Motif 691 (n=49)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
P0CG47	UBB	S20	ochoa	Polyubiquitin-B [Cleaved into: Ubiquitin]	[Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:34239127, ECO:0000303\|PubMed:19754430}.
P0CG48	UBC	S20	ochoa	Polyubiquitin-C [Cleaved into: Ubiquitin]	[Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:34239127, ECO:0000269\|PubMed:38326650, ECO:0000269\|PubMed:39548056, ECO:0000303\|PubMed:19754430}.
P62979	RPS27A	S20	ochoa	Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)]	[Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:34239127, ECO:0000303\|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:34516797, ECO:0000305\|PubMed:9582194}.
P62987	UBA52	S20	ochoa	Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)]	[Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:34239127, ECO:0000303\|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269\|PubMed:23169626, ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:32669547, ECO:0000269\|PubMed:39048817, ECO:0000269\|PubMed:39103523}.
Q09666	AHNAK	T590	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S613	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	T651	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S660	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	T718	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S781	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S793	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S1023	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S1042	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S1170	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S1298	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S1344	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	T1472	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S1542	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S1744	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S1802	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	T1885	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S2138	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	T2147	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S2423	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S2542	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S2600	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S2670	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S2926	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S2984	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S3054	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S3112	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S3240	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	T3625	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S3634	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S4092	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S4220	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S4360	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S4614	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S4803	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S4812	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S4870	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S5190	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S5293	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S5318	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S5620	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q8IVF2	AHNAK2	S1198	ochoa	Protein AHNAK2	None
Q8IVF2	AHNAK2	S2179	ochoa	Protein AHNAK2	None
Q8IVF2	AHNAK2	S4324	ochoa	Protein AHNAK2	None
Q8IVF2	AHNAK2	S4425	ochoa	Protein AHNAK2	None

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reactome_id	name	p	-log10_p
R-HSA-9706377	FLT3 signaling by CBL mutants	2.496114e-12	11.603
R-HSA-9683683	Maturation of protein E	4.257372e-12	11.371
R-HSA-9694493	Maturation of protein E	4.257372e-12	11.371
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	2.153577e-11	10.667
R-HSA-9828211	Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	1.520872e-11	10.818
R-HSA-8948747	Regulation of PTEN localization	1.038980e-11	10.983
R-HSA-3785653	Myoclonic epilepsy of Lafora	1.520872e-11	10.818
R-HSA-1253288	Downregulation of ERBB4 signaling	1.520872e-11	10.818
R-HSA-9637628	Modulation by Mtb of host immune system	1.520872e-11	10.818
R-HSA-8849469	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	1.520872e-11	10.818
R-HSA-9014325	TICAM1,TRAF6-dependent induction of TAK1 complex	2.965661e-11	10.528
R-HSA-5689877	Josephin domain DUBs	2.965661e-11	10.528
R-HSA-9664873	Pexophagy	2.965661e-11	10.528
R-HSA-9824878	Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	5.254619e-11	10.279
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	6.800949e-11	10.167
R-HSA-9645460	Alpha-protein kinase 1 signaling pathway	3.988176e-11	10.399
R-HSA-2691232	Constitutive Signaling by NOTCH1 HD Domain Mutants	6.800949e-11	10.167
R-HSA-2691230	Signaling by NOTCH1 HD Domain Mutants in Cancer	6.800949e-11	10.167
R-HSA-9013973	TICAM1-dependent activation of IRF3/IRF7	5.254619e-11	10.279
R-HSA-209560	NF-kB is activated and signals survival	5.254619e-11	10.279
R-HSA-937039	IRAK1 recruits IKK complex	6.800949e-11	10.167
R-HSA-8866427	VLDLR internalisation and degradation	6.800949e-11	10.167
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	6.800949e-11	10.167
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	3.988176e-11	10.399
R-HSA-209543	p75NTR recruits signalling complexes	6.800949e-11	10.167
