Motif 697 (n=61)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
O00512	BCL9	T172	psp	B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog)	Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269\|PubMed:11955446}.
O15234	CASC3	S373	ochoa	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)	Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269\|PubMed:17375189, ECO:0000269\|PubMed:17652158, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961}.
O75962	TRIO	S2417	ochoa	Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)	Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250\|UniProtKB:F1M0Z1, ECO:0000269\|PubMed:10341202, ECO:0000269\|PubMed:22155786, ECO:0000269\|PubMed:27418539, ECO:0000269\|PubMed:32109419, ECO:0000269\|PubMed:8643598}.
O76021	RSL1D1	S392	ochoa	Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)	Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269\|PubMed:18678645, ECO:0000269\|PubMed:22419112}.
O76021	RSL1D1	S443	ochoa	Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)	Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269\|PubMed:18678645, ECO:0000269\|PubMed:22419112}.
P07197	NEFM	S620	ochoa	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250\|UniProtKB:P08553}.
P07197	NEFM	S633	ochoa	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250\|UniProtKB:P08553}.
P07197	NEFM	S672	ochoa	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250\|UniProtKB:P08553}.
P07197	NEFM	S736	ochoa	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250\|UniProtKB:P08553}.
P10412	H1-4	T18	ochoa\|psp	Histone H1.4 (Histone H1b) (Histone H1s-4)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P10412	H1-4	T146	ochoa\|psp	Histone H1.4 (Histone H1b) (Histone H1s-4)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P10412	H1-4	S172	psp	Histone H1.4 (Histone H1b) (Histone H1s-4)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P10412	H1-4	S187	ochoa\|psp	Histone H1.4 (Histone H1b) (Histone H1s-4)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P12272	PTHLH	T121	psp	Parathyroid hormone-related protein (PTH-rP) (PTHrP) (Parathyroid hormone-like protein) (PLP) [Cleaved into: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]	Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport (PubMed:12538599, PubMed:35932760, PubMed:3616618). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed:19674967, PubMed:35932760). Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Required for skeletal homeostasis (PubMed:12538599). Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs (PubMed:12538599). Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion (By similarity). BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1 (PubMed:20637541). {ECO:0000250\|UniProtKB:P22858, ECO:0000269\|PubMed:19674967, ECO:0000269\|PubMed:20637541, ECO:0000269\|PubMed:35932760, ECO:0000269\|PubMed:3616618, ECO:0000303\|PubMed:12538599}.; FUNCTION: [Osteostatin]: Potent inhibitor of osteoclastic bone resorption. {ECO:0000269\|PubMed:1915066, ECO:0000269\|PubMed:1954916, ECO:0000269\|PubMed:20637541, ECO:0000269\|PubMed:9048639, ECO:0000269\|PubMed:9144344}.
P16401	H1-5	S18	ochoa\|psp	Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16401	H1-5	T138	ochoa\|psp	Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16401	H1-5	T155	psp	Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16401	H1-5	S173	psp	Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16401	H1-5	S189	ochoa\|psp	Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16402	H1-3	T18	ochoa	Histone H1.3 (Histone H1c) (Histone H1s-2)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16402	H1-3	T147	ochoa	Histone H1.3 (Histone H1c) (Histone H1s-2)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16402	H1-3	S189	psp	Histone H1.3 (Histone H1c) (Histone H1s-2)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16403	H1-2	T31	ochoa	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16403	H1-2	T146	ochoa\|psp	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16403	H1-2	T165	ochoa\|psp	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16403	H1-2	S173	psp	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P17677	GAP43	T107	ochoa	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46)	This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269\|PubMed:14978216, ECO:0000269\|PubMed:21152083}.
P17677	GAP43	T181	ochoa	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46)	This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269\|PubMed:14978216, ECO:0000269\|PubMed:21152083}.
P19338	NCL	S67	ochoa	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P19338	NCL	T76	ochoa\|psp	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P19338	NCL	T84	psp	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P19338	NCL	T92	ochoa	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P19338	NCL	T99	ochoa	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P19338	NCL	T106	ochoa	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P19338	NCL	T113	ochoa	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P19338	NCL	T121	ochoa\|psp	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P35251	RFC1	S360	ochoa	Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)	Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269\|PubMed:8999859, ECO:0000269\|PubMed:9488738}.
P38432	COIL	S184	psp	Coilin (p80-coilin)	Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269\|PubMed:7679389}.
P46821	MAP1B	T704	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P50914	RPL14	S139	ochoa	Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (CAG-ISL 7)	Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:32669547, ECO:0000305\|PubMed:12962325}.
P61353	RPL27	Y49	ochoa	Large ribosomal subunit protein eL27 (60S ribosomal protein L27)	Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:25424902, ECO:0000269\|PubMed:25901680, ECO:0000269\|PubMed:25957688, ECO:0000269\|PubMed:32669547, ECO:0000305\|PubMed:12962325}.
Q02539	H1-1	T152	psp	Histone H1.1 (Histone H1a)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
Q02539	H1-1	S183	psp	Histone H1.1 (Histone H1a)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
Q13428	TCOF1	T310	ochoa	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q13428	TCOF1	S381	ochoa	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q13428	TCOF1	S446	ochoa	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q13428	TCOF1	S583	ochoa	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q13428	TCOF1	S906	ochoa	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q13428	TCOF1	S1378	ochoa	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q14839	CHD4	S277	ochoa	Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)	ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250\|UniProtKB:Q6PDQ2, ECO:0000269\|PubMed:16428440, ECO:0000269\|PubMed:17626165, ECO:0000269\|PubMed:25593309, ECO:0000269\|PubMed:28977666, ECO:0000269\|PubMed:32543371, ECO:0000269\|PubMed:9804427}.
