Motif 703 (n=296)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NMY6 | ANXA2P2 | S112 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| A6QL63 | ABTB3 | S65 | ochoa | Ankyrin repeat- and BTB/POZ domain-containing protein 3 (BTB/POZ domain-containing protein 11) | None |
| B9A064 | IGLL5 | S192 | ochoa | Immunoglobulin lambda-like polypeptide 5 (G lambda-1) (Germline immunoglobulin lambda 1) | None |
| O14640 | DVL1 | S676 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O14641 | DVL2 | S717 | ochoa | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14976 | GAK | S21 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15067 | PFAS | S569 | ochoa | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| O15417 | TNRC18 | S1878 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43156 | TTI1 | S106 | ochoa | TELO2-interacting protein 1 homolog (Protein SMG10) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650, ECO:0000269|PubMed:36724785}. |
| O43175 | PHGDH | S55 | ochoa|psp | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| O43299 | AP5Z1 | S732 | ochoa | AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) | As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20613862, ECO:0000269|PubMed:22022230}. |
| O43432 | EIF4G3 | S1412 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43639 | NCK2 | S176 | ochoa | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}. |
| O43752 | STX6 | S133 | ochoa | Syntaxin-6 | SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. {ECO:0000250|UniProtKB:Q63635}. |
| O43852 | CALU | S44 | ochoa | Calumenin (Crocalbin) (IEF SSP 9302) | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}. |
| O43896 | KIF1C | S674 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| O60287 | URB1 | S1097 | ochoa | Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog) | None |
| O60684 | KPNA6 | S459 | ochoa | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
| O75128 | COBL | S61 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75167 | PHACTR2 | S424 | ochoa | Phosphatase and actin regulator 2 | None |
| O75665 | OFD1 | S826 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75694 | NUP155 | S1133 | ochoa | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}. |
| O75764 | TCEA3 | S81 | ochoa | Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| O76003 | GLRX3 | S118 | ochoa | Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) | Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250|UniProtKB:Q9CQM9, ECO:0000269|PubMed:23615448, ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}. |
| O94875 | SORBS2 | S843 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O95071 | UBR5 | S327 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95196 | CSPG5 | S28 | ochoa | Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C) | May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. {ECO:0000269|PubMed:15358134}. |
| O95210 | STBD1 | S188 | ochoa | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95425 | SVIL | S134 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95466 | FMNL1 | S914 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O95714 | HERC2 | S1938 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| O96017 | CHEK2 | S518 | ochoa | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P01303 | NPY | S68 | ochoa | Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)] | NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. |
| P02545 | LMNA | S71 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P05408 | SCG5 | S141 | ochoa | Neuroendocrine protein 7B2 (Pituitary polypeptide) (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide] | Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. {ECO:0000269|PubMed:7913882}. |
| P05814 | CSN2 | S24 | psp | Beta-casein | Important role in determination of the surface properties of the casein micelles. |
| P07203 | GPX1 | S153 | ochoa | Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) (Phospholipid-hydroperoxide glutathione peroxidase GPX1) (EC 1.11.1.12) | Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:11115402). {ECO:0000269|PubMed:11115402, ECO:0000269|PubMed:36608588}. |
| P07355 | ANXA2 | S112 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07948 | LYN | S228 | ochoa | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P08195 | SLC3A2 | S607 | ochoa | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P0CF74 | IGLC6 | S84 | ochoa | Immunoglobulin lambda constant 6 (Ig lambda-6 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P0CG04 | IGLC1 | S84 | ochoa | Immunoglobulin lambda constant 1 (Ig lambda chain C region MGC) (Ig lambda-1 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P0DOY2 | IGLC2 | S84 | ochoa | Immunoglobulin lambda constant 2 (Ig lambda chain C region Kern) (Ig lambda chain C region NIG-64) (Ig lambda chain C region SH) (Ig lambda chain C region X) (Ig lambda-2 chain C region) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P0DOY3 | IGLC3 | S84 | ochoa | Immunoglobulin lambda constant 3 (Ig lambda chain C region DOT) (Ig lambda chain C region NEWM) (Ig lambda-3 chain C regions) | Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P10398 | ARAF | S580 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P10809 | HSPD1 | S499 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11137 | MAP2 | S1398 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11532 | DMD | S2437 | ochoa | Dystrophin | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}. |
| P12270 | TPR | S829 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12882 | MYH1 | S1702 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1698 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1700 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P15260 | IFNGR1 | S306 | ochoa | Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). {ECO:0000250|UniProtKB:P15261, ECO:0000269|PubMed:10986460, ECO:0000269|PubMed:20015550, ECO:0000269|PubMed:28883123, ECO:0000269|PubMed:2971451, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7617032, ECO:0000269|PubMed:7673114}. |
| P15924 | DSP | S1259 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16066 | NPR1 | S534 | psp | Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499). {ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:36016499, ECO:0000269|PubMed:39543315}. |
| P18583 | SON | S2181 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P20248 | CCNA2 | S154 | psp | Cyclin-A2 (Cyclin-A) (Cyclin A) | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}. |
| P25054 | APC | S245 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25705 | ATP5F1A | Y337 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P27815 | PDE4A | S157 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P27986 | PIK3R1 | S608 | ochoa|psp | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}. |
| P28562 | DUSP1 | S323 | psp | Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250|UniProtKB:P28563}. |
| P29401 | TKT | S348 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P31274 | HOXC9 | S159 | ochoa | Homeobox protein Hox-C9 (Homeobox protein Hox-3B) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P31645 | SLC6A4 | S149 | psp | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) | Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}. |
| P32241 | VIPR1 | S250 | psp | Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35477937, PubMed:36385145, PubMed:8179610). {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8179610}. |
| P35612 | ADD2 | S530 | ochoa | Beta-adducin (Erythrocyte adducin subunit beta) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}. |
| P35916 | FLT4 | S1217 | ochoa | Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| P38398 | BRCA1 | S1514 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P38936 | CDKN1A | S31 | ochoa | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P42166 | TMPO | S442 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P46100 | ATRX | S656 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P47710 | CSN1S1 | S31 | psp | Alpha-S1-casein [Cleaved into: Casoxin-D] | Important role in the capacity of milk to transport calcium phosphate.; FUNCTION: Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors. |
| P48681 | NES | S556 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S702 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S713 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S746 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S831 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P50395 | GDI2 | S382 | ochoa|psp | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P50993 | ATP1A2 | S464 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P52292 | KPNA2 | S24 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P52565 | ARHGDIA | S96 | psp | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
| P52948 | NUP98 | S746 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54105 | CLNS1A | S195 | ochoa | Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) | Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:10330151, PubMed:18984161). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161). {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713266, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. |
| P54792 | DVL1P1 | S651 | ochoa | Putative segment polarity protein dishevelled homolog DVL1P1 (DSH homolog 1-like) (Segment polarity protein dishevelled homolog DVL-1-like) (Dishevelled-1-like) | May play a role in the signal transduction pathway mediated by multiple Wnt genes. |
| P55957 | BID | S67 | ochoa|psp | BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] | Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622). {ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:32029622}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}. |
| P56962 | STX17 | S202 | psp | Syntaxin-17 | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502). STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502, PubMed:28504273). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). {ECO:0000269|PubMed:21545355, ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:28504273}. |
| P59923 | ZNF445 | S171 | ochoa | Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15) | Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). {ECO:0000269|PubMed:30602440}. |
| P61247 | RPS3A | S238 | ochoa | Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P78352 | DLG4 | S561 | psp | Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) | Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}. |
| P78367 | NKX3-2 | S73 | ochoa | Homeobox protein Nkx-3.2 (Bagpipe homeobox protein homolog 1) (Homeobox protein NK-3 homolog B) | Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). {ECO:0000250}. |
| Q00610 | CLTC | S1462 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q00978 | IRF9 | S253 | psp | Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) | Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000269|PubMed:30143481}. |
| Q01082 | SPTBN1 | S257 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01850 | CDR2 | S415 | ochoa | Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen) | None |
| Q03252 | LMNB2 | S134 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q07157 | TJP1 | S212 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07343 | PDE4B | S145 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978}. |
| Q12888 | TP53BP1 | S525 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13127 | REST | S861 | psp | RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:10449787, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185}. |
| Q13370 | PDE3B | S578 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q13416 | ORC2 | S282 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13495 | MAMLD1 | S218 | ochoa | Mastermind-like domain-containing protein 1 (F18) (Protein CG1) | Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}. |
| Q13557 | CAMK2D | S319 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13823 | GNL2 | S234 | ochoa | Nucleolar GTP-binding protein 2 (Autoantigen NGP-1) | GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). {ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}. |
| Q14149 | MORC3 | S765 | ochoa | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}. |
| Q14151 | SAFB2 | S282 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14244 | MAP7 | S209 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14289 | PTK2B | S778 | ochoa|psp | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14315 | FLNC | S2655 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14542 | SLC29A2 | S252 | ochoa | Equilibrative nucleoside transporter 2 (hENT2) (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2) | Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683, PubMed:9396714, PubMed:9478986). Functions as a Na(+)-independent, passive transporter (PubMed:9478986). Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683, PubMed:9396714, PubMed:9478986). Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:16214850, PubMed:21795683). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites (PubMed:12527552). Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (PubMed:23639800). Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (By similarity). {ECO:0000250|UniProtKB:O54699, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:12590919, ECO:0000269|PubMed:16214850, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:9396714, ECO:0000269|PubMed:9478986}.; FUNCTION: [Isoform 3]: Non functional nucleoside transporter protein for adenosine or thymidine transport. Does not express on cell membrane. {ECO:0000269|PubMed:12527552}. |
| Q14562 | DHX8 | S385 | ochoa | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. |
| Q14669 | TRIP12 | S515 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14676 | MDC1 | S760 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14690 | PDCD11 | S1360 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q14966 | ZNF638 | S1658 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15036 | SNX17 | S446 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15058 | KIF14 | S1044 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15075 | EEA1 | S359 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| Q15173 | PPP2R5B | S368 | psp | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta) | As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000269|PubMed:21329884}. |
| Q15233 | NONO | S149 | ochoa | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}. |
| Q15293 | RCN1 | S159 | ochoa | Reticulocalbin-1 | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. |
| Q15424 | SAFB | S283 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15643 | TRIP11 | S486 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q15742 | NAB2 | S479 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q15758 | SLC1A5 | S491 | ochoa | Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) | Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). {ECO:0000250|UniProtKB:D3ZJ25, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:17094966, ECO:0000269|PubMed:23492904, ECO:0000269|PubMed:23756778, ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:26492990, ECO:0000269|PubMed:29872227, ECO:0000269|PubMed:32733894, ECO:0000269|PubMed:34741534, ECO:0000269|PubMed:8702519}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. {ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. {ECO:0000269|PubMed:10196349}. |
