Motif 70 (n=162)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L020 | MEX3A | S308 | ochoa | RNA-binding protein MEX3A (RING finger and KH domain-containing protein 4) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. |
| A5PL33 | KRBA1 | S288 | ochoa | Protein KRBA1 | None |
| A6NJZ7 | RIMBP3C | S1294 | ochoa | RIMS-binding protein 3C (RIM-BP3.C) (RIMS-binding protein 3.3) (RIM-BP3.3) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| A6NNM3 | RIMBP3B | S1294 | ochoa | RIMS-binding protein 3B (RIM-BP3.B) (RIMS-binding protein 3.2) (RIM-BP3.2) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| A7XYQ1 | SOBP | S629 | ochoa | Sine oculis-binding protein homolog (Jackson circler protein 1) | Implicated in development of the cochlea. {ECO:0000250|UniProtKB:Q0P5V2}. |
| A8MYA2 | CXorf49; | S28 | ochoa | Uncharacterized protein CXorf49 | None |
| A8MYZ6 | FOXO6 | S275 | ochoa | Forkhead box protein O6 | Transcriptional activator. {ECO:0000250}. |
| B2RTY4 | MYO9A | S1299 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| C9J4A7 | None | S89 | ochoa | PH domain-containing protein | None |
| H3BU86 | STX16-NPEPL1 | S35 | ochoa | Syntaxin-16 | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000256|ARBA:ARBA00037772}. |
| K7EQG2 | None | S86 | ochoa | Uncharacterized protein | None |
| O00213 | APBB1 | S347 | ochoa|psp | Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65) | Transcription coregulator that can have both coactivator and corepressor functions (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469, PubMed:33938178). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 (PubMed:19234442). Required for histone H4 acetylation at double-strand breaks (DSBs) (PubMed:19234442). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:33938178). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 (PubMed:19343227). Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Plays a role in the maintenance of lens transparency (By similarity). May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (PubMed:36250347). {ECO:0000250|UniProtKB:Q9QXJ1, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:18468999, ECO:0000269|PubMed:18922798, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:36250347}. |
| O00268 | TAF4 | S543 | ochoa | Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867). {ECO:0000269|PubMed:10594036, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8942982, ECO:0000269|PubMed:9192867}. |
| O14662 | STX16 | S35 | ochoa | Syntaxin-16 (Syn16) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O14686 | KMT2D | S1606 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S3199 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14827 | RASGRF2 | S848 | ochoa | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
| O15020 | SPTBN2 | S1853 | ochoa | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| O15379 | HDAC3 | S74 | ochoa | Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates (PubMed:21030595, PubMed:21444723, PubMed:23911289, PubMed:25301942, PubMed:28167758, PubMed:28497810, PubMed:32404892, PubMed:22230954). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:23911289). Histone deacetylases act via the formation of large multiprotein complexes, such as N-Cor repressor complex, which activate the histone deacetylase activity (PubMed:23911289, PubMed:22230954). Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression (PubMed:23911289). Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity). During the activation phase, promotes the accumulation of ubiquitinated BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and BMAL1 (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Also functions as a deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14, RARA and STAT3 (PubMed:15653507, PubMed:21030595, PubMed:21444723, PubMed:25301942, PubMed:28167758). Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:34608293, PubMed:35044827). Catalyzes decrotonylation of MAPRE1/EB1 (PubMed:34608293). Mediates delactylation NBN/NBS1, thereby inhibiting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250|UniProtKB:O88895, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21444723, ECO:0000269|PubMed:22230954, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25301942, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:32404892, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:38961290}. |
| O43520 | ATP8B1 | S1232 | ochoa | Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (PubMed:17948906, PubMed:25315773). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (PubMed:20512993). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:25239307, PubMed:27301931). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (PubMed:20510206). Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity). {ECO:0000250|UniProtKB:Q148W0, ECO:0000269|PubMed:17948906, ECO:0000269|PubMed:20510206, ECO:0000269|PubMed:20512993, ECO:0000269|PubMed:25239307, ECO:0000269|PubMed:27301931}. |
| O60287 | URB1 | S1097 | ochoa | Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog) | None |
| O60303 | KATNIP | S660 | ochoa | Katanin-interacting protein | May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269|PubMed:26714646}. |
| O60343 | TBC1D4 | S806 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O75376 | NCOR1 | S1111 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75410 | TACC1 | S287 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75604 | USP2 | S225 | psp | Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) | Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19838211, PubMed:19917254). Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (PubMed:17290220, PubMed:19838211). Has no deubiquitinase activity against p53/TP53 (PubMed:17290220). Prevents MDM2-mediated degradation of MDM4 (PubMed:17290220). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (PubMed:19917254). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (By similarity). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (By similarity). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and BMAL1 (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity). {ECO:0000250|UniProtKB:O88623, ECO:0000250|UniProtKB:Q5U349, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19838211, ECO:0000269|PubMed:19917254}.; FUNCTION: [Isoform 4]: Circadian clock output effector that regulates Ca(2+) absorption in the small intestine. Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca(2+) membrane permeability mediated by the Ca(2+) channel TRPV6 in the intestine. {ECO:0000250|UniProtKB:O88623}. |
| O75643 | SNRNP200 | S932 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O75828 | CBR3 | S56 | ochoa | Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2) | Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841). Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin (PubMed:15537833, PubMed:18493841, PubMed:19841672). Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19841672). Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (PubMed:19841672). {ECO:0000269|PubMed:15537833, ECO:0000269|PubMed:18493841, ECO:0000269|PubMed:19841672}. |
| O94818 | NOL4 | S309 | ochoa | Nucleolar protein 4 (Nucleolar-localized protein) | None |
| O94941 | UBOX5 | S388 | ochoa | RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5) | May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. {ECO:0000250|UniProtKB:Q925F4}. |
| O95677 | EYA4 | S131 | ochoa | Protein phosphatase EYA4 (EC 3.1.3.48) (Eyes absent homolog 4) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250|UniProtKB:Q99502}. |
| P04424 | ASL | S417 | psp | Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) | Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (PubMed:11747432, PubMed:11747433, PubMed:22081021, PubMed:2263616, PubMed:9045711). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (PubMed:22081021). {ECO:0000269|PubMed:11747432, ECO:0000269|PubMed:11747433, ECO:0000269|PubMed:22081021, ECO:0000269|PubMed:9045711}. |
| P06732 | CKM | S199 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
| P0DMU7 | CT45A6 | S24 | ochoa | Cancer/testis antigen family 45 member A6 (Cancer/testis antigen 45-6) (Cancer/testis antigen 45A6) | None |
| P0DMU8 | CT45A5 | S24 | ochoa | Cancer/testis antigen family 45 member A5 (Cancer/testis antigen 45-5) (Cancer/testis antigen 45A5) | None |
| P0DMU9 | CT45A10 | S24 | ochoa | Cancer/testis antigen family 45 member A10 (Cancer/testis antigen 45A10) | None |
| P0DMV0 | CT45A7 | S24 | ochoa | Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7) | None |
| P0DMV1 | CT45A8 | S24 | ochoa | Cancer/testis antigen family 45 member A8 (Cancer/testis antigen 45A8) | None |
| P0DMV2 | CT45A9 | S24 | ochoa | Cancer/testis antigen family 45 member A9 (Cancer/testis antigen 45A9) | None |
| P10070 | GLI2 | S92 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P10070 | GLI2 | S1194 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P10636 | MAPT | S46 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P12277 | CKB | S199 | ochoa | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| P13056 | NR2C1 | S101 | ochoa | Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2) | Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. {ECO:0000269|PubMed:12093804, ECO:0000269|PubMed:17010934}. |
| P16152 | CBR1 | S56 | ochoa | Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). {ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943, ECO:0000269|PubMed:1921984, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:7005231}. |
| P17540 | CKMT2 | S233 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P18887 | XRCC1 | S140 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P20618 | PSMB1 | S68 | ochoa | Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P22314 | UBA1 | S835 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P31150 | GDI1 | S222 | ochoa | Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4) | Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269|PubMed:23815289}. |
| P41235 | HNF4A | S378 | psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P46782 | RPS5 | S142 | ochoa | Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)] | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P46937 | YAP1 | S340 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P48436 | SOX9 | S211 | ochoa|psp | Transcription factor SOX-9 | Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). {ECO:0000250|UniProtKB:Q04887, ECO:0000269|PubMed:24038782, ECO:0000269|PubMed:8640233}. |
