Motif 7 (n=159)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYL1 | ST20-MTHFS | S73 | ochoa | 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) | None |
| A5YM69 | ARHGEF35 | S445 | ochoa | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | None |
| A6NGC4 | TLCD2 | S235 | ochoa | TLC domain-containing protein 2 | Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349). {ECO:0000269|PubMed:30509349}. |
| A8MPP1 | DDX11L8 | S44 | ochoa | Putative ATP-dependent DNA helicase DDX11-like protein 8 (EC 5.6.2.-) (DEAD/H box protein 11-like 8) | Putative DNA helicase. {ECO:0000305}. |
| B2RXF5 | ZBTB42 | S328 | ochoa | Zinc finger and BTB domain-containing protein 42 | Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. {ECO:0000250|UniProtKB:Q811H0}. |
| O14513 | NCKAP5 | S1069 | ochoa | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | None |
| O14513 | NCKAP5 | S1469 | ochoa | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | None |
| O14827 | RASGRF2 | S848 | ochoa | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
| O15034 | RIMBP2 | S832 | ochoa | RIMS-binding protein 2 (RIM-BP2) | Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. {ECO:0000250}. |
| O15056 | SYNJ2 | S838 | ochoa | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
| O15085 | ARHGEF11 | S1480 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15503 | INSIG1 | S238 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
| O43566 | RGS14 | S203 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
| O60269 | GPRIN2 | S142 | ochoa | G protein-regulated inducer of neurite outgrowth 2 (GRIN2) | May be involved in neurite outgrowth. {ECO:0000269|PubMed:10480904}. |
| O60566 | BUB1B | S884 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O60673 | REV3L | S1724 | ochoa | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}. |
| O75170 | PPP6R2 | S771 | ochoa|psp | Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
| O75534 | CSDE1 | S482 | ochoa | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
| O94988 | FAM13A | S597 | ochoa | Protein FAM13A | None |
| O95155 | UBE4B | S1265 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| O95685 | PPP1R3D | S78 | ochoa | Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) | Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. |
| O95985 | TOP3B | S788 | ochoa | DNA topoisomerase 3-beta-1 (EC 5.6.2.1) (DNA topoisomerase III beta-1) | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity. {ECO:0000250}. |
| P15622 | ZNF250 | S134 | ochoa | Zinc finger protein 250 (Zinc finger protein 647) | May be involved in transcriptional regulation. |
| P15622 | ZNF250 | S168 | ochoa | Zinc finger protein 250 (Zinc finger protein 647) | May be involved in transcriptional regulation. |
| P17707 | AMD1 | S298 | ochoa|psp | S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] | Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000250|UniProtKB:P0DMN7}. |
| P19793 | RXRA | S27 | psp | Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha) | Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:16107141, PubMed:17761950, PubMed:18800767, PubMed:19167885, PubMed:28167758, PubMed:37478846). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:37478846, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632). {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:11162439, ECO:0000269|PubMed:11915042, ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:1310260, ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:25417649, ECO:0000269|PubMed:26463675, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:29021580, ECO:0000269|PubMed:30216632, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}. |
| P20827 | EFNA1 | S154 | ochoa | Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form] | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|PubMed:17332925, ECO:0000269|PubMed:18794797}. |
| P21127 | CDK11B | S234 | ochoa|psp | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P24928 | POLR2A | S27 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
| P28324 | ELK4 | S381 | psp | ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}. |
| P28562 | DUSP1 | S296 | psp | Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250|UniProtKB:P28563}. |
| P28749 | RBL1 | S650 | ochoa|psp | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P31629 | HIVEP2 | S1070 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P32456 | GBP2 | S157 | ochoa | Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2) | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:31091448). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:31091448). {ECO:0000250|UniProtKB:Q9Z0E6, ECO:0000269|PubMed:31091448, ECO:0000269|PubMed:8706832}. |
| P35237 | SERPINB6 | S151 | ochoa | Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor) | May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}. |
| P42331 | ARHGAP25 | S362 | ochoa|psp | Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P46821 | MAP1B | S2098 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P47736 | RAP1GAP | S515 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P49903 | SEPHS1 | S342 | ochoa | Selenide, water dikinase 1 (EC 2.7.9.3) (Selenium donor protein 1) (Selenophosphate synthase 1) | Synthesizes selenophosphate from selenide and ATP. {ECO:0000269|PubMed:7665581}. |
| P49914 | MTHFS | S97 | ochoa | 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase) | Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. {ECO:0000269|PubMed:8522195}. |
| P53355 | DAPK1 | S734 | psp | Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; FUNCTION: Isoform 2 cannot induce apoptosis but can induce membrane blebbing. |
| P53621 | COPA | S173 | ochoa | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| P61978 | HNRNPK | S353 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P63010 | AP2B1 | S605 | ochoa | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| P82094 | TMF1 | S102 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q07864 | POLE | S1204 | ochoa | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) | Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). {ECO:0000250|UniProtKB:P21951, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:27573199}. |
| Q08999 | RBL2 | S672 | ochoa|psp | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q12770 | SCAP | S1041 | ochoa | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) | Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}. |
| Q12774 | ARHGEF5 | S445 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q13009 | TIAM1 | S358 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13233 | MAP3K1 | S1043 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q13459 | MYO9B | S717 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13523 | PRP4K | S387 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13905 | RAPGEF1 | S412 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q14160 | SCRIB | S939 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q15052 | ARHGEF6 | S225 | ochoa|psp | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15911 | ZFHX3 | S742 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q16513 | PKN2 | S535 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q4FZB7 | KMT5B | S635 | ochoa | Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q3U8K7, ECO:0000269|PubMed:23720823, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}. |
| Q58WW2 | DCAF6 | S467 | ochoa | DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) | Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
| Q5JVL4 | EFHC1 | S524 | ochoa | EF-hand domain-containing protein 1 (Myoclonin-1) | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Microtubule-associated protein which regulates cell division and neuronal migration during cortical development (PubMed:19734894, PubMed:28370826). Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142). May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581, PubMed:19734894, PubMed:22926142, PubMed:28370826). {ECO:0000269|PubMed:15258581, ECO:0000269|PubMed:19734894, ECO:0000269|PubMed:22926142, ECO:0000269|PubMed:28370826, ECO:0000269|PubMed:36191189}. |
| Q5M775 | SPECC1 | S325 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T011 | SZT2 | S215 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T0N5 | FNBP1L | S501 | ochoa | Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}. |
| Q5THJ4 | VPS13D | S2983 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5THK1 | PRR14L | S582 | ochoa | Protein PRR14L (Proline rich 14-like protein) | None |
| Q5W0Q7 | USPL1 | S200 | ochoa | SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1) | SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}. |
| Q66K14 | TBC1D9B | S741 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q66K64 | DCAF15 | S50 | ochoa | DDB1- and CUL4-associated factor 15 | Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31452512}.; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28302793, PubMed:28437394, PubMed:31452512, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31626998, PubMed:31686031, PubMed:31693891). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31452512, ECO:0000269|PubMed:31626998, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}. |
| Q68CZ2 | TNS3 | S901 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68EM7 | ARHGAP17 | S520 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6AI39 | BICRAL | S980 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. {ECO:0000269|PubMed:29374058}. |