| Q2KJY2 | KIF26B | S1500 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2TBE0 | CWF19L2 | S479 | ochoa | CWF19-like protein 2 | None |
| Q3KQU3 | MAP7D1 | S280 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q4G0F5 | VPS26B | S302 | ochoa | Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity). {ECO:0000250|UniProtKB:O75436, ECO:0000250|UniProtKB:Q8C0E2}. |
| Q52LA3 | LIN52 | S28 | ochoa|psp | Protein lin-52 homolog | None |
| Q5CZC0 | FSIP2 | S3181 | ochoa | Fibrous sheath-interacting protein 2 | Plays a role in spermatogenesis. {ECO:0000305|PubMed:30137358}. |
| Q5M775 | SPECC1 | S218 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5SXM2 | SNAPC4 | S1170 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5T011 | SZT2 | S2458 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T0Z8 | C6orf132 | S558 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5TGY3 | AHDC1 | S1324 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5U3C3 | TMEM164 | S71 | ochoa | Transmembrane protein 164 (Arachidonoyl ether phospholipid synthase) | Positive regulator of ferroptosis (PubMed:35947500, PubMed:36782012). Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20:4) of diacylglycerophospholipids, generating C20:4 ether glycerophospholipids (ePEs) such as 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine (PE (P-18:0/20:4)), which promotes ferroptosis (PubMed:36782012). Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death (PubMed:35947500). {ECO:0000269|PubMed:35947500, ECO:0000269|PubMed:36782012}. |
| Q5VT06 | CEP350 | S2295 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VWQ8 | DAB2IP | S747 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q63ZY3 | KANK2 | S428 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q658Y4 | FAM91A1 | S340 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q66GS9 | CEP135 | S439 | ochoa | Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) | Centrosomal microtubule-binding protein involved in centriole biogenesis (PubMed:27477386). Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962, ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27477386}. |
| Q66K74 | MAP1S | S731 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q6GPH4 | XAF1 | S253 | ochoa | XIAP-associated factor 1 (BIRC4-binding protein) | Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. {ECO:0000269|PubMed:11175744, ECO:0000269|PubMed:12029096, ECO:0000269|PubMed:16432762, ECO:0000269|PubMed:17329253, ECO:0000269|PubMed:17613533}. |
| Q6IQ26 | DENND5A | S52 | ochoa | DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) | Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}. |
| Q6P2H3 | CEP85 | S663 | ochoa | Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) | Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292}. |
| Q6P4F7 | ARHGAP11A | S340 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6P9A1 | ZNF530 | S130 | ochoa | Zinc finger protein 530 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6P9H4 | CNKSR3 | S244 | ochoa | Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) | Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC). {ECO:0000269|PubMed:22851176}. |
| Q6PCD5 | RFWD3 | S46 | psp | E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201) | E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:33321094). Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929). Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658). Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098). May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098). In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 (PubMed:20173098). Required to translesion DNA synthesis across DNA-protein cross-link adducts by catalyzing ubiquitination of proteins on single-stranded DNA (ssDNA) (PubMed:33321094). {ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:21558276, ECO:0000269|PubMed:26474068, ECO:0000269|PubMed:28575657, ECO:0000269|PubMed:28575658, ECO:0000269|PubMed:28691929, ECO:0000269|PubMed:33321094}. |
| Q6PJG6 | BRAT1 | S582 | ochoa | Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}. |
| Q6PKG0 | LARP1 | S700 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6PL18 | ATAD2 | S84 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6RI45 | BRWD3 | S693 | ochoa | Bromodomain and WD repeat-containing protein 3 | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}. |
| Q6VMQ6 | ATF7IP | S477 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6WCQ1 | MPRIP | S671 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZU80 | CEP128 | S961 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q6ZVD8 | PHLPP2 | S1189 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| Q7L9L4 | MOB1B | S38 | ochoa | MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}. |
| Q7Z3K6 | MIER3 | S122 | ochoa | Mesoderm induction early response protein 3 (Mi-er3) | Transcriptional repressor. {ECO:0000250}. |
| Q7Z6Z7 | HUWE1 | Y2744 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z6Z7 | HUWE1 | S2855 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86UT5 | NHERF4 | S436 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4) | Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}. |
| Q86UZ6 | ZBTB46 | S326 | ochoa | Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340) | Functions as a transcriptional repressor for PRDM1. {ECO:0000250}. |
| Q86X27 | RALGPS2 | S343 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q86XA9 | HEATR5A | S1704 | ochoa | HEAT repeat-containing protein 5A | None |
| Q86XK3 | SFR1 | S65 | ochoa | Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog) | Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23874500}. |
| Q8IUD2 | ERC1 | S252 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IVF2 | AHNAK2 | S5283 | ochoa | Protein AHNAK2 | None |
| Q8IWJ2 | GCC2 | S935 | ochoa | GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) | Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}. |
| Q8IWZ8 | SUGP1 | S411 | ochoa | SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) | Plays a role in pre-mRNA splicing. |
| Q8IYD8 | FANCM | S997 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8N3D4 | EHBP1L1 | S661 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N4Y2 | CRACR2B | S174 | ochoa | EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) | Plays a role in store-operated Ca(2+) entry (SOCE). {ECO:0000269|PubMed:20418871}. |
| Q8N5A5 | ZGPAT | S56 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8N5Y2 | MSL3 | S318 | ochoa | MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000250|UniProtKB:Q9WVG9, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:30224647, ECO:0000269|PubMed:33837287}. |
| Q8N8U9 | BMPER | S414 | ochoa | BMP-binding endothelial regulator protein (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2) | Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. {ECO:0000269|PubMed:14766204}. |
| Q8ND56 | LSM14A | S183 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NF91 | SYNE1 | S8386 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NFC6 | BOD1L1 | S2714 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFU5 | IPMK | S350 | ochoa | Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase) | Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:28882892, PubMed:30420721). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). {ECO:0000250|UniProtKB:Q7TT16, ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481, ECO:0000269|PubMed:28882892, ECO:0000269|PubMed:29883610, ECO:0000269|PubMed:30420721, ECO:0000269|PubMed:30624931}. |
| Q8NI35 | PATJ | S459 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8TCN5 | ZNF507 | S74 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TCU6 | PREX1 | S839 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TF72 | SHROOM3 | S1131 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8TF76 | HASPIN | S453 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WUM0 | NUP133 | S492 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WX93 | PALLD | S632 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WXE9 | STON2 | S326 | ochoa | Stonin-2 (Stoned B) | Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}. |
| Q8WXI2 | CNKSR2 | S248 | ochoa | Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) | May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}. |
| Q8WYA6 | CTNNBL1 | S389 | ochoa | Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (Testis development protein NYD-SP19) | Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies (PubMed:32484799). {ECO:0000269|PubMed:32484799}. |
| Q8WYP5 | AHCTF1 | S1513 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92529 | SHC3 | S479 | ochoa | SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) | Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. |
| Q92997 | DVL3 | S697 | ochoa|psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q969R8 | ITFG2 | S220 | ochoa | KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}. |
| Q969U6 | FBXW5 | S275 | ochoa | F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) | Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. {ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:19232515, ECO:0000269|PubMed:21725316}. |
| Q96AQ6 | PBXIP1 | S72 | ochoa | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96AY4 | TTC28 | S47 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96D09 | GPRASP2 | S512 | ochoa | G-protein coupled receptor-associated sorting protein 2 (GASP-2) | May play a role in regulation of a variety of G-protein coupled receptors. {ECO:0000269|PubMed:15086532}. |
| Q96DU7 | ITPKC | S322 | ochoa | Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:11085927, PubMed:12747803). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity). {ECO:0000250|UniProtKB:Q80ZG2, ECO:0000269|PubMed:11085927, ECO:0000269|PubMed:12747803}. |
| Q96EK5 | KIFBP | S178 | ochoa | KIF-binding protein (KIF1-binding protein) (Kinesin family binding protein) | Activator of KIF1B plus-end-directed microtubule motor activity (PubMed:16225668). Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. {ECO:0000269|PubMed:16225668, ECO:0000269|PubMed:20621975, ECO:0000269|PubMed:23427148}. |
| Q96FS4 | SIPA1 | S817 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96G74 | OTUD5 | S527 | ochoa | OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:33523931}. |
| Q96JE7 | SEC16B | S234 | ochoa | Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) | Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:21768384, PubMed:22355596). Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes (PubMed:21768384). {ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:21768384, ECO:0000303|PubMed:22355596}. |
| Q96KR1 | ZFR | S960 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96KS0 | EGLN2 | S234 | psp | Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) | Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}. |
| Q96M27 | PRRC1 | S254 | ochoa | Protein PRRC1 (Proline-rich and coiled-coil-containing protein 1) | May act as a regulator of the protein kinase A (PKA) activity during embryonic development. {ECO:0000250|UniProtKB:Q5XJA3}. |
| Q96PY6 | NEK1 | S837 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96Q42 | ALS2 | S1335 | ochoa | Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) | May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}. |
| Q96Q89 | KIF20B | S1740 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96R06 | SPAG5 | S159 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RU2 | USP28 | S1053 | ochoa | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
| Q96S38 | RPS6KC1 | S282 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q99567 | NUP88 | S517 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q99698 | LYST | S1516 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q9BPX5 | ARPC5L | S64 | ochoa | Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) | May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. |
| Q9BSW2 | CRACR2A | S263 | ochoa | EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46) (EC 3.6.5.2) | [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269|PubMed:20418871, ECO:0000269|PubMed:27016526}.; FUNCTION: [Isoform 2]: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (PubMed:31092558). During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function (PubMed:31092558). Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (PubMed:30814157). Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526). In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (PubMed:27016526). Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160). Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (PubMed:27016526). {ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:29987160, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. |
| Q9BUA3 | SPINDOC | S121 | ochoa | Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC) | Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000269|PubMed:33574238, ECO:0000269|PubMed:34737271}. |
| Q9BVV6 | KIAA0586 | S713 | ochoa | Protein TALPID3 | Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9, ECO:0000269|PubMed:24421332}. |
| Q9BX63 | BRIP1 | S1109 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BXW6 | OSBPL1A | S460 | ochoa | Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) | Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000250, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17428193}. |
| Q9BY89 | KIAA1671 | S402 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYB0 | SHANK3 | S1529 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZQ8 | NIBAN1 | S719 | ochoa | Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) | Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}. |
| Q9C0K0 | BCL11B | S678 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H0J9 | PARP12 | S633 | ochoa | Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4 (PubMed:39888989). Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1 (PubMed:34969853). Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation (PubMed:39465252). {ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:34187568, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:39465252, ECO:0000269|PubMed:39888989}. |
| Q9H2B2 | SYT4 | S135 | psp | Synaptotagmin-4 (Synaptotagmin IV) (SytIV) | Synaptotagmin family member which does not bind Ca(2+) (By similarity) (PubMed:23999003). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P50232, ECO:0000269|PubMed:23999003}. |
| Q9H501 | ESF1 | S198 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H582 | ZNF644 | S1074 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H788 | SH2D4A | S315 | ochoa | SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}. |
| Q9H7U1 | CCSER2 | S705 | ochoa | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}. |
