Motif 698 (n=59)

Position-wise Probabilities

Download

uniprot	genes	site	source	protein	function
A8K0Z3	WASHC1	S217	ochoa	WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1)	Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250\|UniProtKB:C4AMC7, ECO:0000250\|UniProtKB:Q8VDD8, ECO:0000269\|PubMed:19922874, ECO:0000269\|PubMed:19922875, ECO:0000269\|PubMed:20498093, ECO:0000269\|PubMed:22114305, ECO:0000269\|PubMed:23452853, ECO:0000305\|PubMed:20498093}.
A8MWX3	WASH4P	S230	ochoa	Putative WAS protein family homolog 4 (Protein FAM39CP)	May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250\|UniProtKB:A8K0Z3, ECO:0000250\|UniProtKB:C4AMC7}.
C4AMC7	WASH3P	S215	ochoa	Putative WAS protein family homolog 3 (Protein FAM39DP)	Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250\|UniProtKB:A8K0Z3, ECO:0000250\|UniProtKB:Q8VDD8, ECO:0000269\|PubMed:18159949, ECO:0000269\|PubMed:20175130}.
P0C0S8	H2AC11	S20	ochoa	Histone H2A type 1 (H2A.1) (Histone H2A/ptl)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P0DPH7	TUBA3C	Y262	ochoa	Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain]	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8	TUBA3D	Y262	ochoa	Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain]	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P11055	MYH3	S1336	ochoa	Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE)	Muscle contraction.
P12882	MYH1	S668	ochoa	Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1)	Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250\|UniProtKB:Q5SX40}.
P12882	MYH1	S1339	ochoa	Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1)	Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250\|UniProtKB:Q5SX40}.
P12883	MYH7	S664	ochoa	Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305\|PubMed:26150528, ECO:0000305\|PubMed:26246073}.
P12883	MYH7	S1335	ochoa	Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305\|PubMed:26150528, ECO:0000305\|PubMed:26246073}.
P13533	MYH6	S1337	ochoa	Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)	Muscle contraction.
P13535	MYH8	S667	ochoa	Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)	Muscle contraction.
P13535	MYH8	S1338	ochoa	Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)	Muscle contraction.
P20671	H2AC7	S20	ochoa	Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P41229	KDM5C	S897	ochoa	Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C)	Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250\|UniProtKB:P41230, ECO:0000269\|PubMed:17320160, ECO:0000269\|PubMed:17320161, ECO:0000269\|PubMed:17468742, ECO:0000269\|PubMed:26645689, ECO:0000269\|PubMed:28262558}.
P46940	IQGAP1	S330	ochoa	Ras GTPase-activating-like protein IQGAP1 (p195)	Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250\|UniProtKB:Q9JKF1, ECO:0000269\|PubMed:15695813, ECO:0000269\|PubMed:20883816}.
P68363	TUBA1B	Y262	ochoa	Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]	Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269\|PubMed:34996871, ECO:0000269\|PubMed:38305685, ECO:0000269\|PubMed:38609661}.
P68366	TUBA4A	Y262	ochoa	Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain)	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q6PEY2	TUBA3E	Y262	ochoa	Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain]	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q6VEQ5	WASH2P	S217	ochoa	WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B)	Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250\|UniProtKB:A8K0Z3, ECO:0000250\|UniProtKB:C4AMC7, ECO:0000250\|UniProtKB:Q8VDD8}.
Q71U36	TUBA1A	Y262	ochoa	Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q96KK5	H2AC12	S20	ochoa	Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q99878	H2AC14	S20	ochoa	Histone H2A type 1-J (Histone H2A/e)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q9BQE3	TUBA1C	Y262	ochoa	Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9BY66	KDM5D	S884	ochoa	Lysine-specific demethylase 5D (EC 1.14.11.67) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY) ([histone H3]-trimethyl-L-lysine(4) demethylase 5D)	Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. {ECO:0000269\|PubMed:17320160, ECO:0000269\|PubMed:17320162, ECO:0000269\|PubMed:17351630, ECO:0000269\|PubMed:26747897, ECO:0000269\|PubMed:27185910, ECO:0000269\|PubMed:27427228, ECO:0000269\|PubMed:27477906}.
Q9NQA3	WASH6P	S199	ochoa	WAS protein family homolog 6 (Protein FAM39A)	May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250\|UniProtKB:A8K0Z3, ECO:0000250\|UniProtKB:C4AMC7}.
Q9NY65	TUBA8	Y262	ochoa	Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain]	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9UKX2	MYH2	S670	ochoa	Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250\|UniProtKB:P12883}.
Q9UKX2	MYH2	S1341	ochoa	Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250\|UniProtKB:P12883}.
Q9UKX3	MYH13	S668	ochoa	Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin)	Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269\|PubMed:23908353}.
Q9Y623	MYH4	S668	ochoa	Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal)	Muscle contraction.
O95678	KRT75	S162	Sugiyama	Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (hK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18)	Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
P02538	KRT6A	S176	Sugiyama	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5)	Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. {ECO:0000250\|UniProtKB:P50446}.
P04259	KRT6B	S176	Sugiyama	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10)	None
P05787	KRT8	S104	Sugiyama	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)	Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269\|PubMed:16000376}.
P08729	KRT7	S104	Sugiyama	Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)	Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). {ECO:0000269\|PubMed:10492017, ECO:0000269\|PubMed:12072504}.
P12035	KRT3	S211	Sugiyama	Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3)	None
P13647	KRT5	S181	Sugiyama	Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)	Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity). {ECO:0000250\|UniProtKB:Q922U2}.
P35908	KRT2	S191	Sugiyama	Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)	Probably contributes to terminal cornification (PubMed:1380918). Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329). Required for maintenance of corneocytes and keratin filaments in suprabasal keratinocytes in the epidermis of the ear, potentially via moderation of expression and localization of keratins and their partner proteins (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). {ECO:0000250\|UniProtKB:Q3TTY5, ECO:0000269\|PubMed:12598329, ECO:0000269\|PubMed:1380918}.