| Q6NYC8 | PPP1R18 | S145 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6P0N0 | MIS18BP1 | S541 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P3S6 | FBXO42 | S429 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6PGN9 | PSRC1 | S122 | ochoa | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
| Q6UB98 | ANKRD12 | S149 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6W2J9 | BCOR | S1410 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZMB5 | TMEM184A | S368 | ochoa | Transmembrane protein 184A | Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity). {ECO:0000250|UniProtKB:Q3UFJ6, ECO:0000250|UniProtKB:Q4QQS1}. |
| Q6ZS81 | WDFY4 | S1847 | ochoa | WD repeat- and FYVE domain-containing protein 4 | Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Also plays a role in B-cell survival through regulation of autophagy. {ECO:0000250|UniProtKB:E9Q2M9}. |
| Q6ZU35 | CRACD | S104 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q70EL4 | USP43 | S226 | ochoa | Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) | May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). {ECO:0000250}. |
| Q711Q0 | CEFIP | S844 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q71SY5 | MED25 | S184 | ochoa | Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. {ECO:0000269|PubMed:14657022, ECO:0000269|PubMed:14983011, ECO:0000269|PubMed:17641689}. |
| Q7Z6I8 | C5orf24 | S121 | ochoa | UPF0461 protein C5orf24 | None |
| Q7Z6J8 | UBE3D | S184 | ochoa | E3 ubiquitin-protein ligase E3D (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase E3D) (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein) | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome (PubMed:15749827). Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site (PubMed:39032490). {ECO:0000269|PubMed:15749827, ECO:0000269|PubMed:39032490}. |
| Q86UP3 | ZFHX4 | S715 | ochoa | Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) | May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}. |
| Q86US8 | SMG6 | S424 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86V15 | CASZ1 | S356 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86V48 | LUZP1 | S394 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86WP2 | GPBP1 | S260 | ochoa | Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein) | Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}. |
| Q86X10 | RALGAPB | S921 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q86XL3 | ANKLE2 | S512 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q86YC2 | PALB2 | S190 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q86YC2 | PALB2 | S781 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q8IVT2 | MISP | S430 | ochoa|psp | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IY63 | AMOTL1 | S322 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8IZD2 | KMT2E | S1002 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8IZQ8 | MYOCD | S347 | ochoa | Myocardin | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8R5I7, ECO:0000269|PubMed:12640126, ECO:0000269|PubMed:31513549}. |
| Q8N1F7 | NUP93 | S364 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N1G0 | ZNF687 | S1211 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8NAP3 | ZBTB38 | S1151 | ochoa | Zinc finger and BTB domain-containing protein 38 | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}. |
| Q8NFC6 | BOD1L1 | S3019 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8TBB5 | KLHDC4 | S222 | ochoa | Kelch domain-containing protein 4 | None |
| Q8TDD2 | SP7 | S76 | psp | Transcription factor Sp7 (Zinc finger protein osterix) | Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). {ECO:0000250|UniProtKB:Q8VI67, ECO:0000269|PubMed:23457570}. |
| Q8TEK3 | DOT1L | S775 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TER5 | ARHGEF40 | S255 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8WYQ5 | DGCR8 | S153 | ochoa|psp | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q92560 | BAP1 | S571 | psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92610 | ZNF592 | S1089 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92771 | DDX12P | S63 | ochoa | Putative ATP-dependent DNA helicase DDX12 (EC 5.6.2.-) (CHL1-related protein 2) (hCHLR2) (DEAD/H box protein 12) | DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity). {ECO:0000250}. |
| Q92870 | APBB2 | S123 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q96A54 | ADIPOR1 | S205 | psp | Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member 1) (Progestin and adipoQ receptor family member I) | Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity). {ECO:0000250|UniProtKB:Q91VH1, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}. |
| Q96F81 | DISP1 | S51 | ochoa | Protein dispatched homolog 1 | Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). {ECO:0000250|UniProtKB:Q3TDN0, ECO:0000269|PubMed:22902404}. |
| Q96FC9 | DDX11 | S44 | ochoa | ATP-dependent DNA helicase DDX11 (EC 5.6.2.3) (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (DNA 5'-3' helicase DDX11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2) | DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:10648783, PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Also shows ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Also cooperates with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Also plays a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:18499658, PubMed:22102414, PubMed:9013641). {ECO:0000250|UniProtKB:Q6AXC6, ECO:0000269|PubMed:10648783, ECO:0000269|PubMed:17105772, ECO:0000269|PubMed:18499658, ECO:0000269|PubMed:20124417, ECO:0000269|PubMed:21854770, ECO:0000269|PubMed:22102414, ECO:0000269|PubMed:23116066, ECO:0000269|PubMed:23797032, ECO:0000269|PubMed:26089203, ECO:0000269|PubMed:26503245, ECO:0000269|PubMed:27477908}.; FUNCTION: (Microbial infection) Required for bovine papillomavirus type 1 regulatory protein E2 loading onto mitotic chromosomes during DNA replication for the viral genome to be maintained and segregated. {ECO:0000269|PubMed:17189189}. |
| Q96I34 | PPP1R16A | S437 | ochoa | Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3) | Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. {ECO:0000250}. |
| Q96JA1 | LRIG1 | S1069 | ochoa | Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) | Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}. |
| Q96JE7 | SEC16B | S167 | ochoa | Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) | Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:21768384, PubMed:22355596). Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes (PubMed:21768384). {ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:21768384, ECO:0000303|PubMed:22355596}. |
| Q96JK9 | MAML3 | S170 | ochoa | Mastermind-like protein 3 (Mam-3) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158}. |
| Q96L73 | NSD1 | S752 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96NU1 | SAMD11 | S171 | ochoa | Sterile alpha motif domain-containing protein 11 (SAM domain-containing protein 11) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells. {ECO:0000250|UniProtKB:Q1RNF8}. |
| Q96QC0 | PPP1R10 | S313 | ochoa | Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}. |
| Q96SF7 | TBX15 | S256 | ochoa | T-box transcription factor TBX15 (T-box protein 15) (T-box transcription factor TBX14) (T-box protein 14) | Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity). {ECO:0000250}. |
| Q99504 | EYA3 | S438 | ochoa | Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}. |
| Q9BQ70 | TCF25 | S602 | ochoa | Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25) | Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (By similarity). {ECO:0000250|UniProtKB:A0A8I6ASZ5, ECO:0000250|UniProtKB:Q8R3L2, ECO:0000269|PubMed:30244831}. |
| Q9BR39 | JPH2 | S508 | ochoa | Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}. |
| Q9BTE3 | MCMBP | S118 | ochoa | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) | Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}. |
| Q9BWT3 | PAPOLG | S599 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BZW8 | CD244 | S334 | ochoa | Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244) | Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:11714776, PubMed:8376943). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:11714776, PubMed:8376943). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). {ECO:0000250|UniProtKB:Q07763, ECO:0000269|PubMed:10359122, ECO:0000269|PubMed:10741393, ECO:0000269|PubMed:10934222, ECO:0000269|PubMed:11714776, ECO:0000269|PubMed:11917118, ECO:0000269|PubMed:8376943, ECO:0000305|PubMed:15713798}. |
| Q9C0A1 | ZFHX2 | S524 | ochoa | Zinc finger homeobox protein 2 (Zinc finger homeodomain protein 2) (ZFH-2) | Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli. {ECO:0000269|PubMed:29253101}. |
| Q9C0A1 | ZFHX2 | S686 | ochoa | Zinc finger homeobox protein 2 (Zinc finger homeodomain protein 2) (ZFH-2) | Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli. {ECO:0000269|PubMed:29253101}. |
| Q9C0D5 | TANC1 | S270 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H7X7 | IFT22 | S137 | ochoa | Intraflagellar transport protein 22 homolog (Rab-like protein 5) | Small GTPase-like component of the intraflagellar transport (IFT) complex B. {ECO:0000250}. |
| Q9H8K7 | PAAT | S201 | ochoa | ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT) | ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). {ECO:0000269|PubMed:25063848}. |