| P48551 | IFNAR2 | S400 | ochoa|psp | Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2) | Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:17517919, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:10556041, PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT) (PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:12105218, PubMed:28165510, PubMed:9121453). {ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:10556041, ECO:0000269|PubMed:11682488, ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:17517919, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:26424569, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059, ECO:0000269|PubMed:8798579, ECO:0000269|PubMed:8969169, ECO:0000269|PubMed:9121453}.; FUNCTION: [Isoform 3]: Potent inhibitor of type I IFN receptor activity. {ECO:0000269|PubMed:7759950}. |
| P49327 | FASN | S1411 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49662 | CASP4 | S83 | ochoa | Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20] | Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:25119034, PubMed:26375003, PubMed:32109412, PubMed:34671164, PubMed:37001519, PubMed:37993712, PubMed:37993714). Also indirectly activates the NLRP3 and NLRP6 inflammasomes (PubMed:23516580, PubMed:26375003, PubMed:32109412, PubMed:7797510). Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS, GSDMD and IL18 (PubMed:15326478, PubMed:23516580, PubMed:26375003, PubMed:28314590, PubMed:32109412, PubMed:37993712, PubMed:37993714, PubMed:7797510). Effector of the non-canonical inflammasome independently of NLRP3 inflammasome and CASP1: the non-canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine IL1B (PubMed:25119034, PubMed:25121752, PubMed:26375003, PubMed:31268602, PubMed:32109412, PubMed:37993712, PubMed:37993714). In the non-canonical inflammasome, CASP4 is activated by direct binding to the lipid A moiety of LPS without the need of an upstream sensor (PubMed:25119034, PubMed:25121752, PubMed:29520027, PubMed:32510692, PubMed:32581219, PubMed:37993712). LPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD and IL18, followed by IL18 secretion through the GSDMD pore, pyroptosis of infected cells and their extrusion into the gut lumen (PubMed:25119034, PubMed:25121752, PubMed:37993712, PubMed:37993714). Also indirectly promotes secretion of mature cytokines (IL1A and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (PubMed:26375003, PubMed:32109412). Involved in NLRP3-dependent CASP1 activation and IL1B secretion in response to non-canonical activators, such as UVB radiation or cholera enterotoxin (PubMed:22246630, PubMed:23516580, PubMed:24879791, PubMed:25964352, PubMed:26173988, PubMed:26174085, PubMed:26508369). Involved in NLRP6 inflammasome-dependent activation in response to lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, which leads to CASP1 activation and IL1B secretion (PubMed:33377178). Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). The non-canonical inflammasome is required for innate immunity to cytosolic, but not vacuolar, bacteria (By similarity). Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection (PubMed:25121752, PubMed:25964352). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (By similarity). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752, PubMed:25964352, PubMed:26375003). May also act as an activator of adaptive immunity in dendritic cells, following activation by oxidized phospholipid 1-palmitoyl-2-arachidonoyl- sn-glycero-3-phosphorylcholine, an oxidized phospholipid (oxPAPC) (By similarity). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found in Alzheimer's patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Catalyzes cleavage and maturation of IL18; IL18 processing also depends of the exosite interface on CASP4 (PubMed:15326478, PubMed:37993712, PubMed:37993714). In contrast, it does not directly process IL1B (PubMed:7743998, PubMed:7797510, PubMed:7797592). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). {ECO:0000250|UniProtKB:P70343, ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:15326478, ECO:0000269|PubMed:22246630, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:23661706, ECO:0000269|PubMed:24879791, ECO:0000269|PubMed:25119034, ECO:0000269|PubMed:25121752, ECO:0000269|PubMed:25964352, ECO:0000269|PubMed:26173988, ECO:0000269|PubMed:26174085, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26508369, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:29520027, ECO:0000269|PubMed:31268602, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32510692, ECO:0000269|PubMed:32581219, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:34671164, ECO:0000269|PubMed:37001519, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7743998, ECO:0000269|PubMed:7797510, ECO:0000269|PubMed:7797592}.; FUNCTION: (Microbial infection) In response to the Td92 surface protein of the periodontal pathogen T.denticola, activated by cathepsin CTSG which leads to production and secretion of IL1A and pyroptosis of gingival fibroblasts. {ECO:0000269|PubMed:29077095}. |
| P50395 | GDI2 | S222 | ochoa | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P53621 | COPA | S915 | ochoa | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| P84550 | SKOR1 | S748 | ochoa | SKI family transcriptional corepressor 1 (Functional Smad-suppressing element on chromosome 15) (Fussel-15) (LBX1 corepressor 1) (Ladybird homeobox corepressor 1) | Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling. {ECO:0000250}. |
| Q02241 | KIF23 | S902 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q02779 | MAP3K10 | S502 | ochoa | Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) | Activates the JUN N-terminal pathway. {ECO:0000250}. |
| Q03001 | DST | S3025 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q06413 | MEF2C | S228 | ochoa | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q0IIM8 | TBC1D8B | S718 | ochoa | TBC1 domain family member 8B | Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein. {ECO:0000269|PubMed:30661770}. |
| Q0VF96 | CGNL1 | S261 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q10571 | MN1 | S1007 | ochoa | Transcriptional activator MN1 (Probable tumor suppressor protein MN1) | Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}. |
| Q12802 | AKAP13 | S2398 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12955 | ANK3 | S4229 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13129 | RLF | S632 | ochoa | Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) | May be involved in transcriptional regulation. |
| Q13387 | MAPK8IP2 | S364 | ochoa | C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). {ECO:0000250}. |
| Q13428 | TCOF1 | S503 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14145 | KEAP1 | S104 | psp | Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15601839, PubMed:15983046, PubMed:37339955). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:19489739, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835). {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16006525, ECO:0000269|PubMed:17046835, ECO:0000269|PubMed:17127771, ECO:0000269|PubMed:18251510, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:37339955}. |
| Q14694 | USP10 | S211 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14934 | NFATC4 | S122 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q15003 | NCAPH | S87 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15349 | RPS6KA2 | S679 | ochoa | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q15477 | SKIC2 | S245 | ochoa | Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) | Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}. |
| Q15596 | NCOA2 | S655 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q16836 | HADH | S290 | ochoa | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity). {ECO:0000250|UniProtKB:Q61425, ECO:0000269|PubMed:10231530, ECO:0000269|PubMed:11489939, ECO:0000269|PubMed:16725361}. |
| Q32MQ0 | ZNF750 | S136 | ochoa | Zinc finger protein 750 | Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression. {ECO:0000269|PubMed:22364861}. |
| Q3KP66 | INAVA | S643 | ochoa | Innate immunity activator protein | Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). {ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}. |
| Q3L8U1 | CHD9 | S2303 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q3MIP1 | ITPRIPL2 | S139 | ochoa | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 | None |
| Q4KMZ1 | IQCC | S196 | ochoa | IQ domain-containing protein C | None |
| Q4KMZ1 | IQCC | S253 | ochoa | IQ domain-containing protein C | None |
| Q5DJT8 | CT45A2 | S24 | ochoa | Cancer/testis antigen family 45 member A2 (Cancer/testis antigen 45-2) (Cancer/testis antigen 45A2) | None |
| Q5GLZ8 | HERC4 | S180 | ochoa | Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4) | Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. {ECO:0000250|UniProtKB:Q6PAV2}. |
| Q5HYN5 | CT45A1 | S24 | ochoa | Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1) | None |
| Q5R3F8 | ELFN2 | S668 | ochoa | Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| Q5T011 | SZT2 | S1825 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5TAX3 | TUT4 | S296 | ochoa | Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}. |
| Q5VZ89 | DENND4C | S1244 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q68DQ2 | CRYBG3 | S1934 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6PIY7 | TENT2 | S69 | ochoa | Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2) | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail (PubMed:15070731, PubMed:31792053). In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856, PubMed:31792053). {ECO:0000269|PubMed:15070731, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:23200856, ECO:0000269|PubMed:31792053}. |
| Q70SY1 | CREB3L2 | S191 | ochoa | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}. |
| Q7Z5J4 | RAI1 | S880 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z5J4 | RAI1 | S916 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z5J4 | RAI1 | S1013 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q86UP2 | KTN1 | S243 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86V25 | VASH2 | S302 | ochoa | Tubulinyl-Tyr carboxypeptidase 2 (EC 3.4.17.17) (Vasohibin-2) (Vasohibin-like protein) | Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911). {ECO:0000269|PubMed:19204325, ECO:0000269|PubMed:29146869, ECO:0000269|PubMed:31235911}. |
| Q86VW2 | ARHGEF25 | S477 | ochoa | Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF) | May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:11861769, ECO:0000269|PubMed:12547822, ECO:0000269|PubMed:15069594, ECO:0000269|PubMed:15632174, ECO:0000269|PubMed:16314529, ECO:0000269|PubMed:17606614}. |
| Q8IXJ9 | ASXL1 | S503 | ochoa | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:30664650, PubMed:36180891). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000250|UniProtKB:P59598, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:30982744, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:36180891}. |
| Q8IXZ2 | ZC3H3 | S920 | ochoa | Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) | Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity). {ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}. |
