Motif 690 (n=88)

Position-wise Probabilities
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uniprot genes site source protein function
O60701 UGDH S381 ochoa UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}.
O60841 EIF5B S295 ochoa Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}.
P04049 RAF1 S494 ochoa|psp RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P14625 HSP90B1 S674 psp Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}.
P15056 BRAF S602 ochoa|psp Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.
P17844 DDX5 S402 ochoa Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}.
P18583 SON S152 ochoa Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.
P23497 SP100 S228 ochoa Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}.
P25705 ATP5F1A S413 ochoa ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}.
P30414 NKTR S887 ochoa NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}.
P31415 CASQ1 S128 ochoa Calsequestrin-1 (Calmitine) (Calsequestrin, skeletal muscle isoform) Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:28895244). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (PubMed:28895244). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (PubMed:27185316). {ECO:0000269|PubMed:22337878, ECO:0000269|PubMed:27185316, ECO:0000269|PubMed:28895244, ECO:0000303|PubMed:22337878}.
P33981 TTK S37 ochoa|psp Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}.
P33981 TTK S742 psp Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}.
P42345 MTOR S2478 ochoa Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}.
P43307 SSR1 S246 ochoa Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
P46013 MKI67 S171 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46821 MAP1B S1939 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P55010 EIF5 S410 ochoa Eukaryotic translation initiation factor 5 (eIF-5) Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}.
P61604 HSPE1 S51 ochoa 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1) Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131, PubMed:7912672). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}.
Q00403 GTF2B S70 ochoa Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}.
Q01064 PDE1B S466 ochoa Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE) Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15260978, PubMed:8855339, PubMed:9419816). Has a preference for cGMP as a substrate (PubMed:9419816). {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:8855339, ECO:0000269|PubMed:9419816}.
Q03164 KMT2A S2315 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q08050 FOXM1 S730 ochoa|psp Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}.
Q08J23 NSUN2 S721 ochoa RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}.
Q09666 AHNAK T590 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK T718 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S1344 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK T1472 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S1802 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S2138 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S2600 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S2984 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S3112 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S3240 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S4614 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S4803 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S4870 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S5318 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S5418 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S5573 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S5620 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q13206 DDX10 S606 ochoa Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599). {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:36779599}.
Q13573 SNW1 S92 ochoa SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}.
Q14151 SAFB2 S226 ochoa Scaffold attachment factor B2 (SAF-B2) Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q15424 SAFB S227 ochoa Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}.
Q15464 SHB S247 ochoa SH2 domain-containing adapter protein B Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}.
Q16513 PKN2 S110 ochoa Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}.
Q5JSH3 WDR44 S195 ochoa WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}.
Q641Q2 WASHC2A S877 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q6P4F7 ARHGAP11A S604 ochoa Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}.
Q6P995 FAM171B S503 ochoa Protein FAM171B None
Q6ZNL6 FGD5 S740 ochoa FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}.
Q7L2Z9 CENPQ S31 ochoa Centromere protein Q (CENP-Q) Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}.
Q7Z2E3 APTX S177 ochoa Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15044383, PubMed:15380105, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). {ECO:0000250|UniProtKB:O74859, ECO:0000269|PubMed:15044383, ECO:0000269|PubMed:15380105, ECO:0000269|PubMed:16547001, ECO:0000269|PubMed:16964241, ECO:0000269|PubMed:17276982, ECO:0000269|PubMed:24362567}.
Q7Z5N4 SDK1 S2115 ochoa Protein sidekick-1 Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q8AV58}.
Q7Z6I6 ARHGAP30 S330 ochoa Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}.
Q86YP4 GATAD2A S38 ochoa Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.
Q8IVF2 AHNAK2 S2179 ochoa Protein AHNAK2 None
Q8IVF2 AHNAK2 S4324 ochoa Protein AHNAK2 None
Q8IVF2 AHNAK2 S4425 ochoa Protein AHNAK2 None
Q8IY81 FTSJ3 S333 ochoa pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}.
Q8N1G2 CMTR1 S26 ochoa Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}.
Q8NEV8 EXPH5 S940 ochoa Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) May act as Rab effector protein and play a role in vesicle trafficking.
Q8TEV9 SMCR8 S421 ochoa Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}.
Q8WXW3 PIBF1 S700 ochoa Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90) Plays a role in ciliogenesis. {ECO:0000269|PubMed:26167768}.; FUNCTION: [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211, ECO:0000269|PubMed:26297806}.; FUNCTION: [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual natural killer cells (NK) activity exerts an anti-abortive effect (PubMed:12516630, PubMed:14634107, PubMed:3863495). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441). {ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:16393965, ECO:0000269|PubMed:25218441, ECO:0000269|PubMed:3863495, ECO:0000305|PubMed:11407300}.
Q92841 DDX17 S479 ochoa Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:22266867, PubMed:26209609). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:19995069, PubMed:20663877). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:19995069, PubMed:20406972, PubMed:20663877, PubMed:24275493). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). {ECO:0000250|UniProtKB:Q501J6, ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17485482, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:18334637, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:20406972, ECO:0000269|PubMed:20663877, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:24275493, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:24910439, ECO:0000269|PubMed:25126784, ECO:0000269|PubMed:26209609, ECO:0000269|PubMed:27478153, ECO:0000305}.
Q96T37 RBM15 S257 ochoa RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}.
Q96T58 SPEN S1629 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99549 MPHOSPH8 S264 ochoa M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}.
Q99590 SCAF11 S533 ochoa Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}.
Q99808 SLC29A1 S266 ochoa Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}.
Q9BZC7 ABCA2 S1331 ochoa ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}.
Q9H0E3 SAP130 S875 ochoa Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}.
Q9NR50 EIF2B3 S428 ochoa Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}.
Q9P2D0 IBTK S1195 ochoa Inhibitor of Bruton tyrosine kinase (IBtk) Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}.
Q9UMD9 COL17A1 S400 ochoa Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.
Q9UNY4 TTF2 S268 ochoa Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}.
Q9UPZ3 HPS5 S665 ochoa BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}.
Q9UQ35 SRRM2 S142 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2L6 FRMD4B S372 ochoa FERM domain-containing protein 4B (GRP1-binding protein GRSP1) Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}.
S4R3N1 HSPE1-MOB4 S51 ochoa 10 kDa heat shock protein, mitochondrial (10 kDa chaperonin) (Chaperonin 10) (MOB-like protein phocein) (Mob1 homolog 3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3) Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. {ECO:0000256|ARBA:ARBA00046093}.; FUNCTION: Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000256|ARBA:ARBA00044741}.
Q15648 MED1 S932 Sugiyama Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
P61769 B2M S72 Sugiyama Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}.