R-HSA-937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	1.351590e-10	9.869
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	1.088947e-10	9.963
R-HSA-110312	Translesion synthesis by REV1	1.351590e-10	9.869
R-HSA-174490	Membrane binding and targetting of GAG proteins	8.665602e-11	10.062
R-HSA-174495	Synthesis And Processing Of GAG, GAGPOL Polyproteins	1.088947e-10	9.963
R-HSA-205043	NRIF signals cell death from the nucleus	1.088947e-10	9.963
R-HSA-8875360	InlB-mediated entry of Listeria monocytogenes into host cell	1.351590e-10	9.869
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	1.351590e-10	9.869
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	1.351590e-10	9.869
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	1.088947e-10	9.963
R-HSA-1295596	Spry regulation of FGF signaling	1.351590e-10	9.869
R-HSA-193639	p75NTR signals via NF-kB	1.351590e-10	9.869
R-HSA-5656121	Translesion synthesis by POLI	1.659067e-10	9.780
R-HSA-9758274	Regulation of NF-kappa B signaling	1.659067e-10	9.780
R-HSA-9708530	Regulation of BACH1 activity	1.659067e-10	9.780
R-HSA-9706369	Negative regulation of FLT3	1.659067e-10	9.780
R-HSA-5655862	Translesion synthesis by POLK	2.016206e-10	9.695
R-HSA-3134975	Regulation of innate immune responses to cytosolic DNA	2.016206e-10	9.695
R-HSA-936964	Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	2.016206e-10	9.695
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	2.016206e-10	9.695
R-HSA-4641263	Regulation of FZD by ubiquitination	2.428074e-10	9.615
R-HSA-3229121	Glycogen storage diseases	2.428074e-10	9.615
R-HSA-9613829	Chaperone Mediated Autophagy	2.899988e-10	9.538
R-HSA-6804760	Regulation of TP53 Activity through Methylation	2.899988e-10	9.538
R-HSA-110320	Translesion Synthesis by POLH	3.437506e-10	9.464
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	3.437506e-10	9.464
R-HSA-937041	IKK complex recruitment mediated by RIP1	3.437506e-10	9.464
R-HSA-912631	Regulation of signaling by CBL	3.437506e-10	9.464
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	5.502935e-10	9.259
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	4.732811e-10	9.325
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ...	4.732811e-10	9.325
R-HSA-8876384	Listeria monocytogenes entry into host cells	5.502935e-10	9.259
R-HSA-6807004	Negative regulation of MET activity	4.046431e-10	9.393
R-HSA-175474	Assembly Of The HIV Virion	5.502935e-10	9.259
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	5.502935e-10	9.259
R-HSA-9636383	Prevention of phagosomal-lysosomal fusion	4.732811e-10	9.325
R-HSA-2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	4.732811e-10	9.325
R-HSA-9931295	PD-L1(CD274) glycosylation and translocation to plasma membrane	4.732811e-10	9.325
R-HSA-9705462	Inactivation of CSF3 (G-CSF) signaling	5.502935e-10	9.259
R-HSA-3322077	Glycogen synthesis	4.046431e-10	9.393
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	4.732811e-10	9.325
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	4.732811e-10	9.325
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	6.363339e-10	9.196
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	6.363339e-10	9.196
R-HSA-9954716	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri...	6.493858e-10	9.187
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	8.382337e-10	9.077
R-HSA-5689901	Metalloprotease DUBs	1.084694e-09	8.965
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	1.084694e-09	8.965
R-HSA-9637687	Suppression of phagosomal maturation	1.084694e-09	8.965
R-HSA-1643713	Signaling by EGFR in Cancer	1.084694e-09	8.965
R-HSA-9692914	SARS-CoV-1-host interactions	1.161676e-09	8.935
R-HSA-8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	1.226525e-09	8.911
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	1.551387e-09	8.809
R-HSA-9615710	Late endosomal microautophagy	1.551387e-09	8.809
R-HSA-5656169	Termination of translesion DNA synthesis	1.551387e-09	8.809
R-HSA-901032	ER Quality Control Compartment (ERQC)	1.226525e-09	8.911
R-HSA-5654732	Negative regulation of FGFR3 signaling	1.381815e-09	8.860
R-HSA-5654733	Negative regulation of FGFR4 signaling	1.551387e-09	8.809
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway	1.226525e-09	8.911
R-HSA-5205685	PINK1-PRKN Mediated Mitophagy	1.381815e-09	8.860
R-HSA-9674555	Signaling by CSF3 (G-CSF)	1.551387e-09	8.809
R-HSA-8863795	Downregulation of ERBB2 signaling	1.736087e-09	8.760
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	1.936788e-09	8.713
R-HSA-162588	Budding and maturation of HIV virion	1.936788e-09	8.713
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	1.936788e-09	8.713
R-HSA-182971	EGFR downregulation	1.936788e-09	8.713
R-HSA-9833109	Evasion by RSV of host interferon responses	1.936788e-09	8.713
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	2.154384e-09	8.667
R-HSA-5675482	Regulation of necroptotic cell death	2.389795e-09	8.622
R-HSA-5654726	Negative regulation of FGFR1 signaling	2.389795e-09	8.622
R-HSA-5696394	DNA Damage Recognition in GG-NER	2.643965e-09	8.578
R-HSA-180534	Vpu mediated degradation of CD4	2.643965e-09	8.578
R-HSA-5696400	Dual Incision in GG-NER	2.917862e-09	8.535
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	2.917862e-09	8.535
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	2.917862e-09	8.535
R-HSA-168638	NOD1/2 Signaling Pathway	2.917862e-09	8.535
R-HSA-5654727	Negative regulation of FGFR2 signaling	2.917862e-09	8.535
R-HSA-901042	Calnexin/calreticulin cycle	2.917862e-09	8.535