Q14978	NOLC1	S397	ochoa	Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269\|PubMed:10567578, ECO:0000269\|PubMed:26399832, ECO:0000269\|PubMed:9016786}.
Q86YV5	PRAG1	T417	ochoa	Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)	Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250\|UniProtKB:D3ZMK9, ECO:0000250\|UniProtKB:Q571I4}.
Q8IYB3	SRRM1	T846	ochoa	Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)	Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269\|PubMed:10339552, ECO:0000269\|PubMed:10668804, ECO:0000269\|PubMed:11739730, ECO:0000269\|PubMed:12600940, ECO:0000269\|PubMed:12944400, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q8N0X7	SPART	S470	ochoa	Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1)	Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy (PubMed:37443287). Lipid transfer protein required for lipid droplet degradation, including by lipophagy (PubMed:38190532). Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown (PubMed:38190532). May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). {ECO:0000269\|PubMed:20719964, ECO:0000269\|PubMed:37443287, ECO:0000269\|PubMed:38190532}.
Q9H1E3	NUCKS1	S181	ochoa\|psp	Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1)	Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269\|PubMed:26323318}.
Q9P2E9	RRBP1	T225	ochoa	Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein)	Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.
Q9P2E9	RRBP1	T275	ochoa	Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein)	Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.
Q9P2E9	RRBP1	S533	ochoa	Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein)	Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.
Q9P2E9	RRBP1	S573	ochoa	Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein)	Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.
Q9P2E9	RRBP1	S583	ochoa	Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein)	Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.
P16403	H1-2	T167	EPSD\|PSP	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.

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reactome_id	name	p	-log10_p
R-HSA-140342	Apoptosis induced DNA fragmentation	4.805190e-11	10.318
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	1.828061e-10	9.738
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	3.663494e-09	8.436
R-HSA-75153	Apoptotic execution phase	5.635259e-08	7.249
R-HSA-2559583	Cellular Senescence	1.639059e-06	5.785
R-HSA-109581	Apoptosis	1.969631e-05	4.706
R-HSA-5357801	Programmed Cell Death	5.669897e-05	4.246
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	2.572966e-04	3.590
R-HSA-2262752	Cellular responses to stress	4.849258e-04	3.314
R-HSA-422475	Axon guidance	5.404363e-04	3.267
R-HSA-9675108	Nervous system development	7.532198e-04	3.123
R-HSA-8953897	Cellular responses to stimuli	1.038603e-03	2.984
R-HSA-927802	Nonsense-Mediated Decay (NMD)	1.586718e-03	2.800
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	1.586718e-03	2.800
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	3.086585e-03	2.511
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	3.509660e-03	2.455
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	3.860079e-03	2.413
R-HSA-72187	mRNA 3'-end processing	5.634589e-03	2.249
R-HSA-3214815	HDACs deacetylate histones	6.190701e-03	2.208
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	7.170937e-03	2.144
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins	9.327170e-03	2.030
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	1.002380e-02	1.999
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	9.556864e-03	2.020
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	5.179986e-03	2.286
R-HSA-73856	RNA Polymerase II Transcription Termination	7.374903e-03	2.132
R-HSA-193648	NRAGE signals death through JNK	6.381436e-03	2.195
R-HSA-8868773	rRNA processing in the nucleus and cytosol	6.654231e-03	2.177
R-HSA-201681	TCF dependent signaling in response to WNT	6.222291e-03	2.206
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	1.002380e-02	1.999