P10721 KIT S715 Sugiyama Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}.
O95359 TACC2 S2270 Sugiyama Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.
O76070 SNCG S51 Sugiyama Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}.
Q86WR0 CCDC25 S188 Sugiyama Coiled-coil domain-containing protein 25 Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174). {ECO:0000269|PubMed:32528174}.
Q9Y4K4 MAP4K5 S60 Sugiyama Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}.
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reactome_id name p -log10_p
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 0.001180 2.928
R-HSA-9660537 Signaling by MRAS-complex mutants 0.001423 2.847
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 0.001423 2.847
R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.000760 3.119
R-HSA-877300 Interferon gamma signaling 0.000264 3.578
R-HSA-9669937 Drug resistance of KIT mutants 0.004956 2.305
R-HSA-9669921 KIT mutants bind TKIs 0.004956 2.305
R-HSA-9669929 Regorafenib-resistant KIT mutants 0.004956 2.305
R-HSA-9669924 Masitinib-resistant KIT mutants 0.004956 2.305
R-HSA-9669926 Nilotinib-resistant KIT mutants 0.004956 2.305
R-HSA-9669936 Sorafenib-resistant KIT mutants 0.004956 2.305
R-HSA-9669934 Sunitinib-resistant KIT mutants 0.004956 2.305
R-HSA-9669914 Dasatinib-resistant KIT mutants 0.004956 2.305
R-HSA-9669917 Imatinib-resistant KIT mutants 0.004956 2.305
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 0.002613 2.583
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.005023 2.299
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 0.003334 2.477
R-HSA-381119 Unfolded Protein Response (UPR) 0.007770 2.110
R-HSA-373756 SDK interactions 0.009887 2.005
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.011937 1.923
R-HSA-9680187 Signaling by extracellular domain mutants of KIT 0.014795 1.830
R-HSA-9669935 Signaling by juxtamembrane domain KIT mutants 0.014795 1.830
R-HSA-9669933 Signaling by kinase domain mutants of KIT 0.014795 1.830
R-HSA-913531 Interferon Signaling 0.015455 1.811
R-HSA-5673000 RAF activation 0.017963 1.746
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.017963 1.746
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.020491 1.688
R-HSA-9656223 Signaling by RAF1 mutants 0.025013 1.602
R-HSA-9649948 Signaling downstream of RAS mutants 0.029900 1.524
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.029900 1.524
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.029900 1.524
R-HSA-72163 mRNA Splicing - Major Pathway 0.021882 1.660
R-HSA-72172 mRNA Splicing 0.025705 1.590
R-HSA-5674135 MAP2K and MAPK activation 0.025013 1.602
R-HSA-6802949 Signaling by RAS mutants 0.029900 1.524
R-HSA-212165 Epigenetic regulation of gene expression 0.028300 1.548
R-HSA-5675221 Negative regulation of MAPK pathway 0.025013 1.602
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.025961 1.586
R-HSA-72737 Cap-dependent Translation Initiation 0.027285 1.564
R-HSA-72613 Eukaryotic Translation Initiation 0.027285 1.564
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.022224 1.653
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.027902 1.554
R-HSA-111957 Cam-PDE 1 activation 0.038974 1.409
R-HSA-9732724 IFNG signaling activates MAPKs 0.048481 1.314
R-HSA-72731 Recycling of eIF2:GDP 0.048481 1.314
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 0.053200 1.274
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.071844 1.144
R-HSA-1433559 Regulation of KIT signaling 0.085588 1.068
R-HSA-163210 Formation of ATP by chemiosmotic coupling 0.116882 0.932
R-HSA-9669938 Signaling by KIT in disease 0.129968 0.886
R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... 0.129968 0.886
R-HSA-350054 Notch-HLH transcription pathway 0.129968 0.886
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 0.138586 0.858
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.051464 1.288
R-HSA-167161 HIV Transcription Initiation 0.216359 0.665
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.216359 0.665
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.231826 0.635
R-HSA-774815 Nucleosome assembly 0.231826 0.635
R-HSA-72165 mRNA Splicing - Minor Pathway 0.235646 0.628
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.120140 0.920
R-HSA-1433557 Signaling by SCF-KIT 0.224131 0.649
R-HSA-6802957 Oncogenic MAPK signaling 0.078459 1.105
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.147119 0.832
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.184496 0.734
R-HSA-446107 Type I hemidesmosome assembly 0.053200 1.274
R-HSA-156711 Polo-like kinase mediated events 0.108051 0.966
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.208510 0.681
R-HSA-1236977 Endosomal/Vacuolar pathway 0.071844 1.144
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.099132 1.004
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.231826 0.635
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.076448 1.117
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 0.151354 0.820
