Motif 700 (n=65)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A8MTJ3 | GNAT3 | S47 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction (PubMed:38600377, PubMed:38776963). Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs such as TAS2R14 act as bitter sensors (PubMed:38600377, PubMed:38776963). Also functions as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. {ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:17724330, ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}. |
| O43309 | ZSCAN12 | S399 | ochoa | Zinc finger and SCAN domain-containing protein 12 (Zinc finger protein 305) (Zinc finger protein 96) | May be involved in transcriptional regulation. |
| O60765 | ZNF354A | S311 | ochoa | Zinc finger protein 354A (Transcription factor 17) (TCF-17) (Zinc finger protein eZNF) | None |
| O95125 | ZNF202 | S466 | ochoa | Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10) | Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease. |
| O95409 | ZIC2 | S406 | ochoa | Zinc finger protein ZIC 2 (Zinc finger protein of the cerebellum 2) | Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. |
| P04049 | RAF1 | S359 | psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04899 | GNAI2 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P05141 | SLC25A5 | S42 | ochoa | ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed] | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P51881, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:31883789}. |
| P08047 | SP1 | S641 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08754 | GNAI3 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
| P09471 | GNAO1 | S47 | ochoa | Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:29925951, PubMed:33408414). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase (By similarity). Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). {ECO:0000250|UniProtKB:P18872, ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:33408414}. |
| P11488 | GNAT1 | S43 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) | Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). {ECO:0000250|UniProtKB:P04695, ECO:0000269|PubMed:22190596}. |
| P12235 | SLC25A4 | S42 | ochoa | ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4) | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:21586654, PubMed:27693233). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31883789). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:21586654, ECO:0000269|PubMed:27693233, ECO:0000269|PubMed:31883789}. |
| P12236 | SLC25A6 | S42 | ochoa | ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed] | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:15033708). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:15033708}. |
| P15056 | BRAF | S467 | psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P17028 | ZNF24 | S292 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P17098 | ZNF8 | S354 | ochoa | Zinc finger protein 8 (Zinc finger protein HF.18) | Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. {ECO:0000250|UniProtKB:Q8BGV5}. |
| P17612 | PRKACA | S54 | ochoa | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}. |
| P19087 | GNAT2 | S47 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. |
| P22694 | PRKACB | S54 | ochoa | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}. |
| P27816 | MAP4 | S358 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28698 | MZF1 | S453 | psp | Myeloid zinc finger 1 (MZF-1) (Zinc finger and SCAN domain-containing protein 6) (Zinc finger protein 42) | Binds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development. {ECO:0000269|PubMed:15541732, ECO:0000269|PubMed:17851584}. |
| P38405 | GNAL | S56 | ochoa | Guanine nucleotide-binding protein G(olf) subunit alpha (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein, olfactory type) | Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs) (By similarity). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (By similarity). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (By similarity). {ECO:0000250|UniProtKB:P38406, ECO:0000250|UniProtKB:Q8CGK7}. |
| P49711 | CTCF | S450 | ochoa | Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) | Chromatin binding factor that binds to DNA sequence specific sites and regulates the 3D structure of chromatin (PubMed:18347100, PubMed:18654629, PubMed:19322193). Binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures, such as the nuclear lamina (PubMed:18347100, PubMed:18654629, PubMed:19322193). Defines the boundaries between active and heterochromatic DNA via binding to chromatin insulators, thereby preventing interaction between promoter and nearby enhancers and silencers (PubMed:18347100, PubMed:18654629, PubMed:19322193). Plays a critical role in the epigenetic regulation (PubMed:16949368). Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus (PubMed:16107875, PubMed:16815976, PubMed:17827499). On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2 (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory (By similarity). Regulates asynchronous replication of IGF2/H19 (By similarity). Plays a critical role in gene silencing over considerable distances in the genome (By similarity). Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones (PubMed:18413740). Inversely, binding to target sites is prevented by CpG methylation (PubMed:18413740). Plays an important role in chromatin remodeling (PubMed:18413740). Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (PubMed:12191639). Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription (PubMed:12191639). When bound to chromatin, it provides an anchor point for nucleosomes positioning (PubMed:12191639). Seems to be essential for homologous X-chromosome pairing (By similarity). May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation (PubMed:11743158). May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation (PubMed:11743158). Involved in sister chromatid cohesion (PubMed:12191639). Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites (PubMed:18550811). Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640). Acts as a transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene (PubMed:18413740, PubMed:8649389, PubMed:9591631). Also binds to the PLK and PIM1 promoters (PubMed:12191639). Acts as a transcriptional activator of APP (PubMed:9407128). Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression (PubMed:18347100, PubMed:19322193). Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription (By similarity). Seems to act as tumor suppressor (PubMed:12191639). {ECO:0000250|UniProtKB:Q61164, ECO:0000269|PubMed:11743158, ECO:0000269|PubMed:16107875, ECO:0000269|PubMed:16815976, ECO:0000269|PubMed:16949368, ECO:0000269|PubMed:17827499, ECO:0000269|PubMed:18347100, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18550811, ECO:0000269|PubMed:18654629, ECO:0000269|PubMed:19322193, ECO:0000269|PubMed:26321640, ECO:0000269|PubMed:8649389, ECO:0000269|PubMed:9407128, ECO:0000269|PubMed:9591631, ECO:0000303|PubMed:12191639}. |
