Motif 696 (n=247)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NEL2 | SOWAHB | S761 | ochoa | Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) | None |
| A8MSY1 | STIMATE-MUSTN1 | S268 | ochoa | Musculoskeletal embryonic nuclear protein 1 | None |
| B8ZZF3 | None | S389 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
| H0YHG0 | None | S475 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| H0YHG0 | None | S478 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| I3L4J1 | None | S119 | ochoa | vesicle-fusing ATPase (EC 3.6.4.6) | (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000256|ARBA:ARBA00059988}. |
| O00203 | AP3B1 | S276 | ochoa | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000305|PubMed:9151686}. |
| O00203 | AP3B1 | S750 | ochoa | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000305|PubMed:9151686}. |
| O00567 | NOP56 | S467 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O00567 | NOP56 | S570 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14917 | PCDH17 | Y747 | ochoa | Protocadherin-17 (Protocadherin-68) | Potential calcium-dependent cell-adhesion protein. |
| O14974 | PPP1R12A | S20 | psp | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O15164 | TRIM24 | S1025 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15318 | POLR3G | S157 | ochoa | DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III subunit G) (RNA polymerase III 32 kDa apha subunit) (RPC32-alpha) (RNA polymerase III 32 kDa subunit) (RPC32) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:20154270, PubMed:20413673, PubMed:35637192). Acts as a long tether that bridges POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer and the mobile stalk of Pol III, coordinating the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state. Pol III exists as two alternative complexes defined by the mutually exclusive incorporation of subunit POLR3G/RPC7alpha or POLR3GL/RPC7beta. POLR3G/RPC7alpha modulates Pol III transcriptome by specifically enhancing the transcription of snaR-A non-coding RNAs. At resting state, occupies the active site of apo Pol III and keeps Pol III in an autoinhibitory mode, preventing non-specific transcription (PubMed:33558764, PubMed:33558766, PubMed:35637192). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20154270, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:34675218, ECO:0000269|PubMed:35637192}. |
| O15355 | PPM1G | S527 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15381 | NVL | S207 | ochoa | Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) | Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}. |
| O15381 | NVL | S211 | ochoa | Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) | Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}. |
| O43290 | SART1 | S762 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O60524 | NEMF | S831 | ochoa | Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) | Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:25578875, PubMed:32726578, PubMed:33406423, PubMed:33909987). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:25578875, PubMed:33406423, PubMed:33909987). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (PubMed:25578875). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423, PubMed:33909987). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (PubMed:33406423, PubMed:33909987). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (PubMed:33909987). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (PubMed:33909987). NEMF may also indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000250|UniProtKB:Q12532, ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33406423, ECO:0000269|PubMed:33909987}. |
| O60841 | EIF5B | S137 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O60841 | EIF5B | S190 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O60841 | EIF5B | S767 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75128 | COBL | S234 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75151 | PHF2 | S882 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75351 | VPS4B | S102 | ochoa | Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) | Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission (PubMed:18687924). Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:18687924, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:16193069, ECO:0000269|PubMed:18606141}. |
| O75475 | PSIP1 | S206 | ochoa|psp | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75475 | PSIP1 | S273 | ochoa|psp | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75569 | PRKRA | S167 | ochoa | Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator) | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250, ECO:0000269|PubMed:10336432, ECO:0000269|PubMed:11238927, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:16982605, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:9687506}. |
| O75914 | PAK3 | S50 | psp | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| O76080 | ZFAND5 | S137 | ochoa | AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}. |
| O94874 | UFL1 | S458 | ochoa | E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1) | E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498, PubMed:27351204, PubMed:30626644, PubMed:30783677, PubMed:32160526, PubMed:32807901, PubMed:35394863, PubMed:36121123, PubMed:36543799, PubMed:36893266, PubMed:37036982, PubMed:37311461, PubMed:37595036, PubMed:37795761, PubMed:38377992, PubMed:38383785, PubMed:38383789). Catalyzes ufmylation of many protein, such as CD274/PD-L1, CDK5RAP3, CYB5R3, DDRGK1, EIF6, histone H4, MRE11, P4HB, PDCD1/PD-1, TRIP4, RPN1, RPS20/uS10, RPL10/uL16, RPL26/uL24, SYVN1/HRD1 and TP53/p53 (PubMed:20018847, PubMed:20531390, PubMed:25219498, PubMed:30783677, PubMed:30886146, PubMed:32160526, PubMed:35753586, PubMed:36543799, PubMed:36893266, PubMed:37036982, PubMed:37595036, PubMed:37795761, PubMed:38383785, PubMed:38383789). As part of the UREL complex, plays a key role in ribosome recycling by catalyzing mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome (PubMed:38383785, PubMed:38383789). Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (PubMed:38383785, PubMed:38383789). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (PubMed:37036982, PubMed:37595036, PubMed:38383785, PubMed:38383789). Involved in reticulophagy in response to endoplasmic reticulum stress by mediating ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (PubMed:23152784, PubMed:32160526, PubMed:36543799). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:32050156). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is, a collateral effect or is required for ufmylation (PubMed:20018847, PubMed:20531390). Acts as a negative regulator of T-cell activation by mediating ufmylation and stabilization of PDCD1/PD-1 (PubMed:38377992). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 and ufmylation of MRE11 (PubMed:30783677, PubMed:30886146). Mediates ufmylation of TP53/p53, promoting its stability (PubMed:32807901). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (PubMed:25219498). Required for hematopoietic stem cell function and hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CCJ3, ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:20531390, ECO:0000269|PubMed:23152784, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:27351204, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:30783677, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:32050156, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:32807901, ECO:0000269|PubMed:35394863, ECO:0000269|PubMed:35753586, ECO:0000269|PubMed:36121123, ECO:0000269|PubMed:36543799, ECO:0000269|PubMed:36893266, ECO:0000269|PubMed:37036982, ECO:0000269|PubMed:37311461, ECO:0000269|PubMed:37595036, ECO:0000269|PubMed:37795761, ECO:0000269|PubMed:38377992, ECO:0000269|PubMed:38383785, ECO:0000269|PubMed:38383789}. |
| O94885 | SASH1 | S135 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95218 | ZRANB2 | S120 | ochoa | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| O95402 | MED26 | S381 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| P07900 | HSP90AA1 | S263 | ochoa|psp | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08047 | SP1 | S698 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08238 | HSP90AB1 | S255 | ochoa|psp | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P09429 | HMGB1 | S42 | ochoa|psp | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P09429 | HMGB1 | S46 | psp | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P0CG47 | UBB | S20 | ochoa | Polyubiquitin-B [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}. |
| P0CG48 | UBC | S20 | ochoa | Polyubiquitin-C [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}. |
| P10244 | MYBL2 | S20 | ochoa|psp | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P11388 | TOP2A | S1476 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P12270 | TPR | S1847 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P17480 | UBTF | S546 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P20042 | EIF2S2 | S67 | ochoa|psp | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| P23528 | CFL1 | S113 | ochoa | Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform) | Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). {ECO:0000250|UniProtKB:P18760, ECO:0000269|PubMed:11812157, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677}. |
| P25685 | DNAJB1 | S171 | ochoa|psp | DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) | Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}. |
| P29374 | ARID4A | S840 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P30260 | CDC27 | S384 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P30414 | NKTR | S416 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P35611 | ADD1 | S707 | psp | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P35659 | DEK | S227 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P35659 | DEK | S251 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P35659 | DEK | S301 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P35659 | DEK | S303 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P41220 | RGS2 | S46 | psp | Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320). {ECO:0000250|UniProtKB:O08849, ECO:0000269|PubMed:11063746, ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199, ECO:0000269|PubMed:19736320, ECO:0000269|PubMed:28784619, ECO:0000305|PubMed:7643615}. |
| P42568 | MLLT3 | S311 | ochoa | Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than conferring, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619, ECO:0000269|PubMed:30374167, ECO:0000269|PubMed:30385749, ECO:0000269|PubMed:31776511}. |
| P45973 | CBX5 | S92 | ochoa|psp | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385}. |
| P46100 | ATRX | S677 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S704 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S1155 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S1156 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S1348 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S2280 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48751 | SLC4A3 | S297 | ochoa | Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:29167417, PubMed:7923606). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417). {ECO:0000269|PubMed:29167417, ECO:0000269|PubMed:7923606}. |
| P49792 | RANBP2 | S2605 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50579 | METAP2 | S29 | ochoa | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
| P53814 | SMTN | S734 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P55036 | PSMD4 | S358 | ochoa | 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}. |
| P55197 | MLLT10 | S217 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P55197 | MLLT10 | S219 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P55197 | MLLT10 | S456 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P62979 | RPS27A | S20 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P62987 | UBA52 | S20 | ochoa | Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}. |
| P82979 | SARNP | S162 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| P82979 | SARNP | S165 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| P83916 | CBX1 | S89 | ochoa | Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000250|UniProtKB:P83917}. |
| Q00013 | MPP1 | S237 | ochoa | 55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) | Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}. |
| Q00059 | TFAM | S128 | ochoa | Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2) | Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172). Is able to unwind DNA (PubMed:22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed:19304746, PubMed:22841477). May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171). {ECO:0000269|PubMed:1737790, ECO:0000269|PubMed:19304746, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:22037171, ECO:0000269|PubMed:22037172, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:29445193, ECO:0000269|PubMed:32183942}. |
| Q01105 | SET | S161 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q01831 | XPC | S61 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q01831 | XPC | S94 | ochoa|psp | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q02952 | AKAP12 | S803 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S1498 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03701 | CEBPZ | S149 | ochoa | CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) | Stimulates transcription from the HSP70 promoter. |
| Q07021 | C1QBP | S87 | ochoa | Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) | Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing (PubMed:10022843, PubMed:10479529, PubMed:10722602, PubMed:11086025, PubMed:11859136, PubMed:15243141, PubMed:16140380, PubMed:16177118, PubMed:17881511, PubMed:18676636, PubMed:19004836, PubMed:19164550, PubMed:20810993, PubMed:21536856, PubMed:21544310, PubMed:22700724, PubMed:28942965, PubMed:8662673, PubMed:8710908, PubMed:9461517). At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades (PubMed:10479529, PubMed:11859136, PubMed:8662673, PubMed:8710908). Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93 (PubMed:20810993, PubMed:8195709). In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK (PubMed:21544310). Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading (PubMed:16140380, PubMed:22700724, PubMed:9461517). Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway (PubMed:16177118). Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity (By similarity). Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (PubMed:39019044). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (PubMed:10022843, PubMed:21536856). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF (PubMed:17486078). May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription (PubMed:15243141, PubMed:18676636). May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase (PubMed:19004836). May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells (PubMed:11086025, PubMed:17881511). Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (PubMed:19164550). Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (PubMed:31353207). {ECO:0000250|UniProtKB:O35658, ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:28942965, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:39019044, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269|PubMed:12034482}. |
