Motif 69 (n=220)

Position-wise Probabilities
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uniprot genes site source protein function
A6NC98 CCDC88B S1370 ochoa Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}.
A6NC98 CCDC88B S1410 ochoa Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}.
E7EW31 PROB1 S777 ochoa Proline-rich basic protein 1 None
O00443 PIK3C2A S259 ochoa|psp Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}.
O00571 DDX3X S492 ochoa ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}.
O15061 SYNM S1163 ochoa Synemin (Desmuslin) Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
O15151 MDM4 S96 psp Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}.
O15523 DDX3Y S490 ochoa ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}.
O43379 WDR62 S501 ochoa WD repeat-containing protein 62 Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.
O60313 OPA1 S478 ochoa Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)] Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28628083, PubMed:28746876, PubMed:31922487, PubMed:32228866, PubMed:32567732, PubMed:33130824, PubMed:33237841, PubMed:37612504, PubMed:37612506). Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form; L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form; S-OPA1), which results from proteolytic cleavage and localizes in the intermembrane space (PubMed:31922487, PubMed:32228866, PubMed:33237841, PubMed:37612504, PubMed:37612506). Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane (PubMed:31922487, PubMed:37612504, PubMed:37612506). The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S-OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion (PubMed:20038677, PubMed:31922487). The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology (By similarity). Involved in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing by PARL in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Acts as a regulator of T-helper Th17 cells, which are characterized by cells with fused mitochondria with tight cristae, by mediating mitochondrial membrane remodeling: OPA1 is required for interleukin-17 (IL-17) production (By similarity). Its role in mitochondrial morphology is required for mitochondrial genome maintenance (PubMed:18158317, PubMed:20974897). {ECO:0000250|UniProtKB:P58281, ECO:0000269|PubMed:16778770, ECO:0000269|PubMed:17709429, ECO:0000269|PubMed:18158317, ECO:0000269|PubMed:20038677, ECO:0000269|PubMed:20185555, ECO:0000269|PubMed:20974897, ECO:0000269|PubMed:24616225, ECO:0000269|PubMed:28628083, ECO:0000269|PubMed:28746876, ECO:0000269|PubMed:31922487, ECO:0000269|PubMed:32228866, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824, ECO:0000269|PubMed:33237841, ECO:0000269|PubMed:37612504, ECO:0000269|PubMed:37612506}.; FUNCTION: [Dynamin-like GTPase OPA1, long form]: Constitutes the transmembrane long form (L-OPA1) that plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:31922487, PubMed:32228866, PubMed:37612504, PubMed:37612506). L-OPA1 and the soluble short form (S-OPA1) form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (PubMed:31922487, PubMed:37612504, PubMed:37612506). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (PubMed:37612504, PubMed:37612506). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (PubMed:37612504, PubMed:37612506). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:28628083, PubMed:37612504, PubMed:37612506). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:32567732, PubMed:33130824). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (By similarity). {ECO:0000250|UniProtKB:G0SGC7, ECO:0000250|UniProtKB:P58281, ECO:0000269|PubMed:28628083, ECO:0000269|PubMed:31922487, ECO:0000269|PubMed:32228866, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824, ECO:0000269|PubMed:37612504, ECO:0000269|PubMed:37612506}.; FUNCTION: [Dynamin-like GTPase OPA1, short form]: Constitutes the soluble short form (S-OPA1) generated by cleavage by OMA1, which plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:31922487, PubMed:32228866, PubMed:32245890, PubMed:37612504, PubMed:37612506). The transmembrane long form (L-OPA1) and the S-OPA1 form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (PubMed:31922487, PubMed:32228866, PubMed:37612504, PubMed:37612506). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (PubMed:32228866, PubMed:37612504, PubMed:37612506). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (PubMed:37612504, PubMed:37612506). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:28628083, PubMed:37612504, PubMed:37612506). Excess levels of S-OPA1 produced by cleavage by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, thereby inhibiting mitochondrial fusion (PubMed:20038677). Involved in mitochondrial safeguard in response to transient mitochondrial membrane depolarization by mediating flickering: cleavage by OMA1 leads to excess production of S-OPA1, preventing mitochondrial hyperfusion (By similarity). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:32245890). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (By similarity). {ECO:0000250|UniProtKB:G0SGC7, ECO:0000250|UniProtKB:P58281, ECO:0000269|PubMed:20038677, ECO:0000269|PubMed:28628083, ECO:0000269|PubMed:31922487, ECO:0000269|PubMed:32228866, ECO:0000269|PubMed:32245890, ECO:0000269|PubMed:37612504, ECO:0000269|PubMed:37612506}.; FUNCTION: [Isoform 1]: Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion. {ECO:0000269|PubMed:17709429}.; FUNCTION: [Isoform 4]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. {ECO:0000269|PubMed:20974897}.; FUNCTION: [Isoform 5]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. {ECO:0000269|PubMed:20974897}.