| P50148 | GNAQ | S53 | psp | Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:37991948). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:37991948). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:37991948). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:37991948). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:37991948). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNAQ activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:37991948). Required for platelet activation (By similarity). Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity (By similarity). Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNA11, required for heart development (By similarity). {ECO:0000250|UniProtKB:P21279, ECO:0000269|PubMed:27852822, ECO:0000269|PubMed:37991948}. |
| P51812 | RPS6KA3 | S78 | ochoa | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| P52737 | ZNF136 | S405 | ochoa | Zinc finger protein 136 | May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain. |
| P63096 | GNAI1 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883, PubMed:38918398). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:18434541, PubMed:8774883). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:18434541, PubMed:8774883). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:18434541, PubMed:8774883). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:8119955). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). {ECO:0000250|UniProtKB:P10824, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38552625, ECO:0000269|PubMed:38918398, ECO:0000269|PubMed:8119955, ECO:0000269|PubMed:8774883}. |
| P68104 | EEF1A1 | S21 | ochoa|psp | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| Q05639 | EEF1A2 | S21 | ochoa|psp | Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}. |
| Q05655 | PRKCD | S359 | psp | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q13043 | STK4 | S40 | psp | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13118 | KLF10 | S384 | psp | Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}. |
| Q13422 | IKZF1 | S214 | psp | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q14586 | ZNF267 | S229 | ochoa | Zinc finger protein 267 (Zinc finger protein HZF2) | May be involved in transcriptional regulation. |
| Q14592 | ZNF460 | S489 | ochoa | Zinc finger protein 460 (Zinc finger protein 272) (Zinc finger protein HZF8) | May be involved in transcriptional regulation. |
| Q15418 | RPS6KA1 | S72 | ochoa | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| Q15915 | ZIC1 | S375 | ochoa | Zinc finger protein ZIC 1 (Zinc finger protein 201) (Zinc finger protein of the cerebellum 1) | Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). {ECO:0000250|UniProtKB:P46684}. |
| Q5HY98 | ZNF766 | S144 | ochoa | Zinc finger protein 766 | May be involved in transcriptional regulation. |
| Q5JWF2 | GNAS | S697 | ochoa | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas) | Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. {ECO:0000250|UniProtKB:Q6R0H7}. |
| Q5VTE0 | EEF1A1P5 | S21 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q5VV52 | ZNF691 | S184 | ochoa | Zinc finger protein 691 | May be involved in transcriptional regulation. |
| Q68EA5 | ZNF57 | S153 | ochoa | Zinc finger protein 57 (Zinc finger protein 424) | May be involved in transcriptional regulation. |
| Q6PDB4 | ZNF880 | S421 | ochoa | Zinc finger protein 880 | None |
| Q6U7Q0 | ZNF322 | S224 | psp | Zinc finger protein 322 (Zinc finger protein 322A) (Zinc finger protein 388) (Zinc finger protein 489) | Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZ89, ECO:0000269|PubMed:15555580}. |
| Q8NAF0 | ZNF579 | Y57 | ochoa | Zinc finger protein 579 | May be involved in transcriptional regulation. |
| Q8TF68 | ZNF384 | S269 | ochoa | Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein) | Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). {ECO:0000250}. |
| Q8WUU4 | ZNF296 | S244 | ochoa | Zinc finger protein 296 (ZFP296) (Zinc finger protein 342) | May be a transcriptional corepressor with KLF4. {ECO:0000250|UniProtKB:E9Q6W4}. |
| Q96K58 | ZNF668 | S585 | ochoa | Zinc finger protein 668 | May be involved in transcriptional regulation. May play a role in DNA repair process. {ECO:0000269|PubMed:34313816}. |
| Q96LW1 | ZNF354B | S311 | ochoa | Zinc finger protein 354B | Transcriptional repressor that binds DNA upon activation by RAS proteins signal transduction to initiate transcriptional silencing through the recruitment of additional DNA-binding proteins, multisubunit complexes and chromatin-modifying activities to establish a platform for DNMT1 recruitment. {ECO:0000250|UniProtKB:Q9QXT9}. |
| Q96MX3 | ZNF48 | S316 | ochoa | Zinc finger protein 48 (Zinc finger protein 553) | May be involved in transcriptional regulation. |
| Q9HAZ2 | PRDM16 | S379 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9HAZ2 | PRDM16 | S436 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9P289 | STK26 | S34 | ochoa | Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) | Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}. |
| Q9UK32 | RPS6KA6 | S83 | ochoa | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q9UKN5 | PRDM4 | S603 | ochoa | PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) | May function as a transcription factor involved in cell differentiation. |
| O00506 | STK25 | S30 | Sugiyama | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}. |
| O75582 | RPS6KA5 | S436 | Sugiyama | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| Q9BR84 | ZNF559 | S198 | Sugiyama | Zinc finger protein 559 | May be involved in transcriptional regulation. |
| Q9H5H4 | ZNF768 | S330 | Sugiyama | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| P22612 | PRKACG | S54 | Sugiyama | cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus. |
| Q13188 | STK3 | S37 | Sugiyama | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}. |
| Q9Y6E0 | STK24 | S46 | Sugiyama | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