| Q8IY63 | AMOTL1 | S930 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8IY67 | RAVER1 | S512 | ochoa | Ribonucleoprotein PTB-binding 1 (Protein raver-1) | Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}. |
| Q8N1G0 | ZNF687 | S433 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N2G6 | ZCCHC24 | S65 | ochoa | Zinc finger CCHC domain-containing protein 24 | None |
| Q8N3K9 | CMYA5 | S168 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N5C8 | TAB3 | S60 | ochoa|psp | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8N9M5 | TMEM102 | S218 | ochoa | Transmembrane protein 102 (Common beta-chain associated protein) (CBAP) | Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. {ECO:0000269|PubMed:17828305}. |
| Q8NF91 | SYNE1 | S8250 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NHU0 | CT45A3 | S24 | ochoa | Cancer/testis antigen family 45 member A3 (Cancer/testis antigen 45-3) (Cancer/testis antigen 45-4) (Cancer/testis antigen 45A3) (Cancer/testis antigen 45A4) (Cancer/testis antigen family 45 member A4) | None |
| Q8TD55 | PLEKHO2 | S89 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TER5 | ARHGEF40 | S262 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8WUF5 | PPP1R13L | S316 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q92585 | MAML1 | S338 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92613 | JADE3 | S741 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92620 | DHX38 | S1194 | ochoa | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) | Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131). {ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:9524131, ECO:0000305}. |
| Q92625 | ANKS1A | S771 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q92692 | NECTIN2 | S433 | ochoa | Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}. |
| Q92738 | USP6NL | S689 | ochoa | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}. |
| Q92797 | SYMPK | S938 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q92888 | ARHGEF1 | S333 | ochoa | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q96A47 | ISL2 | S157 | ochoa | Insulin gene enhancer protein ISL-2 (Islet-2) | Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. {ECO:0000250}. |
| Q96GY0 | ZC2HC1A | S292 | ochoa | Zinc finger C2HC domain-containing protein 1A | None |
| Q96HI0 | SENP5 | S465 | ochoa | Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) | Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}. |
| Q96JQ0 | DCHS1 | S2995 | ochoa | Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) | Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}. |
| Q96PC5 | MIA2 | S1144 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96PX6 | CCDC85A | S358 | ochoa | Coiled-coil domain-containing protein 85A | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family. {ECO:0000305|PubMed:25009281}. |
| Q96RY7 | IFT140 | S360 | ochoa | Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2) | Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (PubMed:20889716, PubMed:22503633). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22503633). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity). {ECO:0000250|UniProtKB:E9PY46, ECO:0000269|PubMed:20889716, ECO:0000269|PubMed:22503633, ECO:0000269|PubMed:28724397}. |
| Q96S19 | METTL26 | S149 | ochoa | Methyltransferase-like 26 | None |
| Q9BQ39 | DDX50 | S464 | ochoa | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q9BSJ8 | ESYT1 | S324 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BTC8 | MTA3 | S519 | ochoa | Metastasis-associated protein MTA3 | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q9BU70 | TRMO | S118 | ochoa | tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O) | S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability (By similarity). {ECO:0000250|UniProtKB:P28634, ECO:0000269|PubMed:25063302}. |
| Q9BUH8 | BEGAIN | S502 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BYG4 | PARD6G | S351 | ochoa | Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D) | Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). {ECO:0000250}. |
| Q9C0D2 | CEP295 | S1388 | ochoa | Centrosomal protein of 295 kDa | Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}. |
| Q9C0K0 | BCL11B | S97 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H2A7 | CXCL16 | S234 | ochoa | C-X-C motif chemokine 16 (Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein) (SR-PSOX) (Small-inducible cytokine B16) (Transmembrane chemokine CXCL16) | Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. {ECO:0000250}. |
| Q9H611 | PIF1 | S27 | ochoa | ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721, ECO:0000269|PubMed:18835853, ECO:0000269|PubMed:19700773, ECO:0000269|PubMed:20524933, ECO:0000269|PubMed:23657261}. |
| Q9H792 | PEAK1 | S1036 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H7N4 | SCAF1 | S874 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9HC44 | GPBP1L1 | S21 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
| Q9NPG3 | UBN1 | S323 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NR30 | DDX21 | S513 | ochoa | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NSI2 | SLX9 | S209 | ochoa | Ribosome biogenesis protein SLX9 homolog | May be involved in ribosome biogenesis. {ECO:0000250|UniProtKB:P53251}. |
| Q9NYD6 | HOXC10 | S61 | ochoa | Homeobox protein Hox-C10 (Homeobox protein Hox-3I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Q9NZ56 | FMN2 | S295 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9P2F8 | SIPA1L2 | S379 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UFD9 | RIMBP3 | S1294 | ochoa | RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| Q9UKZ1 | CNOT11 | S336 | ochoa | CCR4-NOT transcription complex subunit 11 | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function. |
| Q9ULJ3 | ZBTB21 | S504 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULV5 | HSF4 | S298 | psp | Heat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4) | Heat-shock transcription factor that specifically binds heat shock promoter elements (HSE) (PubMed:22587838, PubMed:23507146). Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (By similarity). In this process, may regulate denucleation of lens fiber cells in part by activating DNASE2B transcription (By similarity). May be involved in DNA repair through the transcriptional regulation of RAD51 (PubMed:22587838). May up-regulate p53/TP53 protein in eye lens fiber cells, possibly through protein stabilization (PubMed:28981088). In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q5CZP2, ECO:0000250|UniProtKB:Q9R0L1, ECO:0000269|PubMed:22587838, ECO:0000269|PubMed:23507146, ECO:0000269|PubMed:28981088}.; FUNCTION: [Isoform HSF4A]: Transcriptional repressor. {ECO:0000269|PubMed:10488131}.; FUNCTION: [Isoform HSF4B]: Transcriptional activator. {ECO:0000269|PubMed:10488131, ECO:0000269|PubMed:16371476}. |
| Q9UQM7 | CAMK2A | S404 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y2I6 | NINL | S585 | ochoa|psp | Ninein-like protein | Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}. |
| Q9Y4B5 | MTCL1 | S1588 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4D8 | HECTD4 | S595 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q9Y4F1 | FARP1 | S510 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y5Y5 | PEX16 | S138 | ochoa | Peroxisomal membrane protein PEX16 (Peroxin-16) (Peroxisomal biogenesis factor 16) | Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:12223482, ECO:0000269|PubMed:16717127}. |
| P08684 | CYP3A4 | S134 | EPSD|PSP | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.000014 | 4.839 |
| R-HSA-9707616 | Heme signaling | 0.000145 | 3.840 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.000741 | 3.130 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.000668 | 3.175 |
| R-HSA-186712 | Regulation of beta-cell development | 0.000967 | 3.014 |
| R-HSA-9909396 | Circadian clock | 0.001411 | 2.850 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.001729 | 2.762 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.003669 | 2.435 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.003873 | 2.412 |
| R-HSA-71288 | Creatine metabolism | 0.002824 | 2.549 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.003620 | 2.441 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.003152 | 2.501 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.003296 | 2.482 |
| R-HSA-73887 | Death Receptor Signaling | 0.003247 | 2.489 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.005650 | 2.248 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.005835 | 2.234 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.005361 | 2.271 |
| R-HSA-5620971 | Pyroptosis | 0.006609 | 2.180 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.009584 | 2.018 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.010956 | 1.960 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.008937 | 2.049 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.010959 | 1.960 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.010759 | 1.968 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.009584 | 2.018 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.008331 | 2.079 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.007912 | 2.102 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 0.017282 | 1.762 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 0.017282 | 1.762 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 0.017282 | 1.762 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 0.017282 | 1.762 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.015526 | 1.809 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.012442 | 1.905 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.013852 | 1.858 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.013852 | 1.858 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.013852 | 1.858 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.015806 | 1.801 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.016739 | 1.776 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.015450 | 1.811 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.015211 | 1.818 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.016416 | 1.785 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.012972 | 1.887 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.015789 | 1.802 |
| R-HSA-9948011 | CASP5 inflammasome assembly | 0.021866 | 1.660 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.023022 | 1.638 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 0.023022 | 1.638 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.022571 | 1.646 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.036463 | 1.438 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.041516 | 1.382 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.031781 | 1.498 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.025933 | 1.586 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.033395 | 1.476 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.040374 | 1.394 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.040374 | 1.394 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.040374 | 1.394 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.040374 | 1.394 |