R-HSA-376176	Signaling by ROBO receptors	8.056034e-03	2.094
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	1.224773e-02	1.912
R-HSA-73854	RNA Polymerase I Promoter Clearance	1.074294e-02	1.969
R-HSA-73864	RNA Polymerase I Transcription	1.123475e-02	1.949
R-HSA-72312	rRNA processing	1.135092e-02	1.945
R-HSA-416482	G alpha (12/13) signalling events	1.123475e-02	1.949
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	1.494806e-02	1.825
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	1.523103e-02	1.817
R-HSA-9954716	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri...	1.638598e-02	1.786
R-HSA-192823	Viral mRNA Translation	1.911714e-02	1.719
R-HSA-9842860	Regulation of endogenous retroelements	1.880476e-02	1.726
R-HSA-156902	Peptide chain elongation	1.411313e-02	1.850
R-HSA-9954709	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	1.668044e-02	1.778
R-HSA-72764	Eukaryotic Translation Termination	1.668044e-02	1.778
R-HSA-72689	Formation of a pool of free 40S subunits	1.668044e-02	1.778
R-HSA-156842	Eukaryotic Translation Elongation	1.551631e-02	1.809
R-HSA-2408557	Selenocysteine synthesis	1.849458e-02	1.733
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	1.943173e-02	1.711
R-HSA-157579	Telomere Maintenance	1.727616e-02	1.763
R-HSA-73884	Base Excision Repair	1.466741e-02	1.834
R-HSA-193704	p75 NTR receptor-mediated signalling	1.788090e-02	1.748
R-HSA-9824446	Viral Infection Pathways	1.762655e-02	1.754
R-HSA-8953854	Metabolism of RNA	1.987489e-02	1.702
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	2.071190e-02	1.684
R-HSA-195721	Signaling by WNT	2.101242e-02	1.678
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	2.103736e-02	1.677
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	2.103736e-02	1.677
R-HSA-69091	Polymerase switching	2.938261e-02	1.532
R-HSA-69109	Leading Strand Synthesis	2.938261e-02	1.532
R-HSA-73886	Chromosome Maintenance	2.617237e-02	1.582
R-HSA-72613	Eukaryotic Translation Initiation	2.440874e-02	1.612
R-HSA-72737	Cap-dependent Translation Initiation	2.440874e-02	1.612
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	2.303494e-02	1.638
R-HSA-1266738	Developmental Biology	2.436393e-02	1.613
R-HSA-5693538	Homology Directed Repair	2.510806e-02	1.600
R-HSA-5656121	Translesion synthesis by POLI	3.659683e-02	1.437
R-HSA-5655862	Translesion synthesis by POLK	3.839227e-02	1.416
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	4.197345e-02	1.377
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	4.909717e-02	1.309
R-HSA-171306	Packaging Of Telomere Ends	5.968684e-02	1.224
R-HSA-5334118	DNA methylation	6.319132e-02	1.199
R-HSA-212300	PRC2 methylates histones and DNA	7.708344e-02	1.113
R-HSA-5656169	Termination of translesion DNA synthesis	6.319132e-02	1.199
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa...	8.566465e-02	1.067
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	5.440634e-02	1.264
R-HSA-110312	Translesion synthesis by REV1	3.479815e-02	1.458
R-HSA-9948299	Ribosome-associated quality control	3.372254e-02	1.472
R-HSA-110320	Translesion Synthesis by POLH	4.375920e-02	1.359
R-HSA-9670095	Inhibition of DNA recombination at telomere	8.395460e-02	1.076
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene...	8.566465e-02	1.067
R-HSA-72163	mRNA Splicing - Major Pathway	5.961776e-02	1.225
R-HSA-5696400	Dual Incision in GG-NER	7.362920e-02	1.133
R-HSA-9843970	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	7.362920e-02	1.133
R-HSA-427359	SIRT1 negatively regulates rRNA expression	7.880588e-02	1.103
R-HSA-9820960	Respiratory syncytial virus (RSV) attachment and entry	6.668318e-02	1.176
R-HSA-174411	Polymerase switching on the C-strand of the telomere	5.616968e-02	1.250
R-HSA-73728	RNA Polymerase I Promoter Opening	5.968684e-02	1.224
R-HSA-9821002	Chromatin modifications during the maternal to zygotic transition (MZT)	8.566465e-02	1.067
R-HSA-72172	mRNA Splicing	6.511811e-02	1.186
R-HSA-418885	DCC mediated attractive signaling	3.479815e-02	1.458
R-HSA-9844594	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	8.395460e-02	1.076