| Q9H8M7 | MINDY3 | S121 | ochoa | Ubiquitin carboxyl-terminal hydrolase MINDY-3 (EC 3.4.19.12) (Dermal papilla-derived protein 5) (Deubiquitinating enzyme MINDY-3) (Protein CARP) | Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000269|PubMed:27292798}. |
| Q9H8S9 | MOB1A | S38 | ochoa | MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}. |
| Q9HAZ2 | PRDM16 | S1054 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9HC77 | CPAP | S589 | psp | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9HCD6 | TANC2 | S235 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCK8 | CHD8 | S440 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9HDC5 | JPH1 | S590 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NQW6 | ANLN | S536 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NRA8 | EIF4ENIF1 | S426 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRC1 | ST7 | S386 | ochoa | Suppressor of tumorigenicity 7 protein (Protein FAM4A1) (Protein HELG) | May act as a tumor suppressor. {ECO:0000269|PubMed:16474848}. |
| Q9NUE0 | ZDHHC18 | S171 | ochoa | Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:27481942, ECO:0000269|PubMed:35438208}. |
| Q9NXL9 | MCM9 | S976 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9NY61 | AATF | S316 | ochoa | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9NY61 | AATF | S391 | ochoa | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9NYB0 | TERF2IP | S111 | ochoa | Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}. |
| Q9NZC9 | SMARCAL1 | S129 | ochoa|psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9P107 | GMIP | S480 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9P219 | CCDC88C | S446 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P243 | ZFAT | S643 | ochoa | Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) | May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}. |
| Q9P270 | SLAIN2 | S247 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9UHY1 | NRBP1 | S363 | ochoa | Nuclear receptor-binding protein | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}. |
| Q9UK41 | VPS28 | S62 | ochoa | Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. {ECO:0000269|PubMed:11916981}. |
| Q9UKK3 | PARP4 | S1511 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UKX2 | MYH2 | S1704 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULI3 | HEG1 | S1293 | ochoa | Protein HEG homolog 1 | Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}. |
| Q9ULT0 | TTC7A | S674 | ochoa | Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. |
| Q9UNY4 | TTF2 | S271 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPA5 | BSN | S2849 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9UQE7 | SMC3 | S1065 | ochoa|psp | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
| Q9Y289 | SLC5A6 | S585 | ochoa | Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6) | Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:10329687, PubMed:15561972, PubMed:19211916, PubMed:20980265, PubMed:21570947, PubMed:22015582, PubMed:25809983, PubMed:25971966, PubMed:27904971, PubMed:28052864, PubMed:31754459). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (PubMed:10329687, PubMed:20980265). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:19211916). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983). {ECO:0000250|UniProtKB:Q5U4D8, ECO:0000269|PubMed:10329687, ECO:0000269|PubMed:15561972, ECO:0000269|PubMed:19211916, ECO:0000269|PubMed:20980265, ECO:0000269|PubMed:21570947, ECO:0000269|PubMed:22015582, ECO:0000269|PubMed:25809983, ECO:0000269|PubMed:25971966, ECO:0000269|PubMed:27904971, ECO:0000269|PubMed:28052864, ECO:0000269|PubMed:31754459}. |
| Q9Y2I6 | NINL | S185 | psp | Ninein-like protein | Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}. |
| Q9Y2X9 | ZNF281 | S401 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y2X9 | ZNF281 | S785 | ochoa|psp | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y3L3 | SH3BP1 | S262 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y4G6 | TLN2 | S1032 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y6K9 | IKBKG | S43 | psp | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
| Q13242 | SRSF9 | S172 | Sugiyama | Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9) | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}. |
| P12004 | PCNA | S161 | Sugiyama | Proliferating cell nuclear antigen (PCNA) (Cyclin) | Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (PubMed:35585232). Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737). {ECO:0000269|PubMed:18719106, ECO:0000269|PubMed:19443450, ECO:0000269|PubMed:24695737, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:38459011}. |
| O15146 | MUSK | Y570 | Sugiyama | Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) | Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:25537362}. |
| P17174 | GOT1 | S85 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
| Q86TB9 | PATL1 | S564 | Sugiyama | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}. |
| Q9UQ80 | PA2G4 | S335 | Sugiyama | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| P21333 | FLNA | S732 | Sugiyama | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| Q8TEW0 | PARD3 | S728 | Sugiyama | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| P08631 | HCK | S130 | Sugiyama | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
| P09769 | FGR | S130 | Sugiyama | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| Q13011 | ECH1 | S43 | Sugiyama | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-) | Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. {ECO:0000250|UniProtKB:Q62651}. |
| Q13362 | PPP2R5C | S337 | SIGNOR | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. {ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}. |
| Q08378 | GOLGA3 | S497 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| P57081 | WDR4 | S128 | Sugiyama | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (Protein Wuho homolog) (hWH) (WD repeat-containing protein 4) | Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031083, PubMed:31031084, PubMed:36599982, PubMed:36599985, PubMed:37369656). In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding (PubMed:36599982, PubMed:36599985, PubMed:37369656). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:12403464, PubMed:34352206, PubMed:34352207, PubMed:36599982, PubMed:36599985, PubMed:37369656). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (PubMed:36599982, PubMed:36599985). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084, PubMed:37379838). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069). {ECO:0000269|PubMed:12403464, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:31031083, ECO:0000269|PubMed:31031084, ECO:0000269|PubMed:34352206, ECO:0000269|PubMed:34352207, ECO:0000269|PubMed:36599982, ECO:0000269|PubMed:36599985, ECO:0000269|PubMed:37369656, ECO:0000269|PubMed:37379838}. |
| Q9UK32 | RPS6KA6 | S438 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q07666 | KHDRBS1 | S117 | Sugiyama | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q13554 | CAMK2B | S26 | Sugiyama | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q9UH03 | SEPTIN3 | S91 | SIGNOR|iPTMNet|EPSD | Neuronal-specific septin-3 | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). {ECO:0000250, ECO:0000305}. |
| Q5S007 | LRRK2 | S1445 | EPSD|PSP|Sugiyama | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q6XUX3 | DSTYK | S603 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| Q8NEY8 | PPHLN1 | S329 | Sugiyama | Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}. |
| P62714 | PPP2CB | S75 | Sugiyama | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}. |
| P67775 | PPP2CA | S75 | Sugiyama | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}. |
| Q9BSV6 | TSEN34 | S93 | Sugiyama | tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) | Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q9BYT3 | STK33 | S326 | Sugiyama | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| P49005 | POLD2 | S75 | Sugiyama | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:12403614, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906}. |
| Q15643 | TRIP11 | S1376 | Sugiyama | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q8IZ83 | ALDH16A1 | S427 | Sugiyama | Aldehyde dehydrogenase family 16 member A1 | None |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 2.333505e-08 | 7.632 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 5.677399e-07 | 6.246 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.346241e-06 | 5.871 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 4.209517e-06 | 5.376 |
| R-HSA-4839744 | Signaling by APC mutants | 1.260733e-05 | 4.899 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.260733e-05 | 4.899 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.260733e-05 | 4.899 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.260733e-05 | 4.899 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.750489e-05 | 4.757 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.376985e-05 | 4.624 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.376985e-05 | 4.624 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.376985e-05 | 4.624 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.376985e-05 | 4.624 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.376985e-05 | 4.624 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.203133e-05 | 4.920 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.432286e-05 | 4.844 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.432286e-05 | 4.844 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.999489e-05 | 4.699 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.999489e-05 | 4.699 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.345926e-05 | 4.630 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.750489e-05 | 4.757 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.750489e-05 | 4.757 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.594285e-05 | 4.797 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.345926e-05 | 4.630 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 6.429229e-06 | 5.192 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.772552e-05 | 4.751 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.467787e-05 | 4.608 |
| R-HSA-5673000 | RAF activation | 2.740381e-05 | 4.562 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.740381e-05 | 4.562 |
| R-HSA-68875 | Mitotic Prophase | 2.836617e-05 | 4.547 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.187869e-05 | 4.496 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.263767e-05 | 4.370 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.903995e-05 | 4.309 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 5.338081e-05 | 4.273 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.620915e-05 | 4.250 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 6.421390e-05 | 4.192 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 6.421390e-05 | 4.192 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 6.421390e-05 | 4.192 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.849726e-05 | 4.164 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 7.312680e-05 | 4.136 |
| R-HSA-191859 | snRNP Assembly | 8.991118e-05 | 4.046 |
| R-HSA-194441 | Metabolism of non-coding RNA | 8.991118e-05 | 4.046 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.210811e-04 | 3.917 |
| R-HSA-913531 | Interferon Signaling | 1.215049e-04 | 3.915 |
| R-HSA-432142 | Platelet sensitization by LDL | 1.297851e-04 | 3.887 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.341436e-04 | 3.872 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.502629e-04 | 3.823 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 1.904541e-04 | 3.720 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 2.827673e-04 | 3.549 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 2.827673e-04 | 3.549 |
| R-HSA-68886 | M Phase | 3.173985e-04 | 3.498 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.208142e-04 | 3.494 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.546247e-04 | 3.342 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.507372e-04 | 3.259 |
| R-HSA-70171 | Glycolysis | 5.705773e-04 | 3.244 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 5.823945e-04 | 3.235 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.975793e-04 | 3.224 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.365226e-04 | 3.196 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 6.443876e-04 | 3.191 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 8.462400e-04 | 3.073 |
| R-HSA-2028269 | Signaling by Hippo | 1.199905e-03 | 2.921 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.182218e-03 | 2.927 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.228918e-03 | 2.910 |
| R-HSA-1538133 | G0 and Early G1 | 1.244897e-03 | 2.905 |
| R-HSA-4791275 | Signaling by WNT in cancer | 1.244897e-03 | 2.905 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.244897e-03 | 2.905 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.500956e-03 | 2.824 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.723739e-03 | 2.764 |
| R-HSA-68877 | Mitotic Prometaphase | 1.708934e-03 | 2.767 |
| R-HSA-70326 | Glucose metabolism | 1.780771e-03 | 2.749 |
| R-HSA-201688 | WNT mediated activation of DVL | 2.065689e-03 | 2.685 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.126253e-03 | 2.672 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.173834e-03 | 2.663 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.013041e-03 | 2.696 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.126253e-03 | 2.672 |
| R-HSA-3371556 | Cellular response to heat stress | 2.175707e-03 | 2.662 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.400483e-03 | 2.620 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.513058e-03 | 2.600 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.587015e-03 | 2.587 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.515351e-03 | 2.599 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.834921e-03 | 2.547 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.931701e-03 | 2.533 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.220996e-03 | 2.492 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.648308e-03 | 2.438 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.648308e-03 | 2.438 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.351779e-03 | 2.361 |
| R-HSA-68882 | Mitotic Anaphase | 4.026140e-03 | 2.395 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.160618e-03 | 2.381 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.075719e-03 | 2.390 |
| R-HSA-9679506 | SARS-CoV Infections | 4.455327e-03 | 2.351 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 4.578901e-03 | 2.339 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.740551e-03 | 2.324 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.948431e-03 | 2.306 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.016475e-03 | 2.300 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.389027e-03 | 2.268 |
| R-HSA-75153 | Apoptotic execution phase | 5.539855e-03 | 2.257 |
| R-HSA-2029481 | FCGR activation | 5.930729e-03 | 2.227 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.500867e-03 | 2.187 |
