Motif 701 (n=48)

Position-wise Probabilities

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uniprot genes site source protein function
O00444 PLK4 S22 psp Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}.
P02042 HBD S73 ochoa Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain) Involved in oxygen transport from the lung to the various peripheral tissues.
P04049 RAF1 S359 psp RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P06213 INSR S1033 psp Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}.
P08069 IGF1R S1009 ochoa Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
P13861 PRKAR2A S205 ochoa cAMP-dependent protein kinase type II-alpha regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
P15056 BRAF S467 psp Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.
P17612 PRKACA S54 ochoa cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}.
P20340 RAB6A S23 ochoa Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}.
P21127 CDK11B T448 ochoa Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}.
P22694 PRKACB S54 ochoa cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}.
P31323 PRKAR2B S220 ochoa cAMP-dependent protein kinase type II-beta regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
P48634 PRRC2A S46 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P51812 RPS6KA3 S78 ochoa Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.
P60709 ACTB Y53 ochoa|psp Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P62736 ACTA2 Y55 ochoa Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P63261 ACTG1 Y53 ochoa Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}.
P63267 ACTG2 Y54 ochoa Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68032 ACTC1 Y55 ochoa|psp Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68133 ACTA1 Y55 ochoa Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68871 HBB S73 ochoa Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] Involved in oxygen transport from the lung to the various peripheral tissues. {ECO:0000269|PubMed:28066926}.; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
Q00536 CDK16 T175 ochoa|psp Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.
Q00537 CDK17 T202 ochoa Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}.
Q05655 PRKCD S359 psp Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}.
Q13043 STK4 S40 psp Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}.
Q15418 RPS6KA1 S72 ochoa Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}.
Q5JSZ5 PRRC2B S47 ochoa Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) None
Q99640 PKMYT1 S120 ochoa Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}.
Q9NRW1 RAB6B S23 ochoa Ras-related protein Rab-6B (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (By similarity). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866). {ECO:0000250|UniProtKB:P20340, ECO:0000269|PubMed:17707369, ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:26209634}.
Q9P289 STK26 S34 ochoa Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}.
Q9UK32 RPS6KA6 S83 ochoa Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}.
Q9UQ88 CDK11A T436 ochoa Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}.
Q9Y520 PRRC2C S44 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
O00506 STK25 S30 Sugiyama Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}.
O15357 INPPL1 S189 Sugiyama Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}.
P14616 INSRR S989 Sugiyama Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. {ECO:0000269|PubMed:21641549}.
P22612 PRKACG S54 Sugiyama cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11) Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
P49760 CLK2 T173 Sugiyama Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.
P50750 CDK9 T29 Sugiyama Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit) Protein kinase involved in the regulation of transcription (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094, PubMed:29335245). Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:16427012, PubMed:20930849, PubMed:28426094, PubMed:30134174). This complex is inactive when in the 7SK snRNP complex form (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094). Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE (PubMed:10912001, PubMed:11112772, PubMed:12037670, PubMed:16427012, PubMed:20081228, PubMed:20980437, PubMed:21127351, PubMed:9857195). Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling) (PubMed:17956865, PubMed:18362169). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis (PubMed:10393184, PubMed:11112772). P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export (PubMed:15564463, PubMed:19575011, PubMed:19844166). Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing (PubMed:15564463, PubMed:19575011, PubMed:19844166). The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro (PubMed:21127351). Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage (PubMed:20493174). In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6 (PubMed:20493174). Promotes cardiac myocyte enlargement (PubMed:20081228). RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription (PubMed:21127351). AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect (PubMed:10912001, PubMed:11112772, PubMed:9857195). The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation (PubMed:12037670). Catalyzes phosphorylation of KAT5, promoting KAT5 recruitment to chromatin and histone acetyltransferase activity (PubMed:29335245). {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11145967, ECO:0000269|PubMed:11575923, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:11884399, ECO:0000269|PubMed:12037670, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15564463, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:17956865, ECO:0000269|PubMed:18362169, ECO:0000269|PubMed:19575011, ECO:0000269|PubMed:19844166, ECO:0000269|PubMed:20081228, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:20930849, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:28426094, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:9857195}.
