acyl chain remodelling of PC 0.279851 0.553
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.279851 0.553
R-HSA-8964539 Glutamate and glutamine metabolism 0.279851 0.553
R-HSA-199220 Vitamin B5 (pantothenate) metabolism 0.279851 0.553
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.282421 0.549
R-HSA-162582 Signal Transduction 0.283471 0.547
R-HSA-909733 Interferon alpha/beta signaling 0.285445 0.544
R-HSA-1971475 Glycosaminoglycan-protein linkage region biosynthesis 0.285745 0.544
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.285745 0.544
R-HSA-2142845 Hyaluronan metabolism 0.285745 0.544
R-HSA-901042 Calnexin/calreticulin cycle 0.285745 0.544
R-HSA-168638 NOD1/2 Signaling Pathway 0.285745 0.544
R-HSA-9007101 Rab regulation of trafficking 0.291489 0.535
R-HSA-5654696 Downstream signaling of activated FGFR2 0.291591 0.535
R-HSA-5654687 Downstream signaling of activated FGFR1 0.291591 0.535
R-HSA-1482839 Acyl chain remodelling of PE 0.291591 0.535
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.291591 0.535
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.294510 0.531
R-HSA-2022928 HS-GAG biosynthesis 0.297389 0.527
R-HSA-74158 RNA Polymerase III Transcription 0.297389 0.527
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.297389 0.527
R-HSA-9682385 FLT3 signaling in disease 0.297389 0.527
R-HSA-8853659 RET signaling 0.297389 0.527
R-HSA-8941326 RUNX2 regulates bone development 0.297389 0.527
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.297528 0.526
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.297528 0.526
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.303141 0.518
R-HSA-933541 TRAF6 mediated IRF7 activation 0.303141 0.518
R-HSA-549127 SLC-mediated transport of organic cations 0.303141 0.518
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.306571 0.513
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.306571 0.513
R-HSA-382551 Transport of small molecules 0.306904 0.513
R-HSA-8875878 MET promotes cell motility 0.308845 0.510
R-HSA-1566948 Elastic fibre formation 0.308845 0.510
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.308845 0.510
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.309581 0.509
R-HSA-168249 Innate Immune System 0.313905 0.503
R-HSA-8964043 Plasma lipoprotein clearance 0.314504 0.502
R-HSA-201556 Signaling by ALK 0.314504 0.502
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.320116 0.495
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.320116 0.495
R-HSA-5260271 Diseases of Immune System 0.320116 0.495
R-HSA-9694548 Maturation of spike protein 0.325683 0.487
R-HSA-5663205 Infectious disease 0.328330 0.484
R-HSA-162906 HIV Infection 0.330060 0.481
R-HSA-9683701 Translation of Structural Proteins 0.331204 0.480
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.333555 0.477
R-HSA-5654743 Signaling by FGFR4 0.342113 0.466
R-HSA-8854214 TBC/RABGAPs 0.342113 0.466
R-HSA-9909396 Circadian clock 0.342488 0.465
R-HSA-2172127 DAP12 interactions 0.347501 0.459
R-HSA-3928662 EPHB-mediated forward signaling 0.347501 0.459
R-HSA-375280 Amine ligand-binding receptors 0.347501 0.459
R-HSA-202733 Cell surface interactions at the vascular wall 0.352401 0.453
R-HSA-8939211 ESR-mediated signaling 0.352401 0.453
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 0.352845 0.452
R-HSA-5654741 Signaling by FGFR3 0.352845 0.452
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.352845 0.452