| R-HSA-9843745 | Adipogenesis | 0.024461 | 1.612 |
| R-HSA-429947 | Deadenylation of mRNA | 0.044067 | 1.356 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.035603 | 1.449 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.037610 | 1.425 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.040374 | 1.394 |
| R-HSA-2028269 | Signaling by Hippo | 0.025087 | 1.601 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.038924 | 1.410 |
| R-HSA-198753 | ERK/MAPK targets | 0.034053 | 1.468 |
| R-HSA-844615 | The AIM2 inflammasome | 0.043257 | 1.364 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.036342 | 1.440 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.046446 | 1.333 |
| R-HSA-450294 | MAP kinase activation | 0.041852 | 1.378 |
| R-HSA-9831926 | Nephron development | 0.027224 | 1.565 |
| R-HSA-4839726 | Chromatin organization | 0.030945 | 1.509 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 0.053778 | 1.269 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 0.053778 | 1.269 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.053778 | 1.269 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.053778 | 1.269 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.052200 | 1.282 |
| R-HSA-844623 | The IPAF inflammasome | 0.053778 | 1.269 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.052200 | 1.282 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.055021 | 1.259 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.057895 | 1.237 |
| R-HSA-448424 | Interleukin-17 signaling | 0.056344 | 1.249 |
| R-HSA-5218859 | Regulated Necrosis | 0.052941 | 1.276 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.070956 | 1.149 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.070915 | 1.149 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.070915 | 1.149 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.070915 | 1.149 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.073001 | 1.137 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.064183 | 1.193 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.067157 | 1.173 |
| R-HSA-9733709 | Cardiogenesis | 0.069886 | 1.156 |
| R-HSA-199991 | Membrane Trafficking | 0.069007 | 1.161 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.066650 | 1.176 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.064252 | 1.192 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.074475 | 1.128 |
| R-HSA-174577 | Activation of C3 and C5 | 0.074475 | 1.128 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.074475 | 1.128 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 0.074475 | 1.128 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.094721 | 1.024 |
| R-HSA-444257 | RSK activation | 0.114527 | 0.941 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.095966 | 1.018 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.102863 | 0.988 |
| R-HSA-167161 | HIV Transcription Initiation | 0.102863 | 0.988 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.102863 | 0.988 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.087086 | 1.060 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.117042 | 0.932 |
| R-HSA-448706 | Interleukin-1 processing | 0.124268 | 0.906 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.119833 | 0.921 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.084654 | 1.072 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.109891 | 0.959 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.102863 | 0.988 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.116210 | 0.935 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.124268 | 0.906 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 0.117042 | 0.932 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.114527 | 0.941 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.124307 | 0.906 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.124268 | 0.906 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.094253 | 1.026 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.111584 | 0.952 |
| R-HSA-444821 | Relaxin receptors | 0.084654 | 1.072 |
| R-HSA-199920 | CREB phosphorylation | 0.094721 | 1.024 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.124268 | 0.906 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.095966 | 1.018 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.118587 | 0.926 |
| R-HSA-8874211 | CREB3 factors activate genes | 0.094721 | 1.024 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.085888 | 1.066 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.120981 | 0.917 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.120981 | 0.917 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.120981 | 0.917 |
| R-HSA-74160 | Gene expression (Transcription) | 0.107491 | 0.969 |
| R-HSA-1266738 | Developmental Biology | 0.097218 | 1.012 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.124268 | 0.906 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.092501 | 1.034 |
| R-HSA-2262752 | Cellular responses to stress | 0.113373 | 0.945 |
| R-HSA-212436 | Generic Transcription Pathway | 0.101576 | 0.993 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.076160 | 1.118 |
| R-HSA-5357801 | Programmed Cell Death | 0.105691 | 0.976 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.124500 | 0.905 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 0.133903 | 0.873 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.152856 | 0.816 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.162178 | 0.790 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.171397 | 0.766 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.207278 | 0.683 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.241612 | 0.617 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.258221 | 0.588 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.266389 | 0.574 |
| R-HSA-72187 | mRNA 3'-end processing | 0.142914 | 0.845 |
| R-HSA-1989781 | PPARA activates gene expression | 0.126395 | 0.898 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.250110 | 0.602 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.130222 | 0.885 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.328596 | 0.483 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.249963 | 0.602 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.198455 | 0.702 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 0.162178 | 0.790 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 0.162178 | 0.790 |
| R-HSA-9956593 | Microbial factors inhibit CASP4 activity | 0.171397 | 0.766 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.171397 | 0.766 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.162178 | 0.790 |
| R-HSA-9620244 | Long-term potentiation | 0.290361 | 0.537 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.217632 | 0.662 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.313554 | 0.504 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.138224 | 0.859 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.138224 | 0.859 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.180516 | 0.743 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.331353 | 0.480 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.177672 | 0.750 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.133903 | 0.873 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.189535 | 0.722 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.207278 | 0.683 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.258221 | 0.588 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.258221 | 0.588 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.282459 | 0.549 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.305908 | 0.514 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.313554 | 0.504 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.177690 | 0.750 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.335993 | 0.474 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.205364 | 0.687 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.229777 | 0.639 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.364781 | 0.438 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.180516 | 0.743 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.241612 | 0.617 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.270495 | 0.568 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.217632 | 0.662 |
| R-HSA-5689603 | UCH proteinases | 0.237900 | 0.624 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.323298 | 0.490 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.181254 | 0.742 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.224794 | 0.648 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.152856 | 0.816 |
| R-HSA-9754706 | Atorvastatin ADME | 0.198455 | 0.702 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 0.207278 | 0.683 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.233170 | 0.632 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.249963 | 0.602 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.249963 | 0.602 |
| R-HSA-420029 | Tight junction interactions | 0.290361 | 0.537 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.343309 | 0.464 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.364781 | 0.438 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.371782 | 0.430 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.371782 | 0.430 |
| R-HSA-157118 | Signaling by NOTCH | 0.324329 | 0.489 |
| R-HSA-167172 | Transcription of the HIV genome | 0.205548 | 0.687 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.152856 | 0.816 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.162178 | 0.790 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.171397 | 0.766 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 0.189535 | 0.722 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.198455 | 0.702 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.335993 | 0.474 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.335993 | 0.474 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.262339 | 0.581 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.233170 | 0.632 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.321116 | 0.493 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.328596 | 0.483 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.255604 | 0.592 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.208203 | 0.682 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.143432 | 0.843 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.143432 | 0.843 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.189535 | 0.722 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.258221 | 0.588 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.173760 | 0.760 |