R-HSA-9843743	Transcriptional regulation of brown and beige adipocyte differentiation	8.395460e-02	1.076
R-HSA-9710421	Defective pyroptosis	9.077631e-02	1.042
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	5.792985e-02	1.237
R-HSA-5693532	DNA Double-Strand Break Repair	4.030230e-02	1.395
R-HSA-69186	Lagging Strand Synthesis	4.732106e-02	1.325
R-HSA-110331	Cleavage of the damaged purine	7.880588e-02	1.103
R-HSA-73927	Depurination	8.052522e-02	1.094
R-HSA-69190	DNA strand elongation	6.842439e-02	1.165
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected ...	6.842439e-02	1.165
R-HSA-68616	Assembly of the ORC complex at the origin of replication	7.016246e-02	1.154
R-HSA-9821993	Replacement of protamines by nucleosomes in the male pronucleus	5.440634e-02	1.264
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	8.737162e-02	1.059
R-HSA-73762	RNA Polymerase I Transcription Initiation	8.907550e-02	1.050
R-HSA-373752	Netrin-1 signaling	9.247405e-02	1.034
R-HSA-168273	Influenza Viral RNA Transcription and Replication	4.115673e-02	1.386
R-HSA-9711097	Cellular response to starvation	4.245130e-02	1.372
R-HSA-73933	Resolution of Abasic Sites (AP sites)	8.566465e-02	1.067
R-HSA-3247509	Chromatin modifying enzymes	8.093782e-02	1.092
R-HSA-3928662	EPHB-mediated forward signaling	9.247405e-02	1.034
R-HSA-4839726	Chromatin organization	8.925799e-02	1.049
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	7.016246e-02	1.154
R-HSA-69306	DNA Replication	4.030230e-02	1.395
R-HSA-2408522	Selenoamino acid metabolism	4.508623e-02	1.346
R-HSA-110329	Cleavage of the damaged pyrimidine	8.907550e-02	1.050
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	3.332681e-02	1.477
R-HSA-73928	Depyrimidination	8.907550e-02	1.050
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected ...	7.362920e-02	1.133
R-HSA-168255	Influenza Infection	5.240057e-02	1.281
R-HSA-196757	Metabolism of folate and pterines	7.880588e-02	1.103
R-HSA-5663205	Infectious disease	9.245923e-02	1.034
R-HSA-73887	Death Receptor Signaling	4.072865e-02	1.390
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	9.416872e-02	1.026
R-HSA-774815	Nucleosome assembly	9.416872e-02	1.026
R-HSA-2299718	Condensation of Prophase Chromosomes	9.586033e-02	1.018
R-HSA-416476	G alpha (q) signalling events	9.782519e-02	1.010
R-HSA-162582	Signal Transduction	9.864361e-02	1.006
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	9.923440e-02	1.003
R-HSA-9031628	NGF-stimulated transcription	9.923440e-02	1.003
R-HSA-73893	DNA Damage Bypass	1.009169e-01	0.996
R-HSA-912446	Meiotic recombination	1.042727e-01	0.982
R-HSA-73772	RNA Polymerase I Promoter Escape	1.059461e-01	0.975
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	1.059461e-01	0.975
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	1.066206e-01	0.972
R-HSA-1221632	Meiotic synapsis	1.076164e-01	0.968
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	1.076164e-01	0.968
R-HSA-73929	Base-Excision Repair, AP Site Formation	1.092837e-01	0.961
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	1.126094e-01	0.948
R-HSA-6782135	Dual incision in TC-NER	1.159230e-01	0.936
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	1.175753e-01	0.930
R-HSA-180786	Extension of Telomeres	1.175753e-01	0.930
R-HSA-8943724	Regulation of PTEN gene transcription	1.192247e-01	0.924
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	1.192247e-01	0.924
R-HSA-9616222	Transcriptional regulation of granulopoiesis	1.225144e-01	0.912
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	1.290583e-01	0.889
R-HSA-5693606	DNA Double Strand Break Response	1.306869e-01	0.884
R-HSA-5685942	HDR through Homologous Recombination (HRR)	1.306869e-01	0.884
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	1.323125e-01	0.878
R-HSA-212165	Epigenetic regulation of gene expression	1.335687e-01	0.874
R-HSA-9764560	Regulation of CDH1 Gene Transcription	1.355550e-01	0.868
R-HSA-427413	NoRC negatively regulates rRNA expression	1.371719e-01	0.863
R-HSA-5578749	Transcriptional regulation by small RNAs	1.387858e-01	0.858