| R-HSA-180024 | DARPP-32 events | 6.248011e-03 | 2.204 |
| R-HSA-5693538 | Homology Directed Repair | 6.559611e-03 | 2.183 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 6.910499e-03 | 2.160 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 6.910499e-03 | 2.160 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 6.990142e-03 | 2.156 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 6.990142e-03 | 2.156 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.454393e-03 | 2.128 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 9.040864e-03 | 2.044 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 8.479753e-03 | 2.072 |
| R-HSA-9664420 | Killing mechanisms | 8.479753e-03 | 2.072 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 8.733196e-03 | 2.059 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 8.479753e-03 | 2.072 |
| R-HSA-168255 | Influenza Infection | 8.664655e-03 | 2.062 |
| R-HSA-1221632 | Meiotic synapsis | 9.084763e-03 | 2.042 |
| R-HSA-69206 | G1/S Transition | 9.146111e-03 | 2.039 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 9.350849e-03 | 2.029 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 9.564319e-03 | 2.019 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.864079e-03 | 2.006 |
| R-HSA-69481 | G2/M Checkpoints | 9.897435e-03 | 2.004 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.028986e-02 | 1.988 |
| R-HSA-111885 | Opioid Signalling | 1.045185e-02 | 1.981 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.095401e-02 | 1.960 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.092406e-02 | 1.962 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.209682e-02 | 1.917 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 1.209682e-02 | 1.917 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.233118e-02 | 1.909 |
| R-HSA-211000 | Gene Silencing by RNA | 1.240441e-02 | 1.906 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.316596e-02 | 1.881 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.330145e-02 | 1.876 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.347351e-02 | 1.871 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 1.380315e-02 | 1.860 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.380315e-02 | 1.860 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.510585e-02 | 1.821 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 1.537074e-02 | 1.813 |
| R-HSA-373753 | Nephrin family interactions | 1.537074e-02 | 1.813 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 1.840091e-02 | 1.735 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.879524e-02 | 1.726 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.879524e-02 | 1.726 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.703461e-02 | 1.769 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 1.739263e-02 | 1.760 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.879524e-02 | 1.726 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.707004e-02 | 1.768 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.707004e-02 | 1.768 |
| R-HSA-9664407 | Parasite infection | 1.707004e-02 | 1.768 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.648395e-02 | 1.783 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 1.879524e-02 | 1.726 |
| R-HSA-72306 | tRNA processing | 1.749369e-02 | 1.757 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.886363e-02 | 1.724 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.924434e-02 | 1.716 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.970635e-02 | 1.705 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 2.034598e-02 | 1.692 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 2.078030e-02 | 1.682 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.115243e-02 | 1.675 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.244471e-02 | 1.649 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.354303e-02 | 1.628 |
| R-HSA-69231 | Cyclin D associated events in G1 | 2.328655e-02 | 1.633 |
| R-HSA-69236 | G1 Phase | 2.328655e-02 | 1.633 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 2.443867e-02 | 1.612 |
| R-HSA-199991 | Membrane Trafficking | 2.188112e-02 | 1.660 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.267645e-02 | 1.644 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 2.196918e-02 | 1.658 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.586836e-02 | 1.587 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 2.579824e-02 | 1.588 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 2.579824e-02 | 1.588 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 2.196918e-02 | 1.658 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 2.196918e-02 | 1.658 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 2.466018e-02 | 1.608 |
| R-HSA-166520 | Signaling by NTRKs | 2.284818e-02 | 1.641 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.429898e-02 | 1.614 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.202325e-02 | 1.657 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.624678e-02 | 1.581 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.624678e-02 | 1.581 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.624678e-02 | 1.581 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.624678e-02 | 1.581 |
| R-HSA-9620244 | Long-term potentiation | 2.680961e-02 | 1.572 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.680961e-02 | 1.572 |
| R-HSA-69275 | G2/M Transition | 2.755332e-02 | 1.560 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 2.802182e-02 | 1.553 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.820615e-02 | 1.550 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.904819e-02 | 1.537 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.942279e-02 | 1.531 |
| R-HSA-9610379 | HCMV Late Events | 2.988419e-02 | 1.525 |
| R-HSA-162587 | HIV Life Cycle | 2.988419e-02 | 1.525 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.139893e-02 | 1.503 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 4.027923e-02 | 1.395 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 4.027923e-02 | 1.395 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 4.027923e-02 | 1.395 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 4.027923e-02 | 1.395 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 4.027923e-02 | 1.395 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 4.027923e-02 | 1.395 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 4.027923e-02 | 1.395 |
| R-HSA-111452 | Activation and oligomerization of BAK protein | 4.027923e-02 | 1.395 |
| R-HSA-114294 | Activation, translocation and oligomerization of BAX | 4.027923e-02 | 1.395 |
| R-HSA-202670 | ERKs are inactivated | 3.873189e-02 | 1.412 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.629582e-02 | 1.440 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 3.873189e-02 | 1.412 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 3.873189e-02 | 1.412 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.791707e-02 | 1.421 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.791707e-02 | 1.421 |
| R-HSA-162906 | HIV Infection | 3.355067e-02 | 1.474 |
| R-HSA-5619102 | SLC transporter disorders | 3.930759e-02 | 1.406 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.172538e-02 | 1.380 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 4.348766e-02 | 1.362 |
| R-HSA-69109 | Leading Strand Synthesis | 4.348766e-02 | 1.362 |
| R-HSA-69091 | Polymerase switching | 4.348766e-02 | 1.362 |
| R-HSA-5578775 | Ion homeostasis | 4.431952e-02 | 1.353 |
| R-HSA-1500620 | Meiosis | 4.453481e-02 | 1.351 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.541573e-02 | 1.343 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 5.980810e-02 | 1.223 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 5.980810e-02 | 1.223 |
| R-HSA-8942233 | Intestinal infectious diseases | 5.980810e-02 | 1.223 |
| R-HSA-69166 | Removal of the Flap Intermediate | 5.360210e-02 | 1.271 |
| R-HSA-390522 | Striated Muscle Contraction | 5.045087e-02 | 1.297 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.024268e-02 | 1.220 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.024268e-02 | 1.220 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 5.894063e-02 | 1.230 |
| R-HSA-180786 | Extension of Telomeres | 5.081542e-02 | 1.294 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.354097e-02 | 1.271 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 5.894063e-02 | 1.230 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.745084e-02 | 1.324 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 5.998661e-02 | 1.222 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.671997e-02 | 1.246 |
| R-HSA-69242 | S Phase | 5.775960e-02 | 1.238 |
| R-HSA-73894 | DNA Repair | 5.295420e-02 | 1.276 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 4.844781e-02 | 1.315 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.780438e-02 | 1.238 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.974390e-02 | 1.303 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 5.980810e-02 | 1.223 |
| R-HSA-9658195 | Leishmania infection | 4.916998e-02 | 1.308 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.916998e-02 | 1.308 |
| R-HSA-111933 | Calmodulin induced events | 5.998661e-02 | 1.222 |
| R-HSA-111997 | CaM pathway | 5.998661e-02 | 1.222 |
| R-HSA-397014 | Muscle contraction | 5.272351e-02 | 1.278 |
| R-HSA-936837 | Ion transport by P-type ATPases | 6.273485e-02 | 1.202 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.745084e-02 | 1.324 |
| R-HSA-69205 | G1/S-Specific Transcription | 5.998661e-02 | 1.222 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 5.894063e-02 | 1.230 |
| R-HSA-8853659 | RET signaling | 5.998661e-02 | 1.222 |
| R-HSA-4641258 | Degradation of DVL | 6.333961e-02 | 1.198 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 6.333961e-02 | 1.198 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 6.445382e-02 | 1.191 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 6.445382e-02 | 1.191 |
| R-HSA-195721 | Signaling by WNT | 6.693650e-02 | 1.174 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.787958e-02 | 1.168 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 7.013240e-02 | 1.154 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 7.053144e-02 | 1.152 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.365066e-02 | 1.133 |
| R-HSA-157579 | Telomere Maintenance | 7.401363e-02 | 1.131 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 7.596741e-02 | 1.119 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 7.596741e-02 | 1.119 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.711024e-02 | 1.113 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.858812e-02 | 1.105 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 7.894075e-02 | 1.103 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 7.894075e-02 | 1.103 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.105515e-02 | 1.091 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 8.135057e-02 | 1.090 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 8.135057e-02 | 1.090 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 8.195018e-02 | 1.086 |
| R-HSA-5358508 | Mismatch Repair | 8.195018e-02 | 1.086 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 8.456932e-02 | 1.073 |
| R-HSA-111996 | Ca-dependent events | 8.519148e-02 | 1.070 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 8.519148e-02 | 1.070 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.572793e-02 | 1.067 |
| R-HSA-162582 | Signal Transduction | 8.582261e-02 | 1.066 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.656331e-02 | 1.063 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 8.752936e-02 | 1.058 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 8.807232e-02 | 1.055 |
| R-HSA-5654743 | Signaling by FGFR4 | 8.910830e-02 | 1.050 |
| R-HSA-1236394 | Signaling by ERBB4 | 9.053903e-02 | 1.043 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 9.067089e-02 | 1.043 |
| R-HSA-380287 | Centrosome maturation | 9.359778e-02 | 1.029 |
| R-HSA-209563 | Axonal growth stimulation | 9.768522e-02 | 1.010 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 9.768522e-02 | 1.010 |
| R-HSA-68911 | G2 Phase | 1.340408e-01 | 0.873 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 9.432572e-02 | 1.025 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 9.432572e-02 | 1.025 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 9.432572e-02 | 1.025 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 9.432572e-02 | 1.025 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.071952e-01 | 0.970 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.341818e-01 | 0.872 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.412207e-01 | 0.850 |
| R-HSA-173623 | Classical antibody-mediated complement activation | 1.412207e-01 | 0.850 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.272964e-01 | 0.895 |
| R-HSA-69186 | Lagging Strand Synthesis | 1.007025e-01 | 0.997 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.137964e-01 | 0.944 |
| R-HSA-191650 | Regulation of gap junction activity | 1.160493e-01 | 0.935 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.172256e-01 | 0.931 |
| R-HSA-420029 | Tight junction interactions | 1.341818e-01 | 0.872 |
| R-HSA-4086400 | PCP/CE pathway | 1.030627e-01 | 0.987 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.320803e-01 | 0.879 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 1.071952e-01 | 0.970 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.274979e-01 | 0.894 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 1.340408e-01 | 0.873 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 1.291870e-01 | 0.889 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.137964e-01 | 0.944 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.232344e-01 | 0.909 |
| R-HSA-5654741 | Signaling by FGFR3 | 9.716307e-02 | 1.012 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.097728e-01 | 0.960 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 1.411488e-01 | 0.850 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 1.160493e-01 | 0.935 |
| R-HSA-447038 | NrCAM interactions | 1.340408e-01 | 0.873 |
| R-HSA-1266695 | Interleukin-7 signaling | 1.341818e-01 | 0.872 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 1.039330e-01 | 0.983 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 1.039330e-01 | 0.983 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 1.197185e-01 | 0.922 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.204991e-01 | 0.919 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 1.291870e-01 | 0.889 |
| R-HSA-1489509 | DAG and IP3 signaling | 9.716307e-02 | 1.012 |
| R-HSA-198753 | ERK/MAPK targets | 1.007025e-01 | 0.997 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.137964e-01 | 0.944 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.302902e-01 | 0.885 |
| R-HSA-418346 | Platelet homeostasis | 9.835536e-02 | 1.007 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.339044e-01 | 0.873 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.071952e-01 | 0.970 |
| R-HSA-9833482 | PKR-mediated signaling | 1.096070e-01 | 0.960 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 1.146695e-01 | 0.941 |