| R-HSA-9930044 | Nuclear RNA decay | 0.350546 | 0.455 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.357703 | 0.446 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.364781 | 0.438 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.364781 | 0.438 |
| R-HSA-169911 | Regulation of Apoptosis | 0.371782 | 0.430 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.290058 | 0.538 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.189561 | 0.722 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.229777 | 0.639 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.229471 | 0.639 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.133903 | 0.873 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.229777 | 0.639 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.290361 | 0.537 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.290361 | 0.537 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.148433 | 0.828 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.164589 | 0.784 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 0.207278 | 0.683 |
| R-HSA-525793 | Myogenesis | 0.298178 | 0.526 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.357703 | 0.446 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.290479 | 0.537 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.287485 | 0.541 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.331353 | 0.480 |
| R-HSA-3214847 | HATs acetylate histones | 0.343386 | 0.464 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.153627 | 0.814 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.371782 | 0.430 |
| R-HSA-5688426 | Deubiquitination | 0.190051 | 0.721 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.153627 | 0.814 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.140754 | 0.852 |
| R-HSA-70635 | Urea cycle | 0.298178 | 0.526 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.151023 | 0.821 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.183152 | 0.737 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.350546 | 0.455 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.183152 | 0.737 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.191455 | 0.718 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.191455 | 0.718 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.343309 | 0.464 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.350546 | 0.455 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.284493 | 0.546 |
| R-HSA-622312 | Inflammasomes | 0.313554 | 0.504 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.278519 | 0.555 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.161524 | 0.792 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.169542 | 0.771 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.177690 | 0.750 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.351370 | 0.454 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.171397 | 0.766 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.313554 | 0.504 |
| R-HSA-373760 | L1CAM interactions | 0.174950 | 0.757 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.189535 | 0.722 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.180516 | 0.743 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.305908 | 0.514 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.335993 | 0.474 |
| R-HSA-5673000 | RAF activation | 0.364781 | 0.438 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.148339 | 0.829 |
| R-HSA-9018682 | Biosynthesis of maresins | 0.274468 | 0.562 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.169844 | 0.770 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.357703 | 0.446 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.266389 | 0.574 |
| R-HSA-9757110 | Prednisone ADME | 0.313554 | 0.504 |
| R-HSA-6807070 | PTEN Regulation | 0.248872 | 0.604 |
| R-HSA-162582 | Signal Transduction | 0.291485 | 0.535 |
| R-HSA-75893 | TNF signaling | 0.158193 | 0.801 |
| R-HSA-446728 | Cell junction organization | 0.235113 | 0.629 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.371782 | 0.430 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.201536 | 0.696 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.221675 | 0.654 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.357703 | 0.446 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.371449 | 0.430 |
| R-HSA-1500931 | Cell-Cell communication | 0.314909 | 0.502 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.198455 | 0.702 |
| R-HSA-9758941 | Gastrulation | 0.281504 | 0.551 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.233170 | 0.632 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.274468 | 0.562 |
| R-HSA-421270 | Cell-cell junction organization | 0.351766 | 0.454 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.286796 | 0.542 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.165944 | 0.780 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.293475 | 0.532 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.375114 | 0.426 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.136052 | 0.866 |
| R-HSA-9830369 | Kidney development | 0.201536 | 0.696 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.282723 | 0.549 |
| R-HSA-391251 | Protein folding | 0.311170 | 0.507 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.188677 | 0.724 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.292490 | 0.534 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.343309 | 0.464 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.378706 | 0.422 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.378706 | 0.422 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.378706 | 0.422 |
| R-HSA-111933 | Calmodulin induced events | 0.378706 | 0.422 |
| R-HSA-111997 | CaM pathway | 0.378706 | 0.422 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.378706 | 0.422 |
| R-HSA-4641258 | Degradation of DVL | 0.385554 | 0.414 |
| R-HSA-4641257 | Degradation of AXIN | 0.385554 | 0.414 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.385554 | 0.414 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.386479 | 0.413 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.399026 | 0.399 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.399026 | 0.399 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.399026 | 0.399 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.399026 | 0.399 |
| R-HSA-69541 | Stabilization of p53 | 0.399026 | 0.399 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.399026 | 0.399 |
| R-HSA-201556 | Signaling by ALK | 0.399026 | 0.399 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.405652 | 0.392 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.405652 | 0.392 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.405652 | 0.392 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.405652 | 0.392 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.405652 | 0.392 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.405652 | 0.392 |
| R-HSA-5617833 | Cilium Assembly | 0.407213 | 0.390 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.410159 | 0.387 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.412205 | 0.385 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.412205 | 0.385 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 0.412205 | 0.385 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.412205 | 0.385 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.412205 | 0.385 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.412205 | 0.385 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.412205 | 0.385 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.412205 | 0.385 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.412205 | 0.385 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.417244 | 0.380 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.418686 | 0.378 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.418686 | 0.378 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.418686 | 0.378 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.418686 | 0.378 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.418686 | 0.378 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.418686 | 0.378 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.418686 | 0.378 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.425096 | 0.372 |
| R-HSA-111996 | Ca-dependent events | 0.425096 | 0.372 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.431435 | 0.365 |
| R-HSA-9907900 | Proteasome assembly | 0.437706 | 0.359 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.437706 | 0.359 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.443907 | 0.353 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.443907 | 0.353 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.443907 | 0.353 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.443907 | 0.353 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.443907 | 0.353 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.443907 | 0.353 |
| R-HSA-9824272 | Somitogenesis | 0.443907 | 0.353 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.445935 | 0.351 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.447706 | 0.349 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.450040 | 0.347 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.450040 | 0.347 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.450040 | 0.347 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.450040 | 0.347 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.450040 | 0.347 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.450040 | 0.347 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.450040 | 0.347 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.450040 | 0.347 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.450040 | 0.347 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.450040 | 0.347 |
| R-HSA-75153 | Apoptotic execution phase | 0.450040 | 0.347 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.456107 | 0.341 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.456107 | 0.341 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.456107 | 0.341 |
| R-HSA-437239 | Recycling pathway of L1 | 0.456107 | 0.341 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.460498 | 0.337 |
| R-HSA-5620924 | Intraflagellar transport | 0.462106 | 0.335 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.462913 | 0.335 |
| R-HSA-195721 | Signaling by WNT | 0.467732 | 0.330 |
| R-HSA-9766229 | Degradation of CDH1 | 0.468040 | 0.330 |