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	1.387858e-01	0.858
R-HSA-69473	G2/M DNA damage checkpoint	1.420049e-01	0.848
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	1.436100e-01	0.843
R-HSA-8852135	Protein ubiquitination	1.436100e-01	0.843
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	1.515925e-01	0.819
R-HSA-5693607	Processing of DNA double-strand break ends	1.531803e-01	0.815
R-HSA-977225	Amyloid fiber formation	1.531803e-01	0.815
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	1.547653e-01	0.810
R-HSA-73894	DNA Repair	1.573234e-01	0.803
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	1.579266e-01	0.802
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	1.579266e-01	0.802
R-HSA-1500620	Meiosis	1.595030e-01	0.797
R-HSA-5687128	MAPK6/MAPK4 signaling	1.595030e-01	0.797
R-HSA-9645723	Diseases of programmed cell death	1.657800e-01	0.780
R-HSA-373080	Class B/2 (Secretin family receptors)	1.689015e-01	0.772
R-HSA-1912408	Pre-NOTCH Transcription and Translation	1.704580e-01	0.768
R-HSA-2682334	EPH-Ephrin signaling	1.735626e-01	0.761
R-HSA-68867	Assembly of the pre-replicative complex	1.751107e-01	0.757
R-HSA-388396	GPCR downstream signalling	1.830340e-01	0.737
R-HSA-3214847	HATs acetylate histones	1.858689e-01	0.731
R-HSA-2559580	Oxidative Stress Induced Senescence	1.904380e-01	0.720
R-HSA-5619507	Activation of HOX genes during differentiation	1.949822e-01	0.710
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	1.949822e-01	0.710
R-HSA-9833110	RSV-host interactions	1.949822e-01	0.710
R-HSA-5696398	Nucleotide Excision Repair	1.964915e-01	0.707
R-HSA-69239	Synthesis of DNA	1.995018e-01	0.700
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	1.995018e-01	0.700
R-HSA-9700206	Signaling by ALK in cancer	1.995018e-01	0.700
R-HSA-211000	Gene Silencing by RNA	1.995018e-01	0.700
R-HSA-69002	DNA Replication Pre-Initiation	2.025013e-01	0.694
R-HSA-72766	Translation	2.041899e-01	0.690
R-HSA-1912422	Pre-NOTCH Expression and Processing	2.084676e-01	0.681
R-HSA-373760	L1CAM interactions	2.158648e-01	0.666
R-HSA-68875	Mitotic Prophase	2.217344e-01	0.654
R-HSA-372790	Signaling by GPCR	2.231297e-01	0.651
R-HSA-9816359	Maternal to zygotic transition (MZT)	2.261087e-01	0.646
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	2.304593e-01	0.637
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	2.304593e-01	0.637
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	2.304593e-01	0.637
R-HSA-69481	G2/M Checkpoints	2.333465e-01	0.632
R-HSA-187037	Signaling by NTRK1 (TRKA)	2.347861e-01	0.629
R-HSA-1474165	Reproduction	2.390895e-01	0.621
R-HSA-9843745	Adipogenesis	2.405188e-01	0.619
R-HSA-9018519	Estrogen-dependent gene expression	2.490399e-01	0.604
R-HSA-6807070	PTEN Regulation	2.532658e-01	0.596
R-HSA-69242	S Phase	2.671866e-01	0.573
R-HSA-166520	Signaling by NTRKs	2.671866e-01	0.573
R-HSA-9679191	Potential therapeutics for SARS	2.699405e-01	0.569
R-HSA-1643685	Disease	2.741784e-01	0.562
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	2.754183e-01	0.560
R-HSA-5633007	Regulation of TP53 Activity	2.835606e-01	0.547
R-HSA-69278	Cell Cycle, Mitotic	2.992251e-01	0.524
R-HSA-418555	G alpha (s) signalling events	2.995807e-01	0.523
R-HSA-9909648	Regulation of PD-L1(CD274) expression	3.009000e-01	0.522
R-HSA-5689880	Ub-specific processing proteases	3.022168e-01	0.520
R-HSA-9764265	Regulation of CDH1 Expression and Function	3.022168e-01	0.520
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	3.022168e-01	0.520
R-HSA-9609690	HCMV Early Events	3.318513e-01	0.479
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	3.318513e-01	0.479
R-HSA-71291	Metabolism of amino acids and derivatives	3.352899e-01	0.475
R-HSA-389948	Co-inhibition by PD-1	3.368793e-01	0.473
R-HSA-418990	Adherens junctions interactions	3.602674e-01	0.443
R-HSA-8878171	Transcriptional regulation by RUNX1	3.698746e-01	0.432
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	3.746257e-01	0.426
R-HSA-8939211	ESR-mediated signaling	3.828571e-01	0.417
R-HSA-157118	Signaling by NOTCH	3.863526e-01	0.413