P48668	KRT6C	S176	Sugiyama	Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12)	None
Q01546	KRT76	S196	Sugiyama	Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)	Probably contributes to terminal cornification. {ECO:0000269\|PubMed:1282112}.
Q14CN4	KRT72	S138	Sugiyama	Keratin, type II cytoskeletal 72 (Cytokeratin-72) (CK-72) (Keratin-72) (K72) (Type II inner root sheath-specific keratin-K6irs2) (Type-II keratin Kb35)	Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}.
Q3SY84	KRT71	S143	Sugiyama	Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34)	Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. {ECO:0000269\|PubMed:22592156}.
Q5XKE5	KRT79	S155	Sugiyama	Keratin, type II cytoskeletal 79 (Cytokeratin-79) (CK-79) (Keratin-6-like) (Keratin-6L) (Keratin-79) (K79) (Type-II keratin Kb38)	None
Q7RTS7	KRT74	S153	Sugiyama	Keratin, type II cytoskeletal 74 (Cytokeratin-74) (CK-74) (Keratin-5c) (K5C) (Keratin-74) (K74) (Type II inner root sheath-specific keratin-K6irs4) (Type-II keratin Kb37)	Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}.
Q7Z794	KRT77	S177	Sugiyama	Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)	None
Q86Y46	KRT73	S145	Sugiyama	Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36)	Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}.
Q9NSB2	KRT84	S178	Sugiyama	Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24)	None
P05783	KRT18	S93	Sugiyama	Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269\|PubMed:15529338, ECO:0000269\|PubMed:16424149, ECO:0000269\|PubMed:17213200, ECO:0000269\|PubMed:7523419, ECO:0000269\|PubMed:8522591, ECO:0000269\|PubMed:9298992, ECO:0000269\|PubMed:9524113}.
P04908	H2AC4	S20	Sugiyama	Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P16104	H2AX	S20	Sugiyama	Histone H2AX (H2a/x) (Histone H2A.X)	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. {ECO:0000269\|PubMed:10959836, ECO:0000269\|PubMed:12419185, ECO:0000269\|PubMed:12607005, ECO:0000269\|PubMed:15201865, ECO:0000269\|PubMed:17709392, ECO:0000269\|PubMed:26438602}.
Q16777	H2AC20	S20	Sugiyama	Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q6FI13	H2AC18	S20	Sugiyama	Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q7L7L0	H2AC25	S20	Sugiyama	Histone H2A type 3 (H2A-clustered histone 25)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q8IUE6	H2AC21	S20	Sugiyama	Histone H2A type 2-B (H2A-clustered histone 21)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q93077	H2AC6	S20	Sugiyama	Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q96QV6	H2AC1	S20	Sugiyama	Histone H2A type 1-A (H2A-clustered histone 1) (Histone H2A/r)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q9BTM1	H2AJ	S20	Sugiyama	Histone H2A.J (H2a/j)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Download

reactome_id	name	p	-log10_p
R-HSA-9609690	HCMV Early Events	1.110223e-16	15.955
R-HSA-6805567	Keratinization	1.110223e-16	15.955
R-HSA-5689901	Metalloprotease DUBs	1.110223e-16	15.955
R-HSA-6809371	Formation of the cornified envelope	1.110223e-16	15.955
R-HSA-9609646	HCMV Infection	1.110223e-16	15.955
R-HSA-3214858	RMTs methylate histone arginines	1.110223e-16	15.955
R-HSA-1266738	Developmental Biology	1.110223e-16	15.955
R-HSA-3214815	HDACs deacetylate histones	9.992007e-16	15.000
R-HSA-5689603	UCH proteinases	2.109424e-14	13.676
R-HSA-3247509	Chromatin modifying enzymes	2.531308e-14	13.597
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	2.919887e-14	13.535
R-HSA-190872	Transport of connexons to the plasma membrane	4.152234e-14	13.382
R-HSA-4839726	Chromatin organization	5.762057e-14	13.239
R-HSA-389977	Post-chaperonin tubulin folding pathway	8.038015e-14	13.095
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	3.406164e-13	12.468
R-HSA-3214847	HATs acetylate histones	3.808065e-13	12.419
R-HSA-171306	Packaging Of Telomere Ends	7.239764e-13	12.140
R-HSA-73728	RNA Polymerase I Promoter Opening	7.239764e-13	12.140
R-HSA-9619483	Activation of AMPK downstream of NMDARs	9.166001e-13	12.038
R-HSA-5334118	DNA methylation	1.152523e-12	11.938
R-HSA-68886	M Phase	1.243672e-12	11.905
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	1.787459e-12	11.748