| Q9H8X2 | IPPK | S282 | ochoa | Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase) | Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}. |
| Q9HCN4 | GPN1 | S314 | ochoa | GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1) | Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:21768307, ECO:0000305|PubMed:11058119}. |
| Q9NRI5 | DISC1 | S58 | psp | Disrupted in schizophrenia 1 protein | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19303846, PubMed:19502360). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030). {ECO:0000250|UniProtKB:Q811T9, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:19303846, ECO:0000269|PubMed:19502360}. |
| Q9NYF5 | FAM13B | S501 | ochoa | Protein FAM13B (GAP-like protein N61) | None |
| Q9NZN5 | ARHGEF12 | S824 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P212 | PLCE1 | S1709 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182, ECO:0000269|PubMed:29058690}. |
| Q9P2D3 | HEATR5B | S1737 | ochoa | HEAT repeat-containing protein 5B | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
| Q9UBZ9 | REV1 | S254 | ochoa | DNA repair protein REV1 (EC 2.7.7.-) (Alpha integrin-binding protein 80) (AIBP80) (Rev1-like terminal deoxycytidyl transferase) | Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. {ECO:0000269|PubMed:10536157, ECO:0000269|PubMed:10760286, ECO:0000269|PubMed:11278384, ECO:0000269|PubMed:11485998, ECO:0000269|PubMed:22266823}. |
| Q9UGU5 | HMGXB4 | S197 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
| Q9UH62 | ARMCX3 | S119 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UHV7 | MED13 | S749 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Q9UIF8 | BAZ2B | S533 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9ULU4 | ZMYND8 | S406 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UNY4 | TTF2 | S883 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPG8 | PLAGL2 | S273 | ochoa | Zinc finger protein PLAGL2 (Pleiomorphic adenoma-like protein 2) | Shows weak transcriptional activatory activity. |
| Q9UPN9 | TRIM33 | S959 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9UQ88 | CDK11A | S222 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y2F5 | ICE1 | S1838 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y3E2 | BOLA1 | S45 | ochoa | BolA-like protein 1 (hBolA) | Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225). {ECO:0000250|UniProtKB:Q3E793, ECO:0000269|PubMed:22746225, ECO:0000305|PubMed:27532772}. |
| Q9Y490 | TLN1 | S979 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4Z2 | NEUROG3 | S183 | psp | Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5) | Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). {ECO:0000250}. |
| Q16595 | FXN | S158 | Sugiyama | Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN); Frataxin(56-210) (m56-FXN); Frataxin(78-210) (d-FXN) (m78-FXN); Frataxin mature form (Frataxin(81-210)) (m81-FXN); Extramitochondrial frataxin] | [Frataxin mature form]: Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly (PubMed:12785837, PubMed:24971490). Accelerates sulfur transfer from NFS1 persulfide intermediate to ISCU and to small thiols such as L-cysteine and glutathione leading to persulfuration of these thiols and ultimately sulfide release (PubMed:24971490). Binds ferrous ion and is released from FXN upon the addition of both L-cysteine and reduced FDX2 during [2Fe-2S] cluster assembly (PubMed:29576242). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity (PubMed:15641778). May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems (PubMed:11823441, PubMed:12755598). May function as an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation (PubMed:15247478). May play a role as a high affinity iron binding partner for FECH that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis (PubMed:15123683, PubMed:16239244). {ECO:0000250|UniProtKB:Q9H1K1, ECO:0000269|PubMed:11823441, ECO:0000269|PubMed:12755598, ECO:0000269|PubMed:12785837, ECO:0000269|PubMed:15123683, ECO:0000269|PubMed:15247478, ECO:0000269|PubMed:15641778, ECO:0000269|PubMed:16239244, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242}.; FUNCTION: [Extramitochondrial frataxin]: Modulates the RNA-binding activity of ACO1 (PubMed:20053667). May be involved in the cytoplasmic iron-sulfur protein biogenesis (PubMed:16091420). May contribute to oxidative stress resistance and overall cell survival (PubMed:16608849). {ECO:0000269|PubMed:16091420, ECO:0000269|PubMed:16608849, ECO:0000269|PubMed:20053667}. |
| Q8TEW0 | PARD3 | S728 | Sugiyama | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| P41970 | ELK3 | S357 | ELM|iPTMNet | ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) | May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. |
| P08151 | GLI1 | S602 | GPS6 | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-193648 | NRAGE signals death through JNK | 5.380920e-07 | 6.269 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.042107e-06 | 5.517 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.697316e-06 | 5.328 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.715387e-05 | 4.566 |
| R-HSA-73887 | Death Receptor Signaling | 5.585802e-04 | 3.253 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.342492e-03 | 2.872 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 1.828450e-03 | 2.738 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.522526e-03 | 2.598 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 3.392763e-03 | 2.469 |
| R-HSA-73893 | DNA Damage Bypass | 3.378483e-03 | 2.471 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 6.408184e-03 | 2.193 |
| R-HSA-1538133 | G0 and Early G1 | 8.014376e-03 | 2.096 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.496177e-02 | 1.825 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.773513e-02 | 1.751 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.951634e-02 | 1.710 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.951634e-02 | 1.710 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.136933e-02 | 1.670 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.133885e-02 | 1.671 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.136933e-02 | 1.670 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.916673e-02 | 1.717 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 8.146404e-02 | 1.089 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 8.146404e-02 | 1.089 |
| R-HSA-210746 | Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells | 9.117159e-02 | 1.040 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 1.007771e-01 | 0.997 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 1.007771e-01 | 0.997 |
| R-HSA-9031525 | NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | 1.007771e-01 | 0.997 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.390142e-02 | 1.470 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.473118e-01 | 0.832 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.563273e-01 | 0.806 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.652481e-01 | 0.782 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.652481e-01 | 0.782 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.740751e-01 | 0.759 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.828093e-01 | 0.738 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.828093e-01 | 0.738 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.914516e-01 | 0.718 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 2.000031e-01 | 0.699 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.000031e-01 | 0.699 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.084647e-01 | 0.681 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.168373e-01 | 0.664 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.251218e-01 | 0.648 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.251218e-01 | 0.648 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.333192e-01 | 0.632 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.333192e-01 | 0.632 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.333192e-01 | 0.632 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.333192e-01 | 0.632 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.414304e-01 | 0.617 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.494563e-01 | 0.603 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.494563e-01 | 0.603 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.573977e-01 | 0.589 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.652557e-01 | 0.576 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.652557e-01 | 0.576 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.807243e-01 | 0.552 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.485336e-01 | 0.828 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.558906e-01 | 0.807 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.958692e-01 | 0.529 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.958692e-01 | 0.529 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 3.033223e-01 | 0.518 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.033223e-01 | 0.518 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 3.033223e-01 | 0.518 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.033223e-01 | 0.518 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.179941e-01 | 0.498 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.252144e-01 | 0.488 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.252144e-01 | 0.488 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.394277e-01 | 0.469 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.394277e-01 | 0.469 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.464224e-01 | 0.460 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.206021e-01 | 0.656 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.601916e-01 | 0.443 |