R-HSA-1614558 Degradation of cysteine and homocysteine 0.352845 0.452
R-HSA-5683057 MAPK family signaling cascades 0.354658 0.450
R-HSA-75153 Apoptotic execution phase 0.358146 0.446
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.363404 0.440
R-HSA-381119 Unfolded Protein Response (UPR) 0.366118 0.436
R-HSA-9031628 NGF-stimulated transcription 0.368618 0.433
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.373791 0.427
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.373791 0.427
R-HSA-389661 Glyoxylate metabolism and glycine degradation 0.373791 0.427
R-HSA-162599 Late Phase of HIV Life Cycle 0.377814 0.423
R-HSA-109704 PI3K Cascade 0.378921 0.421
R-HSA-8856828 Clathrin-mediated endocytosis 0.380725 0.419
R-HSA-2871837 FCERI mediated NF-kB activation 0.383630 0.416
R-HSA-6794361 Neurexins and neuroligins 0.389057 0.410
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.389057 0.410
R-HSA-445355 Smooth Muscle Contraction 0.394064 0.404
R-HSA-388841 Regulation of T cell activation by CD28 family 0.394577 0.404
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.399029 0.399
R-HSA-9679191 Potential therapeutics for SARS 0.400934 0.397
R-HSA-5654736 Signaling by FGFR1 0.408840 0.388
R-HSA-193648 NRAGE signals death through JNK 0.408840 0.388
R-HSA-5621480 Dectin-2 family 0.413685 0.383
R-HSA-112399 IRS-mediated signalling 0.413685 0.383
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.418491 0.378
R-HSA-194441 Metabolism of non-coding RNA 0.423258 0.373
R-HSA-191859 snRNP Assembly 0.423258 0.373
R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism 0.423258 0.373
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.427986 0.369
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.427986 0.369
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.427986 0.369
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.427986 0.369
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.427986 0.369
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.427986 0.369
R-HSA-5633007 Regulation of TP53 Activity 0.429261 0.367
R-HSA-445717 Aquaporin-mediated transport 0.432676 0.364
R-HSA-2428928 IRS-related events triggered by IGF1R 0.432676 0.364
R-HSA-375165 NCAM signaling for neurite out-growth 0.437327 0.359
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.437327 0.359
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.441941 0.355
R-HSA-446728 Cell junction organization 0.442497 0.354
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.444643 0.352
R-HSA-5690714 CD22 mediated BCR regulation 0.446517 0.350
R-HSA-2428924 IGF1R signaling cascade 0.446517 0.350
R-HSA-74751 Insulin receptor signalling cascade 0.446517 0.350
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.446517 0.350
R-HSA-425407 SLC-mediated transmembrane transport 0.448633 0.348
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.451056 0.346
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.455558 0.341
R-HSA-196807 Nicotinate metabolism 0.460023 0.337
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.464452 0.333
R-HSA-5673001 RAF/MAP kinase cascade 0.465924 0.332
R-HSA-199991 Membrane Trafficking 0.470084 0.328
R-HSA-9678108 SARS-CoV-1 Infection 0.473077 0.325
R-HSA-204005 COPII-mediated vesicle transport 0.473202 0.325
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.473202 0.325
R-HSA-427413 NoRC negatively regulates rRNA expression 0.477523 0.321