O60356 NUPR1 S58 ochoa Nuclear protein 1 (Candidate of metastasis 1) (Protein p8) Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11056169, PubMed:11940591, PubMed:16300740, PubMed:16478804, PubMed:18690848, PubMed:19650074, PubMed:19723804, PubMed:20181828, PubMed:22565310, PubMed:22858377, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). {ECO:0000250|UniProtKB:O54842, ECO:0000250|UniProtKB:Q9WTK0, ECO:0000269|PubMed:11056169, ECO:0000269|PubMed:11940591, ECO:0000269|PubMed:16300740, ECO:0000269|PubMed:16478804, ECO:0000269|PubMed:18690848, ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:19723804, ECO:0000269|PubMed:20181828, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377, ECO:0000269|PubMed:30451898}.
O60563 CCNT1 S22 ochoa Cyclin-T1 (CycT1) (Cyclin-T) Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}.
O60711 LPXN S267 ochoa Leupaxin Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}.
O60716 CTNND1 S651 ochoa Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}.
O75044 SRGAP2 S916 ochoa SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}.
O75420 GIGYF1 S148 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O75420 GIGYF1 S230 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O75616 ERAL1 S173 ochoa|psp GTPase Era, mitochondrial (H-ERA) (hERA) (Conserved ERA-like GTPase) (CEGA) (ERA-W) (ERA-like protein 1) Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. {ECO:0000269|PubMed:20430825, ECO:0000269|PubMed:20604745, ECO:0000269|PubMed:28449065}.
O94762 RECQL5 S815 ochoa ATP-dependent DNA helicase Q5 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ5) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5) DNA helicase that plays an important role in DNA replication, transcription and repair (PubMed:20643585, PubMed:22973052, PubMed:28100692). Probably unwinds DNA in a 3'-5' direction (Probable) (PubMed:28100692). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability (PubMed:20231364). Also associates with POLR1A and enforces the stability of ribosomal DNA arrays (PubMed:27502483). Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress (PubMed:22013166). Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis (PubMed:28575661). Required for efficient DNA repair, including repair of inter-strand cross-links (PubMed:23715498). Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. A core helicase fragment (residues 11-609) binds preferentially to splayed duplex, looped and ssDNA (PubMed:28100692). {ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20643585, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22973052, ECO:0000269|PubMed:23715498, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:27502483, ECO:0000269|PubMed:28100692, ECO:0000269|PubMed:28575661, ECO:0000305|PubMed:28100692}.
O94842 TOX4 S178 ochoa TOX high mobility group box family member 4 Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (By similarity). This regulation is independent of the insulin receptor activation (By similarity). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:39603239, PubMed:39603240). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:39603239, PubMed:39603240). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). {ECO:0000250|UniProtKB:Q8BU11, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.
O94900 TOX S216 ochoa Thymocyte selection-associated high mobility group box protein TOX (Thymus high mobility group box protein TOX) Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (By similarity) (PubMed:21126536). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (By similarity). {ECO:0000250|UniProtKB:Q66JW3, ECO:0000269|PubMed:21126536}.
O95279 KCNK5 S385 ochoa Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:26919430, PubMed:36063992, PubMed:9812978). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). {ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:36063992, ECO:0000269|PubMed:9812978}.
O95936 EOMES S596 ochoa Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2) Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017, ECO:0000269|PubMed:33488348}.
O95985 TOP3B S788 ochoa DNA topoisomerase 3-beta-1 (EC 5.6.2.1) (DNA topoisomerase III beta-1) Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity. {ECO:0000250}.
P04049 RAF1 S29 ochoa|psp RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P04626 ERBB2 S1107 ochoa Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}.
P06239 LCK S194 ochoa|psp Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}.
