Motif 699 (n=89)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NE02 | BTBD17 | S46 | ochoa | BTB/POZ domain-containing protein 17 (Galectin-3-binding protein-like) | None |
| A8K0Z3 | WASHC1 | S217 | ochoa | WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}. |
| A8MWX3 | WASH4P | S230 | ochoa | Putative WAS protein family homolog 4 (Protein FAM39CP) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| C4AMC7 | WASH3P | S215 | ochoa | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
| E9PLD3 | None | S65 | ochoa | Uncharacterized protein | None |
| E9PRG8 | C11orf98 | S65 | ochoa | Uncharacterized protein C11orf98 | None |
| O15350 | TP73 | S388 | psp | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}. |
| O43502 | RAD51C | S20 | ochoa | DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2) | Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. {ECO:0000269|PubMed:14716019, ECO:0000269|PubMed:16215984, ECO:0000269|PubMed:16395335, ECO:0000269|PubMed:19451272, ECO:0000269|PubMed:19783859, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}. |
| O60664 | PLIN3 | S375 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O94956 | SLCO2B1 | S688 | ochoa | Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Organic anion transporting polypeptide 2B1) (OATP2B1) (Solute carrier family 21 member 9) | Mediates the Na(+)-independent transport of steroid sulfate conjugates and other specific organic anions (PubMed:10873595, PubMed:11159893, PubMed:11932330, PubMed:12724351, PubMed:14610227, PubMed:16908597, PubMed:18501590, PubMed:20507927, PubMed:22201122, PubMed:23531488, PubMed:25132355, PubMed:26383540, PubMed:27576593, PubMed:28408210, PubMed:29871943, PubMed:34628357). Responsible for the transport of estrone 3-sulfate (E1S) through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S) (PubMed:11932330, PubMed:12409283). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver (PubMed:11159893). Mediates the intestinal uptake of sulfated steroids (PubMed:12724351, PubMed:28408210). Mediates the uptake of the neurosteroids DHEA-S and pregnenolone sulfate (PregS) into the endothelial cells of the blood-brain barrier as the first step to enter the brain (PubMed:16908597, PubMed:25132355). Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May act as a heme transporter that promotes cellular iron availability via heme oxygenase/HMOX2 and independently of TFRC (PubMed:35714613). Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (PubMed:26383540). Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L-thyroxine, leukotriene C4 and thromboxane B2 (PubMed:10873595, PubMed:14610227, PubMed:19129463, PubMed:29871943, Ref.25). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:14610227, PubMed:19129463, PubMed:22201122). The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound (PubMed:19129463, PubMed:20507927, PubMed:26277985). Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions (PubMed:19129463). Cytoplasmic glutamate may also act as counteranion in the placenta (PubMed:26277985). An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) (PubMed:20507927). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:14610227, ECO:0000269|PubMed:16908597, ECO:0000269|PubMed:18501590, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20507927, ECO:0000269|PubMed:22201122, ECO:0000269|PubMed:23531488, ECO:0000269|PubMed:25132355, ECO:0000269|PubMed:26277985, ECO:0000269|PubMed:26383540, ECO:0000269|PubMed:27576593, ECO:0000269|PubMed:29871943, ECO:0000269|PubMed:34628357, ECO:0000269|PubMed:35714613, ECO:0000269|Ref.25, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 3]: Has estrone 3-sulfate (E1S) transport activity comparable with the full-length isoform 1. {ECO:0000269|PubMed:23531488}. |
| O95400 | CD2BP2 | S195 | ochoa | CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}. |
| P02647 | APOA1 | S191 | ochoa | Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}. |
| P06239 | LCK | S158 | ochoa|psp | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P0C0S8 | H2AC11 | S20 | ochoa | Histone H2A type 1 (H2A.1) (Histone H2A/ptl) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P0DPH7 | TUBA3C | Y262 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | Y262 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P11142 | HSPA8 | S329 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11532 | DMD | S2437 | ochoa | Dystrophin | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}. |
| P19447 | ERCC3 | S686 | ochoa | General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) | ATP-dependent 3'-5' DNA helicase/translocase (PubMed:17466626, PubMed:27193682, PubMed:33902107, PubMed:8465201, PubMed:8663148). Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (PubMed:27193682, PubMed:33902107). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex (PubMed:10024882, PubMed:17466626, PubMed:8157004, PubMed:8465201). When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor (PubMed:10024882, PubMed:17466626). In transcription, TFIIH has an essential role in transcription initiation (PubMed:30894545, PubMed:8157004). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:17466626, PubMed:2111438, PubMed:8157004). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA (PubMed:31253769, PubMed:33902107). XPA retains XPB/ERCC3 at the 5' end of a DNA bubble (mimicking DNA damage) (PubMed:31253769). {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:17466626, ECO:0000269|PubMed:30894545, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:33902107, ECO:0000269|PubMed:7724549, ECO:0000269|PubMed:8157004, ECO:0000269|PubMed:8663148, ECO:0000305|PubMed:8465201}. |
| P19971 | TYMP | S364 | ochoa | Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) | May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:1590793}. |
| P20671 | H2AC7 | S20 | ochoa | Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P21127 | CDK11B | Y594 | ochoa | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P23246 | SFPQ | S379 | ochoa | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
| P25963 | NFKBIA | S262 | psp | NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:36651806, PubMed:7479976). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7479976, PubMed:7628694, PubMed:7796813, PubMed:7878466). {ECO:0000269|PubMed:1493333, ECO:0000269|PubMed:36651806, ECO:0000269|PubMed:7479976, ECO:0000269|PubMed:7628694, ECO:0000269|PubMed:7796813, ECO:0000269|PubMed:7878466}. |
| P35749 | MYH11 | S1720 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P40227 | CCT6A | S428 | ochoa | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P41229 | KDM5C | S897 | ochoa | Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:28262558}. |
| P49327 | FASN | S1174 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49591 | SARS1 | S101 | psp | Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817, PubMed:9431993). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:9431993). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423847, PubMed:19423848, PubMed:24940000). {ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848, ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229, ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817, ECO:0000269|PubMed:9431993}. |
| P50748 | KNTC1 | S1045 | ochoa | Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| P52948 | NUP98 | S494 | psp | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P68363 | TUBA1B | Y262 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | Y262 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q07065 | CKAP4 | S461 | ochoa | Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63) | Mediates the anchoring of the endoplasmic reticulum to microtubules. {ECO:0000269|PubMed:15703217}.; FUNCTION: High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells. {ECO:0000269|PubMed:17030514, ECO:0000269|PubMed:19144824}. |
| Q08379 | GOLGA2 | S123 | ochoa | Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) | Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940, ECO:0000305|PubMed:26363069}. |
| Q13118 | KLF10 | S184 | ochoa | Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}. |
| Q13796 | SHROOM2 | S1524 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q15149 | PLEC | S476 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15149 | PLEC | S3461 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15785 | TOMM34 | S280 | ochoa | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
| Q16822 | PCK2 | S304 | ochoa | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2) | Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:28955899). Can play an active role in glyceroneogenesis and gluconeogenesis (PubMed:28955899). {ECO:0000269|PubMed:28955899}. |
| Q2QGD7 | ZXDC | S34 | ochoa | Zinc finger protein ZXDC (ZXD-like zinc finger protein) | Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:17696781}. |