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.184496 0.734
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.246992 0.607
R-HSA-2424491 DAP12 signaling 0.163935 0.785
R-HSA-9842860 Regulation of endogenous retroelements 0.108860 0.963
R-HSA-73776 RNA Polymerase II Promoter Escape 0.224131 0.649
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.216359 0.665
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.210629 0.676
R-HSA-8949613 Cristae formation 0.151354 0.820
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.208510 0.681
R-HSA-170968 Frs2-mediated activation 0.081029 1.091
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.062067 1.207
R-HSA-9843745 Adipogenesis 0.165963 0.780
R-HSA-2172127 DAP12 interactions 0.227988 0.642
R-HSA-169893 Prolonged ERK activation events 0.094640 1.024
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.208510 0.681
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.208510 0.681
R-HSA-165159 MTOR signalling 0.220254 0.657
R-HSA-187706 Signalling to p38 via RIT and RIN 0.038974 1.409
R-HSA-170984 ARMS-mediated activation 0.057895 1.237
R-HSA-5673001 RAF/MAP kinase cascade 0.198860 0.701
R-HSA-9909396 Circadian clock 0.167717 0.775
R-HSA-5684996 MAPK1/MAPK3 signaling 0.207783 0.682
R-HSA-1679131 Trafficking and processing of endosomal TLR 0.076448 1.117
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.163935 0.785
R-HSA-187687 Signalling to ERKs 0.188547 0.725
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.138586 0.858
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 0.103602 0.985
R-HSA-8943724 Regulation of PTEN gene transcription 0.045364 1.343
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.135044 0.870
R-HSA-418457 cGMP effects 0.085588 1.068
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.094640 1.024
R-HSA-166208 mTORC1-mediated signalling 0.129968 0.886
R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma ... 0.151354 0.820
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.060465 1.218
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.204557 0.689
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.188547 0.725
R-HSA-194138 Signaling by VEGF 0.153785 0.813
R-HSA-430116 GP1b-IX-V activation signalling 0.057895 1.237
R-HSA-173599 Formation of the active cofactor, UDP-glucuronate 0.085588 1.068
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.134288 0.872
R-HSA-3000480 Scavenging by Class A Receptors 0.216359 0.665
R-HSA-1295596 Spry regulation of FGF signaling 0.090125 1.045
R-HSA-1369062 ABC transporters in lipid homeostasis 0.134288 0.872
R-HSA-202433 Generation of second messenger molecules 0.208510 0.681
R-HSA-9637628 Modulation by Mtb of host immune system 0.053200 1.274
R-HSA-9755088 Ribavirin ADME 0.125628 0.901
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.220254 0.657
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.050722 1.295
R-HSA-392517 Rap1 signalling 0.112477 0.949
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.155568 0.808
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.159762 0.797
R-HSA-392154 Nitric oxide stimulates guanylate cyclase 0.159762 0.797
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.184496 0.734
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.163935 0.785
R-HSA-3214841 PKMTs methylate histone lysines 0.212444 0.673
R-HSA-9734767 Developmental Cell Lineages 0.166652 0.778
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.176332 0.754
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.071354 1.147
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.048481 1.314
R-HSA-9018519 Estrogen-dependent gene expression 0.176533 0.753
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.121266 0.916
R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.151354 0.820
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.163935 0.785
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.204557 0.689
R-HSA-110329 Cleavage of the damaged pyrimidine 0.220254 0.657
R-HSA-73928 Depyrimidination 0.220254 0.657
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.184496 0.734
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.140102 0.854
R-HSA-111933 Calmodulin induced events 0.192579 0.715
R-HSA-111997 CaM pathway 0.192579 0.715
R-HSA-1257604 PIP3 activates AKT signaling 0.206502 0.685
R-HSA-9860931 Response of endothelial cells to shear stress 0.112053 0.951
R-HSA-9006925 Intracellular signaling by second messengers 0.106246 0.974
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.172220 0.764
R-HSA-111996 Ca-dependent events 0.220254 0.657
R-HSA-9833110 RSV-host interactions 0.113658 0.944
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.176332 0.754
R-HSA-1489509 DAG and IP3 signaling 0.231826 0.635
R-HSA-6807070 PTEN Regulation 0.181859 0.740
R-HSA-3247509 Chromatin modifying enzymes 0.132866 0.877
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.212444 0.673
R-HSA-9855142 Cellular responses to mechanical stimuli 0.130029 0.886