| R-HSA-1989781 | PPARA activates gene expression | 1.137065e-01 | 0.944 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.868707e-01 | 0.412 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.933658e-01 | 0.405 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.933658e-01 | 0.405 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 4.061515e-01 | 0.391 |
| R-HSA-167161 | HIV Transcription Initiation | 4.061515e-01 | 0.391 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 4.061515e-01 | 0.391 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.172187e-01 | 0.931 |
| R-HSA-167169 | HIV Transcription Elongation | 3.933658e-01 | 0.405 |
| R-HSA-72086 | mRNA Capping | 3.106970e-01 | 0.508 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.179941e-01 | 0.498 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.942897e-01 | 0.404 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.414304e-01 | 0.617 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.933658e-01 | 0.405 |
| R-HSA-354192 | Integrin signaling | 3.394277e-01 | 0.469 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.061515e-01 | 0.391 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.922994e-01 | 0.406 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.868707e-01 | 0.412 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.958692e-01 | 0.529 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.801535e-02 | 1.553 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.674937e-01 | 0.573 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.563273e-01 | 0.806 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.000031e-01 | 0.699 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.128438e-01 | 0.672 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.533434e-01 | 0.452 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.736724e-01 | 0.428 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.061515e-01 | 0.391 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.449454e-01 | 0.611 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.491422e-01 | 0.457 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.491422e-01 | 0.457 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.464224e-01 | 0.460 |
| R-HSA-9843745 | Adipogenesis | 7.265238e-02 | 1.139 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 1.007771e-01 | 0.997 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.933658e-01 | 0.405 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.394277e-01 | 0.469 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.494563e-01 | 0.603 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.061515e-01 | 0.391 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.529707e-01 | 0.452 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.762293e-01 | 0.559 |
| R-HSA-8875513 | MET interacts with TNS proteins | 5.171856e-02 | 1.286 |
| R-HSA-8964540 | Alanine metabolism | 6.173862e-02 | 1.209 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.007771e-01 | 0.997 |
| R-HSA-68952 | DNA replication initiation | 1.289924e-01 | 0.889 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.289924e-01 | 0.889 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.563273e-01 | 0.806 |
| R-HSA-9956593 | Microbial factors inhibit CASP4 activity | 1.652481e-01 | 0.782 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 2.251218e-01 | 0.648 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.573977e-01 | 0.589 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.730309e-01 | 0.564 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.730309e-01 | 0.564 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.670520e-01 | 0.777 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.736724e-01 | 0.428 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.897554e-01 | 0.722 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.533434e-01 | 0.452 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 1.289924e-01 | 0.889 |
| R-HSA-9620244 | Long-term potentiation | 2.807243e-01 | 0.552 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.933658e-01 | 0.405 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.933658e-01 | 0.405 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.533434e-01 | 0.452 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.289924e-01 | 0.889 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.914516e-01 | 0.718 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.084647e-01 | 0.681 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.394277e-01 | 0.469 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.089749e-01 | 0.680 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.464224e-01 | 0.460 |
| R-HSA-5632684 | Hedgehog 'on' state | 2.051135e-01 | 0.688 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.251218e-01 | 0.648 |
| R-HSA-69236 | G1 Phase | 1.061941e-01 | 0.974 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.061941e-01 | 0.974 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 9.850408e-02 | 1.007 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 8.146404e-02 | 1.089 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.168373e-01 | 0.664 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.333192e-01 | 0.632 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 2.333192e-01 | 0.632 |
| R-HSA-420029 | Tight junction interactions | 2.807243e-01 | 0.552 |
| R-HSA-380287 | Centrosome maturation | 2.206021e-01 | 0.656 |
| R-HSA-2682334 | EPH-Ephrin signaling | 9.563416e-02 | 1.019 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.106970e-01 | 0.508 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.883368e-01 | 0.540 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.298931e-01 | 0.482 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.652557e-01 | 0.576 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.946550e-02 | 1.531 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 6.518991e-02 | 1.186 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.533434e-01 | 0.452 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.997925e-01 | 0.398 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.196865e-01 | 0.922 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 4.348688e-02 | 1.362 |
| R-HSA-8875878 | MET promotes cell motility | 8.334906e-02 | 1.079 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 8.651104e-02 | 1.063 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.494563e-01 | 0.603 |
| R-HSA-9839394 | TGFBR3 expression | 2.807243e-01 | 0.552 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.252144e-01 | 0.488 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.533434e-01 | 0.452 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.400901e-01 | 0.620 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.933658e-01 | 0.405 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.933658e-01 | 0.405 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.933658e-01 | 0.405 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.997925e-01 | 0.398 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.868707e-01 | 0.412 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.870487e-01 | 0.412 |
| R-HSA-186712 | Regulation of beta-cell development | 3.521942e-02 | 1.453 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.179941e-01 | 0.498 |
| R-HSA-4086400 | PCP/CE pathway | 2.322817e-01 | 0.634 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 8.146404e-02 | 1.089 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.883368e-01 | 0.540 |
| R-HSA-9930044 | Nuclear RNA decay | 3.394277e-01 | 0.469 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.394277e-01 | 0.469 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.803065e-01 | 0.420 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.803065e-01 | 0.420 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 3.933658e-01 | 0.405 |
| R-HSA-73894 | DNA Repair | 5.110527e-02 | 1.292 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 1.740751e-01 | 0.759 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.697314e-02 | 1.013 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.461512e-01 | 0.835 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.376129e-01 | 0.472 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.868707e-01 | 0.412 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 4.348688e-02 | 1.362 |
| R-HSA-170968 | Frs2-mediated activation | 1.652481e-01 | 0.782 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.634870e-02 | 1.178 |
| R-HSA-1640170 | Cell Cycle | 1.544086e-01 | 0.811 |
| R-HSA-8964038 | LDL clearance | 2.573977e-01 | 0.589 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.182690e-01 | 0.497 |
| R-HSA-392517 | Rap1 signalling | 2.251218e-01 | 0.648 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.251218e-01 | 0.648 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.997925e-01 | 0.398 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.868707e-01 | 0.412 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.102421e-01 | 0.958 |
| R-HSA-6806834 | Signaling by MET | 6.815196e-02 | 1.167 |