P06241 FYN Y39 psp Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}.
P08237 PFKM S667 ochoa ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
P0C7T5 ATXN1L S289 ochoa Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}.
P0CG12 DERPC S302 ochoa Decreased expression in renal and prostate cancer protein Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}.
P10636 MAPT S46 ochoa Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P11021 HSPA5 T62 psp Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}.
P11172 UMPS S214 ochoa|psp Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)] Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP). {ECO:0000269|PubMed:18184586, ECO:0000269|PubMed:9042911}.
P11308 ERG S96 psp Transcriptional regulator ERG (Transforming protein ERG) Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
P13631 RARG S36 ochoa Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250}.
P14868 DARS1 S249 ochoa Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein) Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000250|UniProtKB:P15178}.
P15884 TCF4 S66 ochoa Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}.
P18669 PGAM1 S31 ochoa Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202). {ECO:0000269|PubMed:23653202}.
P21333 FLNA S1923 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S2615 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P27987 ITPKB S544 ochoa Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}.
P29317 EPHA2 S277 psp Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}.
P31269 HOXA9 S161 ochoa Homeobox protein Hox-A9 (Homeobox protein Hox-1G) Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed:22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity). {ECO:0000250|UniProtKB:P09631, ECO:0000269|PubMed:22269951}.
P33993 MCM7 S365 psp DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
P35568 IRS1 S616 ochoa|psp Insulin receptor substrate 1 (IRS-1) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}.
P42858 HTT S432 ochoa|psp Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}.
P43268 ETV4 S140 ochoa ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:8441666}.
P43405 SYK S307 ochoa Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}.
P46821 MAP1B S1076 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P49796 RGS3 S401 ochoa Regulator of G-protein signaling 3 (RGP3) (RGS3) Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}.
P50461 CSRP3 S95 ochoa Cysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein) Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). {ECO:0000250|UniProtKB:P50462, ECO:0000250|UniProtKB:P50463, ECO:0000269|PubMed:19752190, ECO:0000269|PubMed:24934443, ECO:0000269|PubMed:27353086}.; FUNCTION: [Isoform 2]: May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization. {ECO:0000269|PubMed:24860983}.
P50851 LRBA S979 ochoa Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}.
P51398 DAP3 S44 ochoa Small ribosomal subunit protein mS29 (EC 3.6.5.-) (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs (PubMed:39701103). Involved in mediating interferon-gamma-induced cell death (PubMed:7499268). Displays GTPase activity in vitro (PubMed:39701103). {ECO:0000269|PubMed:39701103, ECO:0000269|PubMed:7499268}.
P51610 HCFC1 S1222 ochoa Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}.
P52179 MYOM1 S1493 ochoa Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P52701 MSH6 S292 ochoa DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}.
P78312 FAM193A S985 ochoa Protein FAM193A (Protein IT14) None
P78344 EIF4G2 S395 ochoa Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}.
P78559 MAP1A S1288 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P82675 MRPS5 S386 ochoa Small ribosomal subunit protein uS5m (28S ribosomal protein S5, mitochondrial) (MRP-S5) (S5mt) None
P84550 SKOR1 S748 ochoa SKI family transcriptional corepressor 1 (Functional Smad-suppressing element on chromosome 15) (Fussel-15) (LBX1 corepressor 1) (Ladybird homeobox corepressor 1) Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling. {ECO:0000250}.
Q00587 CDC42EP1 S303 ochoa Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}.
Q00839 HNRNPU S799 ochoa Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}.
Q01101 INSM1 S101 ochoa Insulinoma-associated protein 1 (Zinc finger protein IA-1) Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (PubMed:23721412). Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation. {ECO:0000269|PubMed:11842116, ECO:0000269|PubMed:16511571, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:19124461, ECO:0000269|PubMed:23721412}.
Q08AN1 ZNF616 S177 ochoa Zinc finger protein 616 May be involved in transcriptional regulation.
Q09666 AHNAK S41 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q10571 MN1 S1007 ochoa Transcriptional activator MN1 (Probable tumor suppressor protein MN1) Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}.
Q12778 FOXO1 S249 psp Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}.
Q12778 FOXO1 S470 ochoa Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}.
Q13620 CUL4B S28 ochoa Cullin-4B (CUL-4B) Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:16322693, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18235224, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854239}.
