Motif 704 (n=178)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1A5D9 | BICDL2 | S349 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
| A8K0Z3 | WASHC1 | S217 | ochoa | WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}. |
| A8MWX3 | WASH4P | S230 | ochoa | Putative WAS protein family homolog 4 (Protein FAM39CP) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| B9A064 | IGLL5 | S192 | ochoa | Immunoglobulin lambda-like polypeptide 5 (G lambda-1) (Germline immunoglobulin lambda 1) | None |
| C4AMC7 | WASH3P | S215 | ochoa | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
| H7C1D1 | None | S33 | ochoa | DUF4657 domain-containing protein | None |
| O00151 | PDLIM1 | S213 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00566 | MPHOSPH10 | S61 | ochoa | U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}. |
| O15061 | SYNM | S1241 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15240 | VGF | S420 | ochoa | Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] | [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [Neuroendocrine regulatory peptide-2]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Also stimulates feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity). {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [VGF-derived peptide TLQP-21]: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Also induces insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity). {ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Antimicrobial peptide VGF[554-577]]: Has bactericidal activity against M.luteus, and antifungal activity against P. Pastoris. {ECO:0000269|PubMed:23250050}. |
| O43148 | RNMT | S79 | psp | mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}. |
| O43164 | PJA2 | S242 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O60231 | DHX16 | S348 | ochoa | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) | Required for pre-mRNA splicing as a component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596). {ECO:0000269|PubMed:20423332, ECO:0000269|PubMed:20841358, ECO:0000269|PubMed:25296192, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:35263596, ECO:0000305|PubMed:33509932}. |
| O60318 | MCM3AP | S408 | ochoa | Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) | [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}. |
| O60716 | CTNND1 | S125 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75152 | ZC3H11A | S370 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75164 | KDM4A | S1019 | ochoa | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. |
| O75822 | EIF3J | S72 | ochoa | Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O95425 | SVIL | S134 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| P02545 | LMNA | S153 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02786 | TFRC | S24 | ochoa|psp | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity). {ECO:0000250|UniProtKB:Q62351, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.; FUNCTION: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762, ECO:0000269|PubMed:36779763}.; FUNCTION: (Microbial infection) Acts as a host entry factor for SARS-CoV, MERS-CoV and SARS-CoV-2 viruses that hijack the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762}. |
| P05198 | EIF2S1 | S161 | ochoa | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}. |
| P06400 | RB1 | S567 | psp | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P06748 | NPM1 | S195 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P06753 | TPM3 | S189 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P07951 | TPM2 | S188 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P0CF74 | IGLC6 | S84 | ochoa | Immunoglobulin lambda constant 6 (Ig lambda-6 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P0CG04 | IGLC1 | S84 | ochoa | Immunoglobulin lambda constant 1 (Ig lambda chain C region MGC) (Ig lambda-1 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P0DOY2 | IGLC2 | S84 | ochoa | Immunoglobulin lambda constant 2 (Ig lambda chain C region Kern) (Ig lambda chain C region NIG-64) (Ig lambda chain C region SH) (Ig lambda chain C region X) (Ig lambda-2 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P0DOY3 | IGLC3 | S84 | ochoa | Immunoglobulin lambda constant 3 (Ig lambda chain C region DOT) (Ig lambda chain C region NEWM) (Ig lambda-3 chain C regions) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P11055 | MYH3 | S1916 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11137 | MAP2 | S1362 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11171 | EPB41 | S104 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12270 | TPR | S361 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12270 | TPR | S1495 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12882 | MYH1 | S1898 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1919 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1275 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1476 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1894 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1915 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1478 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1720 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1896 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1917 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1918 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P16615 | ATP2A2 | S473 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P17661 | DES | S301 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P26038 | MSN | S384 | ochoa | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
| P28715 | ERCC5 | S705 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P29590 | PML | S561 | psp | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P35579 | MYH9 | S1243 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1326 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35609 | ACTN2 | T744 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35749 | MYH11 | S1722 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P37198 | NUP62 | S418 | ochoa | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}. |
| P39687 | ANP32A | S29 | ochoa | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}. |
| P45974 | USP5 | S159 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P46939 | UTRN | S286 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P49407 | ARRB1 | S163 | psp | Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2) | Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as a signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3. Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates in the recruitment of the ubiquitin-protein ligase to the receptor (PubMed:23886940). {ECO:0000250, ECO:0000269|PubMed:12464600, ECO:0000269|PubMed:14711824, ECO:0000269|PubMed:15475570, ECO:0000269|PubMed:15611106, ECO:0000269|PubMed:15671180, ECO:0000269|PubMed:15878855, ECO:0000269|PubMed:16144840, ECO:0000269|PubMed:16280323, ECO:0000269|PubMed:16378096, ECO:0000269|PubMed:16492667, ECO:0000269|PubMed:16709866, ECO:0000269|PubMed:18337459, ECO:0000269|PubMed:18419762, ECO:0000269|PubMed:19620252, ECO:0000269|PubMed:19643177, ECO:0000269|PubMed:22457824, ECO:0000269|PubMed:23341447, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:23886940}. |
| P49796 | RGS3 | S674 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P50395 | GDI2 | S382 | ochoa|psp | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P51149 | RAB7A | T168 | ochoa | Ras-related protein Rab-7a (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38538795). In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Also plays a central role in growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Required for vesicular trafficking and cell surface expression of ACE2 (PubMed:33147445). May play a role in PRPH neuronal intermediate filament assembly (By similarity). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:33147445, ECO:0000269|PubMed:38538795}. |
| P52565 | ARHGDIA | S24 | ochoa | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
| P54920 | NAPA | S26 | ochoa | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}. |
| P61421 | ATP6V0D1 | S283 | ochoa | V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1) | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:28296633, PubMed:30374053, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:30374053). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO:0000250|UniProtKB:P51863, ECO:0000250|UniProtKB:Q6PGV1, ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:30374053, ECO:0000269|PubMed:33065002}. |
| P78559 | MAP1A | S605 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P82094 | TMF1 | S136 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q01082 | SPTBN1 | S2122 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01484 | ANK2 | S3817 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01814 | ATP2B2 | S1163 | ochoa | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| Q02952 | AKAP12 | S915 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03188 | CENPC | S439 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q03252 | LMNB2 | Y319 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q04637 | EIF4G1 | S1199 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q05519 | SRSF11 | S231 | ochoa | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | May function in pre-mRNA splicing. |
| Q05682 | CALD1 | S518 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q07869 | PPARA | S179 | psp | Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}. |
| Q08043 | ACTN3 | T751 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q08378 | GOLGA3 | S389 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q12756 | KIF1A | S932 | ochoa | Kinesin-like protein KIF1A (EC 5.6.1.3) (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:33880452}. |
| Q12931 | TRAP1 | S76 | ochoa | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q13555 | CAMK2G | S26 | psp | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13557 | CAMK2D | S319 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13895 | BYSL | S55 | ochoa | Bystin | Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. {ECO:0000269|PubMed:17360433, ECO:0000269|PubMed:17381424}. |
| Q14839 | CHD4 | S1602 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
| Q15058 | KIF14 | S1044 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15911 | ZFHX3 | S2896 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q32MZ4 | LRRFIP1 | S491 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q5QJ74 | TBCEL | S342 | ochoa | Tubulin-specific chaperone cofactor E-like protein (EL) (Leucine-rich repeat-containing protein 35) | Acts as a regulator of tubulin stability. {ECO:0000269|PubMed:15728251}. |
| Q5QJE6 | DNTTIP2 | S145 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5T0W9 | FAM83B | S729 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5VZ18 | SHE | S341 | ochoa | SH2 domain-containing adapter protein E | None |
| Q6P2E9 | EDC4 | S107 | psp | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6PJT7 | ZC3H14 | S403 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6T4R5 | NHS | S993 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6VEQ5 | WASH2P | S217 | ochoa | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