| Q08945 | SSRP1 | S510 | psp | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q08945 | SSRP1 | S668 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q09472 | EP300 | S1033 | ochoa | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q09666 | AHNAK | S3362 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12802 | AKAP13 | S1750 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12873 | CHD3 | S597 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q12923 | PTPN13 | S1627 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13017 | ARHGAP5 | S1176 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13144 | EIF2B5 | S466 | psp | Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
| Q13177 | PAK2 | S209 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13185 | CBX3 | S95 | ochoa | Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}. |
| Q13206 | DDX10 | S807 | ochoa | Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) | Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599). {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:36779599}. |
| Q13206 | DDX10 | S809 | ochoa | Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) | Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599). {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:36779599}. |
| Q13427 | PPIG | S696 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13435 | SF3B2 | S319 | ochoa | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| Q13435 | SF3B2 | S861 | ochoa | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| Q13523 | PRP4K | S32 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q14004 | CDK13 | S525 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14320 | FAM50A | S63 | ochoa | Protein FAM50A (Protein HXC-26) (Protein XAP-5) | Probably involved in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:32703943}. |
| Q14498 | RBM39 | S23 | ochoa | RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) | RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}. |
| Q14527 | HLTF | S400 | ochoa | Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. {ECO:0000250, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:18316726, ECO:0000269|PubMed:18719106, ECO:0000269|PubMed:7876228, ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}. |
| Q14568 | HSP90AA2P | S263 | ochoa | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q14677 | CLINT1 | S205 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14684 | RRP1B | S392 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14690 | PDCD11 | S1476 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q14839 | CHD4 | S103 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
| Q14839 | CHD4 | S105 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
| Q15054 | POLD3 | S307 | ochoa | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888, ECO:0000269|PubMed:38099988}. |
| Q15287 | RNPS1 | S27 | ochoa | RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2) | Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions. {ECO:0000269|PubMed:10449421, ECO:0000269|PubMed:11546874, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:14729963, ECO:0000269|PubMed:14752011, ECO:0000269|PubMed:15684395, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:17586820, ECO:0000269|PubMed:22203037}. |
| Q15326 | ZMYND11 | S138 | ochoa | Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69) | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250|UniProtKB:Q8R5C8, ECO:0000269|PubMed:10734313, ECO:0000269|PubMed:16565076, ECO:0000269|PubMed:24675531}.; FUNCTION: (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. {ECO:0000269|PubMed:26845565}. |
| Q15397 | PUM3 | S103 | ochoa | Pumilio homolog 3 (HBV X-transactivated gene 5 protein) (HBV XAg-transactivated protein 5) (Minor histocompatibility antigen HA-8) (HLA-HA8) | Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity). {ECO:0000250|UniProtKB:X1WGX5, ECO:0000269|PubMed:21266351, ECO:0000269|PubMed:25512524}. |
| Q15424 | SAFB | S507 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15464 | SHB | S247 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q17RS7 | GEN1 | S801 | ochoa | Flap endonuclease GEN homolog 1 (EC 3.1.-.-) | Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation (PubMed:19020614, PubMed:26682650). Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction (PubMed:26578604). Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA (PubMed:28049850). Also has endonuclease activity on 5'-flap and replication fork (RF) DNA substrates (PubMed:26578604). {ECO:0000269|PubMed:19020614, ECO:0000269|PubMed:26578604, ECO:0000269|PubMed:26682650, ECO:0000269|PubMed:28049850}. |
| Q2M2Z5 | KIZ | S620 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Q3B726 | POLR1F | S297 | ochoa | DNA-directed RNA polymerase I subunit RPA43 (DNA-directed RNA polymerase I subunit F) (Twist neighbor protein) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}. |
| Q4G0J3 | LARP7 | S261 | ochoa | La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) | RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}. |
| Q53F19 | NCBP3 | S575 | ochoa | Nuclear cap-binding protein subunit 3 (Protein ELG) | Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}. |
| Q53QZ3 | ARHGAP15 | S243 | ochoa | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
| Q562F6 | SGO2 | S1187 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q56P03 | EAPP | S111 | ochoa | E2F-associated phosphoprotein (EAPP) | May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. {ECO:0000269|PubMed:15716352}. |
| Q58FF8 | HSP90AB2P | S177 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FG0 | HSP90AA5P | S89 | ochoa | Putative heat shock protein HSP 90-alpha A5 (Heat shock protein 90-alpha E) (Heat shock protein 90Ae) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5BJF6 | ODF2 | S106 | ochoa | Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) | Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269|PubMed:16966375}. |
| Q5BKY9 | FAM133B | S82 | ochoa | Protein FAM133B | None |
| Q5BKY9 | FAM133B | S148 | ochoa | Protein FAM133B | None |
| Q5BKY9 | FAM133B | S196 | ochoa | Protein FAM133B | None |
| Q5T0W9 | FAM83B | S804 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T200 | ZC3H13 | S1014 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T5C0 | STXBP5 | S1133 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
| Q5UIP0 | RIF1 | S1554 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VTB9 | RNF220 | S199 | ochoa | E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220) | E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658, PubMed:33964137). Plays a critical role in the regulation of nuclear lamina (PubMed:33964137). {ECO:0000250|UniProtKB:Q6PDX6, ECO:0000269|PubMed:25266658, ECO:0000269|PubMed:33964137}. |
| Q5VTL8 | PRPF38B | S471 | ochoa | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | May be required for pre-mRNA splicing. {ECO:0000305}. |
| Q5VTL8 | PRPF38B | S473 | ochoa | Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27) | May be required for pre-mRNA splicing. {ECO:0000305}. |
| Q5VUA4 | ZNF318 | S993 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VZL5 | ZMYM4 | S122 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q6KC79 | NIPBL | S1096 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P0N0 | MIS18BP1 | S634 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P4F7 | ARHGAP11A | S719 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6P4R8 | NFRKB | S298 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6PD62 | CTR9 | S970 | ochoa | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q6RI45 | BRWD3 | S1579 | ochoa | Bromodomain and WD repeat-containing protein 3 | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}. |
| Q6SJ93 | FAM111B | T290 | ochoa | Serine protease FAM111B (EC 3.4.21.-) (Cancer-associated nucleoprotein) | Serine protease. {ECO:0000250|UniProtKB:Q96PZ2}. |
| Q6UB98 | ANKRD12 | S1141 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UB99 | ANKRD11 | S73 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UN15 | FIP1L1 | S554 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6ZMT4 | KDM7A | S604 | ochoa | Lysine-specific demethylase 7A (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) (EC 1.14.11.65) | Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (PubMed:20023638, PubMed:20622853). Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3 (PubMed:20023638). Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (PubMed:20622853). {ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20622853}. |
| Q6ZNL6 | FGD5 | S635 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q71F23 | CENPU | S139 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7Z4V5 | HDGFL2 | S454 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z699 | SPRED1 | S308 | ochoa | Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1) | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S8, ECO:0000269|PubMed:18216281}. |
| Q7Z7L1 | SLFN11 | S142 | ochoa | Schlafen family member 11 (EC 3.1.-.-) | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}. |
| Q86TL2 | STIMATE | S268 | ochoa | Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110) | Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574). {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}. |
| Q86UE4 | MTDH | S562 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86UE4 | MTDH | T564 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86VM9 | ZC3H18 | S173 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q8N1G1 | REXO1 | S499 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N302 | AGGF1 | S306 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N488 | RYBP | S99 | ochoa | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}. |
| Q8N4X5 | AFAP1L2 | S223 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N5G2 | MACO1 | S244 | ochoa | Macoilin (Macoilin-1) (Transmembrane protein 57) | Plays a role in the regulation of neuronal activity. {ECO:0000269|PubMed:21589894}. |
| Q8N6N3 | C1orf52 | S158 | ochoa | UPF0690 protein C1orf52 (BCL10-associated gene protein) | None |
| Q8N9E0 | FAM133A | S149 | ochoa | Protein FAM133A | None |
| Q8N9T8 | KRI1 | S95 | ochoa | Protein KRI1 homolog | None |
| Q8NB78 | KDM1B | S20 | ochoa | Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B) | Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:30970244). {ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23357850, ECO:0000269|PubMed:30970244}. |
| Q8NE71 | ABCF1 | S166 | ochoa | ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) | Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269|PubMed:19570978}. |
| Q8NEF9 | SRFBP1 | S215 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8NFC6 | BOD1L1 | S902 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFQ8 | TOR1AIP2 | S72 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8TAQ2 | SMARCC2 | S286 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TD26 | CHD6 | S185 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8TDI0 | CHD5 | S558 | ochoa | Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.-) (ATP-dependent helicase CHD5) | ATP-dependent chromatin-remodeling factor that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. {ECO:0000250|UniProtKB:A2A8L1, ECO:0000269|PubMed:23948251}. |
| Q8WUA2 | PPIL4 | S471 | ochoa | Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}. |
| Q8WVC0 | LEO1 | S637 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q8WWQ0 | PHIP | S1651 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WYH8 | ING5 | S118 | ochoa | Inhibitor of growth protein 5 (p28ING5) | Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). {ECO:0000269|PubMed:12750254, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21750715, ECO:0000269|PubMed:24065767}. |
| Q92614 | MYO18A | S1528 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92794 | KAT6A | S1136 | ochoa | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
| Q92887 | ABCC2 | S283 | ochoa | ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Also mediates hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505). {ECO:0000269|PubMed:10220572, ECO:0000269|PubMed:10421658, ECO:0000269|PubMed:11500505, ECO:0000269|PubMed:12441801, ECO:0000269|PubMed:16332456}. |
| Q969I6 | SLC38A4 | S49 | ochoa | Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3) | Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:11342143, PubMed:19015196, PubMed:33928121). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11414754). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (PubMed:11414754, PubMed:33928121). {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:19015196, ECO:0000269|PubMed:33928121}. |
| Q96HH9 | GRAMD2B | S26 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96HR8 | NAF1 | S315 | ochoa | H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1) | RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}. |
| Q96PU4 | UHRF2 | S643 | ochoa | E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2) | E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:23404503, PubMed:27743347, PubMed:29506131). Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:24813944, PubMed:27129234). This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639). Also ubiquitinates PCNP leading to its degradation by the proteasome (PubMed:12176013, PubMed:14741369). Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation (PubMed:29923055). Also promotes DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751). Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395). {ECO:0000250|UniProtKB:Q7TMI3, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:14741369, ECO:0000269|PubMed:15178429, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:23404503, ECO:0000269|PubMed:24813944, ECO:0000269|PubMed:27129234, ECO:0000269|PubMed:27743347, ECO:0000269|PubMed:29506131, ECO:0000269|PubMed:29923055, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:33848395}. |