Q14004 CDK13 S1483 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q14160 SCRIB S1140 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14315 FLNC S1637 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14684 RRP1B S706 ochoa|psp Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}.
Q14966 ZNF638 S605 ochoa Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}.
Q15349 RPS6KA2 S546 ochoa Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
Q15477 SKIC2 S1017 ochoa Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}.
Q16584 MAP3K11 S507 ochoa Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}.
Q16799 RTN1 S71 ochoa Reticulon-1 (Neuroendocrine-specific protein) Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}.
Q17R98 ZNF827 S518 ochoa Zinc finger protein 827 As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}.
Q2KJY2 KIF26B S1613 ochoa Kinesin-like protein KIF26B Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}.
Q504Q3 PAN2 S791 ochoa PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618, ECO:0000269|PubMed:23398456}.
Q5SYE7 NHSL1 S639 ochoa NHS-like protein 1 None
Q5TC12 ATPAF1 S40 ochoa ATP synthase mitochondrial F1 complex assembly factor 1 (ATP11 homolog) Has a complex stabilizing activity in the assembly of the mitochondrial F1-F0 complex. {ECO:0000250|UniProtKB:Q811I0}.
Q5VSL9 STRIP1 S65 ochoa Striatin-interacting protein 1 (Protein FAM40A) Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399}.
Q5VST9 OBSCN S6881 ochoa Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.
Q5VT25 CDC42BPA S1693 ochoa Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.
Q5VT97 SYDE2 S223 ochoa Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Q63HK5 TSHZ3 S682 ochoa Teashirt homolog 3 (Zinc finger protein 537) Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}.
Q66K89 E4F1 S318 ochoa Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F) May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.
Q68CZ2 TNS3 S901 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q6IE81 JADE1 S603 ochoa Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22654112, ECO:0000269|PubMed:24065767}.
Q6KC79 NIPBL S103 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q6NZY4 ZCCHC8 S658 ochoa Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}.
Q6P1R3 MSANTD2 S48 ochoa Myb/SANT-like DNA-binding domain-containing protein 2 None
Q6P996 PDXDC1 S757 ochoa Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) None
Q6PJ61 FBXO46 S240 ochoa F-box only protein 46 (F-box only protein 34-like) Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}.
Q6SZW1 SARM1 S54 ochoa NAD(+) hydrolase SARM1 (NADase SARM1) (hSARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and Armadillo repeat protein) (Sterile alpha and TIR motif-containing protein 1) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog) (HsTIR) NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439792, PubMed:31439793, PubMed:32049506, PubMed:32828421, PubMed:33053563). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). {ECO:0000250|UniProtKB:Q6PDS3, ECO:0000269|PubMed:15123841, ECO:0000269|PubMed:16964262, ECO:0000269|PubMed:20306472, ECO:0000269|PubMed:25908823, ECO:0000269|PubMed:27671644, ECO:0000269|PubMed:28334607, ECO:0000269|PubMed:29395922, ECO:0000269|PubMed:30333228, ECO:0000269|PubMed:31128467, ECO:0000269|PubMed:31439792, ECO:0000269|PubMed:31439793, ECO:0000269|PubMed:32049506, ECO:0000269|PubMed:32828421, ECO:0000269|PubMed:33053563}.
Q6WKZ4 RAB11FIP1 S1214 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6ZMB5 TMEM184A S368 ochoa Transmembrane protein 184A Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity). {ECO:0000250|UniProtKB:Q3UFJ6, ECO:0000250|UniProtKB:Q4QQS1}.
Q6ZNH5 ZNF497 S98 ochoa Zinc finger protein 497 May be involved in transcriptional regulation.
Q6ZUT6 CCDC9B S55 ochoa Coiled-coil domain-containing protein 9B None
Q6ZUT6 CCDC9B S193 ochoa Coiled-coil domain-containing protein 9B None
Q6ZVH7 ESPNL S635 ochoa Espin-like protein Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}.
Q702N8 XIRP1 S481 ochoa Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}.
Q70EL1 USP54 S1036 ochoa Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}.
Q71F56 MED13L S1081 ochoa Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
Q76I76 SSH2 S1283 ochoa Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}.
Q7KZI7 MARK2 S619 ochoa|psp Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Q7Z4K8 TRIM46 S627 ochoa Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein) Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration. {ECO:0000250|UniProtKB:Q7TNM2}.
Q7Z6B7 SRGAP1 S886 ochoa SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}.