R-HSA-1980145	Signaling by NOTCH2	2.917862e-09	8.535
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	2.917862e-09	8.535
R-HSA-5205647	Mitophagy	2.917862e-09	8.535
R-HSA-9948299	Ribosome-associated quality control	4.516708e-09	8.345
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	3.212477e-09	8.493
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	3.212477e-09	8.493
R-HSA-4641258	Degradation of DVL	3.867948e-09	8.413
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	3.528825e-09	8.452
R-HSA-180585	Vif-mediated degradation of APOBEC3G	3.528825e-09	8.452
R-HSA-5689896	Ovarian tumor domain proteases	3.867948e-09	8.413
R-HSA-4641257	Degradation of AXIN	3.867948e-09	8.413
R-HSA-9762114	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	3.867948e-09	8.413
R-HSA-9929356	GSK3B-mediated proteasomal degradation of PD-L1(CD274)	4.618791e-09	8.335
R-HSA-169911	Regulation of Apoptosis	3.212477e-09	8.493
R-HSA-69541	Stabilization of p53	4.618791e-09	8.335
R-HSA-5213460	RIPK1-mediated regulated necrosis	4.230907e-09	8.374
R-HSA-6804757	Regulation of TP53 Degradation	3.528825e-09	8.452
R-HSA-6806003	Regulation of TP53 Expression and Degradation	4.618791e-09	8.335
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	3.867948e-09	8.413
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	3.867948e-09	8.413
R-HSA-2559585	Oncogene Induced Senescence	3.212477e-09	8.493
R-HSA-9648002	RAS processing	4.618791e-09	8.335
R-HSA-8964043	Plasma lipoprotein clearance	4.618791e-09	8.335
R-HSA-9682385	FLT3 signaling in disease	3.528825e-09	8.452
R-HSA-9646399	Aggrephagy	5.032710e-09	8.298
R-HSA-5696395	Formation of Incision Complex in GG-NER	5.032710e-09	8.298
R-HSA-8941858	Regulation of RUNX3 expression and activity	5.032710e-09	8.298
R-HSA-9604323	Negative regulation of NOTCH4 signaling	5.032710e-09	8.298
R-HSA-8982491	Glycogen metabolism	5.032710e-09	8.298
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa...	5.473800e-09	8.262
R-HSA-9929491	SPOP-mediated proteasomal degradation of PD-L1(CD274)	5.473800e-09	8.262
R-HSA-5362768	Hh mutants are degraded by ERAD	5.473800e-09	8.262
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	5.473800e-09	8.262
R-HSA-9607240	FLT3 Signaling	5.473800e-09	8.262
R-HSA-9932298	Degradation of CRY and PER proteins	5.943220e-09	8.226
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	5.943220e-09	8.226
R-HSA-5610783	Degradation of GLI2 by the proteasome	5.943220e-09	8.226
R-HSA-5610780	Degradation of GLI1 by the proteasome	5.943220e-09	8.226
R-HSA-5675221	Negative regulation of MAPK pathway	5.943220e-09	8.226
R-HSA-9683701	Translation of Structural Proteins	5.943220e-09	8.226
R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	6.442153e-09	8.191
R-HSA-5387390	Hh mutants abrogate ligand secretion	6.971805e-09	8.157
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	6.971805e-09	8.157
R-HSA-5654743	Signaling by FGFR4	6.971805e-09	8.157
R-HSA-9637690	Response of Mtb to phagocytosis	6.971805e-09	8.157
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	7.151361e-09	8.146
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	7.533406e-09	8.123
R-HSA-69231	Cyclin D associated events in G1	7.533406e-09	8.123
R-HSA-69236	G1 Phase	7.533406e-09	8.123
R-HSA-6783310	Fanconi Anemia Pathway	8.128212e-09	8.090
R-HSA-5678895	Defective CFTR causes cystic fibrosis	8.128212e-09	8.090
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	8.128212e-09	8.090
R-HSA-69613	p53-Independent G1/S DNA Damage Checkpoint	8.128212e-09	8.090
R-HSA-69601	Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	8.128212e-09	8.090
R-HSA-4608870	Asymmetric localization of PCP proteins	8.128212e-09	8.090
R-HSA-5654741	Signaling by FGFR3	8.128212e-09	8.090
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	8.757498e-09	8.058
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	8.757498e-09	8.058
R-HSA-5357905	Regulation of TNFR1 signaling	8.757498e-09	8.058
R-HSA-9861718	Regulation of pyruvate metabolism	8.757498e-09	8.058
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	9.422568e-09	8.026
R-HSA-445989	TAK1-dependent IKK and NF-kappa-B activation	9.422568e-09	8.026
R-HSA-2467813	Separation of Sister Chromatids	1.003887e-08	7.998
R-HSA-73893	DNA Damage Bypass	1.086538e-08	7.964
R-HSA-9766229	Degradation of CDH1	1.086538e-08	7.964
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	1.086538e-08	7.964
R-HSA-69563	p53-Dependent G1 DNA Damage Response	1.086538e-08	7.964
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	1.086538e-08	7.964
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	1.086538e-08	7.964
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	1.333187e-08	7.875
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	1.724486e-08	7.763
R-HSA-6782135	Dual incision in TC-NER	1.949586e-08	7.710
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	1.333187e-08	7.875
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th...	1.424029e-08	7.846
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ...	1.424029e-08	7.846
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	1.619528e-08	7.791
R-HSA-9931269	AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	1.333187e-08	7.875
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	1.724486e-08	7.763
R-HSA-68949	Orc1 removal from chromatin	1.333187e-08	7.875
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	1.519426e-08	7.818
R-HSA-8948751	Regulation of PTEN stability and activity	1.424029e-08	7.846