| Q6ZU80 | CEP128 | S463 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q71F23 | CENPU | S190 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q86UL3 | GPAT4 | S98 | ochoa | Glycerol-3-phosphate acyltransferase 4 (EC 2.3.1.15) (1-acylglycerol-3-phosphate O-acyltransferase 6) (1-AGP acyltransferase 6) (1-AGPAT 6) (Acyl-CoA:glycerol-3-phosphate acyltransferase 4) (Lysophosphatidic acid acyltransferase zeta) (LPAAT-zeta) (Testis spermatogenesis apoptosis-related protein 7) (TSARG7) | Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:18238778). Active against both saturated and unsaturated long-chain fatty acyl-CoAs (PubMed:18238778). Protects cells against lipotoxicity (PubMed:30846318). {ECO:0000269|PubMed:18238778, ECO:0000269|PubMed:30846318}. |
| Q8IVF7 | FMNL3 | S960 | ochoa | Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. {ECO:0000250|UniProtKB:Q6NXC0, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22275430}. |
| Q8IWP9 | CCDC28A | S239 | ochoa | Coiled-coil domain-containing protein 28A (CCRL1AP) | None |
| Q8IY92 | SLX4 | S1170 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IYH5 | ZZZ3 | S113 | ochoa | ZZ-type zinc finger-containing protein 3 | Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}. |
| Q8NFC6 | BOD1L1 | S2124 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFJ5 | GPRC5A | S321 | ochoa | Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) | Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). {ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}. |
| Q8WWI1 | LMO7 | S545 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXE1 | ATRIP | S72 | psp | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q92499 | DDX1 | S632 | ochoa | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Q92830 | KAT2A | S372 | psp | Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97) | Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase, succinyltransferase or malonyltransferase, depending on the context (PubMed:29211711, PubMed:35995428). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755, PubMed:21131905). Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) (PubMed:21131905). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, MRE11, PPARGC1A, PLK4 and TBX5 (PubMed:16753578, PubMed:17301242, PubMed:27796307, PubMed:29174768, PubMed:38128537). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acts as a negative regulator of gluconeogenesis by mediating acetylation and subsequent inactivation of PPARGC1A (PubMed:16753578, PubMed:23142079). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). {ECO:0000250|UniProtKB:Q9JHD2, ECO:0000269|PubMed:16753578, ECO:0000269|PubMed:17301242, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:29174768, ECO:0000269|PubMed:29211711, ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837, ECO:0000269|PubMed:31542297, ECO:0000269|PubMed:35995428, ECO:0000269|PubMed:38128537}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. {ECO:0000269|PubMed:11384967}. |
| Q96HH4 | TMEM169 | S57 | ochoa | Transmembrane protein 169 | None |
| Q96HY6 | DDRGK1 | S114 | ochoa | DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1) | Component of the UFM1 ribosome E3 ligase (UREL) complex, a multiprotein complex that catalyzes ufmylation of endoplasmic reticulum-docked proteins (PubMed:30626644, PubMed:32160526, PubMed:35753586, PubMed:36121123, PubMed:36543799, PubMed:37595036, PubMed:37795761, PubMed:38383785, PubMed:38383789). The UREL complex plays a key role in ribosome recycling by mediating mono-ufmylation of the RPL26/uL24 subunit of the 60S ribosome following ribosome dissociation: ufmylation weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (PubMed:38383785, PubMed:38383789). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (PubMed:37595036, PubMed:38383785, PubMed:38383789). Within the UREL complex, DDRGK1 tethers the complex to the endoplasmic reticulum membrane to restrict its activity to endoplasmic reticulum-docked ribosomes and acts as an ufmylation 'reader': following RPL26/uL24 ufmylation, DDRGK1 specifically binds to ufmylated RPL26/uL24 via its UFIM motif, resulting in stable association between the 60S ribosome and the UREL complex, followed by dissociation of the 60S ribosome subunit from the endoplasmic reticulum membrane (PubMed:36121123, PubMed:37595036, PubMed:38383785, PubMed:38383789). The UREL complex is also involved in reticulophagy in response to endoplasmic reticulum stress by promoting ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (PubMed:32160526, PubMed:36543799). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (PubMed:28128204, PubMed:32160526). Acts as a regulator of immunity by promoting differentiation of B-cells into plasma cells: acts by promoting expansion of the endoplasmic reticulum and regulating the unfolded protein response (UPR) (By similarity). May also be required for TRIP4 ufmylation (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186). Required for stabilization and ufmylation of ATG9A (By similarity). {ECO:0000250|UniProtKB:Q80WW9, ECO:0000269|PubMed:23675531, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:28263186, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:35753586, ECO:0000269|PubMed:36121123, ECO:0000269|PubMed:36543799, ECO:0000269|PubMed:37595036, ECO:0000269|PubMed:37795761, ECO:0000269|PubMed:38383785, ECO:0000269|PubMed:38383789}. |
| Q96JG6 | VPS50 | S242 | ochoa | Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) | Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:25799061}. |
| Q96JH8 | RADIL | S540 | ochoa | Ras-associating and dilute domain-containing protein | Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}. |
| Q96JY6 | PDLIM2 | S239 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96M96 | FGD4 | S392 | ochoa | FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:15133042}. |
| Q96MU7 | YTHDC1 | S164 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q96T23 | RSF1 | S700 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99538 | LGMN | S368 | ochoa | Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1) | Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:23776206). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:23776206). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (PubMed:9872320). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules (By similarity). Required for normal degradation of internalized EGFR (By similarity). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). {ECO:0000250|UniProtKB:O89017, ECO:0000269|PubMed:23776206, ECO:0000269|PubMed:9872320}. |
| Q9BTC0 | DIDO1 | S525 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BUL8 | PDCD10 | S39 | psp | Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15) | Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q8VE70, ECO:0000269|PubMed:15543491, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:20332113, ECO:0000269|PubMed:27807006}. |
| Q9BV73 | CEP250 | S2390 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BVS4 | RIOK2 | S456 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BXK5 | BCL2L13 | S371 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BXS6 | NUSAP1 | S63 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9BXW9 | FANCD2 | S898 | psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BXW9 | FANCD2 | S1418 | psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BYX4 | IFIH1 | S301 | ochoa | Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines (PubMed:28594402, PubMed:32169843, PubMed:33727702). Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length) (PubMed:22160685). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and rhinovirus (PubMed:28606988). Detects coronavirus SARS-CoV-2 (PubMed:33440148, PubMed:33514628). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. {ECO:0000269|PubMed:14645903, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19656871, ECO:0000269|PubMed:21217758, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:22160685, ECO:0000269|PubMed:28594402, ECO:0000269|PubMed:28606988, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:33514628, ECO:0000269|PubMed:33727702}. |
| Q9C005 | DPY30 | S19 | ochoa | Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) | As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:19651892, ECO:0000269|PubMed:21335234}. |
| Q9GZY6 | LAT2 | S196 | ochoa | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
| Q9H0U9 | TSPYL1 | S140 | ochoa | Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) | None |
| Q9H2J7 | SLC6A15 | S25 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9HCM4 | EPB41L5 | S521 | ochoa | Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) | Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}. |
| Q9NQA3 | WASH6P | S199 | ochoa | WAS protein family homolog 6 (Protein FAM39A) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| Q9UBB9 | TFIP11 | S392 | ochoa | Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1) | Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}. |
| Q9UBU7 | DBF4 | S381 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UGU5 | HMGXB4 | S54 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
| Q9UHF7 | TRPS1 | S69 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UII2 | ATP5IF1 | S63 | ochoa|psp | ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) | Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403}. |
| Q9UKX2 | MYH2 | S1921 | ochoa|psp | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S1919 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9ULD2 | MTUS1 | S360 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9UNF1 | MAGED2 | S85 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9Y3B8 | REXO2 | S193 | ochoa | Oligoribonuclease, mitochondrial (EC 3.1.15.-) (RNA exonuclease 2 homolog) (Small fragment nuclease) | 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:23741365, PubMed:30926754, PubMed:31588022, PubMed:32365187). Binds and degrades longer oligonucleotides with a lower affinity (PubMed:30926754, PubMed:31588022, PubMed:32365187). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:30926754, PubMed:31588022, PubMed:32365187). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:Q9D8S4, ECO:0000269|PubMed:23741365, ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022, ECO:0000269|PubMed:32365187}.; FUNCTION: [Isoform 3]: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. {ECO:0000269|PubMed:10851236, ECO:0000269|PubMed:16682444}. |
| Q9Y490 | TLN1 | S423 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4B5 | MTCL1 | S790 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4G8 | RAPGEF2 | S1325 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y623 | MYH4 | S1919 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6A5 | TACC3 | S190 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| R4GMW8 | BIVM-ERCC5 | S1159 | ochoa | DNA excision repair protein ERCC-5 | None |
| P46777 | RPL5 | S224 | Sugiyama | Large ribosomal subunit protein uL18 (60S ribosomal protein L5) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:24120868}. |
| P35579 | MYH9 | S1892 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P25208 | NFYB | S95 | Sugiyama | Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. |
| Q07157 | TJP1 | S1360 | Sugiyama | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q9NXH9 | TRMT1 | S524 | Sugiyama | tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA methyltransferase 1) (hTRM1) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase) | Dimethylates a single guanine residue at position 26 of most nuclear- and mitochondrial-encoded tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:10982862, PubMed:28784718, PubMed:37204604, PubMed:39786990). tRNA guanine(26)-dimethylation is required for redox homeostasis and ensure proper cellular proliferation and oxidative stress survival (PubMed:28784718). {ECO:0000269|PubMed:10982862, ECO:0000269|PubMed:28784718, ECO:0000269|PubMed:37204604, ECO:0000269|PubMed:39786990}. |