Q86U70 LDB1 S323 ochoa LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}.
Q86US8 SMG6 S203 ochoa Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}.
Q8IVJ1 SLC41A1 S89 ochoa Solute carrier family 41 member 1 Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (PubMed:22031603, PubMed:23661805). Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). {ECO:0000250|UniProtKB:Q8BJA2, ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:22031603, ECO:0000269|PubMed:23661805, ECO:0000269|PubMed:23976986, ECO:0000269|PubMed:27074515}.
Q8IVL1 NAV2 S1559 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IWQ3 BRSK2 S393 ochoa Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}.
Q8IZC7 ZNF101 S152 ochoa Zinc finger protein 101 (Zinc finger protein HZF12) May be involved in transcriptional regulation.
Q8N1G0 ZNF687 S1146 ochoa Zinc finger protein 687 May be involved in transcriptional regulation.
Q8N1G1 REXO1 S422 ochoa RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}.
Q8N2Y8 RUSC2 S574 ochoa AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}.
Q8N350 CBARP S304 ochoa Voltage-dependent calcium channel beta subunit-associated regulatory protein Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}.
Q8N3K9 CMYA5 S168 ochoa Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}.
Q8N594 MPND S123 ochoa MPN domain-containing protein (EC 3.4.-.-) Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (PubMed:30982744). Binds only double strand DNA (dsDNA) in a sequence-independent manner (By similarity). {ECO:0000250|UniProtKB:Q3TV65, ECO:0000250|UniProtKB:Q5VVJ2, ECO:0000269|PubMed:30982744}.
Q8N5C8 TAB3 S80 ochoa TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}.
Q8NCE0 TSEN2 S215 ochoa tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2) Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity. {ECO:0000269|PubMed:15109492}.
Q8TB72 PUM2 S136 ochoa Pumilio homolog 2 (Pumilio-2) Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}.
Q8TEQ6 GEMIN5 S48 ochoa Gem-associated protein 5 (Gemin5) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}.
Q8TF30 WHAMM S181 ochoa WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1) Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. {ECO:0000269|PubMed:18614018, ECO:0000269|PubMed:23027905, ECO:0000269|PubMed:23087206}.
Q8WVV9 HNRNPLL S75 ochoa Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}.
Q92576 PHF3 S1642 ochoa PHD finger protein 3 None
Q92585 MAML1 S120 ochoa Mastermind-like protein 1 (Mam-1) Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.
Q92610 ZNF592 S1089 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q92871 PMM1 S242 ochoa Phosphomannomutase 1 (PMM 1) (EC 5.4.2.8) (PMMH-22) Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:16540464}.
Q96E09 PABIR1 S48 ochoa PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}.
Q96HI0 SENP5 S465 ochoa Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}.
Q96HU1 SGSM3 S65 ochoa Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP) May play a cooperative role in NF2-mediated growth suppression of cells. {ECO:0000269|PubMed:15541357}.
Q96K76 USP47 S910 ochoa Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}.
Q96KS0 EGLN2 S130 ochoa|psp Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}.
Q96L73 NSD1 S979 ochoa Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}.
Q96PV7 FAM193B S730 ochoa Protein FAM193B None
Q96R06 SPAG5 S341 ochoa Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}.
Q96RU3 FNBP1 S517 ochoa Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}.
Q99612 KLF6 S192 ochoa Krueppel-like factor 6 (B-cell-derived protein 1) (Core promoter element-binding protein) (GC-rich sites-binding factor GBF) (Proto-oncogene BCD1) (Suppressor of tumorigenicity 12 protein) (Transcription factor Zf9) Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development. {ECO:0000250}.
Q9BQ75 CMSS1 S228 ochoa Protein CMSS1 (Cms1 ribosomal small subunit homolog) None
Q9BTX1 NDC1 S471 ochoa Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}.
Q9BTX1 NDC1 S500 ochoa Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}.
Q9BVI0 PHF20 S880 ochoa PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}.
Q9BWE0 REPIN1 S27 ochoa DNA-binding protein REPIN1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464) Sequence-specific double-stranded DNA-binding protein (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity). {ECO:0000250|UniProtKB:Q5U4E2, ECO:0000269|PubMed:10606657, ECO:0000269|PubMed:11328883, ECO:0000269|PubMed:2174103, ECO:0000269|PubMed:2247056, ECO:0000269|PubMed:8355269}.