Q12851 MAP4K2 T26 Sugiyama Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}.
Q13188 STK3 S37 Sugiyama Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}.
Q8NG66 NEK11 S39 Sugiyama Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}.
Q99558 MAP3K14 S410 Sugiyama Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:25406581}.
Q6ZN16 MAP3K15 T662 Sugiyama Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway (PubMed:20362554, PubMed:26732173). Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases (PubMed:20362554, PubMed:26732173). May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis (PubMed:20362554). Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade (PubMed:26732173). {ECO:0000269|PubMed:20362554, ECO:0000269|PubMed:26732173}.
Q99683 MAP3K5 T690 Sugiyama Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}.
Q9Y6E0 STK24 S46 Sugiyama Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}.
Q7L7X3 TAOK1 S38 Sugiyama Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}.
Q9UL54 TAOK2 S38 Sugiyama Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}.
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reactome_id name p -log10_p
R-HSA-111933 Calmodulin induced events 2.002301e-10 9.698
R-HSA-111997 CaM pathway 2.002301e-10 9.698
R-HSA-9010642 ROBO receptors bind AKAP5 5.519060e-10 9.258
R-HSA-111996 Ca-dependent events 5.648606e-10 9.248
R-HSA-1489509 DAG and IP3 signaling 8.425800e-10 9.074
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 1.383406e-09 8.859
R-HSA-438064 Post NMDA receptor activation events 1.756989e-09 8.755
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 4.789290e-09 8.320
R-HSA-112043 PLC beta mediated events 5.118099e-09 8.291
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 4.329780e-09 8.364
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 6.188994e-09 8.208
R-HSA-112040 G-protein mediated events 9.029214e-09 8.044
R-HSA-163615 PKA activation 2.136936e-08 7.670
R-HSA-164378 PKA activation in glucagon signalling 2.136936e-08 7.670
R-HSA-4420097 VEGFA-VEGFR2 Pathway 1.711002e-08 7.767
R-HSA-3000171 Non-integrin membrane-ECM interactions 1.796836e-08 7.745
R-HSA-194138 Signaling by VEGF 3.197884e-08 7.495
R-HSA-111931 PKA-mediated phosphorylation of CREB 3.913654e-08 7.407
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 1.099284e-07 6.959
R-HSA-9764561 Regulation of CDH1 Function 1.181341e-07 6.928
R-HSA-111885 Opioid Signalling 1.617341e-07 6.791
R-HSA-180024 DARPP-32 events 1.689457e-07 6.772
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 2.095882e-07 6.679
R-HSA-163359 Glucagon signaling in metabolic regulation 3.250729e-07 6.488
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 9.662306e-07 6.015
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 1.282849e-06 5.892
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 1.282849e-06 5.892
R-HSA-437239 Recycling pathway of L1 1.535749e-06 5.814
R-HSA-9634597 GPER1 signaling 1.676109e-06 5.776
R-HSA-392517 Rap1 signalling 1.703407e-06 5.769
R-HSA-422356 Regulation of insulin secretion 2.336734e-06 5.631
R-HSA-112315 Transmission across Chemical Synapses 2.765131e-06 5.558
R-HSA-109582 Hemostasis 3.016578e-06 5.520
R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors 3.332502e-06 5.477
R-HSA-422475 Axon guidance 3.478665e-06 5.459
R-HSA-5621575 CD209 (DC-SIGN) signaling 4.094843e-06 5.388
R-HSA-445717 Aquaporin-mediated transport 4.599695e-06 5.337
R-HSA-9675108 Nervous system development 6.336616e-06 5.198
R-HSA-444257 RSK activation 8.599354e-06 5.066
R-HSA-162582 Signal Transduction 9.753165e-06 5.011
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 9.935258e-06 5.003
R-HSA-380287 Centrosome maturation 1.116495e-05 4.952
R-HSA-163685 Integration of energy metabolism 1.589886e-05 4.799
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 1.476252e-05 4.831
R-HSA-8853659 RET signaling 1.671365e-05 4.777
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 1.827634e-05 4.738
R-HSA-9656223 Signaling by RAF1 mutants 2.775033e-05 4.557
R-HSA-5674135 MAP2K and MAPK activation 2.775033e-05 4.557
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 4.040787e-05 4.394
R-HSA-9649948 Signaling downstream of RAS mutants 4.040787e-05 4.394
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 4.040787e-05 4.394
R-HSA-6802949 Signaling by RAS mutants 4.040787e-05 4.394
R-HSA-5683057 MAPK family signaling cascades 3.896022e-05 4.409
R-HSA-8963896 HDL assembly 3.703510e-05 4.431
R-HSA-9006925 Intracellular signaling by second messengers 3.537979e-05 4.451
R-HSA-5610787 Hedgehog 'off' state 4.436748e-05 4.353
R-HSA-112316 Neuronal System 4.564769e-05 4.341
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 5.055297e-05 4.296
R-HSA-9860931 Response of endothelial cells to shear stress 5.240435e-05 4.281
R-HSA-5621481 C-type lectin receptors (CLRs) 5.284521e-05 4.277
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 5.597342e-05 4.252
R-HSA-9764265 Regulation of CDH1 Expression and Function 5.597342e-05 4.252
R-HSA-69275 G2/M Transition 8.010998e-05 4.096
R-HSA-9855142 Cellular responses to mechanical stimuli 8.038247e-05 4.095
R-HSA-9658195 Leishmania infection 8.286340e-05 4.082