| Q68EM7 | ARHGAP17 | S162 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6IQ23 | PLEKHA7 | S448 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6P1M0 | SLC27A4 | S555 | ochoa | Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 4) (Very long-chain acyl-CoA synthetase 4) (ACSVL4) (EC 6.2.1.-) | Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes (PubMed:10518211, PubMed:12556534, PubMed:20448275, PubMed:21395585, PubMed:22022213). Appears to be the principal fatty acid transporter in small intestinal enterocytes (PubMed:20448275). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:22022213, PubMed:24269233). Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:21395585). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). {ECO:0000250|UniProtKB:Q91VE0, ECO:0000269|PubMed:10518211, ECO:0000269|PubMed:12556534, ECO:0000269|PubMed:20448275, ECO:0000269|PubMed:21395585, ECO:0000269|PubMed:22022213, ECO:0000269|PubMed:24269233}. |
| Q6PEY2 | TUBA3E | Y262 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6VEQ5 | WASH2P | S217 | ochoa | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
| Q71U36 | TUBA1A | Y262 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z2Z1 | TICRR | S1763 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q8N441 | FGFRL1 | S452 | ochoa | Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5) | Has a negative effect on cell proliferation. {ECO:0000250}. |
| Q8NCF5 | NFATC2IP | S127 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8WXF1 | PSPC1 | S164 | ochoa | Paraspeckle component 1 (Paraspeckle protein 1) | RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8R326, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}. |
| Q92619 | ARHGAP45 | S880 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q96KK5 | H2AC12 | S20 | ochoa | Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96T58 | SPEN | S1358 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99623 | PHB2 | S119 | ochoa | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}. |
| Q99623 | PHB2 | S161 | ochoa | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}. |
| Q99698 | LYST | S2632 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q99878 | H2AC14 | S20 | ochoa | Histone H2A type 1-J (Histone H2A/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9BQE3 | TUBA1C | Y262 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BY66 | KDM5D | S884 | ochoa | Lysine-specific demethylase 5D (EC 1.14.11.67) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY) ([histone H3]-trimethyl-L-lysine(4) demethylase 5D) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. {ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:17351630, ECO:0000269|PubMed:26747897, ECO:0000269|PubMed:27185910, ECO:0000269|PubMed:27427228, ECO:0000269|PubMed:27477906}. |
| Q9H0K1 | SIK2 | S343 | ochoa|psp | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
| Q9H8M2 | BRD9 | S138 | ochoa | Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) | Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). {ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:32457312}. |
| Q9HCX4 | TRPC7 | S714 | psp | Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7) | Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion. {ECO:0000250|UniProtKB:Q9WVC5}. |
| Q9NQA3 | WASH6P | S199 | ochoa | WAS protein family homolog 6 (Protein FAM39A) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| Q9NY65 | TUBA8 | Y262 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9P0J7 | KCMF1 | S220 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P206 | NHSL3 | S418 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9UI14 | RABAC1 | S28 | ochoa | Prenylated Rab acceptor protein 1 (PRA1 family protein 1) | General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI. {ECO:0000250|UniProtKB:O35394}. |
| Q9UKS6 | PACSIN3 | S181 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
| Q9ULT0 | TTC7A | S182 | ochoa | Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. |
| Q9ULV0 | MYO5B | S1446 | ochoa | Unconventional myosin-Vb | May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes (PubMed:34816459). {ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:34816459}. |
| Q9UMS6 | SYNPO2 | S274 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9Y490 | TLN1 | S1260 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4D8 | HECTD4 | S1716 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q13155 | AIMP2 | S48 | Sugiyama | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) | Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:19131329}. |
| Q13164 | MAPK7 | S562 | Sugiyama | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| P04908 | H2AC4 | S20 | Sugiyama | Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P16104 | H2AX | S20 | Sugiyama | Histone H2AX (H2a/x) (Histone H2A.X) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:26438602}. |
| Q16777 | H2AC20 | S20 | Sugiyama | Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6FI13 | H2AC18 | S20 | Sugiyama | Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q7L7L0 | H2AC25 | S20 | Sugiyama | Histone H2A type 3 (H2A-clustered histone 25) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q8IUE6 | H2AC21 | S20 | Sugiyama | Histone H2A type 2-B (H2A-clustered histone 21) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q93077 | H2AC6 | S20 | Sugiyama | Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96QV6 | H2AC1 | S20 | Sugiyama | Histone H2A type 1-A (H2A-clustered histone 1) (Histone H2A/r) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9BTM1 | H2AJ | S20 | Sugiyama | Histone H2A.J (H2a/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q15596 | NCOA2 | S269 | Sugiyama | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q16512 | PKN1 | S156 | Sugiyama | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| P62495 | ETF1 | S239 | Sugiyama | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793, PubMed:7990965). The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:26245381, PubMed:27863242, PubMed:36638793). ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:26245381, PubMed:27863242, PubMed:36638793). Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:10676813, PubMed:16777602, PubMed:26245381, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:10676813, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:26245381, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:7990965}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9609690 | HCMV Early Events | 1.110223e-16 | 15.955 |
| R-HSA-9609646 | HCMV Infection | 1.110223e-16 | 15.955 |
| R-HSA-3214858 | RMTs methylate histone arginines | 1.110223e-16 | 15.955 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.220446e-16 | 15.654 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 6.106227e-15 | 14.214 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.785061e-14 | 13.320 |
| R-HSA-68886 | M Phase | 4.607426e-14 | 13.337 |
| R-HSA-3214815 | HDACs deacetylate histones | 2.694511e-13 | 12.570 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 6.109557e-13 | 12.214 |
| R-HSA-4839726 | Chromatin organization | 7.766010e-13 | 12.110 |
| R-HSA-69278 | Cell Cycle, Mitotic | 8.546497e-13 | 12.068 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.712297e-12 | 11.766 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.431388e-12 | 11.614 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.429146e-12 | 11.465 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.093503e-12 | 11.388 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 4.690803e-12 | 11.329 |
| R-HSA-3214847 | HATs acetylate histones | 4.871881e-12 | 11.312 |
| R-HSA-9610379 | HCMV Late Events | 4.448664e-12 | 11.352 |
| R-HSA-5689603 | UCH proteinases | 5.749845e-12 | 11.240 |
| R-HSA-1640170 | Cell Cycle | 9.506951e-12 | 11.022 |
| R-HSA-171306 | Packaging Of Telomere Ends | 4.155054e-11 | 10.381 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 4.155054e-11 | 10.381 |
| R-HSA-68875 | Mitotic Prophase | 4.620493e-11 | 10.335 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 5.249767e-11 | 10.280 |
| R-HSA-5334118 | DNA methylation | 6.587120e-11 | 10.181 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.252995e-10 | 9.902 |
| R-HSA-912446 | Meiotic recombination | 1.396184e-10 | 9.855 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.534760e-10 | 9.814 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.534760e-10 | 9.814 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.616125e-10 | 9.792 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.267152e-10 | 9.645 |
| R-HSA-190861 | Gap junction assembly | 2.267152e-10 | 9.645 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.058065e-10 | 9.687 |
| R-HSA-211000 | Gene Silencing by RNA | 2.229231e-10 | 9.652 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.267152e-10 | 9.645 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.285818e-10 | 9.483 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.929710e-10 | 9.406 |
| R-HSA-110331 | Cleavage of the damaged purine | 3.929710e-10 | 9.406 |
| R-HSA-2262752 | Cellular responses to stress | 4.323395e-10 | 9.364 |
| R-HSA-73927 | Depurination | 4.680393e-10 | 9.330 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.928057e-10 | 9.307 |
| R-HSA-9663891 | Selective autophagy | 5.439015e-10 | 9.264 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 6.562230e-10 | 9.183 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 6.562230e-10 | 9.183 |