| Q7L7X3 | TAOK1 | S38 | Sugiyama | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q9UL54 | TAOK2 | S38 | Sugiyama | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-112040 | G-protein mediated events | 5.206946e-14 | 13.283 |
| R-HSA-9634597 | GPER1 signaling | 5.198064e-12 | 11.284 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 3.200551e-12 | 11.495 |
| R-HSA-111885 | Opioid Signalling | 4.992118e-12 | 11.302 |
| R-HSA-418594 | G alpha (i) signalling events | 6.427242e-10 | 9.192 |
| R-HSA-418597 | G alpha (z) signalling events | 5.258176e-10 | 9.279 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.513797e-10 | 9.259 |
| R-HSA-422356 | Regulation of insulin secretion | 1.729060e-09 | 8.762 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 2.995724e-08 | 7.523 |
| R-HSA-163685 | Integration of energy metabolism | 3.131412e-08 | 7.504 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.088996e-08 | 7.388 |
| R-HSA-388396 | GPCR downstream signalling | 6.105568e-08 | 7.214 |
| R-HSA-164378 | PKA activation in glucagon signalling | 7.679902e-08 | 7.115 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 2.158438e-07 | 6.666 |
| R-HSA-418555 | G alpha (s) signalling events | 1.929913e-07 | 6.714 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 2.105703e-07 | 6.677 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 2.105703e-07 | 6.677 |
| R-HSA-372790 | Signaling by GPCR | 2.499675e-07 | 6.602 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.830057e-07 | 6.548 |
| R-HSA-112043 | PLC beta mediated events | 7.590007e-07 | 6.120 |
| R-HSA-180897 | Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabiliza... | 9.024358e-07 | 6.045 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 1.152009e-06 | 5.939 |
| R-HSA-392518 | Signal amplification | 1.298890e-06 | 5.886 |
| R-HSA-111933 | Calmodulin induced events | 1.636777e-06 | 5.786 |
| R-HSA-111997 | CaM pathway | 1.636777e-06 | 5.786 |
| R-HSA-112316 | Neuronal System | 1.731937e-06 | 5.761 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 3.055650e-06 | 5.515 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.396098e-06 | 5.469 |
| R-HSA-991365 | Activation of GABAB receptors | 3.396098e-06 | 5.469 |
| R-HSA-977444 | GABA B receptor activation | 3.396098e-06 | 5.469 |
| R-HSA-111996 | Ca-dependent events | 3.396098e-06 | 5.469 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 4.497833e-06 | 5.347 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.497833e-06 | 5.347 |
| R-HSA-392517 | Rap1 signalling | 4.681347e-06 | 5.330 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.007878e-06 | 5.300 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 6.404594e-06 | 5.194 |
| R-HSA-199920 | CREB phosphorylation | 1.011563e-05 | 4.995 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 7.127367e-06 | 5.147 |
| R-HSA-9658195 | Leishmania infection | 8.191726e-06 | 5.087 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.191726e-06 | 5.087 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.254932e-05 | 4.901 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.384500e-05 | 4.859 |
| R-HSA-977443 | GABA receptor activation | 1.484731e-05 | 4.828 |
| R-HSA-445717 | Aquaporin-mediated transport | 1.591651e-05 | 4.798 |
| R-HSA-444257 | RSK activation | 1.835087e-05 | 4.736 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.304583e-05 | 4.637 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.626295e-05 | 4.581 |
| R-HSA-194138 | Signaling by VEGF | 4.128983e-05 | 4.384 |
| R-HSA-8853659 | RET signaling | 4.524900e-05 | 4.344 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.223365e-05 | 4.282 |
| R-HSA-109582 | Hemostasis | 5.350736e-05 | 4.272 |
| R-HSA-162582 | Signal Transduction | 6.511485e-05 | 4.186 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 6.644629e-05 | 4.178 |
| R-HSA-8963896 | HDL assembly | 7.862305e-05 | 4.104 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 1.071618e-04 | 3.970 |
| R-HSA-437239 | Recycling pathway of L1 | 1.163214e-04 | 3.934 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.483400e-04 | 3.829 |
| R-HSA-163615 | PKA activation | 1.614215e-04 | 3.792 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.828190e-04 | 3.738 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.309553e-04 | 3.636 |
| R-HSA-198753 | ERK/MAPK targets | 2.309553e-04 | 3.636 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.165794e-04 | 3.664 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 3.502798e-04 | 3.456 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 4.617726e-04 | 3.336 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.131253e-04 | 3.290 |
| R-HSA-180024 | DARPP-32 events | 5.474129e-04 | 3.262 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 5.474129e-04 | 3.262 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 7.477506e-04 | 3.126 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 6.164123e-04 | 3.210 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 6.939056e-04 | 3.159 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.768709e-04 | 3.169 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 8.371000e-04 | 3.077 |
| R-HSA-422475 | Axon guidance | 9.414398e-04 | 3.026 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 9.575937e-04 | 3.019 |
| R-HSA-163560 | Triglyceride catabolism | 9.895191e-04 | 3.005 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.155347e-03 | 2.937 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.155347e-03 | 2.937 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.275769e-03 | 2.894 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.370993e-03 | 2.863 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.436475e-03 | 2.843 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.436475e-03 | 2.843 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.436475e-03 | 2.843 |
| R-HSA-9675108 | Nervous system development | 1.459842e-03 | 2.836 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.652404e-03 | 2.782 |
| R-HSA-75153 | Apoptotic execution phase | 1.892229e-03 | 2.723 |
| R-HSA-373760 | L1CAM interactions | 2.824358e-03 | 2.549 |
| R-HSA-9823739 | Formation of the anterior neural plate | 3.368320e-03 | 2.473 |
| R-HSA-8979227 | Triglyceride metabolism | 3.467850e-03 | 2.460 |
| R-HSA-450294 | MAP kinase activation | 3.763781e-03 | 2.424 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 4.091133e-03 | 2.388 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 5.297596e-03 | 2.276 |
| R-HSA-2028269 | Signaling by Hippo | 4.477137e-03 | 2.349 |
| R-HSA-448424 | Interleukin-17 signaling | 5.283949e-03 | 2.277 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.959805e-03 | 2.402 |