| Q5QJE6 | DNTTIP2 | S703 | Sugiyama | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q6PKG0 | LARP1 | Y685 | Sugiyama | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q8N3D4 | EHBP1L1 | S1360 | Sugiyama | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| P30281 | CCND3 | S43 | Sugiyama | G1/S-specific cyclin-D3 | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120). {ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:8114739}. |
| Q9Y490 | TLN1 | S1891 | Sugiyama | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| P78371 | CCT2 | S101 | Sugiyama | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51812 | RPS6KA3 | S434 | Sugiyama | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| Q15349 | RPS6KA2 | S427 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q9UK32 | RPS6KA6 | S438 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| P35580 | MYH10 | S1699 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| Q92878 | RAD50 | S703 | Sugiyama | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q13554 | CAMK2B | S26 | Sugiyama | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13557 | CAMK2D | S26 | Sugiyama | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q9UQM7 | CAMK2A | S25 | Sugiyama | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q15418 | RPS6KA1 | S430 | Sugiyama | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| O43707 | ACTN4 | T756 | Sugiyama | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| P12814 | ACTN1 | T737 | Sugiyama | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P15735 | PHKG2 | S36 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (PubMed:35549678). {ECO:0000250|UniProtKB:P31325, ECO:0000269|PubMed:10487978, ECO:0000269|PubMed:35549678}. |
| Q16816 | PHKG1 | S32 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}. |
| Q8NG66 | NEK11 | S412 | Sugiyama | Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) | Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}. |
| P17980 | PSMC3 | S186 | Sugiyama | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| O60763 | USO1 | S883 | Sugiyama | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| P04920 | SLC4A2 | S56 | Sugiyama | Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-397014 | Muscle contraction | 4.045146e-10 | 9.393 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.292229e-09 | 8.889 |
| R-HSA-390522 | Striated Muscle Contraction | 3.243754e-08 | 7.489 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.428841e-06 | 5.615 |
| R-HSA-444257 | RSK activation | 9.927200e-06 | 5.003 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.904984e-05 | 4.720 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.904984e-05 | 4.720 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.904984e-05 | 4.720 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.896555e-06 | 5.051 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.901610e-05 | 4.721 |
| R-HSA-5578775 | Ion homeostasis | 1.230500e-05 | 4.910 |
| R-HSA-373753 | Nephrin family interactions | 1.321144e-05 | 4.879 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.830964e-05 | 4.548 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.798847e-05 | 4.553 |
| R-HSA-936837 | Ion transport by P-type ATPases | 2.595603e-05 | 4.586 |
| R-HSA-9620244 | Long-term potentiation | 3.660472e-05 | 4.436 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.778599e-05 | 4.321 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.778599e-05 | 4.321 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.778599e-05 | 4.321 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.778599e-05 | 4.321 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.614551e-05 | 4.179 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.268933e-04 | 3.897 |
| R-HSA-199920 | CREB phosphorylation | 1.761043e-04 | 3.754 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.050399e-04 | 3.516 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.938015e-04 | 3.405 |
| R-HSA-437239 | Recycling pathway of L1 | 5.138204e-04 | 3.289 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.536367e-04 | 3.257 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.536367e-04 | 3.257 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.533764e-04 | 3.257 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 7.744746e-04 | 3.111 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 7.354623e-04 | 3.133 |
| R-HSA-445355 | Smooth Muscle Contraction | 8.152782e-04 | 3.089 |
| R-HSA-373760 | L1CAM interactions | 9.241143e-04 | 3.034 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 9.569533e-04 | 3.019 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.003893e-03 | 2.998 |
| R-HSA-913531 | Interferon Signaling | 1.023225e-03 | 2.990 |
| R-HSA-8953854 | Metabolism of RNA | 1.126325e-03 | 2.948 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.217035e-03 | 2.915 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.217035e-03 | 2.915 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.305125e-03 | 2.884 |
| R-HSA-5673000 | RAF activation | 1.459991e-03 | 2.836 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.593306e-03 | 2.798 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.775984e-03 | 2.751 |
| R-HSA-111933 | Calmodulin induced events | 1.734860e-03 | 2.761 |
| R-HSA-111997 | CaM pathway | 1.734860e-03 | 2.761 |
| R-HSA-5576891 | Cardiac conduction | 1.853440e-03 | 2.732 |
| R-HSA-1640170 | Cell Cycle | 2.380984e-03 | 2.623 |
| R-HSA-2262752 | Cellular responses to stress | 2.474545e-03 | 2.607 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.667860e-03 | 2.574 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.667860e-03 | 2.574 |
| R-HSA-9664407 | Parasite infection | 2.667860e-03 | 2.574 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.762355e-03 | 2.559 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.937929e-03 | 2.532 |
| R-HSA-111996 | Ca-dependent events | 2.978052e-03 | 2.526 |
| R-HSA-774815 | Nucleosome assembly | 3.659834e-03 | 2.437 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.659834e-03 | 2.437 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.292570e-03 | 2.482 |
| R-HSA-198753 | ERK/MAPK targets | 3.672355e-03 | 2.435 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.659834e-03 | 2.437 |
| R-HSA-983712 | Ion channel transport | 3.325835e-03 | 2.478 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.690310e-03 | 2.433 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 4.080189e-03 | 2.389 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.198333e-03 | 2.377 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.308317e-03 | 2.366 |
| R-HSA-9675108 | Nervous system development | 5.075508e-03 | 2.295 |
| R-HSA-68875 | Mitotic Prophase | 5.204167e-03 | 2.284 |
| R-HSA-3371571 | HSF1-dependent transactivation | 5.326202e-03 | 2.274 |
| R-HSA-3371556 | Cellular response to heat stress | 5.390368e-03 | 2.268 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 5.966074e-03 | 2.224 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.007989e-03 | 2.096 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 7.436509e-03 | 2.129 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 7.076064e-03 | 2.150 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 7.052029e-03 | 2.152 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 7.539474e-03 | 2.123 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.060113e-03 | 2.151 |
| R-HSA-422475 | Axon guidance | 7.029169e-03 | 2.153 |
| R-HSA-418360 | Platelet calcium homeostasis | 8.300588e-03 | 2.081 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 8.300588e-03 | 2.081 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 8.836025e-03 | 2.054 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 8.904499e-03 | 2.050 |
| R-HSA-112043 | PLC beta mediated events | 9.111993e-03 | 2.040 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.689260e-03 | 2.014 |
| R-HSA-373755 | Semaphorin interactions | 1.003484e-02 | 1.998 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 1.051815e-02 | 1.978 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 1.160731e-02 | 1.935 |
| R-HSA-112040 | G-protein mediated events | 1.205759e-02 | 1.919 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.260110e-02 | 1.900 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.268446e-02 | 1.897 |
| R-HSA-166520 | Signaling by NTRKs | 1.391274e-02 | 1.857 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.493083e-02 | 1.826 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.720476e-02 | 1.764 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.720476e-02 | 1.764 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.555288e-02 | 1.808 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.816800e-02 | 1.741 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.816800e-02 | 1.741 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.816800e-02 | 1.741 |
| R-HSA-877300 | Interferon gamma signaling | 1.844209e-02 | 1.734 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.684538e-02 | 1.774 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.627374e-02 | 1.789 |
| R-HSA-9659379 | Sensory processing of sound | 1.962728e-02 | 1.707 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.022685e-02 | 1.694 |
| R-HSA-68886 | M Phase | 2.083450e-02 | 1.681 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.188926e-02 | 1.660 |
| R-HSA-162582 | Signal Transduction | 2.396264e-02 | 1.620 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 2.477495e-02 | 1.606 |
| R-HSA-114608 | Platelet degranulation | 2.638936e-02 | 1.579 |
| R-HSA-109582 | Hemostasis | 2.735694e-02 | 1.563 |
| R-HSA-173623 | Classical antibody-mediated complement activation | 2.776644e-02 | 1.556 |
| R-HSA-9031628 | NGF-stimulated transcription | 2.850132e-02 | 1.545 |
| R-HSA-112316 | Neuronal System | 2.954341e-02 | 1.530 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.009645e-02 | 1.521 |
| R-HSA-2559583 | Cellular Senescence | 3.032935e-02 | 1.518 |
| R-HSA-72649 | Translation initiation complex formation | 3.679319e-02 | 1.434 |
| R-HSA-2029481 | FCGR activation | 3.348508e-02 | 1.475 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.765163e-02 | 1.424 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.533413e-02 | 1.452 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 3.348508e-02 | 1.475 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.442142e-02 | 1.463 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.441623e-02 | 1.463 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.149430e-02 | 1.502 |
| R-HSA-2168880 | Scavenging of heme from plasma | 3.658331e-02 | 1.437 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.054642e-02 | 1.515 |
| R-HSA-9679506 | SARS-CoV Infections | 3.893088e-02 | 1.410 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.980285e-02 | 1.400 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 4.024606e-02 | 1.395 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 4.252338e-02 | 1.371 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.293356e-02 | 1.367 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 4.295898e-02 | 1.367 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.383330e-02 | 1.358 |
| R-HSA-1500931 | Cell-Cell communication | 4.485359e-02 | 1.348 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.593472e-02 | 1.338 |
| R-HSA-111885 | Opioid Signalling | 4.683966e-02 | 1.329 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.721929e-02 | 1.326 |