| R-HSA-2262752 | Cellular responses to stress | 1.265609e-01 | 0.898 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.339044e-01 | 0.873 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.461618e-01 | 0.835 |
| R-HSA-165160 | PDE3B signalling | 1.516672e-01 | 0.819 |
| R-HSA-109703 | PKB-mediated events | 1.516672e-01 | 0.819 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.689359e-01 | 0.772 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.689359e-01 | 0.772 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 1.689359e-01 | 0.772 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 1.689359e-01 | 0.772 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 1.858540e-01 | 0.731 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 1.858540e-01 | 0.731 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.858540e-01 | 0.731 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.858540e-01 | 0.731 |
| R-HSA-444257 | RSK activation | 2.024288e-01 | 0.694 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 2.024288e-01 | 0.694 |
| R-HSA-196025 | Formation of annular gap junctions | 2.024288e-01 | 0.694 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 2.024288e-01 | 0.694 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 2.024288e-01 | 0.694 |
| R-HSA-190873 | Gap junction degradation | 2.186672e-01 | 0.660 |
| R-HSA-9700645 | ALK mutants bind TKIs | 2.186672e-01 | 0.660 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 2.345759e-01 | 0.630 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 2.345759e-01 | 0.630 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 2.345759e-01 | 0.630 |
| R-HSA-2022923 | DS-GAG biosynthesis | 2.654310e-01 | 0.576 |
| R-HSA-428540 | Activation of RAC1 | 2.654310e-01 | 0.576 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 2.654310e-01 | 0.576 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 2.803903e-01 | 0.552 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.950459e-01 | 0.530 |
| R-HSA-9006335 | Signaling by Erythropoietin | 1.624796e-01 | 0.789 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.624796e-01 | 0.789 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.065816e-01 | 0.685 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 2.065816e-01 | 0.685 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.517515e-01 | 0.599 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 1.624796e-01 | 0.789 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.486923e-01 | 0.828 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.593219e-01 | 0.586 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.668949e-01 | 0.574 |
| R-HSA-171319 | Telomere Extension By Telomerase | 1.553035e-01 | 0.809 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.279482e-01 | 0.642 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.065816e-01 | 0.685 |
| R-HSA-73886 | Chromosome Maintenance | 1.476468e-01 | 0.831 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 2.024288e-01 | 0.694 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.917150e-01 | 0.717 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 2.803903e-01 | 0.552 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 1.624796e-01 | 0.789 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.540380e-01 | 0.812 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.689359e-01 | 0.772 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.858540e-01 | 0.731 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.917150e-01 | 0.717 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.065816e-01 | 0.685 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.290901e-01 | 0.640 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.991315e-01 | 0.701 |
| R-HSA-69190 | DNA strand elongation | 1.843367e-01 | 0.734 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.843367e-01 | 0.734 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.917150e-01 | 0.717 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.593219e-01 | 0.586 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.895979e-01 | 0.538 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.820360e-01 | 0.550 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.516672e-01 | 0.819 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 1.516672e-01 | 0.819 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.689359e-01 | 0.772 |
| R-HSA-9927354 | Co-stimulation by ICOS | 2.024288e-01 | 0.694 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 2.186672e-01 | 0.660 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 2.345759e-01 | 0.630 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 2.501617e-01 | 0.602 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.654310e-01 | 0.576 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 2.803903e-01 | 0.552 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.803903e-01 | 0.552 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.803903e-01 | 0.552 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.553035e-01 | 0.809 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 1.553035e-01 | 0.809 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.950459e-01 | 0.530 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.950459e-01 | 0.530 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.950459e-01 | 0.530 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.624796e-01 | 0.789 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 2.065816e-01 | 0.685 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.065816e-01 | 0.685 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.917150e-01 | 0.717 |
| R-HSA-69306 | DNA Replication | 2.768847e-01 | 0.558 |
| R-HSA-69239 | Synthesis of DNA | 2.305233e-01 | 0.637 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.858540e-01 | 0.731 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 1.858540e-01 | 0.731 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 2.024288e-01 | 0.694 |
| R-HSA-198203 | PI3K/AKT activation | 2.345759e-01 | 0.630 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.366320e-01 | 0.626 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.172456e-01 | 0.663 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.387482e-01 | 0.622 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 1.516672e-01 | 0.819 |
| R-HSA-446107 | Type I hemidesmosome assembly | 2.024288e-01 | 0.694 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 2.024288e-01 | 0.694 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.132812e-01 | 0.671 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 1.758275e-01 | 0.755 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.716101e-01 | 0.566 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.441809e-01 | 0.612 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.140608e-01 | 0.669 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 2.517515e-01 | 0.599 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 2.517515e-01 | 0.599 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.614621e-01 | 0.583 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 1.516672e-01 | 0.819 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.689359e-01 | 0.772 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.803903e-01 | 0.552 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.803903e-01 | 0.552 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 2.950459e-01 | 0.530 |
| R-HSA-166786 | Creation of C4 and C2 activators | 2.261797e-01 | 0.646 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.937860e-01 | 0.532 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.272639e-01 | 0.643 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.215650e-01 | 0.654 |
| R-HSA-909733 | Interferon alpha/beta signaling | 2.749624e-01 | 0.561 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 2.186672e-01 | 0.660 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 2.654310e-01 | 0.576 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.290901e-01 | 0.640 |
| R-HSA-164944 | Nef and signal transduction | 1.689359e-01 | 0.772 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 2.501617e-01 | 0.602 |
| R-HSA-5682910 | LGI-ADAM interactions | 2.501617e-01 | 0.602 |
| R-HSA-6811438 | Intra-Golgi traffic | 2.668949e-01 | 0.574 |
| R-HSA-9609646 | HCMV Infection | 1.951739e-01 | 0.710 |
| R-HSA-166663 | Initial triggering of complement | 2.659483e-01 | 0.575 |
| R-HSA-186763 | Downstream signal transduction | 1.770014e-01 | 0.752 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.704487e-01 | 0.568 |
| R-HSA-373760 | L1CAM interactions | 2.794887e-01 | 0.554 |
| R-HSA-1474165 | Reproduction | 1.841466e-01 | 0.735 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.516672e-01 | 0.819 |
| R-HSA-9609690 | HCMV Early Events | 1.574304e-01 | 0.803 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.356752e-01 | 0.628 |
| R-HSA-450294 | MAP kinase activation | 1.706386e-01 | 0.768 |
| R-HSA-112043 | PLC beta mediated events | 1.706386e-01 | 0.768 |
| R-HSA-5576891 | Cardiac conduction | 1.876189e-01 | 0.727 |
| R-HSA-210990 | PECAM1 interactions | 2.501617e-01 | 0.602 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.481914e-01 | 0.829 |
| R-HSA-983189 | Kinesins | 1.656508e-01 | 0.781 |
| R-HSA-448424 | Interleukin-17 signaling | 2.172456e-01 | 0.663 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.593219e-01 | 0.586 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.593219e-01 | 0.586 |
| R-HSA-112040 | G-protein mediated events | 2.014024e-01 | 0.696 |
| R-HSA-9607240 | FLT3 Signaling | 2.593219e-01 | 0.586 |
| R-HSA-109581 | Apoptosis | 1.688541e-01 | 0.772 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.803903e-01 | 0.552 |
| R-HSA-9683610 | Maturation of nucleoprotein | 2.950459e-01 | 0.530 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 1.991315e-01 | 0.701 |
| R-HSA-9020558 | Interleukin-2 signaling | 2.501617e-01 | 0.602 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 2.186672e-01 | 0.660 |
| R-HSA-9842663 | Signaling by LTK | 2.803903e-01 | 0.552 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 1.629088e-01 | 0.788 |
| R-HSA-2168880 | Scavenging of heme from plasma | 1.759738e-01 | 0.755 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 1.481914e-01 | 0.829 |
| R-HSA-74160 | Gene expression (Transcription) | 1.742225e-01 | 0.759 |
| R-HSA-109582 | Hemostasis | 1.588222e-01 | 0.799 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.917150e-01 | 0.717 |
| R-HSA-8983711 | OAS antiviral response | 2.803903e-01 | 0.552 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.624796e-01 | 0.789 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.441870e-01 | 0.612 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.517515e-01 | 0.599 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 2.668949e-01 | 0.574 |
| R-HSA-1500931 | Cell-Cell communication | 2.573129e-01 | 0.590 |
| R-HSA-451927 | Interleukin-2 family signaling | 2.517515e-01 | 0.599 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 2.501617e-01 | 0.602 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.563128e-01 | 0.806 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 1.875011e-01 | 0.727 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.967521e-01 | 0.528 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.993507e-01 | 0.524 |
| R-HSA-877300 | Interferon gamma signaling | 3.005069e-01 | 0.522 |
| R-HSA-9675135 | Diseases of DNA repair | 3.046904e-01 | 0.516 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.049211e-01 | 0.516 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 3.094039e-01 | 0.509 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 3.094039e-01 | 0.509 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 3.094039e-01 | 0.509 |
| R-HSA-1433559 | Regulation of KIT signaling | 3.094039e-01 | 0.509 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 3.094039e-01 | 0.509 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 3.094039e-01 | 0.509 |
| R-HSA-5578768 | Physiological factors | 3.094039e-01 | 0.509 |
| R-HSA-9856872 | Malate-aspartate shuttle | 3.094039e-01 | 0.509 |
| R-HSA-391160 | Signal regulatory protein family interactions | 3.094039e-01 | 0.509 |
| R-HSA-8953854 | Metabolism of RNA | 3.102752e-01 | 0.508 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.114606e-01 | 0.507 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.122156e-01 | 0.506 |
| R-HSA-437239 | Recycling pathway of L1 | 3.122156e-01 | 0.506 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.122156e-01 | 0.506 |
| R-HSA-5357801 | Programmed Cell Death | 3.180825e-01 | 0.497 |
| R-HSA-977606 | Regulation of Complement cascade | 3.206652e-01 | 0.494 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.228067e-01 | 0.491 |
| R-HSA-9027284 | Erythropoietin activates RAS | 3.234703e-01 | 0.490 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 3.234703e-01 | 0.490 |
| R-HSA-110312 | Translesion synthesis by REV1 | 3.234703e-01 | 0.490 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 3.234703e-01 | 0.490 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 3.234703e-01 | 0.490 |
| R-HSA-2142712 | Synthesis of 12-eicosatetraenoic acid derivatives | 3.234703e-01 | 0.490 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 3.234703e-01 | 0.490 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 3.234703e-01 | 0.490 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 3.234703e-01 | 0.490 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 3.234703e-01 | 0.490 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 3.234703e-01 | 0.490 |
| R-HSA-196780 | Biotin transport and metabolism | 3.234703e-01 | 0.490 |
| R-HSA-194138 | Signaling by VEGF | 3.252755e-01 | 0.488 |
| R-HSA-73893 | DNA Damage Bypass | 3.272113e-01 | 0.485 |
| R-HSA-157858 | Gap junction trafficking and regulation | 3.272113e-01 | 0.485 |
| R-HSA-73884 | Base Excision Repair | 3.328143e-01 | 0.478 |
| R-HSA-9824446 | Viral Infection Pathways | 3.329566e-01 | 0.478 |
| R-HSA-114608 | Platelet degranulation | 3.345084e-01 | 0.476 |
| R-HSA-109704 | PI3K Cascade | 3.346771e-01 | 0.475 |
| R-HSA-212436 | Generic Transcription Pathway | 3.365724e-01 | 0.473 |
| R-HSA-5656121 | Translesion synthesis by POLI | 3.372511e-01 | 0.472 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 3.372511e-01 | 0.472 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 3.372511e-01 | 0.472 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 3.372511e-01 | 0.472 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.421186e-01 | 0.466 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.495337e-01 | 0.457 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.495402e-01 | 0.457 |
| R-HSA-5655862 | Translesion synthesis by POLK | 3.507519e-01 | 0.455 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 3.507519e-01 | 0.455 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 3.507519e-01 | 0.455 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 3.507519e-01 | 0.455 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.507519e-01 | 0.455 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 3.507519e-01 | 0.455 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 3.569203e-01 | 0.447 |