R-HSA-72766 Translation 0.185506 0.732
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.243228 0.614
R-HSA-2672351 Stimuli-sensing channels 0.120140 0.920
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.176332 0.754
R-HSA-4839726 Chromatin organization 0.150025 0.824
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.134288 0.872
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.184496 0.734
R-HSA-1592230 Mitochondrial biogenesis 0.138411 0.859
R-HSA-388841 Regulation of T cell activation by CD28 family 0.158269 0.801
R-HSA-389356 Co-stimulation by CD28 0.243228 0.614
R-HSA-446728 Cell junction organization 0.185042 0.733
R-HSA-5654743 Signaling by FGFR4 0.224131 0.649
R-HSA-9682706 Replication of the SARS-CoV-1 genome 0.081029 1.091
R-HSA-5654741 Signaling by FGFR3 0.231826 0.635
R-HSA-9694686 Replication of the SARS-CoV-2 genome 0.103602 0.985
R-HSA-1500931 Cell-Cell communication 0.233752 0.631
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription 0.085588 1.068
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription 0.112477 0.949
R-HSA-8948216 Collagen chain trimerization 0.196592 0.706
R-HSA-6804757 Regulation of TP53 Degradation 0.192579 0.715
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.204557 0.689
R-HSA-8953897 Cellular responses to stimuli 0.124058 0.906
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.212444 0.673
R-HSA-381038 XBP1(S) activates chaperone genes 0.081361 1.090
R-HSA-2262752 Cellular responses to stress 0.143892 0.842
R-HSA-5633007 Regulation of TP53 Activity 0.221541 0.655
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.178306 0.749
R-HSA-381070 IRE1alpha activates chaperones 0.090262 1.044
R-HSA-9748787 Azathioprine ADME 0.250737 0.601
R-HSA-8953854 Metabolism of RNA 0.252036 0.599
R-HSA-3371571 HSF1-dependent transactivation 0.254464 0.594
R-HSA-9639288 Amino acids regulate mTORC1 0.261862 0.582
R-HSA-156588 Glucuronidation 0.265534 0.576
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.265534 0.576
R-HSA-3214815 HDACs deacetylate histones 0.269188 0.570
R-HSA-9012852 Signaling by NOTCH3 0.269188 0.570
R-HSA-72702 Ribosomal scanning and start codon recognition 0.272824 0.564
R-HSA-5578775 Ion homeostasis 0.272824 0.564
R-HSA-5654736 Signaling by FGFR1 0.272824 0.564
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.272824 0.564
R-HSA-5683057 MAPK family signaling cascades 0.275053 0.561
R-HSA-983712 Ion channel transport 0.276582 0.558
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.280042 0.553
R-HSA-186712 Regulation of beta-cell development 0.283625 0.547
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.283625 0.547
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.287190 0.542
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.287190 0.542
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.287190 0.542
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.287190 0.542
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.287190 0.542
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.287190 0.542
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.287190 0.542
R-HSA-9793380 Formation of paraxial mesoderm 0.290738 0.536
R-HSA-112043 PLC beta mediated events 0.290738 0.536
R-HSA-1442490 Collagen degradation 0.290738 0.536
R-HSA-1268020 Mitochondrial protein import 0.294268 0.531
R-HSA-9707616 Heme signaling 0.294268 0.531
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.294268 0.531
R-HSA-389948 Co-inhibition by PD-1 0.296789 0.528
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.297780 0.526
R-HSA-1280215 Cytokine Signaling in Immune system 0.301356 0.521
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.308215 0.511
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.308215 0.511
R-HSA-112040 G-protein mediated events 0.311660 0.506
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.315087 0.502
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.315087 0.502
R-HSA-167172 Transcription of the HIV genome 0.315087 0.502
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.321891 0.492
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.321891 0.492
R-HSA-427413 NoRC negatively regulates rRNA expression 0.325268 0.488
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.325268 0.488
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.325268 0.488
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.335299 0.475
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 0.335299 0.475
R-HSA-9013694 Signaling by NOTCH4 0.335299 0.475
R-HSA-162582 Signal Transduction 0.340603 0.468
R-HSA-1980143 Signaling by NOTCH1 0.341905 0.466
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.341905 0.466
R-HSA-162906 HIV Infection 0.347773 0.459
R-HSA-383280 Nuclear Receptor transcription pathway 0.348446 0.458
R-HSA-73864 RNA Polymerase I Transcription 0.348446 0.458
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.351375 0.454
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.351692 0.454