| R-HSA-209563 | Axonal growth stimulation | 5.671167e-02 | 1.246 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 5.671167e-02 | 1.246 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 5.671167e-02 | 1.246 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 5.748103e-02 | 1.240 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 6.370286e-02 | 1.196 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.316022e-02 | 1.274 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.241154e-02 | 1.281 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.316022e-02 | 1.274 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.848181e-02 | 1.233 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.671253e-02 | 1.246 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.955281e-02 | 1.305 |
| R-HSA-166786 | Creation of C4 and C2 activators | 5.057884e-02 | 1.296 |
| R-HSA-166663 | Initial triggering of complement | 6.274872e-02 | 1.202 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 5.148810e-02 | 1.288 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 5.445508e-02 | 1.264 |
| R-HSA-68882 | Mitotic Anaphase | 5.988301e-02 | 1.223 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.085804e-02 | 1.216 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 5.853441e-02 | 1.233 |
| R-HSA-450294 | MAP kinase activation | 4.785372e-02 | 1.320 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.830833e-02 | 1.316 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.501782e-02 | 1.259 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 6.766409e-02 | 1.170 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 6.766409e-02 | 1.170 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 8.919090e-02 | 1.050 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 6.689533e-02 | 1.175 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 6.689533e-02 | 1.175 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 7.013995e-02 | 1.154 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 7.013995e-02 | 1.154 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 7.677917e-02 | 1.115 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 7.677917e-02 | 1.115 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 8.017061e-02 | 1.096 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 8.708947e-02 | 1.060 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.711888e-02 | 1.173 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.711888e-02 | 1.173 |
| R-HSA-191650 | Regulation of gap junction activity | 6.766409e-02 | 1.170 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 9.061391e-02 | 1.043 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 8.708947e-02 | 1.060 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 8.017061e-02 | 1.096 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 7.677917e-02 | 1.115 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 7.677917e-02 | 1.115 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 9.417973e-02 | 1.026 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.849002e-02 | 1.105 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 7.343510e-02 | 1.134 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 8.360788e-02 | 1.078 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 6.766409e-02 | 1.170 |
| R-HSA-9636569 | Suppression of autophagy | 7.849002e-02 | 1.105 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 8.360788e-02 | 1.078 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 9.417973e-02 | 1.026 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.811264e-02 | 1.167 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.444687e-02 | 1.073 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 7.677917e-02 | 1.115 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.564494e-02 | 1.183 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 8.017061e-02 | 1.096 |
| R-HSA-199991 | Membrane Trafficking | 9.418948e-02 | 1.026 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 8.919090e-02 | 1.050 |
| R-HSA-69481 | G2/M Checkpoints | 8.612137e-02 | 1.065 |
| R-HSA-9843745 | Adipogenesis | 9.473414e-02 | 1.023 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 8.708947e-02 | 1.060 |
| R-HSA-381042 | PERK regulates gene expression | 8.708947e-02 | 1.060 |
| R-HSA-917937 | Iron uptake and transport | 7.421514e-02 | 1.130 |
| R-HSA-9658195 | Leishmania infection | 6.455708e-02 | 1.190 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.455708e-02 | 1.190 |
| R-HSA-1500620 | Meiosis | 9.620450e-02 | 1.017 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.588724e-02 | 1.120 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.588724e-02 | 1.120 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 7.677917e-02 | 1.115 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 8.919090e-02 | 1.050 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 8.919090e-02 | 1.050 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.952121e-02 | 1.100 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.564494e-02 | 1.183 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 8.055178e-02 | 1.094 |
| R-HSA-9013694 | Signaling by NOTCH4 | 7.215459e-02 | 1.142 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.005778e-02 | 1.155 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.588724e-02 | 1.120 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 8.360788e-02 | 1.078 |
| R-HSA-73886 | Chromosome Maintenance | 7.474420e-02 | 1.126 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 8.935166e-02 | 1.049 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 8.490255e-02 | 1.071 |
| R-HSA-977606 | Regulation of Complement cascade | 8.114670e-02 | 1.091 |
| R-HSA-72306 | tRNA processing | 7.205333e-02 | 1.142 |
| R-HSA-448424 | Interleukin-17 signaling | 6.417802e-02 | 1.193 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 7.343510e-02 | 1.134 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.233679e-02 | 1.084 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 9.778553e-02 | 1.010 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 9.778553e-02 | 1.010 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 9.976817e-02 | 1.001 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.014299e-01 | 0.994 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.014299e-01 | 0.994 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.051115e-01 | 0.978 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.051115e-01 | 0.978 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.051115e-01 | 0.978 |
| R-HSA-8982491 | Glycogen metabolism | 1.051115e-01 | 0.978 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.088289e-01 | 0.963 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.102233e-01 | 0.958 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 1.102233e-01 | 0.958 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.102233e-01 | 0.958 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.307725e-01 | 0.883 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.408693e-01 | 0.851 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.508495e-01 | 0.821 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.704653e-01 | 0.768 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.801035e-01 | 0.744 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.083548e-01 | 0.681 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.083548e-01 | 0.681 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.318145e-01 | 0.880 |
| R-HSA-72187 | mRNA 3'-end processing | 1.557804e-01 | 0.807 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.810076e-01 | 0.742 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.408693e-01 | 0.851 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.508495e-01 | 0.821 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.392983e-01 | 0.856 |
| R-HSA-5693538 | Homology Directed Repair | 2.010502e-01 | 0.697 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.846661e-01 | 0.734 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.185006e-01 | 0.661 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.704653e-01 | 0.768 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.014991e-01 | 0.696 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.240313e-01 | 0.906 |
| R-HSA-69236 | G1 Phase | 1.240313e-01 | 0.906 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.833980e-01 | 0.737 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.412580e-01 | 0.850 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.607144e-01 | 0.794 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.607144e-01 | 0.794 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.125809e-01 | 0.949 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.598530e-01 | 0.796 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 1.607144e-01 | 0.794 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.175551e-01 | 0.662 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 1.307725e-01 | 0.883 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.801035e-01 | 0.744 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.279087e-01 | 0.893 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.763296e-01 | 0.754 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.846661e-01 | 0.734 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.972730e-01 | 0.705 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.138768e-01 | 0.670 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.288737e-01 | 0.890 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.357475e-01 | 0.867 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.397065e-01 | 0.855 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 1.205576e-01 | 0.919 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.175551e-01 | 0.662 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.163661e-01 | 0.934 |
| R-HSA-1221632 | Meiotic synapsis | 1.598530e-01 | 0.796 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.846661e-01 | 0.734 |
| R-HSA-191859 | snRNP Assembly | 1.846661e-01 | 0.734 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.930582e-01 | 0.714 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.801035e-01 | 0.744 |
| R-HSA-9766229 | Degradation of CDH1 | 1.436904e-01 | 0.843 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.279087e-01 | 0.893 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.279087e-01 | 0.893 |
| R-HSA-425381 | Bicarbonate transporters | 1.508495e-01 | 0.821 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.083548e-01 | 0.681 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.930582e-01 | 0.714 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.268558e-01 | 0.897 |
| R-HSA-5635838 | Activation of SMO | 2.083548e-01 | 0.681 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.317217e-01 | 0.880 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.318145e-01 | 0.880 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.334139e-01 | 0.875 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.307725e-01 | 0.883 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.801035e-01 | 0.744 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.175551e-01 | 0.662 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.189216e-01 | 0.925 |
| R-HSA-9675135 | Diseases of DNA repair | 1.318145e-01 | 0.880 |
| R-HSA-157118 | Signaling by NOTCH | 1.893861e-01 | 0.723 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.408693e-01 | 0.851 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 1.704653e-01 | 0.768 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.660755e-01 | 0.780 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.083548e-01 | 0.681 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.014991e-01 | 0.696 |