| Q96RS0 | TGS1 | S412 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q96T21 | SECISBP2 | S370 | ochoa | Selenocysteine insertion sequence-binding protein 2 (SECIS-binding protein 2) | mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine (PubMed:35709277). Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling (PubMed:35709277). (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation (PubMed:35709277). (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur (PubMed:35709277). {ECO:0000269|PubMed:35709277}. |
| Q96T23 | RSF1 | S392 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T58 | SPEN | S1485 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99549 | MPHOSPH8 | S188 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99569 | PKP4 | S778 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99575 | POP1 | S371 | ochoa | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| Q9BQG0 | MYBBP1A | S1166 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BRP8 | PYM1 | S139 | ochoa | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}. |
| Q9BU76 | MMTAG2 | S177 | ochoa | Multiple myeloma tumor-associated protein 2 (hMMTAG2) | None |
| Q9BW71 | HIRIP3 | S223 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BXS6 | NUSAP1 | S365 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9BYW2 | SETD2 | S1413 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZ95 | NSD3 | S585 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9BZ95 | NSD3 | S587 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9BZG1 | RAB34 | S241 | ochoa | Ras-related protein Rab-34 (EC 3.6.5.2) (Ras-related protein Rab-39) (Ras-related protein Rah) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB34 transports protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:27113757). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Involved in ciliogenesis (PubMed:37384395). In particular, it is required for early steps of the intracellular cilium assembly pathway initiated by trafficking and docking of ciliary vesicles to the centrioles in the cytoplasm, followed by axoneme formation in the cytoplasm. After axoneme elongation, the centrioles migrate close to the cell surface so that ciliary vesicles can fuse with the plasma membrane to expose cilia to the extracellular space (By similarity). It seems dispensable for ciliogenesis via the extracellular pathway where cilium assembly begins after migration and docking of the centriole to the plasma membrane (By similarity). Also acts as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity). {ECO:0000250|UniProtKB:P20340, ECO:0000250|UniProtKB:Q64008, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:37384395}. |
| Q9C0B9 | ZCCHC2 | S564 | ochoa | Zinc finger CCHC domain-containing protein 2 | None |
| Q9H2G2 | SLK | S777 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2P0 | ADNP | S1001 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H501 | ESF1 | S82 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H8M2 | BRD9 | S56 | ochoa | Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) | Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). {ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:32457312}. |
| Q9HAW4 | CLSPN | S232 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HB21 | PLEKHA1 | S125 | ochoa | Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}. |
| Q9NPG3 | UBN1 | S173 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NR30 | DDX21 | S121 | ochoa|psp | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NRZ9 | HELLS | S115 | ochoa | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Q9NRZ9 | HELLS | S164 | ochoa | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Q9P0K1 | ADAM22 | S832 | ochoa | Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269|PubMed:12589811, ECO:0000269|PubMed:15882968, ECO:0000269|PubMed:16385342, ECO:0000269|PubMed:19692335}. |
| Q9P246 | STIM2 | S719 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P2E9 | RRBP1 | S615 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9P2R6 | RERE | S656 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
| Q9P2X3 | IMPACT | S297 | ochoa | Protein IMPACT (Imprinted and ancient gene protein homolog) | Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. {ECO:0000250|UniProtKB:O55091}. |
| Q9ULH0 | KIDINS220 | S1531 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULU4 | ZMYND8 | S676 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UN37 | VPS4A | S95 | ochoa | Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) | Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization, chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (PubMed:33186545). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Critical for normal erythroblast cytokinesis and correct erythropoiesis (PubMed:33186543). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:15075231, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:33186543, ECO:0000269|PubMed:33186545}.; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:11595185}. |
| Q9UNF1 | MAGED2 | S162 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UNL4 | ING4 | S119 | ochoa | Inhibitor of growth protein 4 (p29ING4) | Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). {ECO:0000250|UniProtKB:Q8C0D7, ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:15251430, ECO:0000269|PubMed:15528276, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:16387653}. |
| Q9UNL4 | ING4 | S125 | ochoa | Inhibitor of growth protein 4 (p29ING4) | Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). {ECO:0000250|UniProtKB:Q8C0D7, ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:15251430, ECO:0000269|PubMed:15528276, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:16387653}. |
| Q9UNL4 | ING4 | S150 | ochoa | Inhibitor of growth protein 4 (p29ING4) | Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). {ECO:0000250|UniProtKB:Q8C0D7, ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:15251430, ECO:0000269|PubMed:15528276, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:16387653}. |
| Q9UPP1 | PHF8 | S857 | ochoa|psp | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9UQ35 | SRRM2 | S177 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S178 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y281 | CFL2 | S113 | ochoa | Cofilin-2 (Cofilin, muscle isoform) | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). {ECO:0000250|UniProtKB:P45591, ECO:0000269|PubMed:19752190}. |
| Q9Y383 | LUC7L2 | S354 | ochoa | Putative RNA-binding protein Luc7-like 2 | May bind to RNA via its Arg/Ser-rich domain. |
| Q9Y5T5 | USP16 | S330 | psp | Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability. {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:17914355, ECO:0000269|PubMed:32129764}. |
| P27695 | APEX1 | S66 | Sugiyama | DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] | Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors (PubMed:11118054, PubMed:11452037, PubMed:15831793, PubMed:18439621, PubMed:18579163, PubMed:21762700, PubMed:24079850, PubMed:8355688, PubMed:9108029, PubMed:9560228). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules (PubMed:15380100, PubMed:16617147, PubMed:18439621, PubMed:19123919, PubMed:19188445, PubMed:19934257, PubMed:20699270, PubMed:21762700, PubMed:24079850, PubMed:8932375, PubMed:8995436, PubMed:9804799). Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG. Generates staggered nicks in opposite DNA strands resulting in the formation of double-strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (By similarity). Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:11832948, PubMed:1719477). Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate and 8-oxoguanine) blocking the 3' side of DNA strand breaks (PubMed:15831793, PubMed:7516064). Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression (PubMed:19188445, PubMed:19401441, PubMed:21762700). Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB (PubMed:9207062). Exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR (PubMed:10023679, PubMed:11118054, PubMed:11452037, PubMed:18579163, PubMed:8355688, PubMed:9108029). Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (PubMed:11809897, PubMed:14633989, PubMed:8621488). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance (PubMed:18809583). Plays a role in protection from granzyme-mediated cellular repair leading to cell death (PubMed:18179823). Binds DNA and RNA. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA (PubMed:19188445, PubMed:19401441, PubMed:20699270). {ECO:0000250|UniProtKB:P28352, ECO:0000269|PubMed:10023679, ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:11452037, ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:11832948, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:14633989, ECO:0000269|PubMed:15380100, ECO:0000269|PubMed:15831793, ECO:0000269|PubMed:16617147, ECO:0000269|PubMed:1719477, ECO:0000269|PubMed:18179823, ECO:0000269|PubMed:18439621, ECO:0000269|PubMed:18579163, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19123919, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:19401441, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20699270, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21762700, ECO:0000269|PubMed:24079850, ECO:0000269|PubMed:7516064, ECO:0000269|PubMed:8355688, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:8932375, ECO:0000269|PubMed:8995436, ECO:0000269|PubMed:9108029, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9560228, ECO:0000269|PubMed:9804799}. |
| Q9Y3B8 | REXO2 | S203 | Sugiyama | Oligoribonuclease, mitochondrial (EC 3.1.15.-) (RNA exonuclease 2 homolog) (Small fragment nuclease) | 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:23741365, PubMed:30926754, PubMed:31588022, PubMed:32365187). Binds and degrades longer oligonucleotides with a lower affinity (PubMed:30926754, PubMed:31588022, PubMed:32365187). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:30926754, PubMed:31588022, PubMed:32365187). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:Q9D8S4, ECO:0000269|PubMed:23741365, ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022, ECO:0000269|PubMed:32365187}.; FUNCTION: [Isoform 3]: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. {ECO:0000269|PubMed:10851236, ECO:0000269|PubMed:16682444}. |
| P13667 | PDIA4 | S495 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P61247 | RPS3A | S203 | Sugiyama | Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| O60566 | BUB1B | S411 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q05519 | SRSF11 | Y425 | Sugiyama | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | May function in pre-mRNA splicing. |
| P46778 | RPL21 | S104 | Sugiyama | Large ribosomal subunit protein eL21 (60S ribosomal protein L21) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}. |
| P30040 | ERP29 | S219 | Sugiyama | Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31) | Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER. |
| Q8N5S9 | CAMKK1 | S149 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Q8NG66 | NEK11 | S39 | Sugiyama | Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) | Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}. |
| P20810 | CAST | S45 | SIGNOR | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| O94763 | URI1 | S188 | Sugiyama | Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) | Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 2.310893e-08 | 7.636 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.488147e-08 | 7.457 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.274920e-06 | 5.895 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.567023e-06 | 5.591 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.730758e-06 | 5.564 |
| R-HSA-4839726 | Chromatin organization | 2.302093e-06 | 5.638 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 3.814437e-06 | 5.419 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.216472e-06 | 5.283 |
| R-HSA-9683683 | Maturation of protein E | 6.434518e-06 | 5.191 |
| R-HSA-9694493 | Maturation of protein E | 6.434518e-06 | 5.191 |
| R-HSA-68886 | M Phase | 7.314032e-06 | 5.136 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 9.614896e-06 | 5.017 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 1.372394e-05 | 4.863 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.536024e-05 | 4.814 |
| R-HSA-162588 | Budding and maturation of HIV virion | 1.870491e-05 | 4.728 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 2.223786e-05 | 4.653 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 2.223786e-05 | 4.653 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 2.223786e-05 | 4.653 |
| R-HSA-8953854 | Metabolism of RNA | 1.785651e-05 | 4.748 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 2.223786e-05 | 4.653 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 2.223786e-05 | 4.653 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.917392e-05 | 4.535 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.881548e-05 | 4.540 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.061581e-05 | 4.514 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 3.114393e-05 | 4.507 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.385736e-05 | 4.622 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4.253250e-05 | 4.371 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 4.253250e-05 | 4.371 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 4.241800e-05 | 4.372 |
| R-HSA-5689877 | Josephin domain DUBs | 4.241800e-05 | 4.372 |
| R-HSA-9664873 | Pexophagy | 4.241800e-05 | 4.372 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.868095e-05 | 4.313 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 5.077303e-05 | 4.294 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 5.641822e-05 | 4.249 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 5.641822e-05 | 4.249 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.253804e-05 | 4.204 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 8.304435e-05 | 4.081 |
| R-HSA-3371568 | Attenuation phase | 6.978709e-05 | 4.156 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 7.351991e-05 | 4.134 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 9.411408e-05 | 4.026 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 9.411408e-05 | 4.026 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 9.411408e-05 | 4.026 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 7.351991e-05 | 4.134 |