| R-HSA-9646399 | Aggrephagy | 6.562230e-10 | 9.183 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 7.364518e-10 | 9.133 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.657425e-10 | 9.116 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 7.727546e-10 | 9.112 |
| R-HSA-391251 | Protein folding | 8.770049e-10 | 9.057 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 9.068253e-10 | 9.042 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.976867e-10 | 9.001 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 1.060616e-09 | 8.974 |
| R-HSA-73928 | Depyrimidination | 1.060616e-09 | 8.974 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.252740e-09 | 8.902 |
| R-HSA-9710421 | Defective pyroptosis | 1.236525e-09 | 8.908 |
| R-HSA-190828 | Gap junction trafficking | 1.437181e-09 | 8.842 |
| R-HSA-774815 | Nucleosome assembly | 1.665463e-09 | 8.778 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.665463e-09 | 8.778 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.748635e-09 | 8.757 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.924516e-09 | 8.716 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 2.217769e-09 | 8.654 |
| R-HSA-437239 | Recycling pathway of L1 | 2.217769e-09 | 8.654 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.922136e-09 | 8.534 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.963220e-09 | 8.528 |
| R-HSA-9824446 | Viral Infection Pathways | 3.516592e-09 | 8.454 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.625887e-09 | 8.441 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.403503e-09 | 8.356 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.415197e-09 | 8.355 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.415197e-09 | 8.355 |
| R-HSA-9833482 | PKR-mediated signaling | 4.415197e-09 | 8.355 |
| R-HSA-1221632 | Meiotic synapsis | 4.928491e-09 | 8.307 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.928491e-09 | 8.307 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.351389e-09 | 8.272 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.585375e-09 | 8.253 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.316649e-09 | 8.200 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.457319e-09 | 8.190 |
| R-HSA-1500620 | Meiosis | 7.081859e-09 | 8.150 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 9.029101e-09 | 8.044 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.014150e-08 | 7.994 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.135146e-08 | 7.945 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.227511e-08 | 7.911 |
| R-HSA-983189 | Kinesins | 1.135146e-08 | 7.945 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.135146e-08 | 7.945 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.417268e-08 | 7.849 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.417268e-08 | 7.849 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.417268e-08 | 7.849 |
| R-HSA-5688426 | Deubiquitination | 1.458538e-08 | 7.836 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.167187e-08 | 7.664 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.333454e-08 | 7.632 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.656066e-08 | 7.576 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.237238e-08 | 7.490 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.566798e-08 | 7.448 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 3.566798e-08 | 7.448 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.237238e-08 | 7.490 |
| R-HSA-597592 | Post-translational protein modification | 3.805316e-08 | 7.420 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.313500e-08 | 7.365 |
| R-HSA-1632852 | Macroautophagy | 5.278871e-08 | 7.277 |
| R-HSA-977225 | Amyloid fiber formation | 8.806881e-08 | 7.055 |
| R-HSA-373760 | L1CAM interactions | 1.200410e-07 | 6.921 |
| R-HSA-9612973 | Autophagy | 1.278999e-07 | 6.893 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.558769e-07 | 6.807 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.685117e-07 | 6.773 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.926609e-07 | 6.715 |
| R-HSA-73884 | Base Excision Repair | 1.964385e-07 | 6.707 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 2.118309e-07 | 6.674 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.225258e-07 | 6.653 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.225258e-07 | 6.653 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.225258e-07 | 6.653 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.643752e-07 | 6.578 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.515373e-07 | 6.454 |
| R-HSA-1474165 | Reproduction | 3.150917e-07 | 6.502 |
| R-HSA-157579 | Telomere Maintenance | 3.768217e-07 | 6.424 |
| R-HSA-392499 | Metabolism of proteins | 3.980856e-07 | 6.400 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.638275e-07 | 6.334 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.279553e-07 | 6.277 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.279553e-07 | 6.277 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.279553e-07 | 6.277 |
| R-HSA-69275 | G2/M Transition | 5.647810e-07 | 6.248 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.161969e-07 | 6.210 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.414579e-07 | 6.193 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.414579e-07 | 6.193 |
| R-HSA-68877 | Mitotic Prometaphase | 7.630635e-07 | 6.117 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.620974e-07 | 6.064 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 8.770253e-07 | 6.057 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.115295e-06 | 5.953 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.210124e-06 | 5.917 |
| R-HSA-5620924 | Intraflagellar transport | 1.415879e-06 | 5.849 |
| R-HSA-73886 | Chromosome Maintenance | 1.964415e-06 | 5.707 |
| R-HSA-68882 | Mitotic Anaphase | 1.978837e-06 | 5.704 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.054047e-06 | 5.687 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.187856e-06 | 5.660 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.187856e-06 | 5.660 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.204416e-06 | 5.494 |
| R-HSA-5663205 | Infectious disease | 2.583805e-06 | 5.588 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.842831e-06 | 5.415 |
| R-HSA-2559583 | Cellular Senescence | 3.930129e-06 | 5.406 |
| R-HSA-913531 | Interferon Signaling | 6.824452e-06 | 5.166 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.423878e-06 | 5.074 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.423878e-06 | 5.074 |
| R-HSA-422475 | Axon guidance | 8.873893e-06 | 5.052 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.051579e-06 | 5.043 |
| R-HSA-69306 | DNA Replication | 1.088912e-05 | 4.963 |
| R-HSA-1643685 | Disease | 1.674456e-05 | 4.776 |
| R-HSA-9675108 | Nervous system development | 1.792394e-05 | 4.747 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.097006e-05 | 4.678 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.300705e-05 | 4.638 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.389103e-05 | 4.622 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.478708e-05 | 4.606 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.478708e-05 | 4.606 |
| R-HSA-162582 | Signal Transduction | 2.778127e-05 | 4.556 |
| R-HSA-8939211 | ESR-mediated signaling | 2.943202e-05 | 4.531 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.540830e-05 | 4.451 |
| R-HSA-5617833 | Cilium Assembly | 4.491609e-05 | 4.348 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.883375e-05 | 4.311 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.088219e-05 | 4.293 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.468025e-05 | 4.262 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.567205e-05 | 4.183 |
| R-HSA-1280218 | Adaptive Immune System | 7.306947e-05 | 4.136 |
| R-HSA-446728 | Cell junction organization | 9.095394e-05 | 4.041 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.239761e-05 | 4.034 |
| R-HSA-418990 | Adherens junctions interactions | 1.100196e-04 | 3.959 |
| R-HSA-73894 | DNA Repair | 1.131226e-04 | 3.946 |
| R-HSA-157118 | Signaling by NOTCH | 2.001468e-04 | 3.699 |
| R-HSA-1500931 | Cell-Cell communication | 2.217657e-04 | 3.654 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.418344e-04 | 3.616 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.578579e-04 | 3.589 |
| R-HSA-421270 | Cell-cell junction organization | 2.640460e-04 | 3.578 |
| R-HSA-5358351 | Signaling by Hedgehog | 3.931436e-04 | 3.405 |
| R-HSA-1266738 | Developmental Biology | 6.095657e-04 | 3.215 |
| R-HSA-195721 | Signaling by WNT | 7.523650e-04 | 3.124 |
| R-HSA-199991 | Membrane Trafficking | 7.741105e-04 | 3.111 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.330652e-04 | 3.030 |