R-HSA-9033241	Peroxisomal protein import	2.070043e-08	7.684
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	1.246753e-08	7.904
R-HSA-75893	TNF signaling	1.724486e-08	7.763
R-HSA-5658442	Regulation of RAS by GAPs	1.164584e-08	7.934
R-HSA-1169091	Activation of NF-kappaB in B cells	1.246753e-08	7.904
R-HSA-9764561	Regulation of CDH1 Function	1.834453e-08	7.736
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	1.724486e-08	7.763
R-HSA-2644603	Signaling by NOTCH1 in Cancer	2.195984e-08	7.658
R-HSA-1227986	Signaling by ERBB2	2.195984e-08	7.658
R-HSA-5358346	Hedgehog ligand biogenesis	1.246753e-08	7.904
R-HSA-9692916	SARS-CoV-1 activates/modulates innate immune responses	1.333187e-08	7.875
R-HSA-177929	Signaling by EGFR	1.724486e-08	7.763
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	2.195984e-08	7.658
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	2.195984e-08	7.658
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	2.195984e-08	7.658
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	2.195984e-08	7.658
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	2.070043e-08	7.684
R-HSA-5654736	Signaling by FGFR1	1.724486e-08	7.763
R-HSA-9012852	Signaling by NOTCH3	1.619528e-08	7.791
R-HSA-9678108	SARS-CoV-1 Infection	1.378860e-08	7.860
R-HSA-8939902	Regulation of RUNX2 expression and activity	2.327573e-08	7.633
R-HSA-450294	MAP kinase activation	2.327573e-08	7.633
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	2.464975e-08	7.608
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	2.464975e-08	7.608
R-HSA-69615	G1/S DNA Damage Checkpoints	2.608358e-08	7.584
R-HSA-8848021	Signaling by PTK6	2.608358e-08	7.584
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	2.608358e-08	7.584
R-HSA-376176	Signaling by ROBO receptors	2.693823e-08	7.570
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali...	2.757892e-08	7.559
R-HSA-1234174	Cellular response to hypoxia	2.913749e-08	7.536
R-HSA-5693606	DNA Double Strand Break Response	3.245134e-08	7.489
R-HSA-5685942	HDR through Homologous Recombination (HRR)	3.245134e-08	7.489
R-HSA-5218859	Regulated Necrosis	3.421018e-08	7.466
R-HSA-68882	Mitotic Anaphase	3.649301e-08	7.438
R-HSA-2555396	Mitotic Metaphase and Anaphase	3.726689e-08	7.429
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	3.794077e-08	7.421
R-HSA-195253	Degradation of beta-catenin by the destruction complex	3.794077e-08	7.421
R-HSA-448424	Interleukin-17 signaling	3.794077e-08	7.421
R-HSA-69202	Cyclin E associated events during G1/S transition	3.794077e-08	7.421
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	3.794077e-08	7.421
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	3.991623e-08	7.399
R-HSA-453276	Regulation of mitotic cell cycle	3.991623e-08	7.399
R-HSA-5632684	Hedgehog 'on' state	3.991623e-08	7.399
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	4.196764e-08	7.377
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	4.196764e-08	7.377
R-HSA-69052	Switching of origins to a post-replicative state	4.409690e-08	7.356
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	4.409690e-08	7.356
R-HSA-5663084	Diseases of carbohydrate metabolism	4.409690e-08	7.356
R-HSA-9013694	Signaling by NOTCH4	4.630595e-08	7.334
R-HSA-1236394	Signaling by ERBB4	4.630595e-08	7.334
R-HSA-9705683	SARS-CoV-2-host interactions	4.667553e-08	7.331
R-HSA-8852135	Protein ubiquitination	4.859674e-08	7.313
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	4.859674e-08	7.313
R-HSA-1169408	ISG15 antiviral mechanism	4.859674e-08	7.313
R-HSA-917937	Iron uptake and transport	4.859674e-08	7.313
R-HSA-5689603	UCH proteinases	5.097125e-08	7.293
R-HSA-1980143	Signaling by NOTCH1	5.097125e-08	7.293
R-HSA-9694635	Translation of Structural Proteins	5.343148e-08	7.272
R-HSA-5619084	ABC transporter disorders	5.597946e-08	7.252
R-HSA-4086400	PCP/CE pathway	5.597946e-08	7.252
R-HSA-5654738	Signaling by FGFR2	6.134686e-08	7.212
R-HSA-6806834	Signaling by MET	6.134686e-08	7.212
R-HSA-977225	Amyloid fiber formation	6.417044e-08	7.193
R-HSA-5693607	Processing of DNA double-strand break ends	6.417044e-08	7.193
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	6.709009e-08	7.173
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	7.010795e-08	7.154
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	7.322618e-08	7.135
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	7.322618e-08	7.135
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	7.322618e-08	7.135
R-HSA-5687128	MAPK6/MAPK4 signaling	7.644696e-08	7.117
R-HSA-9909615	Regulation of PD-L1(CD274) Post-translational modification	7.977249e-08	7.098
R-HSA-69620	Cell Cycle Checkpoints	8.222537e-08	7.085
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	8.320502e-08	7.080
R-HSA-70268	Pyruvate metabolism	8.674678e-08	7.062
R-HSA-9663891	Selective autophagy	9.040006e-08	7.044
R-HSA-1236974	ER-Phagosome pathway	9.416714e-08	7.026
R-HSA-202424	Downstream TCR signaling	9.805036e-08	7.009
R-HSA-9772573	Late SARS-CoV-2 Infection Events	1.104203e-07	6.957
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	1.104203e-07	6.957
R-HSA-68867	Assembly of the pre-replicative complex	1.147917e-07	6.940
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	1.239212e-07	6.907
R-HSA-9954709	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	1.286841e-07	6.890
R-HSA-5607764	CLEC7A (Dectin-1) signaling	1.335826e-07	6.874
R-HSA-170834	Signaling by TGF-beta Receptor Complex	1.386191e-07	6.858
R-HSA-8878159	Transcriptional regulation by RUNX3	1.386191e-07	6.858