| R-HSA-209560 | NF-kB is activated and signals survival | 7.351991e-05 | 4.134 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 9.411408e-05 | 4.026 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 9.411408e-05 | 4.026 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 9.411408e-05 | 4.026 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 9.411408e-05 | 4.026 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.120438e-04 | 3.951 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.279887e-04 | 3.893 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.120438e-04 | 3.951 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.474147e-04 | 3.831 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.186062e-04 | 3.926 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.474147e-04 | 3.831 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.474147e-04 | 3.831 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.474147e-04 | 3.831 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.809699e-04 | 3.742 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.809699e-04 | 3.742 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 1.693914e-04 | 3.771 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.544930e-04 | 3.811 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.809699e-04 | 3.742 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.809699e-04 | 3.742 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.809699e-04 | 3.742 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.608227e-04 | 3.794 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.809699e-04 | 3.742 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.809699e-04 | 3.742 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.546734e-04 | 3.811 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.927693e-04 | 3.715 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.197128e-04 | 3.658 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.185293e-04 | 3.660 |
| R-HSA-69275 | G2/M Transition | 2.171774e-04 | 3.663 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.185293e-04 | 3.660 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.197128e-04 | 3.658 |
| R-HSA-9708530 | Regulation of BACH1 activity | 2.197128e-04 | 3.658 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.197128e-04 | 3.658 |
| R-HSA-8852135 | Protein ubiquitination | 2.250116e-04 | 3.648 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.369119e-04 | 3.625 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.357384e-04 | 3.628 |
| R-HSA-162587 | HIV Life Cycle | 2.562482e-04 | 3.591 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.589687e-04 | 3.587 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.640937e-04 | 3.578 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.640937e-04 | 3.578 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.640937e-04 | 3.578 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.640937e-04 | 3.578 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.778309e-04 | 3.556 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.778309e-04 | 3.556 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.826084e-04 | 3.549 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.826084e-04 | 3.549 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.926983e-04 | 3.534 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.349544e-04 | 3.475 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 3.145715e-04 | 3.502 |
| R-HSA-3229121 | Glycogen storage diseases | 3.145715e-04 | 3.502 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.479584e-04 | 3.458 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.486098e-04 | 3.458 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.486098e-04 | 3.458 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.638247e-04 | 3.439 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.638247e-04 | 3.439 |
| R-HSA-169911 | Regulation of Apoptosis | 3.887323e-04 | 3.410 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.887323e-04 | 3.410 |
| R-HSA-110320 | Translesion Synthesis by POLH | 4.356881e-04 | 3.361 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.152043e-04 | 3.382 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.793360e-04 | 3.319 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.152043e-04 | 3.382 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 4.356881e-04 | 3.361 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.322469e-04 | 3.364 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.425070e-04 | 3.354 |
| R-HSA-912631 | Regulation of signaling by CBL | 4.356881e-04 | 3.361 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.418275e-04 | 3.355 |
| R-HSA-6807004 | Negative regulation of MET activity | 5.072769e-04 | 3.295 |
| R-HSA-3322077 | Glycogen synthesis | 5.072769e-04 | 3.295 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.301856e-04 | 3.276 |
| R-HSA-9646399 | Aggrephagy | 6.439275e-04 | 3.191 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.555678e-04 | 3.183 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.555678e-04 | 3.183 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 6.439275e-04 | 3.191 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.802921e-04 | 3.236 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 5.868607e-04 | 3.231 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 6.439275e-04 | 3.191 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.791401e-04 | 3.237 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.802921e-04 | 3.236 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 5.868607e-04 | 3.231 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 5.868607e-04 | 3.231 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 5.868607e-04 | 3.231 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 6.749248e-04 | 3.171 |
| R-HSA-175474 | Assembly Of The HIV Virion | 6.749248e-04 | 3.171 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 6.749248e-04 | 3.171 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 6.749248e-04 | 3.171 |
| R-HSA-68882 | Mitotic Anaphase | 6.964269e-04 | 3.157 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 7.072086e-04 | 3.150 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 7.206186e-04 | 3.142 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 7.719576e-04 | 3.112 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 7.719576e-04 | 3.112 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.824031e-04 | 3.107 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 8.276226e-04 | 3.082 |
| R-HSA-3371556 | Cellular response to heat stress | 8.345407e-04 | 3.079 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 8.475856e-04 | 3.072 |
| R-HSA-5218859 | Regulated Necrosis | 8.855873e-04 | 3.053 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.962969e-04 | 3.048 |
| R-HSA-162909 | Host Interactions of HIV factors | 9.594973e-04 | 3.018 |
| R-HSA-162906 | HIV Infection | 1.003382e-03 | 2.999 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.189342e-03 | 2.925 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.145492e-03 | 2.941 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.078389e-03 | 2.967 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.078389e-03 | 2.967 |
| R-HSA-3214842 | HDMs demethylate histones | 1.121771e-03 | 2.950 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.095755e-03 | 2.960 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.095755e-03 | 2.960 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 1.259585e-03 | 2.900 |
| R-HSA-382556 | ABC-family proteins mediated transport | 1.230937e-03 | 2.910 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 1.259585e-03 | 2.900 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.288714e-03 | 2.890 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.288714e-03 | 2.890 |
| R-HSA-109581 | Apoptosis | 1.309540e-03 | 2.883 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.383726e-03 | 2.859 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1.408820e-03 | 2.851 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 1.408820e-03 | 2.851 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 1.408820e-03 | 2.851 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.469443e-03 | 2.833 |
| R-HSA-5689603 | UCH proteinases | 1.469443e-03 | 2.833 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.503532e-03 | 2.823 |
| R-HSA-73893 | DNA Damage Bypass | 1.505681e-03 | 2.822 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 1.505681e-03 | 2.822 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.551465e-03 | 2.809 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.569964e-03 | 2.804 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.569964e-03 | 2.804 |
| R-HSA-9833110 | RSV-host interactions | 1.578518e-03 | 2.802 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.623713e-03 | 2.789 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.652961e-03 | 2.782 |
| R-HSA-72172 | mRNA Splicing | 1.655906e-03 | 2.781 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.656386e-03 | 2.781 |
| R-HSA-5357801 | Programmed Cell Death | 1.710225e-03 | 2.767 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.743504e-03 | 2.759 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.743504e-03 | 2.759 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 1.743504e-03 | 2.759 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.018643e-03 | 2.695 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.071727e-03 | 2.684 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.908034e-03 | 2.719 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.979084e-03 | 2.704 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.164642e-03 | 2.665 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.129697e-03 | 2.672 |
| R-HSA-182971 | EGFR downregulation | 2.129697e-03 | 2.672 |
| R-HSA-74160 | Gene expression (Transcription) | 2.339149e-03 | 2.631 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 1.879971e-03 | 2.726 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.318191e-03 | 2.635 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.166799e-03 | 2.664 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.821068e-03 | 2.740 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.821068e-03 | 2.740 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.343305e-03 | 2.630 |
| R-HSA-1538133 | G0 and Early G1 | 2.343305e-03 | 2.630 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.402051e-03 | 2.619 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 2.479517e-03 | 2.606 |
| R-HSA-177929 | Signaling by EGFR | 2.479517e-03 | 2.606 |
| R-HSA-5654736 | Signaling by FGFR1 | 2.479517e-03 | 2.606 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.499504e-03 | 2.602 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 2.571216e-03 | 2.590 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.788935e-03 | 2.555 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.813897e-03 | 2.551 |
| R-HSA-6782135 | Dual incision in TC-NER | 2.826398e-03 | 2.549 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.071808e-03 | 2.513 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.071808e-03 | 2.513 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.071808e-03 | 2.513 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.071808e-03 | 2.513 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.071808e-03 | 2.513 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.071808e-03 | 2.513 |
| R-HSA-5205647 | Mitophagy | 3.071808e-03 | 2.513 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.207093e-03 | 2.494 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.207093e-03 | 2.494 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.207093e-03 | 2.494 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.207093e-03 | 2.494 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.207093e-03 | 2.494 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.207093e-03 | 2.494 |
| R-HSA-5693538 | Homology Directed Repair | 3.222992e-03 | 2.492 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.345403e-03 | 2.476 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.345403e-03 | 2.476 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.414904e-03 | 2.467 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.458625e-03 | 2.461 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.581417e-03 | 2.446 |
| R-HSA-3371511 | HSF1 activation | 3.635132e-03 | 2.439 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.635132e-03 | 2.439 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.635132e-03 | 2.439 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.635132e-03 | 2.439 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.639852e-03 | 2.439 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.707562e-03 | 2.431 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.837120e-03 | 2.416 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.845493e-03 | 2.415 |
| R-HSA-373755 | Semaphorin interactions | 3.845493e-03 | 2.415 |
| R-HSA-4641258 | Degradation of DVL | 3.941435e-03 | 2.404 |
| R-HSA-4641257 | Degradation of AXIN | 3.941435e-03 | 2.404 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.941435e-03 | 2.404 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.941435e-03 | 2.404 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.077156e-03 | 2.390 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.318625e-03 | 2.365 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.585133e-03 | 2.339 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.605499e-03 | 2.337 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.605499e-03 | 2.337 |
| R-HSA-69541 | Stabilization of p53 | 4.605499e-03 | 2.337 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.605499e-03 | 2.337 |
| R-HSA-9648002 | RAS processing | 4.605499e-03 | 2.337 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.605499e-03 | 2.337 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.629971e-03 | 2.178 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.424943e-03 | 2.192 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.702985e-03 | 2.244 |
| R-HSA-5688426 | Deubiquitination | 6.901885e-03 | 2.161 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 5.736536e-03 | 2.241 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.629971e-03 | 2.178 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.964107e-03 | 2.304 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.340985e-03 | 2.272 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.340985e-03 | 2.272 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 6.585235e-03 | 2.181 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 7.039148e-03 | 2.152 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.948483e-03 | 2.226 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.010881e-03 | 2.300 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.629971e-03 | 2.178 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.979782e-03 | 2.303 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 5.340985e-03 | 2.272 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.736536e-03 | 2.241 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.736536e-03 | 2.241 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 6.585235e-03 | 2.181 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.736536e-03 | 2.241 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.302107e-03 | 2.201 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.969608e-03 | 2.157 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 7.039148e-03 | 2.152 |