| R-HSA-9834899 | Specification of the neural plate border | 5.297596e-03 | 2.276 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.664889e-03 | 2.247 |
| R-HSA-1266738 | Developmental Biology | 5.330810e-03 | 2.273 |
| R-HSA-4086398 | Ca2+ pathway | 5.861385e-03 | 2.232 |
| R-HSA-8939211 | ESR-mediated signaling | 5.979860e-03 | 2.223 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 6.061927e-03 | 2.217 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.070225e-03 | 2.217 |
| R-HSA-166520 | Signaling by NTRKs | 6.660971e-03 | 2.176 |
| R-HSA-9758941 | Gastrulation | 6.800307e-03 | 2.167 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 8.662576e-03 | 2.062 |
| R-HSA-416476 | G alpha (q) signalling events | 8.986905e-03 | 2.046 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 9.204023e-03 | 2.036 |
| R-HSA-420092 | Glucagon-type ligand receptors | 1.091638e-02 | 1.962 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.095223e-02 | 1.960 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 1.095223e-02 | 1.960 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 1.151604e-02 | 1.939 |
| R-HSA-9837999 | Mitochondrial protein degradation | 1.153616e-02 | 1.938 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.307352e-02 | 1.884 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.307352e-02 | 1.884 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.307352e-02 | 1.884 |
| R-HSA-70171 | Glycolysis | 1.371970e-02 | 1.863 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.421073e-02 | 1.847 |
| R-HSA-5673000 | RAF activation | 1.472485e-02 | 1.832 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.576621e-02 | 1.802 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.681374e-02 | 1.774 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.685055e-02 | 1.773 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.722109e-02 | 1.764 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.759617e-02 | 1.755 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.759617e-02 | 1.755 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.770082e-02 | 1.752 |
| R-HSA-168277 | Influenza Virus Induced Apoptosis | 1.772806e-02 | 1.751 |
| R-HSA-5663205 | Infectious disease | 1.841104e-02 | 1.735 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.874879e-02 | 1.727 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.902104e-02 | 1.721 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.902104e-02 | 1.721 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.994253e-02 | 1.700 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.055666e-02 | 1.687 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.055666e-02 | 1.687 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.055666e-02 | 1.687 |
| R-HSA-70326 | Glucose metabolism | 2.117744e-02 | 1.674 |
| R-HSA-212436 | Generic Transcription Pathway | 2.137696e-02 | 1.670 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 2.647551e-02 | 1.577 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 3.082038e-02 | 1.511 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 4.374059e-02 | 1.359 |
| R-HSA-114516 | Disinhibition of SNARE formation | 4.374059e-02 | 1.359 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.461272e-02 | 1.609 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.461272e-02 | 1.609 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.461272e-02 | 1.609 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.261845e-02 | 1.370 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.461272e-02 | 1.609 |
| R-HSA-2514856 | The phototransduction cascade | 2.896665e-02 | 1.538 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 3.514613e-02 | 1.454 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 2.461272e-02 | 1.609 |
| R-HSA-1268020 | Mitochondrial protein import | 3.952172e-02 | 1.403 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 2.559168e-02 | 1.592 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.149269e-02 | 1.502 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.202362e-02 | 1.657 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.202362e-02 | 1.657 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.332727e-02 | 1.632 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.332727e-02 | 1.632 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.319848e-02 | 1.635 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.862241e-02 | 1.413 |
| R-HSA-382551 | Transport of small molecules | 3.428995e-02 | 1.465 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.864505e-02 | 1.543 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.750751e-02 | 1.426 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.960166e-02 | 1.402 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.421929e-02 | 1.616 |
| R-HSA-109581 | Apoptosis | 4.714214e-02 | 1.327 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.797370e-02 | 1.319 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.907292e-02 | 1.309 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.018129e-02 | 1.299 |
| R-HSA-170984 | ARMS-mediated activation | 5.225955e-02 | 1.282 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 5.225955e-02 | 1.282 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 5.225955e-02 | 1.282 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 5.225955e-02 | 1.282 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 5.649092e-02 | 1.248 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 5.649092e-02 | 1.248 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.651047e-02 | 1.248 |
| R-HSA-2559583 | Cellular Senescence | 6.005620e-02 | 1.221 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.174637e-02 | 1.209 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.537777e-02 | 1.185 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.821607e-02 | 1.166 |
| R-HSA-9005895 | Pervasive developmental disorders | 6.907357e-02 | 1.161 |
| R-HSA-9697154 | Disorders of Nervous System Development | 6.907357e-02 | 1.161 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 6.907357e-02 | 1.161 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 7.284867e-02 | 1.138 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 7.323090e-02 | 1.135 |
| R-HSA-170968 | Frs2-mediated activation | 7.323090e-02 | 1.135 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 7.323090e-02 | 1.135 |
| R-HSA-1433559 | Regulation of KIT signaling | 7.736993e-02 | 1.111 |
| R-HSA-5357801 | Programmed Cell Death | 8.011104e-02 | 1.096 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 8.149072e-02 | 1.089 |