| R-HSA-1483166 | Synthesis of PA | 1.763296e-01 | 0.754 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.775839e-01 | 0.751 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.508495e-01 | 0.821 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 2.175551e-01 | 0.662 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.680561e-01 | 0.775 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.557804e-01 | 0.807 |
| R-HSA-74160 | Gene expression (Transcription) | 1.231586e-01 | 0.910 |
| R-HSA-5688426 | Deubiquitination | 2.200504e-01 | 0.657 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.930582e-01 | 0.714 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.205576e-01 | 0.919 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.990470e-01 | 0.701 |
| R-HSA-166658 | Complement cascade | 1.248516e-01 | 0.904 |
| R-HSA-4839726 | Chromatin organization | 2.075984e-01 | 0.683 |
| R-HSA-1643685 | Disease | 1.609991e-01 | 0.793 |
| R-HSA-168256 | Immune System | 2.239423e-01 | 0.650 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.332155e-01 | 0.875 |
| R-HSA-162906 | HIV Infection | 1.641873e-01 | 0.785 |
| R-HSA-418346 | Platelet homeostasis | 1.605727e-01 | 0.794 |
| R-HSA-212436 | Generic Transcription Pathway | 2.165037e-01 | 0.665 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.453271e-01 | 0.838 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 1.846661e-01 | 0.734 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 2.185006e-01 | 0.661 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.801035e-01 | 0.744 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.562776e-01 | 0.806 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.896303e-01 | 0.722 |
| R-HSA-382551 | Transport of small molecules | 1.949493e-01 | 0.710 |
| R-HSA-75153 | Apoptotic execution phase | 1.318145e-01 | 0.880 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.661953e-01 | 0.779 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.098347e-01 | 0.678 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 1.350072e-01 | 0.870 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.360529e-01 | 0.866 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.360529e-01 | 0.866 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.360529e-01 | 0.866 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.099820e-01 | 0.678 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.690283e-01 | 0.772 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.718754e-01 | 0.765 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.040312e-01 | 0.690 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.718754e-01 | 0.765 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.040312e-01 | 0.690 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.130348e-01 | 0.672 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.577839e-01 | 0.802 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.130348e-01 | 0.672 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.804979e-01 | 0.744 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.892355e-01 | 0.723 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.088290e-01 | 0.680 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.179754e-01 | 0.928 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.239753e-01 | 0.650 |
| R-HSA-69206 | G1/S Transition | 2.251700e-01 | 0.647 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.266489e-01 | 0.645 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.266489e-01 | 0.645 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.266489e-01 | 0.645 |
| R-HSA-2028269 | Signaling by Hippo | 2.266489e-01 | 0.645 |
| R-HSA-168249 | Innate Immune System | 2.300572e-01 | 0.638 |
| R-HSA-204005 | COPII-mediated vesicle transport | 2.313320e-01 | 0.636 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.313320e-01 | 0.636 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.313868e-01 | 0.636 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.356205e-01 | 0.628 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.356205e-01 | 0.628 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.356205e-01 | 0.628 |
| R-HSA-5632684 | Hedgehog 'on' state | 2.356205e-01 | 0.628 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.356377e-01 | 0.628 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 2.356377e-01 | 0.628 |
| R-HSA-196791 | Vitamin D (calciferol) metabolism | 2.356377e-01 | 0.628 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.399135e-01 | 0.620 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.399135e-01 | 0.620 |
| R-HSA-1474165 | Reproduction | 2.436139e-01 | 0.613 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.445225e-01 | 0.612 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.445225e-01 | 0.612 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.445225e-01 | 0.612 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.445225e-01 | 0.612 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.485103e-01 | 0.605 |
| R-HSA-9909396 | Circadian clock | 2.498170e-01 | 0.602 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.528128e-01 | 0.597 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.533046e-01 | 0.596 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.533046e-01 | 0.596 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.533046e-01 | 0.596 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.533046e-01 | 0.596 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.533046e-01 | 0.596 |
| R-HSA-1980143 | Signaling by NOTCH1 | 2.571172e-01 | 0.590 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.571172e-01 | 0.590 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.571172e-01 | 0.590 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.590488e-01 | 0.587 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.619851e-01 | 0.582 |
| R-HSA-210991 | Basigin interactions | 2.619851e-01 | 0.582 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 2.619851e-01 | 0.582 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.633201e-01 | 0.580 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.657292e-01 | 0.576 |
| R-HSA-9824446 | Viral Infection Pathways | 2.674070e-01 | 0.573 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.700356e-01 | 0.569 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.705652e-01 | 0.568 |
| R-HSA-9833482 | PKR-mediated signaling | 2.743414e-01 | 0.562 |
| R-HSA-6807070 | PTEN Regulation | 2.748463e-01 | 0.561 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.786462e-01 | 0.555 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.790461e-01 | 0.554 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.790461e-01 | 0.554 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.790461e-01 | 0.554 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.790461e-01 | 0.554 |
| R-HSA-73894 | DNA Repair | 2.850954e-01 | 0.545 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.874290e-01 | 0.541 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.874290e-01 | 0.541 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.874290e-01 | 0.541 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.874290e-01 | 0.541 |
| R-HSA-3000170 | Syndecan interactions | 2.874290e-01 | 0.541 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.874614e-01 | 0.541 |
| R-HSA-429947 | Deadenylation of mRNA | 2.957148e-01 | 0.529 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.957148e-01 | 0.529 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.957148e-01 | 0.529 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.957148e-01 | 0.529 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.957148e-01 | 0.529 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.957148e-01 | 0.529 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.958438e-01 | 0.529 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.958438e-01 | 0.529 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.001352e-01 | 0.523 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.001352e-01 | 0.523 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.001352e-01 | 0.523 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.039049e-01 | 0.517 |
| R-HSA-3214842 | HDMs demethylate histones | 3.039049e-01 | 0.517 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.044223e-01 | 0.517 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.064644e-01 | 0.514 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.087048e-01 | 0.510 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.120002e-01 | 0.506 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.120002e-01 | 0.506 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.120002e-01 | 0.506 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 3.120002e-01 | 0.506 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.191642e-01 | 0.496 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.200018e-01 | 0.495 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.200018e-01 | 0.495 |
| R-HSA-77387 | Insulin receptor recycling | 3.279109e-01 | 0.484 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.279109e-01 | 0.484 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.279109e-01 | 0.484 |
| R-HSA-1989781 | PPARA activates gene expression | 3.286949e-01 | 0.483 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.286949e-01 | 0.483 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.300311e-01 | 0.481 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 3.317831e-01 | 0.479 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.350483e-01 | 0.475 |
| R-HSA-162587 | HIV Life Cycle | 3.350483e-01 | 0.475 |
| R-HSA-72086 | mRNA Capping | 3.357284e-01 | 0.474 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.357284e-01 | 0.474 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.357284e-01 | 0.474 |
| R-HSA-9711097 | Cellular response to starvation | 3.382242e-01 | 0.471 |
| R-HSA-72312 | rRNA processing | 3.396822e-01 | 0.469 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.434555e-01 | 0.464 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 3.434555e-01 | 0.464 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.434555e-01 | 0.464 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.434555e-01 | 0.464 |
| R-HSA-109581 | Apoptosis | 3.509177e-01 | 0.455 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.510932e-01 | 0.455 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.510932e-01 | 0.455 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.510932e-01 | 0.455 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.510932e-01 | 0.455 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.510932e-01 | 0.455 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.511750e-01 | 0.454 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.511750e-01 | 0.454 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.553776e-01 | 0.449 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.553776e-01 | 0.449 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.572557e-01 | 0.447 |
| R-HSA-1266738 | Developmental Biology | 3.579379e-01 | 0.446 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.586425e-01 | 0.445 |
| R-HSA-354192 | Integrin signaling | 3.661045e-01 | 0.436 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.661045e-01 | 0.436 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.661045e-01 | 0.436 |
| R-HSA-9930044 | Nuclear RNA decay | 3.661045e-01 | 0.436 |