R-HSA-975871	MyD88 cascade initiated on plasma membrane	1.437962e-07	6.842
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	1.437962e-07	6.842
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	1.437962e-07	6.842
R-HSA-190236	Signaling by FGFR	1.437962e-07	6.842
R-HSA-193704	p75 NTR receptor-mediated signalling	1.491164e-07	6.826
R-HSA-382556	ABC-family proteins mediated transport	1.545824e-07	6.811
R-HSA-5610787	Hedgehog 'off' state	1.545824e-07	6.811
R-HSA-9020702	Interleukin-1 signaling	1.601966e-07	6.795
R-HSA-2559580	Oxidative Stress Induced Senescence	1.659619e-07	6.780
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	1.779559e-07	6.750
R-HSA-9833110	RSV-host interactions	1.841901e-07	6.735
R-HSA-5696398	Nucleotide Excision Repair	1.905860e-07	6.720
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	1.905860e-07	6.720
R-HSA-69239	Synthesis of DNA	2.038741e-07	6.691
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	2.038741e-07	6.691
R-HSA-9700206	Signaling by ALK in cancer	2.038741e-07	6.691
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	2.107717e-07	6.676
R-HSA-1236975	Antigen processing-Cross presentation	2.107717e-07	6.676
R-HSA-2672351	Stimuli-sensing channels	2.107717e-07	6.676
R-HSA-975155	MyD88 dependent cascade initiated on endosome	2.178422e-07	6.662
R-HSA-69002	DNA Replication Pre-Initiation	2.178422e-07	6.662
R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	2.250884e-07	6.648
R-HSA-166166	MyD88-independent TLR4 cascade	2.250884e-07	6.648
R-HSA-202403	TCR signaling	2.250884e-07	6.648
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	2.479098e-07	6.606
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	2.558874e-07	6.592
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	2.724163e-07	6.565
R-HSA-909733	Interferon alpha/beta signaling	2.809734e-07	6.551
R-HSA-5693538	Homology Directed Repair	3.078519e-07	6.512
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	3.172238e-07	6.499
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	3.172238e-07	6.499
R-HSA-8878166	Transcriptional regulation by RUNX2	3.172238e-07	6.499
R-HSA-9694516	SARS-CoV-2 Infection	3.339487e-07	6.476
R-HSA-9635486	Infection with Mycobacterium tuberculosis	3.366051e-07	6.473
R-HSA-9759194	Nuclear events mediated by NFE2L2	3.366051e-07	6.473
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	3.466207e-07	6.460
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	3.466207e-07	6.460
R-HSA-162909	Host Interactions of HIV factors	3.673174e-07	6.435
R-HSA-69206	G1/S Transition	3.889230e-07	6.410
R-HSA-69481	G2/M Checkpoints	4.114634e-07	6.386
R-HSA-9909396	Circadian clock	4.849574e-07	6.314
R-HSA-68886	M Phase	5.161035e-07	6.287
R-HSA-3858494	Beta-catenin independent WNT signaling	5.533350e-07	6.257
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	5.678301e-07	6.246
R-HSA-5358351	Signaling by Hedgehog	5.826066e-07	6.235
R-HSA-6807070	PTEN Regulation	5.976682e-07	6.224
R-HSA-1632852	Macroautophagy	6.286607e-07	6.202
R-HSA-162599	Late Phase of HIV Life Cycle	6.608366e-07	6.180
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	6.608366e-07	6.180
R-HSA-8856828	Clathrin-mediated endocytosis	6.773775e-07	6.169
R-HSA-2871837	FCERI mediated NF-kB activation	6.942252e-07	6.158
R-HSA-453279	Mitotic G1 phase and G1/S transition	7.288562e-07	6.137
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	7.647597e-07	6.116
R-HSA-69242	S Phase	7.647597e-07	6.116
R-HSA-9755511	KEAP1-NFE2L2 pathway	8.210671e-07	6.086
R-HSA-446652	Interleukin-1 family signaling	8.405055e-07	6.075
R-HSA-9609507	Protein localization	8.602851e-07	6.065
R-HSA-69306	DNA Replication	8.602851e-07	6.065
R-HSA-5693532	DNA Double-Strand Break Repair	8.602851e-07	6.065
R-HSA-73887	Death Receptor Signaling	8.804096e-07	6.055
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	8.804096e-07	6.055
R-HSA-72766	Translation	8.892788e-07	6.051
R-HSA-9612973	Autophagy	9.217095e-07	6.035
R-HSA-162587	HIV Life Cycle	9.428928e-07	6.026
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	9.644369e-07	6.016
R-HSA-9006936	Signaling by TGFB family members	1.008624e-06	5.996
R-HSA-5633007	Regulation of TP53 Activity	1.008624e-06	5.996
R-HSA-109581	Apoptosis	1.054303e-06	5.977
R-HSA-5621481	C-type lectin receptors (CLRs)	1.306230e-06	5.884
R-HSA-9909648	Regulation of PD-L1(CD274) expression	1.333680e-06	5.875
R-HSA-5689880	Ub-specific processing proteases	1.361558e-06	5.866
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	1.361558e-06	5.866
R-HSA-9764265	Regulation of CDH1 Expression and Function	1.361558e-06	5.866
R-HSA-2559583	Cellular Senescence	1.569041e-06	5.804
R-HSA-201681	TCF dependent signaling in response to WNT	1.664816e-06	5.779
R-HSA-69275	G2/M Transition	1.764879e-06	5.753
R-HSA-2262752	Cellular responses to stress	1.803122e-06	5.744
R-HSA-453274	Mitotic G2-G2/M phases	1.834031e-06	5.737
R-HSA-983712	Ion channel transport	1.869354e-06	5.728
R-HSA-168898	Toll-like Receptor Cascades	1.941517e-06	5.712
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	2.130995e-06	5.671
R-HSA-389948	Co-inhibition by PD-1	2.292221e-06	5.640
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	2.418970e-06	5.616
R-HSA-5357801	Programmed Cell Death	2.550864e-06	5.593
R-HSA-422475	Axon guidance	2.748134e-06	5.561
R-HSA-9679506	SARS-CoV Infections	2.994847e-06	5.524
R-HSA-418990	Adherens junctions interactions	3.185163e-06	5.497
R-HSA-69278	Cell Cycle, Mitotic	3.286165e-06	5.483
R-HSA-8951664	Neddylation	3.346805e-06	5.475