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.477523 0.321
R-HSA-975634 Retinoid metabolism and transport 0.477523 0.321
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.481810 0.317
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.486061 0.313
R-HSA-8953897 Cellular responses to stimuli 0.488407 0.311
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 0.490278 0.310
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.494461 0.306
R-HSA-1980143 Signaling by NOTCH1 0.498609 0.302
R-HSA-9694635 Translation of Structural Proteins 0.502724 0.299
R-HSA-383280 Nuclear Receptor transcription pathway 0.506805 0.295
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.506805 0.295
R-HSA-9925561 Developmental Lineage of Pancreatic Acinar Cells 0.510853 0.292
R-HSA-9659379 Sensory processing of sound 0.510853 0.292
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.514868 0.288
R-HSA-5654738 Signaling by FGFR2 0.514868 0.288
R-HSA-9833482 PKR-mediated signaling 0.514868 0.288
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.517372 0.286
R-HSA-6806667 Metabolism of fat-soluble vitamins 0.518850 0.285
R-HSA-1630316 Glycosaminoglycan metabolism 0.519900 0.284
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.522800 0.282
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.530604 0.275
R-HSA-6794362 Protein-protein interactions at synapses 0.534458 0.272
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.538280 0.269
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.542072 0.266
R-HSA-1614635 Sulfur amino acid metabolism 0.542072 0.266
R-HSA-9645723 Diseases of programmed cell death 0.549562 0.260
R-HSA-1236974 ER-Phagosome pathway 0.553262 0.257
R-HSA-2682334 EPH-Ephrin signaling 0.567761 0.246
R-HSA-74752 Signaling by Insulin receptor 0.567761 0.246
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.567761 0.246
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.567761 0.246
R-HSA-2029481 FCGR activation 0.571312 0.243
R-HSA-9837999 Mitochondrial protein degradation 0.574835 0.240
R-HSA-68882 Mitotic Anaphase 0.577917 0.238
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.580221 0.236
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.585230 0.233
R-HSA-6807878 COPI-mediated anterograde transport 0.585230 0.233
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.588639 0.230
R-HSA-8878159 Transcriptional regulation by RUNX3 0.588639 0.230
R-HSA-190236 Signaling by FGFR 0.592019 0.228
R-HSA-3214847 HATs acetylate histones 0.595373 0.225
R-HSA-192105 Synthesis of bile acids and bile salts 0.595373 0.225
R-HSA-9020702 Interleukin-1 signaling 0.601998 0.220
R-HSA-1483255 PI Metabolism 0.605270 0.218
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.609343 0.215
R-HSA-9006931 Signaling by Nuclear Receptors 0.610264 0.214
R-HSA-196854 Metabolism of vitamins and cofactors 0.612031 0.213
R-HSA-5619507 Activation of HOX genes during differentiation 0.614926 0.211
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.614926 0.211
R-HSA-9833110 RSV-host interactions 0.614926 0.211
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 0.614926 0.211
R-HSA-9692914 SARS-CoV-1-host interactions 0.621233 0.207
R-HSA-1236975 Antigen processing-Cross presentation 0.627438 0.202
R-HSA-194068 Bile acid and bile salt metabolism 0.633541 0.198
R-HSA-1483249 Inositol phosphate metabolism 0.639546 0.194
R-HSA-68886 M Phase 0.644586 0.191