| R-HSA-109582 | Hemostasis | 1.211795e-03 | 2.917 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.450234e-03 | 2.839 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.567588e-03 | 2.805 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.567588e-03 | 2.805 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.569377e-03 | 2.804 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.574784e-03 | 2.803 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.819761e-03 | 2.740 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.819761e-03 | 2.740 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.954780e-03 | 2.709 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.954780e-03 | 2.709 |
| R-HSA-168256 | Immune System | 1.966785e-03 | 2.706 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.095886e-03 | 2.679 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.243171e-03 | 2.649 |
| R-HSA-9613354 | Lipophagy | 2.516866e-03 | 2.599 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.556650e-03 | 2.592 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.723020e-03 | 2.565 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.895925e-03 | 2.538 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.895925e-03 | 2.538 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 2.942172e-03 | 2.531 |
| R-HSA-112316 | Neuronal System | 3.039627e-03 | 2.517 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.075449e-03 | 2.512 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.075449e-03 | 2.512 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.075449e-03 | 2.512 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.261671e-03 | 2.487 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 3.398771e-03 | 2.469 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.295953e-03 | 2.367 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.523951e-03 | 2.344 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 4.952471e-03 | 2.305 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.191102e-03 | 2.285 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 6.137725e-03 | 2.212 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 7.520749e-03 | 2.124 |
| R-HSA-194441 | Metabolism of non-coding RNA | 8.165213e-03 | 2.088 |
| R-HSA-191859 | snRNP Assembly | 8.165213e-03 | 2.088 |
| R-HSA-70326 | Glucose metabolism | 8.634332e-03 | 2.064 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 8.841267e-03 | 2.053 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 8.853555e-03 | 2.053 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 8.853555e-03 | 2.053 |
| R-HSA-6784531 | tRNA processing in the nucleus | 9.191242e-03 | 2.037 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 9.549233e-03 | 2.020 |
| R-HSA-3371556 | Cellular response to heat stress | 9.561768e-03 | 2.019 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.029836e-02 | 1.987 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 1.209862e-02 | 1.917 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.357722e-02 | 1.867 |
| R-HSA-380287 | Centrosome maturation | 1.448201e-02 | 1.839 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.357722e-02 | 1.867 |
| R-HSA-3214842 | HDMs demethylate histones | 1.558645e-02 | 1.807 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.639216e-02 | 1.785 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.448201e-02 | 1.839 |
| R-HSA-3295583 | TRP channels | 1.654332e-02 | 1.781 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.683399e-02 | 1.774 |
| R-HSA-162906 | HIV Infection | 1.782051e-02 | 1.749 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.791326e-02 | 1.747 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 1.809348e-02 | 1.742 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.955961e-02 | 1.709 |
| R-HSA-162587 | HIV Life Cycle | 2.250470e-02 | 1.648 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.395210e-02 | 1.621 |
| R-HSA-198765 | Signalling to ERK5 | 2.405233e-02 | 1.619 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.505315e-02 | 1.601 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 2.621901e-02 | 1.581 |
| R-HSA-5619102 | SLC transporter disorders | 2.686157e-02 | 1.571 |
| R-HSA-5682113 | Defective ABCA1 causes TGD | 2.997539e-02 | 1.523 |
| R-HSA-70171 | Glycolysis | 3.069951e-02 | 1.513 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.365875e-02 | 1.473 |
| R-HSA-5260271 | Diseases of Immune System | 3.365875e-02 | 1.473 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.418443e-02 | 1.466 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.503807e-02 | 1.455 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 3.586287e-02 | 1.445 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 3.586287e-02 | 1.445 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.732018e-02 | 1.428 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.765131e-02 | 1.424 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.809749e-02 | 1.419 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.888308e-02 | 1.410 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.888308e-02 | 1.410 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.047897e-02 | 1.393 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.128925e-02 | 1.384 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 4.171497e-02 | 1.380 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.376911e-02 | 1.359 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 4.753191e-02 | 1.323 |
| R-HSA-8964011 | HDL clearance | 5.331391e-02 | 1.273 |
| R-HSA-164944 | Nef and signal transduction | 5.331391e-02 | 1.273 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.370342e-02 | 1.270 |
| R-HSA-114608 | Platelet degranulation | 5.629639e-02 | 1.250 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 5.906115e-02 | 1.229 |
| R-HSA-5619108 | Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) | 5.906115e-02 | 1.229 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 5.906115e-02 | 1.229 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 5.906115e-02 | 1.229 |
| R-HSA-447041 | CHL1 interactions | 5.906115e-02 | 1.229 |
| R-HSA-446107 | Type I hemidesmosome assembly | 6.477386e-02 | 1.189 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 6.477386e-02 | 1.189 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 7.609650e-02 | 1.119 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 8.170682e-02 | 1.088 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 8.728343e-02 | 1.059 |
| R-HSA-202670 | ERKs are inactivated | 8.728343e-02 | 1.059 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 9.833627e-02 | 1.007 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.092566e-01 | 0.962 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.092566e-01 | 0.962 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.146676e-01 | 0.941 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 7.000509e-02 | 1.155 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 7.000509e-02 | 1.155 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 7.517507e-02 | 1.124 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.123854e-01 | 0.949 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.123854e-01 | 0.949 |
| R-HSA-1989781 | PPARA activates gene expression | 8.928032e-02 | 1.049 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 9.163759e-02 | 1.038 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.223175e-01 | 0.913 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 8.728343e-02 | 1.059 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.200460e-01 | 0.921 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 9.833627e-02 | 1.007 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 9.833627e-02 | 1.007 |
| R-HSA-8963901 | Chylomicron remodeling | 9.833627e-02 | 1.007 |
| R-HSA-8963896 | HDL assembly | 1.038129e-01 | 0.984 |
| R-HSA-8963888 | Chylomicron assembly | 8.170682e-02 | 1.088 |
| R-HSA-8949664 | Processing of SMDT1 | 9.833627e-02 | 1.007 |
| R-HSA-3000471 | Scavenging by Class B Receptors | 1.200460e-01 | 0.921 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.100760e-01 | 0.958 |
| R-HSA-209560 | NF-kB is activated and signals survival | 8.728343e-02 | 1.059 |
| R-HSA-804914 | Transport of fatty acids | 1.038129e-01 | 0.984 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.038129e-01 | 0.984 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 8.170682e-02 | 1.088 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.084751e-01 | 0.965 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.123874e-02 | 1.090 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.038129e-01 | 0.984 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 9.282651e-02 | 1.032 |
| R-HSA-379724 | tRNA Aminoacylation | 6.495922e-02 | 1.187 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 9.833627e-02 | 1.007 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.038129e-01 | 0.984 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 7.045224e-02 | 1.152 |
| R-HSA-202424 | Downstream TCR signaling | 1.223175e-01 | 0.913 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.092566e-01 | 0.962 |
| R-HSA-9635465 | Suppression of apoptosis | 8.170682e-02 | 1.088 |
| R-HSA-210990 | PECAM1 interactions | 8.170682e-02 | 1.088 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.038129e-01 | 0.984 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.313281e-02 | 1.200 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.928032e-02 | 1.049 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.146676e-01 | 0.941 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.146676e-01 | 0.941 |