R-HSA-9824443 Parasitic Infection Pathways 8.286340e-05 4.082
R-HSA-453274 Mitotic G2-G2/M phases 8.446491e-05 4.073
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 8.649942e-05 4.063
R-HSA-373760 L1CAM interactions 9.299416e-05 4.032
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 1.038122e-04 3.984
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.285123e-04 3.891
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 1.356034e-04 3.868
R-HSA-8963898 Plasma lipoprotein assembly 1.664682e-04 3.779
R-HSA-5358351 Signaling by Hedgehog 2.098211e-04 3.678
R-HSA-418990 Adherens junctions interactions 1.796920e-04 3.745
R-HSA-1474244 Extracellular matrix organization 2.126052e-04 3.672
R-HSA-6802957 Oncogenic MAPK signaling 3.215561e-04 3.493
R-HSA-5687128 MAPK6/MAPK4 signaling 3.215561e-04 3.493
R-HSA-111465 Apoptotic cleavage of cellular proteins 3.317233e-04 3.479
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 3.577270e-04 3.446
R-HSA-421270 Cell-cell junction organization 3.587569e-04 3.445
R-HSA-5674499 Negative feedback regulation of MAPK pathway 3.733594e-04 3.428
R-HSA-199920 CREB phosphorylation 4.714798e-04 3.327
R-HSA-163560 Triglyceride catabolism 4.747837e-04 3.324
R-HSA-418555 G alpha (s) signalling events 5.296990e-04 3.276
R-HSA-9664433 Leishmania parasite growth and survival 5.552480e-04 3.256
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 5.552480e-04 3.256
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 5.807769e-04 3.236
R-HSA-446728 Cell junction organization 5.903848e-04 3.229
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 6.922791e-04 3.160
R-HSA-5610783 Degradation of GLI2 by the proteasome 6.922791e-04 3.160
R-HSA-5610780 Degradation of GLI1 by the proteasome 6.922791e-04 3.160
R-HSA-418594 G alpha (i) signalling events 6.938090e-04 3.159
R-HSA-196025 Formation of annular gap junctions 7.011746e-04 3.154
R-HSA-9660537 Signaling by MRAS-complex mutants 7.011746e-04 3.154
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 7.011746e-04 3.154
R-HSA-190873 Gap junction degradation 8.325973e-04 3.080
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 8.325973e-04 3.080
R-HSA-69278 Cell Cycle, Mitotic 9.270403e-04 3.033
R-HSA-75153 Apoptotic execution phase 9.152645e-04 3.038
R-HSA-1640170 Cell Cycle 8.753278e-04 3.058
R-HSA-376176 Signaling by ROBO receptors 1.060620e-03 2.974
R-HSA-1500931 Cell-Cell communication 1.096621e-03 2.960
R-HSA-397014 Muscle contraction 1.287798e-03 2.890
R-HSA-388396 GPCR downstream signalling 1.600514e-03 2.796
R-HSA-8979227 Triglyceride metabolism 1.693375e-03 2.771
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 1.995496e-03 2.700
R-HSA-380259 Loss of Nlp from mitotic centrosomes 1.995496e-03 2.700
R-HSA-168249 Innate Immune System 2.036661e-03 2.691
R-HSA-446353 Cell-extracellular matrix interactions 2.054982e-03 2.687
R-HSA-8854518 AURKA Activation by TPX2 2.242760e-03 2.649
R-HSA-2028269 Signaling by Hippo 2.736828e-03 2.563
R-HSA-372790 Signaling by GPCR 3.132433e-03 2.504
R-HSA-198753 ERK/MAPK targets 3.788672e-03 2.422
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 3.788672e-03 2.422
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 4.124267e-03 2.385
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 6.729783e-03 2.172
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 4.775287e-03 2.321
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 5.052091e-03 2.297
R-HSA-445095 Interaction between L1 and Ankyrins 6.009234e-03 2.221
R-HSA-5218921 VEGFR2 mediated cell proliferation 5.326498e-03 2.274
R-HSA-68877 Mitotic Prometaphase 6.403759e-03 2.194
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 6.729783e-03 2.172
R-HSA-2682334 EPH-Ephrin signaling 5.485158e-03 2.261
R-HSA-8953897 Cellular responses to stimuli 6.466992e-03 2.189
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 5.485158e-03 2.261
R-HSA-70171 Glycolysis 6.915669e-03 2.160
R-HSA-1250196 SHC1 events in ERBB2 signaling 7.104069e-03 2.148
R-HSA-390522 Striated Muscle Contraction 8.693074e-03 2.061
R-HSA-5673000 RAF activation 9.112961e-03 2.040
R-HSA-176034 Interactions of Tat with host cellular proteins 1.037957e-02 1.984
R-HSA-70326 Glucose metabolism 1.082820e-02 1.965
R-HSA-5675221 Negative regulation of MAPK pathway 1.278791e-02 1.893
R-HSA-68886 M Phase 1.302916e-02 1.885
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 1.328580e-02 1.877
R-HSA-187037 Signaling by NTRK1 (TRKA) 1.368056e-02 1.864
R-HSA-8854214 TBC/RABGAPs 1.379205e-02 1.860
R-HSA-190828 Gap junction trafficking 1.430659e-02 1.844
R-HSA-3928662 EPHB-mediated forward signaling 1.430659e-02 1.844
R-HSA-1266738 Developmental Biology 1.586243e-02 1.800
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 1.589934e-02 1.799
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 1.589934e-02 1.799
R-HSA-157858 Gap junction trafficking and regulation 1.700151e-02 1.770
R-HSA-416476 G alpha (q) signalling events 1.717603e-02 1.765
R-HSA-445355 Smooth Muscle Contraction 1.930050e-02 1.714
R-HSA-166520 Signaling by NTRKs 2.024130e-02 1.694
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 2.049636e-02 1.688
R-HSA-418597 G alpha (z) signalling events 2.049636e-02 1.688
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 2.110569e-02 1.676
R-HSA-5673001 RAF/MAP kinase cascade 2.259478e-02 1.646
R-HSA-8873719 RAB geranylgeranylation 2.361755e-02 1.627
R-HSA-1227986 Signaling by ERBB2 2.361755e-02 1.627
R-HSA-74713 IRS activation 2.405455e-02 1.619
R-HSA-9022535 Loss of phosphorylation of MECP2 at T308 2.405455e-02 1.619
R-HSA-450294 MAP kinase activation 2.426388e-02 1.615
R-HSA-5684996 MAPK1/MAPK3 signaling 2.427951e-02 1.615