| R-HSA-8876725 | Protein methylation | 8.149072e-02 | 1.089 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 8.149072e-02 | 1.089 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 8.149072e-02 | 1.089 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 8.559336e-02 | 1.068 |
| R-HSA-2485179 | Activation of the phototransduction cascade | 8.559336e-02 | 1.068 |
| R-HSA-169893 | Prolonged ERK activation events | 8.559336e-02 | 1.068 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 8.559336e-02 | 1.068 |
| R-HSA-166187 | Mitochondrial Uncoupling | 8.559336e-02 | 1.068 |
| R-HSA-9675151 | Disorders of Developmental Biology | 8.967794e-02 | 1.047 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 9.126520e-02 | 1.040 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 9.779318e-02 | 1.010 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 9.779318e-02 | 1.010 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 9.779318e-02 | 1.010 |
| R-HSA-3928664 | Ephrin signaling | 9.779318e-02 | 1.010 |
| R-HSA-418346 | Platelet homeostasis | 9.814328e-02 | 1.008 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 9.814328e-02 | 1.008 |
| R-HSA-162906 | HIV Infection | 9.906027e-02 | 1.004 |
| R-HSA-74160 | Gene expression (Transcription) | 1.024094e-01 | 0.990 |
| R-HSA-1181150 | Signaling by NODAL | 1.058371e-01 | 0.975 |
| R-HSA-202040 | G-protein activation | 1.098325e-01 | 0.959 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 1.217133e-01 | 0.915 |
| R-HSA-3000170 | Syndecan interactions | 1.217133e-01 | 0.915 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 1.256387e-01 | 0.901 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 1.256387e-01 | 0.901 |
| R-HSA-9839394 | TGFBR3 expression | 1.295468e-01 | 0.888 |
| R-HSA-9843745 | Adipogenesis | 1.405556e-01 | 0.852 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.411681e-01 | 0.850 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.450078e-01 | 0.839 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.450078e-01 | 0.839 |
| R-HSA-168249 | Innate Immune System | 1.473557e-01 | 0.832 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 1.488305e-01 | 0.827 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.488305e-01 | 0.827 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.526364e-01 | 0.816 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.601978e-01 | 0.795 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.601978e-01 | 0.795 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.601978e-01 | 0.795 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.601978e-01 | 0.795 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 1.639536e-01 | 0.785 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.676928e-01 | 0.775 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.676928e-01 | 0.775 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.676928e-01 | 0.775 |
| R-HSA-2187338 | Visual phototransduction | 1.685460e-01 | 0.773 |
| R-HSA-195721 | Signaling by WNT | 1.703824e-01 | 0.769 |
| R-HSA-187687 | Signalling to ERKs | 1.714155e-01 | 0.766 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.714155e-01 | 0.766 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.714155e-01 | 0.766 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.748938e-01 | 0.757 |
| R-HSA-3371511 | HSF1 activation | 1.751217e-01 | 0.757 |
| R-HSA-9609507 | Protein localization | 1.780825e-01 | 0.749 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.788117e-01 | 0.748 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 1.861427e-01 | 0.730 |
| R-HSA-877300 | Interferon gamma signaling | 1.877025e-01 | 0.727 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.934093e-01 | 0.714 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.934093e-01 | 0.714 |
| R-HSA-1643685 | Disease | 1.961523e-01 | 0.707 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 2.006118e-01 | 0.698 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.006118e-01 | 0.698 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.041893e-01 | 0.690 |
| R-HSA-5654743 | Signaling by FGFR4 | 2.041893e-01 | 0.690 |
| R-HSA-5654741 | Signaling by FGFR3 | 2.112969e-01 | 0.675 |
| R-HSA-9839373 | Signaling by TGFBR3 | 2.148272e-01 | 0.668 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.153201e-01 | 0.667 |
| R-HSA-68877 | Mitotic Prometaphase | 2.449498e-01 | 0.611 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.459066e-01 | 0.609 |
| R-HSA-5578775 | Ion homeostasis | 2.492841e-01 | 0.603 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.492841e-01 | 0.603 |
| R-HSA-5654736 | Signaling by FGFR1 | 2.492841e-01 | 0.603 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.526467e-01 | 0.597 |
| R-HSA-68886 | M Phase | 2.691952e-01 | 0.570 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 2.692380e-01 | 0.570 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.725124e-01 | 0.565 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.725124e-01 | 0.565 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.725124e-01 | 0.565 |
| R-HSA-373755 | Semaphorin interactions | 2.725124e-01 | 0.565 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.797178e-01 | 0.553 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.822490e-01 | 0.549 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 2.874256e-01 | 0.541 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.950316e-01 | 0.530 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.044709e-01 | 0.516 |
| R-HSA-380287 | Centrosome maturation | 3.106945e-01 | 0.508 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.106945e-01 | 0.508 |
| R-HSA-4086400 | PCP/CE pathway | 3.199270e-01 | 0.495 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.229773e-01 | 0.491 |
| R-HSA-5654738 | Signaling by FGFR2 | 3.260141e-01 | 0.487 |
| R-HSA-72766 | Translation | 3.266130e-01 | 0.486 |
| R-HSA-449147 | Signaling by Interleukins | 3.272355e-01 | 0.485 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.380276e-01 | 0.471 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.439550e-01 | 0.463 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.439550e-01 | 0.463 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 3.468990e-01 | 0.460 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.498300e-01 | 0.456 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.527480e-01 | 0.453 |