| R-HSA-2028269 | Signaling by Hippo | 2.084647e-01 | 0.681 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.400901e-01 | 0.620 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.595950e-01 | 0.797 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.714116e-01 | 0.566 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.196865e-01 | 0.922 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.914516e-01 | 0.718 |
| R-HSA-211000 | Gene Silencing by RNA | 1.339876e-01 | 0.873 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.736724e-01 | 0.428 |
| R-HSA-159418 | Recycling of bile acids and salts | 3.394277e-01 | 0.469 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.179941e-01 | 0.498 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.394277e-01 | 0.469 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.085981e-01 | 0.964 |
| R-HSA-69205 | G1/S-Specific Transcription | 7.713658e-02 | 1.113 |
| R-HSA-162582 | Signal Transduction | 1.585504e-01 | 0.800 |
| R-HSA-169893 | Prolonged ERK activation events | 1.914516e-01 | 0.718 |
| R-HSA-422475 | Axon guidance | 2.549795e-01 | 0.593 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.897554e-01 | 0.722 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 1.740751e-01 | 0.759 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.828093e-01 | 0.738 |
| R-HSA-200425 | Carnitine shuttle | 2.652557e-01 | 0.576 |
| R-HSA-9865881 | Complex III assembly | 2.730309e-01 | 0.564 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.807243e-01 | 0.552 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.807243e-01 | 0.552 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.868707e-01 | 0.412 |
| R-HSA-69206 | G1/S Transition | 1.872536e-01 | 0.728 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.485336e-01 | 0.828 |
| R-HSA-9675108 | Nervous system development | 3.114773e-01 | 0.507 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 3.390142e-02 | 1.470 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.225751e-01 | 0.912 |
| R-HSA-4839726 | Chromatin organization | 3.203901e-01 | 0.494 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.573977e-01 | 0.589 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 2.958692e-01 | 0.529 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.033223e-01 | 0.518 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.394277e-01 | 0.469 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.644088e-01 | 0.438 |
| R-HSA-909733 | Interferon alpha/beta signaling | 3.982382e-01 | 0.400 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.958692e-01 | 0.529 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.453062e-01 | 0.462 |
| R-HSA-9733709 | Cardiogenesis | 6.518991e-02 | 1.186 |
| R-HSA-9833110 | RSV-host interactions | 3.601433e-02 | 1.444 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.323587e-01 | 0.478 |
| R-HSA-373755 | Semaphorin interactions | 4.066459e-02 | 1.391 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 2.652557e-01 | 0.576 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.807243e-01 | 0.552 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.870487e-01 | 0.412 |
| R-HSA-186763 | Downstream signal transduction | 3.252144e-01 | 0.488 |
| R-HSA-187687 | Signalling to ERKs | 3.601916e-01 | 0.443 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.669676e-01 | 0.435 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.883368e-01 | 0.540 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.061515e-01 | 0.391 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.533434e-01 | 0.452 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 3.669676e-01 | 0.435 |
| R-HSA-166520 | Signaling by NTRKs | 2.591020e-01 | 0.587 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.382005e-01 | 0.859 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.522032e-01 | 0.818 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.061515e-01 | 0.391 |
| R-HSA-8853659 | RET signaling | 3.669676e-01 | 0.435 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.333559e-02 | 1.632 |
| R-HSA-69275 | G2/M Transition | 3.713943e-01 | 0.430 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.601916e-01 | 0.443 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.771348e-01 | 0.424 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.736724e-01 | 0.428 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.394277e-01 | 0.469 |
| R-HSA-9614085 | FOXO-mediated transcription | 3.260240e-01 | 0.487 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 8.585618e-02 | 1.066 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.282655e-02 | 1.082 |
| R-HSA-5693538 | Homology Directed Repair | 4.093332e-01 | 0.388 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.124436e-01 | 0.385 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.161299e-01 | 0.381 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 4.186693e-01 | 0.378 |
| R-HSA-73886 | Chromosome Maintenance | 4.203286e-01 | 0.376 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.248295e-01 | 0.372 |
| R-HSA-72172 | mRNA Splicing | 4.254071e-01 | 0.371 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.309248e-01 | 0.366 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.309248e-01 | 0.366 |
| R-HSA-774815 | Nucleosome assembly | 4.309248e-01 | 0.366 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.309248e-01 | 0.366 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.309248e-01 | 0.366 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.309248e-01 | 0.366 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.312197e-01 | 0.365 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.326938e-01 | 0.364 |
| R-HSA-1266738 | Developmental Biology | 4.327944e-01 | 0.364 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.369558e-01 | 0.360 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.369558e-01 | 0.360 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.369558e-01 | 0.360 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.369558e-01 | 0.360 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.369558e-01 | 0.360 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.369558e-01 | 0.360 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.369558e-01 | 0.360 |
| R-HSA-9675135 | Diseases of DNA repair | 4.369558e-01 | 0.360 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.369558e-01 | 0.360 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.384205e-01 | 0.358 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.384205e-01 | 0.358 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.384205e-01 | 0.358 |
| R-HSA-437239 | Recycling pathway of L1 | 4.429233e-01 | 0.354 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.429233e-01 | 0.354 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.476948e-01 | 0.349 |
| R-HSA-5620924 | Intraflagellar transport | 4.488279e-01 | 0.348 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.491285e-01 | 0.348 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.546703e-01 | 0.342 |
| R-HSA-68882 | Mitotic Anaphase | 4.587114e-01 | 0.338 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.604511e-01 | 0.337 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.614513e-01 | 0.336 |
| R-HSA-388396 | GPCR downstream signalling | 4.704715e-01 | 0.327 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.718307e-01 | 0.326 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.718307e-01 | 0.326 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.774306e-01 | 0.321 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.774306e-01 | 0.321 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.774306e-01 | 0.321 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.774306e-01 | 0.321 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.839742e-01 | 0.315 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.884541e-01 | 0.311 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.884541e-01 | 0.311 |
| R-HSA-162906 | HIV Infection | 4.885129e-01 | 0.311 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.907801e-01 | 0.309 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.938788e-01 | 0.306 |
| R-HSA-177929 | Signaling by EGFR | 4.938788e-01 | 0.306 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.992463e-01 | 0.302 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.045572e-01 | 0.297 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.070633e-01 | 0.295 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.075476e-01 | 0.295 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.098121e-01 | 0.293 |
| R-HSA-191859 | snRNP Assembly | 5.098121e-01 | 0.293 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.119947e-01 | 0.291 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.150117e-01 | 0.288 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.150117e-01 | 0.288 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.150117e-01 | 0.288 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.150117e-01 | 0.288 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.150117e-01 | 0.288 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 5.150117e-01 | 0.288 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.150117e-01 | 0.288 |
| R-HSA-351202 | Metabolism of polyamines | 5.150117e-01 | 0.288 |
| R-HSA-211976 | Endogenous sterols | 5.201563e-01 | 0.284 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.201563e-01 | 0.284 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.239545e-01 | 0.281 |