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected ...	2.206124e-12	11.656
R-HSA-68616	Assembly of the ORC complex at the origin of replication	2.707945e-12	11.567
R-HSA-9668328	Sealing of the nuclear envelope (NE) by ESCRT-III	2.707945e-12	11.567
R-HSA-9843970	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	4.016898e-12	11.396
R-HSA-190861	Gap junction assembly	4.016898e-12	11.396
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected ...	4.016898e-12	11.396
R-HSA-212300	PRC2 methylates histones and DNA	5.846212e-12	11.233
R-HSA-427359	SIRT1 negatively regulates rRNA expression	7.006506e-12	11.154
R-HSA-110331	Cleavage of the damaged purine	7.006506e-12	11.154
R-HSA-5689880	Ub-specific processing proteases	6.797118e-12	11.168
R-HSA-73927	Depurination	8.362422e-12	11.078
R-HSA-9670095	Inhibition of DNA recombination at telomere	1.177380e-11	10.929
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	1.177380e-11	10.929
R-HSA-9646399	Aggrephagy	1.177380e-11	10.929
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene...	1.389366e-11	10.857
R-HSA-9821002	Chromatin modifications during the maternal to zygotic transition (MZT)	1.389366e-11	10.857
R-HSA-9609736	Assembly and cell surface presentation of NMDA receptors	1.633826e-11	10.787
R-HSA-110329	Cleavage of the damaged pyrimidine	1.914924e-11	10.718
R-HSA-73928	Depyrimidination	1.914924e-11	10.718
R-HSA-9710421	Defective pyroptosis	2.237199e-11	10.650
R-HSA-190828	Gap junction trafficking	2.605682e-11	10.584
R-HSA-774815	Nucleosome assembly	3.025902e-11	10.519
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	3.025902e-11	10.519
R-HSA-2299718	Condensation of Prophase Chromosomes	3.503886e-11	10.455
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin	4.046252e-11	10.393
R-HSA-437239	Recycling pathway of L1	4.046252e-11	10.393
R-HSA-9610379	HCMV Late Events	5.244094e-11	10.280
R-HSA-157858	Gap junction trafficking and regulation	5.353706e-11	10.271
R-HSA-912446	Meiotic recombination	7.014156e-11	10.154
R-HSA-73772	RNA Polymerase I Promoter Escape	8.000578e-11	10.097
R-HSA-1221632	Meiotic synapsis	9.105461e-11	10.041
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	9.105461e-11	10.041
R-HSA-73929	Base-Excision Repair, AP Site Formation	1.034067e-10	9.985
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	1.171903e-10	9.931
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	1.685676e-10	9.773
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	2.128128e-10	9.672
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	2.668173e-10	9.574
R-HSA-983189	Kinesins	2.128128e-10	9.672
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	2.128128e-10	9.672
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	2.668173e-10	9.574
R-HSA-9616222	Transcriptional regulation of granulopoiesis	2.668173e-10	9.574
R-HSA-69278	Cell Cycle, Mitotic	3.143683e-10	9.503
R-HSA-5688426	Deubiquitination	4.023248e-10	9.395
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	4.114246e-10	9.386
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	5.063472e-10	9.296
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig...	5.063472e-10	9.296
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins	6.197258e-10	9.208
R-HSA-9764560	Regulation of CDH1 Gene Transcription	6.197258e-10	9.208
R-HSA-427413	NoRC negatively regulates rRNA expression	6.842440e-10	9.165
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	6.842440e-10	9.165
R-HSA-5620920	Cargo trafficking to the periciliary membrane	6.842440e-10	9.165
R-HSA-5578749	Transcriptional regulation by small RNAs	7.545111e-10	9.122
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	8.309547e-10	9.080
R-HSA-73854	RNA Polymerase I Promoter Clearance	1.102011e-09	8.958
R-HSA-73864	RNA Polymerase I Transcription	1.322641e-09	8.879
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	1.580587e-09	8.801
R-HSA-2995410	Nuclear Envelope (NE) Reassembly	1.580587e-09	8.801
R-HSA-9833482	PKR-mediated signaling	1.580587e-09	8.801
R-HSA-1500620	Meiosis	2.424246e-09	8.615
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	2.229793e-09	8.652
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	1.881047e-09	8.726