| R-HSA-9733709 | Cardiogenesis | 3.661045e-01 | 0.436 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.679264e-01 | 0.434 |
| R-HSA-3214847 | HATs acetylate histones | 3.679264e-01 | 0.434 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.720887e-01 | 0.429 |
| R-HSA-70171 | Glycolysis | 3.720887e-01 | 0.429 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.720887e-01 | 0.429 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.734801e-01 | 0.428 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.734801e-01 | 0.428 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.734801e-01 | 0.428 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.803801e-01 | 0.420 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.807703e-01 | 0.419 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.807703e-01 | 0.419 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.807703e-01 | 0.419 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.807703e-01 | 0.419 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.879761e-01 | 0.411 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.879761e-01 | 0.411 |
| R-HSA-169911 | Regulation of Apoptosis | 3.879761e-01 | 0.411 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.879761e-01 | 0.411 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.886256e-01 | 0.410 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.886256e-01 | 0.410 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.887957e-01 | 0.410 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.887957e-01 | 0.410 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.950637e-01 | 0.403 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.950985e-01 | 0.403 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.950985e-01 | 0.403 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.950985e-01 | 0.403 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.950985e-01 | 0.403 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.009025e-01 | 0.397 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.021385e-01 | 0.396 |
| R-HSA-4641258 | Degradation of DVL | 4.021385e-01 | 0.396 |
| R-HSA-4641257 | Degradation of AXIN | 4.021385e-01 | 0.396 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4.021385e-01 | 0.396 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.021385e-01 | 0.396 |
| R-HSA-211000 | Gene Silencing by RNA | 4.049694e-01 | 0.393 |
| R-HSA-168255 | Influenza Infection | 4.075489e-01 | 0.390 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.090232e-01 | 0.388 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.090970e-01 | 0.388 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.130636e-01 | 0.384 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.130636e-01 | 0.384 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.159749e-01 | 0.381 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 4.159749e-01 | 0.381 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.159749e-01 | 0.381 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.159749e-01 | 0.381 |
| R-HSA-69541 | Stabilization of p53 | 4.159749e-01 | 0.381 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.227732e-01 | 0.374 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.227732e-01 | 0.374 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.227732e-01 | 0.374 |
| R-HSA-416476 | G alpha (q) signalling events | 4.237346e-01 | 0.373 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.251023e-01 | 0.372 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.251023e-01 | 0.372 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.251023e-01 | 0.372 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 4.290869e-01 | 0.367 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.294927e-01 | 0.367 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.294927e-01 | 0.367 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.294927e-01 | 0.367 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.294927e-01 | 0.367 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.294927e-01 | 0.367 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.294927e-01 | 0.367 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.361345e-01 | 0.360 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.361345e-01 | 0.360 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.361345e-01 | 0.360 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.361345e-01 | 0.360 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.361345e-01 | 0.360 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.361345e-01 | 0.360 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 4.361345e-01 | 0.360 |
| R-HSA-5663205 | Infectious disease | 4.396233e-01 | 0.357 |
| R-HSA-165159 | MTOR signalling | 4.426993e-01 | 0.354 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.448786e-01 | 0.352 |
| R-HSA-8854214 | TBC/RABGAPs | 4.491881e-01 | 0.348 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.491881e-01 | 0.348 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.491881e-01 | 0.348 |
| R-HSA-388396 | GPCR downstream signalling | 4.505469e-01 | 0.346 |
| R-HSA-68877 | Mitotic Prometaphase | 4.505860e-01 | 0.346 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.526837e-01 | 0.344 |
| R-HSA-70326 | Glucose metabolism | 4.526837e-01 | 0.344 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.536142e-01 | 0.343 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.556017e-01 | 0.341 |
| R-HSA-9907900 | Proteasome assembly | 4.556017e-01 | 0.341 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.556017e-01 | 0.341 |
| R-HSA-5683826 | Surfactant metabolism | 4.556017e-01 | 0.341 |
| R-HSA-9609690 | HCMV Early Events | 4.596498e-01 | 0.338 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.596498e-01 | 0.338 |
| R-HSA-446728 | Cell junction organization | 4.598185e-01 | 0.337 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.604265e-01 | 0.337 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.619411e-01 | 0.335 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.619411e-01 | 0.335 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.619411e-01 | 0.335 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.619411e-01 | 0.335 |
| R-HSA-9824272 | Somitogenesis | 4.619411e-01 | 0.335 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.681056e-01 | 0.330 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.682070e-01 | 0.330 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.682070e-01 | 0.330 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.682070e-01 | 0.330 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.699937e-01 | 0.328 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.716356e-01 | 0.326 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.744003e-01 | 0.324 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.757199e-01 | 0.323 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.805219e-01 | 0.318 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.805466e-01 | 0.318 |
| R-HSA-72172 | mRNA Splicing | 4.864485e-01 | 0.313 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.865726e-01 | 0.313 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.865726e-01 | 0.313 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.865726e-01 | 0.313 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.865726e-01 | 0.313 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.870172e-01 | 0.312 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.870172e-01 | 0.312 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.870172e-01 | 0.312 |
| R-HSA-194138 | Signaling by VEGF | 4.870172e-01 | 0.312 |
| R-HSA-5357801 | Programmed Cell Death | 4.893874e-01 | 0.310 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.925532e-01 | 0.308 |
| R-HSA-912446 | Meiotic recombination | 4.984644e-01 | 0.302 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.984644e-01 | 0.302 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.984644e-01 | 0.302 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.984644e-01 | 0.302 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.043072e-01 | 0.297 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.043072e-01 | 0.297 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.043072e-01 | 0.297 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.043072e-01 | 0.297 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 5.100822e-01 | 0.292 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.100822e-01 | 0.292 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.100822e-01 | 0.292 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.100822e-01 | 0.292 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.125993e-01 | 0.290 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.157904e-01 | 0.288 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.163937e-01 | 0.287 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.214323e-01 | 0.283 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.214323e-01 | 0.283 |
| R-HSA-418990 | Adherens junctions interactions | 5.268232e-01 | 0.278 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.270089e-01 | 0.278 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.270089e-01 | 0.278 |
| R-HSA-177929 | Signaling by EGFR | 5.270089e-01 | 0.278 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.325208e-01 | 0.274 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.341834e-01 | 0.272 |
| R-HSA-8951664 | Neddylation | 5.352478e-01 | 0.271 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.379689e-01 | 0.269 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.379689e-01 | 0.269 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.379689e-01 | 0.269 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.411737e-01 | 0.267 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.411737e-01 | 0.267 |
| R-HSA-186712 | Regulation of beta-cell development | 5.433538e-01 | 0.265 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.486762e-01 | 0.261 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.486762e-01 | 0.261 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.486762e-01 | 0.261 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.486762e-01 | 0.261 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.486762e-01 | 0.261 |
| R-HSA-8873719 | RAB geranylgeranylation | 5.486762e-01 | 0.261 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.486762e-01 | 0.261 |
| R-HSA-983189 | Kinesins | 5.486762e-01 | 0.261 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.486762e-01 | 0.261 |
| R-HSA-351202 | Metabolism of polyamines | 5.486762e-01 | 0.261 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.539370e-01 | 0.257 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.591367e-01 | 0.252 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.591367e-01 | 0.252 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.591367e-01 | 0.252 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.591367e-01 | 0.252 |
| R-HSA-9707616 | Heme signaling | 5.591367e-01 | 0.252 |
| R-HSA-418594 | G alpha (i) signalling events | 5.613114e-01 | 0.251 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.617082e-01 | 0.250 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.642762e-01 | 0.249 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.642762e-01 | 0.249 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.642762e-01 | 0.249 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.743770e-01 | 0.241 |
| R-HSA-372790 | Signaling by GPCR | 5.772801e-01 | 0.239 |
| R-HSA-69242 | S Phase | 5.783155e-01 | 0.238 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.793397e-01 | 0.237 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.793397e-01 | 0.237 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 5.793397e-01 | 0.237 |