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.354922 0.450
R-HSA-5654738 Signaling by FGFR2 0.354922 0.450
R-HSA-977225 Amyloid fiber formation 0.358137 0.446
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.358137 0.446
R-HSA-9707564 Cytoprotection by HMOX1 0.364518 0.438
R-HSA-8939211 ESR-mediated signaling 0.365719 0.437
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.367685 0.435
R-HSA-141424 Amplification of signal from the kinetochores 0.373973 0.427
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.373973 0.427
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.377094 0.424
R-HSA-1236974 ER-Phagosome pathway 0.386364 0.413
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.386921 0.412
R-HSA-73884 Base Excision Repair 0.389424 0.410
R-HSA-202424 Downstream TCR signaling 0.389424 0.410
R-HSA-421270 Cell-cell junction organization 0.390528 0.408
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.392468 0.406
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.404497 0.393
R-HSA-9837999 Mitochondrial protein degradation 0.404497 0.393
R-HSA-1474290 Collagen formation 0.404497 0.393
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.413365 0.384
R-HSA-8878159 Transcriptional regulation by RUNX3 0.416291 0.381
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.416291 0.381
R-HSA-8957275 Post-translational protein phosphorylation 0.419204 0.378
R-HSA-190236 Signaling by FGFR 0.419204 0.378
R-HSA-3214847 HATs acetylate histones 0.422102 0.375
R-HSA-69618 Mitotic Spindle Checkpoint 0.424985 0.372
R-HSA-382556 ABC-family proteins mediated transport 0.424985 0.372
R-HSA-111885 Opioid Signalling 0.436378 0.360
R-HSA-1280218 Adaptive Immune System 0.438439 0.358
R-HSA-418346 Platelet homeostasis 0.444777 0.352
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.447548 0.349
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.447548 0.349
R-HSA-9700206 Signaling by ALK in cancer 0.447548 0.349
R-HSA-1236975 Antigen processing-Cross presentation 0.450307 0.346
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.453051 0.344
R-HSA-202403 TCR signaling 0.455782 0.341
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.463895 0.334
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.469237 0.329
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.471888 0.326
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.490084 0.310
R-HSA-73886 Chromosome Maintenance 0.490084 0.310
R-HSA-3371556 Cellular response to heat stress 0.490084 0.310
R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.490084 0.310
R-HSA-2132295 MHC class II antigen presentation 0.495168 0.305
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.495168 0.305
R-HSA-162909 Host Interactions of HIV factors 0.497692 0.303
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.502701 0.299
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.502701 0.299
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.502701 0.299
R-HSA-1852241 Organelle biogenesis and maintenance 0.505664 0.296
R-HSA-9824446 Viral Infection Pathways 0.509932 0.292
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.510122 0.292
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.515009 0.288
R-HSA-5576891 Cardiac conduction 0.519848 0.284
R-HSA-1474228 Degradation of the extracellular matrix 0.522249 0.282
R-HSA-74160 Gene expression (Transcription) 0.535222 0.271
R-HSA-1632852 Macroautophagy 0.545621 0.263
R-HSA-9679506 SARS-CoV Infections 0.548771 0.261
R-HSA-9694516 SARS-CoV-2 Infection 0.549799 0.260
R-HSA-162599 Late Phase of HIV Life Cycle 0.550158 0.260
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.550158 0.260
R-HSA-166520 Signaling by NTRKs 0.563502 0.249
R-HSA-9758941 Gastrulation 0.565688 0.247
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.567862 0.246
R-HSA-9679191 Potential therapeutics for SARS 0.567862 0.246
R-HSA-9006931 Signaling by Nuclear Receptors 0.570116 0.244
R-HSA-9609507 Protein localization 0.574323 0.241
R-HSA-1989781 PPARA activates gene expression 0.578577 0.238
R-HSA-9612973 Autophagy 0.580688 0.236
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.582788 0.234
R-HSA-162587 HIV Life Cycle 0.582788 0.234
R-HSA-9711097 Cellular response to starvation 0.584879 0.233
R-HSA-9006936 Signaling by TGFB family members 0.589028 0.230
R-HSA-2467813 Separation of Sister Chromatids 0.597205 0.224
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.611130 0.214
R-HSA-72306 tRNA processing 0.611130 0.214
R-HSA-5621481 C-type lectin receptors (CLRs) 0.613080 0.212
R-HSA-418555 G alpha (s) signalling events 0.613080 0.212
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.615020 0.211
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.616951 0.210
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.616951 0.210
R-HSA-9678108 SARS-CoV-1 Infection 0.620784 0.207
R-HSA-73857 RNA Polymerase II Transcription 0.628141 0.202
R-HSA-69275 G2/M Transition 0.641197 0.193
R-HSA-453274 Mitotic G2-G2/M phases 0.644790 0.191