R-HSA-421270 Cell-cell junction organization 0.653124 0.185
R-HSA-2029485 Role of phospholipids in phagocytosis 0.654133 0.184
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.654133 0.184
R-HSA-8878166 Transcriptional regulation by RUNX2 0.665380 0.177
R-HSA-5653656 Vesicle-mediated transport 0.678840 0.168
R-HSA-162909 Host Interactions of HIV factors 0.678929 0.168
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.686796 0.163
R-HSA-114608 Platelet degranulation 0.689375 0.162
R-HSA-168256 Immune System 0.702836 0.153
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.706851 0.151
R-HSA-69278 Cell Cycle, Mitotic 0.712630 0.147
R-HSA-9018519 Estrogen-dependent gene expression 0.716395 0.145
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.718732 0.143
R-HSA-1483257 Phospholipid metabolism 0.732191 0.135
R-HSA-1257604 PIP3 activates AKT signaling 0.732191 0.135
R-HSA-1643685 Disease 0.740736 0.130
R-HSA-199977 ER to Golgi Anterograde Transport 0.743216 0.129
R-HSA-2187338 Visual phototransduction 0.743216 0.129
R-HSA-9609507 Protein localization 0.755667 0.122
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.757683 0.121
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.757683 0.121
R-HSA-3700989 Transcriptional Regulation by TP53 0.764000 0.117
R-HSA-9006936 Signaling by TGFB family members 0.769437 0.114
R-HSA-109581 Apoptosis 0.773228 0.112
R-HSA-212165 Epigenetic regulation of gene expression 0.774185 0.111
R-HSA-1280218 Adaptive Immune System 0.778425 0.109
R-HSA-1474244 Extracellular matrix organization 0.785088 0.105
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.789536 0.103
R-HSA-418555 G alpha (s) signalling events 0.791274 0.102
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.792999 0.101
R-HSA-9664433 Leishmania parasite growth and survival 0.794709 0.100
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.794709 0.100
R-HSA-5689880 Ub-specific processing proteases 0.794709 0.100
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.794709 0.100
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.794709 0.100
R-HSA-9006925 Intracellular signaling by second messengers 0.799330 0.097
R-HSA-611105 Respiratory electron transport 0.803052 0.095
R-HSA-3781865 Diseases of glycosylation 0.812620 0.090
R-HSA-69275 G2/M Transition 0.815706 0.088
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.818741 0.087
R-HSA-453274 Mitotic G2-G2/M phases 0.818741 0.087
R-HSA-5617833 Cilium Assembly 0.821726 0.085
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.830394 0.081
R-HSA-8953854 Metabolism of RNA 0.835941 0.078
R-HSA-428157 Sphingolipid metabolism 0.837296 0.077
R-HSA-948021 Transport to the Golgi and subsequent modification 0.838643 0.076
R-HSA-1483206 Glycerophospholipid biosynthesis 0.839978 0.076
R-HSA-5357801 Programmed Cell Death 0.843920 0.074
R-HSA-422475 Axon guidance 0.846404 0.072
R-HSA-1640170 Cell Cycle 0.852792 0.069
R-HSA-418990 Adherens junctions interactions 0.859914 0.066
R-HSA-2262752 Cellular responses to stress 0.860329 0.065
R-HSA-8878171 Transcriptional regulation by RUNX1 0.868937 0.061
R-HSA-9675108 Nervous system development 0.875303 0.058
R-HSA-72312 rRNA processing 0.875324 0.058
R-HSA-3247509 Chromatin modifying enzymes 0.877383 0.057
R-HSA-446203 Asparagine N-linked glycosylation 0.880861 0.055
R-HSA-157118 Signaling by NOTCH 0.883361 0.054
R-HSA-4839726 Chromatin organization 0.891790 0.050