R-HSA-8953897	Cellular responses to stimuli	3.550536e-06	5.450
R-HSA-8878171	Transcriptional regulation by RUNX1	3.629665e-06	5.440
R-HSA-162906	HIV Infection	3.688304e-06	5.433
R-HSA-9675108	Nervous system development	3.749510e-06	5.426
R-HSA-157118	Signaling by NOTCH	4.516457e-06	5.345
R-HSA-5619115	Disorders of transmembrane transporters	5.015779e-06	5.300
R-HSA-421270	Cell-cell junction organization	5.318893e-06	5.274
R-HSA-5688426	Deubiquitination	5.635410e-06	5.249
R-HSA-388841	Regulation of T cell activation by CD28 family	5.716678e-06	5.243
R-HSA-9711123	Cellular response to chemical stress	6.761279e-06	5.170
R-HSA-446728	Cell junction organization	7.734813e-06	5.112
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	8.151974e-06	5.089
R-HSA-5673001	RAF/MAP kinase cascade	8.921887e-06	5.050
R-HSA-1640170	Cell Cycle	9.489547e-06	5.023
R-HSA-1257604	PIP3 activates AKT signaling	9.623656e-06	5.017
R-HSA-5684996	MAPK1/MAPK3 signaling	9.744481e-06	5.011
R-HSA-195721	Signaling by WNT	9.989502e-06	5.000
R-HSA-156902	Peptide chain elongation	1.196620e-05	4.922
R-HSA-1500931	Cell-Cell communication	1.240557e-05	4.906
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	1.310197e-05	4.883
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	1.349582e-05	4.870
R-HSA-156842	Eukaryotic Translation Elongation	1.389742e-05	4.857
R-HSA-72689	Formation of a pool of free 40S subunits	1.558279e-05	4.807
R-HSA-72764	Eukaryotic Translation Termination	1.558279e-05	4.807
R-HSA-1428517	Aerobic respiration and respiratory electron transport	1.644742e-05	4.784
R-HSA-9006925	Intracellular signaling by second messengers	1.662706e-05	4.779
R-HSA-5683057	MAPK family signaling cascades	1.754717e-05	4.756
R-HSA-2408557	Selenocysteine synthesis	1.835578e-05	4.736
R-HSA-192823	Viral mRNA Translation	1.934774e-05	4.713
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	1.985672e-05	4.702
R-HSA-73894	DNA Repair	2.011578e-05	4.696
R-HSA-8953854	Metabolism of RNA	2.075250e-05	4.683
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	2.198107e-05	4.658
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	2.253461e-05	4.647
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	2.253461e-05	4.647
R-HSA-927802	Nonsense-Mediated Decay (NMD)	2.484078e-05	4.605
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	2.484078e-05	4.605
R-HSA-983169	Class I MHC mediated antigen processing & presentation	2.557530e-05	4.592
R-HSA-913531	Interferon Signaling	2.557530e-05	4.592
R-HSA-9824439	Bacterial Infection Pathways	2.735569e-05	4.563
R-HSA-72613	Eukaryotic Translation Initiation	2.858385e-05	4.544
R-HSA-72737	Cap-dependent Translation Initiation	2.858385e-05	4.544
R-HSA-446203	Asparagine N-linked glycosylation	3.668441e-05	4.436
R-HSA-5668914	Diseases of metabolism	3.832999e-05	4.416
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	4.857230e-05	4.314
R-HSA-3700989	Transcriptional Regulation by TP53	5.267743e-05	4.278
R-HSA-168273	Influenza Viral RNA Transcription and Replication	6.668952e-05	4.176
R-HSA-9711097	Cellular response to starvation	7.017009e-05	4.154
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	7.714823e-05	4.113
R-HSA-2408522	Selenoamino acid metabolism	7.748501e-05	4.111
R-HSA-9824446	Viral Infection Pathways	8.584495e-05	4.066
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	8.663163e-05	4.062
R-HSA-168255	Influenza Infection	9.939634e-05	4.003
R-HSA-8868773	rRNA processing in the nucleus and cytosol	1.133364e-04	3.946
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	1.480290e-04	3.830
R-HSA-449147	Signaling by Interleukins	1.591676e-04	3.798
R-HSA-9735869	SARS-CoV-1 modulates host translation machinery	1.796750e-04	3.746
R-HSA-199991	Membrane Trafficking	1.822158e-04	3.739
R-HSA-72312	rRNA processing	2.023359e-04	3.694
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	3.106734e-04	3.508
R-HSA-72649	Translation initiation complex formation	4.087296e-04	3.389
R-HSA-9754678	SARS-CoV-2 modulates host translation machinery	4.087296e-04	3.389
R-HSA-5653656	Vesicle-mediated transport	4.157479e-04	3.381
R-HSA-72702	Ribosomal scanning and start codon recognition	4.353081e-04	3.361
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub...	4.627098e-04	3.335
R-HSA-5663205	Infectious disease	5.763139e-04	3.239
R-HSA-382551	Transport of small molecules	8.561293e-04	3.067
R-HSA-1280218	Adaptive Immune System	1.086063e-03	2.964
R-HSA-1266738	Developmental Biology	1.107430e-03	2.956
R-HSA-1280215	Cytokine Signaling in Immune system	1.197622e-03	2.922
R-HSA-168249	Innate Immune System	2.622841e-03	2.581
R-HSA-392499	Metabolism of proteins	2.933356e-03	2.533
R-HSA-71291	Metabolism of amino acids and derivatives	3.010488e-03	2.521
R-HSA-212436	Generic Transcription Pathway	4.611282e-03	2.336
R-HSA-597592	Post-translational protein modification	5.864350e-03	2.232
R-HSA-1643685	Disease	6.079085e-03	2.216
R-HSA-73857	RNA Polymerase II Transcription	6.320954e-03	2.199
R-HSA-162582	Signal Transduction	8.166367e-03	2.088
R-HSA-74160	Gene expression (Transcription)	1.079869e-02	1.967
R-HSA-1430728	Metabolism	2.050412e-02	1.688
R-HSA-3371511	HSF1 activation	2.116389e-02	1.674
R-HSA-3371568	Attenuation phase	2.311255e-02	1.636
R-HSA-3371571	HSF1-dependent transactivation	2.893817e-02	1.539
R-HSA-168256	Immune System	3.508596e-02	1.455
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	4.575632e-02	1.340
R-HSA-141424	Amplification of signal from the kinetochores	4.575632e-02	1.340
R-HSA-69618	Mitotic Spindle Checkpoint	5.383276e-02	1.269