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.644790 0.191
R-HSA-168898 Toll-like Receptor Cascades 0.650113 0.187
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.651870 0.186
R-HSA-68877 Mitotic Prometaphase 0.653618 0.185
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.658811 0.181
R-HSA-212436 Generic Transcription Pathway 0.675451 0.170
R-HSA-392499 Metabolism of proteins 0.678084 0.169
R-HSA-397014 Muscle contraction 0.686816 0.163
R-HSA-9730414 MITF-M-regulated melanocyte development 0.688390 0.162
R-HSA-68882 Mitotic Anaphase 0.693068 0.159
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.694612 0.158
R-HSA-9748784 Drug ADME 0.696148 0.157
R-HSA-418990 Adherens junctions interactions 0.696148 0.157
R-HSA-3700989 Transcriptional Regulation by TP53 0.699364 0.155
R-HSA-8878171 Transcriptional regulation by RUNX1 0.708164 0.150
R-HSA-9705683 SARS-CoV-2-host interactions 0.711094 0.148
R-HSA-72312 rRNA processing 0.716867 0.145
R-HSA-156580 Phase II - Conjugation of compounds 0.726698 0.139
R-HSA-157118 Signaling by NOTCH 0.728074 0.138
R-HSA-382551 Transport of small molecules 0.740845 0.130
R-HSA-69620 Cell Cycle Checkpoints 0.751713 0.124
R-HSA-9711123 Cellular response to chemical stress 0.763956 0.117
R-HSA-76002 Platelet activation, signaling and aggregation 0.771014 0.113
R-HSA-1643685 Disease 0.779919 0.108
R-HSA-69278 Cell Cycle, Mitotic 0.793571 0.100
R-HSA-8957322 Metabolism of steroids 0.822275 0.085
R-HSA-1474244 Extracellular matrix organization 0.828481 0.082
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.836977 0.077
R-HSA-73894 DNA Repair 0.851990 0.070
R-HSA-5663205 Infectious disease 0.865286 0.063
R-HSA-68886 M Phase 0.868348 0.061
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.869017 0.061
R-HSA-1266738 Developmental Biology 0.871704 0.060
R-HSA-9824439 Bacterial Infection Pathways 0.873608 0.059
R-HSA-425407 SLC-mediated transmembrane transport 0.878040 0.056
R-HSA-1640170 Cell Cycle 0.882225 0.054
R-HSA-418594 G alpha (i) signalling events 0.884106 0.053
R-HSA-168256 Immune System 0.906495 0.043
R-HSA-6798695 Neutrophil degranulation 0.910245 0.041
R-HSA-109582 Hemostasis 0.913892 0.039
R-HSA-597592 Post-translational protein modification 0.929555 0.032
R-HSA-211859 Biological oxidations 0.936028 0.029
R-HSA-449147 Signaling by Interleukins 0.962202 0.017
R-HSA-168249 Innate Immune System 0.968434 0.014
R-HSA-388396 GPCR downstream signalling 0.982585 0.008
R-HSA-5653656 Vesicle-mediated transport 0.985423 0.006
R-HSA-372790 Signaling by GPCR 0.988727 0.005
R-HSA-556833 Metabolism of lipids 0.999619 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CDC7CDC7 0.783 0.116 1 0.728
COTCOT 0.775 0.056 2 0.699
CLK3CLK3 0.773 0.121 1 0.632
MOSMOS 0.773 0.081 1 0.739
DSTYKDSTYK 0.772 0.092 2 0.705
IKKEIKKE 0.769 0.067 1 0.649
IKKBIKKB 0.768 -0.025 -2 0.579
RAF1RAF1 0.768 0.024 1 0.707
PRPKPRPK 0.768 -0.097 -1 0.804
BMPR1BBMPR1B 0.768 0.135 1 0.672
BMPR2BMPR2 0.768 0.105 -2 0.771
TBK1TBK1 0.767 0.020 1 0.634
NEK6NEK6 0.766 0.085 -2 0.790
FAM20CFAM20C 0.765 0.050 2 0.496
CAMK2GCAMK2G 0.765 -0.046 2 0.674
MARK4MARK4 0.765 0.020 4 0.791
ULK2ULK2 0.765 -0.040 2 0.648
TSSK2TSSK2 0.764 0.034 -5 0.749
TGFBR2TGFBR2 0.764 0.107 -2 0.758
CHAK2CHAK2 0.764 0.067 -1 0.767
NEK7NEK7 0.763 0.024 -3 0.810
PDHK1PDHK1 0.763 -0.052 1 0.707
GCN2GCN2 0.763 -0.068 2 0.661
ACVR2BACVR2B 0.762 0.168 -2 0.765
MTORMTOR 0.762 -0.056 1 0.601
GRK6GRK6 0.761 -0.011 1 0.681
PDHK4PDHK4 0.761 -0.165 1 0.689
IKKAIKKA 0.761 -0.008 -2 0.573
ACVR2AACVR2A 0.761 0.161 -2 0.773
PIM3PIM3 0.761 -0.023 -3 0.741
GRK5GRK5 0.761 -0.058 -3 0.832
GRK1GRK1 0.760 0.013 -2 0.561
CAMK1BCAMK1B 0.760 -0.068 -3 0.810
PRKD1PRKD1 0.759 -0.006 -3 0.724
TSSK1TSSK1 0.759 0.029 -3 0.786
TGFBR1TGFBR1 0.758 0.047 -2 0.682
BMPR1ABMPR1A 0.758 0.122 1 0.676
PLK1PLK1 0.757 0.111 -2 0.787
ATRATR 0.757 -0.077 1 0.618
HIPK4HIPK4 0.757 0.000 1 0.604
NLKNLK 0.757 -0.057 1 0.627
KISKIS 0.756 0.023 1 0.506
GRK7GRK7 0.756 0.096 1 0.594
MST4MST4 0.755 0.024 2 0.695
ULK1ULK1 0.755 -0.069 -3 0.810
NUAK2NUAK2 0.754 -0.023 -3 0.769
GRK4GRK4 0.754 -0.039 -2 0.671
AMPKA1AMPKA1 0.754 -0.022 -3 0.774
PRKD2PRKD2 0.753 0.002 -3 0.681
SRPK1SRPK1 0.753 0.016 -3 0.673
ALK2ALK2 0.753 0.079 -2 0.684
ATMATM 0.753 -0.025 1 0.573
MARK2MARK2 0.752 0.029 4 0.763
CDK1CDK1 0.752 0.069 1 0.453
MARK3MARK3 0.752 0.033 4 0.764
SKMLCKSKMLCK 0.752 -0.059 -2 0.672
ALK4ALK4 0.752 0.019 -2 0.707
MLK1MLK1 0.751 -0.087 2 0.631
CK2A2CK2A2 0.751 0.098 1 0.635
QSKQSK 0.751 0.015 4 0.761
PLK3PLK3 0.751 0.034 2 0.652
TLK2TLK2 0.750 0.032 1 0.622
DAPK2DAPK2 0.750 -0.076 -3 0.809
CDKL1CDKL1 0.750 -0.055 -3 0.738
CAMLCKCAMLCK 0.750 -0.086 -2 0.685
CAMK2DCAMK2D 0.749 -0.083 -3 0.777
ERK5ERK5 0.749 -0.111 1 0.579
NIKNIK 0.749 -0.129 -3 0.825
CDK2CDK2 0.749 0.124 1 0.519
RSK2RSK2 0.748 -0.040 -3 0.692
WNK3WNK3 0.748 -0.138 1 0.645
WNK1WNK1 0.748 -0.084 -2 0.694
CAMK2BCAMK2B 0.748 -0.033 2 0.658
ANKRD3ANKRD3 0.747 -0.078 1 0.667
HUNKHUNK 0.747 -0.150 2 0.671
BCKDKBCKDK 0.747 -0.116 -1 0.732
NEK9NEK9 0.746 -0.109 2 0.670