R-HSA-109581 Apoptosis 2.494883e-02 1.603
R-HSA-9732724 IFNG signaling activates MAPKs 3.418882e-02 1.466
R-HSA-114516 Disinhibition of SNARE formation 3.418882e-02 1.466
R-HSA-390450 Folding of actin by CCT/TriC 4.421972e-02 1.354
R-HSA-2428933 SHC-related events triggered by IGF1R 5.414828e-02 1.266
R-HSA-69478 G2/M DNA replication checkpoint 3.082227e-02 1.511
R-HSA-187706 Signalling to p38 via RIT and RIN 2.744419e-02 1.562
R-HSA-170984 ARMS-mediated activation 4.088751e-02 1.388
R-HSA-2179392 EGFR Transactivation by Gastrin 4.421972e-02 1.354
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 4.421972e-02 1.354
R-HSA-9924644 Developmental Lineages of the Mammary Gland 3.183851e-02 1.497
R-HSA-430116 GP1b-IX-V activation signalling 4.088751e-02 1.388
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 5.414828e-02 1.266
R-HSA-9697154 Disorders of Nervous System Development 5.414828e-02 1.266
R-HSA-9005895 Pervasive developmental disorders 5.414828e-02 1.266
R-HSA-5607764 CLEC7A (Dectin-1) signaling 5.369295e-02 1.270
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 5.414828e-02 1.266
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 2.980560e-02 1.526
R-HSA-5617833 Cilium Assembly 3.642108e-02 1.439
R-HSA-9659379 Sensory processing of sound 3.708099e-02 1.431
R-HSA-74749 Signal attenuation 4.421972e-02 1.354
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 2.898751e-02 1.538
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 3.256796e-02 1.487
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 3.942277e-02 1.404
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 3.183851e-02 1.497
R-HSA-448424 Interleukin-17 signaling 3.039953e-02 1.517
R-HSA-2559583 Cellular Senescence 3.220429e-02 1.492
R-HSA-9013694 Signaling by NOTCH4 3.330400e-02 1.478
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 4.263049e-02 1.370
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 3.183851e-02 1.497
R-HSA-5357801 Programmed Cell Death 4.373092e-02 1.359
R-HSA-975871 MyD88 cascade initiated on plasma membrane 5.547685e-02 1.256
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 5.547685e-02 1.256
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 5.547685e-02 1.256
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 5.743524e-02 1.241
R-HSA-170968 Frs2-mediated activation 5.743524e-02 1.241
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 5.743524e-02 1.241
R-HSA-382551 Transport of small molecules 5.796117e-02 1.237
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 6.071097e-02 1.217
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 6.071097e-02 1.217
R-HSA-1433559 Regulation of KIT signaling 6.071097e-02 1.217
R-HSA-157118 Signaling by NOTCH 6.206230e-02 1.207
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 6.281691e-02 1.202
R-HSA-399954 Sema3A PAK dependent Axon repulsion 6.397553e-02 1.194
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 6.397553e-02 1.194
R-HSA-1295596 Spry regulation of FGF signaling 6.397553e-02 1.194
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 6.565059e-02 1.183
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 6.565059e-02 1.183
R-HSA-975155 MyD88 dependent cascade initiated on endosome 6.660464e-02 1.176
R-HSA-169893 Prolonged ERK activation events 6.722894e-02 1.172
R-HSA-5099900 WNT5A-dependent internalization of FZD4 6.722894e-02 1.172
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 6.756336e-02 1.170
R-HSA-166166 MyD88-independent TLR4 cascade 6.756336e-02 1.170
R-HSA-5663205 Infectious disease 6.930375e-02 1.159
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 7.046714e-02 1.152
R-HSA-9927020 Heme assimilation 7.047124e-02 1.152
R-HSA-399997 Acetylcholine regulates insulin secretion 7.047124e-02 1.152
R-HSA-9675151 Disorders of Developmental Biology 7.047124e-02 1.152
R-HSA-69620 Cell Cycle Checkpoints 7.268292e-02 1.139
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 7.341146e-02 1.134
R-HSA-9007101 Rab regulation of trafficking 7.639518e-02 1.117
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 7.692267e-02 1.114
R-HSA-9613829 Chaperone Mediated Autophagy 7.692267e-02 1.114
R-HSA-4419969 Depolymerization of the Nuclear Lamina 7.692267e-02 1.114
R-HSA-3928664 Ephrin signaling 7.692267e-02 1.114
R-HSA-156711 Polo-like kinase mediated events 7.692267e-02 1.114
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 7.840569e-02 1.106
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 7.840569e-02 1.106
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 8.013188e-02 1.096
R-HSA-1480926 O2/CO2 exchange in erythrocytes 8.013188e-02 1.096
R-HSA-1912420 Pre-NOTCH Processing in Golgi 8.013188e-02 1.096
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 8.145267e-02 1.089
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 8.145267e-02 1.089
R-HSA-76002 Platelet activation, signaling and aggregation 8.276410e-02 1.082
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 8.333013e-02 1.079
R-HSA-1280215 Cytokine Signaling in Immune system 8.434026e-02 1.074
R-HSA-8856688 Golgi-to-ER retrograde transport 9.399535e-02 1.027
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 9.601426e-02 1.018
R-HSA-912526 Interleukin receptor SHC signaling 9.601426e-02 1.018
R-HSA-3000170 Syndecan interactions 9.601426e-02 1.018
R-HSA-9932444 ATP-dependent chromatin remodelers 1.022915e-01 0.990
R-HSA-9932451 SWI/SNF chromatin remodelers 1.022915e-01 0.990
R-HSA-9664422 FCGR3A-mediated phagocytosis 1.037463e-01 0.984
R-HSA-9664407 Parasite infection 1.037463e-01 0.984
R-HSA-9664417 Leishmania phagocytosis 1.037463e-01 0.984