R-HSA-5688426 Deubiquitination 0.897070 0.047
R-HSA-74160 Gene expression (Transcription) 0.902992 0.044
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.904357 0.044
R-HSA-416476 G alpha (q) signalling events 0.904515 0.044
R-HSA-6798695 Neutrophil degranulation 0.905634 0.043
R-HSA-73857 RNA Polymerase II Transcription 0.906143 0.043
R-HSA-212436 Generic Transcription Pathway 0.906947 0.042
R-HSA-1852241 Organelle biogenesis and maintenance 0.940209 0.027
R-HSA-597592 Post-translational protein modification 0.940816 0.026
R-HSA-8957322 Metabolism of steroids 0.942179 0.026
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.949857 0.022
R-HSA-388396 GPCR downstream signalling 0.960976 0.017
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.965053 0.015
R-HSA-9824439 Bacterial Infection Pathways 0.967051 0.015
R-HSA-1266738 Developmental Biology 0.968076 0.014
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.968142 0.014
R-HSA-71291 Metabolism of amino acids and derivatives 0.969193 0.014
R-HSA-5668914 Diseases of metabolism 0.975873 0.011
R-HSA-372790 Signaling by GPCR 0.977179 0.010
R-HSA-112316 Neuronal System 0.982932 0.007
R-HSA-500792 GPCR ligand binding 0.993888 0.003
R-HSA-392499 Metabolism of proteins 0.996959 0.001
R-HSA-556833 Metabolism of lipids 0.998808 0.001
R-HSA-9709957 Sensory Perception 0.999735 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
PRKD1PRKD1 0.829 0.175 -3 0.880
PIM3PIM3 0.827 0.225 -3 0.877
COTCOT 0.826 0.064 2 0.833
NDR2NDR2 0.824 0.150 -3 0.884
MAPKAPK2MAPKAPK2 0.824 0.180 -3 0.796
RSK3RSK3 0.823 0.273 -3 0.817
PRKD2PRKD2 0.823 0.184 -3 0.819
RSK2RSK2 0.823 0.238 -3 0.826
MAPKAPK3MAPKAPK3 0.823 0.162 -3 0.839
P70S6KBP70S6KB 0.822 0.299 -3 0.851
LATS2LATS2 0.821 0.121 -5 0.577
P90RSKP90RSK 0.821 0.233 -3 0.827
CDC7CDC7 0.820 0.058 1 0.831
NDR1NDR1 0.820 0.196 -3 0.879
GCN2GCN2 0.820 0.032 2 0.805
PIM1PIM1 0.819 0.248 -3 0.835
PRPKPRPK 0.818 0.033 -1 0.814
PKN3PKN3 0.815 0.140 -3 0.869
DSTYKDSTYK 0.815 0.013 2 0.840
CAMK1BCAMK1B 0.815 0.118 -3 0.896
CDKL1CDKL1 0.815 0.148 -3 0.865
MTORMTOR 0.813 0.017 1 0.786
ULK2ULK2 0.813 -0.006 2 0.778
CAMK2DCAMK2D 0.813 0.093 -3 0.898
CDKL5CDKL5 0.812 0.136 -3 0.862
NUAK2NUAK2 0.812 0.122 -3 0.865
P70S6KP70S6K 0.812 0.349 -3 0.786
AMPKA1AMPKA1 0.812 0.137 -3 0.890
RAF1RAF1 0.812 -0.012 1 0.841
CLK3CLK3 0.811 0.131 1 0.783
IKKBIKKB 0.811 -0.068 -2 0.765
PIM2PIM2 0.811 0.308 -3 0.805
RSK4RSK4 0.811 0.268 -3 0.793
TGFBR2TGFBR2 0.810 0.052 -2 0.826
TBK1TBK1 0.810 -0.014 1 0.762
ERK5ERK5 0.810 0.083 1 0.780
AMPKA2AMPKA2 0.810 0.151 -3 0.864
PKN2PKN2 0.809 0.135 -3 0.879
BMPR2BMPR2 0.809 -0.029 -2 0.878
PDHK1PDHK1 0.809 -0.058 1 0.839
SRPK2SRPK2 0.809 0.165 -3 0.748
MST4MST4 0.808 0.099 2 0.808
CAMK2GCAMK2G 0.808 -0.011 2 0.788
NLKNLK 0.808 0.036 1 0.777
NEK6NEK6 0.808 -0.018 -2 0.850
BCKDKBCKDK 0.808 -0.005 -1 0.780
NIKNIK 0.808 0.118 -3 0.908
PDHK4PDHK4 0.808 -0.139 1 0.849
PRKD3PRKD3 0.807 0.144 -3 0.792
MARK4MARK4 0.807 0.060 4 0.751
MOSMOS 0.807 -0.036 1 0.856
DAPK2DAPK2 0.807 0.116 -3 0.907
PKACGPKACG 0.807 0.133 -2 0.671
PKCDPKCD 0.807 0.128 2 0.764
HUNKHUNK 0.807 0.017 2 0.782
SRPK1SRPK1 0.807 0.115 -3 0.809
TSSK1TSSK1 0.806 0.080 -3 0.898
CAMLCKCAMLCK 0.806 0.113 -2 0.805
TSSK2TSSK2 0.806 0.051 -5 0.580
IKKEIKKE 0.806 -0.043 1 0.747
SGK3SGK3 0.806 0.232 -3 0.825
WNK1WNK1 0.806 0.071 -2 0.795
MSK2MSK2 0.805 0.120 -3 0.824
CAMK2BCAMK2B 0.805 0.099 2 0.761