| R-HSA-73893 | DNA Damage Bypass | 0.468040 | 0.330 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 0.468040 | 0.330 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.468040 | 0.330 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.468040 | 0.330 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.469654 | 0.328 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.473909 | 0.324 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.473909 | 0.324 |
| R-HSA-8953854 | Metabolism of RNA | 0.474875 | 0.323 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.479713 | 0.319 |
| R-HSA-9864848 | Complex IV assembly | 0.479713 | 0.319 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.479713 | 0.319 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.479713 | 0.319 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.479713 | 0.319 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.485453 | 0.314 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.485453 | 0.314 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.485453 | 0.314 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.485453 | 0.314 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.485453 | 0.314 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.487545 | 0.312 |
| R-HSA-418990 | Adherens junctions interactions | 0.490449 | 0.309 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.491131 | 0.309 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.491131 | 0.309 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.491131 | 0.309 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.491131 | 0.309 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.491131 | 0.309 |
| R-HSA-1221632 | Meiotic synapsis | 0.491131 | 0.309 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.491131 | 0.309 |
| R-HSA-72649 | Translation initiation complex formation | 0.496746 | 0.304 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.496746 | 0.304 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.496746 | 0.304 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.502300 | 0.299 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.502300 | 0.299 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.505057 | 0.297 |
| R-HSA-163685 | Integration of energy metabolism | 0.505057 | 0.297 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.507793 | 0.294 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.507793 | 0.294 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.507793 | 0.294 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.507793 | 0.294 |
| R-HSA-5578775 | Ion homeostasis | 0.507793 | 0.294 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.511953 | 0.291 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.512428 | 0.290 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.513225 | 0.290 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.513225 | 0.290 |
| R-HSA-162906 | HIV Infection | 0.515140 | 0.288 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.517845 | 0.286 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.518598 | 0.285 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.518598 | 0.285 |
| R-HSA-388396 | GPCR downstream signalling | 0.518767 | 0.285 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.523912 | 0.281 |
| R-HSA-180786 | Extension of Telomeres | 0.523912 | 0.281 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.526515 | 0.279 |
| R-HSA-8957322 | Metabolism of steroids | 0.528804 | 0.277 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.528918 | 0.277 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.528918 | 0.277 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.529167 | 0.276 |
| R-HSA-983189 | Kinesins | 0.529167 | 0.276 |
| R-HSA-351202 | Metabolism of polyamines | 0.529167 | 0.276 |
| R-HSA-211976 | Endogenous sterols | 0.534365 | 0.272 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.534365 | 0.272 |
| R-HSA-112043 | PLC beta mediated events | 0.534365 | 0.272 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.535591 | 0.271 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.539506 | 0.268 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.539506 | 0.268 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.539506 | 0.268 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.539506 | 0.268 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.544590 | 0.264 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.544590 | 0.264 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.544590 | 0.264 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.544726 | 0.264 |
| R-HSA-166520 | Signaling by NTRKs | 0.548745 | 0.261 |
| R-HSA-211981 | Xenobiotics | 0.549619 | 0.260 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.554592 | 0.256 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.554592 | 0.256 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.559511 | 0.252 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.559511 | 0.252 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.561636 | 0.251 |
| R-HSA-112040 | G-protein mediated events | 0.564376 | 0.248 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.564376 | 0.248 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.569187 | 0.245 |
| R-HSA-162587 | HIV Life Cycle | 0.577380 | 0.239 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.578651 | 0.238 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.578651 | 0.238 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.578651 | 0.238 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.578651 | 0.238 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.578651 | 0.238 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.579887 | 0.237 |
| R-HSA-9711097 | Cellular response to starvation | 0.580480 | 0.236 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.583306 | 0.234 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.583306 | 0.234 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.583306 | 0.234 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.583306 | 0.234 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.587909 | 0.231 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.587909 | 0.231 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.587909 | 0.231 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.592462 | 0.227 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.592462 | 0.227 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.592462 | 0.227 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.592462 | 0.227 |
| R-HSA-4086398 | Ca2+ pathway | 0.592462 | 0.227 |
| R-HSA-9749641 | Aspirin ADME | 0.592462 | 0.227 |
| R-HSA-109581 | Apoptosis | 0.592710 | 0.227 |
| R-HSA-380287 | Centrosome maturation | 0.601418 | 0.221 |
| R-HSA-8852135 | Protein ubiquitination | 0.601418 | 0.221 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.601418 | 0.221 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.601418 | 0.221 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.605822 | 0.218 |
| R-HSA-73894 | DNA Repair | 0.607338 | 0.217 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.607624 | 0.216 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.614486 | 0.211 |
| R-HSA-5619084 | ABC transporter disorders | 0.614486 | 0.211 |
| R-HSA-4086400 | PCP/CE pathway | 0.614486 | 0.211 |
| R-HSA-9679506 | SARS-CoV Infections | 0.615071 | 0.211 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.619256 | 0.208 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.622123 | 0.206 |
| R-HSA-9833482 | PKR-mediated signaling | 0.622961 | 0.206 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.624973 | 0.204 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.627128 | 0.203 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.627806 | 0.202 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.627806 | 0.202 |
| R-HSA-112316 | Neuronal System | 0.631009 | 0.200 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.631250 | 0.200 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.633423 | 0.198 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.635326 | 0.197 |
| R-HSA-372790 | Signaling by GPCR | 0.638752 | 0.195 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.639358 | 0.194 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.639358 | 0.194 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.641810 | 0.193 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.643345 | 0.192 |
| R-HSA-1500620 | Meiosis | 0.643345 | 0.192 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.643345 | 0.192 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.643345 | 0.192 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.644048 | 0.191 |
| R-HSA-2559583 | Cellular Senescence | 0.647178 | 0.189 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.647289 | 0.189 |
| R-HSA-68886 | M Phase | 0.653162 | 0.185 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.658861 | 0.181 |
| R-HSA-156902 | Peptide chain elongation | 0.658861 | 0.181 |
| R-HSA-9675108 | Nervous system development | 0.658995 | 0.181 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.662634 | 0.179 |
| R-HSA-69275 | G2/M Transition | 0.663144 | 0.178 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.663144 | 0.178 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.666365 | 0.176 |
| R-HSA-73884 | Base Excision Repair | 0.666365 | 0.176 |
| R-HSA-202424 | Downstream TCR signaling | 0.666365 | 0.176 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.668337 | 0.175 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.668337 | 0.175 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.670055 | 0.174 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.670055 | 0.174 |
| R-HSA-983712 | Ion channel transport | 0.670908 | 0.173 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.673705 | 0.172 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.677315 | 0.169 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.680885 | 0.167 |
| R-HSA-68877 | Mitotic Prometaphase | 0.681036 | 0.167 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.683528 | 0.165 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.684415 | 0.165 |
| R-HSA-1474290 | Collagen formation | 0.684415 | 0.165 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.687907 | 0.162 |
| R-HSA-9609690 | HCMV Early Events | 0.688465 | 0.162 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.688465 | 0.162 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.691360 | 0.160 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.691360 | 0.160 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.691360 | 0.160 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.698149 | 0.156 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.698153 | 0.156 |
| R-HSA-157579 | Telomere Maintenance | 0.698153 | 0.156 |
| R-HSA-8978868 | Fatty acid metabolism | 0.698803 | 0.156 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.701494 | 0.154 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.704798 | 0.152 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.704798 | 0.152 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.705249 | 0.152 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.705249 | 0.152 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.708065 | 0.150 |