R-HSA-1640170	Cell Cycle	3.965074e-01	0.402
R-HSA-9609646	HCMV Infection	3.978668e-01	0.400
R-HSA-73857	RNA Polymerase II Transcription	3.986730e-01	0.399
R-HSA-421270	Cell-cell junction organization	3.990067e-01	0.399
R-HSA-5688426	Deubiquitination	4.035453e-01	0.394
R-HSA-388841	Regulation of T cell activation by CD28 family	4.046748e-01	0.393
R-HSA-69620	Cell Cycle Checkpoints	4.069275e-01	0.390
R-HSA-446728	Cell junction organization	4.290064e-01	0.368
R-HSA-1257604	PIP3 activates AKT signaling	4.471469e-01	0.350
R-HSA-1500931	Cell-Cell communication	4.687876e-01	0.329
R-HSA-9006925	Intracellular signaling by second messengers	4.944481e-01	0.306
R-HSA-5683057	MAPK family signaling cascades	4.992435e-01	0.302
R-HSA-9006931	Signaling by Nuclear Receptors	5.142951e-01	0.289
R-HSA-196854	Metabolism of vitamins and cofactors	5.152212e-01	0.288
R-HSA-74160	Gene expression (Transcription)	5.171300e-01	0.286
R-HSA-68886	M Phase	5.324955e-01	0.274
R-HSA-3700989	Transcriptional Regulation by TP53	6.012281e-01	0.221
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	6.378037e-01	0.195
R-HSA-9679506	SARS-CoV Infections	6.647083e-01	0.177
R-HSA-500792	GPCR ligand binding	6.860490e-01	0.164
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	7.003161e-01	0.155
R-HSA-212436	Generic Transcription Pathway	8.054976e-01	0.094
R-HSA-392499	Metabolism of proteins	8.516506e-01	0.070
R-HSA-1280218	Adaptive Immune System	8.721309e-01	0.059
R-HSA-597592	Post-translational protein modification	9.633170e-01	0.016
R-HSA-1430728	Metabolism	9.827969e-01	0.008
R-HSA-168256	Immune System	9.967029e-01	0.001

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
CDK3	0.663	0.751	1	0.836
CDK5	0.631	0.661	1	0.738
CDK1	0.625	0.671	1	0.793
CDK16	0.624	0.604	1	0.830
CDK18	0.619	0.596	1	0.815
CDK10	0.616	0.583	1	0.791
P38G	0.613	0.583	1	0.852
CDK17	0.613	0.592	1	0.845
CDK6	0.612	0.609	1	0.793
CDK2	0.611	0.695	1	0.667
JNK2	0.605	0.573	1	0.807
CDK4	0.601	0.572	1	0.819
CLK3	0.601	0.499	1	0.481
HIPK2	0.601	0.501	1	0.800
CDK14	0.599	0.559	1	0.774
P38D	0.596	0.534	1	0.851
ERK1	0.595	0.541	1	0.790
CDK7	0.595	0.556	1	0.765
HIPK1	0.594	0.465	1	0.698
CDK9	0.594	0.558	1	0.782
JNK3	0.592	0.547	1	0.782
P38B	0.591	0.525	1	0.775
CLK1	0.591	0.394	-3	0.420
CDK12	0.590	0.541	1	0.809
CDK13	0.589	0.544	1	0.788
P38A	0.588	0.521	1	0.706
MAK	0.583	0.339	-2	0.581
CLK2	0.579	0.317	-3	0.388
SRPK1	0.579	0.276	-3	0.396
CDK8	0.578	0.519	1	0.769
CDK19	0.578	0.515	1	0.805
JNK1	0.577	0.480	1	0.807
HIPK3	0.577	0.436	1	0.661
ERK2	0.577	0.530	1	0.746
NLK	0.575	0.534	1	0.499
CLK4	0.575	0.320	-3	0.406
DYRK1B	0.574	0.457	1	0.768
MOK	0.572	0.315	1	0.582
DYRK2	0.571	0.450	1	0.713
ERK7	0.570	0.257	2	0.529
MST4	0.569	0.240	2	0.713
PKCB	0.565	0.204	2	0.667
DYRK1A	0.565	0.370	1	0.676
KIS	0.563	0.462	1	0.744
SRPK2	0.563	0.218	-3	0.320
PKCE	0.563	0.204	2	0.650
DYRK4	0.562	0.450	1	0.808
HIPK4	0.561	0.297	1	0.504
PKCD	0.559	0.180	2	0.638
MST3	0.559	0.200	2	0.701
WNK1	0.559	0.161	-2	0.691
PRP4	0.558	0.301	-3	0.477
PKCA	0.557	0.161	2	0.653
CDKL5	0.557	0.156	-3	0.419
ICK	0.557	0.255	-3	0.451
ERK5	0.553	0.246	1	0.406
DYRK3	0.553	0.320	1	0.662
PKCZ	0.551	0.164	2	0.638
TNIK	0.551	0.230	3	0.470
PKCG	0.551	0.163	2	0.634
CDKL1	0.551	0.126	-3	0.410
PKR	0.551	0.137	1	0.141
MPSK1	0.550	0.109	1	0.184
PKCH	0.550	0.150	2	0.623
PKN2	0.549	0.119	-3	0.473
PKCI	0.549	0.161	2	0.635
CHAK2	0.549	0.169	-1	0.657
SRPK3	0.547	0.148	-3	0.338
NIK	0.545	0.114	-3	0.485
EEF2K	0.545	0.173	3	0.486
HASPIN	0.545	0.092	-1	0.503
MLK3	0.545	0.133	2	0.648
MNK2	0.544	0.129	-2	0.605
SGK3	0.544	0.065	-3	0.434
IRE1	0.544	0.094	1	0.126
PKCT	0.544	0.124	2	0.625
MNK1	0.543	0.145	-2	0.620
IRAK4	0.542	0.103	1	0.108
PIM1	0.542	0.085	-3	0.393
PKN3	0.542	0.045	-3	0.437
TAO3	0.541	0.124	1	0.140
KHS2	0.541	0.137	1	0.122
HGK	0.540	0.146	3	0.430
TAO2	0.540	0.142	2	0.670
COT	0.539	0.040	2	0.603
NEK2	0.539	0.056	2	0.654
AKT2	0.539	0.066	-3	0.368
NUAK2	0.539	0.069	-3	0.468
MTOR	0.539	0.170	1	0.289
KHS1	0.538	0.112	1	0.112
BUB1	0.538	0.083	-5	0.343
LOK	0.537	0.138	-2	0.560
YSK1	0.537	0.106	2	0.686
ROCK2	0.537	0.086	-3	0.433