| R-HSA-9837999 | Mitochondrial protein degradation | 3.606679e-01 | 0.443 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 3.639786e-01 | 0.439 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 3.639786e-01 | 0.439 |
| R-HSA-2142770 | Synthesis of 15-eicosatetraenoic acid derivatives | 3.639786e-01 | 0.439 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 3.639786e-01 | 0.439 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 3.639786e-01 | 0.439 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.639786e-01 | 0.439 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.639786e-01 | 0.439 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.639786e-01 | 0.439 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.668811e-01 | 0.435 |
| R-HSA-3928664 | Ephrin signaling | 3.769366e-01 | 0.424 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.769366e-01 | 0.424 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.769366e-01 | 0.424 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 3.769366e-01 | 0.424 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 3.769366e-01 | 0.424 |
| R-HSA-180292 | GAB1 signalosome | 3.769366e-01 | 0.424 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.769366e-01 | 0.424 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.769366e-01 | 0.424 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.769366e-01 | 0.424 |
| R-HSA-210993 | Tie2 Signaling | 3.769366e-01 | 0.424 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.773040e-01 | 0.423 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.788911e-01 | 0.421 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.788911e-01 | 0.421 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.828306e-01 | 0.417 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.853574e-01 | 0.414 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.853574e-01 | 0.414 |
| R-HSA-112399 | IRS-mediated signalling | 3.861459e-01 | 0.413 |
| R-HSA-190236 | Signaling by FGFR | 3.883462e-01 | 0.411 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.883462e-01 | 0.411 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.883462e-01 | 0.411 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.883462e-01 | 0.411 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 3.895740e-01 | 0.409 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 3.896314e-01 | 0.409 |
| R-HSA-110320 | Translesion Synthesis by POLH | 3.896314e-01 | 0.409 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.896314e-01 | 0.409 |
| R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids | 3.896314e-01 | 0.409 |
| R-HSA-1237112 | Methionine salvage pathway | 3.896314e-01 | 0.409 |
| R-HSA-392517 | Rap1 signalling | 3.896314e-01 | 0.409 |
| R-HSA-9694631 | Maturation of nucleoprotein | 3.896314e-01 | 0.409 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.933635e-01 | 0.405 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.938500e-01 | 0.405 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.991736e-01 | 0.399 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.005425e-01 | 0.397 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.005425e-01 | 0.397 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 4.020683e-01 | 0.396 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 4.020683e-01 | 0.396 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 4.020683e-01 | 0.396 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.034268e-01 | 0.394 |
| R-HSA-167044 | Signalling to RAS | 4.142525e-01 | 0.383 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 4.142525e-01 | 0.383 |
| R-HSA-210991 | Basigin interactions | 4.142525e-01 | 0.383 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4.142525e-01 | 0.383 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 4.142525e-01 | 0.383 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.147792e-01 | 0.382 |
| R-HSA-1268020 | Mitochondrial protein import | 4.218342e-01 | 0.375 |
| R-HSA-186797 | Signaling by PDGF | 4.218342e-01 | 0.375 |
| R-HSA-2022870 | CS-GAG biosynthesis | 4.261892e-01 | 0.370 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 4.261892e-01 | 0.370 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 4.261892e-01 | 0.370 |
| R-HSA-175474 | Assembly Of The HIV Virion | 4.261892e-01 | 0.370 |
| R-HSA-977347 | Serine metabolism | 4.261892e-01 | 0.370 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 4.261892e-01 | 0.370 |
| R-HSA-8848021 | Signaling by PTK6 | 4.288454e-01 | 0.368 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.288454e-01 | 0.368 |
| R-HSA-5617833 | Cilium Assembly | 4.291673e-01 | 0.367 |
| R-HSA-166658 | Complement cascade | 4.311808e-01 | 0.365 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.319706e-01 | 0.365 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.319706e-01 | 0.365 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.358116e-01 | 0.361 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.358116e-01 | 0.361 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 4.378834e-01 | 0.359 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 4.378834e-01 | 0.359 |
| R-HSA-350054 | Notch-HLH transcription pathway | 4.378834e-01 | 0.359 |
| R-HSA-8964038 | LDL clearance | 4.378834e-01 | 0.359 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 4.378834e-01 | 0.359 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.427317e-01 | 0.354 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.427317e-01 | 0.354 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.451251e-01 | 0.352 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.480469e-01 | 0.349 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 4.493399e-01 | 0.347 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.493399e-01 | 0.347 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.493399e-01 | 0.347 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.533655e-01 | 0.344 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.537664e-01 | 0.343 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 4.537664e-01 | 0.343 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 4.564298e-01 | 0.341 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.582496e-01 | 0.339 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 4.586629e-01 | 0.339 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 4.586629e-01 | 0.339 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.605636e-01 | 0.337 |
| R-HSA-429947 | Deadenylation of mRNA | 4.605636e-01 | 0.337 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 4.605636e-01 | 0.337 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.605636e-01 | 0.337 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.605636e-01 | 0.337 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.632059e-01 | 0.334 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 4.699323e-01 | 0.328 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 4.715593e-01 | 0.326 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.715593e-01 | 0.326 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.715593e-01 | 0.326 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.715593e-01 | 0.326 |
| R-HSA-73887 | Death Receptor Signaling | 4.716227e-01 | 0.326 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.744216e-01 | 0.324 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.766081e-01 | 0.322 |
| R-HSA-4839726 | Chromatin organization | 4.768652e-01 | 0.322 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.823314e-01 | 0.317 |
| R-HSA-70635 | Urea cycle | 4.823314e-01 | 0.317 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.823314e-01 | 0.317 |
| R-HSA-72172 | mRNA Splicing | 4.883764e-01 | 0.311 |
| R-HSA-168256 | Immune System | 4.885090e-01 | 0.311 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 4.898053e-01 | 0.310 |
| R-HSA-171306 | Packaging Of Telomere Ends | 4.928847e-01 | 0.307 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 4.928847e-01 | 0.307 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 4.928847e-01 | 0.307 |
| R-HSA-8949613 | Cristae formation | 4.928847e-01 | 0.307 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 4.928847e-01 | 0.307 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.928847e-01 | 0.307 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.928847e-01 | 0.307 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 4.928847e-01 | 0.307 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.928847e-01 | 0.307 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.928847e-01 | 0.307 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.951000e-01 | 0.305 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.963254e-01 | 0.304 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.963254e-01 | 0.304 |
| R-HSA-5688426 | Deubiquitination | 4.980008e-01 | 0.303 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.014959e-01 | 0.300 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 5.027922e-01 | 0.299 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 5.032234e-01 | 0.298 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.052869e-01 | 0.296 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.092054e-01 | 0.293 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5.092054e-01 | 0.293 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 5.133520e-01 | 0.290 |
| R-HSA-9615710 | Late endosomal microautophagy | 5.133520e-01 | 0.290 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 5.133520e-01 | 0.290 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 5.133520e-01 | 0.290 |
| R-HSA-420092 | Glucagon-type ligand receptors | 5.133520e-01 | 0.290 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.153669e-01 | 0.288 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.153669e-01 | 0.288 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.153669e-01 | 0.288 |
| R-HSA-9020591 | Interleukin-12 signaling | 5.155643e-01 | 0.288 |
| R-HSA-418594 | G alpha (i) signalling events | 5.188446e-01 | 0.285 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.190685e-01 | 0.285 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 5.232746e-01 | 0.281 |
| R-HSA-68962 | Activation of the pre-replicative complex | 5.232746e-01 | 0.281 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 5.232746e-01 | 0.281 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 5.232746e-01 | 0.281 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 5.232746e-01 | 0.281 |
| R-HSA-112311 | Neurotransmitter clearance | 5.232746e-01 | 0.281 |
| R-HSA-2424491 | DAP12 signaling | 5.232746e-01 | 0.281 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 5.232746e-01 | 0.281 |
| R-HSA-114452 | Activation of BH3-only proteins | 5.232746e-01 | 0.281 |
| R-HSA-1280218 | Adaptive Immune System | 5.253480e-01 | 0.280 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.302792e-01 | 0.275 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.302792e-01 | 0.275 |
| R-HSA-162588 | Budding and maturation of HIV virion | 5.329956e-01 | 0.273 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 5.329956e-01 | 0.273 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 5.329956e-01 | 0.273 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 5.329956e-01 | 0.273 |
| R-HSA-9659379 | Sensory processing of sound | 5.343116e-01 | 0.272 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.425189e-01 | 0.266 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 5.518486e-01 | 0.258 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.518486e-01 | 0.258 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 5.518486e-01 | 0.258 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.525571e-01 | 0.258 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 5.609886e-01 | 0.251 |
| R-HSA-2024101 | CS/DS degradation | 5.609886e-01 | 0.251 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 5.609886e-01 | 0.251 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.609886e-01 | 0.251 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 5.609886e-01 | 0.251 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 5.609886e-01 | 0.251 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.627717e-01 | 0.250 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 5.699427e-01 | 0.244 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 5.699427e-01 | 0.244 |
| R-HSA-1980145 | Signaling by NOTCH2 | 5.699427e-01 | 0.244 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 5.699427e-01 | 0.244 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.699427e-01 | 0.244 |
| R-HSA-449147 | Signaling by Interleukins | 5.699959e-01 | 0.244 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 5.787148e-01 | 0.238 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 5.787148e-01 | 0.238 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 5.787148e-01 | 0.238 |
| R-HSA-187687 | Signalling to ERKs | 5.787148e-01 | 0.238 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.787148e-01 | 0.238 |
| R-HSA-9843745 | Adipogenesis | 5.826764e-01 | 0.235 |
| R-HSA-2559583 | Cellular Senescence | 5.852985e-01 | 0.233 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.872531e-01 | 0.231 |
| R-HSA-74158 | RNA Polymerase III Transcription | 5.873084e-01 | 0.231 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 5.873084e-01 | 0.231 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.875163e-01 | 0.231 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.888441e-01 | 0.230 |
| R-HSA-110331 | Cleavage of the damaged purine | 5.957273e-01 | 0.225 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 5.957273e-01 | 0.225 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.990200e-01 | 0.223 |
| R-HSA-73927 | Depurination | 6.039749e-01 | 0.219 |
| R-HSA-202424 | Downstream TCR signaling | 6.042234e-01 | 0.219 |
| R-HSA-8939211 | ESR-mediated signaling | 6.093354e-01 | 0.215 |
| R-HSA-163685 | Integration of energy metabolism | 6.096515e-01 | 0.215 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.096778e-01 | 0.215 |
| R-HSA-71336 | Pentose phosphate pathway | 6.120548e-01 | 0.213 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 6.120548e-01 | 0.213 |
| R-HSA-69541 | Stabilization of p53 | 6.120548e-01 | 0.213 |
| R-HSA-201556 | Signaling by ALK | 6.120548e-01 | 0.213 |
| R-HSA-1643685 | Disease | 6.169187e-01 | 0.210 |
| R-HSA-983712 | Ion channel transport | 6.199230e-01 | 0.208 |
| R-HSA-5260271 | Diseases of Immune System | 6.199703e-01 | 0.208 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 6.199703e-01 | 0.208 |
| R-HSA-71240 | Tryptophan catabolism | 6.199703e-01 | 0.208 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.204147e-01 | 0.207 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.256974e-01 | 0.204 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.273675e-01 | 0.202 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 6.277248e-01 | 0.202 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.310550e-01 | 0.200 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 6.353215e-01 | 0.197 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 6.353215e-01 | 0.197 |
| R-HSA-9683701 | Translation of Structural Proteins | 6.353215e-01 | 0.197 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.360919e-01 | 0.196 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 6.427637e-01 | 0.192 |