| R-HSA-72172 | mRNA Splicing | 0.709905 | 0.149 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.711297 | 0.148 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.712558 | 0.147 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.714493 | 0.146 |
| R-HSA-192823 | Viral mRNA Translation | 0.717653 | 0.144 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.720779 | 0.142 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.720779 | 0.142 |
| R-HSA-111885 | Opioid Signalling | 0.720779 | 0.142 |
| R-HSA-9833110 | RSV-host interactions | 0.723871 | 0.140 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.724061 | 0.140 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.726928 | 0.139 |
| R-HSA-9824446 | Viral Infection Pathways | 0.729907 | 0.137 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.732943 | 0.135 |
| R-HSA-69239 | Synthesis of DNA | 0.732943 | 0.135 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.735900 | 0.133 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.735900 | 0.133 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.735900 | 0.133 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.735900 | 0.133 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.738825 | 0.131 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.741718 | 0.130 |
| R-HSA-202403 | TCR signaling | 0.741718 | 0.130 |
| R-HSA-6803157 | Antimicrobial peptides | 0.744579 | 0.128 |
| R-HSA-8951664 | Neddylation | 0.747053 | 0.127 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.747408 | 0.126 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.747408 | 0.126 |
| R-HSA-1280218 | Adaptive Immune System | 0.747997 | 0.126 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.750207 | 0.125 |
| R-HSA-422475 | Axon guidance | 0.752746 | 0.123 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.752974 | 0.123 |
| R-HSA-166663 | Initial triggering of complement | 0.755711 | 0.122 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.755711 | 0.122 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.758418 | 0.120 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.761095 | 0.119 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.763742 | 0.117 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.763742 | 0.117 |
| R-HSA-72312 | rRNA processing | 0.768868 | 0.114 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.768950 | 0.114 |
| R-HSA-5693538 | Homology Directed Repair | 0.768950 | 0.114 |
| R-HSA-3371556 | Cellular response to heat stress | 0.776548 | 0.110 |
| R-HSA-73886 | Chromosome Maintenance | 0.776548 | 0.110 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.776612 | 0.110 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.783898 | 0.106 |
| R-HSA-977606 | Regulation of Complement cascade | 0.786294 | 0.104 |
| R-HSA-69206 | G1/S Transition | 0.788664 | 0.103 |
| R-HSA-69481 | G2/M Checkpoints | 0.793325 | 0.101 |
| R-HSA-9609646 | HCMV Infection | 0.801055 | 0.096 |
| R-HSA-1474165 | Reproduction | 0.802343 | 0.096 |
| R-HSA-5576891 | Cardiac conduction | 0.804536 | 0.094 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.810872 | 0.091 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.817193 | 0.088 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.819222 | 0.087 |
| R-HSA-1640170 | Cell Cycle | 0.820358 | 0.086 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.823212 | 0.084 |
| R-HSA-416476 | G alpha (q) signalling events | 0.823292 | 0.084 |
| R-HSA-913531 | Interferon Signaling | 0.826109 | 0.083 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.832810 | 0.079 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.833210 | 0.079 |
| R-HSA-166658 | Complement cascade | 0.836502 | 0.078 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.838318 | 0.077 |
| R-HSA-597592 | Post-translational protein modification | 0.841213 | 0.075 |
| R-HSA-69242 | S Phase | 0.841889 | 0.075 |
| R-HSA-449147 | Signaling by Interleukins | 0.844949 | 0.073 |
| R-HSA-2142753 | Arachidonate metabolism | 0.848799 | 0.071 |
| R-HSA-9609507 | Protein localization | 0.850478 | 0.070 |
| R-HSA-69306 | DNA Replication | 0.850478 | 0.070 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.852140 | 0.069 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.853783 | 0.069 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.858603 | 0.066 |
| R-HSA-877300 | Interferon gamma signaling | 0.860175 | 0.065 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.861729 | 0.065 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.867776 | 0.062 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.867776 | 0.062 |
| R-HSA-418555 | G alpha (s) signalling events | 0.879091 | 0.056 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.884382 | 0.053 |
| R-HSA-611105 | Respiratory electron transport | 0.888199 | 0.051 |
| R-HSA-168249 | Innate Immune System | 0.888277 | 0.051 |
| R-HSA-168255 | Influenza Infection | 0.889443 | 0.051 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.891801 | 0.050 |
| R-HSA-6798695 | Neutrophil degranulation | 0.900769 | 0.045 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.915502 | 0.038 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.915502 | 0.038 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.922272 | 0.035 |
| R-HSA-397014 | Muscle contraction | 0.924464 | 0.034 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.925306 | 0.034 |
| R-HSA-68882 | Mitotic Anaphase | 0.927778 | 0.033 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.928584 | 0.032 |
| R-HSA-9748784 | Drug ADME | 0.929381 | 0.032 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.937582 | 0.028 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.938279 | 0.028 |
| R-HSA-211859 | Biological oxidations | 0.941620 | 0.026 |
| R-HSA-8939211 | ESR-mediated signaling | 0.942946 | 0.026 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.945279 | 0.024 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.949010 | 0.023 |
| R-HSA-418594 | G alpha (i) signalling events | 0.951533 | 0.022 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.954942 | 0.020 |
| R-HSA-168256 | Immune System | 0.955631 | 0.020 |
| R-HSA-72766 | Translation | 0.960598 | 0.017 |
| R-HSA-392499 | Metabolism of proteins | 0.964960 | 0.015 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.965219 | 0.015 |
| R-HSA-9658195 | Leishmania infection | 0.965219 | 0.015 |
| R-HSA-1483257 | Phospholipid metabolism | 0.970296 | 0.013 |
| R-HSA-5663205 | Infectious disease | 0.971062 | 0.013 |
| R-HSA-556833 | Metabolism of lipids | 0.974749 | 0.011 |
| R-HSA-1474244 | Extracellular matrix organization | 0.980215 | 0.009 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.982329 | 0.008 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.986378 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.989969 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 0.991716 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 0.996195 | 0.002 |
| R-HSA-1643685 | Disease | 0.999669 | 0.000 |
| R-HSA-109582 | Hemostasis | 0.999891 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999998 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK19 |
0.844 | 0.803 | 1 | 0.791 |
CDK18 |
0.843 | 0.813 | 1 | 0.808 |
CDK17 |
0.842 | 0.833 | 1 | 0.842 |
HIPK2 |
0.841 | 0.751 | 1 | 0.795 |
P38G |
0.841 | 0.853 | 1 | 0.852 |
CDK8 |
0.839 | 0.806 | 1 | 0.753 |
JNK2 |
0.839 | 0.863 | 1 | 0.807 |
CDK7 |
0.837 | 0.799 | 1 | 0.757 |
KIS |
0.836 | 0.721 | 1 | 0.729 |
CDK13 |
0.835 | 0.811 | 1 | 0.781 |
ERK1 |
0.835 | 0.815 | 1 | 0.790 |
CDK12 |
0.834 | 0.814 | 1 | 0.805 |
CDK16 |
0.834 | 0.797 | 1 | 0.828 |
CDK3 |
0.831 | 0.720 | 1 | 0.834 |
CDK9 |
0.831 | 0.806 | 1 | 0.774 |
P38D |
0.831 | 0.827 | 1 | 0.849 |
DYRK2 |
0.830 | 0.748 | 1 | 0.702 |
CDK1 |
0.830 | 0.786 | 1 | 0.785 |
CDK5 |
0.830 | 0.775 | 1 | 0.726 |
CDK10 |
0.828 | 0.753 | 1 | 0.784 |
DYRK1B |
0.828 | 0.745 | 1 | 0.755 |
JNK3 |
0.828 | 0.848 | 1 | 0.775 |
DYRK4 |
0.827 | 0.754 | 1 | 0.803 |
P38B |
0.827 | 0.809 | 1 | 0.772 |
CDK14 |
0.826 | 0.796 | 1 | 0.766 |
HIPK1 |
0.824 | 0.700 | 1 | 0.681 |
ERK2 |
0.823 | 0.821 | 1 | 0.736 |
P38A |
0.820 | 0.791 | 1 | 0.697 |
CDK4 |
0.818 | 0.791 | 1 | 0.815 |
DYRK1A |
0.815 | 0.618 | 1 | 0.657 |
HIPK4 |
0.815 | 0.477 | 1 | 0.477 |
CDK6 |
0.814 | 0.763 | 1 | 0.786 |
HIPK3 |
0.814 | 0.676 | 1 | 0.653 |
NLK |
0.813 | 0.735 | 1 | 0.476 |
CLK3 |
0.811 | 0.461 | 1 | 0.435 |
JNK1 |
0.808 | 0.761 | 1 | 0.807 |
DYRK3 |
0.807 | 0.563 | 1 | 0.644 |
CLK1 |
0.806 | 0.425 | -3 | 0.706 |
SRPK1 |
0.805 | 0.332 | -3 | 0.698 |
CDK2 |
0.804 | 0.613 | 1 | 0.654 |
ERK5 |
0.800 | 0.406 | 1 | 0.388 |
CLK4 |
0.799 | 0.387 | -3 | 0.723 |
CLK2 |
0.797 | 0.401 | -3 | 0.699 |
MAK |
0.794 | 0.496 | -2 | 0.762 |
MTOR |
0.794 | 0.246 | 1 | 0.267 |
ICK |
0.793 | 0.362 | -3 | 0.785 |
SRPK2 |
0.792 | 0.258 | -3 | 0.631 |
MOK |
0.791 | 0.486 | 1 | 0.565 |
CDKL5 |
0.789 | 0.170 | -3 | 0.748 |
CDKL1 |
0.782 | 0.142 | -3 | 0.758 |
COT |
0.781 | -0.082 | 2 | 0.782 |
SRPK3 |
0.779 | 0.223 | -3 | 0.680 |
PRKD1 |
0.778 | 0.014 | -3 | 0.769 |
CDC7 |
0.778 | -0.080 | 1 | 0.088 |
PRKD2 |
0.778 | 0.033 | -3 | 0.720 |
TBK1 |
0.776 | -0.129 | 1 | 0.064 |
MST4 |
0.774 | -0.020 | 2 | 0.775 |
WNK1 |
0.773 | -0.031 | -2 | 0.891 |
NDR2 |
0.773 | -0.029 | -3 | 0.770 |
NUAK2 |
0.773 | 0.028 | -3 | 0.792 |
GCN2 |
0.772 | -0.165 | 2 | 0.727 |
PRPK |
0.772 | -0.085 | -1 | 0.836 |
PRP4 |
0.772 | 0.417 | -3 | 0.698 |
CAMK1B |
0.772 | -0.006 | -3 | 0.823 |
MOS |
0.772 | -0.040 | 1 | 0.131 |
ERK7 |
0.772 | 0.254 | 2 | 0.480 |
PDHK4 |
0.772 | -0.108 | 1 | 0.143 |
IKKE |
0.771 | -0.146 | 1 | 0.065 |
P90RSK |
0.771 | 0.011 | -3 | 0.723 |
PKN3 |
0.771 | -0.038 | -3 | 0.773 |
RAF1 |
0.770 | -0.154 | 1 | 0.078 |
NDR1 |
0.770 | -0.036 | -3 | 0.776 |
RSK2 |
0.769 | 0.004 | -3 | 0.724 |
NEK6 |
0.769 | -0.068 | -2 | 0.832 |
ULK2 |
0.769 | -0.155 | 2 | 0.726 |
PDHK1 |
0.769 | -0.116 | 1 | 0.123 |
MARK4 |
0.769 | -0.014 | 4 | 0.836 |
TSSK1 |
0.768 | 0.011 | -3 | 0.818 |
PKCD |
0.768 | -0.020 | 2 | 0.714 |
PIM3 |
0.768 | -0.053 | -3 | 0.772 |
ATR |
0.768 | -0.058 | 1 | 0.130 |
CHAK2 |
0.767 | -0.031 | -1 | 0.872 |
AURC |
0.767 | 0.028 | -2 | 0.682 |
RSK3 |
0.767 | -0.014 | -3 | 0.722 |
MAPKAPK3 |
0.767 | -0.034 | -3 | 0.728 |
NIK |
0.767 | -0.030 | -3 | 0.839 |
MNK2 |
0.766 | 0.001 | -2 | 0.808 |
RIPK3 |
0.766 | -0.097 | 3 | 0.814 |
PIM1 |
0.766 | 0.014 | -3 | 0.732 |
PRKD3 |
0.765 | 0.015 | -3 | 0.706 |
PKN2 |
0.765 | -0.056 | -3 | 0.792 |
DSTYK |
0.765 | -0.141 | 2 | 0.760 |
AMPKA1 |
0.765 | -0.028 | -3 | 0.802 |
SKMLCK |
0.765 | -0.038 | -2 | 0.871 |
NEK7 |
0.765 | -0.139 | -3 | 0.831 |
BMPR2 |
0.764 | -0.167 | -2 | 0.853 |
CAMLCK |
0.764 | -0.001 | -2 | 0.840 |
NIM1 |
0.764 | -0.032 | 3 | 0.843 |
NUAK1 |
0.764 | -0.006 | -3 | 0.746 |
AMPKA2 |