| R-HSA-1268020 | Mitochondrial protein import | 5.252468e-01 | 0.280 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.252468e-01 | 0.280 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.252468e-01 | 0.280 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.252468e-01 | 0.280 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.252468e-01 | 0.280 |
| R-HSA-9707616 | Heme signaling | 5.252468e-01 | 0.280 |
| R-HSA-186797 | Signaling by PDGF | 5.252468e-01 | 0.280 |
| R-HSA-69242 | S Phase | 5.271919e-01 | 0.278 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.302835e-01 | 0.275 |
| R-HSA-9758941 | Gastrulation | 5.304145e-01 | 0.275 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.401981e-01 | 0.267 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.482704e-01 | 0.261 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.494368e-01 | 0.260 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 5.499047e-01 | 0.260 |
| R-HSA-167172 | Transcription of the HIV genome | 5.546813e-01 | 0.256 |
| R-HSA-162587 | HIV Life Cycle | 5.556572e-01 | 0.255 |
| R-HSA-9610379 | HCMV Late Events | 5.556572e-01 | 0.255 |
| R-HSA-877300 | Interferon gamma signaling | 5.618170e-01 | 0.250 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.640839e-01 | 0.249 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.640839e-01 | 0.249 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.687109e-01 | 0.245 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.687109e-01 | 0.245 |
| R-HSA-199991 | Membrane Trafficking | 5.691440e-01 | 0.245 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.732890e-01 | 0.242 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.778189e-01 | 0.238 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.778189e-01 | 0.238 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.823009e-01 | 0.235 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.823009e-01 | 0.235 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.823009e-01 | 0.235 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 5.867357e-01 | 0.232 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.867357e-01 | 0.232 |
| R-HSA-372790 | Signaling by GPCR | 5.908711e-01 | 0.229 |
| R-HSA-5689603 | UCH proteinases | 5.911236e-01 | 0.228 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.911236e-01 | 0.228 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.954652e-01 | 0.225 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.997610e-01 | 0.222 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.997610e-01 | 0.222 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.082169e-01 | 0.216 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.123781e-01 | 0.213 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.164953e-01 | 0.210 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.205690e-01 | 0.207 |
| R-HSA-168255 | Influenza Infection | 6.228019e-01 | 0.206 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.245997e-01 | 0.204 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.285878e-01 | 0.202 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.325338e-01 | 0.199 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.325338e-01 | 0.199 |
| R-HSA-70268 | Pyruvate metabolism | 6.403012e-01 | 0.194 |
| R-HSA-73884 | Base Excision Repair | 6.516473e-01 | 0.186 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.553497e-01 | 0.184 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.553497e-01 | 0.184 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.626375e-01 | 0.179 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.732829e-01 | 0.172 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.767567e-01 | 0.170 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.770660e-01 | 0.169 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.801937e-01 | 0.167 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.801937e-01 | 0.167 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.818903e-01 | 0.166 |
| R-HSA-157579 | Telomere Maintenance | 6.835944e-01 | 0.165 |
| R-HSA-190236 | Signaling by FGFR | 6.869591e-01 | 0.163 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.869591e-01 | 0.163 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.869591e-01 | 0.163 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.869591e-01 | 0.163 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.902883e-01 | 0.161 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.935822e-01 | 0.159 |
| R-HSA-70171 | Glycolysis | 6.935822e-01 | 0.159 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.000660e-01 | 0.155 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.000660e-01 | 0.155 |
| R-HSA-1483255 | PI Metabolism | 7.000660e-01 | 0.155 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.064134e-01 | 0.151 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.077534e-01 | 0.150 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.077534e-01 | 0.150 |
| R-HSA-8957322 | Metabolism of steroids | 7.096079e-01 | 0.149 |
| R-HSA-69239 | Synthesis of DNA | 7.187102e-01 | 0.143 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.217036e-01 | 0.142 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.246653e-01 | 0.140 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.246653e-01 | 0.140 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.246653e-01 | 0.140 |
| R-HSA-8951664 | Neddylation | 7.269640e-01 | 0.138 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.275956e-01 | 0.138 |
| R-HSA-6803157 | Antimicrobial peptides | 7.304949e-01 | 0.136 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.333636e-01 | 0.135 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.333636e-01 | 0.135 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.333636e-01 | 0.135 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.362019e-01 | 0.133 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.362019e-01 | 0.133 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.445378e-01 | 0.128 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.472578e-01 | 0.127 |
| R-HSA-373760 | L1CAM interactions | 7.499491e-01 | 0.125 |
| R-HSA-70326 | Glucose metabolism | 7.526118e-01 | 0.123 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.526118e-01 | 0.123 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.578530e-01 | 0.120 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.578530e-01 | 0.120 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.578530e-01 | 0.120 |
| R-HSA-68875 | Mitotic Prophase | 7.604321e-01 | 0.119 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.629838e-01 | 0.117 |
| R-HSA-3371556 | Cellular response to heat stress | 7.629838e-01 | 0.117 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.655085e-01 | 0.116 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.655085e-01 | 0.116 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.680065e-01 | 0.115 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.680065e-01 | 0.115 |
| R-HSA-194138 | Signaling by VEGF | 7.753429e-01 | 0.111 |
| R-HSA-2262752 | Cellular responses to stress | 7.798431e-01 | 0.108 |
| R-HSA-114608 | Platelet degranulation | 7.801051e-01 | 0.108 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.818858e-01 | 0.107 |
| R-HSA-9609646 | HCMV Infection | 7.826813e-01 | 0.106 |
| R-HSA-212436 | Generic Transcription Pathway | 7.923410e-01 | 0.101 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.937981e-01 | 0.100 |
| R-HSA-9909396 | Circadian clock | 7.937981e-01 | 0.100 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.959964e-01 | 0.099 |
| R-HSA-8953897 | Cellular responses to stimuli | 7.993989e-01 | 0.097 |
| R-HSA-68886 | M Phase | 8.037124e-01 | 0.095 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.042676e-01 | 0.095 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.045589e-01 | 0.094 |
| R-HSA-163685 | Integration of energy metabolism | 8.045589e-01 | 0.094 |
| R-HSA-913531 | Interferon Signaling | 8.050606e-01 | 0.094 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.087052e-01 | 0.092 |
| R-HSA-6807070 | PTEN Regulation | 8.107454e-01 | 0.091 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.120528e-01 | 0.090 |
| R-HSA-9664407 | Parasite infection | 8.127640e-01 | 0.090 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.127640e-01 | 0.090 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.127640e-01 | 0.090 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.147612e-01 | 0.089 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.186923e-01 | 0.087 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.201835e-01 | 0.086 |
| R-HSA-446728 | Cell junction organization | 8.268034e-01 | 0.083 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.299948e-01 | 0.081 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.336043e-01 | 0.079 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.353805e-01 | 0.078 |
| R-HSA-9609507 | Protein localization | 8.388763e-01 | 0.076 |
| R-HSA-69306 | DNA Replication | 8.388763e-01 | 0.076 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.405965e-01 | 0.075 |
| R-HSA-9711097 | Cellular response to starvation | 8.472965e-01 | 0.072 |
| R-HSA-195721 | Signaling by WNT | 8.532337e-01 | 0.069 |
| R-HSA-109581 | Apoptosis | 8.537165e-01 | 0.069 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.568251e-01 | 0.067 |
| R-HSA-74160 | Gene expression (Transcription) | 8.605603e-01 | 0.065 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.613653e-01 | 0.065 |
| R-HSA-5619102 | SLC transporter disorders | 8.613653e-01 | 0.065 |