R-HSA-390466	Chaperonin-mediated protein folding	3.098393e-09	8.509
R-HSA-438064	Post NMDA receptor activation events	3.098393e-09	8.509
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	3.356539e-09	8.474
R-HSA-9663891	Selective autophagy	3.356539e-09	8.474
R-HSA-9645723	Diseases of programmed cell death	3.356539e-09	8.474
R-HSA-73884	Base Excision Repair	3.929176e-09	8.406
R-HSA-1912408	Pre-NOTCH Transcription and Translation	4.245912e-09	8.372
R-HSA-391251	Protein folding	4.946231e-09	8.306
R-HSA-68867	Assembly of the pre-replicative complex	5.332389e-09	8.273
R-HSA-1640170	Cell Cycle	6.903136e-09	8.161
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	7.149866e-09	8.146
R-HSA-6807878	COPI-mediated anterograde transport	7.149866e-09	8.146
R-HSA-157579	Telomere Maintenance	7.680131e-09	8.115
R-HSA-9842860	Regulation of endogenous retroelements	1.087327e-08	7.964
R-HSA-2559580	Oxidative Stress Induced Senescence	1.087327e-08	7.964
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	1.087327e-08	7.964
R-HSA-5619507	Activation of HOX genes during differentiation	1.329379e-08	7.876
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	1.329379e-08	7.876
R-HSA-211000	Gene Silencing by RNA	1.616637e-08	7.791
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	1.836627e-08	7.736
R-HSA-69002	DNA Replication Pre-Initiation	1.836627e-08	7.736
R-HSA-9824446	Viral Infection Pathways	1.882427e-08	7.725
R-HSA-1912422	Pre-NOTCH Expression and Processing	2.355159e-08	7.628
R-HSA-373760	L1CAM interactions	3.177160e-08	7.498
R-HSA-9927418	Developmental Lineage of Mammary Gland Luminal Epithelial Cells	3.885953e-08	7.411
R-HSA-68875	Mitotic Prophase	4.002506e-08	7.398
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	4.235591e-08	7.373
R-HSA-73886	Chromosome Maintenance	4.235591e-08	7.373
R-HSA-977225	Amyloid fiber formation	4.708099e-08	7.327
R-HSA-9816359	Maternal to zygotic transition (MZT)	4.737061e-08	7.324
R-HSA-2132295	MHC class II antigen presentation	4.737061e-08	7.324
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	5.584950e-08	7.253
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	5.584950e-08	7.253
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	5.584950e-08	7.253
R-HSA-5620924	Intraflagellar transport	7.539083e-08	7.123
R-HSA-1474165	Reproduction	7.679245e-08	7.115
R-HSA-8856688	Golgi-to-ER retrograde transport	8.513134e-08	7.070
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	9.526569e-08	7.021
R-HSA-9018519	Estrogen-dependent gene expression	1.094654e-07	6.961
R-HSA-199977	ER to Golgi Anterograde Transport	1.934703e-07	6.713
R-HSA-1632852	Macroautophagy	1.395569e-07	6.855
R-HSA-69306	DNA Replication	2.530517e-07	6.597
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	2.643733e-07	6.578
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	2.643733e-07	6.578
R-HSA-9612973	Autophagy	2.883254e-07	6.540
R-HSA-2467813	Separation of Sister Chromatids	4.036967e-07	6.394
R-HSA-1500931	Cell-Cell communication	4.544999e-07	6.342
R-HSA-9909648	Regulation of PD-L1(CD274) expression	5.787541e-07	6.238
R-HSA-9924644	Developmental Lineages of the Mammary Gland	5.981155e-07	6.223
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	6.017084e-07	6.221
R-HSA-9764265	Regulation of CDH1 Expression and Function	6.017084e-07	6.221
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	6.499625e-07	6.187
R-HSA-2559583	Cellular Senescence	7.853157e-07	6.105
R-HSA-2262752	Cellular responses to stress	8.703280e-07	6.060
R-HSA-201681	TCF dependent signaling in response to WNT	8.775613e-07	6.057
R-HSA-69275	G2/M Transition	9.789130e-07	6.009
R-HSA-453274	Mitotic G2-G2/M phases	1.051898e-06	5.978
R-HSA-5617833	Cilium Assembly	1.129481e-06	5.947
R-HSA-1280218	Adaptive Immune System	1.234645e-06	5.908
R-HSA-68877	Mitotic Prometaphase	1.254994e-06	5.901
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	1.392222e-06	5.856
R-HSA-597592	Post-translational protein modification	1.524307e-06	5.817
R-HSA-389948	Co-inhibition by PD-1	1.594955e-06	5.797
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	1.594955e-06	5.797
R-HSA-446728	Cell junction organization	1.604057e-06	5.795