0.764 | -0.008 | -3 | 0.769 |
P70S6KB |
0.764 | -0.000 | -3 | 0.754 |
PKACG |
0.763 | -0.014 | -2 | 0.764 |
IKKB |
0.763 | -0.177 | -2 | 0.732 |
LATS2 |
0.763 | -0.036 | -5 | 0.756 |
IRE1 |
0.763 | -0.069 | 1 | 0.079 |
TGFBR2 |
0.762 | -0.102 | -2 | 0.767 |
TSSK2 |
0.762 | -0.030 | -5 | 0.865 |
WNK3 |
0.762 | -0.134 | 1 | 0.079 |
MAPKAPK2 |
0.762 | -0.021 | -3 | 0.677 |
DAPK2 |
0.762 | -0.019 | -3 | 0.825 |
CAMK2D |
0.761 | -0.072 | -3 | 0.800 |
ULK1 |
0.761 | -0.140 | -3 | 0.799 |
MELK |
0.761 | -0.029 | -3 | 0.760 |
CAMK2G |
0.761 | -0.098 | 2 | 0.714 |
MNK1 |
0.760 | 0.007 | -2 | 0.812 |
QSK |
0.759 | 0.000 | 4 | 0.811 |
PKCB |
0.759 | -0.028 | 2 | 0.659 |
NEK9 |
0.759 | -0.144 | 2 | 0.754 |
BCKDK |
0.759 | -0.137 | -1 | 0.797 |
AURB |
0.759 | 0.010 | -2 | 0.676 |
PAK3 |
0.759 | -0.045 | -2 | 0.775 |
HUNK |
0.759 | -0.131 | 2 | 0.684 |
PHKG1 |
0.758 | -0.062 | -3 | 0.776 |
QIK |
0.757 | -0.046 | -3 | 0.795 |
CAMK4 |
0.757 | -0.079 | -3 | 0.778 |
RIPK1 |
0.757 | -0.141 | 1 | 0.068 |
IRE2 |
0.757 | -0.064 | 2 | 0.721 |
MLK1 |
0.757 | -0.162 | 2 | 0.730 |
PAK1 |
0.756 | -0.035 | -2 | 0.780 |
PKCZ |
0.756 | -0.038 | 2 | 0.704 |
SGK3 |
0.756 | 0.010 | -3 | 0.708 |
MLK2 |
0.756 | -0.122 | 2 | 0.745 |
DNAPK |
0.756 | -0.035 | 1 | 0.134 |
MASTL |
0.756 | -0.146 | -2 | 0.803 |
ATM |
0.755 | -0.070 | 1 | 0.101 |
PKCG |
0.755 | -0.045 | 2 | 0.654 |
PKCA |
0.755 | -0.037 | 2 | 0.654 |
PKACB |
0.754 | 0.016 | -2 | 0.700 |
AKT2 |
0.754 | 0.026 | -3 | 0.648 |
PINK1 |
0.754 | 0.167 | 1 | 0.296 |
BRSK2 |
0.754 | -0.053 | -3 | 0.772 |
GSK3A |
0.754 | 0.224 | 4 | 0.534 |
MSK2 |
0.754 | -0.040 | -3 | 0.697 |
VRK2 |
0.754 | 0.108 | 1 | 0.179 |
PAK6 |
0.753 | -0.022 | -2 | 0.705 |
NEK2 |
0.753 | -0.099 | 2 | 0.734 |
PKG2 |
0.753 | -0.003 | -2 | 0.703 |
PKCH |
0.753 | -0.056 | 2 | 0.652 |
RSK4 |
0.752 | -0.004 | -3 | 0.682 |
LATS1 |
0.752 | -0.003 | -3 | 0.777 |
ANKRD3 |
0.752 | -0.145 | 1 | 0.091 |
SIK |
0.752 | -0.028 | -3 | 0.718 |
PKR |
0.752 | -0.073 | 1 | 0.097 |
CHAK1 |
0.752 | -0.108 | 2 | 0.707 |
GRK5 |
0.752 | -0.170 | -3 | 0.809 |
SMG1 |
0.751 | -0.059 | 1 | 0.120 |
MARK3 |
0.751 | -0.007 | 4 | 0.785 |
IKKA |
0.751 | -0.122 | -2 | 0.723 |
BRSK1 |
0.751 | -0.044 | -3 | 0.744 |
MLK3 |
0.751 | -0.090 | 2 | 0.660 |
ALK4 |
0.750 | -0.060 | -2 | 0.802 |
MSK1 |
0.750 | -0.018 | -3 | 0.700 |
MPSK1 |
0.749 | 0.033 | 1 | 0.151 |
DCAMKL1 |
0.749 | -0.018 | -3 | 0.733 |
GRK1 |
0.749 | -0.074 | -2 | 0.759 |
MAPKAPK5 |
0.749 | -0.070 | -3 | 0.692 |
CAMK2B |
0.749 | -0.058 | 2 | 0.684 |
CAMK1G |
0.749 | -0.034 | -3 | 0.728 |
AKT1 |
0.748 | 0.016 | -3 | 0.661 |
CAMK2A |
0.748 | -0.029 | 2 | 0.690 |
MARK2 |
0.748 | -0.020 | 4 | 0.743 |
WNK4 |
0.748 | -0.053 | -2 | 0.873 |
SNRK |
0.748 | -0.105 | 2 | 0.645 |
BMPR1B |
0.748 | -0.064 | 1 | 0.061 |
PAK2 |
0.748 | -0.056 | -2 | 0.765 |
PKCT |
0.748 | -0.044 | 2 | 0.667 |
CHK1 |
0.748 | -0.048 | -3 | 0.782 |
SSTK |
0.748 | 0.002 | 4 | 0.786 |
PRKX |
0.747 | 0.028 | -3 | 0.617 |
DLK |
0.747 | -0.221 | 1 | 0.087 |
GRK6 |
0.747 | -0.137 | 1 | 0.073 |
PIM2 |
0.747 | 0.008 | -3 | 0.704 |
MYLK4 |
0.746 | -0.034 | -2 | 0.779 |
PHKG2 |
0.746 | -0.063 | -3 | 0.760 |
PLK1 |
0.746 | -0.117 | -2 | 0.763 |
TGFBR1 |
0.746 | -0.067 | -2 | 0.779 |
MEK1 |
0.745 | -0.124 | 2 | 0.749 |
YSK4 |
0.745 | -0.165 | 1 | 0.066 |
IRAK4 |
0.745 | -0.084 | 1 | 0.060 |
TTBK2 |
0.744 | -0.198 | 2 | 0.604 |
PKCI |
0.744 | -0.025 | 2 | 0.676 |
MARK1 |
0.743 | -0.044 | 4 | 0.800 |
FAM20C |
0.742 | -0.038 | 2 | 0.513 |
DCAMKL2 |
0.742 | -0.038 | -3 | 0.766 |
PLK4 |
0.742 | -0.117 | 2 | 0.590 |
P70S6K |
0.742 | -0.024 | -3 | 0.674 |
MLK4 |
0.741 | -0.127 | 2 | 0.654 |
HRI |
0.741 | -0.139 | -2 | 0.821 |
GRK7 |
0.741 | -0.044 | 1 | 0.107 |
PERK |
0.741 | -0.133 | -2 | 0.807 |
GSK3B |
0.741 | 0.088 | 4 | 0.526 |
PKACA |
0.741 | 0.002 | -2 | 0.659 |
PKN1 |
0.740 | -0.025 | -3 | 0.692 |
AURA |
0.740 | -0.033 | -2 | 0.640 |
PLK3 |
0.740 | -0.099 | 2 | 0.668 |
SBK |
0.739 | 0.119 | -3 | 0.537 |
MST3 |
0.739 | -0.062 | 2 | 0.730 |
NEK5 |
0.739 | -0.106 | 1 | 0.073 |
TLK2 |
0.739 | -0.136 | 1 | 0.073 |
ZAK |
0.739 | -0.141 | 1 | 0.073 |
PKCE |
0.738 | -0.009 | 2 | 0.639 |
MEK5 |
0.738 | -0.140 | 2 | 0.750 |
MEKK1 |
0.738 | -0.145 | 1 | 0.088 |
ALK2 |
0.738 | -0.090 | -2 | 0.777 |
CAMK1D |
0.737 | -0.018 | -3 | 0.647 |
PAK5 |
0.737 | -0.043 | -2 | 0.648 |
SMMLCK |
0.737 | -0.028 | -3 | 0.779 |
AKT3 |
0.737 | 0.018 | -3 | 0.580 |
GRK4 |
0.736 | -0.197 | -2 | 0.784 |
ACVR2A |
0.736 | -0.119 | -2 | 0.755 |
ACVR2B |
0.736 | -0.120 | -2 | 0.764 |
MEKK2 |
0.735 | -0.119 | 2 | 0.733 |
TAO3 |
0.735 | -0.070 | 1 | 0.111 |
SGK1 |
0.735 | 0.038 | -3 | 0.566 |
DRAK1 |
0.735 | -0.154 | 1 | 0.052 |
TLK1 |
0.734 | -0.130 | -2 | 0.792 |
PAK4 |
0.733 | -0.038 | -2 | 0.656 |
BMPR1A |
0.732 | -0.074 | 1 | 0.052 |
LKB1 |
0.732 | -0.031 | -3 | 0.806 |
NEK4 |
0.732 | -0.098 | 1 | 0.067 |
CAMK1A |
0.732 | -0.002 | -3 | 0.613 |
NEK11 |
0.731 | -0.122 | 1 | 0.105 |
GRK2 |
0.731 | -0.100 | -2 | 0.681 |
BRAF |
0.731 | -0.133 | -4 | 0.775 |
MRCKA |
0.731 | 0.011 | -3 | 0.707 |
MEKK3 |
0.731 | -0.177 | 1 | 0.084 |
PDK1 |
0.730 | -0.065 | 1 | 0.118 |
CHK2 |
0.730 | -0.015 | -3 | 0.600 |
HASPIN |
0.730 | 0.043 | -1 | 0.746 |
BUB1 |
0.729 | 0.015 | -5 | 0.814 |
MRCKB |
0.729 | 0.007 | -3 | 0.694 |
TAO2 |
0.729 | -0.076 | 2 | 0.759 |
CK1E |
0.729 | -0.045 | -3 | 0.530 |
GAK |
0.729 | -0.041 | 1 | 0.131 |
HGK |
0.728 | -0.073 | 3 | 0.887 |
MEKK6 |
0.728 | -0.091 | 1 | 0.087 |
NEK8 |
0.727 | -0.144 | 2 | 0.741 |
MAP3K15 |
0.727 | -0.093 | 1 | 0.088 |
LOK |
0.727 | -0.067 | -2 | 0.773 |
TNIK |
0.726 | -0.056 | 3 | 0.883 |
ROCK2 |
0.726 | 0.003 | -3 | 0.731 |
DAPK3 |
0.726 | -0.032 | -3 | 0.749 |
PBK |
0.725 | -0.027 | 1 | 0.118 |
LRRK2 |
0.725 | -0.014 | 2 | 0.759 |
NEK1 |
0.724 | -0.098 | 1 | 0.059 |
TTBK1 |
0.724 | -0.161 | 2 | 0.534 |
KHS1 |
0.724 | -0.051 | 1 | 0.089 |
CAMKK2 |
0.724 | -0.113 | -2 | 0.763 |
IRAK1 |
0.724 | -0.192 | -1 | 0.762 |
GCK |
0.724 | -0.103 | 1 | 0.092 |
PASK |
0.724 | -0.084 | -3 | 0.790 |
MINK |
0.723 | -0.117 | 1 | 0.068 |
NEK3 |
0.723 | -0.074 | 1 | 0.091 |
HPK1 |
0.722 | -0.088 | 1 | 0.095 |
CAMKK1 |
0.722 | -0.169 | -2 | 0.751 |
PKG1 |
0.722 | -0.021 | -2 | 0.613 |
MST2 |
0.721 | -0.129 | 1 | 0.074 |
RIPK2 |
0.721 | -0.156 | 1 | 0.060 |
VRK1 |
0.721 | -0.109 | 2 | 0.758 |
KHS2 |
0.721 | -0.037 | 1 | 0.101 |
DAPK1 |
0.720 | -0.034 | -3 | 0.736 |
CK1G1 |
0.720 | -0.082 | -3 | 0.505 |
BIKE |
0.720 | -0.009 | 1 | 0.131 |
YSK1 |
0.719 | -0.105 | 2 | 0.730 |
DMPK1 |
0.719 | 0.030 | -3 | 0.713 |
EEF2K |
0.718 | -0.098 | 3 | 0.838 |
CK1D |
0.718 | -0.032 | -3 | 0.475 |
AAK1 |
0.717 | 0.020 | 1 | 0.147 |
ROCK1 |
0.717 | 0.000 | -3 | 0.707 |
CRIK |
0.717 | 0.016 | -3 | 0.651 |
STK33 |
0.717 | -0.117 | 2 | 0.540 |
SLK |
0.716 | -0.090 | -2 | 0.723 |
MST1 |
0.716 | -0.133 | 1 | 0.066 |
MEK2 |
0.716 | -0.146 | 2 | 0.743 |
CK1A2 |
0.714 | -0.053 | -3 | 0.478 |
PLK2 |
0.712 | -0.048 | -3 | 0.840 |
GRK3 |
0.712 | -0.112 | -2 | 0.636 |
CK2A2 |
0.711 | -0.091 | 1 | 0.052 |
TAK1 |
0.711 | -0.205 | 1 | 0.066 |
PDHK3_TYR |
0.710 | 0.137 | 4 | 0.875 |
TAO1 |
0.708 | -0.086 | 1 | 0.087 |
LIMK2_TYR |
0.707 | 0.128 | -3 | 0.845 |
MYO3B |
0.706 | -0.077 | 2 | 0.752 |
ASK1 |
0.705 | -0.107 | 1 | 0.088 |
OSR1 |
0.704 | -0.098 | 2 | 0.734 |
CK2A1 |
0.704 | -0.093 | 1 | 0.046 |
PKMYT1_TYR |
0.703 | 0.120 | 3 | 0.890 |
TESK1_TYR |
0.702 | 0.024 | 3 | 0.904 |
TTK |
0.702 | -0.090 | -2 | 0.791 |
PDHK4_TYR |
0.700 | 0.032 | 2 | 0.797 |
MYO3A |
0.699 | -0.105 | 1 | 0.090 |
MAP2K4_TYR |
0.697 | -0.009 | -1 | 0.860 |
MAP2K7_TYR |
0.696 | -0.078 | 2 | 0.770 |
NEK10_TYR |
0.696 | -0.061 | 1 | 0.095 |
LIMK1_TYR |
0.694 | 0.011 | 2 | 0.775 |
RET |
0.694 | -0.100 | 1 | 0.104 |
MAP2K6_TYR |
0.694 | -0.017 | -1 | 0.856 |
PINK1_TYR |
0.694 | -0.120 | 1 | 0.132 |
MST1R |
0.692 | -0.075 | 3 | 0.861 |
JAK2 |
0.691 | -0.094 | 1 | 0.113 |
TYK2 |
0.691 | -0.154 | 1 | 0.091 |
ROS1 |
0.690 | -0.086 | 3 | 0.857 |
BMPR2_TYR |
0.690 | -0.026 | -1 | 0.834 |
ALPHAK3 |
0.690 | -0.107 | -1 | 0.751 |
STLK3 |
0.689 | -0.159 | 1 | 0.061 |
TNK1 |
0.689 | -0.024 | 3 | 0.862 |
TNNI3K_TYR |
0.689 | -0.030 | 1 | 0.119 |
PDHK1_TYR |
0.689 | -0.092 | -1 | 0.860 |
CSF1R |
0.687 | -0.080 | 3 | 0.857 |
YANK3 |
0.687 | -0.077 | 2 | 0.338 |
TYRO3 |
0.686 | -0.128 | 3 | 0.868 |
DDR1 |
0.686 | -0.087 | 4 | 0.789 |
JAK1 |
0.685 | -0.077 | 1 | 0.089 |
JAK3 |
0.685 | -0.098 | 1 | 0.096 |
YES1 |
0.685 | -0.069 | -1 | 0.831 |
FGFR2 |
0.683 | -0.028 | 3 | 0.834 |
FGFR1 |
0.682 | -0.018 | 3 | 0.822 |
EPHA6 |
0.682 | -0.111 | -1 | 0.829 |
TEK |
0.681 | 0.006 | 3 | 0.816 |
EPHB4 |
0.681 | -0.126 | -1 | 0.814 |
KDR |
0.680 | -0.062 | 3 | 0.822 |
TXK |
0.680 | -0.095 | 1 | 0.051 |
ABL2 |
0.679 | -0.120 | -1 | 0.785 |
INSRR |
0.679 | -0.110 | 3 | 0.815 |
CK1A |
0.678 | -0.073 | -3 | 0.385 |
DDR2 |
0.678 | -0.006 | 3 | 0.777 |
PDGFRB |
0.678 | -0.166 | 3 | 0.868 |
FGR |
0.678 | -0.161 | 1 | 0.061 |
ABL1 |
0.677 | -0.117 | -1 | 0.783 |
TNK2 |
0.677 | -0.114 | 3 | 0.792 |
HCK |
0.675 | -0.133 | -1 | 0.790 |
FLT3 |
0.675 | -0.154 | 3 | 0.862 |
LCK |
0.675 | -0.105 | -1 | 0.784 |
PDGFRA |
0.675 | -0.161 | 3 | 0.866 |
KIT |
0.675 | -0.124 | 3 | 0.856 |
BLK |
0.674 | -0.089 | -1 | 0.796 |
AXL |
0.673 | -0.140 | 3 | 0.837 |
FER |
0.671 | -0.193 | 1 | 0.071 |
ITK |
0.671 | -0.153 | -1 | 0.764 |
EPHB1 |
0.671 | -0.166 | 1 | 0.053 |
MERTK |
0.670 | -0.134 | 3 | 0.835 |
WEE1_TYR |
0.670 | -0.088 | -1 | 0.720 |
FGFR3 |
0.670 | -0.053 | 3 | 0.808 |
EPHA4 |
0.669 | -0.118 | 2 | 0.652 |
EPHB3 |
0.669 | -0.167 | -1 | 0.792 |
ALK |
0.668 | -0.131 | 3 | 0.783 |
SRMS |
0.668 | -0.184 | 1 | 0.048 |
LTK |
0.668 | -0.130 | 3 | 0.801 |
EPHB2 |
0.668 | -0.149 | -1 | 0.786 |
TEC |
0.667 | -0.136 | -1 | 0.720 |
INSR |
0.667 | -0.124 | 3 | 0.802 |
FLT4 |
0.667 | -0.111 | 3 | 0.820 |
MET |
0.666 | -0.135 | 3 | 0.834 |
BMX |
0.665 | -0.126 | -1 | 0.676 |
ERBB2 |
0.665 | -0.149 | 1 | 0.075 |
FYN |
0.665 | -0.088 | -1 | 0.755 |
EPHA1 |
0.664 | -0.146 | 3 | 0.823 |
FLT1 |
0.664 | -0.132 | -1 | 0.796 |
BTK |
0.664 | -0.197 | -1 | 0.738 |
PTK6 |
0.663 | -0.170 | -1 | 0.706 |
FRK |
0.663 | -0.141 | -1 | 0.792 |
NTRK2 |
0.662 | -0.183 | 3 | 0.812 |
NTRK1 |
0.662 | -0.191 | -1 | 0.790 |
EPHA7 |
0.662 | -0.142 | 2 | 0.663 |
LYN |
0.660 | -0.129 | 3 | 0.802 |
SRC |
0.659 | -0.105 | -1 | 0.770 |
PTK2B |
0.659 | -0.115 | -1 | 0.762 |
EGFR |
0.659 | -0.111 | 1 | 0.055 |
EPHA3 |
0.658 | -0.151 | 2 | 0.639 |
NTRK3 |
0.657 | -0.155 | -1 | 0.733 |
MUSK |
0.657 | -0.128 | 1 | 0.041 |
MATK |
0.655 | -0.115 | -1 | 0.708 |
EPHA5 |
0.653 | -0.152 | 2 | 0.643 |
EPHA8 |
0.653 | -0.136 | -1 | 0.759 |
FGFR4 |
0.652 | -0.112 | -1 | 0.741 |
CK1G3 |
0.652 | -0.086 | -3 | 0.334 |
CSK |
0.652 | -0.149 | 2 | 0.671 |
YANK2 |
0.651 | -0.100 | 2 | 0.351 |
IGF1R |
0.649 | -0.124 | 3 | 0.750 |
PTK2 |
0.646 | -0.088 | -1 | 0.756 |
ERBB4 |
0.646 | -0.103 | 1 | 0.054 |
SYK |
0.642 | -0.115 | -1 | 0.717 |
EPHA2 |
0.641 | -0.149 | -1 | 0.730 |
FES |
0.631 | -0.147 | -1 | 0.663 |
ZAP70 |
0.628 | -0.101 | -1 | 0.641 |
CK1G2 |
0.626 | -0.097 | -3 | 0.427 |