| R-HSA-8876725 | Protein methylation | 1.092566e-01 | 0.962 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.146676e-01 | 0.941 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 7.045224e-02 | 1.152 |
| R-HSA-168255 | Influenza Infection | 1.205205e-01 | 0.919 |
| R-HSA-9754706 | Atorvastatin ADME | 1.146676e-01 | 0.941 |
| R-HSA-9707616 | Heme signaling | 6.830904e-02 | 1.166 |
| R-HSA-9020558 | Interleukin-2 signaling | 8.170682e-02 | 1.088 |
| R-HSA-373755 | Semaphorin interactions | 7.000509e-02 | 1.155 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.461251e-02 | 1.127 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 8.225103e-02 | 1.085 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 9.509779e-02 | 1.022 |
| R-HSA-109581 | Apoptosis | 9.764332e-02 | 1.010 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.143543e-01 | 0.942 |
| R-HSA-72306 | tRNA processing | 1.088444e-01 | 0.963 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.253921e-01 | 0.902 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.253921e-01 | 0.902 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.253921e-01 | 0.902 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.263492e-01 | 0.898 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.359881e-01 | 0.866 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.359881e-01 | 0.866 |
| R-HSA-8964058 | HDL remodeling | 1.359881e-01 | 0.866 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.359881e-01 | 0.866 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.367707e-01 | 0.864 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.412383e-01 | 0.850 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.412383e-01 | 0.850 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.412383e-01 | 0.850 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.412383e-01 | 0.850 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 1.412383e-01 | 0.850 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.412383e-01 | 0.850 |
| R-HSA-9629569 | Protein hydroxylation | 1.412383e-01 | 0.850 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 1.427788e-01 | 0.845 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.427788e-01 | 0.845 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.427788e-01 | 0.845 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.427788e-01 | 0.845 |
| R-HSA-198753 | ERK/MAPK targets | 1.464569e-01 | 0.834 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.469554e-01 | 0.833 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 1.516442e-01 | 0.819 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.553830e-01 | 0.809 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.568002e-01 | 0.805 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.568002e-01 | 0.805 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 1.568002e-01 | 0.805 |
| R-HSA-5357801 | Programmed Cell Death | 1.580686e-01 | 0.801 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 1.619252e-01 | 0.791 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 1.619252e-01 | 0.791 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 1.619252e-01 | 0.791 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.619252e-01 | 0.791 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 1.619252e-01 | 0.791 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.660447e-01 | 0.780 |
| R-HSA-6798695 | Neutrophil degranulation | 1.669827e-01 | 0.777 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 1.670194e-01 | 0.777 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 1.670194e-01 | 0.777 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 1.670194e-01 | 0.777 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.670194e-01 | 0.777 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.670194e-01 | 0.777 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.670194e-01 | 0.777 |
| R-HSA-397014 | Muscle contraction | 1.683421e-01 | 0.774 |
| R-HSA-202403 | TCR signaling | 1.703453e-01 | 0.769 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.720830e-01 | 0.764 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.720830e-01 | 0.764 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.720830e-01 | 0.764 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.720830e-01 | 0.764 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.771160e-01 | 0.752 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 1.771160e-01 | 0.752 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.790021e-01 | 0.747 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.790021e-01 | 0.747 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 1.811771e-01 | 0.742 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.821188e-01 | 0.740 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 1.821188e-01 | 0.740 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.821188e-01 | 0.740 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 1.821188e-01 | 0.740 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 1.821188e-01 | 0.740 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 1.821188e-01 | 0.740 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.821188e-01 | 0.740 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 1.870915e-01 | 0.728 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 1.870915e-01 | 0.728 |
| R-HSA-73614 | Pyrimidine salvage | 1.870915e-01 | 0.728 |
| R-HSA-72086 | mRNA Capping | 1.920342e-01 | 0.717 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.920342e-01 | 0.717 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.920342e-01 | 0.717 |
| R-HSA-418360 | Platelet calcium homeostasis | 1.920342e-01 | 0.717 |
| R-HSA-5693538 | Homology Directed Repair | 1.921105e-01 | 0.716 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.925181e-01 | 0.716 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.943080e-01 | 0.712 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.943080e-01 | 0.712 |
| R-HSA-2424491 | DAP12 signaling | 1.969472e-01 | 0.706 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 1.969472e-01 | 0.706 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 1.969472e-01 | 0.706 |
| R-HSA-114452 | Activation of BH3-only proteins | 1.969472e-01 | 0.706 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.009198e-01 | 0.697 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.009198e-01 | 0.697 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.018307e-01 | 0.695 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.066847e-01 | 0.685 |
| R-HSA-354192 | Integrin signaling | 2.115095e-01 | 0.675 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.115095e-01 | 0.675 |
| R-HSA-159418 | Recycling of bile acids and salts | 2.115095e-01 | 0.675 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.115095e-01 | 0.675 |
| R-HSA-390522 | Striated Muscle Contraction | 2.163053e-01 | 0.665 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.163053e-01 | 0.665 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 2.163053e-01 | 0.665 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 2.163053e-01 | 0.665 |
| R-HSA-189483 | Heme degradation | 2.163053e-01 | 0.665 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.210722e-01 | 0.655 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.210722e-01 | 0.655 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.210722e-01 | 0.655 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 2.210722e-01 | 0.655 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.258104e-01 | 0.646 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.258104e-01 | 0.646 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.305201e-01 | 0.637 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.305201e-01 | 0.637 |
| R-HSA-163560 | Triglyceride catabolism | 2.305201e-01 | 0.637 |
| R-HSA-8853659 | RET signaling | 2.305201e-01 | 0.637 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.305201e-01 | 0.637 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.352014e-01 | 0.629 |
| R-HSA-163685 | Integration of energy metabolism | 2.388024e-01 | 0.622 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.398545e-01 | 0.620 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.399110e-01 | 0.620 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.444796e-01 | 0.612 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.444796e-01 | 0.612 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.444796e-01 | 0.612 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.444796e-01 | 0.612 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.455365e-01 | 0.610 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.490768e-01 | 0.604 |
| R-HSA-3371568 | Attenuation phase | 2.490768e-01 | 0.604 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.490768e-01 | 0.604 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.490768e-01 | 0.604 |
| R-HSA-167169 | HIV Transcription Elongation | 2.490768e-01 | 0.604 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 2.490768e-01 | 0.604 |