Q9BX95 SGPP1 S101 ochoa Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1) Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:11756451, PubMed:12815058, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (PubMed:16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:18583713, PubMed:20798685). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q9JI99, ECO:0000269|PubMed:11756451, ECO:0000269|PubMed:12815058, ECO:0000269|PubMed:16782891, ECO:0000269|PubMed:18583713, ECO:0000269|PubMed:20798685}.
Q9C0B5 ZDHHC5 S247 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9C0H5 ARHGAP39 S432 ochoa Rho GTPase-activating protein 39 None
Q9C0K0 BCL11B S788 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9GZU1 MCOLN1 S547 ochoa Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:18794901, PubMed:25720963, PubMed:27623384, PubMed:29019983). Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:25720963, PubMed:29019983). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:25720963, PubMed:27623384, PubMed:29019983). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25720963, PubMed:25733853, PubMed:27787197). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Also functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Also permeable to Mg(2+), Na(+). K(+) and Cs(+) (By similarity). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). {ECO:0000250|UniProtKB:Q99J21, ECO:0000269|PubMed:12459486, ECO:0000269|PubMed:14749347, ECO:0000269|PubMed:15336987, ECO:0000269|PubMed:16978393, ECO:0000269|PubMed:18794901, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:25733853, ECO:0000269|PubMed:27357649, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:27787197, ECO:0000269|PubMed:29019983, ECO:0000305|PubMed:11013137}.; FUNCTION: May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase. {ECO:0000305|PubMed:21256127}.
Q9H008 LHPP S241 ochoa Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (hLHPP) (EC 3.1.3.-) (EC 3.6.1.1) Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). {ECO:0000250}.
Q9H0W5 CCDC8 S261 ochoa|psp Coiled-coil domain-containing protein 8 Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). {ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.
Q9H165 BCL11A S734 ochoa BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}.
Q9H2M9 RAB3GAP2 S450 ochoa Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}.
Q9H8Y5 ANKZF1 S56 ochoa tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744) Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:29632312, PubMed:30244831, PubMed:31011209). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:29632312, PubMed:30244831, PubMed:31011209). ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209). ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755). Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). {ECO:0000269|PubMed:28302725, ECO:0000269|PubMed:29632312, ECO:0000269|PubMed:30244831, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:32075755}.
Q9HAK2 EBF2 S161 ochoa Transcription factor COE2 (Early B-cell factor 2) (EBF-2) Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). {ECO:0000250}.
Q9HB58 SP110 S380 ochoa Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Q9HBE1 PATZ1 S282 ochoa POZ-, AT hook-, and zinc finger-containing protein 1 (BTB/POZ domain zinc finger transcription factor) (Protein kinase A RI subunit alpha-associated protein) (Zinc finger and BTB domain-containing protein 19) (Zinc finger protein 278) (Zinc finger sarcoma gene protein) Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552). {ECO:0000269|PubMed:10713105, ECO:0000269|PubMed:25755280, ECO:0000269|PubMed:31875552}.; FUNCTION: (Microbial infection) Plays a positive role in viral cDNA synthesis. {ECO:0000269|PubMed:31060775}.
Q9NP66 HMG20A S105 ochoa High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1) Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). {ECO:0000250}.
Q9NQL9 DMRT3 S180 ochoa Doublesex- and mab-3-related transcription factor 3 Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity). {ECO:0000250}.
Q9NR19 ACSS2 S30 ochoa Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17) Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429, PubMed:28552616). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis (PubMed:28552616). Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription (PubMed:28552616). The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival (PubMed:28552616). Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory (By similarity). {ECO:0000250|UniProtKB:Q9QXG4, ECO:0000269|PubMed:10843999, ECO:0000269|PubMed:28003429, ECO:0000269|PubMed:28552616}.
Q9NRG9 AAAS S33 ochoa Aladin (Adracalin) Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606). {ECO:0000269|PubMed:11062474, ECO:0000269|PubMed:11159947, ECO:0000269|PubMed:16022285, ECO:0000269|PubMed:26246606}.
Q9NS62 THSD1 S619 ochoa Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module) Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. {ECO:0000269|PubMed:27895300, ECO:0000269|PubMed:29069646}.
Q9NWH9 SLTM S553 ochoa SAFB-like transcription modulator (Modulator of estrogen-induced transcription) When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.