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 1.048466e-01 0.979
R-HSA-8856828 Clathrin-mediated endocytosis 1.081668e-01 0.966
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 1.085260e-01 0.964
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 1.085260e-01 0.964
R-HSA-389357 CD28 dependent PI3K/Akt signaling 1.085260e-01 0.964
R-HSA-167287 HIV elongation arrest and recovery 1.116272e-01 0.952
R-HSA-167290 Pausing and recovery of HIV elongation 1.116272e-01 0.952
R-HSA-77387 Insulin receptor recycling 1.116272e-01 0.952
R-HSA-5654732 Negative regulation of FGFR3 signaling 1.116272e-01 0.952
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 1.137628e-01 0.944
R-HSA-9615710 Late endosomal microautophagy 1.147179e-01 0.940
R-HSA-5654733 Negative regulation of FGFR4 signaling 1.147179e-01 0.940
R-HSA-1852241 Organelle biogenesis and maintenance 1.148264e-01 0.940
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.159497e-01 0.936
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 1.208676e-01 0.918
R-HSA-399719 Trafficking of AMPA receptors 1.208676e-01 0.918
R-HSA-9820960 Respiratory syncytial virus (RSV) attachment and entry 1.208676e-01 0.918
R-HSA-877300 Interferon gamma signaling 1.263296e-01 0.898
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 1.269753e-01 0.896
R-HSA-9022692 Regulation of MECP2 expression and activity 1.269753e-01 0.896
R-HSA-5654726 Negative regulation of FGFR1 signaling 1.269753e-01 0.896
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 1.269753e-01 0.896
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 1.269753e-01 0.896
R-HSA-5696394 DNA Damage Recognition in GG-NER 1.300135e-01 0.886
R-HSA-114508 Effects of PIP2 hydrolysis 1.300135e-01 0.886
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 1.330413e-01 0.876
R-HSA-5654727 Negative regulation of FGFR2 signaling 1.330413e-01 0.876
R-HSA-187687 Signalling to ERKs 1.360588e-01 0.866
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 1.420628e-01 0.848
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 1.480259e-01 0.830
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 1.509921e-01 0.821
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 1.509921e-01 0.821
R-HSA-167169 HIV Transcription Elongation 1.509921e-01 0.821
R-HSA-451927 Interleukin-2 family signaling 1.509921e-01 0.821
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 1.539482e-01 0.813
R-HSA-5218920 VEGFR2 mediated vascular permeability 1.539482e-01 0.813
R-HSA-5653656 Vesicle-mediated transport 1.606144e-01 0.794
R-HSA-168256 Immune System 1.618515e-01 0.791
R-HSA-1433557 Signaling by SCF-KIT 1.627560e-01 0.788
R-HSA-5654743 Signaling by FGFR4 1.627560e-01 0.788
R-HSA-168898 Toll-like Receptor Cascades 1.657707e-01 0.780
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 1.685777e-01 0.773
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 1.685777e-01 0.773
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 1.685777e-01 0.773
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 1.685777e-01 0.773
R-HSA-5654741 Signaling by FGFR3 1.685777e-01 0.773
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 1.714737e-01 0.766
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 1.768851e-01 0.752
R-HSA-389356 Co-stimulation by CD28 1.772359e-01 0.751
R-HSA-2514856 The phototransduction cascade 1.858055e-01 0.731
R-HSA-449147 Signaling by Interleukins 1.867271e-01 0.729
R-HSA-112382 Formation of RNA Pol II elongation complex 1.886425e-01 0.724
R-HSA-75955 RNA Polymerase II Transcription Elongation 1.914698e-01 0.718
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 1.914698e-01 0.718
R-HSA-9730414 MITF-M-regulated melanocyte development 1.944012e-01 0.711
R-HSA-5578775 Ion homeostasis 1.998937e-01 0.699
R-HSA-5654736 Signaling by FGFR1 1.998937e-01 0.699
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 1.998937e-01 0.699
R-HSA-2980766 Nuclear Envelope Breakdown 2.026825e-01 0.693
R-HSA-199991 Membrane Trafficking 2.030709e-01 0.692
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 2.109917e-01 0.676
R-HSA-2428928 IRS-related events triggered by IGF1R 2.137424e-01 0.670
R-HSA-9707616 Heme signaling 2.164838e-01 0.665
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 2.164838e-01 0.665
R-HSA-69615 G1/S DNA Damage Checkpoints 2.192158e-01 0.659
R-HSA-373755 Semaphorin interactions 2.192158e-01 0.659
R-HSA-2428924 IGF1R signaling cascade 2.219384e-01 0.654
R-HSA-74751 Insulin receptor signalling cascade 2.219384e-01 0.654
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 2.246517e-01 0.648
R-HSA-8939211 ESR-mediated signaling 2.249076e-01 0.648
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 2.296503e-01 0.639
R-HSA-6798695 Neutrophil degranulation 2.314917e-01 0.635
R-HSA-167172 Transcription of the HIV genome 2.327359e-01 0.633
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 2.407374e-01 0.618
R-HSA-9638482 Metal ion assimilation from the host 2.407374e-01 0.618
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 2.407374e-01 0.618
R-HSA-4086398 Ca2+ pathway 2.460261e-01 0.609
R-HSA-674695 RNA Polymerase II Pre-transcription Events 2.486568e-01 0.604
R-HSA-5689603 UCH proteinases 2.538914e-01 0.595
R-HSA-9734767 Developmental Cell Lineages 2.583541e-01 0.588
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 2.590900e-01 0.587
R-HSA-4086400 PCP/CE pathway 2.590900e-01 0.587
R-HSA-5654738 Signaling by FGFR2 2.642532e-01 0.578
R-HSA-9711123 Cellular response to chemical stress 2.648075e-01 0.577
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 2.719316e-01 0.566
R-HSA-9707564 Cytoprotection by HMOX1 2.719316e-01 0.566