PRPK	0.537	-0.014	-1	0.543
DCAMKL1	0.536	0.065	-3	0.451
NEK6	0.536	0.057	-2	0.680
MEKK6	0.536	0.075	1	0.116
MLK2	0.535	0.022	2	0.626
WNK4	0.535	0.028	-2	0.683
P70S6KB	0.535	0.047	-3	0.423
CHAK1	0.534	0.118	2	0.562
AMPKA1	0.534	0.043	-3	0.488
IRE2	0.534	0.052	2	0.565
GSK3A	0.534	0.111	4	0.259
CAMLCK	0.533	-0.003	-2	0.642
AURC	0.533	0.075	-2	0.512
ULK2	0.533	0.034	2	0.544
RSK2	0.532	0.030	-3	0.420
PKG2	0.532	0.066	-2	0.553
MINK	0.532	0.102	1	0.097
LATS1	0.532	0.024	-3	0.449
NEK9	0.532	-0.005	2	0.662
CAMK1B	0.532	-0.001	-3	0.475
VRK2	0.531	0.032	1	0.217
PIM2	0.531	0.056	-3	0.403
MOS	0.531	-0.046	1	0.156
GRK7	0.531	0.008	1	0.127
MLK1	0.531	0.013	2	0.656
PHKG1	0.531	0.065	-3	0.452
BMPR2	0.530	-0.098	-2	0.692
LRRK2	0.530	0.134	2	0.622
NEK5	0.530	0.007	1	0.108
PIM3	0.530	0.017	-3	0.430
MRCKB	0.530	0.066	-3	0.402
AKT3	0.530	0.064	-3	0.329
MAP3K15	0.530	0.029	1	0.118
RSK3	0.530	0.033	-3	0.409
NDR1	0.529	0.061	-3	0.443
HPK1	0.529	0.065	1	0.114
PBK	0.529	0.039	1	0.141
MEKK2	0.528	-0.016	2	0.591
SGK1	0.528	0.046	-3	0.300
PRKD3	0.528	0.045	-3	0.438
DMPK1	0.527	0.067	-3	0.423
NEK1	0.527	0.020	1	0.095
AKT1	0.527	0.041	-3	0.391
AMPKA2	0.527	0.028	-3	0.462
SKMLCK	0.527	-0.039	-2	0.674
MYO3B	0.527	0.115	2	0.673
RSK4	0.527	0.035	-3	0.370
TSSK1	0.526	0.021	-3	0.514
DSTYK	0.526	-0.043	2	0.656
PAK6	0.525	0.068	-2	0.480
ZAK	0.525	-0.007	1	0.110
TAO1	0.525	0.097	1	0.116
MYO3A	0.525	0.134	1	0.128
GCK	0.525	0.053	1	0.112
NEK4	0.525	-0.005	1	0.099
PKACG	0.525	0.047	-2	0.587
AAK1	0.524	0.048	1	0.163
NEK11	0.524	-0.003	1	0.131
ATR	0.524	-0.067	1	0.157
SSTK	0.524	0.063	4	0.423
PKN1	0.524	0.044	-3	0.409
NEK7	0.524	-0.036	-3	0.449
PRKD2	0.524	0.051	-3	0.455
DAPK2	0.523	-0.060	-3	0.484
GAK	0.523	0.007	1	0.160
TGFBR2	0.523	0.004	-2	0.671
PHKG2	0.523	0.075	-3	0.473
MELK	0.523	0.015	-3	0.466
DCAMKL2	0.523	0.031	-3	0.469
MARK4	0.523	-0.019	4	0.462
BMPR1B	0.523	-0.026	1	0.085
SLK	0.523	0.091	-2	0.507
ALK4	0.522	-0.032	-2	0.720
PDK1	0.522	-0.025	1	0.148
ROCK1	0.522	0.052	-3	0.406
YSK4	0.522	-0.049	1	0.091
HRI	0.522	-0.004	-2	0.672
ANKRD3	0.521	-0.094	1	0.122
TSSK2	0.521	-0.006	-5	0.431
MEK5	0.521	-0.054	2	0.567
PAK1	0.521	0.003	-2	0.577
PERK	0.520	-0.035	-2	0.659
MRCKA	0.520	0.073	-3	0.395
NIM1	0.520	0.002	3	0.270
MLK4	0.520	-0.005	2	0.581
LKB1	0.520	-0.005	-3	0.478
RIPK3	0.519	-0.083	3	0.231
P90RSK	0.519	-0.008	-3	0.410
MEKK1	0.519	-0.080	1	0.122
WNK3	0.518	-0.070	1	0.110
ULK1	0.518	-0.015	-3	0.438
NEK3	0.518	-0.002	1	0.125
PKACB	0.517	0.031	-2	0.529
TGFBR1	0.517	-0.044	-2	0.708
PAK3	0.517	-0.012	-2	0.567
BIKE	0.517	0.019	1	0.153
PRKD1	0.517	-0.002	-3	0.498
QIK	0.516	-0.016	-3	0.479
CRIK	0.516	0.029	-3	0.384
PINK1	0.516	0.095	1	0.333
NDR2	0.516	0.023	-3	0.443
PRKX	0.516	0.066	-3	0.361
GSK3B	0.516	0.018	4	0.250
CDC7	0.516	-0.099	1	0.111
RAF1	0.515	-0.166	1	0.101
NUAK1	0.515	0.010	-3	0.418
HUNK	0.515	-0.097	2	0.545
NEK8	0.514	-0.041	2	0.627
AURB	0.513	0.006	-2	0.493
MST1	0.513	0.016	1	0.094
MEK1	0.513	-0.137	2	0.526
GRK5	0.512	-0.138	-3	0.455
MEKK3	0.512	-0.106	1	0.112
PLK4	0.512	-0.040	2	0.317
CAMK2G	0.512	-0.111	2	0.463
OSR1	0.511	0.028	2	0.586
DLK	0.511	-0.164	1	0.121
TTBK2	0.511	-0.105	2	0.513
PDHK4	0.511	-0.216	1	0.171
BRAF	0.511	-0.117	-4	0.459
SMMLCK	0.511	-0.037	-3	0.442
MAPKAPK3	0.510	-0.047	-3	0.440
CAMKK2	0.510	-0.068	-2	0.515
PASK	0.510	-0.059	-3	0.442
RIPK1	0.510	-0.161	1	0.107
MST2	0.510	-0.048	1	0.097
QSK	0.510	-0.026	4	0.438
TBK1	0.510	-0.143	1	0.082
DNAPK	0.509	-0.059	1	0.139
VRK1	0.509	-0.105	2	0.577
PDHK1	0.509	-0.194	1	0.152
DRAK1	0.509	-0.073	1	0.070
LATS2	0.509	-0.013	-5	0.409
CAMKK1	0.508	-0.084	-2	0.509
ASK1	0.508	-0.026	1	0.119
MARK3	0.508	-0.019	4	0.388
SIK	0.508	-0.017	-3	0.407
MYLK4	0.507	-0.033	-2	0.573
ALK2	0.507	-0.083	-2	0.695
CAMK2D	0.506	-0.103	-3	0.480
PKACA	0.506	0.013	-2	0.509
CAMK1G	0.506	-0.013	-3	0.395
P70S6K	0.506	-0.010	-3	0.366
STK33	0.506	-0.001	2	0.364
GRK1	0.506	-0.070	-2	0.575
TAK1	0.505	-0.095	1	0.087
TLK2	0.504	-0.134	1	0.100
ACVR2A	0.504	-0.092	-2	0.662
MASTL	0.503	-0.199	-2	0.585
GCN2	0.503	-0.116	2	0.544
DAPK3	0.502	-0.054	-3	0.428
TTK	0.502	-0.042	-2	0.640
ACVR2B	0.501	-0.112	-2	0.671