| R-HSA-156902 | Peptide chain elongation | 3.527480e-01 | 0.453 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 3.585080e-01 | 0.446 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.585453e-01 | 0.445 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.614247e-01 | 0.442 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.650668e-01 | 0.438 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.671454e-01 | 0.435 |
| R-HSA-391251 | Protein folding | 3.671454e-01 | 0.435 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.697351e-01 | 0.432 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.812270e-01 | 0.419 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.840060e-01 | 0.416 |
| R-HSA-190236 | Signaling by FGFR | 3.867727e-01 | 0.413 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.895271e-01 | 0.409 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.922693e-01 | 0.406 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.030805e-01 | 0.395 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 4.057994e-01 | 0.392 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.057994e-01 | 0.392 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.140189e-01 | 0.383 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.164092e-01 | 0.380 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.190323e-01 | 0.378 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 4.396029e-01 | 0.357 |
| R-HSA-2980736 | Peptide hormone metabolism | 4.446323e-01 | 0.352 |
| R-HSA-68875 | Mitotic Prophase | 4.520930e-01 | 0.345 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.545579e-01 | 0.342 |
| R-HSA-3371556 | Cellular response to heat stress | 4.545579e-01 | 0.342 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.545579e-01 | 0.342 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.552654e-01 | 0.342 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 4.594549e-01 | 0.338 |
| R-HSA-9717189 | Sensory perception of taste | 4.832971e-01 | 0.316 |
| R-HSA-5576891 | Cardiac conduction | 4.832971e-01 | 0.316 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.879396e-01 | 0.312 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.906231e-01 | 0.309 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.971014e-01 | 0.304 |
| R-HSA-2262752 | Cellular responses to stress | 4.993020e-01 | 0.302 |
| R-HSA-73887 | Death Receptor Signaling | 5.384597e-01 | 0.269 |
| R-HSA-1989781 | PPARA activates gene expression | 5.405410e-01 | 0.267 |
| R-HSA-913531 | Interferon Signaling | 5.420963e-01 | 0.266 |
| R-HSA-9612973 | Autophagy | 5.426130e-01 | 0.266 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.446758e-01 | 0.264 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.508094e-01 | 0.259 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.588609e-01 | 0.253 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.783723e-01 | 0.238 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.783723e-01 | 0.238 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.802760e-01 | 0.236 |
| R-HSA-168255 | Influenza Infection | 5.896680e-01 | 0.229 |
| R-HSA-9824446 | Viral Infection Pathways | 5.896963e-01 | 0.229 |
| R-HSA-69275 | G2/M Transition | 6.024696e-01 | 0.220 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.060543e-01 | 0.217 |
| R-HSA-983712 | Ion channel transport | 6.078346e-01 | 0.216 |
| R-HSA-5617833 | Cilium Assembly | 6.096071e-01 | 0.215 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.200770e-01 | 0.208 |
| R-HSA-6798695 | Neutrophil degranulation | 6.341873e-01 | 0.198 |
| R-HSA-1640170 | Cell Cycle | 6.383352e-01 | 0.195 |
| R-HSA-397014 | Muscle contraction | 6.482615e-01 | 0.188 |
| R-HSA-68882 | Mitotic Anaphase | 6.545875e-01 | 0.184 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.561514e-01 | 0.183 |
| R-HSA-418990 | Adherens junctions interactions | 6.577083e-01 | 0.182 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.816937e-01 | 0.166 |
| R-HSA-157118 | Signaling by NOTCH | 6.902543e-01 | 0.161 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.959596e-01 | 0.157 |
| R-HSA-4839726 | Chromatin organization | 7.026712e-01 | 0.153 |
| R-HSA-421270 | Cell-cell junction organization | 7.053631e-01 | 0.152 |
| R-HSA-1280218 | Adaptive Immune System | 7.106194e-01 | 0.148 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.145969e-01 | 0.146 |
| R-HSA-9679506 | SARS-CoV Infections | 7.334404e-01 | 0.135 |
| R-HSA-446728 | Cell junction organization | 7.394357e-01 | 0.131 |
| R-HSA-500792 | GPCR ligand binding | 7.621986e-01 | 0.118 |
| R-HSA-1500931 | Cell-Cell communication | 7.808993e-01 | 0.107 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.848656e-01 | 0.105 |
| R-HSA-8957322 | Metabolism of steroids | 7.887610e-01 | 0.103 |
| R-HSA-1474244 | Extracellular matrix organization | 7.954114e-01 | 0.099 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.045551e-01 | 0.094 |
| R-HSA-9709957 | Sensory Perception | 8.233433e-01 | 0.084 |
| R-HSA-392499 | Metabolism of proteins | 8.687397e-01 | 0.061 |
| R-HSA-168256 | Immune System | 8.970859e-01 | 0.047 |
| R-HSA-8953854 | Metabolism of RNA | 9.012332e-01 | 0.045 |
| R-HSA-556833 | Metabolism of lipids | 9.147703e-01 | 0.039 |
| R-HSA-1430728 | Metabolism | 9.663149e-01 | 0.015 |
| R-HSA-381753 | Olfactory Signaling Pathway | 9.830821e-01 | 0.007 |
| R-HSA-597592 | Post-translational protein modification | 9.996413e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MST4 |
0.668 | 0.188 | 2 | 0.440 |
PKN2 |
0.667 | 0.177 | -3 | 0.657 |
MNK2 |
0.664 | 0.179 | -2 | 0.744 |
AURC |
0.663 | 0.152 | -2 | 0.678 |
COT |
0.663 | 0.057 | 2 | 0.440 |
PKACG |
0.663 | 0.135 | -2 | 0.748 |
RSK3 |
0.663 | 0.102 | -3 | 0.615 |
WNK1 |
0.662 | 0.170 | -2 | 0.743 |
PKCD |
0.660 | 0.149 | 2 | 0.368 |
TSSK1 |
0.659 | 0.157 | -3 | 0.698 |
SGK3 |
0.659 | 0.183 | -3 | 0.614 |
PKCA |
0.659 | 0.144 | 2 | 0.329 |
PKN3 |
0.659 | 0.141 | -3 | 0.657 |
PKCG |
0.658 | 0.124 | 2 | 0.329 |
MTOR |
0.658 | 0.112 | 1 | 0.705 |
CLK3 |
0.657 | 0.103 | 1 | 0.676 |
MNK1 |
0.657 | 0.158 | -2 | 0.733 |
PLK4 |
0.657 | 0.153 | 2 | 0.443 |
RSK2 |
0.657 | 0.086 | -3 | 0.613 |
NIM1 |
0.656 | 0.151 | 3 | 0.601 |
P90RSK |
0.656 | 0.079 | -3 | 0.629 |
NLK |
0.656 | 0.102 | 1 | 0.697 |
PKCI |
0.656 | 0.166 | 2 | 0.369 |
IRE1 |
0.656 | 0.126 | 1 | 0.600 |
PKCZ |
0.655 | 0.149 | 2 | 0.382 |
PHKG1 |
0.655 | 0.102 | -3 | 0.664 |
PKCH |
0.655 | 0.126 | 2 | 0.345 |
NUAK1 |
0.655 | 0.093 | -3 | 0.614 |
PKCB |
0.654 | 0.106 | 2 | 0.320 |
AURB |
0.654 | 0.136 | -2 | 0.686 |
RIPK3 |
0.654 | 0.123 | 3 | 0.634 |
DCAMKL1 |
0.654 | 0.155 | -3 | 0.628 |
NUAK2 |
0.654 | 0.077 | -3 | 0.650 |
NDR1 |
0.653 | 0.052 | -3 | 0.655 |
NDR2 |
0.653 | 0.028 | -3 | 0.657 |