NIM1NIM1 0.805 0.111 3 0.740
ATRATR 0.805 -0.019 1 0.810
NEK7NEK7 0.805 -0.063 -3 0.871
HIPK4HIPK4 0.805 0.092 1 0.725
MELKMELK 0.804 0.121 -3 0.854
SRPK3SRPK3 0.804 0.149 -3 0.791
CAMK4CAMK4 0.803 0.065 -3 0.862
CHK1CHK1 0.802 0.069 -3 0.863
CAMK2ACAMK2A 0.802 0.095 2 0.776
NUAK1NUAK1 0.802 0.074 -3 0.830
ULK1ULK1 0.802 -0.062 -3 0.827
NEK9NEK9 0.802 0.001 2 0.818
AURCAURC 0.801 0.075 -2 0.590
PAK3PAK3 0.801 0.109 -2 0.736
RIPK3RIPK3 0.801 -0.018 3 0.708
ICKICK 0.801 0.076 -3 0.888
MSK1MSK1 0.800 0.131 -3 0.823
PHKG1PHKG1 0.800 0.093 -3 0.874
WNK3WNK3 0.800 -0.003 1 0.822
PKACBPKACB 0.799 0.131 -2 0.611
LATS1LATS1 0.799 0.093 -3 0.888
SIKSIK 0.799 0.106 -3 0.822
SKMLCKSKMLCK 0.799 -0.001 -2 0.779
QSKQSK 0.798 0.087 4 0.730
IKKAIKKA 0.798 -0.069 -2 0.748
PKCAPKCA 0.798 0.119 2 0.703
AKT2AKT2 0.798 0.166 -3 0.745
MLK1MLK1 0.798 -0.071 2 0.790
PAK1PAK1 0.798 0.087 -2 0.721
MLK2MLK2 0.797 -0.020 2 0.811
MASTLMASTL 0.797 -0.106 -2 0.799
PKCGPKCG 0.796 0.091 2 0.699
QIKQIK 0.796 0.050 -3 0.884
PLK1PLK1 0.796 0.021 -2 0.850
DLKDLK 0.795 -0.036 1 0.833
CHAK2CHAK2 0.795 -0.061 -1 0.755
BRSK1BRSK1 0.795 0.083 -3 0.839
AURBAURB 0.795 0.078 -2 0.595
PKCBPKCB 0.795 0.074 2 0.714
GRK6GRK6 0.795 -0.039 1 0.842
GRK5GRK5 0.795 -0.140 -3 0.883
GRK1GRK1 0.795 -0.029 -2 0.751
DYRK2DYRK2 0.795 0.069 1 0.629
MNK2MNK2 0.794 0.038 -2 0.728
ANKRD3ANKRD3 0.794 -0.049 1 0.855
PKRPKR 0.794 0.100 1 0.821
ALK4ALK4 0.794 0.024 -2 0.828
MAPKAPK5MAPKAPK5 0.794 0.058 -3 0.810
RIPK1RIPK1 0.794 -0.031 1 0.814
ATMATM 0.793 -0.014 1 0.758
BRSK2BRSK2 0.793 0.043 -3 0.864
IRE1IRE1 0.793 -0.003 1 0.776
TGFBR1TGFBR1 0.792 0.017 -2 0.811
DCAMKL1DCAMKL1 0.792 0.127 -3 0.817
NEK2NEK2 0.792 0.016 2 0.799
PKG2PKG2 0.792 0.088 -2 0.604
AKT1AKT1 0.792 0.171 -3 0.763
PAK2PAK2 0.792 0.082 -2 0.716
IRE2IRE2 0.791 0.053 2 0.727
PKCHPKCH 0.791 0.080 2 0.700
TTBK2TTBK2 0.790 -0.060 2 0.680
FAM20CFAM20C 0.790 -0.006 2 0.534
BMPR1BBMPR1B 0.790 0.030 1 0.778
PAK6PAK6 0.789 0.054 -2 0.675
DNAPKDNAPK 0.789 0.051 1 0.698
MARK2MARK2 0.789 0.038 4 0.650
MNK1MNK1 0.789 0.055 -2 0.740
CLK4CLK4 0.789 0.093 -3 0.810
PRKXPRKX 0.788 0.120 -3 0.726
CAMK1GCAMK1G 0.788 0.101 -3 0.816
HIPK1HIPK1 0.788 0.117 1 0.645
MEK1MEK1 0.788 -0.035 2 0.842
CAMK1DCAMK1D 0.788 0.126 -3 0.743
MYLK4MYLK4 0.788 0.064 -2 0.722
MARK3MARK3 0.788 0.044 4 0.680
KISKIS 0.787 -0.021 1 0.619
PKCTPKCT 0.787 0.116 2 0.714
CLK2CLK2 0.787 0.147 -3 0.784
PLK4PLK4 0.787 0.037 2 0.636
CDK8CDK8 0.787 -0.032 1 0.598
CLK1CLK1 0.787 0.101 -3 0.782
VRK2VRK2 0.787 -0.028 1 0.859
ALK2ALK2 0.787 0.023 -2 0.825
PKACAPKACA 0.787 0.111 -2 0.561
YSK4YSK4 0.787 -0.048 1 0.775
BRAFBRAF 0.787 0.038 -4 0.779
GRK4GRK4 0.786 -0.128 -2 0.798
SNRKSNRK 0.786 -0.006 2 0.695
PKCZPKCZ 0.786 0.021 2 0.761
CDK18CDK18 0.786 0.019 1 0.522
HRIHRI 0.786 -0.010 -2 0.866
PERKPERK 0.786 -0.003 -2 0.871
MARK1MARK1 0.785 0.041 4 0.705
SSTKSSTK 0.785 0.091 4 0.725
CDK7CDK7 0.785 -0.016 1 0.596
ACVR2AACVR2A 0.785 -0.003 -2 0.833
AURAAURA 0.785 0.039 -2 0.572
PLK3PLK3 0.785 -0.019 2 0.740
CDK19CDK19 0.785 -0.022 1 0.556
ACVR2BACVR2B 0.784 -0.004 -2 0.840
SGK1SGK1 0.784 0.219 -3 0.682
SMMLCKSMMLCK 0.784 0.109 -3 0.869
DYRK1ADYRK1A 0.784 0.074 1 0.669
PHKG2PHKG2 0.783 0.078 -3 0.826
MEKK1MEKK1 0.783 0.011 1 0.814
AKT3AKT3 0.783 0.176 -3 0.693
WNK4WNK4 0.783 0.058 -2 0.786
MLK4MLK4 0.782 -0.043 2 0.721
HIPK3HIPK3 0.782 0.080 1 0.651
CHAK1CHAK1 0.782 -0.067 2 0.745
CDK13CDK13 0.781 -0.026 1 0.570
DAPK3DAPK3 0.781 0.152 -3 0.841