| R-HSA-5654743 | Signaling by FGFR4 | 6.585235e-03 | 2.181 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 6.585235e-03 | 2.181 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.736536e-03 | 2.241 |
| R-HSA-69236 | G1 Phase | 7.039148e-03 | 2.152 |
| R-HSA-69231 | Cyclin D associated events in G1 | 7.039148e-03 | 2.152 |
| R-HSA-8982491 | Glycogen metabolism | 4.964107e-03 | 2.304 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.736536e-03 | 2.241 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 6.151157e-03 | 2.211 |
| R-HSA-9607240 | FLT3 Signaling | 5.340985e-03 | 2.272 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 7.321227e-03 | 2.135 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 7.513266e-03 | 2.124 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 7.513266e-03 | 2.124 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 7.513266e-03 | 2.124 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 7.513266e-03 | 2.124 |
| R-HSA-5654741 | Signaling by FGFR3 | 7.513266e-03 | 2.124 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 7.622823e-03 | 2.118 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.685038e-03 | 2.114 |
| R-HSA-69239 | Synthesis of DNA | 7.887809e-03 | 2.103 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 8.007947e-03 | 2.096 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 8.007947e-03 | 2.096 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 8.007947e-03 | 2.096 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 8.007947e-03 | 2.096 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 8.007947e-03 | 2.096 |
| R-HSA-75153 | Apoptotic execution phase | 8.007947e-03 | 2.096 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 8.197990e-03 | 2.086 |
| R-HSA-168255 | Influenza Infection | 8.368669e-03 | 2.077 |
| R-HSA-5619084 | ABC transporter disorders | 8.450059e-03 | 2.073 |
| R-HSA-202403 | TCR signaling | 8.844512e-03 | 2.053 |
| R-HSA-72731 | Recycling of eIF2:GDP | 9.323059e-03 | 2.030 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 9.323059e-03 | 2.030 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 9.526774e-03 | 2.021 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 9.526774e-03 | 2.021 |
| R-HSA-9679506 | SARS-CoV Infections | 9.558577e-03 | 2.020 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 9.565703e-03 | 2.019 |
| R-HSA-9766229 | Degradation of CDH1 | 9.618841e-03 | 2.017 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 9.618841e-03 | 2.017 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 9.618841e-03 | 2.017 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 9.618841e-03 | 2.017 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 9.694115e-03 | 2.013 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.013533e-02 | 1.994 |
| R-HSA-9839394 | TGFBR3 expression | 1.044535e-02 | 1.981 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.072352e-02 | 1.970 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.080177e-02 | 1.967 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.080177e-02 | 1.967 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.080177e-02 | 1.967 |
| R-HSA-72187 | mRNA 3'-end processing | 1.142687e-02 | 1.942 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.142687e-02 | 1.942 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.142687e-02 | 1.942 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.142687e-02 | 1.942 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.142687e-02 | 1.942 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.154126e-02 | 1.938 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.172392e-02 | 1.931 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.203795e-02 | 1.919 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.203795e-02 | 1.919 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.207478e-02 | 1.918 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.207478e-02 | 1.918 |
| R-HSA-446652 | Interleukin-1 family signaling | 1.207495e-02 | 1.918 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.234125e-02 | 1.909 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.254896e-02 | 1.901 |
| R-HSA-72649 | Translation initiation complex formation | 1.274580e-02 | 1.895 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.317621e-02 | 1.880 |
| R-HSA-68875 | Mitotic Prophase | 1.350946e-02 | 1.869 |
| R-HSA-156902 | Peptide chain elongation | 1.361468e-02 | 1.866 |
| R-HSA-9663891 | Selective autophagy | 1.361468e-02 | 1.866 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.415820e-02 | 1.849 |
| R-HSA-75893 | TNF signaling | 1.415820e-02 | 1.849 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.416972e-02 | 1.849 |
| R-HSA-9711097 | Cellular response to starvation | 1.434238e-02 | 1.843 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.490010e-02 | 1.827 |
| R-HSA-2262752 | Cellular responses to stress | 1.500056e-02 | 1.824 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.516162e-02 | 1.819 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.531993e-02 | 1.815 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.532503e-02 | 1.815 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.566613e-02 | 1.805 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.592562e-02 | 1.798 |
| R-HSA-9033241 | Peroxisomal protein import | 1.645651e-02 | 1.784 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.645651e-02 | 1.784 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.654170e-02 | 1.781 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.717344e-02 | 1.765 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.811121e-02 | 1.742 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.811121e-02 | 1.742 |
| R-HSA-450294 | MAP kinase activation | 1.811121e-02 | 1.742 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.828438e-02 | 1.548 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 2.828438e-02 | 1.548 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.828438e-02 | 1.548 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.828438e-02 | 1.548 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.828438e-02 | 1.548 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.828438e-02 | 1.548 |
| R-HSA-9645722 | Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | 2.828438e-02 | 1.548 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 2.523970e-02 | 1.598 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.523970e-02 | 1.598 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 3.094787e-02 | 1.509 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.711240e-02 | 1.430 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.610964e-02 | 1.583 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.922693e-02 | 1.534 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.085616e-02 | 1.511 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.172189e-02 | 1.663 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.916408e-02 | 1.718 |
| R-HSA-192823 | Viral mRNA Translation | 2.519621e-02 | 1.599 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.952181e-02 | 1.530 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.914384e-02 | 1.718 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.085616e-02 | 1.511 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.711240e-02 | 1.430 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.253224e-02 | 1.488 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.438314e-02 | 1.613 |
| R-HSA-72764 | Eukaryotic Translation Termination | 1.916408e-02 | 1.718 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.085616e-02 | 1.511 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.136057e-02 | 1.504 |
| R-HSA-72312 | rRNA processing | 3.028668e-02 | 1.519 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.438314e-02 | 1.613 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.178812e-02 | 1.662 |
| R-HSA-68877 | Mitotic Prometaphase | 3.460147e-02 | 1.461 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.057210e-02 | 1.687 |
| R-HSA-73894 | DNA Repair | 2.241770e-02 | 1.649 |
| R-HSA-69242 | S Phase | 3.375980e-02 | 1.472 |
| R-HSA-428540 | Activation of RAC1 | 2.001940e-02 | 1.699 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 3.397501e-02 | 1.469 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.232882e-02 | 1.490 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.232882e-02 | 1.490 |
| R-HSA-9909396 | Circadian clock | 2.085772e-02 | 1.681 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.773911e-02 | 1.557 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.043967e-02 | 1.517 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.358718e-02 | 1.627 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.130080e-02 | 1.672 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.137531e-02 | 1.503 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.137531e-02 | 1.503 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.130080e-02 | 1.672 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.130080e-02 | 1.672 |
| R-HSA-6807070 | PTEN Regulation | 2.608577e-02 | 1.584 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.529731e-02 | 1.452 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.523970e-02 | 1.598 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 3.094787e-02 | 1.509 |
| R-HSA-5632684 | Hedgehog 'on' state | 2.791085e-02 | 1.554 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.681392e-02 | 1.572 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.078866e-02 | 1.682 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.681392e-02 | 1.572 |
| R-HSA-2559583 | Cellular Senescence | 2.586454e-02 | 1.587 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.204613e-02 | 1.657 |
| R-HSA-448424 | Interleukin-17 signaling | 2.681392e-02 | 1.572 |
| R-HSA-9824446 | Viral Infection Pathways | 2.506720e-02 | 1.601 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.903421e-02 | 1.537 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.681392e-02 | 1.572 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.043967e-02 | 1.517 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.368067e-02 | 1.626 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.137531e-02 | 1.503 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.172189e-02 | 1.663 |
| R-HSA-190236 | Signaling by FGFR | 2.130080e-02 | 1.672 |
| R-HSA-4086400 | PCP/CE pathway | 3.633376e-02 | 1.440 |
| R-HSA-1236394 | Signaling by ERBB4 | 3.136057e-02 | 1.504 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.379360e-02 | 1.471 |
| R-HSA-917937 | Iron uptake and transport | 3.256372e-02 | 1.487 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 3.018409e-02 | 1.520 |
| R-HSA-9694635 | Translation of Structural Proteins | 3.505027e-02 | 1.455 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.986584e-02 | 1.702 |
| R-HSA-8848021 | Signaling by PTK6 | 1.986584e-02 | 1.702 |
| R-HSA-69306 | DNA Replication | 3.809233e-02 | 1.419 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.842915e-02 | 1.415 |
| R-HSA-5654738 | Signaling by FGFR2 | 3.898135e-02 | 1.409 |
| R-HSA-6806834 | Signaling by MET | 3.898135e-02 | 1.409 |
| R-HSA-977225 | Amyloid fiber formation | 4.034548e-02 | 1.394 |
| R-HSA-9612973 | Autophagy | 4.085473e-02 | 1.389 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.160828e-02 | 1.381 |
| R-HSA-774815 | Nucleosome assembly | 4.160828e-02 | 1.381 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.182677e-02 | 1.379 |
| R-HSA-73930 | Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | 4.212642e-02 | 1.375 |
| R-HSA-163282 | Mitochondrial transcription initiation | 4.212642e-02 | 1.375 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.315448e-02 | 1.365 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.356084e-02 | 1.361 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 4.370312e-02 | 1.359 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 4.370312e-02 | 1.359 |
| R-HSA-156711 | Polo-like kinase mediated events | 4.370312e-02 | 1.359 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 4.370312e-02 | 1.359 |
| R-HSA-3928664 | Ephrin signaling | 4.370312e-02 | 1.359 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.401590e-02 | 1.356 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.401590e-02 | 1.356 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.459932e-02 | 1.351 |
| R-HSA-73886 | Chromosome Maintenance | 4.638003e-02 | 1.334 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.638003e-02 | 1.334 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.756961e-02 | 1.323 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.758995e-02 | 1.322 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.758995e-02 | 1.322 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.828750e-02 | 1.316 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.882917e-02 | 1.311 |
| R-HSA-70268 | Pyruvate metabolism | 5.064716e-02 | 1.295 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.064716e-02 | 1.295 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 5.069123e-02 | 1.295 |
| R-HSA-69481 | G2/M Checkpoints | 5.524060e-02 | 1.258 |
| R-HSA-202424 | Downstream TCR signaling | 5.546372e-02 | 1.256 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 5.577212e-02 | 1.254 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 5.577212e-02 | 1.254 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 5.577212e-02 | 1.254 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 5.577212e-02 | 1.254 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 5.577212e-02 | 1.254 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 5.577212e-02 | 1.254 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 5.577212e-02 | 1.254 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 5.577212e-02 | 1.254 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 5.577212e-02 | 1.254 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 5.577212e-02 | 1.254 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 5.577212e-02 | 1.254 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 5.577212e-02 | 1.254 |
| R-HSA-75944 | Transcription from mitochondrial promoters | 5.577212e-02 | 1.254 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.765397e-02 | 1.239 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 5.804918e-02 | 1.236 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.006133e-02 | 1.221 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.006133e-02 | 1.221 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.006133e-02 | 1.221 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.051893e-02 | 1.218 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.051893e-02 | 1.218 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.077418e-02 | 1.216 |