| R-HSA-9758941 | Gastrulation | 5.815815e-01 | 0.235 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.848291e-01 | 0.233 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.890931e-01 | 0.230 |
| R-HSA-167172 | Transcription of the HIV genome | 5.890931e-01 | 0.230 |
| R-HSA-69306 | DNA Replication | 5.944606e-01 | 0.226 |
| R-HSA-73887 | Death Receptor Signaling | 5.976340e-01 | 0.224 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.986215e-01 | 0.223 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.986215e-01 | 0.223 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.986215e-01 | 0.223 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.986215e-01 | 0.223 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.986215e-01 | 0.223 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.033030e-01 | 0.219 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.033030e-01 | 0.219 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.045551e-01 | 0.219 |
| R-HSA-72766 | Translation | 6.057903e-01 | 0.218 |
| R-HSA-9610379 | HCMV Late Events | 6.070430e-01 | 0.217 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 6.079301e-01 | 0.216 |
| R-HSA-9609646 | HCMV Infection | 6.121029e-01 | 0.213 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.125036e-01 | 0.213 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.125036e-01 | 0.213 |
| R-HSA-4086398 | Ca2+ pathway | 6.125036e-01 | 0.213 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.125036e-01 | 0.213 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.125036e-01 | 0.213 |
| R-HSA-421270 | Cell-cell junction organization | 6.145974e-01 | 0.211 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.170240e-01 | 0.210 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 6.170240e-01 | 0.210 |
| R-HSA-380287 | Centrosome maturation | 6.214919e-01 | 0.207 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.214919e-01 | 0.207 |
| R-HSA-8852135 | Protein ubiquitination | 6.214919e-01 | 0.207 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 6.214919e-01 | 0.207 |
| R-HSA-5689603 | UCH proteinases | 6.259080e-01 | 0.203 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 6.302729e-01 | 0.200 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.345870e-01 | 0.198 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.345870e-01 | 0.198 |
| R-HSA-5619084 | ABC transporter disorders | 6.345870e-01 | 0.198 |
| R-HSA-4086400 | PCP/CE pathway | 6.345870e-01 | 0.198 |
| R-HSA-5619102 | SLC transporter disorders | 6.372033e-01 | 0.196 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.430658e-01 | 0.192 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.472314e-01 | 0.189 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.544170e-01 | 0.184 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.554183e-01 | 0.183 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.554183e-01 | 0.183 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.594405e-01 | 0.181 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.594405e-01 | 0.181 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.594405e-01 | 0.181 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.673455e-01 | 0.176 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.750679e-01 | 0.171 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.788620e-01 | 0.168 |
| R-HSA-156902 | Peptide chain elongation | 6.788620e-01 | 0.168 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.788620e-01 | 0.168 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.826120e-01 | 0.166 |
| R-HSA-597592 | Post-translational protein modification | 6.844735e-01 | 0.165 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.863185e-01 | 0.163 |
| R-HSA-202424 | Downstream TCR signaling | 6.863185e-01 | 0.163 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.899819e-01 | 0.161 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.899819e-01 | 0.161 |
| R-HSA-69275 | G2/M Transition | 6.920564e-01 | 0.160 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.963386e-01 | 0.157 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.971502e-01 | 0.157 |
| R-HSA-391251 | Protein folding | 6.971815e-01 | 0.157 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.971815e-01 | 0.157 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.971815e-01 | 0.157 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.007186e-01 | 0.154 |
| R-HSA-5617833 | Cilium Assembly | 7.021745e-01 | 0.154 |
| R-HSA-1280218 | Adaptive Immune System | 7.069567e-01 | 0.151 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.076702e-01 | 0.150 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.076702e-01 | 0.150 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.110855e-01 | 0.148 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.135837e-01 | 0.147 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.144611e-01 | 0.146 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.210951e-01 | 0.142 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.243544e-01 | 0.140 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.262706e-01 | 0.139 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.275757e-01 | 0.138 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.307597e-01 | 0.136 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.307597e-01 | 0.136 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.331724e-01 | 0.135 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.339066e-01 | 0.134 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.339066e-01 | 0.134 |
| R-HSA-192823 | Viral mRNA Translation | 7.370169e-01 | 0.133 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.400911e-01 | 0.131 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.431295e-01 | 0.129 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.431295e-01 | 0.129 |
| R-HSA-9833110 | RSV-host interactions | 7.431295e-01 | 0.129 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.461326e-01 | 0.127 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.520344e-01 | 0.124 |
| R-HSA-69239 | Synthesis of DNA | 7.520344e-01 | 0.124 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.549339e-01 | 0.122 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.605066e-01 | 0.119 |
| R-HSA-202403 | TCR signaling | 7.606322e-01 | 0.119 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.622439e-01 | 0.118 |
| R-HSA-8957322 | Metabolism of steroids | 7.674109e-01 | 0.115 |
| R-HSA-449147 | Signaling by Interleukins | 7.687232e-01 | 0.114 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.716363e-01 | 0.113 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.743077e-01 | 0.111 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.846863e-01 | 0.105 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.945901e-01 | 0.100 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.945901e-01 | 0.100 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.993707e-01 | 0.097 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.089220e-01 | 0.092 |
| R-HSA-6798695 | Neutrophil degranulation | 8.114962e-01 | 0.091 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.341382e-01 | 0.079 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.357849e-01 | 0.078 |
| R-HSA-392499 | Metabolism of proteins | 8.395564e-01 | 0.076 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.443552e-01 | 0.073 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.513016e-01 | 0.070 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.624097e-01 | 0.064 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.640236e-01 | 0.063 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.682815e-01 | 0.061 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.762749e-01 | 0.057 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.819823e-01 | 0.055 |
| R-HSA-1483257 | Phospholipid metabolism | 8.841752e-01 | 0.053 |
| R-HSA-195721 | Signaling by WNT | 8.873829e-01 | 0.052 |
| R-HSA-418555 | G alpha (s) signalling events | 8.926231e-01 | 0.049 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.926231e-01 | 0.049 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.975800e-01 | 0.047 |
| R-HSA-611105 | Respiratory electron transport | 9.011477e-01 | 0.045 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.068212e-01 | 0.042 |
| R-HSA-1474244 | Extracellular matrix organization | 9.176366e-01 | 0.037 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.541160e-01 | 0.020 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.859141e-01 | 0.006 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.891707e-01 | 0.005 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.956653e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.997308e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.998159e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.871 | 0.301 | 1 | 0.846 |
COT |
0.868 | 0.180 | 2 | 0.885 |
SRPK1 |
0.859 | 0.201 | -3 | 0.735 |
PIM3 |
0.855 | 0.097 | -3 | 0.812 |
WNK1 |
0.855 | 0.210 | -2 | 0.888 |
PKCD |
0.854 | 0.239 | 2 | 0.812 |
NLK |
0.853 | 0.154 | 1 | 0.832 |
CDKL1 |
0.852 | 0.123 | -3 | 0.777 |
CAMK1B |
0.852 | 0.088 | -3 | 0.835 |
PKN2 |
0.851 | 0.195 | -3 | 0.805 |
MLK1 |
0.851 | 0.171 | 2 | 0.836 |
PRPK |
0.851 | -0.029 | -1 | 0.865 |
MTOR |
0.851 | 0.016 | 1 | 0.795 |
ATR |
0.850 | 0.116 | 1 | 0.888 |
MST4 |
0.850 | 0.178 | 2 | 0.824 |
SRPK2 |
0.850 | 0.164 | -3 | 0.654 |
DSTYK |
0.850 | 0.087 | 2 | 0.893 |
RSK2 |
0.849 | 0.109 | -3 | 0.752 |
MOS |
0.849 | 0.035 | 1 | 0.860 |
PIM1 |
0.849 | 0.127 | -3 | 0.759 |
PKN3 |
0.849 | 0.108 | -3 | 0.795 |
GCN2 |
0.849 | -0.024 | 2 | 0.812 |
TSSK2 |
0.849 | 0.184 | -5 | 0.857 |
ULK2 |
0.848 | 0.038 | 2 | 0.796 |
CLK1 |
0.848 | 0.235 | -3 | 0.724 |
SKMLCK |
0.848 | 0.147 | -2 | 0.896 |
PRKD2 |
0.848 | 0.136 | -3 | 0.750 |
NUAK2 |
0.848 | 0.123 | -3 | 0.813 |
NIK |
0.848 | 0.163 | -3 | 0.849 |
MAPKAPK3 |
0.847 | 0.104 | -3 | 0.745 |
RAF1 |
0.847 | -0.017 | 1 | 0.843 |
MLK3 |
0.847 | 0.245 | 2 | 0.781 |
CDKL5 |
0.847 | 0.119 | -3 | 0.770 |
CDC7 |
0.847 | -0.012 | 1 | 0.830 |
NEK6 |
0.846 | 0.103 | -2 | 0.821 |
IKKB |
0.846 | -0.057 | -2 | 0.747 |
PKCB |
0.845 | 0.227 | 2 | 0.774 |
PKCG |
0.845 | 0.218 | 2 | 0.791 |
CAMLCK |
0.845 | 0.120 | -2 | 0.882 |
BMPR2 |
0.845 | -0.005 | -2 | 0.844 |
PKCA |
0.845 | 0.232 | 2 | 0.765 |
IRE1 |
0.845 | 0.194 | 1 | 0.844 |
CAMK2G |
0.844 | -0.048 | 2 | 0.825 |
CLK4 |
0.844 | 0.186 | -3 | 0.742 |
CHAK2 |
0.844 | 0.071 | -1 | 0.843 |
SRPK3 |
0.843 | 0.152 | -3 | 0.700 |
PRKD1 |
0.843 | 0.094 | -3 | 0.792 |
MNK2 |
0.842 | 0.173 | -2 | 0.838 |
PKCH |
0.842 | 0.213 | 2 | 0.771 |
GRK5 |
0.842 | -0.058 | -3 | 0.827 |
ERK5 |
0.842 | 0.044 | 1 | 0.776 |
CLK2 |
0.841 | 0.221 | -3 | 0.735 |
RIPK3 |
0.841 | 0.034 | 3 | 0.712 |
P90RSK |
0.841 | 0.060 | -3 | 0.752 |
TBK1 |
0.840 | -0.068 | 1 | 0.739 |
PAK1 |
0.840 | 0.118 | -2 | 0.849 |
TSSK1 |
0.840 | 0.129 | -3 | 0.846 |
MAPKAPK2 |
0.840 | 0.070 | -3 | 0.708 |
PDHK4 |
0.840 | -0.244 | 1 | 0.858 |
NDR1 |
0.840 | 0.032 | -3 | 0.802 |
P70S6KB |
0.840 | 0.065 | -3 | 0.769 |
RSK3 |
0.839 | 0.075 | -3 | 0.744 |
DAPK2 |
0.839 | 0.083 | -3 | 0.835 |
MNK1 |
0.839 | 0.180 | -2 | 0.840 |
NEK7 |
0.839 | -0.015 | -3 | 0.775 |
ICK |
0.839 | 0.082 | -3 | 0.810 |
NDR2 |
0.839 | -0.024 | -3 | 0.809 |
AURC |
0.838 | 0.152 | -2 | 0.727 |
GRK1 |
0.838 | 0.023 | -2 | 0.757 |
PAK6 |
0.838 | 0.169 | -2 | 0.787 |
GRK6 |
0.838 | -0.000 | 1 | 0.837 |
PKR |
0.838 | 0.217 | 1 | 0.880 |
HIPK4 |
0.838 | 0.078 | 1 | 0.841 |
PKACG |
0.838 | 0.082 | -2 | 0.793 |
IRE2 |
0.838 | 0.170 | 2 | 0.779 |
AMPKA1 |
0.838 | 0.051 | -3 | 0.823 |