R-HSA-948021	Transport to the Golgi and subsequent modification	1.705418e-06	5.768
R-HSA-5663205	Infectious disease	2.045982e-06	5.689
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	2.436855e-06	5.613
R-HSA-68882	Mitotic Anaphase	2.761946e-06	5.559
R-HSA-2555396	Mitotic Metaphase and Anaphase	2.848749e-06	5.545
R-HSA-418990	Adherens junctions interactions	2.937862e-06	5.532
R-HSA-8878171	Transcriptional regulation by RUNX1	3.740091e-06	5.427
R-HSA-8953897	Cellular responses to stimuli	3.902410e-06	5.409
R-HSA-5610787	Hedgehog 'off' state	3.904034e-06	5.408
R-HSA-8939211	ESR-mediated signaling	5.141555e-06	5.289
R-HSA-157118	Signaling by NOTCH	5.593195e-06	5.252
R-HSA-9734779	Developmental Cell Lineages of the Integumentary System	6.073499e-06	5.217
R-HSA-421270	Cell-cell junction organization	7.548368e-06	5.122
R-HSA-388841	Regulation of T cell activation by CD28 family	8.612111e-06	5.065
R-HSA-9734767	Developmental Cell Lineages	1.031243e-05	4.987
R-HSA-9927426	Developmental Lineage of Mammary Gland Alveolar Cells	1.828654e-05	4.738
R-HSA-195721	Signaling by WNT	2.369402e-05	4.625
R-HSA-5358351	Signaling by Hedgehog	2.550954e-05	4.593
R-HSA-1852241	Organelle biogenesis and maintenance	3.797362e-05	4.421
R-HSA-212165	Epigenetic regulation of gene expression	4.038716e-05	4.394
R-HSA-112315	Transmission across Chemical Synapses	4.038716e-05	4.394
R-HSA-73894	DNA Repair	8.237061e-05	4.084
R-HSA-9006931	Signaling by Nuclear Receptors	8.696246e-05	4.061
R-HSA-392499	Metabolism of proteins	1.104177e-04	3.957
R-HSA-913531	Interferon Signaling	1.254458e-04	3.902
R-HSA-1643685	Disease	1.317557e-04	3.880
R-HSA-446203	Asparagine N-linked glycosylation	2.342666e-04	3.630
R-HSA-112316	Neuronal System	4.520899e-04	3.345
R-HSA-390522	Striated Muscle Contraction	4.717810e-04	3.326
R-HSA-422475	Axon guidance	1.165780e-03	2.933
R-HSA-9675108	Nervous system development	1.738439e-03	2.760
R-HSA-199991	Membrane Trafficking	3.297129e-03	2.482
R-HSA-9938206	Developmental Lineage of Mammary Stem Cells	5.004733e-03	2.301
R-HSA-3214842	HDMs demethylate histones	6.090927e-03	2.215
R-HSA-9927432	Developmental Lineage of Mammary Gland Myoepithelial Cells	7.690599e-03	2.114
R-HSA-109582	Hemostasis	9.778809e-03	2.010
R-HSA-168256	Immune System	1.119000e-02	1.951
R-HSA-5653656	Vesicle-mediated transport	1.154038e-02	1.938
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	2.906127e-02	1.537
R-HSA-380259	Loss of Nlp from mitotic centrosomes	2.906127e-02	1.537
R-HSA-8854518	AURKA Activation by TPX2	3.134672e-02	1.504
R-HSA-9925563	Developmental Lineage of Pancreatic Ductal Cells	3.370104e-02	1.472
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	3.694424e-02	1.432
R-HSA-380287	Centrosome maturation	3.860931e-02	1.413
R-HSA-446107	Type I hemidesmosome assembly	4.017102e-02	1.396
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	4.644528e-02	1.333
R-HSA-1280215	Cytokine Signaling in Immune system	4.960837e-02	1.304
R-HSA-162582	Signal Transduction	5.017410e-02	1.300
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	5.290785e-02	1.276
R-HSA-397014	Muscle contraction	5.582621e-02	1.253
R-HSA-373753	Nephrin family interactions	8.900943e-02	1.051
R-HSA-9821993	Replacement of protamines by nucleosomes in the male pronucleus	1.058526e-01	0.975
R-HSA-9820448	Developmental Cell Lineages of the Exocrine Pancreas	1.323641e-01	0.878
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	1.514014e-01	0.820
R-HSA-9725554	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	1.577193e-01	0.802
R-HSA-5674135	MAP2K and MAPK activation	1.671094e-01	0.777
R-HSA-9656223	Signaling by RAF1 mutants	1.671094e-01	0.777
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	1.702166e-01	0.769
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	1.825315e-01	0.739
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	1.825315e-01	0.739
R-HSA-9649948	Signaling downstream of RAS mutants	1.825315e-01	0.739
R-HSA-6802949	Signaling by RAS mutants	1.825315e-01	0.739
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	1.886213e-01	0.724
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	2.006676e-01	0.698
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	2.213267e-01	0.655