NDR2NDR2 0.746 -0.111 -3 0.743
AMPKA2AMPKA2 0.746 -0.036 -3 0.739
PIM1PIM1 0.746 -0.029 -3 0.696
CDK3CDK3 0.746 0.130 1 0.409
PKRPKR 0.746 0.009 1 0.672
CDK8CDK8 0.746 -0.055 1 0.488
MEK1MEK1 0.745 -0.075 2 0.713
RIPK3RIPK3 0.744 -0.158 3 0.583
SRPK3SRPK3 0.744 0.017 -3 0.667
YSK4YSK4 0.744 -0.002 1 0.640
NIM1NIM1 0.744 -0.091 3 0.613
DLKDLK 0.743 -0.139 1 0.644
TTBK2TTBK2 0.742 -0.115 2 0.557
PKN3PKN3 0.742 -0.116 -3 0.761
MARK1MARK1 0.742 -0.016 4 0.762
SIKSIK 0.742 -0.027 -3 0.710
CDKL5CDKL5 0.742 -0.063 -3 0.722
LATS1LATS1 0.742 0.022 -3 0.747
CLK4CLK4 0.742 0.002 -3 0.701
CLK2CLK2 0.741 0.045 -3 0.666
HRIHRI 0.741 0.047 -2 0.801
SMG1SMG1 0.741 -0.060 1 0.580
SRPK2SRPK2 0.741 0.006 -3 0.607
CK2A1CK2A1 0.741 0.074 1 0.614
PERKPERK 0.741 0.045 -2 0.770
CAMK2ACAMK2A 0.741 -0.038 2 0.661
VRK2VRK2 0.741 -0.146 1 0.685
MAPKAPK2MAPKAPK2 0.741 -0.051 -3 0.631
MASTLMASTL 0.741 -0.259 -2 0.667
DYRK2DYRK2 0.741 -0.051 1 0.539
BRSK1BRSK1 0.740 -0.056 -3 0.720
PKN2PKN2 0.740 -0.086 -3 0.775
JNK3JNK3 0.740 -0.022 1 0.472
TLK1TLK1 0.740 0.025 -2 0.737
CLK1CLK1 0.739 0.022 -3 0.683
GSK3BGSK3B 0.739 0.028 4 0.452
P90RSKP90RSK 0.739 -0.087 -3 0.690
RIPK1RIPK1 0.739 -0.191 1 0.619
ICKICK 0.739 -0.085 -3 0.761
DNAPKDNAPK 0.739 -0.010 1 0.545
P70S6KBP70S6KB 0.739 -0.087 -3 0.734
RSK3RSK3 0.739 -0.072 -3 0.688
CDK5CDK5 0.739 0.006 1 0.500
SSTKSSTK 0.738 0.005 4 0.756
NUAK1NUAK1 0.738 -0.056 -3 0.725
CHAK1CHAK1 0.738 -0.045 2 0.645
PKCDPKCD 0.738 -0.064 2 0.618
QIKQIK 0.738 -0.091 -3 0.787
MLK3MLK3 0.738 -0.064 2 0.564
MAPKAPK3MAPKAPK3 0.738 -0.101 -3 0.686
PLK4PLK4 0.738 -0.008 2 0.551
AURCAURC 0.738 -0.025 -2 0.499
IRE1IRE1 0.738 -0.111 1 0.611
JNK2JNK2 0.738 -0.014 1 0.444
BRSK2BRSK2 0.737 -0.065 -3 0.749
NDR1NDR1 0.737 -0.136 -3 0.745
P38DP38D 0.737 0.003 1 0.408
PRKD3PRKD3 0.736 -0.046 -3 0.684
MLK2MLK2 0.736 -0.180 2 0.672
CDK19CDK19 0.736 -0.064 1 0.459
GSK3AGSK3A 0.735 0.024 4 0.462
NEK2NEK2 0.735 -0.100 2 0.652
PKACGPKACG 0.735 -0.084 -2 0.560
MLK4MLK4 0.735 -0.074 2 0.562
LATS2LATS2 0.735 -0.108 -5 0.565
BRAFBRAF 0.735 -0.055 -4 0.820
PAK1PAK1 0.735 -0.094 -2 0.612
P38BP38B 0.734 -0.031 1 0.448
PINK1PINK1 0.733 -0.105 1 0.626
CDK13CDK13 0.732 -0.074 1 0.470
AURBAURB 0.732 -0.048 -2 0.495
AURAAURA 0.732 -0.040 -2 0.466
MELKMELK 0.732 -0.107 -3 0.732
CHK1CHK1 0.732 -0.096 -3 0.722
IRE2IRE2 0.731 -0.112 2 0.589
PAK6PAK6 0.731 -0.049 -2 0.550
PAK3PAK3 0.731 -0.125 -2 0.617
MEKK3MEKK3 0.731 -0.085 1 0.628
MNK2MNK2 0.731 -0.072 -2 0.636
MSK2MSK2 0.730 -0.104 -3 0.659
PLK2PLK2 0.730 0.022 -3 0.707
GRK2GRK2 0.729 -0.097 -2 0.533
MSK1MSK1 0.729 -0.065 -3 0.666
CDK7CDK7 0.729 -0.074 1 0.491
P38GP38G 0.729 -0.040 1 0.387
PRP4PRP4 0.728 -0.056 -3 0.641
CAMK4CAMK4 0.728 -0.172 -3 0.759
P38AP38A 0.728 -0.067 1 0.497
GAKGAK 0.728 0.018 1 0.671
MEKK2MEKK2 0.728 -0.071 2 0.651
TAO3TAO3 0.727 0.002 1 0.624
MYLK4MYLK4 0.727 -0.092 -2 0.589
PAK2PAK2 0.727 -0.135 -2 0.595
CK1G1CK1G1 0.726 -0.022 -3 0.531
PKACBPKACB 0.726 -0.042 -2 0.518
DYRK4DYRK4 0.726 -0.044 1 0.471
ERK1ERK1 0.726 -0.060 1 0.438
PKCBPKCB 0.725 -0.087 2 0.557
PKG2PKG2 0.725 -0.057 -2 0.517
JNK1JNK1 0.725 -0.024 1 0.440
HIPK2HIPK2 0.725 -0.042 1 0.464
PKCAPKCA 0.725 -0.088 2 0.557
MEKK1MEKK1 0.725 -0.134 1 0.645
ZAKZAK 0.725 -0.115 1 0.621
RSK4RSK4 0.725 -0.068 -3 0.650
DCAMKL1DCAMKL1 0.724 -0.083 -3 0.699
DRAK1DRAK1 0.724 -0.141 1 0.533
NEK5NEK5 0.723 -0.123 1 0.630
PRKXPRKX 0.723 -0.013 -3 0.585
CDK12CDK12 0.723 -0.082 1 0.445
MEK5MEK5 0.723 -0.228 2 0.687
SNRKSNRK 0.722 -0.190 2 0.589
TTBK1TTBK1 0.722 -0.111 2 0.486
MNK1MNK1 0.722 -0.086 -2 0.647
DYRK1ADYRK1A 0.722 -0.071 1 0.537
ERK2ERK2 0.722 -0.089 1 0.469
CAMKK1CAMKK1 0.722 -0.102 -2 0.603
WNK4WNK4 0.722 -0.146 -2 0.705
PKCZPKCZ 0.722 -0.116 2 0.609
HIPK1HIPK1 0.722 -0.064 1 0.552
EEF2KEEF2K 0.721 0.027 3 0.779
CDK9CDK9 0.721 -0.098 1 0.477
PKCHPKCH 0.721 -0.124 2 0.543
MAPKAPK5MAPKAPK5 0.721 -0.148 -3 0.653
PIM2PIM2 0.720 -0.074 -3 0.684
GRK3GRK3 0.720 -0.082 -2 0.480
CK1ECK1E 0.720 -0.065 -3 0.522
MINKMINK 0.720 0.074 1 0.659
MST3MST3 0.720 -0.063 2 0.664
MST2MST2 0.720 0.008 1 0.665
AKT2AKT2 0.719 -0.053 -3 0.626
PASKPASK 0.719 -0.078 -3 0.760
PKCGPKCG 0.719 -0.125 2 0.548
CDK18CDK18 0.719 -0.075 1 0.432
CK1DCK1D 0.719 -0.037 -3 0.485
SGK3SGK3 0.719 -0.088 -3 0.677
CAMK1GCAMK1G 0.719 -0.115 -3 0.718
TNIKTNIK 0.719 0.078 3 0.775
IRAK4IRAK4 0.719 -0.140 1 0.624
PHKG1PHKG1 0.718 -0.151 -3 0.743
HGKHGK 0.718 0.029 3 0.755
MPSK1MPSK1 0.717 -0.057 1 0.609
DYRK1BDYRK1B 0.717 -0.073 1 0.491
CDK17CDK17 0.717 -0.077 1 0.389
DCAMKL2DCAMKL2 0.716 -0.099 -3 0.737
NEK8NEK8 0.716 -0.132 2 0.649
TAK1TAK1 0.716 -0.011 1 0.647
GCKGCK 0.716 0.036 1 0.652
CAMKK2CAMKK2 0.716 -0.115 -2 0.601
TAO2TAO2 0.715 -0.084 2 0.681
SMMLCKSMMLCK 0.715 -0.120 -3 0.765
PHKG2PHKG2 0.715 -0.108 -3 0.751
CK1A2CK1A2 0.714 -0.048 -3 0.484
IRAK1IRAK1 0.714 -0.212 -1 0.704
HIPK3HIPK3 0.714 -0.095 1 0.536
DYRK3DYRK3 0.714 -0.080 1 0.565
P70S6KP70S6K 0.713 -0.103 -3 0.654
PKACAPKACA 0.713 -0.052 -2 0.479
NEK11NEK11 0.712 -0.144 1 0.612
DAPK3DAPK3 0.712 -0.076 -3 0.726