PKCT |
0.653 | 0.144 | 2 | 0.353 |
DCAMKL2 |
0.652 | 0.141 | -3 | 0.632 |
PHKG2 |
0.652 | 0.121 | -3 | 0.617 |
SRPK1 |
0.652 | 0.097 | -3 | 0.614 |
PKG2 |
0.652 | 0.124 | -2 | 0.698 |
MELK |
0.652 | 0.124 | -3 | 0.650 |
PKCE |
0.652 | 0.159 | 2 | 0.328 |
SKMLCK |
0.652 | 0.120 | -2 | 0.751 |
CDK5 |
0.651 | 0.118 | 1 | 0.580 |
PIM3 |
0.651 | 0.045 | -3 | 0.666 |
CDKL1 |
0.651 | 0.071 | -3 | 0.634 |
PKN1 |
0.651 | 0.154 | -3 | 0.582 |
LATS2 |
0.651 | 0.043 | -5 | 0.593 |
WNK3 |
0.651 | 0.090 | 1 | 0.650 |
ULK2 |
0.651 | 0.018 | 2 | 0.437 |
CAMK1B |
0.650 | 0.060 | -3 | 0.659 |
PRKD2 |
0.650 | 0.057 | -3 | 0.633 |
CAMK4 |
0.650 | 0.097 | -3 | 0.637 |
TGFBR2 |
0.650 | 0.029 | -2 | 0.643 |
CHAK2 |
0.650 | 0.103 | -1 | 0.714 |
CLK1 |
0.650 | 0.119 | -3 | 0.585 |
CDC7 |
0.648 | -0.000 | 1 | 0.675 |
AMPKA1 |
0.648 | 0.079 | -3 | 0.676 |
DAPK2 |
0.647 | 0.134 | -3 | 0.668 |
AKT1 |
0.647 | 0.143 | -3 | 0.572 |
CDKL5 |
0.647 | 0.042 | -3 | 0.639 |
GCN2 |
0.647 | -0.067 | 2 | 0.402 |
IRE2 |
0.647 | 0.085 | 2 | 0.456 |
SRPK2 |
0.646 | 0.081 | -3 | 0.554 |
CDK2 |
0.646 | 0.119 | 1 | 0.631 |
PAK3 |
0.646 | 0.080 | -2 | 0.716 |
AKT2 |
0.645 | 0.106 | -3 | 0.553 |
NIK |
0.645 | 0.094 | -3 | 0.676 |
RIPK1 |
0.644 | 0.086 | 1 | 0.682 |
TSSK2 |
0.644 | 0.071 | -5 | 0.684 |
CAMLCK |
0.644 | 0.082 | -2 | 0.744 |
QIK |
0.644 | 0.069 | -3 | 0.640 |
CDK14 |
0.644 | 0.100 | 1 | 0.568 |
PRKD1 |
0.643 | 0.012 | -3 | 0.685 |
CDK10 |
0.643 | 0.101 | 1 | 0.560 |
CDK3 |
0.643 | 0.124 | 1 | 0.507 |
HUNK |
0.643 | -0.007 | 2 | 0.444 |
PDHK4 |
0.643 | -0.063 | 1 | 0.699 |
IRAK4 |
0.643 | 0.150 | 1 | 0.604 |
PRKD3 |
0.643 | 0.052 | -3 | 0.591 |
PAK6 |
0.643 | 0.074 | -2 | 0.657 |
CLK4 |
0.643 | 0.098 | -3 | 0.605 |
PIM1 |
0.642 | 0.051 | -3 | 0.629 |
CAMK1G |
0.642 | 0.070 | -3 | 0.601 |
TBK1 |
0.642 | -0.026 | 1 | 0.612 |
CDK12 |
0.642 | 0.088 | 1 | 0.535 |
PRPK |
0.642 | -0.091 | -1 | 0.606 |
CDK13 |
0.642 | 0.075 | 1 | 0.556 |
P70S6KB |
0.641 | 0.042 | -3 | 0.626 |
SNRK |
0.641 | 0.025 | 2 | 0.458 |
ICK |
0.641 | 0.051 | -3 | 0.661 |
PAK1 |
0.641 | 0.065 | -2 | 0.715 |
AMPKA2 |
0.641 | 0.052 | -3 | 0.653 |
PKACB |
0.641 | 0.090 | -2 | 0.713 |
WNK4 |
0.641 | 0.162 | -2 | 0.737 |
RSK4 |
0.640 | 0.065 | -3 | 0.592 |
CDK18 |
0.640 | 0.063 | 1 | 0.529 |
MASTL |
0.640 | -0.010 | -2 | 0.663 |
AURA |
0.639 | 0.093 | -2 | 0.662 |
MAPKAPK3 |
0.639 | 0.006 | -3 | 0.642 |
AKT3 |
0.639 | 0.120 | -3 | 0.523 |
ULK1 |
0.639 | -0.040 | -3 | 0.599 |
MARK4 |
0.639 | 0.039 | 4 | 0.588 |
CHAK1 |
0.638 | 0.058 | 2 | 0.408 |
NEK6 |
0.638 | -0.027 | -2 | 0.696 |
CAMK2D |
0.638 | 0.010 | -3 | 0.673 |
MSK2 |
0.638 | 0.038 | -3 | 0.607 |
BMPR2 |
0.638 | -0.075 | -2 | 0.694 |
MSK1 |
0.637 | 0.067 | -3 | 0.612 |
NEK7 |
0.637 | -0.072 | -3 | 0.603 |
MYLK4 |
0.637 | 0.070 | -2 | 0.728 |
CDK1 |
0.637 | 0.077 | 1 | 0.563 |
PAK2 |
0.637 | 0.067 | -2 | 0.707 |
KIS |
0.637 | 0.006 | 1 | 0.571 |
MOS |
0.637 | -0.067 | 1 | 0.697 |
CLK2 |
0.637 | 0.095 | -3 | 0.614 |
PKACA |
0.636 | 0.092 | -2 | 0.679 |
RAF1 |
0.636 | -0.090 | 1 | 0.665 |
NEK2 |
0.636 | 0.049 | 2 | 0.414 |
DRAK1 |
0.636 | 0.085 | 1 | 0.805 |
MLK1 |
0.635 | -0.048 | 2 | 0.399 |
PDHK1 |
0.635 | -0.077 | 1 | 0.653 |
MST3 |
0.635 | 0.143 | 2 | 0.404 |
PIM2 |
0.635 | 0.069 | -3 | 0.593 |
SRPK3 |
0.635 | 0.060 | -3 | 0.579 |
CAMK2G |
0.635 | -0.080 | 2 | 0.370 |
PRKX |
0.635 | 0.081 | -3 | 0.543 |
DSTYK |
0.634 | -0.108 | 2 | 0.380 |
QSK |
0.633 | 0.038 | 4 | 0.582 |
CDK9 |
0.633 | 0.049 | 1 | 0.557 |
CDK17 |
0.633 | 0.050 | 1 | 0.497 |
PLK1 |
0.633 | 0.041 | -2 | 0.647 |
ATR |
0.632 | -0.074 | 1 | 0.611 |
NEK9 |
0.632 | -0.041 | 2 | 0.436 |
SMMLCK |
0.632 | 0.107 | -3 | 0.638 |
PAK5 |
0.632 | 0.070 | -2 | 0.635 |
LATS1 |
0.632 | 0.048 | -3 | 0.651 |
HIPK4 |
0.632 | -0.000 | 1 | 0.600 |
MLK3 |
0.631 | -0.003 | 2 | 0.320 |
ANKRD3 |
0.630 | -0.003 | 1 | 0.696 |
CDK6 |
0.630 | 0.098 | 1 | 0.544 |
ERK5 |
0.630 | -0.056 | 1 | 0.630 |
SSTK |
0.630 | 0.053 | 4 | 0.600 |
IKKE |
0.629 | -0.108 | 1 | 0.590 |
DYRK1A |
0.629 | 0.059 | 1 | 0.612 |
CDK8 |
0.629 | 0.009 | 1 | 0.554 |
PRP4 |
0.629 | 0.171 | -3 | 0.772 |
SIK |
0.628 | 0.010 | -3 | 0.594 |
CDK19 |
0.628 | 0.018 | 1 | 0.519 |
PKR |
0.628 | 0.080 | 1 | 0.632 |
SGK1 |
0.628 | 0.103 | -3 | 0.507 |
CDK7 |
0.628 | 0.006 | 1 | 0.570 |
BRSK2 |
0.627 | -0.031 | -3 | 0.651 |
CDK16 |
0.627 | 0.062 | 1 | 0.510 |
P70S6K |
0.627 | 0.041 | -3 | 0.565 |
CHK2 |
0.627 | 0.066 | -3 | 0.519 |
HIPK3 |
0.626 | 0.062 | 1 | 0.559 |
PKG1 |
0.626 | 0.089 | -2 | 0.651 |
PAK4 |
0.626 | 0.053 | -2 | 0.642 |
P38A |
0.625 | 0.044 | 1 | 0.584 |
IKKB |
0.625 | -0.181 | -2 | 0.545 |
MAPKAPK2 |
0.625 | -0.017 | -3 | 0.603 |
MARK3 |
0.625 | 0.016 | 4 | 0.551 |
GRK5 |
0.625 | -0.142 | -3 | 0.626 |
HIPK1 |
0.624 | 0.060 | 1 | 0.558 |
MEK1 |
0.624 | -0.034 | 2 | 0.427 |
MARK2 |
0.624 | 0.011 | 4 | 0.531 |
VRK2 |
0.624 | 0.071 | 1 | 0.678 |
ALK4 |
0.624 | -0.004 | -2 | 0.645 |
MLK4 |
0.623 | -0.042 | 2 | 0.334 |
MLK2 |
0.623 | -0.083 | 2 | 0.395 |
MRCKA |
0.623 | 0.109 | -3 | 0.593 |
BCKDK |
0.623 | -0.125 | -1 | 0.544 |
DYRK3 |
0.623 | 0.078 | 1 | 0.535 |
TTBK2 |
0.623 | -0.123 | 2 | 0.366 |
ZAK |
0.622 | 0.024 | 1 | 0.661 |
MRCKB |
0.622 | 0.097 | -3 | 0.587 |
CAMK2B |
0.622 | -0.046 | 2 | 0.321 |
IRAK1 |
0.622 | -0.018 | -1 | 0.541 |
PDK1 |
0.622 | 0.162 | 1 | 0.743 |
DYRK2 |
0.621 | 0.025 | 1 | 0.524 |
CAMK1D |
0.621 | 0.032 | -3 | 0.562 |
CHK1 |
0.621 | -0.027 | -3 | 0.653 |
DLK |
0.620 | -0.132 | 1 | 0.704 |
HRI |
0.620 | -0.027 | -2 | 0.675 |
BRSK1 |
0.620 | -0.049 | -3 | 0.633 |
ERK2 |
0.620 | 0.017 | 1 | 0.587 |
CAMK2A |
0.619 | -0.050 | 2 | 0.305 |
MAPKAPK5 |
0.619 | -0.043 | -3 | 0.604 |
HIPK2 |
0.619 | 0.039 | 1 | 0.479 |
MPSK1 |
0.619 | 0.058 | 1 | 0.629 |
CAMK1A |
0.618 | 0.058 | -3 | 0.526 |
MARK1 |
0.618 | -0.009 | 4 | 0.566 |
NEK11 |
0.618 | 0.081 | 1 | 0.710 |
CDK4 |
0.618 | 0.064 | 1 | 0.518 |
MEKK6 |
0.618 | 0.108 | 1 | 0.621 |
YSK4 |
0.618 | -0.072 | 1 | 0.636 |
P38G |
0.618 | 0.029 | 1 | 0.486 |
DAPK1 |
0.617 | 0.093 | -3 | 0.622 |
DAPK3 |
0.617 | 0.085 | -3 | 0.632 |
ERK1 |
0.617 | 0.018 | 1 | 0.527 |
NEK5 |
0.616 | 0.036 | 1 | 0.649 |
ROCK2 |
0.616 | 0.109 | -3 | 0.633 |
TGFBR1 |
0.616 | -0.035 | -2 | 0.625 |
STK33 |
0.616 | -0.001 | 2 | 0.321 |
HASPIN |
0.616 | 0.120 | -1 | 0.676 |
JNK2 |
0.615 | 0.022 | 1 | 0.539 |
BMPR1B |
0.615 | -0.004 | 1 | 0.681 |
MEK5 |
0.615 | -0.041 | 2 | 0.427 |
MAP3K15 |
0.615 | 0.118 | 1 | 0.658 |
TNIK |
0.614 | 0.147 | 3 | 0.753 |
TAO3 |
0.614 | 0.043 | 1 | 0.665 |
MEKK2 |
0.614 | 0.013 | 2 | 0.408 |
IKKA |
0.614 | -0.143 | -2 | 0.509 |
HGK |
0.614 | 0.121 | 3 | 0.769 |
DMPK1 |
0.614 | 0.114 | -3 | 0.588 |
ACVR2A |