R-HSA-212436	Generic Transcription Pathway	2.289448e-01	0.640
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	2.386160e-01	0.622
R-HSA-5693606	DNA Double Strand Break Response	2.442947e-01	0.612
R-HSA-69473	G2/M DNA damage checkpoint	2.638444e-01	0.579
R-HSA-8852135	Protein ubiquitination	2.665962e-01	0.574
R-HSA-5693607	Processing of DNA double-strand break ends	2.828964e-01	0.548
R-HSA-6802957	Oncogenic MAPK signaling	2.935648e-01	0.532
R-HSA-73857	RNA Polymerase II Transcription	3.059648e-01	0.514
R-HSA-422356	Regulation of insulin secretion	3.346994e-01	0.475
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	3.758248e-01	0.425
R-HSA-5693538	Homology Directed Repair	3.897342e-01	0.409
R-HSA-114608	Platelet degranulation	4.122424e-01	0.385
R-HSA-69481	G2/M Checkpoints	4.122424e-01	0.385
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	4.275103e-01	0.369
R-HSA-163685	Integration of energy metabolism	4.360590e-01	0.360
R-HSA-9664417	Leishmania phagocytosis	4.444822e-01	0.352
R-HSA-9664422	FCGR3A-mediated phagocytosis	4.444822e-01	0.352
R-HSA-9664407	Parasite infection	4.444822e-01	0.352
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	4.465685e-01	0.350
R-HSA-74160	Gene expression (Transcription)	4.667999e-01	0.331
R-HSA-5693532	DNA Double-Strand Break Repair	4.730004e-01	0.325
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	5.149314e-01	0.288
R-HSA-69620	Cell Cycle Checkpoints	6.482650e-01	0.188
R-HSA-76002	Platelet activation, signaling and aggregation	6.689784e-01	0.175
R-HSA-9824443	Parasitic Infection Pathways	6.776588e-01	0.169
R-HSA-9658195	Leishmania infection	6.776588e-01	0.169
R-HSA-5673001	RAF/MAP kinase cascade	6.873054e-01	0.163
R-HSA-5684996	MAPK1/MAPK3 signaling	6.955129e-01	0.158
R-HSA-5683057	MAPK family signaling cascades	7.492429e-01	0.125
R-HSA-6798695	Neutrophil degranulation	8.360188e-01	0.078
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	8.688139e-01	0.061
R-HSA-168249	Innate Immune System	9.660621e-01	0.015
R-HSA-1430728	Metabolism	9.999999e-01	0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
PAK6	0.530	0.251	-2	0.555
MNK1	0.518	0.214	-2	0.464
CDK10	0.518	0.186	1	0.548
PKCI	0.517	0.237	2	0.546
PHKG2	0.516	0.206	-3	0.559
AURC	0.515	0.174	-2	0.470
CDK14	0.515	0.194	1	0.547
NLK	0.514	0.231	1	0.592
PKCZ	0.514	0.233	2	0.535
CDK16	0.514	0.195	1	0.511
PKCH	0.513	0.216	2	0.514
PKCG	0.512	0.186	2	0.504
PKN2	0.512	0.208	-3	0.531
HIPK2	0.512	0.160	1	0.599
PKCE	0.512	0.207	2	0.512
WNK1	0.511	0.217	-2	0.441
PAK4	0.511	0.190	-2	0.521
PHKG1	0.510	0.184	-3	0.527
PKCT	0.510	0.199	2	0.502
CLK1	0.510	0.145	-3	0.495
MNK2	0.509	0.178	-2	0.471
MELK	0.509	0.180	-3	0.548
PKCD	0.509	0.188	2	0.492
PKN3	0.509	0.205	-3	0.471
PAK5	0.509	0.183	-2	0.518
PKN1	0.508	0.178	-3	0.474
AMPKA2	0.508	0.171	-3	0.535
PKCB	0.508	0.171	2	0.521
HIPK4	0.507	0.130	1	0.623
CDK18	0.507	0.154	1	0.522
AKT1	0.507	0.157	-3	0.460
PKCA	0.507	0.179	2	0.512
HIPK3	0.506	0.157	1	0.642
DYRK3	0.506	0.163	1	0.648
CDKL5	0.505	0.094	-3	0.435
AMPKA1	0.505	0.182	-3	0.543
CDK5	0.505	0.165	1	0.531
HIPK1	0.505	0.158	1	0.625
AURB	0.504	0.160	-2	0.473
DYRK2	0.504	0.145	1	0.628
PAK3	0.503	0.151	-2	0.505
ERK7	0.503	0.210	2	0.551
PKG2	0.503	0.142	-2	0.449
CDK7	0.503	0.134	1	0.535
MST4	0.503	0.132	2	0.494
CDK9	0.502	0.141	1	0.553
CDK6	0.502	0.174	1	0.540
IRE1	0.502	0.164	1	0.489
RSK3	0.502	0.085	-3	0.446
AKT2	0.502	0.116	-3	0.431
ERK5	0.501	0.124	1	0.514
TSSK1	0.501	0.150	-3	0.555
PKACG	0.501	0.118	-2	0.442
CLK4	0.501	0.135	-3	0.475
NUAK2	0.501	0.118	-3	0.523
SRPK1	0.501	0.074	-3	0.417
CDK4	0.500	0.170	1	0.534
MAPKAPK3	0.500	0.074	-3	0.512
DYRK1A	0.500	0.128	1	0.594
CDK19	0.500	0.124	1	0.516
ERK1	0.500	0.148	1	0.556
CDK17	0.499	0.143	1	0.509
PAK1	0.499	0.142	-2	0.508
SGK3	0.499	0.146	-3	0.472
SIK	0.499	0.116	-3	0.498
ERK2	0.499	0.151	1	0.575
QIK	0.498	0.134	-3	0.526
SSTK	0.498	0.187	4	0.455
ICK	0.498	0.118	-3	0.467
RSK2	0.497	0.075	-3	0.460
MOK	0.497	0.155	1	0.634
AKT3	0.497	0.113	-3	0.383
ULK2	0.497	0.106	2	0.473
DYRK1B	0.497	0.130	1	0.568
CAMK4	0.497	0.145	-3	0.532
NIM1	0.497	0.102	3	0.436
P38A	0.497	0.157	1	0.568
CLK3	0.497	0.102	1	0.487
NUAK1	0.497	0.090	-3	0.515
CDK3	0.496	0.143	1	0.509
RIPK3	0.496	0.111	3	0.401