IKKE	0.500	-0.173	1	0.082
CAMK2A	0.500	-0.062	2	0.455
PLK1	0.500	-0.147	-2	0.603
BRSK2	0.500	-0.035	-3	0.469
CHK2	0.499	-0.031	-3	0.351
PAK2	0.499	-0.070	-2	0.544
BMPR1A	0.499	-0.071	1	0.079
GRK6	0.499	-0.176	1	0.100
MARK2	0.498	-0.073	4	0.374
CK1E	0.498	-0.038	-3	0.221
CHK1	0.497	-0.098	-3	0.443
TLK1	0.497	-0.134	-2	0.684
MAPKAPK2	0.496	-0.059	-3	0.378
CAMK4	0.496	-0.098	-3	0.445
MEK2	0.496	-0.135	2	0.527
SBK	0.496	0.024	-3	0.297
SMG1	0.496	-0.101	1	0.145
PAK5	0.495	-0.006	-2	0.417
BRSK1	0.494	-0.045	-3	0.435
MARK1	0.492	-0.080	4	0.397
MSK2	0.492	-0.065	-3	0.370
BCKDK	0.492	-0.155	-1	0.432
DAPK1	0.491	-0.071	-3	0.410
CAMK1D	0.491	-0.045	-3	0.362
IKKB	0.491	-0.191	-2	0.514
GRK2	0.490	-0.105	-2	0.549
ATM	0.489	-0.124	1	0.121
PAK4	0.489	-0.003	-2	0.422
CAMK1A	0.489	-0.032	-3	0.353
CK1A2	0.489	-0.060	-3	0.191
CK1D	0.489	-0.053	-3	0.195
MSK1	0.489	-0.062	-3	0.383
IKKA	0.488	-0.145	-2	0.521
IRAK1	0.487	-0.172	-1	0.443
CAMK2B	0.486	-0.126	2	0.422
PKG1	0.486	-0.013	-2	0.509
TTBK1	0.483	-0.131	2	0.424
CK2A2	0.483	-0.087	1	0.065
SNRK	0.483	-0.127	2	0.370
GRK4	0.481	-0.214	-2	0.626
AURA	0.480	-0.064	-2	0.452
ALPHAK3	0.480	-0.120	-1	0.479
PLK3	0.480	-0.169	2	0.408
MAPKAPK5	0.479	-0.113	-3	0.355
FAM20C	0.479	-0.064	2	0.324
CK1G1	0.475	-0.071	-3	0.196
RIPK2	0.474	-0.198	1	0.089
CK2A1	0.473	-0.096	1	0.057
STLK3	0.473	-0.166	1	0.092
GRK3	0.472	-0.118	-2	0.523
LIMK2_TYR	0.469	0.274	-3	0.525
YANK3	0.464	-0.076	2	0.191
PKMYT1_TYR	0.458	0.176	3	0.311
TNNI3K_TYR	0.456	0.114	1	0.166
PLK2	0.455	-0.161	-3	0.319
PDHK3_TYR	0.453	0.094	4	0.566
TESK1_TYR	0.452	0.145	3	0.362
LIMK1_TYR	0.450	0.149	2	0.598
YANK2	0.449	-0.082	2	0.205
CK1G3	0.442	-0.099	-3	0.098
PINK1_TYR	0.440	-0.007	1	0.164
TNK1	0.439	0.017	3	0.288
JAK1	0.439	-0.033	1	0.112
CK1A	0.439	-0.091	-3	0.131
MAP2K7_TYR	0.438	-0.072	2	0.546
EPHA6	0.435	-0.049	-1	0.499
ROS1	0.434	-0.070	3	0.303
MAP2K4_TYR	0.434	-0.102	-1	0.535
WEE1_TYR	0.433	0.029	-1	0.419
JAK2	0.433	-0.116	1	0.143
NEK10_TYR	0.432	-0.030	1	0.110
TYK2	0.431	-0.133	1	0.120
TNK2	0.430	-0.075	3	0.264
MAP2K6_TYR	0.430	-0.092	-1	0.541
BMPR2_TYR	0.430	-0.077	-1	0.535
RET	0.429	-0.130	1	0.134
MST1R	0.429	-0.113	3	0.288
CK1G2	0.428	-0.100	-3	0.146
PDHK4_TYR	0.428	-0.120	2	0.520
TYRO3	0.428	-0.089	3	0.327
KDR	0.426	-0.081	3	0.263
PDHK1_TYR	0.426	-0.153	-1	0.562
DDR1	0.426	-0.085	4	0.461
CSF1R	0.424	-0.122	3	0.283
JAK3	0.420	-0.125	1	0.126
ABL2	0.420	-0.135	-1	0.461
ABL1	0.417	-0.136	-1	0.459
LCK	0.417	-0.115	-1	0.492
FGFR1	0.416	-0.105	3	0.265
BLK	0.416	-0.112	-1	0.504
DDR2	0.416	-0.061	3	0.254
TEK	0.416	-0.074	3	0.288
YES1	0.415	-0.140	-1	0.510
EPHB4	0.415	-0.177	-1	0.444
FGFR2	0.414	-0.125	3	0.260
PDGFRB	0.414	-0.166	3	0.306
FGR	0.413	-0.182	1	0.088
FLT3	0.413	-0.160	3	0.315
HCK	0.413	-0.166	-1	0.474
TXK	0.412	-0.131	1	0.075
PDGFRA	0.410	-0.160	3	0.322
KIT	0.410	-0.165	3	0.283
ITK	0.410	-0.156	-1	0.423
MET	0.408	-0.156	3	0.270
AXL	0.408	-0.179	3	0.257
INSRR	0.408	-0.182	3	0.264
ALK	0.407	-0.162	3	0.255
MATK	0.407	-0.087	-1	0.441
MUSK	0.404	-0.087	1	0.061
MERTK	0.403	-0.193	3	0.252
EPHA4	0.402	-0.164	2	0.412
LTK	0.401	-0.173	3	0.252
TEC	0.401	-0.154	-1	0.373
BMX	0.401	-0.145	-1	0.369
FLT1	0.401	-0.166	-1	0.467
EPHB1	0.401	-0.233	1	0.078
FER	0.400	-0.259	1	0.095
FGFR3	0.400	-0.150	3	0.255
FRK	0.399	-0.179	-1	0.482
EPHA1	0.399	-0.183	3	0.264
FYN	0.399	-0.157	-1	0.478
SRMS	0.398	-0.248	1	0.071
EPHB3	0.398	-0.231	-1	0.420
INSR	0.397	-0.184	3	0.252
FLT4	0.397	-0.189	3	0.246
EPHA7	0.396	-0.181	2	0.429
BTK	0.396	-0.213	-1	0.383
ERBB2	0.396	-0.197	1	0.102
EPHB2	0.395	-0.228	-1	0.425
PTK2B	0.394	-0.154	-1	0.439
EGFR	0.393	-0.146	1	0.081
SRC	0.393	-0.171	-1	0.481
CSK	0.393	-0.173	2	0.439
NTRK2	0.393	-0.231	3	0.244
LYN	0.392	-0.202	3	0.237
PTK6	0.392	-0.220	-1	0.369
NTRK3	0.391	-0.198	-1	0.378
EPHA3	0.388	-0.205	2	0.391
FGFR4	0.385	-0.170	-1	0.420
ZAP70	0.384	-0.106	-1	0.396
NTRK1	0.384	-0.289	-1	0.414
ERBB4	0.384	-0.138	1	0.076
EPHA8	0.384	-0.192	-1	0.427
PTK2	0.381	-0.138	-1	0.443
IGF1R	0.379	-0.191	3	0.218
SYK	0.378	-0.165	-1	0.429
EPHA5	0.375	-0.237	2	0.377
EPHA2	0.373	-0.205	-1	0.382
FES	0.369	-0.188	-1	0.359