| R-HSA-72766 | Translation | 6.165152e-02 | 1.210 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 6.185858e-02 | 1.209 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 6.185858e-02 | 1.209 |
| R-HSA-9843745 | Adipogenesis | 6.212871e-02 | 1.207 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.311903e-02 | 1.200 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.604339e-02 | 1.180 |
| R-HSA-422475 | Axon guidance | 6.618643e-02 | 1.179 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 6.922425e-02 | 1.160 |
| R-HSA-5679001 | Defective ABCC2 causes DJS | 6.922425e-02 | 1.160 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.946789e-02 | 1.158 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.271274e-02 | 1.138 |
| R-HSA-191859 | snRNP Assembly | 7.290835e-02 | 1.137 |
| R-HSA-194441 | Metabolism of non-coding RNA | 7.290835e-02 | 1.137 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 7.377055e-02 | 1.132 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 7.377055e-02 | 1.132 |
| R-HSA-3214847 | HATs acetylate histones | 7.514634e-02 | 1.124 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.545572e-02 | 1.122 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.708986e-02 | 1.113 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 7.789235e-02 | 1.109 |
| R-HSA-1632852 | Macroautophagy | 7.891133e-02 | 1.103 |
| R-HSA-6784531 | tRNA processing in the nucleus | 8.066692e-02 | 1.093 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.105204e-02 | 1.091 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 8.208484e-02 | 1.086 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 8.248556e-02 | 1.084 |
| R-HSA-449147 | Signaling by Interleukins | 8.379820e-02 | 1.077 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.511333e-02 | 1.070 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.127173e-02 | 1.040 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.200844e-02 | 1.036 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 9.249675e-02 | 1.034 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.327029e-02 | 1.030 |
| R-HSA-211000 | Gene Silencing by RNA | 9.352763e-02 | 1.029 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 9.505847e-02 | 1.022 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 9.505847e-02 | 1.022 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 9.505847e-02 | 1.022 |
| R-HSA-9008059 | Interleukin-37 signaling | 9.505847e-02 | 1.022 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 9.555873e-02 | 1.020 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 9.555873e-02 | 1.020 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 9.555873e-02 | 1.020 |
| R-HSA-2672351 | Stimuli-sensing channels | 9.569089e-02 | 1.019 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.607009e-02 | 1.017 |
| R-HSA-9675108 | Nervous system development | 9.616378e-02 | 1.017 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 9.719355e-02 | 1.012 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 9.950607e-02 | 1.002 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 9.950607e-02 | 1.002 |
| R-HSA-9609507 | Protein localization | 1.015601e-01 | 0.993 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.029852e-01 | 0.987 |
| R-HSA-73887 | Death Receptor Signaling | 1.034244e-01 | 0.985 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.040109e-01 | 0.983 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.040109e-01 | 0.983 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.046675e-01 | 0.980 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.059315e-01 | 0.975 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.084464e-01 | 0.965 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.085703e-01 | 0.964 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.085703e-01 | 0.964 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.085703e-01 | 0.964 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.131820e-01 | 0.946 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 1.131820e-01 | 0.946 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.131820e-01 | 0.946 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.161918e-01 | 0.935 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.161918e-01 | 0.935 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.178435e-01 | 0.929 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 1.211513e-01 | 0.917 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 1.211513e-01 | 0.917 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 1.211513e-01 | 0.917 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 1.211513e-01 | 0.917 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 1.211513e-01 | 0.917 |
| R-HSA-164944 | Nef and signal transduction | 1.211513e-01 | 0.917 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.225525e-01 | 0.912 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.225525e-01 | 0.912 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.258722e-01 | 0.900 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.268358e-01 | 0.897 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 1.273067e-01 | 0.895 |
| R-HSA-74158 | RNA Polymerase III Transcription | 1.273067e-01 | 0.895 |
| R-HSA-418990 | Adherens junctions interactions | 1.297435e-01 | 0.887 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 1.308367e-01 | 0.883 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.336758e-01 | 0.874 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.336758e-01 | 0.874 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.338551e-01 | 0.873 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.369418e-01 | 0.863 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.371030e-01 | 0.863 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.418184e-01 | 0.848 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.418184e-01 | 0.848 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 1.418184e-01 | 0.848 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.419456e-01 | 0.848 |
| R-HSA-194138 | Signaling by VEGF | 1.435938e-01 | 0.843 |
| R-HSA-69206 | G1/S Transition | 1.435938e-01 | 0.843 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.460226e-01 | 0.836 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.461607e-01 | 0.835 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.467317e-01 | 0.833 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.467317e-01 | 0.833 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.467317e-01 | 0.833 |
| R-HSA-202433 | Generation of second messenger molecules | 1.467317e-01 | 0.833 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.516795e-01 | 0.819 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.516795e-01 | 0.819 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.516795e-01 | 0.819 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.566600e-01 | 0.805 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.581943e-01 | 0.801 |
| R-HSA-170984 | ARMS-mediated activation | 1.581943e-01 | 0.801 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.581943e-01 | 0.801 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 1.581943e-01 | 0.801 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.581943e-01 | 0.801 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.581943e-01 | 0.801 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.581943e-01 | 0.801 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.581943e-01 | 0.801 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.581943e-01 | 0.801 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.601219e-01 | 0.796 |
| R-HSA-164843 | 2-LTR circle formation | 1.701931e-01 | 0.769 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.701931e-01 | 0.769 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.701931e-01 | 0.769 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.701931e-01 | 0.769 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.768703e-01 | 0.752 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.788698e-01 | 0.747 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.788698e-01 | 0.747 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.815509e-01 | 0.741 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.819860e-01 | 0.740 |
| R-HSA-5682910 | LGI-ADAM interactions | 1.820217e-01 | 0.740 |
| R-HSA-192905 | vRNP Assembly | 1.820217e-01 | 0.740 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 1.820217e-01 | 0.740 |
| R-HSA-425381 | Bicarbonate transporters | 1.820217e-01 | 0.740 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.845396e-01 | 0.734 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.857389e-01 | 0.731 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.922811e-01 | 0.716 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.922811e-01 | 0.716 |
| R-HSA-162592 | Integration of provirus | 1.936824e-01 | 0.713 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.936824e-01 | 0.713 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.936824e-01 | 0.713 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 1.936824e-01 | 0.713 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.936824e-01 | 0.713 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.936824e-01 | 0.713 |
| R-HSA-421270 | Cell-cell junction organization | 1.961075e-01 | 0.708 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.995760e-01 | 0.700 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.003129e-01 | 0.698 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.018902e-01 | 0.695 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 2.048288e-01 | 0.689 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.051776e-01 | 0.688 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 2.051776e-01 | 0.688 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 2.051776e-01 | 0.688 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.051776e-01 | 0.688 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.051776e-01 | 0.688 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 2.051776e-01 | 0.688 |
| R-HSA-69091 | Polymerase switching | 2.051776e-01 | 0.688 |
| R-HSA-69109 | Leading Strand Synthesis | 2.051776e-01 | 0.688 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 2.051776e-01 | 0.688 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.080254e-01 | 0.682 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.130814e-01 | 0.671 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.156438e-01 | 0.666 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.165096e-01 | 0.665 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 2.165096e-01 | 0.665 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.183165e-01 | 0.661 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.263228e-01 | 0.645 |
| R-HSA-913531 | Interferon Signaling | 2.263228e-01 | 0.645 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.276807e-01 | 0.643 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.276807e-01 | 0.643 |
| R-HSA-1989781 | PPARA activates gene expression | 2.379215e-01 | 0.624 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.386932e-01 | 0.622 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.386932e-01 | 0.622 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 2.386932e-01 | 0.622 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.393542e-01 | 0.621 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 2.440726e-01 | 0.612 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.446314e-01 | 0.611 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 2.446314e-01 | 0.611 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.471617e-01 | 0.607 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.495493e-01 | 0.603 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.495493e-01 | 0.603 |
| R-HSA-169893 | Prolonged ERK activation events | 2.495493e-01 | 0.603 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.495493e-01 | 0.603 |
| R-HSA-9754706 | Atorvastatin ADME | 2.495493e-01 | 0.603 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.551984e-01 | 0.593 |
| R-HSA-446728 | Cell junction organization | 2.580349e-01 | 0.588 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.602514e-01 | 0.585 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.602514e-01 | 0.585 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.602514e-01 | 0.585 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.604859e-01 | 0.584 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.651354e-01 | 0.577 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.657745e-01 | 0.575 |
| R-HSA-9707616 | Heme signaling | 2.657745e-01 | 0.575 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 2.657745e-01 | 0.575 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.708014e-01 | 0.567 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.708014e-01 | 0.567 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.708014e-01 | 0.567 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.708014e-01 | 0.567 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.708014e-01 | 0.567 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.708014e-01 | 0.567 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.710631e-01 | 0.567 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.710631e-01 | 0.567 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.710631e-01 | 0.567 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 2.710631e-01 | 0.567 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.812016e-01 | 0.551 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 2.812016e-01 | 0.551 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.812016e-01 | 0.551 |
| R-HSA-5358508 | Mismatch Repair | 2.812016e-01 | 0.551 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.869185e-01 | 0.542 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.905367e-01 | 0.537 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.914541e-01 | 0.535 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.994474e-01 | 0.524 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.015610e-01 | 0.521 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 3.015610e-01 | 0.521 |
| R-HSA-1181150 | Signaling by NODAL | 3.015610e-01 | 0.521 |
| R-HSA-195721 | Signaling by WNT | 3.068929e-01 | 0.513 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.079979e-01 | 0.511 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.093882e-01 | 0.509 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.115244e-01 | 0.507 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.115244e-01 | 0.507 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 3.115244e-01 | 0.507 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 3.115244e-01 | 0.507 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 3.115244e-01 | 0.507 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 3.115244e-01 | 0.507 |