CDK8	0.495	0.115	1	0.530
PRKD2	0.495	0.058	-3	0.518
CDKL1	0.495	0.074	-3	0.430
PKACB	0.495	0.122	-2	0.437
QSK	0.495	0.113	4	0.493
PRKX	0.494	0.109	-3	0.448
TSSK2	0.494	0.126	-5	0.392
WNK3	0.494	0.095	1	0.472
GCN2	0.493	0.037	2	0.494
P38B	0.493	0.152	1	0.549
P38G	0.493	0.145	1	0.514
BRSK2	0.493	0.089	-3	0.545
NDR1	0.493	0.057	-3	0.505
JNK2	0.493	0.152	1	0.552
NEK2	0.493	0.171	2	0.552
P90RSK	0.492	0.047	-3	0.448
MLK3	0.492	0.137	2	0.511
CDK13	0.491	0.108	1	0.543
CDK12	0.491	0.114	1	0.546
MARK3	0.491	0.129	4	0.495
PRKD3	0.490	0.054	-3	0.498
IRE2	0.490	0.122	2	0.459
MLK1	0.490	0.107	2	0.536
CAMK1G	0.490	0.092	-3	0.480
PKACA	0.490	0.113	-2	0.439
MLK2	0.490	0.148	2	0.502
IRAK4	0.490	0.181	1	0.493
CHAK1	0.490	0.109	2	0.472
SNRK	0.489	0.065	2	0.378
PAK2	0.489	0.116	-2	0.511
WNK4	0.489	0.151	-2	0.435
RAF1	0.489	0.070	1	0.451
MTOR	0.489	0.016	1	0.534
NEK9	0.489	0.120	2	0.543
ULK1	0.489	0.037	-3	0.462
MARK4	0.489	0.097	4	0.472
DYRK4	0.488	0.115	1	0.575
PKG1	0.488	0.108	-2	0.447
NIK	0.488	0.181	-3	0.529
CDK1	0.488	0.120	1	0.536
HUNK	0.488	0.092	2	0.505
P70S6KB	0.487	0.061	-3	0.493
CDK2	0.487	0.109	1	0.560
SRPK2	0.487	0.030	-3	0.369
NEK6	0.487	0.057	-2	0.287
AURA	0.486	0.124	-2	0.470
CAMK1B	0.486	0.079	-3	0.517
NDR2	0.486	0.003	-3	0.492
P38D	0.486	0.145	1	0.485
MAK	0.486	0.123	-2	0.521
RSK4	0.486	0.055	-3	0.429
TBK1	0.486	0.025	1	0.443
COT	0.486	-0.002	2	0.464
CLK2	0.485	0.086	-3	0.461
BRSK1	0.485	0.065	-3	0.510
MSK2	0.484	0.049	-3	0.411
PIM2	0.483	0.067	-3	0.464
MARK1	0.483	0.113	4	0.483
CDC7	0.483	-0.007	1	0.369
CAMLCK	0.483	0.107	-2	0.482
MYLK4	0.482	0.094	-2	0.464
P70S6K	0.482	0.045	-3	0.434
NEK7	0.482	0.038	-3	0.476
PRKD1	0.482	0.007	-3	0.520
MRCKB	0.482	0.128	-3	0.485
IKKE	0.481	-0.004	1	0.427
PIM3	0.481	0.009	-3	0.469
JNK3	0.481	0.126	1	0.562
SKMLCK	0.481	0.078	-2	0.444
PIM1	0.480	0.042	-3	0.462
LATS2	0.480	-0.000	-5	0.323
KIS	0.480	0.059	1	0.567
MAPKAPK2	0.480	0.007	-3	0.459
MARK2	0.479	0.101	4	0.447
IKKB	0.479	-0.037	-2	0.384
MLK4	0.479	0.083	2	0.519
CAMK1A	0.479	0.085	-3	0.443
MST3	0.479	0.163	2	0.544
CHAK2	0.478	-0.001	-1	0.489
PRPK	0.478	-0.038	-1	0.477
MASTL	0.478	0.037	-2	0.383
LOK	0.477	0.180	-2	0.449
SGK1	0.477	0.077	-3	0.363
DCAMKL2	0.477	0.093	-3	0.560
CHK1	0.477	0.050	-3	0.517
SRPK3	0.477	0.008	-3	0.374
DAPK2	0.477	0.073	-3	0.511
PDHK1	0.477	-0.036	1	0.482
DCAMKL1	0.477	0.091	-3	0.534
MSK1	0.476	0.053	-3	0.431
PDHK4	0.475	-0.099	1	0.498
PKR	0.475	0.147	1	0.493
ATR	0.474	-0.023	1	0.431
RIPK1	0.474	0.009	1	0.557
BUB1	0.474	0.105	-5	0.300
TGFBR2	0.474	-0.041	-2	0.248
ROCK2	0.472	0.140	-3	0.503
TTBK2	0.472	-0.045	2	0.480
PLK4	0.472	0.039	2	0.376
ROCK1	0.472	0.144	-3	0.495
DRAK1	0.472	0.049	1	0.492
MRCKA	0.472	0.099	-3	0.486
PINK1	0.471	0.041	1	0.530
CAMK1D	0.471	0.059	-3	0.470
IRAK1	0.470	0.059	-1	0.395
CAMK2G	0.470	-0.041	2	0.354
CHK2	0.470	0.044	-3	0.429
ANKRD3	0.470	0.045	1	0.527
CAMK2D	0.469	-0.030	-3	0.522
SMMLCK	0.469	0.082	-3	0.489
PERK	0.469	0.046	-2	0.331
BCKDK	0.468	-0.067	-1	0.366
MOS	0.468	-0.067	1	0.433
DSTYK	0.468	-0.068	2	0.499
DMPK1	0.468	0.149	-3	0.501
SLK	0.467	0.101	-2	0.407
DLK	0.467	-0.034	1	0.474
PRP4	0.467	0.043	-3	0.358
MEK1	0.466	0.045	2	0.491
YSK4	0.466	0.038	1	0.422
STK33	0.465	0.027	2	0.350
MAPKAPK5	0.464	-0.061	-3	0.419
ZAK	0.464	0.055	1	0.473
MPSK1	0.464	0.062	1	0.459
NEK8	0.464	0.122	2	0.510
MEK5	0.464	0.067	2	0.488
LATS1	0.464	0.009	-3	0.480
NEK5	0.463	0.088	1	0.475
TAO2	0.463	0.132	2	0.500
SBK	0.463	0.022	-3	0.377
TAO3	0.463	0.097	1	0.461
GRK5	0.463	-0.095	-3	0.420
HRI	0.463	0.005	-2	0.306
YSK1	0.463	0.156	2	0.539
IKKA	0.463	-0.054	-2	0.343
LIMK2_TYR	0.463	0.203	-3	0.548
NEK4	0.462	0.116	1	0.454
BMPR2	0.462	-0.197	-2	0.355
TTBK1	0.462	-0.044	2	0.387
NEK3	0.462	0.098	1	0.480
HASPIN	0.462	0.084	-1	0.476
JNK1	0.462	0.090	1	0.534
MEKK1	0.460	0.028	1	0.472
NEK11	0.460	0.079	1	0.514
LKB1	0.460	0.091	-3	0.491
CAMKK2	0.460	0.106	-2	0.491
PDK1	0.460	0.136	1	0.608
NEK1	0.459	0.160	1	0.485
CAMK2A	0.458	-0.042	2	0.339
CAMKK1	0.458	0.088	-2	0.452
VRK2	0.458	0.009	1	0.534
MEKK6	0.458	0.080	1	0.416
RIPK2	0.458	0.021	1	0.478
PLK1	0.458	-0.037	-2	0.261
GRK1	0.458	-0.066	-2	0.380
GRK6	0.457	-0.072	1	0.441
LRRK2	0.455	0.137	2	0.518
HGK	0.455	0.084	3	0.458
BRAF	0.454	0.014	-4	0.430