| R-HSA-73928 | Depyrimidination | 6.427637e-01 | 0.192 |
| R-HSA-6798695 | Neutrophil degranulation | 6.503886e-01 | 0.187 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.562012e-01 | 0.183 |
| R-HSA-190828 | Gap junction trafficking | 6.571968e-01 | 0.182 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 6.571968e-01 | 0.182 |
| R-HSA-2172127 | DAP12 interactions | 6.571968e-01 | 0.182 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 6.600249e-01 | 0.180 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.640040e-01 | 0.178 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 6.641938e-01 | 0.178 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 6.641938e-01 | 0.178 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 6.641938e-01 | 0.178 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 6.641938e-01 | 0.178 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 6.641938e-01 | 0.178 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 6.710484e-01 | 0.173 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.710484e-01 | 0.173 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.710484e-01 | 0.173 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.710484e-01 | 0.173 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.754147e-01 | 0.170 |
| R-HSA-5663205 | Infectious disease | 6.777581e-01 | 0.169 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 6.777636e-01 | 0.169 |
| R-HSA-9609507 | Protein localization | 6.833923e-01 | 0.165 |
| R-HSA-5620924 | Intraflagellar transport | 6.843420e-01 | 0.165 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.907866e-01 | 0.161 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 6.971000e-01 | 0.157 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 6.971000e-01 | 0.157 |
| R-HSA-9748787 | Azathioprine ADME | 6.971000e-01 | 0.157 |
| R-HSA-9675108 | Nervous system development | 6.972280e-01 | 0.157 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.981960e-01 | 0.156 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.005742e-01 | 0.155 |
| R-HSA-9711097 | Cellular response to starvation | 7.019378e-01 | 0.154 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 7.032848e-01 | 0.153 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 7.032848e-01 | 0.153 |
| R-HSA-912446 | Meiotic recombination | 7.032848e-01 | 0.153 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.061380e-01 | 0.151 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.064586e-01 | 0.151 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.069316e-01 | 0.151 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.084650e-01 | 0.150 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 7.093437e-01 | 0.149 |
| R-HSA-72187 | mRNA 3'-end processing | 7.093437e-01 | 0.149 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 7.093437e-01 | 0.149 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 7.093437e-01 | 0.149 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 7.093437e-01 | 0.149 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 7.093437e-01 | 0.149 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.112200e-01 | 0.148 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 7.152793e-01 | 0.146 |
| R-HSA-445355 | Smooth Muscle Contraction | 7.152793e-01 | 0.146 |
| R-HSA-8956320 | Nucleotide biosynthesis | 7.152793e-01 | 0.146 |
| R-HSA-202403 | TCR signaling | 7.154559e-01 | 0.145 |
| R-HSA-72649 | Translation initiation complex formation | 7.210940e-01 | 0.142 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 7.210940e-01 | 0.142 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 7.210940e-01 | 0.142 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 7.210940e-01 | 0.142 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.237715e-01 | 0.140 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.237715e-01 | 0.140 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.256638e-01 | 0.139 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 7.267904e-01 | 0.139 |
| R-HSA-9012852 | Signaling by NOTCH3 | 7.267904e-01 | 0.139 |
| R-HSA-3214815 | HDACs deacetylate histones | 7.267904e-01 | 0.139 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 7.267904e-01 | 0.139 |
| R-HSA-422475 | Axon guidance | 7.286918e-01 | 0.137 |
| R-HSA-8951664 | Neddylation | 7.305337e-01 | 0.136 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 7.323707e-01 | 0.135 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 7.323707e-01 | 0.135 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 7.323707e-01 | 0.135 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 7.323707e-01 | 0.135 |
| R-HSA-75893 | TNF signaling | 7.323707e-01 | 0.135 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 7.323707e-01 | 0.135 |
| R-HSA-177929 | Signaling by EGFR | 7.323707e-01 | 0.135 |
| R-HSA-446728 | Cell junction organization | 7.339288e-01 | 0.134 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.358601e-01 | 0.133 |
| R-HSA-5621480 | Dectin-2 family | 7.378374e-01 | 0.132 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 7.431927e-01 | 0.129 |
| R-HSA-9033241 | Peroxisomal protein import | 7.484390e-01 | 0.126 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 7.484390e-01 | 0.126 |
| R-HSA-186712 | Regulation of beta-cell development | 7.484390e-01 | 0.126 |
| R-HSA-418555 | G alpha (s) signalling events | 7.494526e-01 | 0.125 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 7.533872e-01 | 0.123 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 7.535784e-01 | 0.123 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 7.535784e-01 | 0.123 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 7.535784e-01 | 0.123 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 7.535784e-01 | 0.123 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 7.535784e-01 | 0.123 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 7.535784e-01 | 0.123 |
| R-HSA-1227986 | Signaling by ERBB2 | 7.535784e-01 | 0.123 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.550075e-01 | 0.122 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.557214e-01 | 0.122 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 7.586132e-01 | 0.120 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 7.586132e-01 | 0.120 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 7.586132e-01 | 0.120 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.618637e-01 | 0.118 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.618637e-01 | 0.118 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.635453e-01 | 0.117 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 7.635453e-01 | 0.117 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 7.635453e-01 | 0.117 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 7.635453e-01 | 0.117 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.635453e-01 | 0.117 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.659133e-01 | 0.116 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 7.683770e-01 | 0.114 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.729480e-01 | 0.112 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 7.731103e-01 | 0.112 |
| R-HSA-1234174 | Cellular response to hypoxia | 7.777471e-01 | 0.109 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 7.822894e-01 | 0.107 |
| R-HSA-196807 | Nicotinate metabolism | 7.867392e-01 | 0.104 |
| R-HSA-112316 | Neuronal System | 7.885479e-01 | 0.103 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.995518e-01 | 0.097 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 7.995518e-01 | 0.097 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 7.995518e-01 | 0.097 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 8.036498e-01 | 0.095 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 8.036498e-01 | 0.095 |
| R-HSA-3000178 | ECM proteoglycans | 8.036498e-01 | 0.095 |
| R-HSA-975634 | Retinoid metabolism and transport | 8.036498e-01 | 0.095 |
| R-HSA-1226099 | Signaling by FGFR in disease | 8.154492e-01 | 0.089 |
| R-HSA-8852135 | Protein ubiquitination | 8.192231e-01 | 0.087 |
| R-HSA-917937 | Iron uptake and transport | 8.192231e-01 | 0.087 |
| R-HSA-1980143 | Signaling by NOTCH1 | 8.229200e-01 | 0.085 |
| R-HSA-9694635 | Translation of Structural Proteins | 8.265416e-01 | 0.083 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 8.300893e-01 | 0.081 |
| R-HSA-416482 | G alpha (12/13) signalling events | 8.300893e-01 | 0.081 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.330922e-01 | 0.079 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.341466e-01 | 0.079 |
| R-HSA-388396 | GPCR downstream signalling | 8.351212e-01 | 0.078 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 8.369692e-01 | 0.077 |
| R-HSA-6806834 | Signaling by MET | 8.369692e-01 | 0.077 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 8.403043e-01 | 0.076 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 8.589336e-01 | 0.066 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 8.589336e-01 | 0.066 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.606023e-01 | 0.065 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 8.618206e-01 | 0.065 |
| R-HSA-70268 | Pyruvate metabolism | 8.618206e-01 | 0.065 |
| R-HSA-156902 | Peptide chain elongation | 8.646487e-01 | 0.063 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.646487e-01 | 0.063 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.649171e-01 | 0.063 |
| R-HSA-1236974 | ER-Phagosome pathway | 8.674191e-01 | 0.062 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 8.701329e-01 | 0.060 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 8.727913e-01 | 0.059 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 8.727913e-01 | 0.059 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 8.753955e-01 | 0.058 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.779466e-01 | 0.057 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 8.779466e-01 | 0.057 |
| R-HSA-391251 | Protein folding | 8.779466e-01 | 0.057 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 8.779466e-01 | 0.057 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.828935e-01 | 0.054 |
| R-HSA-1474290 | Collagen formation | 8.828935e-01 | 0.054 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.852915e-01 | 0.053 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.876405e-01 | 0.052 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.876405e-01 | 0.052 |
| R-HSA-5389840 | Mitochondrial translation elongation | 8.899415e-01 | 0.051 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 8.899415e-01 | 0.051 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 8.899415e-01 | 0.051 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 8.899415e-01 | 0.051 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.921956e-01 | 0.050 |
| R-HSA-5368286 | Mitochondrial translation initiation | 8.944037e-01 | 0.048 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.956623e-01 | 0.048 |
| R-HSA-168249 | Innate Immune System | 8.956819e-01 | 0.048 |
| R-HSA-3214847 | HATs acetylate histones | 8.965666e-01 | 0.047 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.965666e-01 | 0.047 |
| R-HSA-5610787 | Hedgehog 'off' state | 8.986854e-01 | 0.046 |
| R-HSA-2408557 | Selenocysteine synthesis | 9.007609e-01 | 0.045 |
| R-HSA-9020702 | Interleukin-1 signaling | 9.007609e-01 | 0.045 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 9.007609e-01 | 0.045 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.009719e-01 | 0.045 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.025964e-01 | 0.045 |
| R-HSA-1483255 | PI Metabolism | 9.027940e-01 | 0.044 |
| R-HSA-157118 | Signaling by NOTCH | 9.033581e-01 | 0.044 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 9.047856e-01 | 0.043 |
| R-HSA-192823 | Viral mRNA Translation | 9.047856e-01 | 0.043 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 9.067365e-01 | 0.043 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 9.141496e-01 | 0.039 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 9.159092e-01 | 0.038 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 9.159092e-01 | 0.038 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 9.159092e-01 | 0.038 |
| R-HSA-372790 | Signaling by GPCR | 9.160942e-01 | 0.038 |
| R-HSA-5419276 | Mitochondrial translation termination | 9.176328e-01 | 0.037 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 9.193212e-01 | 0.037 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.241642e-01 | 0.034 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 9.241821e-01 | 0.034 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.266749e-01 | 0.033 |
| R-HSA-597592 | Post-translational protein modification | 9.298164e-01 | 0.032 |
| R-HSA-1474244 | Extracellular matrix organization | 9.308885e-01 | 0.031 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 9.316434e-01 | 0.031 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 9.316434e-01 | 0.031 |
| R-HSA-1592230 | Mitochondrial biogenesis | 9.330454e-01 | 0.030 |
| R-HSA-6809371 | Formation of the cornified envelope | 9.420885e-01 | 0.026 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.431542e-01 | 0.025 |
| R-HSA-382551 | Transport of small molecules | 9.536089e-01 | 0.021 |
| R-HSA-5368287 | Mitochondrial translation | 9.592983e-01 | 0.018 |
| R-HSA-9948299 | Ribosome-associated quality control | 9.592983e-01 | 0.018 |
| R-HSA-5358351 | Signaling by Hedgehog | 9.592983e-01 | 0.018 |
| R-HSA-6807070 | PTEN Regulation | 9.601344e-01 | 0.018 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.624312e-01 | 0.017 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.649633e-01 | 0.015 |
| R-HSA-72312 | rRNA processing | 9.661671e-01 | 0.015 |
| R-HSA-2187338 | Visual phototransduction | 9.669290e-01 | 0.015 |
| R-HSA-9758941 | Gastrulation | 9.682746e-01 | 0.014 |
| R-HSA-446652 | Interleukin-1 family signaling | 9.701913e-01 | 0.013 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 9.701913e-01 | 0.013 |
| R-HSA-2142753 | Arachidonate metabolism | 9.701913e-01 | 0.013 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 9.714045e-01 | 0.013 |
| R-HSA-9612973 | Autophagy | 9.725685e-01 | 0.012 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.726238e-01 | 0.012 |
| R-HSA-9006936 | Signaling by TGFB family members | 9.747567e-01 | 0.011 |
| R-HSA-421270 | Cell-cell junction organization | 9.757871e-01 | 0.011 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.767708e-01 | 0.010 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.794633e-01 | 0.009 |
| R-HSA-611105 | Respiratory electron transport | 9.829966e-01 | 0.007 |
| R-HSA-3781865 | Diseases of glycosylation | 9.849928e-01 | 0.007 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.858611e-01 | 0.006 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.875575e-01 | 0.005 |
| R-HSA-1483257 | Phospholipid metabolism | 9.890056e-01 | 0.005 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.898977e-01 | 0.004 |
| R-HSA-6805567 | Keratinization | 9.907059e-01 | 0.004 |
| R-HSA-9748784 | Drug ADME | 9.927637e-01 | 0.003 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.947171e-01 | 0.002 |
| R-HSA-15869 | Metabolism of nucleotides | 9.950303e-01 | 0.002 |