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 2.744736e-01 0.561
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 2.795314e-01 0.554
R-HSA-141424 Amplification of signal from the kinetochores 2.795314e-01 0.554
R-HSA-1643685 Disease 2.819647e-01 0.550
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 2.820473e-01 0.550
R-HSA-390466 Chaperonin-mediated protein folding 2.845546e-01 0.546
R-HSA-2262752 Cellular responses to stress 2.935050e-01 0.532
R-HSA-8986944 Transcriptional Regulation by MECP2 2.944979e-01 0.531
R-HSA-74752 Signaling by Insulin receptor 2.994186e-01 0.524
R-HSA-391251 Protein folding 2.994186e-01 0.524
R-HSA-9837999 Mitochondrial protein degradation 3.043055e-01 0.517
R-HSA-2168880 Scavenging of heme from plasma 3.091590e-01 0.510
R-HSA-1280218 Adaptive Immune System 3.127986e-01 0.505
R-HSA-170834 Signaling by TGF-beta Receptor Complex 3.139792e-01 0.503
R-HSA-190236 Signaling by FGFR 3.163769e-01 0.500
R-HSA-3214847 HATs acetylate histones 3.187664e-01 0.497
R-HSA-69618 Mitotic Spindle Checkpoint 3.211476e-01 0.493
R-HSA-9009391 Extra-nuclear estrogen signaling 3.235207e-01 0.490
R-HSA-9842860 Regulation of endogenous retroelements 3.258857e-01 0.487
R-HSA-2559580 Oxidative Stress Induced Senescence 3.258857e-01 0.487
R-HSA-1483255 PI Metabolism 3.258857e-01 0.487
R-HSA-5696398 Nucleotide Excision Repair 3.352645e-01 0.475
R-HSA-2672351 Stimuli-sensing channels 3.422144e-01 0.466
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 3.445151e-01 0.463
R-HSA-1483249 Inositol phosphate metabolism 3.513700e-01 0.454
R-HSA-1912422 Pre-NOTCH Expression and Processing 3.536393e-01 0.451
R-HSA-2029485 Role of phospholipids in phagocytosis 3.626387e-01 0.441
R-HSA-68875 Mitotic Prophase 3.737151e-01 0.427
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 3.759075e-01 0.425
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 3.802699e-01 0.420
R-HSA-162909 Host Interactions of HIV factors 3.824398e-01 0.417
R-HSA-9006931 Signaling by Nuclear Receptors 3.858442e-01 0.414
R-HSA-69481 G2/M Checkpoints 3.910452e-01 0.408
R-HSA-199418 Negative regulation of the PI3K/AKT network 3.974218e-01 0.401
R-HSA-5576891 Cardiac conduction 4.016364e-01 0.396
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 4.058221e-01 0.392
R-HSA-913531 Interferon Signaling 4.116463e-01 0.385
R-HSA-9018519 Estrogen-dependent gene expression 4.141073e-01 0.383
R-HSA-3858494 Beta-catenin independent WNT signaling 4.141073e-01 0.383
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 4.161608e-01 0.381
R-HSA-162599 Late Phase of HIV Life Cycle 4.283342e-01 0.368
R-HSA-2187338 Visual phototransduction 4.382881e-01 0.358
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 4.441784e-01 0.352
R-HSA-9856651 MITF-M-dependent gene expression 4.441784e-01 0.352
R-HSA-9755511 KEAP1-NFE2L2 pathway 4.461284e-01 0.351
R-HSA-9612973 Autophagy 4.557778e-01 0.341
R-HSA-162587 HIV Life Cycle 4.576877e-01 0.339
R-HSA-9006936 Signaling by TGFB family members 4.633782e-01 0.334
R-HSA-2467813 Separation of Sister Chromatids 4.708744e-01 0.327
R-HSA-983712 Ion channel transport 5.171532e-01 0.286
R-HSA-9640148 Infection with Enterobacteria 5.404011e-01 0.267
R-HSA-68882 Mitotic Anaphase 5.625488e-01 0.250
R-HSA-2555396 Mitotic Metaphase and Anaphase 5.640900e-01 0.249
R-HSA-8953854 Metabolism of RNA 5.776330e-01 0.238
R-HSA-162906 HIV Infection 5.792121e-01 0.237
R-HSA-3247509 Chromatin modifying enzymes 5.894897e-01 0.230
R-HSA-4839726 Chromatin organization 6.106901e-01 0.214
R-HSA-5688426 Deubiquitination 6.188658e-01 0.208
R-HSA-388841 Regulation of T cell activation by CD28 family 6.202119e-01 0.207
R-HSA-1257604 PIP3 activates AKT signaling 6.692208e-01 0.174
R-HSA-1483257 Phospholipid metabolism 6.692208e-01 0.174
R-HSA-195721 Signaling by WNT 6.727223e-01 0.172
R-HSA-212165 Epigenetic regulation of gene expression 7.005202e-01 0.155
R-HSA-73894 DNA Repair 7.374556e-01 0.132
R-HSA-9824439 Bacterial Infection Pathways 7.649261e-01 0.116
R-HSA-556833 Metabolism of lipids 7.819489e-01 0.107
R-HSA-3700989 Transcriptional Regulation by TP53 8.202430e-01 0.086
R-HSA-9709957 Sensory Perception 8.233384e-01 0.084
R-HSA-9824446 Viral Infection Pathways 9.157765e-01 0.038
R-HSA-597592 Post-translational protein modification 9.405824e-01 0.027
R-HSA-74160 Gene expression (Transcription) 9.755282e-01 0.011
R-HSA-392499 Metabolism of proteins 9.773832e-01 0.010
R-HSA-212436 Generic Transcription Pathway 9.776616e-01 0.010
R-HSA-73857 RNA Polymerase II Transcription 9.859937e-01 0.006
R-HSA-1430728 Metabolism 9.864769e-01 0.006
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
MST4MST4 0.501 0.215 2 0.286
RSK3RSK3 0.491 0.066 -3 0.268
SGK3SGK3 0.491 0.108 -3 0.281
RSK2RSK2 0.487 0.048 -3 0.271
PLK4PLK4 0.487 0.116 2 0.078
DCAMKL2DCAMKL2 0.486 0.081 -3 0.324
PKN3PKN3 0.486 0.094 -3 0.303
MTORMTOR 0.486 0.150 1 0.511
CAMK2BCAMK2B 0.484 0.032 2 0.137
GRK7GRK7 0.483 0.083 1 0.466
TGFBR1TGFBR1 0.483 0.080 -2 0.730
CAMK2GCAMK2G 0.482 0.018 2 0.127
DCAMKL1DCAMKL1 0.482 0.088 -3 0.328
PKN2PKN2 0.482 0.069 -3 0.313
PKACGPKACG 0.481 0.068 -2 0.643
TGFBR2TGFBR2 0.480 0.087 -2 0.746
P90RSKP90RSK 0.480 0.032 -3 0.280
CAMK1BCAMK1B 0.480 0.019 -3 0.297
TSSK1TSSK1 0.479 0.097 -3 0.360
P70S6KBP70S6KB 0.479 0.034 -3 0.284
CAMK2DCAMK2D 0.479 0.059 -3 0.298
RSK4RSK4 0.478 0.031 -3 0.267
PLK3PLK3 0.478 0.045 2 0.098
COTCOT 0.478 -0.003 2 0.143
GCN2GCN2 0.478 0.038 2 0.164
NDR2NDR2 0.478 0.093 -3 0.316
PHKG1PHKG1 0.477 0.074 -3 0.320
NUAK2NUAK2 0.477 0.064 -3 0.318
NDR1NDR1 0.477 0.052 -3 0.314
PRP4PRP4 0.477 0.266 -3 0.680
NIM1NIM1 0.476 0.136 3 0.548
BCKDKBCKDK 0.476 0.049 -1 0.293
WNK1WNK1 0.476 0.040 -2 0.606