CRIKCRIK 0.781 0.365 -3 0.769
ZAKZAK 0.781 0.001 1 0.791
DCAMKL2DCAMKL2 0.780 0.062 -3 0.831
IRAK4IRAK4 0.780 0.045 1 0.798
GRK7GRK7 0.780 -0.003 1 0.782
DYRK1BDYRK1B 0.780 0.085 1 0.572
SMG1SMG1 0.780 -0.068 1 0.760
TLK1TLK1 0.780 0.004 -2 0.828
TLK2TLK2 0.780 -0.065 1 0.794
CDK5CDK5 0.780 0.000 1 0.616
NEK5NEK5 0.780 0.011 1 0.835
P38AP38A 0.779 -0.004 1 0.640
CAMKK1CAMKK1 0.779 0.048 -2 0.826
MLK3MLK3 0.779 -0.087 2 0.714
DYRK3DYRK3 0.779 0.110 1 0.649
CAMKK2CAMKK2 0.779 0.073 -2 0.813
CAMK1ACAMK1A 0.779 0.124 -3 0.709
JNK2JNK2 0.779 0.007 1 0.540
MPSK1MPSK1 0.779 0.103 1 0.767
CDK9CDK9 0.779 -0.014 1 0.581
DRAK1DRAK1 0.778 -0.026 1 0.757
HIPK2HIPK2 0.778 0.057 1 0.527
JNK3JNK3 0.778 -0.007 1 0.586
CHK2CHK2 0.777 0.107 -3 0.691
PRP4PRP4 0.777 0.033 -3 0.789
PKCIPKCI 0.777 0.077 2 0.726
PKN1PKN1 0.777 0.104 -3 0.790
DYRK4DYRK4 0.777 0.058 1 0.545
CDK12CDK12 0.776 -0.015 1 0.543
MEK5MEK5 0.776 -0.073 2 0.820
MST3MST3 0.775 0.048 2 0.795
P38BP38B 0.775 -0.011 1 0.570
LKB1LKB1 0.775 0.071 -3 0.877
CDK10CDK10 0.775 0.071 1 0.551
SBKSBK 0.775 0.109 -3 0.633
CDK14CDK14 0.774 0.021 1 0.569
BMPR1ABMPR1A 0.774 0.018 1 0.766
CDK17CDK17 0.774 -0.009 1 0.468
MRCKAMRCKA 0.774 0.170 -3 0.811
PAK5PAK5 0.773 0.037 -2 0.608
MEKK6MEKK6 0.772 0.102 1 0.795
CDK2CDK2 0.772 -0.045 1 0.645
MEKK3MEKK3 0.772 -0.101 1 0.798
MRCKBMRCKB 0.772 0.157 -3 0.796
CDK16CDK16 0.772 0.015 1 0.491
ERK2ERK2 0.772 -0.031 1 0.601
PKCEPKCE 0.771 0.084 2 0.679
ERK1ERK1 0.771 -0.032 1 0.558
ROCK2ROCK2 0.771 0.188 -3 0.838
MEKK2MEKK2 0.771 -0.057 2 0.800
PASKPASK 0.770 0.016 -3 0.894
DAPK1DAPK1 0.770 0.108 -3 0.832
TAO3TAO3 0.770 -0.013 1 0.785
P38GP38G 0.769 -0.017 1 0.459
CDK1CDK1 0.769 -0.045 1 0.547
NEK4NEK4 0.769 0.040 1 0.788
IRAK1IRAK1 0.769 -0.079 -1 0.683
PINK1PINK1 0.768 -0.145 1 0.776
BUB1BUB1 0.768 0.094 -5 0.593
TNIKTNIK 0.768 0.076 3 0.813
TAO2TAO2 0.768 0.009 2 0.810
HGKHGK 0.767 0.043 3 0.813
NEK1NEK1 0.767 0.069 1 0.807
PDK1PDK1 0.766 0.019 1 0.824
PBKPBK 0.766 0.128 1 0.759
MINKMINK 0.766 0.050 1 0.790
NEK11NEK11 0.766 -0.052 1 0.791
PAK4PAK4 0.766 0.029 -2 0.611
GRK2GRK2 0.765 -0.099 -2 0.677
NEK3NEK3 0.765 0.096 1 0.773
EEF2KEEF2K 0.765 0.020 3 0.769
DMPK1DMPK1 0.765 0.173 -3 0.795
GAKGAK 0.765 0.009 1 0.826
NEK8NEK8 0.765 -0.095 2 0.791
TTBK1TTBK1 0.764 -0.094 2 0.588
ERK7ERK7 0.764 0.027 2 0.546
MAP3K15MAP3K15 0.764 0.017 1 0.777
MOKMOK 0.764 0.128 1 0.667
MST2MST2 0.764 -0.057 1 0.805
P38DP38D 0.764 -0.006 1 0.481
LOKLOK 0.763 0.056 -2 0.755
CDK3CDK3 0.763 -0.013 1 0.487
GCKGCK 0.762 0.015 1 0.783
ROCK1ROCK1 0.762 0.184 -3 0.810
LRRK2LRRK2 0.762 0.011 2 0.819
MAKMAK 0.761 0.082 -2 0.640
MEK2MEK2 0.761 -0.030 2 0.822
YSK1YSK1 0.760 0.059 2 0.788
PKG1PKG1 0.760 0.059 -2 0.534
TAK1TAK1 0.759 -0.057 1 0.835
HPK1HPK1 0.759 0.027 1 0.760
CK1ECK1E 0.759 -0.045 -3 0.554
KHS1KHS1 0.759 0.059 1 0.772
CK2A2CK2A2 0.759 0.004 1 0.675
CDK4CDK4 0.758 0.013 1 0.528
MST1MST1 0.758 -0.030 1 0.787
GSK3BGSK3B 0.757 -0.073 4 0.328
VRK1VRK1 0.756 -0.051 2 0.800
KHS2KHS2 0.756 0.070 1 0.773
CDK6CDK6 0.755 -0.005 1 0.549
RIPK2RIPK2 0.753 -0.123 1 0.755
BIKEBIKE 0.753 0.087 1 0.711
PLK2PLK2 0.753 -0.059 -3 0.740
CK1G1CK1G1 0.753 -0.053 -3 0.537
TTKTTK 0.752 0.051 -2 0.845
CK1DCK1D 0.751 -0.048 -3 0.508
GSK3AGSK3A 0.751 -0.066 4 0.337
OSR1OSR1 0.751 0.014 2 0.813
JNK1JNK1 0.750 -0.041 1 0.530
STK33STK33 0.750 -0.087 2 0.589
GRK3GRK3 0.749 -0.106 -2 0.626
SLKSLK 0.748 -0.058 -2 0.692
CK1A2CK1A2 0.748 -0.045 -3 0.508