0.614 | -0.035 | -2 | 0.608 |
TAO2 |
0.614 | 0.062 | 2 | 0.413 |
GRK6 |
0.614 | -0.141 | 1 | 0.705 |
CK1E |
0.614 | -0.039 | -3 | 0.400 |
GRK7 |
0.614 | -0.034 | 1 | 0.680 |
NEK3 |
0.614 | 0.107 | 1 | 0.606 |
ERK7 |
0.613 | -0.015 | 2 | 0.214 |
DYRK1B |
0.613 | 0.031 | 1 | 0.532 |
PINK1 |
0.613 | -0.087 | 1 | 0.675 |
KHS2 |
0.613 | 0.140 | 1 | 0.624 |
MAK |
0.612 | 0.065 | -2 | 0.511 |
MINK |
0.612 | 0.119 | 1 | 0.619 |
YSK1 |
0.612 | 0.110 | 2 | 0.409 |
HPK1 |
0.611 | 0.085 | 1 | 0.644 |
SMG1 |
0.611 | -0.092 | 1 | 0.543 |
MEKK1 |
0.611 | -0.053 | 1 | 0.631 |
EEF2K |
0.611 | 0.099 | 3 | 0.781 |
MEKK3 |
0.611 | -0.070 | 1 | 0.657 |
LOK |
0.611 | 0.046 | -2 | 0.662 |
NEK8 |
0.611 | -0.003 | 2 | 0.439 |
PLK3 |
0.610 | -0.073 | 2 | 0.376 |
FAM20C |
0.610 | -0.090 | 2 | 0.211 |
RIPK2 |
0.610 | -0.016 | 1 | 0.632 |
GRK2 |
0.610 | -0.055 | -2 | 0.525 |
GAK |
0.609 | 0.050 | 1 | 0.700 |
GCK |
0.609 | 0.075 | 1 | 0.655 |
KHS1 |
0.609 | 0.118 | 1 | 0.594 |
ACVR2B |
0.609 | -0.062 | -2 | 0.610 |
JNK3 |
0.609 | -0.005 | 1 | 0.568 |
LRRK2 |
0.609 | 0.082 | 2 | 0.445 |
PERK |
0.608 | -0.104 | -2 | 0.639 |
ROCK1 |
0.608 | 0.096 | -3 | 0.608 |
TTBK1 |
0.607 | -0.098 | 2 | 0.337 |
GRK1 |
0.607 | -0.130 | -2 | 0.563 |
P38B |
0.606 | 0.000 | 1 | 0.528 |
GRK4 |
0.606 | -0.213 | -2 | 0.620 |
NEK1 |
0.606 | 0.089 | 1 | 0.638 |
NEK4 |
0.605 | 0.014 | 1 | 0.598 |
CK1A2 |
0.605 | -0.040 | -3 | 0.363 |
ATM |
0.605 | -0.126 | 1 | 0.532 |
PASK |
0.605 | -0.030 | -3 | 0.659 |
GSK3B |
0.604 | -0.046 | 4 | 0.188 |
TLK2 |
0.604 | -0.111 | 1 | 0.552 |
BUB1 |
0.603 | 0.033 | -5 | 0.570 |
MYO3B |
0.603 | 0.133 | 2 | 0.419 |
LKB1 |
0.603 | -0.001 | -3 | 0.682 |
MEK2 |
0.603 | 0.005 | 2 | 0.449 |
DNAPK |
0.602 | -0.078 | 1 | 0.487 |
CK1D |
0.602 | -0.051 | -3 | 0.361 |
CRIK |
0.602 | 0.068 | -3 | 0.567 |
ALK2 |
0.602 | -0.090 | -2 | 0.633 |
MOK |
0.602 | 0.033 | 1 | 0.538 |
GSK3A |
0.601 | -0.034 | 4 | 0.195 |
VRK1 |
0.600 | 0.031 | 2 | 0.502 |
PBK |
0.599 | 0.036 | 1 | 0.590 |
BRAF |
0.599 | -0.131 | -4 | 0.434 |
DYRK4 |
0.599 | -0.009 | 1 | 0.493 |
CK1G1 |
0.598 | -0.080 | -3 | 0.370 |
TLK1 |
0.597 | -0.138 | -2 | 0.641 |
P38D |
0.596 | 0.010 | 1 | 0.445 |
MYO3A |
0.596 | 0.092 | 1 | 0.589 |
SLK |
0.596 | -0.029 | -2 | 0.591 |
BMPR1A |
0.595 | -0.043 | 1 | 0.651 |
SBK |
0.594 | -0.003 | -3 | 0.474 |
MST1 |
0.594 | -0.021 | 1 | 0.608 |
GRK3 |
0.594 | -0.080 | -2 | 0.495 |
YANK3 |
0.593 | -0.042 | 2 | 0.193 |
TAO1 |
0.592 | 0.047 | 1 | 0.593 |
CAMKK1 |
0.592 | -0.142 | -2 | 0.560 |
MST2 |
0.591 | -0.077 | 1 | 0.617 |
CAMKK2 |
0.588 | -0.117 | -2 | 0.560 |
OSR1 |
0.586 | -0.016 | 2 | 0.405 |
ASK1 |
0.586 | 0.044 | 1 | 0.664 |
JNK1 |
0.586 | -0.029 | 1 | 0.548 |
LIMK2_TYR |
0.585 | 0.105 | -3 | 0.699 |
BIKE |
0.585 | 0.028 | 1 | 0.589 |
TAK1 |
0.584 | -0.115 | 1 | 0.664 |
PKMYT1_TYR |
0.583 | 0.094 | 3 | 0.692 |
TTK |
0.582 | -0.033 | -2 | 0.664 |
AAK1 |
0.582 | 0.063 | 1 | 0.502 |
TNK1 |
0.582 | 0.124 | 3 | 0.641 |
CK2A2 |
0.581 | -0.065 | 1 | 0.648 |
PLK2 |
0.579 | -0.089 | -3 | 0.550 |
PINK1_TYR |
0.579 | 0.016 | 1 | 0.726 |
LIMK1_TYR |
0.577 | 0.033 | 2 | 0.453 |
TESK1_TYR |
0.576 | -0.018 | 3 | 0.702 |
ROS1 |
0.575 | 0.051 | 3 | 0.666 |
PDHK3_TYR |
0.575 | -0.073 | 4 | 0.591 |
MAP2K7_TYR |
0.574 | -0.073 | 2 | 0.447 |
CK2A1 |
0.573 | -0.066 | 1 | 0.646 |
TYRO3 |
0.573 | 0.012 | 3 | 0.681 |
BMPR2_TYR |
0.572 | -0.044 | -1 | 0.576 |
WEE1_TYR |
0.572 | 0.042 | -1 | 0.496 |
TNNI3K_TYR |
0.570 | 0.044 | 1 | 0.570 |
MST1R |
0.569 | 0.005 | 3 | 0.671 |
MAP2K4_TYR |
0.569 | -0.138 | -1 | 0.608 |
DDR1 |
0.569 | -0.007 | 4 | 0.558 |
TYK2 |
0.568 | -0.008 | 1 | 0.624 |
CK1A |
0.567 | -0.087 | -3 | 0.285 |
JAK1 |
0.566 | 0.046 | 1 | 0.606 |
TNK2 |
0.566 | 0.006 | 3 | 0.674 |
CSF1R |
0.565 | -0.018 | 3 | 0.674 |
PDHK4_TYR |
0.565 | -0.139 | 2 | 0.440 |
NEK10_TYR |
0.565 | 0.015 | 1 | 0.640 |
JAK2 |
0.565 | -0.021 | 1 | 0.635 |
JAK3 |
0.564 | -0.027 | 1 | 0.679 |
MAP2K6_TYR |
0.564 | -0.182 | -1 | 0.604 |
YES1 |
0.563 | -0.060 | -1 | 0.517 |
RET |
0.562 | -0.090 | 1 | 0.642 |
STLK3 |
0.562 | -0.117 | 1 | 0.597 |
PDGFRB |
0.561 | -0.040 | 3 | 0.692 |
YANK2 |
0.561 | -0.063 | 2 | 0.175 |
FGR |
0.561 | -0.078 | 1 | 0.684 |
KDR |
0.560 | -0.029 | 3 | 0.636 |
FLT3 |
0.560 | -0.022 | 3 | 0.691 |
EPHA6 |
0.559 | -0.083 | -1 | 0.490 |
PDGFRA |
0.559 | -0.017 | 3 | 0.702 |
AXL |
0.558 | -0.039 | 3 | 0.629 |
PDHK1_TYR |
0.558 | -0.209 | -1 | 0.579 |
HCK |
0.556 | -0.075 | -1 | 0.463 |
INSRR |
0.555 | -0.090 | 3 | 0.640 |
TEK |
0.554 | -0.076 | 3 | 0.650 |
LCK |
0.554 | -0.061 | -1 | 0.459 |
DDR2 |
0.554 | -0.019 | 3 | 0.669 |
FGFR1 |
0.554 | -0.061 | 3 | 0.640 |
FGFR2 |
0.553 | -0.099 | 3 | 0.654 |
KIT |
0.553 | -0.074 | 3 | 0.681 |
ALK |
0.553 | -0.037 | 3 | 0.656 |
ITK |
0.551 | -0.083 | -1 | 0.447 |
FER |
0.551 | -0.136 | 1 | 0.658 |
ALPHAK3 |
0.551 | -0.147 | -1 | 0.494 |
PTK2B |
0.551 | -0.020 | -1 | 0.440 |
MERTK |
0.549 | -0.076 | 3 | 0.606 |
BLK |
0.548 | -0.083 | -1 | 0.467 |
ABL2 |
0.548 | -0.123 | -1 | 0.451 |
TXK |
0.547 | -0.089 | 1 | 0.699 |
INSR |
0.547 | -0.090 | 3 | 0.617 |
EPHB4 |
0.546 | -0.169 | -1 | 0.463 |
NTRK2 |
0.546 | -0.088 | 3 | 0.633 |
MET |
0.545 | -0.114 | 3 | 0.650 |
ABL1 |
0.545 | -0.133 | -1 | 0.445 |
BTK |
0.544 | -0.143 | -1 | 0.424 |
LTK |
0.544 | -0.085 | 3 | 0.645 |
MUSK |
0.544 | -0.030 | 1 | 0.573 |
FLT4 |
0.543 | -0.105 | 3 | 0.624 |
FGFR3 |
0.543 | -0.113 | 3 | 0.632 |
TEC |
0.543 | -0.106 | -1 | 0.402 |
FYN |
0.541 | -0.093 | -1 | 0.451 |
BMX |
0.541 | -0.104 | -1 | 0.387 |
NTRK1 |
0.541 | -0.142 | -1 | 0.460 |
LYN |
0.540 | -0.105 | 3 | 0.634 |
EPHA1 |
0.540 | -0.099 | 3 | 0.640 |
FRK |
0.540 | -0.086 | -1 | 0.443 |
SRC |
0.540 | -0.093 | -1 | 0.451 |
NTRK3 |
0.540 | -0.092 | -1 | 0.414 |
SRMS |
0.540 | -0.162 | 1 | 0.657 |
EPHB1 |
0.539 | -0.158 | 1 | 0.632 |
EPHA4 |
0.538 | -0.163 | 2 | 0.367 |
CK1G3 |
0.538 | -0.105 | -3 | 0.244 |
PTK6 |
0.538 | -0.156 | -1 | 0.398 |
ERBB2 |
0.537 | -0.148 | 1 | 0.639 |
FLT1 |
0.536 | -0.151 | -1 | 0.446 |
EPHB3 |
0.536 | -0.173 | -1 | 0.428 |
MATK |
0.535 | -0.111 | -1 | 0.402 |
PTK2 |
0.534 | -0.067 | -1 | 0.440 |
IGF1R |
0.533 | -0.093 | 3 | 0.567 |
EPHB2 |
0.533 | -0.175 | -1 | 0.412 |
EPHA3 |
0.531 | -0.169 | 2 | 0.371 |
EPHA7 |
0.529 | -0.153 | 2 | 0.376 |
FES |
0.527 | -0.059 | -1 | 0.367 |
EGFR |
0.527 | -0.119 | 1 | 0.593 |
EPHA8 |
0.523 | -0.148 | -1 | 0.411 |
CSK |
0.523 | -0.163 | 2 | 0.398 |
FGFR4 |
0.522 | -0.140 | -1 | 0.395 |
EPHA5 |
0.517 | -0.192 | 2 | 0.360 |
SYK |
0.516 | -0.132 | -1 | 0.393 |
CK1G2 |
0.516 | -0.126 | -3 | 0.312 |
EPHA2 |
0.512 | -0.160 | -1 | 0.369 |
ERBB4 |
0.511 | -0.124 | 1 | 0.575 |
ZAP70 |
0.509 | -0.098 | -1 | 0.396 |