CRIK	0.453	0.045	-3	0.427
TAO1	0.453	0.112	1	0.447
TNIK	0.453	0.095	3	0.477
SMG1	0.453	-0.067	1	0.391
KHS1	0.452	0.084	1	0.447
MAP3K15	0.452	0.067	1	0.478
DAPK3	0.452	0.065	-3	0.501
MEKK2	0.452	0.001	2	0.497
MYO3B	0.451	0.151	2	0.521
HPK1	0.451	0.058	1	0.453
TNK1	0.451	0.099	3	0.453
MINK	0.451	0.084	1	0.439
PLK3	0.450	-0.044	2	0.362
KHS2	0.449	0.073	1	0.450
EEF2K	0.449	0.052	3	0.419
MEKK3	0.449	-0.067	1	0.475
PBK	0.449	0.033	1	0.344
TNNI3K_TYR	0.448	0.101	1	0.496
CAMK2B	0.448	-0.073	2	0.311
DAPK1	0.447	0.048	-3	0.473
DNAPK	0.447	-0.070	1	0.393
MEK2	0.446	0.040	2	0.495
ALK4	0.446	-0.097	-2	0.280
LIMK1_TYR	0.445	0.074	2	0.463
GSK3B	0.445	-0.050	4	0.104
MYO3A	0.444	0.112	1	0.474
TESK1_TYR	0.444	0.046	3	0.481
PKMYT1_TYR	0.443	0.032	3	0.481
GCK	0.443	0.007	1	0.437
CK1A2	0.442	-0.063	-3	0.188
PINK1_TYR	0.442	0.038	1	0.506
CK1E	0.441	-0.085	-3	0.207
GRK4	0.441	-0.171	-2	0.287
PDHK3_TYR	0.441	0.009	4	0.417
GRK2	0.439	-0.099	-2	0.250
CK1G1	0.439	-0.095	-3	0.191
GSK3A	0.439	-0.049	4	0.110
ATM	0.438	-0.125	1	0.381
VRK1	0.438	0.033	2	0.482
GRK7	0.438	-0.098	1	0.431
TAK1	0.438	0.019	1	0.442
DDR1	0.437	0.010	4	0.374
TYK2	0.437	0.020	1	0.485
MST1R	0.437	-0.016	3	0.497
TGFBR1	0.436	-0.102	-2	0.237
MAP2K7_TYR	0.436	-0.048	2	0.430
ROS1	0.436	-0.012	3	0.450
JAK2	0.435	-0.005	1	0.501
NEK10_TYR	0.435	0.035	1	0.432
RET	0.435	-0.019	1	0.498
JAK1	0.435	0.038	1	0.483
GAK	0.435	-0.034	1	0.424
CSF1R	0.434	-0.019	3	0.469
FAM20C	0.433	-0.090	2	0.202
CK1D	0.433	-0.085	-3	0.182
PASK	0.433	-0.085	-3	0.452
BMPR1B	0.432	-0.106	1	0.345
MST2	0.431	-0.056	1	0.422
WEE1_TYR	0.431	0.035	-1	0.368
TLK2	0.431	-0.157	1	0.416
MST1	0.431	-0.033	1	0.426
PDGFRA	0.431	-0.017	3	0.479
ACVR2A	0.431	-0.145	-2	0.244
TYRO3	0.431	-0.060	3	0.471
DDR2	0.430	0.011	3	0.410
ASK1	0.430	0.033	1	0.474
PDHK4_TYR	0.429	-0.090	2	0.395
BMPR2_TYR	0.429	-0.058	-1	0.470
OSR1	0.429	0.001	2	0.516
GRK3	0.429	-0.103	-2	0.214
PDGFRB	0.429	-0.035	3	0.464
MAP2K4_TYR	0.428	-0.158	-1	0.469
TNK2	0.428	-0.033	3	0.449
ACVR2B	0.427	-0.153	-2	0.247
JAK3	0.427	-0.040	1	0.491
YANK3	0.427	-0.053	2	0.176
FLT3	0.425	-0.037	3	0.445
KDR	0.424	-0.040	3	0.411
EPHA6	0.424	-0.055	-1	0.431
ALK2	0.423	-0.162	-2	0.254
TEK	0.423	-0.083	3	0.423
TLK1	0.423	-0.191	-2	0.218
ABL2	0.422	-0.059	-1	0.387
MAP2K6_TYR	0.422	-0.174	-1	0.483
FGFR1	0.422	-0.058	3	0.441
ABL1	0.419	-0.067	-1	0.377
TTK	0.419	-0.035	-2	0.246
AXL	0.419	-0.087	3	0.460
FGFR2	0.419	-0.100	3	0.433
PLK2	0.418	-0.081	-3	0.340
BMPR1A	0.418	-0.122	1	0.320
ALK	0.418	-0.066	3	0.420
KIT	0.417	-0.097	3	0.467
PDHK1_TYR	0.417	-0.200	-1	0.468
FLT4	0.415	-0.081	3	0.404
MUSK	0.414	-0.029	1	0.381
INSRR	0.414	-0.113	3	0.418
BIKE	0.414	-0.041	1	0.347
LCK	0.413	-0.078	-1	0.437
ITK	0.413	-0.109	-1	0.399
MET	0.412	-0.113	3	0.471
EPHA1	0.411	-0.100	3	0.453
LTK	0.411	-0.091	3	0.429
YES1	0.411	-0.131	-1	0.438
NTRK2	0.410	-0.111	3	0.452
INSR	0.410	-0.105	3	0.429
FLT1	0.410	-0.093	-1	0.389
TEC	0.409	-0.103	-1	0.349
HCK	0.409	-0.135	-1	0.430
EPHB4	0.409	-0.165	-1	0.396
FGR	0.408	-0.164	1	0.410
STLK3	0.408	-0.061	1	0.434
CK2A2	0.408	-0.116	1	0.267
CK1A	0.408	-0.112	-3	0.126
PTK6	0.407	-0.123	-1	0.338
MERTK	0.407	-0.137	3	0.439
FGFR3	0.406	-0.124	3	0.421
BTK	0.406	-0.146	-1	0.372
AAK1	0.406	-0.030	1	0.289
BLK	0.406	-0.102	-1	0.435
FRK	0.405	-0.113	-1	0.424
YANK2	0.404	-0.065	2	0.184
TXK	0.404	-0.128	1	0.371
FER	0.403	-0.199	1	0.392
PTK2B	0.403	-0.109	-1	0.381
EPHA4	0.403	-0.144	2	0.340
CK2A1	0.403	-0.122	1	0.259
NTRK1	0.402	-0.166	-1	0.390
BMX	0.402	-0.122	-1	0.368
EPHB1	0.402	-0.176	1	0.400
ERBB2	0.401	-0.143	1	0.437
SRMS	0.400	-0.193	1	0.394
MATK	0.400	-0.117	-1	0.323
EPHB3	0.400	-0.179	-1	0.380
NTRK3	0.398	-0.141	-1	0.366
EPHA7	0.398	-0.144	2	0.366
CSK	0.394	-0.151	2	0.371
LYN	0.393	-0.154	3	0.413
ALPHAK3	0.392	-0.131	-1	0.388
EPHA3	0.391	-0.180	2	0.331
CK1G3	0.391	-0.103	-3	0.100
EPHB2	0.390	-0.208	-1	0.371
IGF1R	0.389	-0.143	3	0.391
EGFR	0.389	-0.120	1	0.409
FYN	0.388	-0.153	-1	0.444
FGFR4	0.387	-0.142	-1	0.334
PTK2	0.386	-0.098	-1	0.419
SRC	0.385	-0.170	-1	0.412
EPHA8	0.384	-0.162	-1	0.373
EPHA5	0.378	-0.206	2	0.322
SYK	0.375	-0.148	-1	0.398
EPHA2	0.375	-0.170	-1	0.344
ERBB4	0.374	-0.133	1	0.374
FES	0.370	-0.167	-1	0.328
ZAP70	0.370	-0.111	-1	0.368
CK1G2	0.367	-0.131	-3	0.148