PDHK3_TYRPDHK3_TYR 0.748 0.092 4 0.821
HASPINHASPIN 0.745 0.037 -1 0.686
MYO3BMYO3B 0.745 0.018 2 0.794
CK2A1CK2A1 0.745 -0.026 1 0.645
AAK1AAK1 0.744 0.117 1 0.602
LIMK2_TYRLIMK2_TYR 0.743 0.154 -3 0.923
PKMYT1_TYRPKMYT1_TYR 0.743 0.123 3 0.811
ASK1ASK1 0.742 -0.017 1 0.767
TESK1_TYRTESK1_TYR 0.742 0.055 3 0.835
EPHA6EPHA6 0.741 0.114 -1 0.795
MAP2K4_TYRMAP2K4_TYR 0.741 0.019 -1 0.833
TAO1TAO1 0.739 -0.020 1 0.728
PINK1_TYRPINK1_TYR 0.738 0.032 1 0.835
MYO3AMYO3A 0.737 -0.020 1 0.759
MAP2K7_TYRMAP2K7_TYR 0.737 -0.043 2 0.831
MAP2K6_TYRMAP2K6_TYR 0.736 -0.043 -1 0.826
PDHK4_TYRPDHK4_TYR 0.736 -0.033 2 0.852
STLK3STLK3 0.735 -0.040 1 0.752
RETRET 0.735 0.046 1 0.815
ALPHAK3ALPHAK3 0.735 -0.024 -1 0.732
EPHB4EPHB4 0.734 0.039 -1 0.776
MST1RMST1R 0.734 0.024 3 0.799
TYK2TYK2 0.734 -0.008 1 0.822
LIMK1_TYRLIMK1_TYR 0.734 0.022 2 0.823
ABL2ABL2 0.733 0.062 -1 0.771
ROS1ROS1 0.733 0.018 3 0.746
BMPR2_TYRBMPR2_TYR 0.733 -0.050 -1 0.817
DDR1DDR1 0.732 0.031 4 0.761
PDHK1_TYRPDHK1_TYR 0.731 -0.096 -1 0.830
YANK3YANK3 0.730 -0.047 2 0.362
JAK2JAK2 0.729 -0.032 1 0.818
TNK2TNK2 0.729 0.066 3 0.766
JAK3JAK3 0.729 0.005 1 0.806
TYRO3TYRO3 0.729 -0.013 3 0.775
ABL1ABL1 0.729 0.054 -1 0.762
TNNI3K_TYRTNNI3K_TYR 0.729 0.075 1 0.832
CSF1RCSF1R 0.728 -0.035 3 0.782
PDGFRBPDGFRB 0.725 0.022 3 0.788
EPHB3EPHB3 0.725 0.003 -1 0.759
JAK1JAK1 0.725 0.025 1 0.772
FGRFGR 0.725 -0.041 1 0.864
FERFER 0.724 -0.071 1 0.885
INSRRINSRR 0.724 -0.016 3 0.719
FLT3FLT3 0.723 0.010 3 0.775
AXLAXL 0.722 0.013 3 0.769
EPHA4EPHA4 0.722 -0.028 2 0.725
YES1YES1 0.722 -0.038 -1 0.759
EPHB1EPHB1 0.722 -0.035 1 0.859
EPHB2EPHB2 0.721 -0.015 -1 0.756
NEK10_TYRNEK10_TYR 0.721 0.013 1 0.679
TNK1TNK1 0.721 0.014 3 0.751
TXKTXK 0.721 -0.015 1 0.828
TEKTEK 0.721 -0.010 3 0.710
SRMSSRMS 0.720 -0.053 1 0.864
FGFR1FGFR1 0.720 -0.012 3 0.756
FGFR2FGFR2 0.720 -0.030 3 0.768
PDGFRAPDGFRA 0.720 -0.027 3 0.784
LCKLCK 0.720 -0.018 -1 0.743
KDRKDR 0.719 -0.005 3 0.743
KITKIT 0.719 -0.061 3 0.781
EPHA1EPHA1 0.719 0.019 3 0.770
HCKHCK 0.719 -0.082 -1 0.739
BLKBLK 0.718 0.001 -1 0.749
TECTEC 0.718 -0.016 -1 0.671
DDR2DDR2 0.718 0.080 3 0.723
ITKITK 0.717 -0.048 -1 0.717
MERTKMERTK 0.717 -0.028 3 0.761
LTKLTK 0.716 -0.013 3 0.728
EPHA7EPHA7 0.716 -0.014 2 0.733
METMET 0.716 -0.037 3 0.783
ALKALK 0.715 -0.037 3 0.711
EPHA3EPHA3 0.715 -0.052 2 0.709
NTRK1NTRK1 0.714 -0.071 -1 0.779
BMXBMX 0.713 -0.037 -1 0.671
BTKBTK 0.711 -0.114 -1 0.688
NTRK2NTRK2 0.711 -0.068 3 0.735
PTK6PTK6 0.711 -0.113 -1 0.680
PTK2BPTK2B 0.710 -0.004 -1 0.714
FLT4FLT4 0.710 -0.056 3 0.714
EPHA5EPHA5 0.710 -0.025 2 0.719
FRKFRK 0.709 -0.065 -1 0.763
NTRK3NTRK3 0.708 -0.065 -1 0.750
INSRINSR 0.708 -0.071 3 0.697
FGFR3FGFR3 0.708 -0.065 3 0.739
FLT1FLT1 0.708 -0.076 -1 0.778
ERBB2ERBB2 0.708 -0.097 1 0.798
CK1ACK1A 0.706 -0.097 -3 0.412
WEE1_TYRWEE1_TYR 0.705 -0.086 -1 0.714
EPHA8EPHA8 0.704 -0.060 -1 0.748
MATKMATK 0.704 -0.064 -1 0.727
LYNLYN 0.703 -0.101 3 0.696
FYNFYN 0.703 -0.072 -1 0.719
EGFREGFR 0.701 -0.057 1 0.725
MUSKMUSK 0.699 -0.058 1 0.704
SRCSRC 0.696 -0.103 -1 0.728
EPHA2EPHA2 0.694 -0.063 -1 0.722
YANK2YANK2 0.694 -0.077 2 0.377
FGFR4FGFR4 0.694 -0.088 -1 0.736
CSKCSK 0.693 -0.137 2 0.742
IGF1RIGF1R 0.692 -0.089 3 0.632
PTK2PTK2 0.690 -0.069 -1 0.696
CK1G3CK1G3 0.690 -0.088 -3 0.363
SYKSYK 0.690 -0.076 -1 0.716
ERBB4ERBB4 0.684 -0.068 1 0.733
FESFES 0.680 -0.098 -1 0.658
ZAP70ZAP70 0.670 -0.060 -1 0.664
CK1G2CK1G2 0.667 -0.110 -3 0.456