| R-HSA-1266738 | Developmental Biology | 9.959328e-01 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.970340e-01 | 0.001 |
| R-HSA-416476 | G alpha (q) signalling events | 9.972324e-01 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.982782e-01 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 9.985900e-01 | 0.001 |
| R-HSA-72766 | Translation | 9.991139e-01 | 0.000 |
| R-HSA-8957322 | Metabolism of steroids | 9.992133e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.997227e-01 | 0.000 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.998080e-01 | 0.000 |
| R-HSA-8978868 | Fatty acid metabolism | 9.998659e-01 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 9.999121e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.900 | 0.578 | 1 | 0.913 |
CLK3 |
0.895 | 0.469 | 1 | 0.843 |
COT |
0.894 | 0.155 | 2 | 0.926 |
NLK |
0.890 | 0.555 | 1 | 0.908 |
JNK2 |
0.885 | 0.663 | 1 | 0.891 |
CDK8 |
0.884 | 0.562 | 1 | 0.894 |
SRPK1 |
0.884 | 0.314 | -3 | 0.745 |
CDK1 |
0.884 | 0.621 | 1 | 0.871 |
MTOR |
0.883 | 0.186 | 1 | 0.788 |
CDK19 |
0.883 | 0.564 | 1 | 0.881 |
DSTYK |
0.882 | 0.106 | 2 | 0.942 |
CDK5 |
0.881 | 0.607 | 1 | 0.899 |
JNK3 |
0.881 | 0.643 | 1 | 0.898 |
P38G |
0.881 | 0.639 | 1 | 0.839 |
CDK18 |
0.880 | 0.600 | 1 | 0.865 |
DYRK2 |
0.880 | 0.543 | 1 | 0.917 |
CDK3 |
0.879 | 0.601 | 1 | 0.847 |
CDK13 |
0.879 | 0.579 | 1 | 0.896 |
ERK5 |
0.878 | 0.286 | 1 | 0.815 |
HIPK4 |
0.877 | 0.339 | 1 | 0.879 |
CDK7 |
0.877 | 0.541 | 1 | 0.904 |
HIPK2 |
0.876 | 0.559 | 1 | 0.890 |
ERK1 |
0.876 | 0.591 | 1 | 0.880 |
CDK17 |
0.875 | 0.599 | 1 | 0.836 |
MOS |
0.874 | 0.052 | 1 | 0.743 |
GCN2 |
0.874 | -0.099 | 2 | 0.861 |
IKKB |
0.874 | -0.077 | -2 | 0.793 |
CDC7 |
0.874 | -0.047 | 1 | 0.692 |
PRPK |
0.874 | -0.084 | -1 | 0.898 |
CDK12 |
0.873 | 0.581 | 1 | 0.888 |
RAF1 |
0.873 | -0.062 | 1 | 0.733 |
P38B |
0.873 | 0.591 | 1 | 0.870 |
CDKL1 |
0.873 | 0.125 | -3 | 0.797 |
P38A |
0.872 | 0.570 | 1 | 0.900 |
HIPK1 |
0.872 | 0.524 | 1 | 0.919 |
ULK2 |
0.872 | -0.069 | 2 | 0.849 |
CLK1 |
0.872 | 0.359 | -3 | 0.734 |
NEK6 |
0.871 | 0.051 | -2 | 0.892 |
SRPK2 |
0.871 | 0.239 | -3 | 0.663 |
TBK1 |
0.871 | -0.093 | 1 | 0.671 |
CDK2 |
0.871 | 0.492 | 1 | 0.878 |
PIM3 |
0.870 | 0.012 | -3 | 0.818 |
CDK16 |
0.870 | 0.603 | 1 | 0.843 |
CLK4 |
0.870 | 0.316 | -3 | 0.757 |
ERK2 |
0.869 | 0.572 | 1 | 0.887 |
CLK2 |
0.869 | 0.383 | -3 | 0.734 |
NEK7 |
0.869 | -0.019 | -3 | 0.870 |
CDK9 |
0.869 | 0.552 | 1 | 0.903 |
P38D |
0.869 | 0.615 | 1 | 0.860 |
BMPR2 |
0.868 | -0.063 | -2 | 0.918 |
TGFBR2 |
0.868 | 0.031 | -2 | 0.883 |
ICK |
0.868 | 0.241 | -3 | 0.826 |
IKKE |
0.868 | -0.097 | 1 | 0.668 |
MST4 |
0.868 | 0.065 | 2 | 0.897 |
CDKL5 |
0.868 | 0.123 | -3 | 0.784 |
SRPK3 |
0.867 | 0.218 | -3 | 0.722 |
PDHK4 |
0.867 | -0.223 | 1 | 0.764 |
CDK10 |
0.866 | 0.574 | 1 | 0.886 |
CDK14 |
0.866 | 0.574 | 1 | 0.890 |
CAMK1B |
0.866 | -0.032 | -3 | 0.856 |
CAMK2G |
0.866 | -0.063 | 2 | 0.852 |
MLK1 |
0.866 | -0.035 | 2 | 0.884 |
DYRK4 |
0.865 | 0.548 | 1 | 0.895 |
PKN3 |
0.865 | 0.001 | -3 | 0.813 |
NDR2 |
0.865 | -0.034 | -3 | 0.817 |
WNK1 |
0.865 | 0.002 | -2 | 0.862 |
NUAK2 |
0.865 | 0.039 | -3 | 0.827 |
ATR |
0.865 | -0.052 | 1 | 0.713 |
PKCD |
0.864 | 0.075 | 2 | 0.863 |
HUNK |
0.864 | -0.041 | 2 | 0.863 |
NIK |
0.863 | -0.009 | -3 | 0.875 |
HIPK3 |
0.863 | 0.477 | 1 | 0.922 |
GRK1 |
0.862 | 0.059 | -2 | 0.844 |
ULK1 |
0.862 | -0.115 | -3 | 0.825 |
NDR1 |
0.862 | -0.036 | -3 | 0.816 |
PDHK1 |
0.862 | -0.207 | 1 | 0.755 |
DYRK1B |
0.862 | 0.513 | 1 | 0.893 |
CHAK2 |
0.861 | -0.004 | -1 | 0.899 |
RSK2 |
0.861 | 0.019 | -3 | 0.757 |
RIPK3 |
0.861 | -0.095 | 3 | 0.786 |
PIM1 |
0.861 | 0.059 | -3 | 0.764 |
PKN2 |
0.861 | 0.002 | -3 | 0.833 |
DYRK1A |
0.860 | 0.411 | 1 | 0.917 |
BMPR1B |
0.860 | 0.136 | 1 | 0.636 |
SKMLCK |
0.860 | -0.014 | -2 | 0.855 |
MARK4 |
0.860 | -0.010 | 4 | 0.838 |
IKKA |
0.859 | -0.040 | -2 | 0.784 |
GRK5 |
0.858 | -0.148 | -3 | 0.864 |
NEK9 |
0.858 | -0.077 | 2 | 0.893 |
CAMLCK |
0.858 | -0.032 | -2 | 0.851 |
P90RSK |
0.858 | -0.007 | -3 | 0.760 |
CDK6 |
0.858 | 0.580 | 1 | 0.888 |
DYRK3 |
0.857 | 0.400 | 1 | 0.916 |
MLK3 |
0.857 | 0.027 | 2 | 0.825 |
PRP4 |
0.856 | 0.352 | -3 | 0.795 |
PRKD1 |
0.856 | -0.028 | -3 | 0.798 |
ALK4 |
0.856 | 0.069 | -2 | 0.913 |
GRK6 |
0.856 | -0.063 | 1 | 0.697 |
BCKDK |
0.856 | -0.164 | -1 | 0.838 |
IRE1 |
0.856 | -0.023 | 1 | 0.686 |
AMPKA1 |
0.856 | -0.037 | -3 | 0.834 |
JNK1 |
0.855 | 0.550 | 1 | 0.868 |
RSK3 |
0.855 | -0.017 | -3 | 0.753 |
ANKRD3 |
0.855 | -0.099 | 1 | 0.752 |
NIM1 |
0.854 | -0.036 | 3 | 0.816 |
DAPK2 |
0.854 | -0.070 | -3 | 0.863 |
PRKD2 |
0.854 | 0.001 | -3 | 0.740 |
PLK1 |
0.854 | -0.014 | -2 | 0.866 |
PKCB |
0.854 | 0.056 | 2 | 0.819 |
LATS2 |
0.853 | -0.046 | -5 | 0.770 |
FAM20C |
0.853 | 0.080 | 2 | 0.671 |
TTBK2 |
0.853 | -0.145 | 2 | 0.761 |
MLK2 |
0.853 | -0.101 | 2 | 0.885 |
PKCG |
0.853 | 0.039 | 2 | 0.818 |
TGFBR1 |
0.853 | 0.080 | -2 | 0.894 |
CDK4 |
0.852 | 0.571 | 1 | 0.878 |
CAMK2D |
0.852 | -0.093 | -3 | 0.826 |
MASTL |
0.852 | -0.245 | -2 | 0.837 |
WNK3 |
0.852 | -0.240 | 1 | 0.715 |
PKACG |
0.852 | -0.030 | -2 | 0.729 |
PKR |
0.852 | 0.037 | 1 | 0.729 |
P70S6KB |
0.852 | -0.030 | -3 | 0.783 |
GRK4 |
0.852 | -0.120 | -2 | 0.881 |
PKCA |
0.852 | 0.052 | 2 | 0.809 |
AURC |
0.851 | 0.039 | -2 | 0.636 |
MLK4 |
0.851 | -0.006 | 2 | 0.806 |
ATM |
0.851 | -0.051 | 1 | 0.657 |
DLK |
0.851 | -0.186 | 1 | 0.711 |
MAPKAPK3 |
0.851 | -0.068 | -3 | 0.751 |
GRK7 |
0.851 | 0.070 | 1 | 0.655 |
TSSK2 |
0.850 | -0.050 | -5 | 0.817 |
IRE2 |
0.850 | -0.027 | 2 | 0.821 |
AMPKA2 |
0.849 | -0.036 | -3 | 0.799 |
NEK2 |
0.849 | -0.032 | 2 | 0.870 |
TSSK1 |
0.848 | -0.027 | -3 | 0.848 |
RIPK1 |
0.848 | -0.198 | 1 | 0.714 |
LATS1 |
0.848 | 0.025 | -3 | 0.831 |
ALK2 |
0.848 | 0.079 | -2 | 0.900 |
YSK4 |
0.848 | -0.091 | 1 | 0.679 |
MNK2 |
0.848 | -0.006 | -2 | 0.771 |
PKCH |
0.848 | 0.008 | 2 | 0.805 |
PKCZ |
0.847 | 0.008 | 2 | 0.849 |
PAK1 |
0.847 | -0.038 | -2 | 0.767 |
ACVR2A |
0.847 | 0.026 | -2 | 0.878 |
DNAPK |
0.847 | -0.001 | 1 | 0.659 |
PHKG1 |
0.847 | -0.046 | -3 | 0.805 |
PAK3 |
0.846 | -0.075 | -2 | 0.770 |
ACVR2B |
0.846 | 0.025 | -2 | 0.890 |
PINK1 |
0.846 | 0.112 | 1 | 0.802 |
MEK1 |
0.846 | -0.120 | 2 | 0.894 |
MAPKAPK2 |
0.845 | -0.033 | -3 | 0.700 |
NUAK1 |
0.845 | -0.044 | -3 | 0.771 |
QIK |
0.845 | -0.086 | -3 | 0.828 |
CAMK2B |
0.845 | -0.036 | 2 | 0.823 |
RSK4 |
0.845 | 0.012 | -3 | 0.721 |
QSK |
0.845 | -0.013 | 4 | 0.816 |
ERK7 |
0.845 | 0.231 | 2 | 0.608 |
VRK2 |
0.844 | -0.077 | 1 | 0.792 |
MSK2 |
0.844 | -0.061 | -3 | 0.730 |
PLK3 |
0.844 | -0.048 | 2 | 0.815 |
SGK3 |
0.844 | 0.022 | -3 | 0.753 |
MNK1 |
0.844 | 0.006 | -2 | 0.787 |
PRKD3 |
0.843 | -0.027 | -3 | 0.732 |
PKACB |
0.843 | 0.030 | -2 | 0.656 |
MAK |
0.843 | 0.372 | -2 | 0.708 |
CHAK1 |
0.843 | -0.098 | 2 | 0.827 |
PERK |
0.843 | -0.049 | -2 | 0.908 |
PAK6 |
0.843 | 0.007 | -2 | 0.694 |
AKT2 |
0.843 | 0.034 | -3 | 0.676 |
CAMK4 |
0.842 | -0.156 | -3 | 0.802 |
MELK |
0.842 | -0.082 | -3 | 0.785 |
PLK4 |
0.842 | -0.071 | 2 | 0.680 |
CAMK2A |
0.842 | -0.038 | 2 | 0.839 |
AURB |
0.841 | -0.005 | -2 | 0.636 |
BMPR1A |
0.841 | 0.091 | 1 | 0.620 |
MARK3 |
0.841 | 0.001 | 4 | 0.782 |
HRI |
0.841 | -0.091 | -2 | 0.901 |
MST3 |
0.841 | 0.054 | 2 | 0.895 |
TLK2 |
0.841 | -0.079 | 1 | 0.677 |
BRAF |
0.841 | -0.041 | -4 | 0.854 |
MEKK2 |
0.841 | -0.017 | 2 | 0.872 |
MEKK3 |
0.841 | -0.092 | 1 | 0.705 |
SIK |
0.840 | -0.038 | -3 | 0.741 |
ZAK |
0.840 | -0.078 | 1 | 0.690 |
MEKK1 |
0.839 | -0.087 | 1 | 0.722 |
PIM2 |
0.839 | 0.022 | -3 | 0.732 |
PKG2 |
0.838 | -0.018 | -2 | 0.653 |
NEK5 |
0.838 | -0.027 | 1 | 0.713 |
SMG1 |
0.838 | -0.112 | 1 | 0.670 |
MOK |
0.838 | 0.350 | 1 | 0.872 |
MSK1 |
0.838 | -0.032 | -3 | 0.734 |
MARK2 |
0.838 | -0.030 | 4 | 0.740 |
MYLK4 |
0.837 | -0.056 | -2 | 0.772 |
PRKX |
0.837 | 0.048 | -3 | 0.660 |
MEK5 |
0.837 | -0.156 | 2 | 0.884 |
PKCT |
0.837 | 0.003 | 2 | 0.811 |
PAK2 |
0.837 | -0.105 | -2 | 0.757 |
BRSK1 |
0.837 | -0.080 | -3 | 0.774 |
MPSK1 |
0.836 | 0.074 | 1 | 0.710 |
DCAMKL1 |
0.836 | -0.022 | -3 | 0.762 |
TAO3 |
0.836 | 0.013 | 1 | 0.708 |
GSK3A |
0.836 | 0.139 | 4 | 0.450 |
BRSK2 |
0.836 | -0.118 | -3 | 0.797 |
IRAK4 |
0.835 | -0.066 | 1 | 0.690 |
DRAK1 |
0.835 | -0.122 | 1 | 0.630 |
WNK4 |
0.835 | -0.099 | -2 | 0.849 |
GRK2 |
0.834 | -0.089 | -2 | 0.764 |
AKT1 |
0.834 | 0.025 | -3 | 0.692 |
AURA |
0.833 | -0.039 | -2 | 0.614 |
TLK1 |
0.833 | -0.096 | -2 | 0.896 |
MARK1 |
0.833 | -0.059 | 4 | 0.800 |
CK1E |
0.833 | -0.012 | -3 | 0.573 |
CAMK1G |
0.832 | -0.063 | -3 | 0.748 |
PKCI |
0.832 | 0.016 | 2 | 0.820 |
CHK1 |
0.831 | -0.115 | -3 | 0.790 |
NEK8 |
0.831 | -0.065 | 2 | 0.878 |
PKCE |
0.831 | 0.059 | 2 | 0.804 |
PHKG2 |
0.831 | -0.060 | -3 | 0.785 |
SNRK |
0.831 | -0.214 | 2 | 0.729 |
GAK |
0.830 | 0.050 | 1 | 0.735 |
NEK11 |
0.830 | -0.093 | 1 | 0.719 |
TAO2 |
0.829 | -0.024 | 2 | 0.906 |
DCAMKL2 |
0.829 | -0.054 | -3 | 0.789 |
MAPKAPK5 |
0.828 | -0.157 | -3 | 0.709 |
SSTK |
0.828 | -0.025 | 4 | 0.802 |
GSK3B |
0.828 | 0.011 | 4 | 0.440 |
SMMLCK |
0.828 | -0.066 | -3 | 0.813 |
TNIK |
0.828 | 0.078 | 3 | 0.905 |
LKB1 |
0.827 | -0.021 | -3 | 0.846 |
TTBK1 |
0.827 | -0.172 | 2 | 0.676 |
PKACA |
0.826 | -0.004 | -2 | 0.601 |
NEK4 |
0.826 | -0.048 | 1 | 0.698 |
PDK1 |
0.826 | -0.048 | 1 | 0.731 |
CK1G1 |
0.826 | -0.051 | -3 | 0.574 |
CAMKK1 |
0.826 | -0.120 | -2 | 0.787 |
HGK |
0.826 | 0.019 | 3 | 0.903 |
GCK |
0.826 | 0.003 | 1 | 0.707 |
EEF2K |
0.825 | 0.022 | 3 | 0.890 |
CK1D |
0.824 | -0.002 | -3 | 0.523 |
MINK |
0.824 | -0.005 | 1 | 0.697 |
PASK |
0.824 | -0.069 | -3 | 0.842 |
MST2 |
0.824 | -0.058 | 1 | 0.704 |
P70S6K |
0.822 | -0.077 | -3 | 0.697 |
MAP3K15 |
0.822 | -0.065 | 1 | 0.691 |
HPK1 |
0.822 | -0.000 | 1 | 0.704 |
CAMKK2 |
0.822 | -0.120 | -2 | 0.777 |
MEKK6 |
0.821 | -0.075 | 1 | 0.696 |
AKT3 |
0.821 | 0.028 | -3 | 0.610 |
NEK1 |
0.821 | -0.025 | 1 | 0.699 |
PKN1 |
0.821 | -0.023 | -3 | 0.714 |
PAK5 |
0.821 | -0.055 | -2 | 0.620 |
IRAK1 |
0.821 | -0.247 | -1 | 0.808 |
TAK1 |
0.821 | -0.073 | 1 | 0.707 |
KHS2 |
0.820 | 0.079 | 1 | 0.713 |
LRRK2 |
0.820 | -0.041 | 2 | 0.897 |
GRK3 |
0.820 | -0.087 | -2 | 0.727 |
KHS1 |
0.820 | 0.042 | 1 | 0.704 |
CK1A2 |
0.819 | -0.030 | -3 | 0.522 |
PAK4 |
0.819 | -0.039 | -2 | 0.626 |
SGK1 |
0.818 | 0.026 | -3 | 0.596 |
DAPK3 |
0.817 | -0.051 | -3 | 0.784 |
PLK2 |
0.817 | -0.027 | -3 | 0.803 |
CAMK1D |
0.817 | -0.067 | -3 | 0.665 |
LOK |
0.817 | -0.048 | -2 | 0.770 |
MST1 |
0.817 | -0.058 | 1 | 0.688 |
CK2A2 |
0.815 | -0.010 | 1 | 0.542 |
YSK1 |
0.815 | -0.037 | 2 | 0.868 |
STK33 |
0.814 | -0.112 | 2 | 0.673 |
MRCKB |
0.814 | -0.001 | -3 | 0.725 |
ROCK2 |
0.814 | 0.010 | -3 | 0.771 |
HASPIN |
0.813 | 0.095 | -1 | 0.811 |
PDHK3_TYR |
0.812 | 0.199 | 4 | 0.886 |
PBK |
0.812 | -0.005 | 1 | 0.677 |
CHK2 |
0.812 | -0.043 | -3 | 0.621 |
SLK |
0.811 | -0.082 | -2 | 0.723 |
VRK1 |
0.810 | -0.189 | 2 | 0.887 |
MEK2 |
0.810 | -0.195 | 2 | 0.861 |
DAPK1 |
0.810 | -0.067 | -3 | 0.772 |
TTK |
0.810 | 0.020 | -2 | 0.884 |
SBK |
0.809 | 0.047 | -3 | 0.550 |
MRCKA |
0.809 | -0.036 | -3 | 0.739 |
NEK3 |
0.808 | -0.094 | 1 | 0.693 |
RIPK2 |
0.808 | -0.257 | 1 | 0.662 |
DMPK1 |
0.808 | 0.036 | -3 | 0.745 |
OSR1 |
0.807 | -0.028 | 2 | 0.862 |
CAMK1A |
0.807 | -0.053 | -3 | 0.637 |
BUB1 |
0.806 | 0.001 | -5 | 0.749 |
CK2A1 |
0.805 | -0.032 | 1 | 0.520 |
TESK1_TYR |
0.803 | -0.008 | 3 | 0.909 |
PDHK4_TYR |
0.803 | 0.062 | 2 | 0.921 |
PKMYT1_TYR |
0.803 | 0.060 | 3 | 0.882 |
MYO3B |
0.802 | -0.001 | 2 | 0.880 |
MAP2K6_TYR |
0.802 | 0.040 | -1 | 0.914 |
MAP2K4_TYR |
0.802 | -0.016 | -1 | 0.914 |
ROCK1 |
0.801 | -0.005 | -3 | 0.738 |
ASK1 |
0.801 | -0.093 | 1 | 0.681 |
BIKE |
0.801 | 0.018 | 1 | 0.653 |
MYO3A |
0.800 | -0.018 | 1 | 0.705 |
MAP2K7_TYR |
0.800 | -0.127 | 2 | 0.906 |
LIMK2_TYR |
0.799 | 0.066 | -3 | 0.882 |
BMPR2_TYR |
0.799 | 0.013 | -1 | 0.894 |
TAO1 |
0.798 | -0.067 | 1 | 0.663 |
PINK1_TYR |
0.797 | -0.116 | 1 | 0.732 |
PKG1 |
0.797 | -0.069 | -2 | 0.562 |
PDHK1_TYR |
0.796 | -0.074 | -1 | 0.909 |
CRIK |
0.794 | -0.018 | -3 | 0.683 |
ALPHAK3 |
0.794 | -0.069 | -1 | 0.808 |
LIMK1_TYR |
0.792 | -0.080 | 2 | 0.903 |
RET |
0.792 | -0.148 | 1 | 0.716 |
EPHA6 |
0.791 | -0.041 | -1 | 0.862 |
TYK2 |
0.791 | -0.164 | 1 | 0.713 |
JAK2 |
0.789 | -0.120 | 1 | 0.723 |
ROS1 |
0.789 | -0.116 | 3 | 0.821 |
MST1R |
0.788 | -0.151 | 3 | 0.845 |
YANK3 |
0.788 | -0.092 | 2 | 0.438 |
CSF1R |
0.788 | -0.094 | 3 | 0.827 |
AAK1 |
0.787 | 0.060 | 1 | 0.579 |
TYRO3 |
0.786 | -0.178 | 3 | 0.842 |
EPHB4 |
0.785 | -0.123 | -1 | 0.841 |
JAK3 |
0.784 | -0.127 | 1 | 0.691 |
TNNI3K_TYR |
0.784 | 0.001 | 1 | 0.723 |
DDR1 |
0.783 | -0.194 | 4 | 0.804 |
STLK3 |
0.783 | -0.200 | 1 | 0.656 |
ABL2 |
0.783 | -0.096 | -1 | 0.825 |
TXK |
0.782 | -0.026 | 1 | 0.661 |
YES1 |
0.782 | -0.094 | -1 | 0.847 |
JAK1 |
0.782 | -0.051 | 1 | 0.686 |
CK1A |
0.781 | -0.067 | -3 | 0.436 |
NEK10_TYR |
0.781 | -0.104 | 1 | 0.620 |
INSRR |
0.781 | -0.130 | 3 | 0.790 |
FGR |
0.781 | -0.164 | 1 | 0.690 |
LCK |
0.779 | -0.049 | -1 | 0.817 |
FGFR2 |
0.779 | -0.119 | 3 | 0.825 |
TNK2 |
0.779 | -0.111 | 3 | 0.787 |
TNK1 |
0.779 | -0.083 | 3 | 0.817 |
KDR |
0.779 | -0.105 | 3 | 0.793 |
BLK |
0.778 | -0.016 | -1 | 0.825 |
HCK |
0.778 | -0.131 | -1 | 0.819 |
FER |
0.778 | -0.201 | 1 | 0.702 |
KIT |
0.778 | -0.134 | 3 | 0.824 |
FLT3 |
0.778 | -0.158 | 3 | 0.838 |
ABL1 |
0.777 | -0.134 | -1 | 0.818 |
PDGFRB |
0.776 | -0.218 | 3 | 0.842 |
WEE1_TYR |
0.776 | -0.055 | -1 | 0.784 |
EPHA4 |
0.776 | -0.105 | 2 | 0.812 |
TEK |
0.776 | -0.113 | 3 | 0.778 |
ITK |
0.776 | -0.130 | -1 | 0.803 |
SRMS |
0.775 | -0.164 | 1 | 0.682 |
FGFR1 |
0.775 | -0.138 | 3 | 0.804 |
EPHB1 |
0.774 | -0.182 | 1 | 0.689 |
MET |
0.772 | -0.140 | 3 | 0.812 |
EPHB2 |
0.771 | -0.147 | -1 | 0.810 |
TEC |
0.771 | -0.126 | -1 | 0.742 |
EPHB3 |
0.771 | -0.179 | -1 | 0.819 |
BMX |
0.770 | -0.104 | -1 | 0.725 |
FYN |
0.770 | -0.045 | -1 | 0.790 |
FLT1 |
0.769 | -0.139 | -1 | 0.835 |
FGFR3 |
0.769 | -0.123 | 3 | 0.797 |
AXL |
0.769 | -0.227 | 3 | 0.803 |
MERTK |
0.769 | -0.188 | 3 | 0.802 |
BTK |
0.768 | -0.240 | -1 | 0.769 |
ALK |
0.768 | -0.195 | 3 | 0.770 |
PDGFRA |
0.768 | -0.282 | 3 | 0.844 |
DDR2 |
0.767 | -0.076 | 3 | 0.779 |
ERBB2 |
0.765 | -0.204 | 1 | 0.653 |
FRK |
0.765 | -0.152 | -1 | 0.826 |
LTK |
0.765 | -0.212 | 3 | 0.785 |
PTK6 |
0.764 | -0.258 | -1 | 0.746 |
CK1G3 |
0.764 | -0.065 | -3 | 0.391 |
FLT4 |
0.764 | -0.203 | 3 | 0.783 |
EPHA7 |
0.764 | -0.158 | 2 | 0.819 |
LYN |
0.763 | -0.137 | 3 | 0.756 |
NTRK1 |
0.763 | -0.270 | -1 | 0.830 |
INSR |
0.762 | -0.208 | 3 | 0.766 |
EPHA1 |
0.761 | -0.215 | 3 | 0.793 |
NTRK2 |
0.761 | -0.270 | 3 | 0.788 |
EPHA3 |
0.760 | -0.210 | 2 | 0.787 |
MATK |
0.760 | -0.143 | -1 | 0.762 |
EGFR |
0.760 | -0.121 | 1 | 0.571 |
NTRK3 |
0.759 | -0.197 | -1 | 0.782 |
SRC |
0.758 | -0.126 | -1 | 0.795 |
PTK2B |
0.758 | -0.152 | -1 | 0.782 |
FGFR4 |
0.757 | -0.124 | -1 | 0.780 |
EPHA8 |
0.756 | -0.149 | -1 | 0.800 |
EPHA5 |
0.755 | -0.165 | 2 | 0.801 |
YANK2 |
0.755 | -0.119 | 2 | 0.460 |
SYK |
0.754 | -0.057 | -1 | 0.766 |
PTK2 |
0.753 | -0.061 | -1 | 0.779 |
CSK |
0.752 | -0.215 | 2 | 0.820 |
MUSK |
0.748 | -0.191 | 1 | 0.555 |
IGF1R |
0.747 | -0.191 | 3 | 0.705 |
ERBB4 |
0.745 | -0.115 | 1 | 0.569 |
CK1G2 |
0.744 | -0.071 | -3 | 0.488 |
EPHA2 |
0.744 | -0.164 | -1 | 0.764 |
ZAP70 |
0.735 | -0.071 | -1 | 0.709 |
FES |
0.730 | -0.216 | -1 | 0.706 |