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	5.477899e-02	1.261
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	5.855562e-02	1.232
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	6.513296e-02	1.186
R-HSA-3371556	Cellular response to heat stress	6.513296e-02	1.186
R-HSA-68877	Mitotic Prometaphase	1.005946e-01	0.997

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
TGFBR2	0.517	0.226	-2	0.608
DSTYK	0.512	0.134	2	0.299
NEK6	0.512	0.187	-2	0.529
IKKE	0.506	0.078	1	0.563
NEK7	0.506	0.135	-3	0.533
ACVR2A	0.501	0.193	-2	0.607
IKKB	0.501	-0.001	-2	0.240
BMPR2	0.500	0.210	-2	0.434
BMPR1B	0.500	0.084	1	0.354
FAM20C	0.500	0.048	2	0.336
COT	0.499	0.055	2	0.266
TBK1	0.499	0.032	1	0.552
ACVR2B	0.499	0.175	-2	0.587
TGFBR1	0.497	0.057	-2	0.458
IKKA	0.497	0.003	-2	0.263
PLK1	0.497	0.161	-2	0.603
ULK2	0.497	0.012	2	0.201
CDK3	0.494	0.123	1	0.313
KIS	0.494	0.066	1	0.411
PERK	0.494	0.191	-2	0.538
CDC7	0.491	0.013	1	0.404
ALK4	0.491	0.064	-2	0.451
PDHK1	0.491	-0.052	1	0.557
GCN2	0.491	0.038	2	0.216
CLK3	0.491	0.064	1	0.434
PLK4	0.490	0.057	2	0.145
ALK2	0.490	0.058	-2	0.473
MARK4	0.490	-0.037	4	0.537
PLK3	0.489	0.054	2	0.260
CHAK2	0.489	0.067	-1	0.318
BMPR1A	0.488	0.068	1	0.340
HRI	0.488	0.165	-2	0.536
ERK5	0.488	-0.034	1	0.517
PRPK	0.488	-0.111	-1	0.393
PIM3	0.488	-0.001	-3	0.356
NLK	0.487	-0.023	1	0.478
TLK2	0.487	0.066	1	0.429
MOS	0.487	-0.009	1	0.463
CDK1	0.485	0.059	1	0.319
GRK1	0.485	-0.038	-2	0.282
RAF1	0.485	-0.052	1	0.525
PRKD1	0.484	-0.023	-3	0.384
MTOR	0.484	-0.072	1	0.462
CDK2	0.484	0.114	1	0.364
SRPK1	0.484	0.007	-3	0.329
CAMK2G	0.484	-0.086	2	0.281
NEK9	0.484	-0.039	2	0.224
GRK7	0.484	0.065	1	0.349
PDHK4	0.483	-0.166	1	0.509
MLK1	0.482	-0.038	2	0.212
ATR	0.482	-0.068	1	0.413
GRK4	0.482	-0.019	-2	0.417
ULK1	0.482	-0.050	-3	0.515
MPSK1	0.481	0.079	1	0.565
ANKRD3	0.481	0.002	1	0.512
MARK2	0.481	-0.030	4	0.557
TTBK2	0.480	-0.045	2	0.173
TSSK1	0.480	-0.050	-3	0.409
SMG1	0.479	-0.045	1	0.397
HIPK4	0.479	-0.012	1	0.401
SRPK3	0.478	0.025	-3	0.319
YSK4	0.478	-0.013	1	0.501
TSSK2	0.478	-0.072	-5	0.540
P38D	0.478	-0.001	1	0.348
CDK5	0.477	0.019	1	0.389
QSK	0.477	-0.039	4	0.533
GRK5	0.476	-0.091	-3	0.481
MARK3	0.476	-0.040	4	0.522
MASTL	0.475	-0.158	-2	0.314
PKR	0.475	0.007	1	0.490
BCKDK	0.475	-0.109	-1	0.299
MLK3	0.475	-0.020	2	0.185
PINK1	0.475	-0.013	1	0.486
P38B	0.475	-0.023	1	0.389
SKMLCK	0.475	-0.091	-2	0.267
MEK1	0.474	-0.065	2	0.282
MST4	0.474	-0.025	2	0.283
NEK2	0.474	-0.064	2	0.237
CAMLCK	0.473	-0.087	-2	0.278
CDKL5	0.473	-0.046	-3	0.394
PIM1	0.473	-0.025	-3	0.295
ATM	0.473	-0.045	1	0.344
MLK2	0.473	-0.089	2	0.243
HUNK	0.472	-0.152	2	0.236
VRK2	0.472	-0.082	1	0.501
CDK8	0.472	-0.048	1	0.389
SRPK2	0.472	0.007	-3	0.262
PLK2	0.472	0.015	-3	0.346
TTBK1	0.472	-0.043	2	0.142
CDKL1	0.471	-0.067	-3	0.396
CAMK2D	0.471	-0.125	-3	0.427
TLK1	0.471	0.038	-2	0.527
CAMK1B	0.471	-0.128	-3	0.428
PRKD2	0.470	-0.039	-3	0.322
DAPK2	0.470	-0.095	-3	0.449
WNK3	0.470	-0.131	1	0.493
AMPKA1	0.470	-0.080	-3	0.391
PRP4	0.470	-0.019	-3	0.411
DNAPK	0.469	-0.053	1	0.416
MLK4	0.469	-0.029	2	0.160
NIK	0.469	-0.148	-3	0.440
WNK1	0.469	-0.122	-2	0.240
CHAK1	0.468	-0.018	2	0.279
JNK2	0.468	-0.028	1	0.355
NIM1	0.468	-0.097	3	0.432
RIPK3	0.468	-0.137	3	0.396
NEK5	0.468	-0.032	1	0.501
JNK3	0.468	-0.035	1	0.365
BIKE	0.468	0.148	1	0.665
LATS1	0.468	-0.011	-3	0.377
NUAK2	0.467	-0.088	-3	0.387
AAK1	0.467	0.161	1	0.658
IRE1	0.466	-0.082	1	0.445
PKCD	0.466	-0.070	2	0.201
ICK	0.466	-0.077	-3	0.414
IRE2	0.466	-0.061	2	0.163
AURC	0.466	-0.037	-2	0.160
PKN3	0.466	-0.118	-3	0.407
MARK1	0.465	-0.074	4	0.516
CDK7	0.465	-0.035	1	0.385
GRK6	0.464	-0.126	1	0.411
ERK1	0.464	-0.043	1	0.392
CLK1	0.464	-0.020	-3	0.307
CDK19	0.464	-0.053	1	0.377
GAK	0.464	0.073	1	0.612
CDK13	0.464	-0.049	1	0.370
MEKK1	0.464	-0.072	1	0.514
CAMKK1	0.463	-0.051	-2	0.238
PAK6	0.463	-0.068	-2	0.150
PBK	0.463	0.099	1	0.670
P38A	0.463	-0.054	1	0.432
CLK4	0.463	-0.035	-3	0.308
SSTK	0.463	-0.069	4	0.532
TTK	0.463	0.214	-2	0.632
MEKK2	0.463	-0.030	2	0.206
AURB	0.462	-0.053	-2	0.167
DLK	0.462	-0.171	1	0.439
NDR2	0.462	-0.114	-3	0.364
RSK2	0.462	-0.082	-3	0.336
CK2A2	0.462	-0.017	1	0.342
CAMK2B	0.462	-0.109	2	0.295
MEK2	0.462	-0.022	2	0.245
PKG2	0.461	-0.063	-2	0.159
AMPKA2	0.461	-0.091	-3	0.357
TNIK	0.461	0.073	3	0.612
QIK	0.461	-0.125	-3	0.437
P38G	0.461	-0.036	1	0.298
RSK3	0.460	-0.080	-3	0.335
PKCA	0.460	-0.076	2	0.172
ERK7	0.460	-0.034	2	0.115
MST2	0.460	0.005	1	0.529
MINK	0.460	0.061	1	0.553
SIK	0.460	-0.075	-3	0.312
HGK	0.460	0.034	3	0.581
PRKD3	0.459	-0.068	-3	0.324
RIPK1	0.459	-0.195	1	0.434
BRSK2	0.459	-0.098	-3	0.366
CDK6	0.459	-0.005	1	0.390
DYRK2	0.459	-0.076	1	0.382
IRAK1	0.458	-0.131	-1	0.371
PIM2	0.458	-0.040	-3	0.323
LATS2	0.458	-0.103	-5	0.400
ZAK	0.458	-0.091	1	0.460
AURA	0.458	-0.062	-2	0.178
CLK2	0.457	-0.023	-3	0.268
CHK1	0.457	-0.120	-3	0.347
BUB1	0.457	0.019	-5	0.501
JNK1	0.457	-0.036	1	0.327
CDK12	0.457	-0.056	1	0.351
PAK3	0.457	-0.116	-2	0.196
PKN2	0.457	-0.130	-3	0.397
MAPKAPK3	0.456	-0.111	-3	0.319
MEKK3	0.456	-0.096	1	0.477
TAO3	0.456	-0.013	1	0.475
IRAK4	0.456	-0.101	1	0.473
P90RSK	0.456	-0.106	-3	0.339
BRSK1	0.455	-0.100	-3	0.333
NDR1	0.455	-0.128	-3	0.358
NEK4	0.455	-0.060	1	0.535
TAK1	0.455	-0.017	1	0.471
PAK1	0.455	-0.106	-2	0.200
CAMKK2	0.455	-0.070	-2	0.211
NEK8	0.455	-0.047	2	0.218
GSK3B	0.455	-0.054	4	0.130
LKB1	0.454	-0.048	-3	0.484
GRK2	0.454	-0.093	-2	0.298
BRAF	0.454	-0.117	-4	0.508
PKACG	0.453	-0.108	-2	0.204
MAPKAPK2	0.453	-0.079	-3	0.255
MST1	0.453	0.020	1	0.533
CDK9	0.453	-0.072	1	0.382
PAK2	0.453	-0.121	-2	0.199
NUAK1	0.453	-0.097	-3	0.332