TBK1TBK1 0.476 0.044 1 0.507
CAMK4CAMK4 0.476 0.034 -3 0.302
PHKG2PHKG2 0.476 0.059 -3 0.316
PDHK1PDHK1 0.475 0.081 1 0.469
PKCDPKCD 0.475 0.036 2 0.111
ALK4ALK4 0.475 0.053 -2 0.726
MNK2MNK2 0.475 0.063 -2 0.614
AMPKA1AMPKA1 0.474 0.048 -3 0.337
SGK1SGK1 0.474 0.057 -3 0.198
ALK2ALK2 0.474 0.055 -2 0.734
LATS2LATS2 0.473 0.029 -5 0.520
P70S6KP70S6K 0.473 0.057 -3 0.222
ULK2ULK2 0.473 0.001 2 0.134
HUNKHUNK 0.473 0.008 2 0.147
PLK1PLK1 0.473 0.025 -2 0.682
BMPR2BMPR2 0.473 -0.010 -2 0.694
DSTYKDSTYK 0.472 -0.056 2 0.156
PDHK4PDHK4 0.472 0.015 1 0.463
ACVR2AACVR2A 0.472 0.044 -2 0.734
AKT2AKT2 0.472 0.033 -3 0.237
PRPKPRPK 0.472 -0.025 -1 0.300
MAPKAPK2MAPKAPK2 0.472 0.025 -3 0.262
DNAPKDNAPK 0.472 0.030 1 0.385
AKT1AKT1 0.471 0.048 -3 0.260
NLKNLK 0.471 0.017 1 0.359
TTBK2TTBK2 0.471 -0.051 2 0.145
PKCAPKCA 0.471 0.052 2 0.108
AURAAURA 0.470 0.045 -2 0.542
PKG2PKG2 0.470 0.045 -2 0.613
WNK3WNK3 0.470 -0.002 1 0.442
IKKEIKKE 0.470 -0.004 1 0.495
PKACAPKACA 0.470 0.037 -2 0.598
CAMK2ACAMK2A 0.470 -0.011 2 0.125
NIKNIK 0.470 0.001 -3 0.324
PKACBPKACB 0.469 0.041 -2 0.609
CDC7CDC7 0.469 0.023 1 0.316
NUAK1NUAK1 0.469 0.046 -3 0.292
NEK7NEK7 0.469 -0.011 -3 0.261
CLK3CLK3 0.469 -0.002 1 0.284
MNK1MNK1 0.469 0.035 -2 0.630
ACVR2BACVR2B 0.468 0.016 -2 0.734
GRK6GRK6 0.468 -0.053 1 0.442
AKT3AKT3 0.468 0.043 -3 0.210
PAK6PAK6 0.468 0.015 -2 0.532
MARK4MARK4 0.468 0.062 4 0.385
PLK2PLK2 0.468 0.014 -3 0.267
CLK1CLK1 0.468 0.008 -3 0.275
NEK2NEK2 0.467 0.012 2 0.177
PRKD1PRKD1 0.467 0.024 -3 0.304
MAPKAPK3MAPKAPK3 0.467 -0.013 -3 0.286
AMPKA2AMPKA2 0.467 0.029 -3 0.325
PRKXPRKX 0.467 0.034 -3 0.284
ULK1ULK1 0.467 -0.048 -3 0.273
TTBK1TTBK1 0.466 -0.040 2 0.104
LATS1LATS1 0.466 -0.006 -3 0.311
CAMLCKCAMLCK 0.466 -0.012 -2 0.657
PRKD2PRKD2 0.466 0.011 -3 0.313
MOSMOS 0.466 -0.034 1 0.338
PIM1PIM1 0.466 -0.011 -3 0.281
MSK1MSK1 0.466 -0.007 -3 0.238
SIKSIK 0.465 0.048 -3 0.268
NEK9NEK9 0.465 -0.005 2 0.198
PKN1PKN1 0.465 0.050 -3 0.246
MST3MST3 0.465 0.089 2 0.198
CDK2CDK2 0.465 0.048 1 0.298
NEK6NEK6 0.465 0.006 -2 0.685
AURCAURC 0.465 0.054 -2 0.578
CLK2CLK2 0.465 0.017 -3 0.285
PKCGPKCG 0.465 0.010 2 0.095
PIM3PIM3 0.465 -0.032 -3 0.301
PKCHPKCH 0.465 -0.002 2 0.093
BMPR1BBMPR1B 0.464 0.020 1 0.286
MARK2MARK2 0.464 0.053 4 0.396
DAPK2DAPK2 0.464 -0.022 -3 0.303
RAF1RAF1 0.464 -0.042 1 0.438
MELKMELK 0.463 0.016 -3 0.317
PRKD3PRKD3 0.463 -0.011 -3 0.254
QSKQSK 0.463 0.055 4 0.367
CLK4CLK4 0.463 -0.005 -3 0.279
BMPR1ABMPR1A 0.463 0.035 1 0.294
AURBAURB 0.462 0.036 -2 0.570
CDKL1CDKL1 0.462 -0.022 -3 0.248
SKMLCKSKMLCK 0.462 -0.014 -2 0.645
PKCTPKCT 0.462 0.020 2 0.105
CRIKCRIK 0.462 0.078 -3 0.238
QIKQIK 0.462 0.037 -3 0.289
ATRATR 0.462 -0.052 1 0.338
PDK1PDK1 0.462 0.142 1 0.577
TSSK2TSSK2 0.461 -0.008 -5 0.541
PAK1PAK1 0.461 -0.018 -2 0.590
ZAKZAK 0.461 -0.002 1 0.526
PKRPKR 0.461 0.054 1 0.336
GRK4GRK4 0.461 -0.062 -2 0.629
PAK3PAK3 0.461 -0.020 -2 0.593
MEK1MEK1 0.460 -0.053 2 0.152
CAMK1GCAMK1G 0.460 -0.015 -3 0.252
PAK5PAK5 0.460 0.013 -2 0.492
MASTLMASTL 0.460 -0.032 -2 0.569
RIPK3RIPK3 0.460 -0.014 3 0.540
DLKDLK 0.460 -0.101 1 0.473
TLK2TLK2 0.459 0.025 1 0.344
WNK4WNK4 0.459 0.024 -2 0.574
HRIHRI 0.459 -0.011 -2 0.713
MSK2MSK2 0.459 -0.030 -3 0.219
TAO3TAO3 0.459 0.069 1 0.442
GRK1GRK1 0.459 -0.051 -2 0.566
IKKBIKKB 0.459 -0.065 -2 0.520
PIM2PIM2 0.459 0.007 -3 0.258
FAM20CFAM20C 0.458 -0.023 2 0.066
PKCIPKCI 0.458 0.021 2 0.128
PKCBPKCB 0.458 -0.016 2 0.107
RIPK1RIPK1 0.458 -0.014 1 0.434
MLK1MLK1 0.458 -0.074 2 0.152
MARK1MARK1 0.457 0.024 4 0.371
PKCEPKCE 0.457 0.014 2 0.102
GRK5GRK5 0.457 -0.084 -3 0.266
MARK3MARK3 0.457 0.033 4 0.375
MEKK1MEKK1 0.457 0.007 1 0.443
CHK1CHK1 0.457 -0.015 -3 0.334
YSK4YSK4 0.457 -0.039 1 0.467
ANKRD3ANKRD3 0.457 -0.072 1 0.459
MAP3K15MAP3K15 0.456 0.099 1 0.530
EEF2KEEF2K 0.456 0.049 3 0.697
IKKAIKKA 0.456 -0.024 -2 0.503
SRPK3SRPK3 0.456 -0.014 -3 0.204
ICKICK 0.456 -0.023 -3 0.270
ATMATM 0.456 -0.054 1 0.307
MRCKAMRCKA 0.456 0.021 -3 0.273
TAO2TAO2 0.455 0.041 2 0.152
CAMK1DCAMK1D 0.455 -0.019 -3 0.249
PAK2PAK2 0.455 -0.030 -2 0.572
CDK3CDK3 0.455 0.041 1 0.172
PAK4PAK4 0.454 -0.003 -2 0.502
PERKPERK 0.454 -0.031 -2 0.706
YSK1YSK1 0.454 0.096 2 0.206
CHAK2CHAK2 0.454 -0.077 -1 0.220
SMMLCKSMMLCK 0.454 -0.031 -3 0.269
SRPK2SRPK2 0.454 -0.021 -3 0.203
PKG1PKG1 0.453 0.024 -2 0.566
CDK5CDK5 0.453 0.023 1 0.211
MAPKAPK5MAPKAPK5 0.453 -0.045 -3 0.211
VRK2VRK2 0.453 -0.026 1 0.413
DRAK1DRAK1 0.453 -0.036 1 0.472
NEK11NEK11 0.453 0.024 1 0.506
MYLK4MYLK4 0.452 -0.037 -2 0.632
CDK8CDK8 0.452 -0.002 1 0.251
GSK3AGSK3A 0.452 0.011 4 0.114
CHK2CHK2 0.452 -0.015 -3 0.225
CAMK1ACAMK1A 0.452 -0.004 -3 0.226
BRSK2BRSK2 0.452 -0.017 -3 0.311
JNK2JNK2 0.452 -0.005 1 0.219
MEKK3MEKK3 0.452 -0.060 1 0.437
BRSK1BRSK1 0.452 -0.028 -3 0.295
MRCKBMRCKB 0.452 0.010 -3 0.270
SRPK1SRPK1 0.452 -0.026 -3 0.245
IRE1IRE1 0.451 -0.038 1 0.307
NEK3NEK3 0.451 0.110 1 0.463
CDK1CDK1 0.451 0.001 1 0.201
IRE2IRE2 0.451 -0.048 2 0.089
CDKL5CDKL5 0.451 -0.036 -3 0.251
CDK12CDK12 0.451 0.029 1 0.218
CK2A2CK2A2 0.451 0.002 1 0.236
SNRKSNRK 0.451 -0.066 2 0.067
GSK3BGSK3B 0.451 -0.022 4 0.105
SSTKSSTK 0.450 -0.013 4 0.368
ERK7ERK7 0.450 -0.021 2 0.069
PKCZPKCZ 0.450 -0.022 2 0.132
TLK1TLK1 0.449 -0.068 -2 0.720
KISKIS 0.449 0.010 1 0.237
MEKK2MEKK2 0.449 -0.017 2 0.151
ERK5ERK5 0.449 -0.067 1 0.268
CDK13CDK13 0.448 0.012 1 0.221
HIPK4HIPK4 0.448 -0.003 1 0.257
TNIKTNIK 0.448 0.059 3 0.661
MLK4MLK4 0.448 -0.090 2 0.106
MINKMINK 0.448 0.063 1 0.413
HGKHGK 0.448 0.055 3 0.653
CDK19CDK19 0.447 -0.000 1 0.223
P38GP38G 0.447 -0.002 1 0.175
KHS2KHS2 0.447 0.080 1 0.392
BRAFBRAF 0.447 -0.083 -4 0.345
MEKK6MEKK6 0.447 0.034 1 0.411
MEK2MEK2 0.447 -0.010 2 0.170
HPK1HPK1 0.447 0.044 1 0.394