Q9NZ56 FMN2 S516 ochoa Formin-2 Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}.
Q9NZM1 MYOF S963 ochoa Myoferlin (Fer-1-like protein 3) Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}.
Q9P0L2 MARK1 S403 ochoa Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}.
Q9P1Y5 CAMSAP3 S1031 ochoa Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.
Q9P1Y6 PHRF1 S814 ochoa PHD and RING finger domain-containing protein 1 None
Q9P202 WHRN S245 ochoa Whirlin (Autosomal recessive deafness type 31 protein) Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. {ECO:0000250|UniProtKB:Q80VW5}.
Q9P227 ARHGAP23 S517 ochoa Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Q9P286 PAK5 S277 ochoa Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}.
Q9P2E9 RRBP1 S533 ochoa Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.
Q9P2F8 SIPA1L2 S379 ochoa Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) None
Q9UBB5 MBD2 S44 ochoa Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568). {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}.
Q9UG56 PISD S341 ochoa Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain] Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) (PubMed:30488656, PubMed:30858161). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity). {ECO:0000250|UniProtKB:A0A8H4BVL9, ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:30488656, ECO:0000269|PubMed:30858161}.
Q9UGL1 KDM5B S1328 ochoa|psp Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}.
Q9UGU0 TCF20 S31 ochoa Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}.
Q9UHB7 AFF4 S549 ochoa AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Q9UIW0 VAX2 S42 ochoa Ventral anterior homeobox 2 Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. {ECO:0000250}.
Q9UKX7 NUP50 S221 ochoa|psp Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}.
Q9ULD4 BRPF3 S943 ochoa Bromodomain and PHD finger-containing protein 3 Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}.
Q9ULM0 PLEKHH1 S324 ochoa Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) None
Q9UNH5 CDC14A S411 psp Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}.
Q9UPP1 PHF8 S804 ochoa Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}.
Q9UPQ9 TNRC6B S803 ochoa Trinucleotide repeat-containing gene 6B protein Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}.
Q9UPR0 PLCL2 S71 ochoa Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}.
Q9Y2L8 ZKSCAN5 S335 ochoa Zinc finger protein with KRAB and SCAN domains 5 (Zinc finger protein 95 homolog) (Zfp-95) May be involved in transcriptional regulation.
Q9Y2U5 MAP3K2 S349 ochoa Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}.
Q9Y320 TMX2 S211 ochoa Thioredoxin-related transmembrane protein 2 (Cell proliferation-inducing gene 26 protein) (Thioredoxin domain-containing protein 14) Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain. {ECO:0000269|PubMed:31735293}.
Q9Y467 SALL2 S684 ochoa Sal-like protein 2 (Zinc finger protein 795) (Zinc finger protein SALL2) (Zinc finger protein Spalt-2) (Sal-2) (hSal2) Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure. {ECO:0000269|PubMed:24412933}.
Q9Y4F9 RIPOR2 S730 ochoa Rho family-interacting cell polarization regulator 2 Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:23241886, PubMed:24687993, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). {ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:24958875, ECO:0000269|PubMed:27556504}.; FUNCTION: [Isoform 2]: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504). {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:25588844, ECO:0000269|PubMed:27556504}.
Q9Y4H2 IRS2 S1162 ochoa Insulin receptor substrate 2 (IRS-2) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}.
Q9Y570 PPME1 S42 ochoa Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}.
Q9Y6F1 PARP3 S461 psp Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (hPARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3) Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:16924674, PubMed:19354255, PubMed:20064938, PubMed:21211721, PubMed:21270334, PubMed:23742272, PubMed:24598253, PubMed:25043379, PubMed:28447610). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (PubMed:20064938, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6 (PubMed:16924674, PubMed:24598253). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA (PubMed:27530147). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ (PubMed:24598253). Suppresses G-quadruplex (G4) structures in response to DNA damage (PubMed:28447610). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (PubMed:16924674). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (PubMed:29361132, PubMed:29520010). {ECO:0000250|UniProtKB:Q3ULW8, ECO:0000269|PubMed:16924674, ECO:0000269|PubMed:19354255, ECO:0000269|PubMed:20064938, ECO:0000269|PubMed:21211721, ECO:0000269|PubMed:21270334, ECO:0000269|PubMed:23742272, ECO:0000269|PubMed:24598253, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:27530147, ECO:0000269|PubMed:28447610, ECO:0000269|PubMed:29361132, ECO:0000269|PubMed:29520010}.