| R-HSA-157118 | Signaling by NOTCH | 3.180971e-01 | 0.497 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.184947e-01 | 0.497 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.184947e-01 | 0.497 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.184947e-01 | 0.497 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.213462e-01 | 0.493 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.213462e-01 | 0.493 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.237295e-01 | 0.490 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.289541e-01 | 0.483 |
| R-HSA-380287 | Centrosome maturation | 3.341678e-01 | 0.476 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.372817e-01 | 0.472 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 3.405733e-01 | 0.468 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.405733e-01 | 0.468 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 3.445592e-01 | 0.463 |
| R-HSA-983712 | Ion channel transport | 3.491100e-01 | 0.457 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.497356e-01 | 0.456 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.499825e-01 | 0.456 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.499825e-01 | 0.456 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.499825e-01 | 0.456 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 3.499825e-01 | 0.456 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.499825e-01 | 0.456 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.499825e-01 | 0.456 |
| R-HSA-1500931 | Cell-Cell communication | 3.521445e-01 | 0.453 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.548982e-01 | 0.450 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 3.592580e-01 | 0.445 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.592580e-01 | 0.445 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.592580e-01 | 0.445 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 3.592580e-01 | 0.445 |
| R-HSA-9833482 | PKR-mediated signaling | 3.600464e-01 | 0.444 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.684017e-01 | 0.434 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.774154e-01 | 0.423 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.774154e-01 | 0.423 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.774154e-01 | 0.423 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.774154e-01 | 0.423 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.863011e-01 | 0.413 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.863011e-01 | 0.413 |
| R-HSA-622312 | Inflammasomes | 3.863011e-01 | 0.413 |
| R-HSA-5620971 | Pyroptosis | 3.863011e-01 | 0.413 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.877235e-01 | 0.411 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.950605e-01 | 0.403 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.950605e-01 | 0.403 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.954166e-01 | 0.403 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.956280e-01 | 0.403 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.036954e-01 | 0.394 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.036954e-01 | 0.394 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 4.036954e-01 | 0.394 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.036954e-01 | 0.394 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.056313e-01 | 0.392 |
| R-HSA-9645723 | Diseases of programmed cell death | 4.056313e-01 | 0.392 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.155549e-01 | 0.381 |
| R-HSA-73884 | Base Excision Repair | 4.155549e-01 | 0.381 |
| R-HSA-69190 | DNA strand elongation | 4.205987e-01 | 0.376 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.253954e-01 | 0.371 |
| R-HSA-166520 | Signaling by NTRKs | 4.259138e-01 | 0.371 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 4.288706e-01 | 0.368 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.288706e-01 | 0.368 |
| R-HSA-9930044 | Nuclear RNA decay | 4.288706e-01 | 0.368 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.288706e-01 | 0.368 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.288706e-01 | 0.368 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.288706e-01 | 0.368 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.370250e-01 | 0.359 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 4.370250e-01 | 0.359 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.370250e-01 | 0.359 |
| R-HSA-189483 | Heme degradation | 4.370250e-01 | 0.359 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.450633e-01 | 0.352 |
| R-HSA-203615 | eNOS activation | 4.450633e-01 | 0.352 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 4.450633e-01 | 0.352 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.450633e-01 | 0.352 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.484362e-01 | 0.348 |
| R-HSA-187687 | Signalling to ERKs | 4.529874e-01 | 0.344 |
| R-HSA-381042 | PERK regulates gene expression | 4.529874e-01 | 0.344 |
| R-HSA-8951664 | Neddylation | 4.548474e-01 | 0.342 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.558667e-01 | 0.341 |
| R-HSA-157579 | Telomere Maintenance | 4.591377e-01 | 0.338 |
| R-HSA-9610379 | HCMV Late Events | 4.595657e-01 | 0.338 |
| R-HSA-111933 | Calmodulin induced events | 4.607989e-01 | 0.336 |
| R-HSA-111997 | CaM pathway | 4.607989e-01 | 0.336 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 4.607989e-01 | 0.336 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.684992e-01 | 0.329 |
| R-HSA-70171 | Glycolysis | 4.732456e-01 | 0.325 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.751592e-01 | 0.323 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 4.760901e-01 | 0.322 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.760901e-01 | 0.322 |
| R-HSA-1483255 | PI Metabolism | 4.825274e-01 | 0.316 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.835730e-01 | 0.316 |
| R-HSA-201556 | Signaling by ALK | 4.835730e-01 | 0.316 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.909495e-01 | 0.309 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.909495e-01 | 0.309 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.909495e-01 | 0.309 |
| R-HSA-167169 | HIV Transcription Elongation | 4.909495e-01 | 0.309 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.909495e-01 | 0.309 |
| R-HSA-5260271 | Diseases of Immune System | 4.909495e-01 | 0.309 |
| R-HSA-5663205 | Infectious disease | 4.937784e-01 | 0.306 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.982211e-01 | 0.303 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.982211e-01 | 0.303 |
| R-HSA-8939211 | ESR-mediated signaling | 5.042242e-01 | 0.297 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.053892e-01 | 0.296 |
| R-HSA-162582 | Signal Transduction | 5.090098e-01 | 0.293 |
| R-HSA-72306 | tRNA processing | 5.101490e-01 | 0.292 |
| R-HSA-111996 | Ca-dependent events | 5.124554e-01 | 0.290 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.241461e-01 | 0.281 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.262876e-01 | 0.279 |
| R-HSA-9907900 | Proteasome assembly | 5.262876e-01 | 0.279 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.262876e-01 | 0.279 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.317294e-01 | 0.274 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.330565e-01 | 0.273 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.330565e-01 | 0.273 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.393446e-01 | 0.268 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.394116e-01 | 0.268 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.397291e-01 | 0.268 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 5.397291e-01 | 0.268 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 5.397291e-01 | 0.268 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 5.397291e-01 | 0.268 |
| R-HSA-9609646 | HCMV Infection | 5.428591e-01 | 0.265 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.527907e-01 | 0.257 |
| R-HSA-70326 | Glucose metabolism | 5.613458e-01 | 0.251 |
| R-HSA-2514856 | The phototransduction cascade | 5.716944e-01 | 0.243 |
| R-HSA-212436 | Generic Transcription Pathway | 5.821890e-01 | 0.235 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.838527e-01 | 0.234 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.856521e-01 | 0.232 |
| R-HSA-418597 | G alpha (z) signalling events | 5.956673e-01 | 0.225 |
| R-HSA-9753281 | Paracetamol ADME | 5.956673e-01 | 0.225 |
| R-HSA-9609690 | HCMV Early Events | 5.969956e-01 | 0.224 |
| R-HSA-193648 | NRAGE signals death through JNK | 6.014487e-01 | 0.221 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.014487e-01 | 0.221 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.014487e-01 | 0.221 |
| R-HSA-114608 | Platelet degranulation | 6.051395e-01 | 0.218 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 6.071478e-01 | 0.217 |
| R-HSA-180786 | Extension of Telomeres | 6.183038e-01 | 0.209 |
| R-HSA-186712 | Regulation of beta-cell development | 6.183038e-01 | 0.209 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 6.183038e-01 | 0.209 |
| R-HSA-8873719 | RAB geranylgeranylation | 6.237629e-01 | 0.205 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.237629e-01 | 0.205 |
| R-HSA-597592 | Post-translational protein modification | 6.250795e-01 | 0.204 |
| R-HSA-112043 | PLC beta mediated events | 6.291443e-01 | 0.201 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 6.291443e-01 | 0.201 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.312485e-01 | 0.200 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 6.344491e-01 | 0.198 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.443862e-01 | 0.191 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.549231e-01 | 0.184 |
| R-HSA-1643685 | Disease | 6.572820e-01 | 0.182 |
| R-HSA-112040 | G-protein mediated events | 6.598606e-01 | 0.181 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 6.598606e-01 | 0.181 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.647278e-01 | 0.177 |
| R-HSA-167172 | Transcription of the HIV genome | 6.647278e-01 | 0.177 |
| R-HSA-8978934 | Metabolism of cofactors | 6.789171e-01 | 0.168 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.789171e-01 | 0.168 |
| R-HSA-189445 | Metabolism of porphyrins | 6.789171e-01 | 0.168 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.805045e-01 | 0.167 |
| R-HSA-9749641 | Aspirin ADME | 6.880429e-01 | 0.162 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.097432e-01 | 0.149 |
| R-HSA-9659379 | Sensory processing of sound | 7.138994e-01 | 0.146 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.179964e-01 | 0.144 |
| R-HSA-392499 | Metabolism of proteins | 7.270376e-01 | 0.138 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.299401e-01 | 0.137 |
| R-HSA-5619102 | SLC transporter disorders | 7.446263e-01 | 0.128 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.450851e-01 | 0.128 |
| R-HSA-199991 | Membrane Trafficking | 7.468284e-01 | 0.127 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.487372e-01 | 0.126 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.487372e-01 | 0.126 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.623730e-01 | 0.118 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.628324e-01 | 0.118 |
| R-HSA-391251 | Protein folding | 7.695818e-01 | 0.114 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.761400e-01 | 0.110 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.947201e-01 | 0.100 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.005657e-01 | 0.097 |
| R-HSA-5617833 | Cilium Assembly | 8.025209e-01 | 0.096 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.034261e-01 | 0.095 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.067795e-01 | 0.093 |
| R-HSA-111885 | Opioid Signalling | 8.090248e-01 | 0.092 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 8.117643e-01 | 0.091 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 8.117643e-01 | 0.091 |
| R-HSA-6798695 | Neutrophil degranulation | 8.177139e-01 | 0.087 |
| R-HSA-1266738 | Developmental Biology | 8.286038e-01 | 0.082 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 8.323175e-01 | 0.080 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 8.347243e-01 | 0.078 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.447132e-01 | 0.073 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.484998e-01 | 0.071 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.630532e-01 | 0.064 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.669596e-01 | 0.062 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.669596e-01 | 0.062 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.669596e-01 | 0.062 |
| R-HSA-168249 | Innate Immune System | 8.789121e-01 | 0.056 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.812217e-01 | 0.055 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.815068e-01 | 0.055 |
| R-HSA-5668914 | Diseases of metabolism | 8.864338e-01 | 0.052 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.987538e-01 | 0.046 |
| R-HSA-1280218 | Adaptive Immune System | 9.035029e-01 | 0.044 |
| R-HSA-2187338 | Visual phototransduction | 9.073717e-01 | 0.042 |
| R-HSA-9758941 | Gastrulation | 9.100183e-01 | 0.041 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.113133e-01 | 0.040 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 9.113133e-01 | 0.040 |
| R-HSA-382551 | Transport of small molecules | 9.141404e-01 | 0.039 |
| R-HSA-416476 | G alpha (q) signalling events | 9.155783e-01 | 0.038 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.249436e-01 | 0.034 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 9.391814e-01 | 0.027 |
| R-HSA-1483257 | Phospholipid metabolism | 9.415249e-01 | 0.026 |
| R-HSA-8957322 | Metabolism of steroids | 9.588032e-01 | 0.018 |
| R-HSA-6805567 | Keratinization | 9.618019e-01 | 0.017 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.649956e-01 | 0.015 |
| R-HSA-397014 | Muscle contraction | 9.649956e-01 | 0.015 |
| R-HSA-9748784 | Drug ADME | 9.679234e-01 | 0.014 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.835513e-01 | 0.007 |
| R-HSA-418594 | G alpha (i) signalling events | 9.855044e-01 | 0.006 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.866322e-01 | 0.006 |
| R-HSA-9658195 | Leishmania infection | 9.872057e-01 | 0.006 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.872057e-01 | 0.006 |
| R-HSA-168256 | Immune System | 9.883614e-01 | 0.005 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.930814e-01 | 0.003 |
| R-HSA-1474244 | Extracellular matrix organization | 9.938471e-01 | 0.003 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.962096e-01 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 9.969286e-01 | 0.001 |