| R-HSA-72306 | tRNA processing | 8.671970e-01 | 0.062 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.727848e-01 | 0.059 |
| R-HSA-1500931 | Cell-Cell communication | 8.738383e-01 | 0.059 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.780423e-01 | 0.056 |
| R-HSA-611105 | Respiratory electron transport | 8.781387e-01 | 0.056 |
| R-HSA-2559583 | Cellular Senescence | 8.807311e-01 | 0.055 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.919273e-01 | 0.050 |
| R-HSA-5617833 | Cilium Assembly | 8.928932e-01 | 0.049 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.940394e-01 | 0.049 |
| R-HSA-112316 | Neuronal System | 8.943245e-01 | 0.049 |
| R-HSA-8953854 | Metabolism of RNA | 8.960843e-01 | 0.048 |
| R-HSA-68877 | Mitotic Prometaphase | 8.962953e-01 | 0.048 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.980768e-01 | 0.047 |
| R-HSA-9609690 | HCMV Early Events | 8.995900e-01 | 0.046 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.068785e-01 | 0.042 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.068785e-01 | 0.042 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.068785e-01 | 0.042 |
| R-HSA-5357801 | Programmed Cell Death | 9.098388e-01 | 0.041 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.157643e-01 | 0.038 |
| R-HSA-397014 | Muscle contraction | 9.163873e-01 | 0.038 |
| R-HSA-9824446 | Viral Infection Pathways | 9.260355e-01 | 0.033 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.261493e-01 | 0.033 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.280992e-01 | 0.032 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.296334e-01 | 0.032 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.311351e-01 | 0.031 |
| R-HSA-8939211 | ESR-mediated signaling | 9.361444e-01 | 0.029 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.361444e-01 | 0.029 |
| R-HSA-157118 | Signaling by NOTCH | 9.381788e-01 | 0.028 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.426785e-01 | 0.026 |
| R-HSA-421270 | Cell-cell junction organization | 9.451019e-01 | 0.025 |
| R-HSA-5688426 | Deubiquitination | 9.474235e-01 | 0.023 |
| R-HSA-69620 | Cell Cycle Checkpoints | 9.491004e-01 | 0.023 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.505068e-01 | 0.022 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.571855e-01 | 0.019 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.589987e-01 | 0.018 |
| R-HSA-9658195 | Leishmania infection | 9.603083e-01 | 0.018 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.603083e-01 | 0.018 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.607355e-01 | 0.017 |
| R-HSA-6798695 | Neutrophil degranulation | 9.639640e-01 | 0.016 |
| R-HSA-1483257 | Phospholipid metabolism | 9.658905e-01 | 0.015 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.658905e-01 | 0.015 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.795136e-01 | 0.009 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.810140e-01 | 0.008 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.838713e-01 | 0.007 |
| R-HSA-9679506 | SARS-CoV Infections | 9.855185e-01 | 0.006 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.870268e-01 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.879794e-01 | 0.005 |
| R-HSA-5663205 | Infectious disease | 9.895696e-01 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 9.900131e-01 | 0.004 |
| R-HSA-8978868 | Fatty acid metabolism | 9.900131e-01 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.920634e-01 | 0.003 |
| R-HSA-72766 | Translation | 9.921454e-01 | 0.003 |
| R-HSA-109582 | Hemostasis | 9.921916e-01 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.940889e-01 | 0.003 |
| R-HSA-597592 | Post-translational protein modification | 9.944163e-01 | 0.002 |
| R-HSA-168249 | Innate Immune System | 9.966842e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.971698e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.971958e-01 | 0.001 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.975916e-01 | 0.001 |
| R-HSA-449147 | Signaling by Interleukins | 9.990894e-01 | 0.000 |
| R-HSA-1280218 | Adaptive Immune System | 9.993006e-01 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 9.999503e-01 | 0.000 |
| R-HSA-1643685 | Disease | 9.999572e-01 | 0.000 |
| R-HSA-168256 | Immune System | 9.999762e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.999831e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999998e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
P38G |
0.849 | 0.823 | 1 | 0.869 |
CDK7 |
0.847 | 0.777 | 1 | 0.786 |
JNK2 |
0.845 | 0.832 | 1 | 0.833 |
CDK17 |
0.845 | 0.789 | 1 | 0.860 |
CDK19 |
0.844 | 0.756 | 1 | 0.819 |
CDK18 |
0.843 | 0.767 | 1 | 0.829 |
KIS |
0.843 | 0.692 | 1 | 0.767 |
CDK8 |
0.841 | 0.763 | 1 | 0.784 |
HIPK2 |
0.839 | 0.710 | 1 | 0.811 |
CDK12 |
0.838 | 0.779 | 1 | 0.830 |
CDK13 |
0.837 | 0.771 | 1 | 0.807 |
CDK3 |
0.837 | 0.688 | 1 | 0.851 |
ERK1 |
0.835 | 0.774 | 1 | 0.813 |
CDK5 |
0.834 | 0.732 | 1 | 0.756 |
CDK16 |
0.834 | 0.750 | 1 | 0.845 |
P38B |
0.834 | 0.783 | 1 | 0.797 |
P38D |
0.833 | 0.792 | 1 | 0.866 |
JNK3 |
0.833 | 0.812 | 1 | 0.802 |
CDK9 |
0.833 | 0.767 | 1 | 0.800 |
DYRK2 |
0.832 | 0.711 | 1 | 0.726 |
CDK10 |
0.831 | 0.720 | 1 | 0.809 |
CDK1 |
0.830 | 0.736 | 1 | 0.807 |
CDK14 |
0.829 | 0.760 | 1 | 0.793 |
CDK4 |
0.828 | 0.772 | 1 | 0.837 |
DYRK4 |
0.827 | 0.717 | 1 | 0.822 |
DYRK1B |
0.827 | 0.701 | 1 | 0.782 |
P38A |
0.826 | 0.765 | 1 | 0.728 |
ERK2 |
0.825 | 0.783 | 1 | 0.762 |
NLK |
0.825 | 0.762 | 1 | 0.523 |
HIPK1 |
0.823 | 0.660 | 1 | 0.707 |
CDK6 |
0.822 | 0.737 | 1 | 0.813 |
HIPK3 |
0.818 | 0.652 | 1 | 0.688 |
DYRK1A |
0.817 | 0.594 | 1 | 0.695 |
HIPK4 |
0.814 | 0.440 | 1 | 0.512 |
CDK2 |
0.813 | 0.595 | 1 | 0.685 |
DYRK3 |
0.812 | 0.555 | 1 | 0.673 |
CLK3 |
0.812 | 0.420 | 1 | 0.482 |
JNK1 |
0.811 | 0.726 | 1 | 0.828 |
SRPK1 |
0.811 | 0.336 | -3 | 0.800 |
ERK5 |
0.809 | 0.415 | 1 | 0.427 |
CLK1 |
0.805 | 0.416 | -3 | 0.784 |
SRPK2 |
0.804 | 0.282 | -3 | 0.732 |
CLK4 |
0.802 | 0.389 | -3 | 0.810 |
PRP4 |
0.797 | 0.518 | -3 | 0.889 |
CDKL5 |
0.795 | 0.185 | -3 | 0.837 |
CLK2 |
0.795 | 0.386 | -3 | 0.795 |
ICK |
0.795 | 0.347 | -3 | 0.869 |
MTOR |
0.794 | 0.173 | 1 | 0.313 |
COT |
0.792 | -0.071 | 2 | 0.852 |
SRPK3 |
0.791 | 0.249 | -3 | 0.772 |
CDKL1 |
0.791 | 0.166 | -3 | 0.842 |
MOK |
0.789 | 0.452 | 1 | 0.589 |
MAK |
0.789 | 0.463 | -2 | 0.775 |
TBK1 |
0.786 | -0.105 | 1 | 0.126 |
CDC7 |
0.784 | -0.086 | 1 | 0.134 |
IKKE |
0.784 | -0.107 | 1 | 0.127 |
MST4 |
0.783 | -0.012 | 2 | 0.834 |
ERK7 |
0.783 | 0.275 | 2 | 0.534 |
GCN2 |
0.783 | -0.136 | 2 | 0.758 |
NUAK2 |
0.783 | 0.051 | -3 | 0.865 |
RAF1 |
0.781 | -0.139 | 1 | 0.136 |
PIM3 |
0.781 | -0.014 | -3 | 0.867 |
PRPK |
0.781 | -0.077 | -1 | 0.732 |
NDR2 |
0.781 | -0.018 | -3 | 0.858 |
TGFBR2 |
0.781 | -0.026 | -2 | 0.841 |
NDR1 |
0.780 | -0.008 | -3 | 0.861 |
RSK3 |
0.779 | 0.035 | -3 | 0.815 |
MOS |
0.779 | -0.045 | 1 | 0.178 |
PKN3 |
0.779 | -0.014 | -3 | 0.861 |
IKKB |
0.778 | -0.121 | -2 | 0.821 |
CAMK1B |
0.778 | 0.002 | -3 | 0.885 |
PRKD2 |
0.778 | 0.030 | -3 | 0.807 |
DSTYK |
0.777 | -0.115 | 2 | 0.856 |
WNK1 |
0.777 | -0.048 | -2 | 0.911 |
PRKD1 |
0.776 | -0.007 | -3 | 0.859 |
CAMLCK |
0.776 | 0.055 | -2 | 0.912 |
AMPKA1 |
0.776 | -0.016 | -3 | 0.876 |
PDHK4 |
0.776 | -0.128 | 1 | 0.197 |
ATR |
0.776 | -0.038 | 1 | 0.179 |
P90RSK |
0.776 | 0.035 | -3 | 0.826 |
RSK2 |
0.776 | 0.032 | -3 | 0.814 |
MAPKAPK3 |
0.776 | 0.005 | -3 | 0.819 |
ULK2 |
0.776 | -0.160 | 2 | 0.741 |
BMPR2 |
0.775 | -0.100 | -2 | 0.925 |
NEK6 |
0.775 | -0.078 | -2 | 0.890 |
PKCD |
0.775 | -0.006 | 2 | 0.755 |
PKN2 |
0.774 | -0.029 | -3 | 0.863 |
NIK |
0.774 | -0.019 | -3 | 0.898 |
P70S6KB |
0.774 | 0.039 | -3 | 0.836 |
AMPKA2 |
0.774 | 0.004 | -3 | 0.848 |
PDHK1 |
0.774 | -0.143 | 1 | 0.183 |
MARK4 |
0.773 | -0.034 | 4 | 0.864 |
RIPK3 |
0.773 | -0.088 | 3 | 0.728 |
NEK7 |
0.773 | -0.132 | -3 | 0.841 |
PIM1 |
0.773 | 0.040 | -3 | 0.817 |
WNK3 |
0.772 | -0.113 | 1 | 0.137 |
PHKG1 |
0.771 | -0.025 | -3 | 0.861 |
AURC |
0.771 | 0.044 | -2 | 0.729 |
PAK6 |
0.771 | 0.044 | -2 | 0.788 |
NEK9 |
0.771 | -0.091 | 2 | 0.807 |
PKACG |
0.771 | 0.004 | -2 | 0.813 |
SMG1 |
0.770 | 0.076 | 1 | 0.163 |
MELK |
0.770 | -0.007 | -3 | 0.841 |
PRKD3 |
0.770 | 0.033 | -3 | 0.785 |
DAPK2 |
0.770 | 0.014 | -3 | 0.895 |
SKMLCK |
0.770 | -0.030 | -2 | 0.909 |
MLK1 |
0.770 | -0.118 | 2 | 0.784 |
BCKDK |
0.769 | -0.134 | -1 | 0.689 |
IRE1 |
0.769 | -0.079 | 1 | 0.131 |
TSSK1 |
0.769 | -0.023 | -3 | 0.893 |
PAK3 |
0.769 | -0.008 | -2 | 0.852 |
ATM |
0.768 | -0.047 | 1 | 0.146 |
MLK2 |
0.768 | -0.080 | 2 | 0.791 |
MNK2 |
0.768 | -0.002 | -2 | 0.856 |
CHAK2 |
0.768 | -0.060 | -1 | 0.695 |
LATS2 |
0.767 | -0.039 | -5 | 0.787 |
IRE2 |
0.766 | -0.065 | 2 | 0.713 |
NUAK1 |
0.766 | -0.012 | -3 | 0.821 |
NIM1 |
0.766 | -0.057 | 3 | 0.759 |
HUNK |
0.766 | -0.137 | 2 | 0.774 |
MAPKAPK2 |
0.765 | -0.006 | -3 | 0.774 |
PKG2 |
0.765 | 0.042 | -2 | 0.742 |
CAMK2G |
0.765 | -0.111 | 2 | 0.761 |
QIK |
0.765 | -0.047 | -3 | 0.863 |
DNAPK |
0.765 | -0.032 | 1 | 0.177 |
QSK |
0.764 | -0.009 | 4 | 0.856 |
PKCB |
0.764 | -0.022 | 2 | 0.714 |
SIK |
0.764 | -0.007 | -3 | 0.804 |
AURB |
0.764 | 0.035 | -2 | 0.729 |
TSSK2 |
0.764 | -0.057 | -5 | 0.850 |
AKT2 |
0.763 | 0.063 | -3 | 0.738 |
PAK1 |
0.763 | -0.013 | -2 | 0.848 |
SGK3 |
0.763 | 0.030 | -3 | 0.804 |
MASTL |
0.763 | -0.135 | -2 | 0.876 |
PINK1 |
0.762 | 0.163 | 1 | 0.341 |
CAMK2D |
0.762 | -0.084 | -3 | 0.875 |
ULK1 |
0.762 | -0.172 | -3 | 0.818 |
PKCA |
0.762 | -0.020 | 2 | 0.698 |
PKCG |