| R-HSA-202433 | Generation of second messenger molecules | 2.490768e-01 | 0.604 |
| R-HSA-451927 | Interleukin-2 family signaling | 2.490768e-01 | 0.604 |
| R-HSA-9607240 | FLT3 Signaling | 2.536463e-01 | 0.596 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.567763e-01 | 0.590 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 2.581884e-01 | 0.588 |
| R-HSA-167161 | HIV Transcription Initiation | 2.581884e-01 | 0.588 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 2.581884e-01 | 0.588 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.581884e-01 | 0.588 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.581884e-01 | 0.588 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 2.581884e-01 | 0.588 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.627030e-01 | 0.581 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 2.671905e-01 | 0.573 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.671905e-01 | 0.573 |
| R-HSA-73621 | Pyrimidine catabolism | 2.671905e-01 | 0.573 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.671905e-01 | 0.573 |
| R-HSA-2172127 | DAP12 interactions | 2.716509e-01 | 0.566 |
| R-HSA-5683826 | Surfactant metabolism | 2.716509e-01 | 0.566 |
| R-HSA-373752 | Netrin-1 signaling | 2.716509e-01 | 0.566 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 2.760845e-01 | 0.559 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.760845e-01 | 0.559 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 2.760845e-01 | 0.559 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.792775e-01 | 0.554 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 2.804913e-01 | 0.552 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.804913e-01 | 0.552 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.804913e-01 | 0.552 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.804913e-01 | 0.552 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.804913e-01 | 0.552 |
| R-HSA-9675135 | Diseases of DNA repair | 2.804913e-01 | 0.552 |
| R-HSA-75153 | Apoptotic execution phase | 2.804913e-01 | 0.552 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.848716e-01 | 0.545 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.848716e-01 | 0.545 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.892255e-01 | 0.539 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 2.892255e-01 | 0.539 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.892255e-01 | 0.539 |
| R-HSA-70263 | Gluconeogenesis | 2.892255e-01 | 0.539 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.021303e-01 | 0.520 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.021303e-01 | 0.520 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.039806e-01 | 0.517 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.063802e-01 | 0.514 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.063802e-01 | 0.514 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.063802e-01 | 0.514 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.106045e-01 | 0.508 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.106045e-01 | 0.508 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.231250e-01 | 0.491 |
| R-HSA-5654736 | Signaling by FGFR1 | 3.231250e-01 | 0.491 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.231250e-01 | 0.491 |
| R-HSA-74160 | Gene expression (Transcription) | 3.235992e-01 | 0.490 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 3.293063e-01 | 0.482 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.313468e-01 | 0.480 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.354205e-01 | 0.474 |
| R-HSA-8979227 | Triglyceride metabolism | 3.354205e-01 | 0.474 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.354205e-01 | 0.474 |
| R-HSA-450294 | MAP kinase activation | 3.434944e-01 | 0.464 |
| R-HSA-211976 | Endogenous sterols | 3.434944e-01 | 0.464 |
| R-HSA-8956321 | Nucleotide salvage | 3.434944e-01 | 0.464 |
| R-HSA-445717 | Aquaporin-mediated transport | 3.434944e-01 | 0.464 |
| R-HSA-8957322 | Metabolism of steroids | 3.488836e-01 | 0.457 |
| R-HSA-8848021 | Signaling by PTK6 | 3.514711e-01 | 0.454 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.514711e-01 | 0.454 |
| R-HSA-449147 | Signaling by Interleukins | 3.574670e-01 | 0.447 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.593520e-01 | 0.444 |
| R-HSA-983712 | Ion channel transport | 3.616465e-01 | 0.442 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.671380e-01 | 0.435 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.671380e-01 | 0.435 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 3.671380e-01 | 0.435 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.682006e-01 | 0.434 |
| R-HSA-167172 | Transcription of the HIV genome | 3.709958e-01 | 0.431 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.786418e-01 | 0.422 |
| R-HSA-204005 | COPII-mediated vesicle transport | 3.786418e-01 | 0.422 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 3.786418e-01 | 0.422 |
| R-HSA-448424 | Interleukin-17 signaling | 3.786418e-01 | 0.422 |
| R-HSA-975634 | Retinoid metabolism and transport | 3.824302e-01 | 0.417 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.824302e-01 | 0.417 |
| R-HSA-189445 | Metabolism of porphyrins | 3.824302e-01 | 0.417 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.861957e-01 | 0.413 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.861957e-01 | 0.413 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.861957e-01 | 0.413 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.861957e-01 | 0.413 |
| R-HSA-9749641 | Aspirin ADME | 3.899386e-01 | 0.409 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.902584e-01 | 0.409 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.936588e-01 | 0.405 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.936588e-01 | 0.405 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 3.936588e-01 | 0.405 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.973565e-01 | 0.401 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.973565e-01 | 0.401 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 3.973565e-01 | 0.401 |
| R-HSA-8852135 | Protein ubiquitination | 3.973565e-01 | 0.401 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.083164e-01 | 0.389 |
| R-HSA-5619084 | ABC transporter disorders | 4.083164e-01 | 0.389 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 4.083164e-01 | 0.389 |
| R-HSA-382551 | Transport of small molecules | 4.098922e-01 | 0.387 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.155132e-01 | 0.381 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 4.190790e-01 | 0.378 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.190790e-01 | 0.378 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.190790e-01 | 0.378 |
| R-HSA-8953854 | Metabolism of RNA | 4.217122e-01 | 0.375 |
| R-HSA-9748784 | Drug ADME | 4.259022e-01 | 0.371 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.261462e-01 | 0.370 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.296478e-01 | 0.367 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.331282e-01 | 0.363 |
| R-HSA-168249 | Innate Immune System | 4.388127e-01 | 0.358 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4.400262e-01 | 0.357 |
| R-HSA-112310 | Neurotransmitter release cycle | 4.535738e-01 | 0.343 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.602255e-01 | 0.337 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 4.635212e-01 | 0.334 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.635212e-01 | 0.334 |
| R-HSA-9679506 | SARS-CoV Infections | 4.665198e-01 | 0.331 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.700530e-01 | 0.328 |
| R-HSA-1474290 | Collagen formation | 4.700530e-01 | 0.328 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.732893e-01 | 0.325 |
| R-HSA-72764 | Eukaryotic Translation Termination | 4.765060e-01 | 0.322 |
| R-HSA-2168880 | Scavenging of heme from plasma | 4.765060e-01 | 0.322 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.797033e-01 | 0.319 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 4.797033e-01 | 0.319 |
| R-HSA-190236 | Signaling by FGFR | 4.860401e-01 | 0.313 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.891797e-01 | 0.311 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 4.891797e-01 | 0.311 |
| R-HSA-212436 | Generic Transcription Pathway | 4.914450e-01 | 0.309 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.923004e-01 | 0.308 |
| R-HSA-2408557 | Selenocysteine synthesis | 4.954022e-01 | 0.305 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.954022e-01 | 0.305 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.106320e-01 | 0.292 |
| R-HSA-418346 | Platelet homeostasis | 5.136230e-01 | 0.289 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.136230e-01 | 0.289 |
| R-HSA-416476 | G alpha (q) signalling events | 5.175037e-01 | 0.286 |