MLK2MLK2 0.447 -0.086 2 0.164
HIPK1HIPK1 0.447 0.006 1 0.244
JNK3JNK3 0.446 -0.027 1 0.255
GCKGCK 0.446 0.034 1 0.389
MEK5MEK5 0.446 -0.074 2 0.155
LOKLOK 0.446 0.004 -2 0.583
P38AP38A 0.446 0.003 1 0.230
KHS1KHS1 0.445 0.069 1 0.404
YANK3YANK3 0.445 -0.031 2 0.041
CDK18CDK18 0.445 0.009 1 0.183
CDK9CDK9 0.445 0.007 1 0.236
NEK5NEK5 0.445 -0.041 1 0.390
DMPK1DMPK1 0.444 0.013 -3 0.286
PASKPASK 0.444 -0.068 -3 0.286
CHAK1CHAK1 0.444 -0.111 2 0.158
CK1A2CK1A2 0.444 -0.051 -3 0.097
DAPK3DAPK3 0.443 -0.034 -3 0.297
SMG1SMG1 0.443 -0.071 1 0.306
IRAK4IRAK4 0.443 -0.064 1 0.353
CDK17CDK17 0.443 -0.009 1 0.177
CDK10CDK10 0.443 -0.005 1 0.199
MLK3MLK3 0.442 -0.091 2 0.117
DAPK1DAPK1 0.442 -0.037 -3 0.279
NEK1NEK1 0.442 0.041 1 0.409
ROCK2ROCK2 0.442 0.002 -3 0.308
CDK7CDK7 0.442 -0.019 1 0.219
GRK2GRK2 0.442 -0.081 -2 0.549
TAO1TAO1 0.441 0.050 1 0.462
CDK16CDK16 0.441 0.004 1 0.183
CK1ECK1E 0.441 -0.058 -3 0.127
GAKGAK 0.441 -0.033 1 0.321
CK2A1CK2A1 0.441 -0.013 1 0.235
IRAK1IRAK1 0.441 -0.106 -1 0.214
MPSK1MPSK1 0.441 0.023 1 0.267
CDK14CDK14 0.441 -0.011 1 0.222
RIPK2RIPK2 0.440 -0.072 1 0.517
STK33STK33 0.439 -0.065 2 0.079
NEK4NEK4 0.439 -0.027 1 0.383
DYRK1ADYRK1A 0.439 -0.027 1 0.279
P38BP38B 0.439 -0.018 1 0.211
GRK3GRK3 0.439 -0.063 -2 0.525
MST1MST1 0.438 -0.036 1 0.412
NEK8NEK8 0.438 -0.088 2 0.144
DYRK2DYRK2 0.438 -0.029 1 0.229
ROCK1ROCK1 0.438 -0.002 -3 0.291
HIPK2HIPK2 0.437 -0.005 1 0.173
ASK1ASK1 0.437 0.025 1 0.554
CK1DCK1D 0.436 -0.060 -3 0.096
DYRK3DYRK3 0.436 -0.016 1 0.247
SBKSBK 0.436 -0.035 -3 0.189
CK1G1CK1G1 0.436 -0.048 -3 0.109
MST2MST2 0.436 -0.054 1 0.400
LKB1LKB1 0.436 -0.006 -3 0.370
HIPK3HIPK3 0.435 -0.027 1 0.267
ERK2ERK2 0.435 -0.054 1 0.240
CDK6CDK6 0.434 -0.010 1 0.210
ERK1ERK1 0.434 -0.029 1 0.207
LRRK2LRRK2 0.433 -0.049 2 0.165
HASPINHASPIN 0.433 -0.025 -1 0.213
JNK1JNK1 0.433 -0.035 1 0.234
P38DP38D 0.432 -0.012 1 0.155
CAMKK1CAMKK1 0.431 -0.132 -2 0.546
CAMKK2CAMKK2 0.431 -0.077 -2 0.545
TAK1TAK1 0.431 -0.112 1 0.425
OSR1OSR1 0.431 -0.030 2 0.190
SLKSLK 0.431 -0.070 -2 0.524
DYRK1BDYRK1B 0.430 -0.032 1 0.197
DYRK4DYRK4 0.429 -0.042 1 0.196
CDK4CDK4 0.429 -0.022 1 0.208
MYO3BMYO3B 0.429 0.037 2 0.185
MYO3AMYO3A 0.428 0.003 1 0.362
VRK1VRK1 0.427 -0.110 2 0.132
PBKPBK 0.427 -0.025 1 0.253
PINK1PINK1 0.426 -0.155 1 0.282
MAKMAK 0.426 -0.008 -2 0.454
MOKMOK 0.423 -0.019 1 0.194
STLK3STLK3 0.420 -0.069 1 0.458
YANK2YANK2 0.420 -0.045 2 0.029
BIKEBIKE 0.420 -0.033 1 0.241
ALPHAK3ALPHAK3 0.420 -0.083 -1 0.240
TTKTTK 0.419 -0.067 -2 0.713
BUB1BUB1 0.417 -0.040 -5 0.499
AAK1AAK1 0.417 0.001 1 0.163
BMPR2_TYRBMPR2_TYR 0.414 -0.011 -1 0.344
NEK10_TYRNEK10_TYR 0.414 0.083 1 0.487
PDHK3_TYRPDHK3_TYR 0.413 -0.015 4 0.342
JAK1JAK1 0.413 0.066 1 0.538
DDR1DDR1 0.411 -0.017 4 0.334
TYK2TYK2 0.411 0.022 1 0.483
PINK1_TYRPINK1_TYR 0.411 -0.042 1 0.444
MAP2K7_TYRMAP2K7_TYR 0.411 -0.005 2 0.152
PKMYT1_TYRPKMYT1_TYR 0.409 0.087 3 0.606
CK1G3CK1G3 0.409 -0.076 -3 0.045
MAP2K4_TYRMAP2K4_TYR 0.409 0.003 -1 0.330
MST1RMST1R 0.409 -0.002 3 0.560
EGFREGFR 0.408 -0.005 1 0.585
FGFR2FGFR2 0.408 -0.053 3 0.580
JAK3JAK3 0.407 -0.028 1 0.539
FLT3FLT3 0.406 -0.033 3 0.549
JAK2JAK2 0.405 0.003 1 0.502
EPHA6EPHA6 0.405 -0.080 -1 0.240
CK1ACK1A 0.405 -0.080 -3 0.063
RETRET 0.404 -0.071 1 0.483
TESK1_TYRTESK1_TYR 0.404 -0.059 3 0.638
LIMK2_TYRLIMK2_TYR 0.404 0.008 -3 0.350
MAP2K6_TYRMAP2K6_TYR 0.403 -0.093 -1 0.324
PDHK4_TYRPDHK4_TYR 0.403 -0.072 2 0.153
PDGFRAPDGFRA 0.402 -0.035 3 0.556
FGFR1FGFR1 0.402 -0.043 3 0.533
CSF1RCSF1R 0.402 -0.046 3 0.549
TNNI3K_TYRTNNI3K_TYR 0.402 0.029 1 0.395
FGFR3FGFR3 0.401 -0.064 3 0.571
PDGFRBPDGFRB 0.401 -0.066 3 0.557
ERBB2ERBB2 0.401 -0.048 1 0.564
FLT1FLT1 0.400 -0.066 -1 0.258
FLT4FLT4 0.400 -0.064 3 0.534
KDRKDR 0.400 -0.054 3 0.536
PDHK1_TYRPDHK1_TYR 0.400 -0.116 -1 0.297
CK1G2CK1G2 0.399 -0.069 -3 0.082
ROS1ROS1 0.399 -0.055 3 0.520
KITKIT 0.398 -0.071 3 0.555
LIMK1_TYRLIMK1_TYR 0.398 -0.058 2 0.156
MUSKMUSK 0.396 -0.019 1 0.543
NTRK2NTRK2 0.395 -0.078 3 0.521
INSRRINSRR 0.395 -0.110 3 0.538
FGFR4FGFR4 0.394 -0.059 -1 0.197
NTRK1NTRK1 0.393 -0.101 -1 0.229
TNK1TNK1 0.393 -0.041 3 0.519
METMET 0.392 -0.072 3 0.527
EPHA4EPHA4 0.392 -0.112 2 0.094
YES1YES1 0.392 -0.092 -1 0.233
WEE1_TYRWEE1_TYR 0.392 -0.061 -1 0.220
TYRO3TYRO3 0.391 -0.134 3 0.549
HCKHCK 0.391 -0.097 -1 0.250
TEKTEK 0.391 -0.114 3 0.508
AXLAXL 0.389 -0.110 3 0.523
PTK2PTK2 0.389 -0.061 -1 0.277
ERBB4ERBB4 0.389 -0.031 1 0.507
DDR2DDR2 0.389 -0.060 3 0.547
MERTKMERTK 0.389 -0.111 3 0.514
NTRK3NTRK3 0.388 -0.081 -1 0.201
LCKLCK 0.388 -0.084 -1 0.252
FRKFRK 0.387 -0.089 -1 0.237
FERFER 0.387 -0.149 1 0.377
INSRINSR 0.387 -0.101 3 0.509
BTKBTK 0.387 -0.140 -1 0.209
EPHB4EPHB4 0.386 -0.165 -1 0.218
ITKITK 0.386 -0.104 -1 0.243
FYNFYN 0.386 -0.084 -1 0.260
EPHA3EPHA3 0.386 -0.119 2 0.083
SRMSSRMS 0.386 -0.147 1 0.384
SYKSYK 0.385 -0.066 -1 0.249
ABL2ABL2 0.385 -0.106 -1 0.218
FGRFGR 0.385 -0.121 1 0.364
TECTEC 0.385 -0.124 -1 0.185
ALKALK 0.384 -0.114 3 0.496
BLKBLK 0.383 -0.098 -1 0.252
EPHB1EPHB1 0.383 -0.167 1 0.401
TNK2TNK2 0.383 -0.116 3 0.523
IGF1RIGF1R 0.382 -0.087 3 0.460
PTK6PTK6 0.382 -0.137 -1 0.183
EPHB2EPHB2 0.382 -0.152 -1 0.206
TXKTXK 0.382 -0.120 1 0.330
EPHA7EPHA7 0.382 -0.126 2 0.083
EPHA1EPHA1 0.382 -0.127 3 0.508
ABL1ABL1 0.381 -0.116 -1 0.214
PTK2BPTK2B 0.381 -0.098 -1 0.183
LTKLTK 0.381 -0.128 3 0.511
SRCSRC 0.380 -0.090 -1 0.237
EPHA8EPHA8 0.380 -0.107 -1 0.218
BMXBMX 0.380 -0.119 -1 0.200
EPHB3EPHB3 0.379 -0.164 -1 0.201
CSKCSK 0.378 -0.117 2 0.098
LYNLYN 0.377 -0.114 3 0.487
EPHA5EPHA5 0.377 -0.144 2 0.066
ZAP70ZAP70 0.377 -0.034 -1 0.242
EPHA2EPHA2 0.376 -0.114 -1 0.206
MATKMATK 0.374 -0.121 -1 0.180
FESFES 0.370 -0.097 -1 0.177