CAMK2A	0.453	-0.118	2	0.297
MELK	0.453	-0.125	-3	0.355
MAK	0.452	-0.024	-2	0.155
MEK5	0.452	-0.169	2	0.242
GRK3	0.452	-0.080	-2	0.295
PHKG1	0.452	-0.105	-3	0.342
PKCZ	0.452	-0.104	2	0.201
EEF2K	0.451	0.000	3	0.632
MNK2	0.451	-0.106	-2	0.219
CDK18	0.451	-0.056	1	0.347
PKCB	0.451	-0.095	2	0.171
CK2A1	0.451	-0.040	1	0.320
CK1G1	0.450	-0.062	-3	0.173
WNK4	0.450	-0.146	-2	0.259
P70S6KB	0.450	-0.114	-3	0.351
ERK2	0.450	-0.074	1	0.375
GSK3A	0.450	-0.055	4	0.134
GCK	0.449	-0.003	1	0.523
NEK1	0.449	-0.079	1	0.494
MST3	0.449	-0.085	2	0.263
PKACB	0.448	-0.072	-2	0.185
CDK17	0.448	-0.057	1	0.296
TAO2	0.448	-0.068	2	0.256
CK1D	0.448	-0.067	-3	0.170
PKCG	0.448	-0.118	2	0.174
KHS1	0.448	0.006	1	0.566
PKCH	0.447	-0.121	2	0.149
LOK	0.447	-0.042	-2	0.242
DYRK1A	0.447	-0.075	1	0.400
NEK3	0.447	-0.089	1	0.504
DYRK4	0.447	-0.073	1	0.343
HIPK3	0.446	-0.080	1	0.429
MYLK4	0.446	-0.120	-2	0.213
PDK1	0.446	-0.110	1	0.459
KHS2	0.446	0.017	1	0.554
SGK3	0.446	-0.111	-3	0.337
MSK1	0.446	-0.110	-3	0.310
STK33	0.445	-0.096	2	0.155
HIPK1	0.445	-0.069	1	0.408
VRK1	0.445	-0.097	2	0.224
HIPK2	0.445	-0.049	1	0.330
OSR1	0.444	0.014	2	0.225
DCAMKL1	0.444	-0.118	-3	0.298
NEK11	0.443	-0.134	1	0.480
AKT2	0.443	-0.076	-3	0.275
DYRK1B	0.443	-0.064	1	0.372
SNRK	0.443	-0.180	2	0.165
HPK1	0.442	-0.040	1	0.534
RIPK2	0.442	-0.146	1	0.459
RSK4	0.441	-0.105	-3	0.297
CAMK4	0.441	-0.188	-3	0.359
CDK4	0.441	-0.051	1	0.346
MSK2	0.441	-0.132	-3	0.305
MEKK6	0.441	-0.128	1	0.496
PAK4	0.441	-0.089	-2	0.151
DRAK1	0.441	-0.162	1	0.300
PKACA	0.441	-0.078	-2	0.149
MAPKAPK5	0.441	-0.133	-3	0.319
PAK5	0.440	-0.097	-2	0.142
PKCT	0.440	-0.119	2	0.152
DCAMKL2	0.440	-0.122	-3	0.336
MNK1	0.440	-0.122	-2	0.226
PKCI	0.440	-0.102	2	0.174
SLK	0.439	-0.050	-2	0.239
PRKX	0.439	-0.062	-3	0.224
MYO3B	0.439	-0.015	2	0.262
SMMLCK	0.437	-0.134	-3	0.408
MAP3K15	0.437	-0.138	1	0.465
CDK14	0.437	-0.083	1	0.386
MYO3A	0.437	0.009	1	0.507
PKCE	0.436	-0.081	2	0.171
DYRK3	0.436	-0.095	1	0.409
YSK1	0.436	-0.097	2	0.215
PASK	0.436	-0.141	-3	0.413
CK1E	0.435	-0.107	-3	0.191
PKG1	0.434	-0.084	-2	0.115
LRRK2	0.434	-0.148	2	0.254
CDK16	0.434	-0.070	1	0.310
PHKG2	0.434	-0.122	-3	0.360
CK1A2	0.434	-0.092	-3	0.160
AKT1	0.433	-0.091	-3	0.280
YANK3	0.433	-0.069	2	0.117
DAPK3	0.432	-0.104	-3	0.327
P70S6K	0.432	-0.109	-3	0.313
MRCKB	0.431	-0.089	-3	0.311
MOK	0.431	-0.071	1	0.424
AKT3	0.430	-0.071	-3	0.219
CDK10	0.430	-0.071	1	0.370
ROCK2	0.429	-0.093	-3	0.319
TAO1	0.429	-0.055	1	0.477
CAMK1G	0.429	-0.152	-3	0.337
MRCKA	0.428	-0.087	-3	0.298
CAMK1D	0.428	-0.127	-3	0.237
CHK2	0.427	-0.090	-3	0.224
PKN1	0.427	-0.119	-3	0.323
SGK1	0.426	-0.081	-3	0.205
STLK3	0.424	-0.081	1	0.454
SBK	0.423	-0.092	-3	0.186
ASK1	0.422	-0.138	1	0.453
LCK	0.422	0.187	-1	0.543
BLK	0.421	0.174	-1	0.532
DAPK1	0.421	-0.129	-3	0.331
CK1G3	0.418	-0.064	-3	0.082
HCK	0.418	0.144	-1	0.542
CAMK1A	0.417	-0.123	-3	0.231
CK1A	0.416	-0.083	-3	0.103
DMPK1	0.416	-0.095	-3	0.308
TXK	0.416	0.118	1	0.440
HASPIN	0.415	-0.086	-1	0.231
ALPHAK3	0.415	-0.052	-1	0.288
FYN	0.413	0.118	-1	0.544
ROCK1	0.413	-0.109	-3	0.295
YES1	0.412	0.124	-1	0.592
LYN	0.411	0.104	3	0.372
SRC	0.410	0.116	-1	0.596
BTK	0.408	0.064	-1	0.532
CRIK	0.408	-0.097	-3	0.294
FGR	0.406	0.074	1	0.533
TEC	0.406	0.072	-1	0.567
YANK2	0.405	-0.087	2	0.120
PTK6	0.405	0.049	-1	0.492
JAK1	0.405	0.083	1	0.493
ITK	0.404	0.055	-1	0.488
PDHK3_TYR	0.404	0.017	4	0.439
SRMS	0.404	0.030	1	0.444
ABL2	0.403	0.050	-1	0.474
ABL1	0.402	0.048	-1	0.513
FER	0.401	-0.003	1	0.473
JAK2	0.400	0.012	1	0.496
PTK2B	0.400	0.058	-1	0.621
MAP2K4_TYR	0.399	-0.013	-1	0.369
BMX	0.399	0.018	-1	0.452
EPHB2	0.399	0.017	-1	0.440
TYK2	0.399	-0.002	1	0.500
EPHA6	0.398	-0.005	-1	0.395
PKMYT1_TYR	0.397	-0.028	3	0.494
TYRO3	0.397	-0.018	3	0.460
ROS1	0.396	0.003	3	0.426
EPHB3	0.396	-0.027	-1	0.436
EPHB4	0.395	-0.030	-1	0.417
TNK2	0.395	0.001	3	0.376
CK1G2	0.394	-0.091	-3	0.129
MERTK	0.394	-0.020	3	0.361
EPHA4	0.393	-0.032	2	0.289
TNNI3K_TYR	0.393	-0.008	1	0.533
EPHB1	0.393	-0.032	1	0.454
CSF1R	0.393	-0.016	3	0.414
FRK	0.392	0.012	-1	0.528
MAP2K6_TYR	0.392	-0.069	-1	0.328
PDHK1_TYR	0.391	-0.069	-1	0.374
MAP2K7_TYR	0.391	-0.195	2	0.288
TESK1_TYR	0.391	-0.106	3	0.543
RET	0.391	-0.071	1	0.472
BMPR2_TYR	0.390	-0.063	-1	0.311
AXL	0.389	-0.052	3	0.382
NEK10_TYR	0.389	0.006	1	0.411
MST1R	0.389	-0.047	3	0.437
ALK	0.388	-0.013	3	0.371
FLT3	0.387	-0.007	3	0.434
EPHA1	0.387	-0.037	3	0.358
KIT	0.387	-0.024	3	0.418
LIMK2_TYR	0.386	-0.080	-3	0.481
LTK	0.386	-0.034	3	0.376
EPHA7	0.385	-0.049	2	0.269
TEK	0.385	-0.066	3	0.383
PDHK4_TYR	0.384	-0.133	2	0.325
FGFR4	0.383	-0.030	-1	0.389
WEE1_TYR	0.382	-0.043	-1	0.375
LIMK1_TYR	0.382	-0.116	2	0.273
EPHA8	0.382	-0.033	-1	0.398
EPHA3	0.381	-0.070	2	0.257
PINK1_TYR	0.381	-0.163	1	0.438
NTRK3	0.381	-0.055	-1	0.362
DDR1	0.381	-0.131	4	0.427
FGFR1	0.381	-0.076	3	0.386
PDGFRB	0.381	-0.073	3	0.450
FES	0.379	-0.024	-1	0.492
NTRK2	0.379	-0.065	3	0.396
PDGFRA	0.379	-0.070	3	0.462
EGFR	0.379	-0.035	1	0.337
ERBB2	0.379	-0.065	1	0.420
INSRR	0.378	-0.065	3	0.383
EPHA5	0.377	-0.069	2	0.274
MATK	0.376	-0.051	-1	0.395
CSK	0.376	-0.065	2	0.262
INSR	0.376	-0.065	3	0.372
NTRK1	0.376	-0.103	-1	0.382
TNK1	0.375	-0.109	3	0.418
MET	0.375	-0.049	3	0.396
JAK3	0.374	-0.103	1	0.419
FGFR2	0.373	-0.130	3	0.395
EPHA2	0.371	-0.071	-1	0.342
PTK2	0.371	-0.053	-1	0.278
FGFR3	0.367	-0.118	3	0.378
IGF1R	0.367	-0.069	3	0.327
SYK	0.367	-0.056	-1	0.283
KDR	0.367	-0.123	3	0.375
ERBB4	0.365	-0.052	1	0.343
DDR2	0.364	-0.106	3	0.375
MUSK	0.364	-0.074	1	0.352
FLT1	0.363	-0.108	-1	0.302
FLT4	0.357	-0.149	3	0.374
ZAP70	0.350	-0.058	-1	0.217