| R-HSA-72766 | Translation | 5.183273e-01 | 0.285 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.195506e-01 | 0.284 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 5.254068e-01 | 0.280 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.311923e-01 | 0.275 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.311923e-01 | 0.275 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.508971e-01 | 0.259 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.536443e-01 | 0.257 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 5.617866e-01 | 0.250 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.671329e-01 | 0.246 |
| R-HSA-69481 | G2/M Checkpoints | 5.802180e-01 | 0.236 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.827876e-01 | 0.234 |
| R-HSA-8956319 | Nucleotide catabolism | 5.853416e-01 | 0.233 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.878802e-01 | 0.231 |
| R-HSA-9843745 | Adipogenesis | 5.929113e-01 | 0.227 |
| R-HSA-9909396 | Circadian clock | 5.954041e-01 | 0.225 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.051490e-01 | 0.218 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.100462e-01 | 0.215 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.287561e-01 | 0.202 |
| R-HSA-1474244 | Extracellular matrix organization | 6.327444e-01 | 0.199 |
| R-HSA-2187338 | Visual phototransduction | 6.355408e-01 | 0.197 |
| R-HSA-166520 | Signaling by NTRKs | 6.377750e-01 | 0.195 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 6.422028e-01 | 0.192 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.465770e-01 | 0.189 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.465770e-01 | 0.189 |
| R-HSA-73887 | Death Receptor Signaling | 6.508983e-01 | 0.186 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.593846e-01 | 0.181 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.635508e-01 | 0.178 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 6.777393e-01 | 0.169 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 6.812182e-01 | 0.167 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.875098e-01 | 0.163 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 6.951145e-01 | 0.158 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.256372e-01 | 0.139 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.288084e-01 | 0.137 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.434552e-01 | 0.129 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.434552e-01 | 0.129 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.462557e-01 | 0.127 |
| R-HSA-72172 | mRNA Splicing | 7.466022e-01 | 0.127 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.602972e-01 | 0.119 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.841971e-01 | 0.106 |
| R-HSA-15869 | Metabolism of nucleotides | 7.920562e-01 | 0.101 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 7.933382e-01 | 0.101 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.990312e-01 | 0.097 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.240581e-01 | 0.084 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.294249e-01 | 0.081 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 8.396772e-01 | 0.076 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.414642e-01 | 0.075 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.502512e-01 | 0.070 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.557248e-01 | 0.068 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.566176e-01 | 0.067 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.922787e-01 | 0.049 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.955808e-01 | 0.048 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.045170e-01 | 0.044 |
| R-HSA-556833 | Metabolism of lipids | 9.061854e-01 | 0.043 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.206389e-01 | 0.036 |
| R-HSA-8978868 | Fatty acid metabolism | 9.286368e-01 | 0.032 |
| R-HSA-388396 | GPCR downstream signalling | 9.573691e-01 | 0.019 |
| R-HSA-211859 | Biological oxidations | 9.655381e-01 | 0.015 |
| R-HSA-372790 | Signaling by GPCR | 9.726681e-01 | 0.012 |
| R-HSA-1430728 | Metabolism | 9.907680e-01 | 0.004 |
| R-HSA-9709957 | Sensory Perception | 9.996549e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
NLK |
0.750 | 0.314 | 1 | 0.830 |
CLK3 |
0.744 | 0.187 | 1 | 0.767 |
CDK5 |
0.743 | 0.290 | 1 | 0.792 |
HIPK4 |
0.742 | 0.211 | 1 | 0.855 |
CDK16 |
0.741 | 0.317 | 1 | 0.725 |
CDK18 |
0.741 | 0.279 | 1 | 0.749 |
CDKL5 |
0.741 | 0.132 | -3 | 0.654 |
SRPK1 |
0.741 | 0.139 | -3 | 0.608 |
COT |
0.740 | 0.020 | 2 | 0.748 |
CDK10 |
0.740 | 0.302 | 1 | 0.778 |
CDK7 |
0.739 | 0.252 | 1 | 0.788 |
PKCD |
0.738 | 0.139 | 2 | 0.750 |
CDK8 |
0.738 | 0.248 | 1 | 0.771 |
WNK1 |
0.736 | 0.126 | -2 | 0.805 |
CDK19 |
0.736 | 0.252 | 1 | 0.754 |
CDKL1 |
0.736 | 0.101 | -3 | 0.662 |
MST4 |
0.736 | 0.118 | 2 | 0.795 |
CDK14 |
0.736 | 0.300 | 1 | 0.779 |
HIPK2 |
0.736 | 0.262 | 1 | 0.803 |
PKN2 |
0.736 | 0.118 | -3 | 0.691 |
P38A |
0.735 | 0.287 | 1 | 0.790 |
ERK5 |
0.735 | 0.138 | 1 | 0.739 |
PKCA |
0.734 | 0.163 | 2 | 0.748 |
CDK3 |
0.734 | 0.281 | 1 | 0.722 |
DYRK2 |
0.734 | 0.243 | 1 | 0.843 |
CDK17 |
0.734 | 0.269 | 1 | 0.708 |
PKN3 |
0.734 | 0.070 | -3 | 0.671 |
NUAK2 |
0.733 | 0.067 | -3 | 0.678 |
PKCB |
0.733 | 0.134 | 2 | 0.761 |
HIPK1 |
0.732 | 0.252 | 1 | 0.847 |
CLK1 |
0.732 | 0.180 | -3 | 0.596 |
ICK |
0.732 | 0.158 | -3 | 0.691 |
PKCG |
0.732 | 0.133 | 2 | 0.752 |
IRE2 |
0.732 | 0.114 | 2 | 0.687 |
CDK1 |
0.731 | 0.259 | 1 | 0.747 |
CDK13 |
0.731 | 0.227 | 1 | 0.781 |
PKCH |
0.731 | 0.149 | 2 | 0.731 |
ERK1 |
0.731 | 0.270 | 1 | 0.756 |
IRE1 |
0.731 | 0.113 | 1 | 0.710 |
NEK6 |
0.731 | 0.075 | -2 | 0.697 |
HIPK3 |
0.730 | 0.247 | 1 | 0.845 |
ULK2 |
0.730 | 0.011 | 2 | 0.698 |
AMPKA1 |
0.730 | 0.087 | -3 | 0.688 |
AURC |
0.730 | 0.150 | -2 | 0.728 |
PKCZ |
0.730 | 0.132 | 2 | 0.770 |
MTOR |
0.730 | -0.002 | 1 | 0.711 |
P38G |
0.730 | 0.271 | 1 | 0.703 |
PIM3 |
0.730 | 0.017 | -3 | 0.669 |
PAK6 |
0.729 | 0.217 | -2 | 0.747 |
GCN2 |
0.729 | -0.028 | 2 | 0.710 |
KIS |
0.729 | 0.171 | 1 | 0.810 |
MLK1 |
0.728 | 0.077 | 2 | 0.781 |
CDK6 |
0.728 | 0.292 | 1 | 0.777 |
P38B |
0.728 | 0.275 | 1 | 0.746 |
MLK3 |
0.728 | 0.125 | 2 | 0.759 |
RIPK3 |
0.728 | 0.036 | 3 | 0.654 |
PRPK |
0.727 | -0.070 | -1 | 0.664 |
NDR1 |
0.727 | 0.034 | -3 | 0.668 |
CDK12 |
0.727 | 0.231 | 1 | 0.767 |
TSSK1 |
0.727 | 0.076 | -3 | 0.703 |
CDC7 |
0.727 | -0.029 | 1 | 0.646 |
JNK2 |
0.727 | 0.261 | 1 | 0.762 |
CDK9 |
0.727 | 0.227 | 1 | 0.786 |
MNK1 |
0.727 | 0.118 | -2 | 0.812 |
RAF1 |
0.727 | -0.039 | 1 | 0.679 |
ATR |
0.726 | 0.032 | 1 | 0.718 |
AMPKA2 |
0.726 | 0.077 | -3 | 0.655 |
MNK2 |
0.726 | 0.098 | -2 | 0.815 |
PIM1 |
0.726 | 0.050 | -3 | 0.612 |
CAMK1B |
0.726 | 0.020 | -3 | 0.718 |
RSK2 |
0.726 | 0.055 | -3 | 0.619 |
MOS |
0.726 | 0.005 | 1 | 0.713 |
NDR2 |
0.725 | -0.005 | -3 | 0.659 |
RSK3 |
0.725 | 0.038 | -3 | 0.622 |
ERK7 |
0.725 | 0.221 | 2 | 0.656 |
TSSK2 |
0.725 | 0.065 | -5 | 0.713 |
NIK |
0.725 | 0.066 | -3 | 0.739 |
CLK4 |
0.725 | 0.161 | -3 | 0.608 |
CAMLCK |
0.725 | 0.094 | -2 | 0.811 |
NEK7 |
0.724 | 0.027 | -3 | 0.772 |
DYRK3 |
0.724 | 0.226 | 1 | 0.862 |
SRPK2 |
0.724 | 0.077 | -3 | 0.534 |
MARK4 |
0.724 | 0.053 | 4 | 0.729 |
DYRK1A |
0.724 | 0.194 | 1 | 0.826 |
PHKG1 |
0.723 | 0.062 | -3 | 0.664 |
PRKD1 |
0.723 | 0.013 | -3 | 0.673 |
DSTYK |
0.723 | -0.011 | 2 | 0.802 |
NEK9 |
0.723 | 0.075 | 2 | 0.784 |
NEK2 |
0.723 | 0.132 | 2 | 0.787 |
PKCE |
0.722 | 0.173 | 2 | 0.755 |
PKCT |
0.722 | 0.124 | 2 | 0.728 |
CDK2 |
0.722 | 0.208 | 1 | 0.768 |
PRKD2 |
0.722 | 0.017 | -3 | 0.604 |
PKG2 |
0.721 | 0.123 | -2 | 0.732 |
AURB |
0.721 | 0.130 | -2 | 0.728 |
ERK2 |
0.721 | 0.234 | 1 | 0.776 |
WNK3 |
0.721 | -0.040 | 1 | 0.687 |
NUAK1 |
0.721 | 0.025 | -3 | 0.632 |
JNK3 |
0.721 | 0.237 | 1 | 0.779 |
TBK1 |
0.721 | -0.081 | 1 | 0.613 |
PKACG |
0.721 | 0.063 | -2 | 0.759 |
PKCI |
0.721 | 0.154 | 2 | 0.758 |
MELK |
0.720 | 0.037 | -3 | 0.653 |
MLK2 |
0.720 | 0.052 | 2 | 0.763 |
CHAK2 |
0.720 | 0.011 | -1 | 0.641 |
PAK3 |
0.720 | 0.073 | -2 | 0.802 |
DAPK2 |
0.720 | 0.057 | -3 | 0.728 |
P90RSK |
0.720 | 0.013 | -3 | 0.625 |
SKMLCK |
0.720 | 0.038 | -2 | 0.810 |
DYRK1B |
0.720 | 0.218 | 1 | 0.791 |
CDK4 |
0.720 | 0.269 | 1 | 0.761 |
P38D |
0.720 | 0.257 | 1 | 0.748 |
PHKG2 |
0.720 | 0.097 | -3 | 0.645 |
CLK2 |
0.719 | 0.152 | -3 | 0.592 |
TGFBR2 |
0.719 | -0.031 | -2 | 0.616 |
BMPR2 |
0.719 | -0.113 | -2 | 0.730 |
PAK1 |
0.719 | 0.079 | -2 | 0.812 |
HUNK |
0.719 | -0.033 | 2 | 0.713 |
NIM1 |
0.718 | 0.004 | 3 | 0.635 |
CHAK1 |
0.718 | 0.059 | 2 | 0.737 |
PKR |
0.718 | 0.150 | 1 | 0.736 |
PDHK4 |
0.717 | -0.210 | 1 | 0.717 |
DYRK4 |
0.717 | 0.215 | 1 | 0.788 |
IRAK4 |
0.716 | 0.106 | 1 | 0.710 |
P70S6KB |
0.716 | 0.016 | -3 | 0.645 |
AKT2 |
0.716 | 0.082 | -3 | 0.540 |
SRPK3 |
0.716 | 0.061 | -3 | 0.585 |
PDHK1 |
0.716 | -0.149 | 1 | 0.711 |
ANKRD3 |
0.716 | 0.015 | 1 | 0.728 |
MAPKAPK3 |
0.716 | -0.020 | -3 | 0.627 |
MAK |
0.715 | 0.225 | -2 | 0.785 |
SIK |
0.715 | 0.034 | -3 | 0.601 |
QIK |
0.715 | 0.015 | -3 | 0.698 |
SGK3 |
0.715 | 0.074 | -3 | 0.612 |
IKKE |
0.715 | -0.095 | 1 | 0.602 |
PRKD3 |
0.715 | 0.016 | -3 | 0.601 |
QSK |
0.715 | 0.052 | 4 | 0.730 |
MOK |
0.715 | 0.228 | 1 | 0.843 |
PIM2 |
0.715 | 0.065 | -3 | 0.597 |
MLK4 |
0.714 | 0.050 | 2 | 0.725 |
SSTK |
0.713 | 0.114 | 4 | 0.711 |
PKACB |
0.712 | 0.092 | -2 | 0.736 |
MASTL |
0.712 | -0.113 | -2 | 0.697 |
ULK1 |
0.712 | -0.107 | -3 | 0.730 |
PKN1 |
0.712 | 0.084 | -3 | 0.590 |
MPSK1 |
0.712 | 0.176 | 1 | 0.727 |