TGFBR2 |
0.837 | -0.001 | -2 | 0.732 |
MARK4 |
0.837 | 0.027 | 4 | 0.679 |
NEK9 |
0.837 | 0.055 | 2 | 0.835 |
IKKE |
0.837 | -0.082 | 1 | 0.739 |
CHAK1 |
0.836 | 0.152 | 2 | 0.762 |
MLK4 |
0.836 | 0.164 | 2 | 0.757 |
DLK |
0.836 | -0.011 | 1 | 0.849 |
DYRK2 |
0.836 | 0.107 | 1 | 0.738 |
PDHK1 |
0.836 | -0.189 | 1 | 0.864 |
PKCZ |
0.836 | 0.166 | 2 | 0.804 |
ATM |
0.835 | 0.091 | 1 | 0.843 |
PAK3 |
0.835 | 0.084 | -2 | 0.850 |
AKT2 |
0.835 | 0.149 | -3 | 0.669 |
HUNK |
0.835 | -0.047 | 2 | 0.846 |
ULK1 |
0.835 | -0.076 | -3 | 0.765 |
MLK2 |
0.835 | 0.058 | 2 | 0.810 |
PRKD3 |
0.835 | 0.102 | -3 | 0.717 |
CAMK2D |
0.835 | -0.011 | -3 | 0.807 |
WNK3 |
0.834 | -0.074 | 1 | 0.837 |
CAMK2A |
0.834 | 0.056 | 2 | 0.811 |
PKG2 |
0.833 | 0.141 | -2 | 0.742 |
CDK5 |
0.833 | 0.140 | 1 | 0.685 |
CAMK4 |
0.833 | 0.014 | -3 | 0.786 |
CAMK2B |
0.832 | 0.033 | 2 | 0.787 |
MSK2 |
0.832 | 0.049 | -3 | 0.710 |
AMPKA2 |
0.832 | 0.044 | -3 | 0.791 |
NIM1 |
0.832 | 0.012 | 3 | 0.776 |
MYLK4 |
0.832 | 0.104 | -2 | 0.835 |
RSK4 |
0.831 | 0.080 | -3 | 0.719 |
PKACB |
0.831 | 0.126 | -2 | 0.746 |
PKCE |
0.831 | 0.256 | 2 | 0.776 |
CDK1 |
0.831 | 0.114 | 1 | 0.625 |
FAM20C |
0.831 | 0.066 | 2 | 0.629 |
TTBK2 |
0.831 | -0.065 | 2 | 0.742 |
MELK |
0.830 | 0.064 | -3 | 0.774 |
PRKX |
0.830 | 0.141 | -3 | 0.660 |
ANKRD3 |
0.830 | -0.030 | 1 | 0.865 |
NEK2 |
0.830 | 0.101 | 2 | 0.818 |
AURB |
0.830 | 0.124 | -2 | 0.725 |
QIK |
0.829 | 0.026 | -3 | 0.795 |
IKKA |
0.829 | -0.054 | -2 | 0.727 |
CDK8 |
0.829 | 0.036 | 1 | 0.675 |
GRK4 |
0.829 | -0.093 | -2 | 0.780 |
SMG1 |
0.829 | 0.122 | 1 | 0.856 |
YSK4 |
0.828 | 0.041 | 1 | 0.783 |
MSK1 |
0.828 | 0.082 | -3 | 0.718 |
AKT1 |
0.828 | 0.167 | -3 | 0.685 |
BMPR1B |
0.828 | 0.068 | 1 | 0.767 |
AURA |
0.828 | 0.118 | -2 | 0.694 |
PHKG1 |
0.828 | 0.076 | -3 | 0.795 |
SGK3 |
0.828 | 0.108 | -3 | 0.732 |
PKCT |
0.827 | 0.177 | 2 | 0.766 |
QSK |
0.827 | 0.048 | 4 | 0.660 |
BCKDK |
0.827 | -0.147 | -1 | 0.807 |
CDK2 |
0.827 | 0.106 | 1 | 0.709 |
PAK2 |
0.827 | 0.052 | -2 | 0.831 |
RIPK1 |
0.826 | -0.103 | 1 | 0.846 |
MST3 |
0.826 | 0.225 | 2 | 0.842 |
GRK7 |
0.826 | 0.034 | 1 | 0.762 |
PIM2 |
0.826 | 0.086 | -3 | 0.722 |
SIK |
0.826 | 0.051 | -3 | 0.729 |
KIS |
0.826 | 0.011 | 1 | 0.703 |
PRP4 |
0.825 | 0.135 | -3 | 0.786 |
LATS1 |
0.825 | 0.010 | -3 | 0.820 |
LATS2 |
0.825 | -0.065 | -5 | 0.690 |
DNAPK |
0.824 | 0.096 | 1 | 0.772 |
JNK3 |
0.824 | 0.074 | 1 | 0.648 |
JNK2 |
0.824 | 0.091 | 1 | 0.609 |
MASTL |
0.824 | -0.254 | -2 | 0.806 |
HIPK1 |
0.824 | 0.108 | 1 | 0.751 |
CAMK1G |
0.824 | 0.052 | -3 | 0.732 |
VRK2 |
0.823 | -0.048 | 1 | 0.904 |
CDK13 |
0.823 | 0.044 | 1 | 0.643 |
MARK3 |
0.823 | 0.046 | 4 | 0.633 |
P38A |
0.823 | 0.081 | 1 | 0.690 |
SSTK |
0.823 | 0.124 | 4 | 0.642 |
PHKG2 |
0.823 | 0.127 | -3 | 0.774 |
ALK4 |
0.823 | -0.053 | -2 | 0.763 |
PKCI |
0.823 | 0.180 | 2 | 0.783 |
HIPK2 |
0.823 | 0.106 | 1 | 0.642 |
MEK1 |
0.823 | -0.088 | 2 | 0.835 |
PLK1 |
0.823 | -0.081 | -2 | 0.760 |
HRI |
0.823 | 0.035 | -2 | 0.815 |
IRAK4 |
0.822 | 0.140 | 1 | 0.850 |
CDK19 |
0.822 | 0.037 | 1 | 0.634 |
NUAK1 |
0.822 | 0.003 | -3 | 0.759 |
WNK4 |
0.822 | 0.064 | -2 | 0.874 |
CDK3 |
0.822 | 0.143 | 1 | 0.562 |
EEF2K |
0.822 | 0.259 | 3 | 0.906 |
ZAK |
0.822 | 0.086 | 1 | 0.828 |
SMMLCK |
0.821 | 0.096 | -3 | 0.787 |
CDK18 |
0.821 | 0.072 | 1 | 0.598 |
CHK1 |
0.821 | 0.004 | -3 | 0.795 |
MEKK2 |
0.820 | 0.111 | 2 | 0.806 |
TAO3 |
0.820 | 0.133 | 1 | 0.804 |
DYRK3 |
0.820 | 0.117 | 1 | 0.770 |
DRAK1 |
0.820 | 0.009 | 1 | 0.707 |
PINK1 |
0.820 | 0.011 | 1 | 0.841 |
PKACA |
0.819 | 0.111 | -2 | 0.702 |
GSK3B |
0.819 | 0.043 | 4 | 0.473 |
TGFBR1 |
0.819 | -0.050 | -2 | 0.728 |
MEKK3 |
0.819 | -0.018 | 1 | 0.812 |
P38B |
0.819 | 0.069 | 1 | 0.623 |
MAPKAPK5 |
0.819 | -0.030 | -3 | 0.675 |
BRSK1 |
0.819 | -0.003 | -3 | 0.760 |
PERK |
0.818 | -0.007 | -2 | 0.780 |
CDK10 |
0.818 | 0.142 | 1 | 0.624 |
GSK3A |
0.818 | 0.069 | 4 | 0.485 |
DCAMKL1 |
0.818 | 0.046 | -3 | 0.760 |
PLK3 |
0.818 | -0.063 | 2 | 0.797 |
SNRK |
0.818 | -0.061 | 2 | 0.699 |
ERK1 |
0.817 | 0.061 | 1 | 0.608 |
CDK7 |
0.817 | 0.004 | 1 | 0.668 |
ALK2 |
0.817 | -0.022 | -2 | 0.734 |
DYRK4 |
0.817 | 0.087 | 1 | 0.644 |
P38G |
0.817 | 0.064 | 1 | 0.540 |
CDK12 |
0.817 | 0.045 | 1 | 0.617 |
MARK2 |
0.817 | -0.006 | 4 | 0.574 |
TAO2 |
0.817 | 0.164 | 2 | 0.854 |
HIPK3 |
0.816 | 0.089 | 1 | 0.733 |
MEK5 |
0.816 | -0.039 | 2 | 0.818 |
ACVR2A |
0.816 | -0.043 | -2 | 0.727 |
BRAF |
0.816 | -0.022 | -4 | 0.820 |
DYRK1A |
0.816 | 0.058 | 1 | 0.749 |
MEKK1 |
0.816 | 0.001 | 1 | 0.847 |
ERK2 |
0.816 | 0.036 | 1 | 0.665 |
TNIK |
0.815 | 0.262 | 3 | 0.916 |
BRSK2 |
0.815 | -0.037 | -3 | 0.782 |
CDK14 |
0.815 | 0.090 | 1 | 0.641 |
ERK7 |
0.815 | 0.139 | 2 | 0.616 |
MARK1 |
0.815 | -0.009 | 4 | 0.646 |
ACVR2B |
0.815 | -0.046 | -2 | 0.743 |
CDK16 |
0.815 | 0.119 | 1 | 0.565 |
PAK5 |
0.815 | 0.100 | -2 | 0.729 |
BUB1 |
0.814 | 0.213 | -5 | 0.772 |
NEK5 |
0.813 | 0.038 | 1 | 0.846 |
CDK9 |
0.813 | 0.016 | 1 | 0.650 |
AKT3 |
0.813 | 0.132 | -3 | 0.608 |
TLK2 |
0.813 | -0.089 | 1 | 0.847 |
NEK8 |
0.813 | 0.068 | 2 | 0.833 |
MPSK1 |
0.812 | 0.077 | 1 | 0.784 |
DCAMKL2 |
0.812 | 0.011 | -3 | 0.784 |
PKN1 |
0.812 | 0.110 | -3 | 0.695 |
CDK17 |
0.812 | 0.041 | 1 | 0.546 |
HGK |
0.812 | 0.199 | 3 | 0.907 |
CAMKK1 |
0.811 | 0.003 | -2 | 0.750 |
PAK4 |
0.811 | 0.097 | -2 | 0.729 |
CAMK1D |
0.811 | 0.044 | -3 | 0.658 |
DYRK1B |
0.810 | 0.060 | 1 | 0.661 |
CK1E |
0.810 | -0.018 | -3 | 0.527 |
CDK6 |
0.810 | 0.130 | 1 | 0.617 |
GRK2 |
0.810 | -0.094 | -2 | 0.678 |
MRCKB |
0.809 | 0.133 | -3 | 0.712 |
PASK |
0.809 | -0.015 | -3 | 0.821 |
TLK1 |
0.809 | -0.082 | -2 | 0.782 |
P70S6K |
0.808 | -0.006 | -3 | 0.675 |
PLK4 |
0.808 | -0.115 | 2 | 0.679 |
DAPK3 |
0.808 | 0.090 | -3 | 0.774 |
TTBK1 |
0.808 | -0.083 | 2 | 0.674 |
P38D |
0.808 | 0.066 | 1 | 0.570 |
BMPR1A |
0.807 | 0.011 | 1 | 0.757 |
MINK |
0.807 | 0.156 | 1 | 0.800 |
GAK |
0.807 | 0.022 | 1 | 0.808 |
LRRK2 |
0.806 | 0.087 | 2 | 0.857 |
CHK2 |
0.806 | 0.071 | -3 | 0.616 |
GCK |
0.806 | 0.102 | 1 | 0.781 |
CDK4 |
0.806 | 0.098 | 1 | 0.610 |
SGK1 |
0.805 | 0.083 | -3 | 0.589 |
VRK1 |
0.804 | 0.074 | 2 | 0.860 |
ROCK2 |
0.804 | 0.130 | -3 | 0.757 |
LOK |
0.804 | 0.108 | -2 | 0.790 |
IRAK1 |
0.804 | -0.088 | -1 | 0.776 |
NEK11 |
0.804 | -0.042 | 1 | 0.792 |
CAMK1A |
0.804 | 0.067 | -3 | 0.635 |
CAMKK2 |
0.804 | -0.049 | -2 | 0.753 |
TAK1 |
0.803 | 0.085 | 1 | 0.823 |
MRCKA |
0.803 | 0.090 | -3 | 0.724 |
MEKK6 |
0.803 | 0.087 | 1 | 0.818 |
PDK1 |
0.803 | -0.034 | 1 | 0.785 |
DAPK1 |
0.803 | 0.072 | -3 | 0.756 |
MAP3K15 |
0.803 | 0.067 | 1 | 0.797 |
HPK1 |
0.802 | 0.107 | 1 | 0.771 |
KHS1 |
0.802 | 0.166 | 1 | 0.787 |
MST2 |
0.802 | 0.004 | 1 | 0.808 |
KHS2 |
0.802 | 0.181 | 1 | 0.790 |
NEK4 |
0.801 | 0.007 | 1 | 0.817 |
MAK |
0.801 | 0.119 | -2 | 0.784 |
STK33 |
0.801 | -0.020 | 2 | 0.664 |
YSK1 |
0.801 | 0.150 | 2 | 0.804 |
HASPIN |
0.801 | 0.154 | -1 | 0.715 |
MOK |
0.800 | 0.118 | 1 | 0.766 |
DMPK1 |
0.800 | 0.145 | -3 | 0.741 |
LKB1 |
0.800 | -0.039 | -3 | 0.786 |
CK1A2 |
0.800 | -0.024 | -3 | 0.476 |
MST1 |
0.799 | 0.041 | 1 | 0.800 |
CK1D |
0.799 | -0.038 | -3 | 0.478 |
JNK1 |
0.799 | 0.030 | 1 | 0.594 |
NEK1 |
0.798 | 0.052 | 1 | 0.827 |
SLK |
0.797 | 0.022 | -2 | 0.726 |
MYO3B |
0.797 | 0.241 | 2 | 0.816 |
CK1G1 |
0.797 | -0.050 | -3 | 0.521 |
SBK |
0.797 | 0.048 | -3 | 0.558 |
GRK3 |
0.796 | -0.086 | -2 | 0.628 |
ROCK1 |
0.796 | 0.131 | -3 | 0.723 |
CK2A2 |
0.796 | 0.003 | 1 | 0.648 |
PLK2 |
0.794 | -0.025 | -3 | 0.768 |
OSR1 |
0.793 | 0.111 | 2 | 0.784 |
MYO3A |
0.792 | 0.197 | 1 | 0.827 |
RIPK2 |
0.790 | -0.129 | 1 | 0.763 |
PKG1 |
0.788 | 0.063 | -2 | 0.666 |
CK2A1 |
0.788 | -0.004 | 1 | 0.624 |
TTK |
0.788 | 0.074 | -2 | 0.765 |
TAO1 |
0.787 | 0.109 | 1 | 0.751 |
MEK2 |
0.784 | -0.164 | 2 | 0.796 |
ASK1 |
0.783 | 0.033 | 1 | 0.790 |
PBK |
0.782 | -0.045 | 1 | 0.718 |
PDHK3_TYR |
0.780 | 0.086 | 4 | 0.765 |
CRIK |
0.778 | 0.023 | -3 | 0.684 |
BIKE |
0.778 | 0.003 | 1 | 0.675 |
NEK3 |
0.777 | -0.083 | 1 | 0.791 |
ALPHAK3 |
0.776 | -0.018 | -1 | 0.784 |
TESK1_TYR |
0.776 | 0.061 | 3 | 0.893 |
YANK3 |
0.775 | -0.050 | 2 | 0.447 |
LIMK2_TYR |
0.773 | 0.110 | -3 | 0.858 |
PINK1_TYR |
0.772 | 0.015 | 1 | 0.844 |
EPHA6 |
0.770 | 0.113 | -1 | 0.861 |
PDHK4_TYR |
0.769 | -0.049 | 2 | 0.851 |
BMPR2_TYR |
0.769 | -0.024 | -1 | 0.852 |
PKMYT1_TYR |
0.769 | -0.057 | 3 | 0.845 |
MAP2K7_TYR |
0.768 | -0.162 | 2 | 0.852 |
MAP2K6_TYR |
0.768 | -0.092 | -1 | 0.874 |
RET |
0.768 | 0.032 | 1 | 0.840 |
MAP2K4_TYR |
0.767 | -0.154 | -1 | 0.874 |
LIMK1_TYR |
0.765 | -0.021 | 2 | 0.846 |
PDHK1_TYR |
0.765 | -0.081 | -1 | 0.882 |
EPHB4 |
0.765 | 0.062 | -1 | 0.863 |
STLK3 |
0.764 | -0.098 | 1 | 0.789 |
WEE1_TYR |
0.764 | 0.143 | -1 | 0.792 |
ABL2 |
0.763 | 0.084 | -1 | 0.850 |
TNNI3K_TYR |
0.763 | 0.163 | 1 | 0.878 |
TYK2 |
0.763 | -0.033 | 1 | 0.838 |
TYRO3 |
0.762 | 0.022 | 3 | 0.796 |
MST1R |
0.762 | -0.039 | 3 | 0.785 |
CSF1R |
0.761 | 0.010 | 3 | 0.761 |
ROS1 |
0.761 | 0.015 | 3 | 0.758 |
AAK1 |
0.760 | 0.019 | 1 | 0.563 |
JAK2 |
0.759 | -0.054 | 1 | 0.836 |
CK1A |
0.759 | -0.073 | -3 | 0.390 |
ABL1 |
0.758 | 0.042 | -1 | 0.840 |
ITK |
0.758 | 0.080 | -1 | 0.829 |
TXK |
0.757 | 0.088 | 1 | 0.792 |
FLT3 |
0.757 | 0.008 | 3 | 0.790 |
DDR1 |
0.757 | -0.100 | 4 | 0.674 |
PDGFRB |
0.756 | -0.022 | 3 | 0.789 |
JAK3 |
0.754 | -0.059 | 1 | 0.812 |
EPHA4 |
0.753 | -0.026 | 2 | 0.796 |
YES1 |
0.753 | -0.024 | -1 | 0.844 |
TNK1 |
0.753 | 0.016 | 3 | 0.769 |
TEC |
0.752 | 0.070 | -1 | 0.794 |
EPHB1 |
0.752 | -0.020 | 1 | 0.846 |
FER |
0.752 | -0.083 | 1 | 0.853 |
KDR |
0.752 | -0.019 | 3 | 0.716 |
BTK |
0.752 | 0.029 | -1 | 0.818 |
KIT |
0.752 | -0.054 | 3 | 0.760 |
FGR |
0.752 | -0.083 | 1 | 0.817 |
TNK2 |
0.752 | -0.021 | 3 | 0.696 |
LCK |
0.751 | 0.056 | -1 | 0.831 |
BMX |
0.751 | 0.048 | -1 | 0.778 |
EPHB3 |
0.750 | -0.022 | -1 | 0.853 |
HCK |
0.750 | -0.014 | -1 | 0.835 |
SRMS |
0.750 | -0.045 | 1 | 0.838 |
EPHB2 |
0.750 | -0.008 | -1 | 0.845 |
PDGFRA |
0.749 | -0.074 | 3 | 0.794 |
JAK1 |
0.749 | -0.008 | 1 | 0.776 |
BLK |
0.748 | 0.054 | -1 | 0.832 |
FGFR2 |
0.748 | -0.126 | 3 | 0.745 |
INSRR |
0.747 | -0.121 | 3 | 0.708 |
FRK |
0.747 | 0.028 | -1 | 0.868 |
NEK10_TYR |
0.746 | -0.075 | 1 | 0.685 |
TEK |
0.746 | -0.089 | 3 | 0.701 |
AXL |
0.746 | -0.073 | 3 | 0.723 |
LTK |
0.745 | -0.044 | 3 | 0.706 |
CK1G3 |
0.745 | -0.065 | -3 | 0.345 |
MERTK |
0.745 | -0.036 | 3 | 0.726 |
PTK6 |
0.745 | -0.099 | -1 | 0.777 |
MET |
0.744 | -0.082 | 3 | 0.744 |
EPHA7 |
0.744 | -0.019 | 2 | 0.802 |
FLT1 |
0.744 | -0.066 | -1 | 0.833 |
ALK |
0.743 | -0.072 | 3 | 0.689 |
FGFR1 |
0.742 | -0.158 | 3 | 0.722 |
YANK2 |
0.741 | -0.077 | 2 | 0.466 |
EPHA1 |
0.741 | -0.020 | 3 | 0.715 |
EPHA3 |
0.741 | -0.093 | 2 | 0.771 |
FLT4 |
0.739 | -0.119 | 3 | 0.706 |
FYN |
0.739 | -0.020 | -1 | 0.793 |
DDR2 |
0.738 | -0.024 | 3 | 0.683 |
MATK |
0.738 | -0.059 | -1 | 0.779 |
LYN |
0.738 | -0.031 | 3 | 0.697 |
ERBB2 |
0.737 | -0.140 | 1 | 0.784 |
CSK |
0.736 | -0.076 | 2 | 0.800 |
NTRK1 |
0.735 | -0.207 | -1 | 0.844 |
EPHA5 |
0.734 | -0.059 | 2 | 0.784 |
FGFR3 |
0.734 | -0.165 | 3 | 0.710 |
PTK2B |
0.734 | -0.059 | -1 | 0.813 |
NTRK2 |
0.733 | -0.177 | 3 | 0.713 |
MUSK |
0.733 | -0.034 | 1 | 0.676 |
EGFR |
0.733 | -0.069 | 1 | 0.702 |
EPHA8 |
0.732 | -0.064 | -1 | 0.822 |
INSR |
0.732 | -0.161 | 3 | 0.688 |
NTRK3 |
0.728 | -0.160 | -1 | 0.807 |
SRC |
0.727 | -0.091 | -1 | 0.797 |
SYK |
0.725 | -0.051 | -1 | 0.763 |
FGFR4 |
0.724 | -0.117 | -1 | 0.795 |
PTK2 |
0.722 | -0.068 | -1 | 0.743 |
CK1G2 |
0.720 | -0.098 | -3 | 0.438 |
EPHA2 |
0.719 | -0.097 | -1 | 0.796 |
ERBB4 |
0.715 | -0.088 | 1 | 0.709 |
IGF1R |
0.714 | -0.183 | 3 | 0.625 |
FES |
0.701 | -0.160 | -1 | 0.746 |
ZAP70 |
0.698 | -0.083 | -1 | 0.700 |