0.762 | -0.035 | 2 | 0.702 |
CAMK4 |
0.762 | -0.064 | -3 | 0.845 |
RIPK1 |
0.762 | -0.145 | 1 | 0.124 |
PIM2 |
0.762 | 0.060 | -3 | 0.790 |
MSK2 |
0.761 | -0.006 | -3 | 0.794 |
PKCZ |
0.761 | -0.044 | 2 | 0.747 |
BRSK2 |
0.761 | -0.041 | -3 | 0.849 |
PKR |
0.761 | -0.052 | 1 | 0.154 |
MLK3 |
0.760 | -0.068 | 2 | 0.711 |
MYLK4 |
0.760 | 0.031 | -2 | 0.842 |
IKKA |
0.760 | -0.116 | -2 | 0.805 |
ALK4 |
0.760 | -0.029 | -2 | 0.868 |
NEK2 |
0.760 | -0.097 | 2 | 0.779 |
BRSK1 |
0.759 | -0.023 | -3 | 0.831 |
GRK5 |
0.759 | -0.164 | -3 | 0.849 |
PAK2 |
0.759 | -0.015 | -2 | 0.842 |
PAK5 |
0.759 | 0.028 | -2 | 0.732 |
BMPR1B |
0.759 | -0.040 | 1 | 0.102 |
PKACB |
0.759 | 0.038 | -2 | 0.745 |
PKCH |
0.759 | -0.040 | 2 | 0.688 |
ANKRD3 |
0.758 | -0.160 | 1 | 0.153 |
RSK4 |
0.758 | 0.022 | -3 | 0.781 |
TGFBR1 |
0.758 | -0.037 | -2 | 0.840 |
YSK4 |
0.758 | -0.116 | 1 | 0.125 |
VRK2 |
0.757 | 0.072 | 1 | 0.234 |
AKT1 |
0.757 | 0.050 | -3 | 0.755 |
MNK1 |
0.757 | -0.017 | -2 | 0.868 |
TTBK2 |
0.757 | -0.150 | 2 | 0.652 |
PKCT |
0.756 | -0.024 | 2 | 0.698 |
MAPKAPK5 |
0.755 | -0.033 | -3 | 0.784 |
MPSK1 |
0.755 | 0.020 | 1 | 0.195 |
DLK |
0.755 | -0.202 | 1 | 0.146 |
MARK2 |
0.755 | -0.022 | 4 | 0.785 |
MARK3 |
0.755 | -0.022 | 4 | 0.820 |
LATS1 |
0.754 | -0.034 | -3 | 0.873 |
PAK4 |
0.754 | 0.030 | -2 | 0.735 |
MSK1 |
0.754 | 0.010 | -3 | 0.800 |
PHKG2 |
0.754 | -0.045 | -3 | 0.827 |
P70S6K |
0.753 | 0.028 | -3 | 0.761 |
MEK1 |
0.753 | -0.091 | 2 | 0.793 |
GRK6 |
0.753 | -0.140 | 1 | 0.127 |
AURA |
0.753 | 0.019 | -2 | 0.703 |
SNRK |
0.753 | -0.093 | 2 | 0.605 |
IRAK4 |
0.753 | -0.085 | 1 | 0.117 |
CHK1 |
0.753 | -0.045 | -3 | 0.851 |
GRK1 |
0.753 | -0.085 | -2 | 0.867 |
HRI |
0.752 | -0.107 | -2 | 0.888 |
CHAK1 |
0.752 | -0.125 | 2 | 0.730 |
WNK4 |
0.751 | -0.085 | -2 | 0.895 |
PKCI |
0.751 | -0.009 | 2 | 0.714 |
PLK1 |
0.751 | -0.122 | -2 | 0.866 |
MST3 |
0.751 | -0.032 | 2 | 0.812 |
PERK |
0.751 | -0.104 | -2 | 0.882 |
PKN1 |
0.750 | 0.007 | -3 | 0.775 |
ACVR2A |
0.750 | -0.078 | -2 | 0.828 |
MEKK1 |
0.750 | -0.122 | 1 | 0.154 |
CAMK2B |
0.750 | -0.072 | 2 | 0.740 |
CAMK1G |
0.750 | -0.030 | -3 | 0.803 |
MLK4 |
0.749 | -0.122 | 2 | 0.689 |
ALK2 |
0.749 | -0.053 | -2 | 0.851 |
GRK4 |
0.749 | -0.165 | -2 | 0.872 |
DRAK1 |
0.749 | -0.110 | 1 | 0.098 |
DCAMKL1 |
0.749 | -0.027 | -3 | 0.821 |
MARK1 |
0.749 | -0.051 | 4 | 0.838 |
ACVR2B |
0.748 | -0.082 | -2 | 0.841 |
PLK4 |
0.748 | -0.115 | 2 | 0.557 |
MEK5 |
0.748 | -0.107 | 2 | 0.781 |
PRKX |
0.748 | 0.036 | -3 | 0.720 |
SSTK |
0.747 | -0.031 | 4 | 0.848 |
FAM20C |
0.747 | -0.042 | 2 | 0.574 |
NEK5 |
0.747 | -0.097 | 1 | 0.130 |
CAMK2A |
0.747 | -0.053 | 2 | 0.756 |
PKACA |
0.746 | 0.036 | -2 | 0.690 |
SMMLCK |
0.746 | 0.009 | -3 | 0.850 |
TAO3 |
0.746 | -0.054 | 1 | 0.171 |
ZAK |
0.745 | -0.150 | 1 | 0.137 |
GRK7 |
0.745 | -0.054 | 1 | 0.152 |
MEKK2 |
0.745 | -0.100 | 2 | 0.769 |
AKT3 |
0.745 | 0.053 | -3 | 0.680 |
TAO2 |
0.745 | -0.018 | 2 | 0.813 |
BRAF |
0.744 | -0.122 | -4 | 0.839 |
TLK2 |
0.744 | -0.140 | 1 | 0.126 |
MRCKB |
0.744 | 0.060 | -3 | 0.780 |
PKCE |
0.744 | 0.009 | 2 | 0.690 |
BMPR1A |
0.743 | -0.054 | 1 | 0.097 |
LKB1 |
0.742 | -0.022 | -3 | 0.872 |
PLK3 |
0.742 | -0.126 | 2 | 0.706 |
LOK |
0.741 | -0.019 | -2 | 0.851 |
MEKK3 |
0.741 | -0.158 | 1 | 0.145 |
SGK1 |
0.741 | 0.067 | -3 | 0.666 |
DCAMKL2 |
0.741 | -0.045 | -3 | 0.838 |
SBK |
0.740 | 0.131 | -3 | 0.625 |
IRAK1 |
0.739 | -0.156 | -1 | 0.691 |
NEK4 |
0.739 | -0.099 | 1 | 0.128 |
PDK1 |
0.739 | -0.044 | 1 | 0.175 |
TLK1 |
0.739 | -0.130 | -2 | 0.859 |
NEK8 |
0.739 | -0.115 | 2 | 0.777 |
TTBK1 |
0.739 | -0.114 | 2 | 0.567 |
GSK3A |
0.738 | 0.130 | 4 | 0.338 |
ROCK2 |
0.738 | 0.037 | -3 | 0.825 |
CHK2 |
0.738 | 0.022 | -3 | 0.688 |
MRCKA |
0.738 | 0.038 | -3 | 0.794 |
HGK |
0.737 | -0.056 | 3 | 0.820 |
CAMK1D |
0.737 | -0.010 | -3 | 0.731 |
PKG1 |
0.737 | 0.031 | -2 | 0.653 |
HPK1 |
0.737 | -0.039 | 1 | 0.155 |
MEKK6 |
0.737 | -0.081 | 1 | 0.146 |
NEK11 |
0.736 | -0.132 | 1 | 0.167 |
TNIK |
0.736 | -0.045 | 3 | 0.820 |
GRK2 |
0.735 | -0.103 | -2 | 0.754 |
NEK3 |
0.735 | -0.049 | 1 | 0.154 |
GCK |
0.735 | -0.077 | 1 | 0.151 |
PBK |
0.735 | -0.022 | 1 | 0.165 |
NEK1 |
0.734 | -0.086 | 1 | 0.119 |
GAK |
0.734 | -0.052 | 1 | 0.178 |
MINK |
0.734 | -0.096 | 1 | 0.130 |
KHS1 |
0.733 | -0.041 | 1 | 0.150 |
DAPK3 |
0.733 | -0.004 | -3 | 0.837 |
CAMKK1 |
0.733 | -0.147 | -2 | 0.833 |
KHS2 |
0.732 | -0.016 | 1 | 0.160 |
MAP3K15 |
0.732 | -0.110 | 1 | 0.149 |
MST2 |
0.732 | -0.112 | 1 | 0.136 |
CAMK1A |
0.732 | 0.011 | -3 | 0.697 |
YSK1 |
0.732 | -0.074 | 2 | 0.783 |
LRRK2 |
0.732 | -0.020 | 2 | 0.800 |
CAMKK2 |
0.731 | -0.117 | -2 | 0.829 |
BUB1 |
0.731 | 0.003 | -5 | 0.778 |
RIPK2 |
0.731 | -0.132 | 1 | 0.126 |
VRK1 |
0.731 | -0.068 | 2 | 0.811 |
ROCK1 |
0.729 | 0.038 | -3 | 0.797 |
TAK1 |
0.729 | -0.106 | 1 | 0.123 |
SLK |
0.728 | -0.067 | -2 | 0.802 |
PASK |
0.728 | -0.089 | -3 | 0.873 |
CK1E |
0.727 | -0.062 | -3 | 0.519 |
HASPIN |
0.727 | -0.007 | -1 | 0.563 |
DMPK1 |
0.727 | 0.053 | -3 | 0.788 |
CRIK |
0.727 | 0.059 | -3 | 0.745 |
EEF2K |
0.726 | -0.085 | 3 | 0.793 |
BIKE |
0.726 | -0.005 | 1 | 0.170 |
DAPK1 |
0.726 | -0.008 | -3 | 0.823 |
GSK3B |
0.726 | -0.007 | 4 | 0.332 |
MST1 |
0.725 | -0.124 | 1 | 0.130 |
CK2A2 |
0.725 | -0.078 | 1 | 0.085 |
MEK2 |
0.724 | -0.114 | 2 | 0.764 |
CK1G1 |
0.723 | -0.085 | -3 | 0.510 |
TAO1 |
0.723 | -0.043 | 1 | 0.149 |
AAK1 |
0.722 | 0.019 | 1 | 0.178 |
CK1D |
0.721 | -0.037 | -3 | 0.465 |
MYO3B |
0.719 | -0.044 | 2 | 0.790 |
STK33 |
0.718 | -0.131 | 2 | 0.547 |
GRK3 |
0.718 | -0.107 | -2 | 0.708 |
CK1A2 |
0.715 | -0.061 | -3 | 0.466 |
LIMK2_TYR |
0.715 | 0.138 | -3 | 0.904 |
OSR1 |
0.715 | -0.076 | 2 | 0.768 |
CK2A1 |
0.714 | -0.086 | 1 | 0.078 |
MYO3A |
0.713 | -0.072 | 1 | 0.151 |
PDHK3_TYR |
0.712 | 0.068 | 4 | 0.860 |
TTK |
0.712 | -0.076 | -2 | 0.867 |
ASK1 |
0.710 | -0.123 | 1 | 0.148 |
TESK1_TYR |
0.709 | 0.015 | 3 | 0.830 |
PKMYT1_TYR |
0.709 | 0.074 | 3 | 0.813 |
RET |
0.705 | -0.074 | 1 | 0.162 |
PLK2 |
0.705 | -0.114 | -3 | 0.788 |
MAP2K7_TYR |
0.705 | -0.050 | 2 | 0.806 |
MAP2K4_TYR |
0.704 | -0.016 | -1 | 0.753 |
NEK10_TYR |
0.703 | -0.044 | 1 | 0.140 |
LIMK1_TYR |
0.703 | 0.007 | 2 | 0.807 |
MST1R |
0.702 | -0.052 | 3 | 0.781 |
PDHK4_TYR |
0.702 | -0.017 | 2 | 0.830 |
PINK1_TYR |
0.701 | -0.119 | 1 | 0.183 |
JAK2 |
0.700 | -0.091 | 1 | 0.175 |
STLK3 |
0.700 | -0.127 | 1 | 0.126 |
TXK |
0.700 | 0.001 | 1 | 0.106 |
CSF1R |
0.700 | -0.059 | 3 | 0.778 |
TYRO3 |
0.700 | -0.045 | 3 | 0.782 |
ROS1 |
0.700 | -0.072 | 3 | 0.772 |
TYK2 |
0.699 | -0.157 | 1 | 0.152 |
MAP2K6_TYR |
0.698 | -0.053 | -1 | 0.739 |
BMPR2_TYR |
0.698 | -0.047 | -1 | 0.716 |
TNNI3K_TYR |
0.697 | -0.040 | 1 | 0.185 |
JAK1 |
0.697 | -0.065 | 1 | 0.149 |
YES1 |
0.696 | -0.032 | -1 | 0.777 |
ALPHAK3 |
0.695 | -0.126 | -1 | 0.644 |
TEK |
0.695 | 0.055 | 3 | 0.710 |
ABL2 |
0.695 | -0.073 | -1 | 0.733 |
EPHA6 |
0.695 | -0.085 | -1 | 0.742 |
PDHK1_TYR |
0.694 | -0.108 | -1 | 0.751 |
EPHB4 |
0.694 | -0.077 | -1 | 0.767 |
ITK |
0.694 | -0.050 | -1 | 0.762 |
JAK3 |
0.693 | -0.124 | 1 | 0.149 |
TNK1 |
0.692 | -0.055 | 3 | 0.769 |
LCK |
0.692 | -0.052 | -1 | 0.754 |
FGFR1 |
0.692 | -0.026 | 3 | 0.733 |
DDR1 |
0.691 | -0.103 | 4 | 0.787 |
TNK2 |
0.691 | -0.051 | 3 | 0.717 |
ABL1 |
0.691 | -0.079 | -1 | 0.735 |
BLK |
0.690 | -0.046 | -1 | 0.757 |
HCK |
0.689 | -0.078 | -1 | 0.770 |
FGFR2 |
0.689 | -0.049 | 3 | 0.731 |
TEC |
0.689 | -0.029 | -1 | 0.749 |
BTK |
0.688 | -0.041 | -1 | 0.777 |
FGR |
0.688 | -0.142 | 1 | 0.115 |
AXL |
0.687 | -0.071 | 3 | 0.737 |
PDGFRB |
0.687 | -0.165 | 3 | 0.783 |
KDR |
0.687 | -0.086 | 3 | 0.731 |
BMX |
0.686 | -0.045 | -1 | 0.696 |
KIT |
0.685 | -0.122 | 3 | 0.766 |
EPHB1 |
0.685 | -0.112 | 1 | 0.113 |
MERTK |
0.684 | -0.053 | 3 | 0.733 |
YANK3 |
0.684 | -0.088 | 2 | 0.345 |
SRMS |
0.684 | -0.110 | 1 | 0.103 |
FLT3 |
0.684 | -0.150 | 3 | 0.776 |
INSRR |
0.684 | -0.142 | 3 | 0.721 |
EPHB3 |
0.683 | -0.108 | -1 | 0.766 |
FER |
0.683 | -0.160 | 1 | 0.124 |
PDGFRA |
0.682 | -0.162 | 3 | 0.779 |
EPHB2 |
0.682 | -0.106 | -1 | 0.758 |
FRK |
0.681 | -0.067 | -1 | 0.796 |
WEE1_TYR |
0.681 | -0.071 | -1 | 0.679 |
ALK |
0.680 | -0.112 | 3 | 0.713 |
DDR2 |
0.680 | -0.035 | 3 | 0.700 |
MET |
0.680 | -0.116 | 3 | 0.747 |
EPHA1 |
0.679 | -0.073 | 3 | 0.729 |
EPHA4 |
0.678 | -0.104 | 2 | 0.708 |
LTK |
0.678 | -0.102 | 3 | 0.728 |
FGFR3 |
0.676 | -0.072 | 3 | 0.706 |
FYN |
0.675 | -0.080 | -1 | 0.713 |
LYN |
0.674 | -0.089 | 3 | 0.713 |
PTK2B |
0.674 | -0.067 | -1 | 0.747 |
ERBB2 |
0.674 | -0.145 | 1 | 0.128 |
EPHA7 |
0.674 | -0.102 | 2 | 0.707 |
PTK6 |
0.672 | -0.159 | -1 | 0.697 |
FLT4 |
0.672 | -0.148 | 3 | 0.718 |
NTRK2 |
0.672 | -0.177 | 3 | 0.712 |
MUSK |
0.672 | -0.101 | 1 | 0.089 |
FLT1 |
0.671 | -0.154 | -1 | 0.697 |
NTRK1 |
0.671 | -0.193 | -1 | 0.714 |
INSR |
0.670 | -0.162 | 3 | 0.714 |
CK1A |
0.670 | -0.095 | -3 | 0.370 |
NTRK3 |
0.669 | -0.144 | -1 | 0.673 |
SRC |
0.669 | -0.094 | -1 | 0.727 |
EGFR |
0.667 | -0.115 | 1 | 0.107 |
MATK |
0.665 | -0.114 | -1 | 0.638 |
EPHA3 |
0.665 | -0.141 | 2 | 0.676 |
EPHA8 |
0.664 | -0.118 | -1 | 0.720 |
FGFR4 |
0.662 | -0.114 | -1 | 0.680 |
EPHA5 |
0.661 | -0.136 | 2 | 0.686 |
CSK |
0.661 | -0.148 | 2 | 0.713 |
CK1G3 |
0.655 | -0.085 | -3 | 0.321 |
EPHA2 |
0.654 | -0.130 | -1 | 0.696 |
ERBB4 |
0.654 | -0.104 | 1 | 0.101 |
PTK2 |
0.652 | -0.109 | -1 | 0.638 |
IGF1R |
0.651 | -0.161 | 3 | 0.648 |
SYK |
0.649 | -0.127 | -1 | 0.637 |
YANK2 |
0.649 | -0.109 | 2 | 0.362 |
FES |
0.644 | -0.122 | -1 | 0.664 |
ZAP70 |
0.643 | -0.088 | -1 | 0.555 |
CK1G2 |
0.626 | -0.102 | -3 | 0.422 |