PINK1 |
0.711 | 0.105 | 1 | 0.796 |
CAMK2G |
0.711 | -0.139 | 2 | 0.636 |
LATS2 |
0.711 | -0.054 | -5 | 0.618 |
AKT1 |
0.710 | 0.095 | -3 | 0.556 |
MARK3 |
0.710 | 0.066 | 4 | 0.726 |
CAMK4 |
0.710 | -0.032 | -3 | 0.660 |
CAMK1G |
0.710 | 0.035 | -3 | 0.617 |
MST3 |
0.710 | 0.142 | 2 | 0.824 |
IKKB |
0.709 | -0.169 | -2 | 0.592 |
RSK4 |
0.709 | 0.032 | -3 | 0.574 |
TTBK2 |
0.709 | -0.074 | 2 | 0.691 |
RIPK1 |
0.708 | -0.089 | 1 | 0.722 |
MYLK4 |
0.708 | 0.056 | -2 | 0.768 |
WNK4 |
0.708 | 0.039 | -2 | 0.790 |
BCKDK |
0.707 | -0.140 | -1 | 0.590 |
PAK4 |
0.707 | 0.158 | -2 | 0.721 |
PAK2 |
0.707 | 0.041 | -2 | 0.792 |
BRSK2 |
0.707 | -0.020 | -3 | 0.666 |
HRI |
0.706 | 0.020 | -2 | 0.675 |
AURA |
0.706 | 0.099 | -2 | 0.709 |
MSK2 |
0.706 | -0.007 | -3 | 0.597 |
VRK2 |
0.706 | 0.021 | 1 | 0.771 |
PRP4 |
0.706 | 0.108 | -3 | 0.655 |
PRKX |
0.705 | 0.077 | -3 | 0.505 |
PAK5 |
0.704 | 0.131 | -2 | 0.707 |
SNRK |
0.704 | -0.056 | 2 | 0.568 |
SMG1 |
0.704 | -0.007 | 1 | 0.690 |
SMMLCK |
0.703 | 0.066 | -3 | 0.682 |
MARK2 |
0.703 | 0.031 | 4 | 0.676 |
CAMK2D |
0.703 | -0.120 | -3 | 0.706 |
MEKK1 |
0.703 | 0.035 | 1 | 0.691 |
LATS1 |
0.703 | -0.023 | -3 | 0.678 |
ATM |
0.703 | -0.054 | 1 | 0.670 |
DNAPK |
0.702 | -0.022 | 1 | 0.651 |
GRK5 |
0.702 | -0.188 | -3 | 0.713 |
YSK4 |
0.702 | -0.049 | 1 | 0.612 |
BRSK1 |
0.702 | -0.034 | -3 | 0.637 |
PERK |
0.702 | 0.016 | -2 | 0.636 |
AKT3 |
0.702 | 0.084 | -3 | 0.482 |
NEK5 |
0.700 | 0.040 | 1 | 0.705 |
PKACA |
0.700 | 0.078 | -2 | 0.699 |
MRCKB |
0.700 | 0.107 | -3 | 0.587 |
DRAK1 |
0.699 | -0.050 | 1 | 0.578 |
MSK1 |
0.699 | 0.018 | -3 | 0.605 |
CHK1 |
0.699 | -0.067 | -3 | 0.666 |
MAPKAPK2 |
0.699 | -0.063 | -3 | 0.571 |
MEK1 |
0.699 | -0.111 | 2 | 0.711 |
DCAMKL1 |
0.698 | -0.027 | -3 | 0.614 |
DLK |
0.698 | -0.208 | 1 | 0.654 |
TAO2 |
0.697 | 0.083 | 2 | 0.784 |
MARK1 |
0.697 | -0.005 | 4 | 0.725 |
FAM20C |
0.697 | -0.058 | 2 | 0.466 |
PLK1 |
0.696 | -0.104 | -2 | 0.676 |
BUB1 |
0.696 | 0.102 | -5 | 0.607 |
MEK5 |
0.696 | -0.067 | 2 | 0.729 |
ZAK |
0.695 | -0.035 | 1 | 0.633 |
ROCK2 |
0.695 | 0.108 | -3 | 0.626 |
GRK1 |
0.695 | -0.085 | -2 | 0.606 |
MEKK2 |
0.695 | -0.021 | 2 | 0.732 |
ALK4 |
0.694 | -0.093 | -2 | 0.641 |
NEK4 |
0.693 | 0.053 | 1 | 0.674 |
JNK1 |
0.693 | 0.181 | 1 | 0.741 |
P70S6K |
0.693 | -0.023 | -3 | 0.573 |
NEK8 |
0.693 | 0.028 | 2 | 0.765 |
IRAK1 |
0.693 | -0.067 | -1 | 0.558 |
TNIK |
0.693 | 0.109 | 3 | 0.725 |
MEKK6 |
0.692 | 0.063 | 1 | 0.630 |
TAO3 |
0.692 | 0.003 | 1 | 0.649 |
DMPK1 |
0.692 | 0.133 | -3 | 0.598 |
LIMK2_TYR |
0.692 | 0.167 | -3 | 0.765 |
GRK6 |
0.692 | -0.184 | 1 | 0.642 |
IKKA |
0.692 | -0.166 | -2 | 0.570 |
NEK1 |
0.692 | 0.112 | 1 | 0.687 |
DCAMKL2 |
0.692 | -0.054 | -3 | 0.652 |
SGK1 |
0.692 | 0.046 | -3 | 0.470 |
HGK |
0.691 | 0.069 | 3 | 0.730 |
PLK4 |
0.691 | -0.109 | 2 | 0.517 |
LOK |
0.691 | 0.062 | -2 | 0.712 |
CAMK2A |
0.691 | -0.111 | 2 | 0.624 |
GSK3A |
0.691 | 0.008 | 4 | 0.308 |
MRCKA |
0.691 | 0.066 | -3 | 0.600 |
PLK3 |
0.690 | -0.105 | 2 | 0.615 |
YSK1 |
0.690 | 0.113 | 2 | 0.790 |
EEF2K |
0.690 | 0.059 | 3 | 0.717 |
DAPK3 |
0.689 | 0.052 | -3 | 0.637 |
TTBK1 |
0.689 | -0.080 | 2 | 0.594 |
PKG1 |
0.688 | 0.075 | -2 | 0.699 |
CAMK1D |
0.688 | -0.019 | -3 | 0.537 |
CAMK1A |
0.688 | 0.020 | -3 | 0.508 |
BRAF |
0.688 | -0.087 | -4 | 0.729 |
BMPR1B |
0.688 | -0.067 | 1 | 0.559 |
GAK |
0.688 | 0.055 | 1 | 0.715 |
CAMK2B |
0.687 | -0.136 | 2 | 0.591 |
ROCK1 |
0.687 | 0.107 | -3 | 0.599 |
GRK4 |
0.687 | -0.218 | -2 | 0.636 |
PKMYT1_TYR |
0.687 | 0.103 | 3 | 0.717 |
GSK3B |
0.687 | -0.036 | 4 | 0.300 |
PDK1 |
0.687 | -0.010 | 1 | 0.709 |
TGFBR1 |
0.686 | -0.099 | -2 | 0.603 |
LRRK2 |
0.686 | 0.042 | 2 | 0.774 |
KHS1 |
0.686 | 0.066 | 1 | 0.649 |
PDHK3_TYR |
0.686 | 0.037 | 4 | 0.685 |
TNNI3K_TYR |
0.686 | 0.139 | 1 | 0.709 |
NEK11 |
0.685 | -0.081 | 1 | 0.664 |
MAP3K15 |
0.685 | -0.003 | 1 | 0.630 |
MEKK3 |
0.685 | -0.142 | 1 | 0.651 |
CHK2 |
0.684 | -0.013 | -3 | 0.496 |
MINK |
0.684 | 0.034 | 1 | 0.642 |
MAPKAPK5 |
0.684 | -0.124 | -3 | 0.604 |
TESK1_TYR |
0.684 | 0.033 | 3 | 0.721 |
LKB1 |
0.684 | -0.026 | -3 | 0.737 |
HASPIN |
0.683 | 0.046 | -1 | 0.518 |
MYO3B |
0.683 | 0.149 | 2 | 0.796 |
ACVR2A |
0.682 | -0.122 | -2 | 0.595 |
TLK2 |
0.681 | -0.161 | 1 | 0.665 |
HPK1 |
0.681 | 0.013 | 1 | 0.637 |
LIMK1_TYR |
0.681 | 0.052 | 2 | 0.745 |
VRK1 |
0.681 | 0.025 | 2 | 0.725 |
KHS2 |
0.681 | 0.048 | 1 | 0.652 |
ROS1 |
0.681 | 0.046 | 3 | 0.692 |
ACVR2B |
0.681 | -0.122 | -2 | 0.602 |
JAK1 |
0.681 | 0.113 | 1 | 0.630 |
NEK3 |
0.680 | 0.017 | 1 | 0.658 |
GCK |
0.680 | -0.034 | 1 | 0.636 |
CAMKK1 |
0.679 | -0.098 | -2 | 0.599 |
STK33 |
0.679 | -0.055 | 2 | 0.553 |
RET |
0.679 | 0.013 | 1 | 0.679 |
TYK2 |
0.679 | 0.024 | 1 | 0.679 |
PINK1_TYR |
0.679 | -0.008 | 1 | 0.702 |
GRK7 |
0.679 | -0.119 | 1 | 0.596 |
CK1E |
0.679 | -0.080 | -3 | 0.409 |
MST1R |
0.679 | 0.036 | 3 | 0.716 |
PBK |
0.678 | 0.034 | 1 | 0.658 |
MAP2K7_TYR |
0.678 | -0.094 | 2 | 0.720 |
ALK2 |
0.678 | -0.135 | -2 | 0.598 |
SBK |
0.677 | 0.002 | -3 | 0.435 |
SLK |
0.677 | -0.029 | -2 | 0.636 |
DAPK1 |
0.677 | 0.016 | -3 | 0.625 |
EPHA6 |
0.677 | 0.054 | -1 | 0.660 |
MST2 |
0.676 | -0.083 | 1 | 0.643 |
CSF1R |
0.676 | 0.022 | 3 | 0.698 |
TNK1 |
0.676 | 0.041 | 3 | 0.669 |
TAK1 |
0.676 | -0.025 | 1 | 0.660 |
DDR1 |
0.675 | -0.030 | 4 | 0.663 |
RIPK2 |
0.675 | -0.101 | 1 | 0.617 |
JAK2 |
0.675 | 0.001 | 1 | 0.678 |
TYRO3 |
0.674 | -0.034 | 3 | 0.710 |
TLK1 |
0.674 | -0.170 | -2 | 0.629 |
MYO3A |
0.674 | 0.091 | 1 | 0.687 |
CAMKK2 |
0.674 | -0.120 | -2 | 0.612 |
WEE1_TYR |
0.673 | 0.080 | -1 | 0.563 |
GRK2 |
0.673 | -0.141 | -2 | 0.538 |
MAP2K4_TYR |
0.673 | -0.142 | -1 | 0.671 |
PASK |
0.672 | -0.116 | -3 | 0.690 |
TAO1 |
0.672 | 0.045 | 1 | 0.609 |
PDHK4_TYR |
0.672 | -0.097 | 2 | 0.708 |
TNK2 |
0.672 | 0.026 | 3 | 0.703 |
TTK |
0.672 | 0.013 | -2 | 0.664 |
CRIK |
0.672 | 0.020 | -3 | 0.548 |
CK1G1 |
0.671 | -0.102 | -3 | 0.404 |
MEK2 |
0.671 | -0.095 | 2 | 0.699 |
BMPR1A |
0.671 | -0.093 | 1 | 0.540 |
BLK |
0.671 | 0.078 | -1 | 0.660 |
BMPR2_TYR |
0.671 | -0.045 | -1 | 0.676 |
LCK |
0.671 | 0.066 | -1 | 0.664 |
MST1 |
0.670 | -0.069 | 1 | 0.631 |
MAP2K6_TYR |
0.669 | -0.156 | -1 | 0.679 |
CK1A2 |
0.669 | -0.074 | -3 | 0.362 |
DDR2 |
0.668 | 0.043 | 3 | 0.680 |
BIKE |
0.668 | 0.046 | 1 | 0.651 |
ABL2 |
0.668 | -0.007 | -1 | 0.597 |
JAK3 |
0.668 | -0.038 | 1 | 0.642 |
YES1 |
0.668 | -0.021 | -1 | 0.660 |
CK1D |
0.667 | -0.086 | -3 | 0.365 |
EPHB4 |
0.667 | -0.049 | -1 | 0.638 |
HCK |
0.666 | 0.003 | -1 | 0.656 |
KDR |
0.666 | -0.014 | 3 | 0.663 |
PDGFRB |
0.665 | -0.057 | 3 | 0.719 |
TEK |
0.665 | -0.041 | 3 | 0.660 |
PDHK1_TYR |
0.665 | -0.172 | -1 | 0.688 |
PDGFRA |
0.665 | -0.043 | 3 | 0.726 |
FLT3 |
0.664 | -0.038 | 3 | 0.698 |
FGR |
0.663 | -0.055 | 1 | 0.650 |
ALK |
0.663 | -0.021 | 3 | 0.673 |
NEK10_TYR |
0.662 | -0.055 | 1 | 0.571 |
ABL1 |
0.662 | -0.031 | -1 | 0.587 |
ASK1 |
0.662 | -0.031 | 1 | 0.622 |
OSR1 |
0.661 | -0.040 | 2 | 0.727 |
TXK |
0.661 | -0.023 | 1 | 0.595 |
AAK1 |
0.660 | 0.075 | 1 | 0.582 |
PLK2 |
0.660 | -0.097 | -3 | 0.710 |
INSRR |
0.659 | -0.105 | 3 | 0.661 |
KIT |
0.659 | -0.077 | 3 | 0.700 |
AXL |
0.659 | -0.086 | 3 | 0.684 |
FGFR1 |
0.659 | -0.080 | 3 | 0.689 |
FGFR2 |
0.659 | -0.095 | 3 | 0.678 |
ITK |
0.658 | -0.062 | -1 | 0.615 |
EPHA1 |
0.657 | -0.020 | 3 | 0.676 |
TEC |
0.656 | -0.045 | -1 | 0.553 |
GRK3 |
0.656 | -0.143 | -2 | 0.486 |
FER |
0.656 | -0.140 | 1 | 0.654 |
EPHB1 |
0.656 | -0.090 | 1 | 0.624 |
BTK |
0.656 | -0.080 | -1 | 0.592 |
LTK |
0.656 | -0.061 | 3 | 0.676 |
EPHB3 |
0.655 | -0.094 | -1 | 0.629 |
FRK |
0.654 | -0.031 | -1 | 0.662 |
EPHA4 |
0.654 | -0.083 | 2 | 0.615 |
BMX |
0.654 | -0.054 | -1 | 0.558 |
MET |
0.653 | -0.074 | 3 | 0.689 |
MERTK |
0.652 | -0.100 | 3 | 0.654 |
FYN |
0.652 | -0.014 | -1 | 0.660 |
SRMS |
0.651 | -0.123 | 1 | 0.626 |
YANK3 |
0.651 | -0.072 | 2 | 0.358 |
LYN |
0.651 | -0.040 | 3 | 0.644 |
PTK6 |
0.651 | -0.129 | -1 | 0.546 |
EPHA7 |
0.650 | -0.059 | 2 | 0.631 |
CK2A2 |
0.650 | -0.120 | 1 | 0.487 |
EPHB2 |
0.650 | -0.102 | -1 | 0.620 |
FLT4 |
0.649 | -0.115 | 3 | 0.652 |
FLT1 |
0.647 | -0.103 | -1 | 0.624 |
INSR |
0.646 | -0.134 | 3 | 0.645 |
NTRK2 |
0.645 | -0.156 | 3 | 0.684 |
FGFR3 |
0.644 | -0.141 | 3 | 0.661 |
MATK |
0.644 | -0.093 | -1 | 0.522 |
MUSK |
0.642 | -0.061 | 1 | 0.497 |
EPHA3 |
0.641 | -0.141 | 2 | 0.597 |
ERBB2 |
0.641 | -0.155 | 1 | 0.590 |
NTRK1 |
0.640 | -0.209 | -1 | 0.609 |
CK2A1 |
0.639 | -0.129 | 1 | 0.462 |
PTK2B |
0.639 | -0.107 | -1 | 0.584 |
EPHA8 |
0.639 | -0.077 | -1 | 0.620 |
SRC |
0.638 | -0.086 | -1 | 0.634 |
NTRK3 |
0.638 | -0.148 | -1 | 0.583 |
CSK |
0.636 | -0.126 | 2 | 0.632 |
STLK3 |
0.635 | -0.159 | 1 | 0.605 |
EPHA5 |
0.633 | -0.133 | 2 | 0.590 |
ALPHAK3 |
0.633 | -0.180 | -1 | 0.566 |
EGFR |
0.629 | -0.127 | 1 | 0.508 |
PTK2 |
0.628 | -0.056 | -1 | 0.623 |
FGFR4 |
0.627 | -0.143 | -1 | 0.560 |
IGF1R |
0.626 | -0.162 | 3 | 0.589 |
EPHA2 |
0.625 | -0.102 | -1 | 0.587 |
CK1A |
0.624 | -0.129 | -3 | 0.282 |
SYK |
0.621 | -0.101 | -1 | 0.617 |
ERBB4 |
0.617 | -0.109 | 1 | 0.510 |
YANK2 |
0.616 | -0.103 | 2 | 0.367 |
FES |
0.613 | -0.143 | -1 | 0.523 |
CK1G3 |
0.606 | -0.133 | -3 | 0.242 |
ZAP70 |
0.604 | -0.106 | -1 | 0.540 |
CK1G2 |
0.586 | -0.137 | -3 | 0.328 |