| R-HSA-109582 | Hemostasis | 9.972622e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.988336e-01 | 0.001 |
| R-HSA-112316 | Neuronal System | 9.991941e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.996433e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999895e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999999e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CK2A2 |
0.853 | 0.607 | 1 | 0.869 |
CLK3 |
0.851 | 0.228 | 1 | 0.708 |
MOS |
0.847 | 0.425 | 1 | 0.865 |
CDC7 |
0.846 | 0.265 | 1 | 0.860 |
COT |
0.845 | 0.152 | 2 | 0.824 |
FAM20C |
0.844 | 0.286 | 2 | 0.748 |
CK2A1 |
0.844 | 0.566 | 1 | 0.851 |
BMPR1B |
0.838 | 0.314 | 1 | 0.757 |
PIM3 |
0.836 | 0.147 | -3 | 0.875 |
CAMK2G |
0.836 | 0.189 | 2 | 0.842 |
GRK1 |
0.835 | 0.224 | -2 | 0.812 |
GRK6 |
0.835 | 0.280 | 1 | 0.723 |
CAMK2B |
0.834 | 0.263 | 2 | 0.841 |
NDR2 |
0.833 | 0.120 | -3 | 0.868 |
GRK7 |
0.829 | 0.272 | 1 | 0.651 |
RSK2 |
0.829 | 0.143 | -3 | 0.828 |
PIM1 |
0.829 | 0.167 | -3 | 0.837 |
BMPR1A |
0.828 | 0.312 | 1 | 0.762 |
TGFBR1 |
0.828 | 0.265 | -2 | 0.858 |
CAMK2A |
0.828 | 0.222 | 2 | 0.854 |
CAMK1B |
0.827 | 0.089 | -3 | 0.896 |
PRPK |
0.826 | -0.015 | -1 | 0.813 |
ALK2 |
0.826 | 0.331 | -2 | 0.863 |
DSTYK |
0.826 | 0.055 | 2 | 0.853 |
IKKB |
0.825 | -0.002 | -2 | 0.741 |
CLK2 |
0.824 | 0.193 | -3 | 0.821 |
RAF1 |
0.823 | -0.041 | 1 | 0.691 |
GRK5 |
0.822 | 0.066 | -3 | 0.855 |
MAPKAPK2 |
0.821 | 0.144 | -3 | 0.780 |
MTOR |
0.820 | -0.082 | 1 | 0.624 |
LATS1 |
0.820 | 0.188 | -3 | 0.880 |
LATS2 |
0.820 | 0.079 | -5 | 0.748 |
ACVR2B |
0.820 | 0.226 | -2 | 0.847 |
BMPR2 |
0.819 | -0.026 | -2 | 0.875 |
ATM |
0.819 | 0.065 | 1 | 0.627 |
SKMLCK |
0.819 | 0.055 | -2 | 0.825 |
RSK4 |
0.819 | 0.149 | -3 | 0.805 |
IKKA |
0.819 | 0.064 | -2 | 0.730 |
SRPK1 |
0.818 | 0.073 | -3 | 0.806 |
PKN3 |
0.818 | 0.029 | -3 | 0.861 |
PRKX |
0.818 | 0.180 | -3 | 0.753 |
CDKL1 |
0.817 | 0.042 | -3 | 0.845 |
GRK4 |
0.817 | 0.073 | -2 | 0.833 |
NDR1 |
0.817 | 0.037 | -3 | 0.868 |
PDHK4 |
0.817 | -0.172 | 1 | 0.701 |
ATR |
0.817 | -0.037 | 1 | 0.671 |
P90RSK |
0.817 | 0.072 | -3 | 0.830 |
ALK4 |
0.816 | 0.174 | -2 | 0.875 |
ACVR2A |
0.815 | 0.182 | -2 | 0.835 |
KIS |
0.815 | 0.031 | 1 | 0.560 |
GCN2 |
0.815 | -0.169 | 2 | 0.743 |
P70S6KB |
0.814 | 0.076 | -3 | 0.848 |
CAMLCK |
0.814 | 0.020 | -2 | 0.827 |
CAMK2D |
0.813 | 0.053 | -3 | 0.857 |
PLK3 |
0.813 | 0.124 | 2 | 0.789 |
PRKD1 |
0.813 | 0.015 | -3 | 0.834 |
TBK1 |
0.813 | -0.145 | 1 | 0.567 |
DAPK2 |
0.812 | 0.036 | -3 | 0.891 |
NUAK2 |
0.812 | 0.003 | -3 | 0.882 |
PRKD2 |
0.812 | 0.054 | -3 | 0.817 |
NIK |
0.811 | -0.053 | -3 | 0.898 |
SRPK2 |
0.811 | 0.075 | -3 | 0.745 |
MSK1 |
0.811 | 0.106 | -3 | 0.790 |
NLK |
0.811 | -0.103 | 1 | 0.666 |
IKKE |
0.810 | -0.138 | 1 | 0.562 |
RSK3 |
0.810 | 0.041 | -3 | 0.821 |
PKACG |
0.809 | 0.045 | -2 | 0.751 |
MSK2 |
0.809 | 0.058 | -3 | 0.788 |
TGFBR2 |
0.809 | -0.036 | -2 | 0.844 |
MST4 |
0.809 | -0.042 | 2 | 0.773 |
PKACB |
0.809 | 0.109 | -2 | 0.683 |
PLK1 |
0.809 | 0.048 | -2 | 0.816 |
HUNK |
0.808 | -0.095 | 2 | 0.771 |
MARK4 |
0.808 | -0.038 | 4 | 0.765 |
TSSK2 |
0.808 | 0.018 | -5 | 0.815 |
CLK4 |
0.807 | 0.076 | -3 | 0.834 |
ERK5 |
0.807 | -0.097 | 1 | 0.630 |
AMPKA1 |
0.807 | -0.011 | -3 | 0.878 |
NEK6 |
0.806 | -0.117 | -2 | 0.844 |
PKN2 |
0.806 | -0.040 | -3 | 0.861 |
PKCD |
0.806 | -0.020 | 2 | 0.719 |
MAPKAPK3 |
0.805 | 0.012 | -3 | 0.809 |
PASK |
0.805 | 0.171 | -3 | 0.875 |
WNK1 |
0.805 | -0.095 | -2 | 0.825 |
PDHK1 |
0.805 | -0.253 | 1 | 0.674 |
ULK2 |
0.805 | -0.254 | 2 | 0.710 |
SRPK3 |
0.804 | 0.046 | -3 | 0.784 |
DNAPK |
0.804 | 0.053 | 1 | 0.534 |
AURA |
0.804 | 0.053 | -2 | 0.619 |
AURC |
0.804 | 0.035 | -2 | 0.660 |
CDKL5 |
0.804 | -0.012 | -3 | 0.833 |
NEK7 |
0.803 | -0.199 | -3 | 0.824 |
ICK |
0.803 | -0.015 | -3 | 0.868 |
DLK |
0.803 | -0.116 | 1 | 0.658 |
MLK1 |
0.802 | -0.173 | 2 | 0.744 |
GRK2 |
0.802 | 0.029 | -2 | 0.734 |
CAMK4 |
0.802 | -0.031 | -3 | 0.858 |
RIPK3 |
0.802 | -0.185 | 3 | 0.631 |
JNK3 |
0.802 | 0.033 | 1 | 0.534 |
JNK2 |
0.801 | 0.037 | 1 | 0.499 |
MYLK4 |
0.801 | 0.037 | -2 | 0.758 |
PAK1 |
0.800 | -0.007 | -2 | 0.753 |
DYRK2 |
0.800 | 0.006 | 1 | 0.546 |
MEK1 |
0.800 | -0.023 | 2 | 0.801 |
CDK1 |
0.800 | 0.001 | 1 | 0.520 |
AMPKA2 |
0.799 | -0.016 | -3 | 0.855 |
HIPK4 |
0.799 | -0.056 | 1 | 0.625 |
TSSK1 |
0.799 | -0.022 | -3 | 0.892 |
CLK1 |
0.799 | 0.056 | -3 | 0.811 |
DRAK1 |
0.799 | 0.009 | 1 | 0.645 |
GSK3A |
0.799 | 0.120 | 4 | 0.532 |
MASTL |
0.798 | -0.264 | -2 | 0.783 |
BCKDK |
0.798 | -0.178 | -1 | 0.762 |
ULK1 |
0.797 | -0.221 | -3 | 0.802 |
PIM2 |
0.797 | 0.079 | -3 | 0.806 |
CHAK2 |
0.797 | -0.156 | -1 | 0.792 |
DYRK4 |
0.796 | 0.056 | 1 | 0.500 |
ANKRD3 |
0.795 | -0.213 | 1 | 0.664 |
PLK2 |
0.795 | 0.122 | -3 | 0.814 |
BRSK1 |
0.795 | -0.009 | -3 | 0.837 |
CHK1 |
0.795 | 0.016 | -3 | 0.846 |
TTBK2 |
0.795 | -0.152 | 2 | 0.634 |
PRKD3 |
0.794 | 0.005 | -3 | 0.797 |
CDK8 |
0.794 | -0.063 | 1 | 0.524 |
PKR |
0.794 | -0.107 | 1 | 0.676 |
NIM1 |
0.794 | -0.118 | 3 | 0.667 |
GRK3 |
0.794 | 0.055 | -2 | 0.702 |
AURB |
0.794 | 0.006 | -2 | 0.654 |
BRAF |
0.794 | 0.004 | -4 | 0.813 |
AKT2 |
0.793 | 0.058 | -3 | 0.762 |
WNK3 |
0.793 | -0.285 | 1 | 0.634 |
SIK |
0.793 | -0.014 | -3 | 0.818 |
QSK |
0.792 | -0.040 | 4 | 0.734 |
MARK3 |
0.792 | -0.018 | 4 | 0.703 |
PKACA |
0.792 | 0.086 | -2 | 0.642 |
CAMK1G |
0.792 | 0.004 | -3 | 0.821 |
MLK3 |
0.791 | -0.119 | 2 | 0.676 |
RIPK1 |
0.791 | -0.254 | 1 | 0.627 |
YSK4 |
0.791 | -0.150 | 1 | 0.607 |
PKCG |
0.790 | -0.067 | 2 | 0.670 |
DCAMKL1 |
0.790 | 0.022 | -3 | 0.838 |
PAK3 |
0.790 | -0.093 | -2 | 0.754 |
NUAK1 |
0.789 | -0.062 | -3 | 0.844 |
MNK1 |
0.789 | -0.035 | -2 | 0.784 |
TLK2 |
0.789 | -0.067 | 1 | 0.603 |
MARK2 |
0.789 | -0.036 | 4 | 0.660 |
PKCB |
0.789 | -0.063 | 2 | 0.663 |
SGK3 |
0.789 | 0.027 | -3 | 0.801 |
GSK3B |
0.788 | 0.056 | 4 | 0.518 |
PAK2 |
0.788 | -0.069 | -2 | 0.738 |
MELK |
0.788 | -0.082 | -3 | 0.841 |
HIPK2 |
0.788 | 0.012 | 1 | 0.484 |
CAMK1D |
0.787 | 0.072 | -3 | 0.758 |
NEK9 |
0.787 | -0.312 | 2 | 0.742 |
MEKK3 |
0.787 | -0.107 | 1 | 0.616 |
QIK |
0.787 | -0.137 | -3 | 0.857 |
IRE2 |
0.787 | -0.153 | 2 | 0.668 |
MARK1 |
0.787 | -0.043 | 4 | 0.722 |
PKCA |
0.786 | -0.084 | 2 | 0.651 |
PKG2 |
0.786 | 0.004 | -2 | 0.693 |
DAPK3 |
0.786 | 0.092 | -3 | 0.854 |
SMG1 |
0.786 | -0.103 | 1 | 0.621 |
MLK4 |
0.786 | -0.134 | 2 | 0.655 |
CDK5 |
0.786 | -0.052 | 1 | 0.565 |
GAK |
0.786 | 0.059 | 1 | 0.699 |
PAK6 |
0.786 | -0.023 | -2 | 0.678 |
MNK2 |
0.785 | -0.080 | -2 | 0.765 |
TLK1 |
0.785 | -0.049 | -2 | 0.853 |
P38B |
0.785 | -0.022 | 1 | 0.497 |
P38G |
0.785 | -0.016 | 1 | 0.439 |
SMMLCK |
0.785 | 0.000 | -3 | 0.854 |
CDK19 |
0.785 | -0.074 | 1 | 0.490 |
CDK3 |
0.785 | -0.008 | 1 | 0.471 |
P38A |
0.785 | -0.052 | 1 | 0.549 |
PKCH |
0.785 | -0.093 | 2 | 0.650 |
HIPK1 |
0.785 | -0.003 | 1 | 0.561 |
DAPK1 |
0.785 | 0.095 | -3 | 0.838 |
CDK2 |
0.784 | -0.067 | 1 | 0.576 |
CDK13 |
0.784 | -0.076 | 1 | 0.531 |
CK1E |
0.784 | -0.003 | -3 | 0.570 |
CDK7 |
0.784 | -0.086 | 1 | 0.556 |
IRE1 |
0.784 | -0.229 | 1 | 0.615 |
CDK18 |
0.784 | -0.046 | 1 | 0.491 |
PRP4 |
0.783 | -0.010 | -3 | 0.774 |
MLK2 |
0.783 | -0.312 | 2 | 0.734 |
DCAMKL2 |
0.783 | -0.018 | -3 | 0.860 |
VRK2 |
0.783 | -0.397 | 1 | 0.693 |
JNK1 |
0.783 | 0.017 | 1 | 0.507 |
DYRK1B |
0.782 | 0.002 | 1 | 0.521 |
CDK17 |
0.782 | -0.046 | 1 | 0.450 |
DYRK1A |
0.781 | -0.012 | 1 | 0.593 |
BRSK2 |
0.780 | -0.117 | -3 | 0.849 |
P70S6K |
0.780 | 0.010 | -3 | 0.763 |
ERK2 |
0.780 | -0.075 | 1 | 0.528 |
MAPKAPK5 |
0.779 | -0.085 | -3 | 0.759 |
TAO3 |
0.779 | -0.087 | 1 | 0.625 |
CK1D |
0.779 | 0.009 | -3 | 0.517 |
SSTK |
0.778 | -0.039 | 4 | 0.708 |
ERK1 |
0.778 | -0.061 | 1 | 0.486 |
DYRK3 |
0.778 | 0.004 | 1 | 0.556 |
AKT1 |
0.778 | 0.024 | -3 | 0.771 |
PERK |
0.778 | -0.189 | -2 | 0.851 |
P38D |
0.777 | -0.009 | 1 | 0.460 |
PKCZ |
0.777 | -0.160 | 2 | 0.686 |
PLK4 |
0.777 | -0.175 | 2 | 0.597 |
PHKG1 |
0.777 | -0.156 | -3 | 0.861 |
SGK1 |
0.777 | 0.089 | -3 | 0.682 |
NEK2 |
0.777 | -0.241 | 2 | 0.712 |
PINK1 |
0.776 | -0.198 | 1 | 0.668 |
CDK12 |
0.776 | -0.074 | 1 | 0.502 |
MEK5 |
0.776 | -0.308 | 2 | 0.760 |
SNRK |
0.776 | -0.206 | 2 | 0.632 |
MEKK2 |
0.776 | -0.191 | 2 | 0.727 |
MST3 |
0.775 | -0.117 | 2 | 0.760 |
HRI |
0.775 | -0.238 | -2 | 0.853 |
CDK10 |
0.775 | -0.017 | 1 | 0.513 |
CDK14 |
0.774 | -0.051 | 1 | 0.521 |
CDK16 |
0.774 | -0.023 | 1 | 0.469 |
ZAK |
0.773 | -0.230 | 1 | 0.590 |
CDK9 |
0.773 | -0.100 | 1 | 0.529 |
MEKK1 |
0.773 | -0.270 | 1 | 0.616 |
MRCKA |
0.773 | 0.059 | -3 | 0.812 |
SBK |
0.773 | 0.091 | -3 | 0.655 |
CK1A2 |
0.772 | -0.019 | -3 | 0.520 |
CHAK1 |
0.772 | -0.284 | 2 | 0.658 |
HIPK3 |
0.770 | -0.067 | 1 | 0.545 |
CAMKK1 |
0.770 | -0.170 | -2 | 0.736 |
WNK4 |
0.769 | -0.225 | -2 | 0.807 |
NEK5 |
0.769 | -0.271 | 1 | 0.633 |
GCK |
0.769 | -0.097 | 1 | 0.620 |
PKCT |
0.768 | -0.113 | 2 | 0.652 |
AKT3 |
0.768 | 0.044 | -3 | 0.697 |
TAO2 |
0.768 | -0.154 | 2 | 0.771 |
PDHK3_TYR |
0.768 | 0.350 | 4 | 0.866 |
MST2 |
0.768 | -0.116 | 1 | 0.629 |
TAK1 |
0.768 | -0.095 | 1 | 0.648 |
NEK8 |
0.767 | -0.220 | 2 | 0.735 |
PHKG2 |
0.767 | -0.118 | -3 | 0.846 |
EEF2K |
0.767 | -0.092 | 3 | 0.700 |
MRCKB |
0.767 | 0.033 | -3 | 0.796 |
DMPK1 |
0.767 | 0.087 | -3 | 0.823 |
TTBK1 |
0.766 | -0.184 | 2 | 0.568 |
CK1G1 |
0.766 | -0.078 | -3 | 0.578 |
PKCE |
0.766 | -0.043 | 2 | 0.650 |
PDK1 |
0.766 | -0.148 | 1 | 0.629 |
PAK5 |
0.766 | -0.060 | -2 | 0.619 |
ALPHAK3 |
0.766 | 0.102 | -1 | 0.752 |
ROCK2 |
0.765 | 0.034 | -3 | 0.830 |
LKB1 |
0.765 | -0.169 | -3 | 0.821 |
CAMKK2 |
0.765 | -0.177 | -2 | 0.730 |
MPSK1 |
0.764 | -0.139 | 1 | 0.624 |
CAMK1A |
0.764 | 0.014 | -3 | 0.725 |
PAK4 |
0.764 | -0.052 | -2 | 0.620 |
CHK2 |
0.763 | -0.001 | -3 | 0.711 |
IRAK4 |
0.763 | -0.274 | 1 | 0.609 |
PKCI |
0.762 | -0.129 | 2 | 0.658 |
PDHK4_TYR |
0.762 | 0.250 | 2 | 0.856 |
NEK11 |
0.762 | -0.290 | 1 | 0.609 |
MAP2K6_TYR |
0.761 | 0.236 | -1 | 0.847 |
HPK1 |
0.761 | -0.123 | 1 | 0.606 |
TNIK |
0.760 | -0.140 | 3 | 0.702 |
MAK |
0.759 | 0.010 | -2 | 0.675 |
MST1 |
0.759 | -0.148 | 1 | 0.605 |
PDHK1_TYR |
0.758 | 0.216 | -1 | 0.864 |
ERK7 |
0.758 | -0.087 | 2 | 0.458 |
PKN1 |
0.758 | -0.065 | -3 | 0.779 |
LRRK2 |
0.757 | -0.236 | 2 | 0.769 |
MINK |
0.757 | -0.209 | 1 | 0.599 |
IRAK1 |
0.756 | -0.333 | -1 | 0.693 |
SLK |
0.756 | -0.131 | -2 | 0.713 |
MAP2K4_TYR |
0.756 | 0.146 | -1 | 0.845 |
CDK4 |
0.755 | -0.071 | 1 | 0.495 |
CRIK |
0.755 | 0.054 | -3 | 0.762 |
CDK6 |
0.755 | -0.082 | 1 | 0.503 |
HGK |
0.754 | -0.213 | 3 | 0.703 |
BMPR2_TYR |
0.754 | 0.095 | -1 | 0.848 |
KHS2 |
0.754 | -0.096 | 1 | 0.604 |
MEK2 |
0.752 | -0.226 | 2 | 0.742 |
NEK4 |
0.752 | -0.314 | 1 | 0.597 |
TTK |
0.752 | -0.059 | -2 | 0.832 |
TESK1_TYR |
0.752 | -0.013 | 3 | 0.758 |
LOK |
0.751 | -0.186 | -2 | 0.761 |
PBK |
0.751 | -0.091 | 1 | 0.627 |
MOK |
0.751 | -0.024 | 1 | 0.560 |
BUB1 |
0.751 | -0.064 | -5 | 0.779 |
KHS1 |
0.751 | -0.150 | 1 | 0.592 |
STK33 |
0.750 | -0.201 | 2 | 0.575 |
VRK1 |
0.750 | -0.308 | 2 | 0.770 |
ROCK1 |
0.750 | 0.010 | -3 | 0.807 |
MAP3K15 |
0.750 | -0.290 | 1 | 0.574 |
NEK1 |
0.750 | -0.290 | 1 | 0.609 |
YANK3 |
0.750 | -0.059 | 2 | 0.400 |
MAP2K7_TYR |
0.748 | -0.070 | 2 | 0.821 |
EPHA4 |
0.748 | 0.119 | 2 | 0.802 |
EPHA6 |
0.748 | 0.063 | -1 | 0.843 |
RIPK2 |
0.747 | -0.299 | 1 | 0.566 |
PINK1_TYR |
0.746 | -0.078 | 1 | 0.697 |
TXK |
0.746 | 0.152 | 1 | 0.771 |
MEKK6 |
0.746 | -0.333 | 1 | 0.589 |
OSR1 |
0.745 | -0.135 | 2 | 0.712 |
HASPIN |
0.745 | -0.059 | -1 | 0.651 |
YSK1 |
0.743 | -0.234 | 2 | 0.710 |
BIKE |
0.742 | -0.060 | 1 | 0.594 |
PKG1 |
0.742 | -0.042 | -2 | 0.625 |
PKMYT1_TYR |
0.741 | -0.188 | 3 | 0.730 |
EPHB4 |
0.741 | 0.004 | -1 | 0.821 |
CK1A |
0.739 | -0.032 | -3 | 0.432 |
INSRR |
0.738 | -0.003 | 3 | 0.620 |
SRMS |
0.738 | 0.055 | 1 | 0.736 |
FER |
0.737 | -0.000 | 1 | 0.752 |
EPHB2 |
0.736 | 0.057 | -1 | 0.805 |
LIMK2_TYR |
0.735 | -0.163 | -3 | 0.881 |
YES1 |
0.735 | -0.032 | -1 | 0.787 |
ASK1 |
0.734 | -0.249 | 1 | 0.577 |
BLK |
0.733 | 0.057 | -1 | 0.795 |
EPHB1 |
0.733 | -0.017 | 1 | 0.703 |
EPHB3 |
0.733 | 0.002 | -1 | 0.803 |
RET |
0.732 | -0.209 | 1 | 0.611 |
EPHA5 |
0.732 | 0.092 | 2 | 0.797 |
MYO3A |
0.732 | -0.204 | 1 | 0.599 |
DDR1 |
0.731 | -0.149 | 4 | 0.757 |
FYN |
0.731 | 0.055 | -1 | 0.761 |
PTK2 |
0.730 | 0.098 | -1 | 0.788 |
FGR |
0.730 | -0.101 | 1 | 0.681 |
LIMK1_TYR |
0.729 | -0.268 | 2 | 0.782 |
MYO3B |
0.729 | -0.222 | 2 | 0.725 |
FGFR2 |
0.729 | -0.098 | 3 | 0.674 |
JAK3 |
0.729 | -0.125 | 1 | 0.609 |
TAO1 |
0.728 | -0.216 | 1 | 0.545 |
LCK |
0.728 | -0.021 | -1 | 0.785 |
SYK |
0.727 | 0.117 | -1 | 0.780 |
EPHA7 |
0.727 | -0.014 | 2 | 0.781 |
TYRO3 |
0.727 | -0.232 | 3 | 0.654 |
ABL2 |
0.727 | -0.109 | -1 | 0.765 |
FLT1 |
0.726 | -0.026 | -1 | 0.838 |
EPHA3 |
0.726 | -0.034 | 2 | 0.764 |
ITK |
0.726 | -0.078 | -1 | 0.748 |
HCK |
0.726 | -0.093 | -1 | 0.780 |
NEK3 |
0.725 | -0.365 | 1 | 0.556 |
MST1R |
0.725 | -0.280 | 3 | 0.669 |
CSF1R |
0.725 | -0.205 | 3 | 0.647 |
AAK1 |
0.724 | -0.037 | 1 | 0.504 |
KIT |
0.723 | -0.141 | 3 | 0.658 |
TYK2 |
0.723 | -0.346 | 1 | 0.606 |
FGFR3 |
0.723 | -0.072 | 3 | 0.651 |
BMX |
0.722 | -0.053 | -1 | 0.671 |
ROS1 |
0.722 | -0.277 | 3 | 0.622 |
STLK3 |
0.721 | -0.244 | 1 | 0.565 |
TEC |
0.721 | -0.076 | -1 | 0.682 |
EPHA8 |
0.721 | -0.002 | -1 | 0.788 |
JAK2 |
0.720 | -0.323 | 1 | 0.597 |
MERTK |
0.720 | -0.108 | 3 | 0.639 |
TNK2 |
0.720 | -0.157 | 3 | 0.624 |
CK1G3 |
0.720 | -0.037 | -3 | 0.387 |
EGFR |
0.719 | -0.017 | 1 | 0.519 |
ABL1 |
0.719 | -0.160 | -1 | 0.752 |
KDR |
0.719 | -0.167 | 3 | 0.619 |
FLT3 |
0.719 | -0.205 | 3 | 0.646 |
TEK |
0.718 | -0.183 | 3 | 0.604 |
ERBB2 |
0.717 | -0.127 | 1 | 0.597 |
FGFR1 |
0.717 | -0.194 | 3 | 0.642 |
LYN |
0.716 | -0.066 | 3 | 0.602 |
MET |
0.716 | -0.137 | 3 | 0.644 |
PTK2B |
0.716 | -0.052 | -1 | 0.711 |
NTRK1 |
0.715 | -0.171 | -1 | 0.785 |
AXL |
0.715 | -0.194 | 3 | 0.645 |
NEK10_TYR |
0.715 | -0.205 | 1 | 0.533 |
FRK |
0.715 | -0.098 | -1 | 0.805 |
PDGFRB |
0.715 | -0.281 | 3 | 0.660 |
YANK2 |
0.715 | -0.088 | 2 | 0.418 |
EPHA2 |
0.714 | 0.003 | -1 | 0.769 |
LTK |
0.713 | -0.169 | 3 | 0.613 |
CK1G2 |
0.713 | -0.014 | -3 | 0.488 |
DDR2 |
0.713 | -0.080 | 3 | 0.615 |
BTK |
0.713 | -0.207 | -1 | 0.706 |
SRC |
0.713 | -0.065 | -1 | 0.753 |
FLT4 |
0.712 | -0.167 | 3 | 0.625 |
FGFR4 |
0.712 | -0.053 | -1 | 0.754 |
ERBB4 |
0.711 | -0.009 | 1 | 0.561 |
ALK |
0.710 | -0.212 | 3 | 0.589 |
WEE1_TYR |
0.709 | -0.190 | -1 | 0.699 |
INSR |
0.709 | -0.178 | 3 | 0.601 |
CSK |
0.709 | -0.117 | 2 | 0.774 |
EPHA1 |
0.708 | -0.178 | 3 | 0.618 |
MATK |
0.708 | -0.125 | -1 | 0.700 |
PTK6 |
0.708 | -0.237 | -1 | 0.674 |
TNK1 |
0.707 | -0.278 | 3 | 0.639 |
IGF1R |
0.705 | -0.098 | 3 | 0.559 |
NTRK2 |
0.705 | -0.253 | 3 | 0.624 |
NTRK3 |
0.704 | -0.172 | -1 | 0.739 |
TNNI3K_TYR |
0.704 | -0.250 | 1 | 0.604 |
JAK1 |
0.703 | -0.283 | 1 | 0.547 |
PDGFRA |
0.702 | -0.376 | 3 | 0.651 |
ZAP70 |
0.689 | -0.040 | -1 | 0.676 |
FES |
0.684 | -0.153 | -1 | 0.645 |
MUSK |
0.684 | -0.233 | 1 | 0.503 |