CAMK1DCAMK1D 0.712 -0.091 -3 0.613
MST1MST1 0.712 0.010 1 0.655
TTKTTK 0.711 0.129 -2 0.792
LKB1LKB1 0.711 -0.118 -3 0.771
PDK1PDK1 0.711 -0.142 1 0.602
MEK2MEK2 0.711 -0.117 2 0.692
NEK4NEK4 0.710 -0.121 1 0.643
HPK1HPK1 0.710 0.010 1 0.657
KHS1KHS1 0.709 0.044 1 0.669
VRK1VRK1 0.709 -0.140 2 0.668
STK33STK33 0.707 -0.114 2 0.502
ALPHAK3ALPHAK3 0.707 0.039 -1 0.741
AKT1AKT1 0.707 -0.071 -3 0.632
PKCTPKCT 0.707 -0.130 2 0.563
KHS2KHS2 0.707 0.057 1 0.669
CDK6CDK6 0.707 -0.039 1 0.455
LOKLOK 0.706 -0.060 -2 0.638
PKCIPKCI 0.706 -0.111 2 0.566
PAK5PAK5 0.706 -0.103 -2 0.491
DAPK1DAPK1 0.706 -0.088 -3 0.713
PBKPBK 0.706 -0.026 1 0.615
LRRK2LRRK2 0.706 -0.156 2 0.683
MAP3K15MAP3K15 0.705 -0.142 1 0.599
BUB1BUB1 0.705 -0.009 -5 0.679
ERK7ERK7 0.705 -0.080 2 0.364
CDK14CDK14 0.704 -0.105 1 0.474
NEK1NEK1 0.704 -0.146 1 0.625
MEKK6MEKK6 0.704 -0.152 1 0.615
PAK4PAK4 0.703 -0.098 -2 0.492
SLKSLK 0.703 -0.050 -2 0.577
CDK16CDK16 0.702 -0.088 1 0.406
PKCEPKCE 0.702 -0.074 2 0.533
MAKMAK 0.701 -0.033 -2 0.589
RIPK2RIPK2 0.701 -0.207 1 0.580
MRCKAMRCKA 0.700 -0.063 -3 0.685
CDK4CDK4 0.700 -0.073 1 0.443
OSR1OSR1 0.700 -0.015 2 0.665
CHK2CHK2 0.700 -0.069 -3 0.571
CDK10CDK10 0.700 -0.084 1 0.457
BIKEBIKE 0.699 0.007 1 0.590
SBKSBK 0.698 -0.056 -3 0.509
YSK1YSK1 0.698 -0.118 2 0.643
SGK1SGK1 0.697 -0.060 -3 0.530
PDHK3_TYRPDHK3_TYR 0.697 0.084 4 0.745
MRCKBMRCKB 0.696 -0.076 -3 0.680
MYO3AMYO3A 0.696 0.004 1 0.653
CAMK1ACAMK1A 0.695 -0.095 -3 0.593
PKN1PKN1 0.694 -0.120 -3 0.666
ROCK2ROCK2 0.694 -0.081 -3 0.698
YANK3YANK3 0.693 -0.069 2 0.330
AKT3AKT3 0.692 -0.066 -3 0.543
MOKMOK 0.692 -0.075 1 0.556
NEK3NEK3 0.692 -0.164 1 0.591
MYO3BMYO3B 0.692 -0.047 2 0.667
HASPINHASPIN 0.691 -0.062 -1 0.594
PKG1PKG1 0.690 -0.082 -2 0.479
CK1ACK1A 0.689 -0.052 -3 0.403
MAP2K4_TYRMAP2K4_TYR 0.688 -0.003 -1 0.810
DMPK1DMPK1 0.688 -0.067 -3 0.697
MAP2K6_TYRMAP2K6_TYR 0.687 -0.011 -1 0.795
ASK1ASK1 0.686 -0.158 1 0.597
TAO1TAO1 0.686 -0.084 1 0.581
AAK1AAK1 0.684 0.028 1 0.507
PDHK1_TYRPDHK1_TYR 0.683 -0.039 -1 0.819
STLK3STLK3 0.682 -0.120 1 0.599
ROCK1ROCK1 0.681 -0.089 -3 0.680
BMPR2_TYRBMPR2_TYR 0.681 -0.029 -1 0.778
EPHA6EPHA6 0.681 0.028 -1 0.811
PDHK4_TYRPDHK4_TYR 0.680 -0.086 2 0.762
TESK1_TYRTESK1_TYR 0.680 -0.140 3 0.730
PKMYT1_TYRPKMYT1_TYR 0.679 -0.125 3 0.683
MAP2K7_TYRMAP2K7_TYR 0.679 -0.233 2 0.727
CRIKCRIK 0.679 -0.086 -3 0.622
CK1G3CK1G3 0.678 -0.025 -3 0.365
FERFER 0.677 -0.028 1 0.698
TXKTXK 0.676 0.066 1 0.670
EPHB4EPHB4 0.676 -0.027 -1 0.802
EPHA4EPHA4 0.676 0.005 2 0.661
TYK2TYK2 0.675 -0.082 1 0.643
EPHB2EPHB2 0.674 0.022 -1 0.795
PINK1_TYRPINK1_TYR 0.673 -0.214 1 0.639
SRMSSRMS 0.673 -0.005 1 0.691
ROS1ROS1 0.673 -0.062 3 0.617
HCKHCK 0.672 -0.001 -1 0.789
JAK2JAK2 0.672 -0.088 1 0.632
ABL2ABL2 0.671 -0.035 -1 0.814
EPHB1EPHB1 0.671 -0.036 1 0.678
ABL1ABL1 0.671 -0.028 -1 0.822
TYRO3TYRO3 0.670 -0.102 3 0.644
YES1YES1 0.670 -0.031 -1 0.820
LCKLCK 0.670 0.031 -1 0.791
RETRET 0.670 -0.143 1 0.633
LIMK1_TYRLIMK1_TYR 0.670 -0.181 2 0.707
EPHB3EPHB3 0.669 -0.035 -1 0.790
CSF1RCSF1R 0.669 -0.075 3 0.609
MST1RMST1R 0.669 -0.119 3 0.628
FLT3FLT3 0.669 -0.033 3 0.630
BLKBLK 0.669 0.041 -1 0.788
LIMK2_TYRLIMK2_TYR 0.669 -0.142 -3 0.822
PTK6PTK6 0.668 -0.041 -1 0.750
ITKITK 0.668 -0.015 -1 0.763
DDR1DDR1 0.667 -0.150 4 0.710
FGRFGR 0.667 -0.078 1 0.646
INSRRINSRR 0.667 -0.076 3 0.582
KITKIT 0.666 -0.060 3 0.615
TECTEC 0.664 -0.004 -1 0.755
BMXBMX 0.664 -0.010 -1 0.709
JAK1JAK1 0.664 -0.018 1 0.600
BTKBTK 0.664 -0.050 -1 0.750
FYNFYN 0.664 0.012 -1 0.758
JAK3JAK3 0.663 -0.114 1 0.594
NEK10_TYRNEK10_TYR 0.663 -0.053 1 0.535
MERTKMERTK 0.662 -0.082 3 0.576
TEKTEK 0.661 -0.100 3 0.586
TNNI3K_TYRTNNI3K_TYR 0.661 -0.043 1 0.643
EPHA7EPHA7 0.661 -0.048 2 0.656
PTK2BPTK2B 0.661 -0.008 -1 0.811
EPHA3EPHA3 0.661 -0.076 2 0.643
ALKALK 0.661 -0.078 3 0.553
WEE1_TYRWEE1_TYR 0.660 -0.050 -1 0.728
FRKFRK 0.660 -0.026 -1 0.805
FGFR1FGFR1 0.660 -0.124 3 0.575
TNK2TNK2 0.660 -0.106 3 0.571
YANK2YANK2 0.659 -0.089 2 0.331
AXLAXL 0.659 -0.121 3 0.580
EPHA5EPHA5 0.659 -0.033 2 0.657
PDGFRBPDGFRB 0.659 -0.157 3 0.636
FGFR2FGFR2 0.659 -0.148 3 0.606
LTKLTK 0.659 -0.100 3 0.562
LYNLYN 0.658 -0.031 3 0.550
CK1G2CK1G2 0.657 -0.058 -3 0.455
ERBB2ERBB2 0.656 -0.105 1 0.610
INSRINSR 0.655 -0.107 3 0.562
PDGFRAPDGFRA 0.655 -0.156 3 0.648
METMET 0.655 -0.103 3 0.595
SRCSRC 0.655 -0.025 -1 0.788
FGFR4FGFR4 0.655 -0.039 -1 0.774
NTRK1NTRK1 0.654 -0.153 -1 0.790
CSKCSK 0.654 -0.080 2 0.657
EPHA8EPHA8 0.654 -0.057 -1 0.757
EGFREGFR 0.653 -0.047 1 0.523
EPHA1EPHA1 0.653 -0.101 3 0.569
FGFR3FGFR3 0.652 -0.126 3 0.582
NTRK2NTRK2 0.652 -0.149 3 0.582
KDRKDR 0.652 -0.157 3 0.571
MATKMATK 0.651 -0.079 -1 0.757
FLT1FLT1 0.651 -0.103 -1 0.780
SYKSYK 0.651 -0.013 -1 0.706
TNK1TNK1 0.650 -0.180 3 0.613
NTRK3NTRK3 0.650 -0.113 -1 0.754
PTK2PTK2 0.650 -0.033 -1 0.699
EPHA2EPHA2 0.648 -0.058 -1 0.737
FLT4FLT4 0.645 -0.169 3 0.574
DDR2DDR2 0.645 -0.121 3 0.560
IGF1RIGF1R 0.642 -0.104 3 0.513
FESFES 0.641 -0.056 -1 0.722
ERBB4ERBB4 0.640 -0.065 1 0.561
MUSKMUSK 0.635 -0.133 1 0.509
ZAP70ZAP70 0.620 -0.066 -1 0.642