O14976 GAK S399 Sugiyama Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}.
P11142 HSPA8 T38 Sugiyama Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}.
P34931 HSPA1L T40 Sugiyama Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}.
P54652 HSPA2 T39 Sugiyama Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}.
Q8NBJ7 SUMF2 S44 Sugiyama Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010}.
Q9BZK7 TBL1XR1 S451 Sugiyama F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. {ECO:0000269|PubMed:14980219}.
P17066 HSPA6 T40 Sugiyama Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}.
P48741 HSPA7 T40 Sugiyama Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) None
P62714 PPP2CB S212 Sugiyama Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}.
P67775 PPP2CA S212 Sugiyama Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}.
O00469 PLOD2 S441 Sugiyama Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2) Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. {ECO:0000250|UniProtKB:P24802}.
Q02750 MAP2K1 S244 SIGNOR Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}.
P51451 BLK S190 Sugiyama Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Also phosphorylates the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Also contributes to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214). {ECO:0000250|UniProtKB:P16277, ECO:0000269|PubMed:19667185, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:8756631}.
P23284 PPIB S139 Sugiyama Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269|PubMed:20676357}.
P78368 CSNK1G2 S27 Sugiyama Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:Q8BVP5, ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:19005213, ECO:0000269|PubMed:37099597}.
Q01813 PFKP S679 SIGNOR ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Q8WVV9 HNRNPLL S86 Sugiyama Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}.
P50895 BCAM S298 Sugiyama Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239) Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion (PubMed:9616226, PubMed:31413112). Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction (PubMed:17158232). Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion (PubMed:15975931). Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR (PubMed:23160466). {ECO:0000269|PubMed:15975931, ECO:0000269|PubMed:17158232, ECO:0000269|PubMed:23160466, ECO:0000269|PubMed:31413112, ECO:0000269|PubMed:9616226}.
P62714 PPP2CB S75 Sugiyama Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}.
P67775 PPP2CA S75 Sugiyama Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}.
Q96PY6 NEK1 S436 Sugiyama Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}.
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reactome_id name p -log10_p
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 3.238841e-09 8.490
R-HSA-3371556 Cellular response to heat stress 2.915565e-08 7.535
R-HSA-3371568 Attenuation phase 7.935378e-07 6.100
R-HSA-3371571 HSF1-dependent transactivation 4.189208e-06 5.378
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 1.590958e-05 4.798
R-HSA-428543 Inactivation of CDC42 and RAC1 3.852518e-05 4.414
R-HSA-9706374 FLT3 signaling through SRC family kinases 1.156662e-04 3.937
R-HSA-70171 Glycolysis 3.363778e-04 3.473
R-HSA-5673000 RAF activation 4.471253e-04 3.350
R-HSA-3371511 HSF1 activation 5.536741e-04 3.257
R-HSA-913531 Interferon Signaling 5.158947e-04 3.287
R-HSA-389513 Co-inhibition by CTLA4 6.223495e-04 3.206
R-HSA-70326 Glucose metabolism 9.796626e-04 3.009
R-HSA-68875 Mitotic Prophase 1.129993e-03 2.947
R-HSA-5683057 MAPK family signaling cascades 1.615458e-03 2.792
R-HSA-9833482 PKR-mediated signaling 2.433993e-03 2.614
R-HSA-6804757 Regulation of TP53 Degradation 4.409909e-03 2.356
R-HSA-450294 MAP kinase activation 4.296073e-03 2.367
R-HSA-74713 IRS activation 5.224202e-03 2.282
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 5.287091e-03 2.277
R-HSA-5674499 Negative feedback regulation of MAPK pathway 6.756043e-03 2.170
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 5.224202e-03 2.282
R-HSA-199418 Negative regulation of the PI3K/AKT network 7.115439e-03 2.148
R-HSA-6806003 Regulation of TP53 Expression and Degradation 5.576763e-03 2.254
R-HSA-5675221 Negative regulation of MAPK pathway 6.933526e-03 2.159
R-HSA-198753 ERK/MAPK targets 7.538689e-03 2.123
R-HSA-448424 Interleukin-17 signaling 7.114692e-03 2.148
R-HSA-164944 Nef and signal transduction 8.466255e-03 2.072
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 8.265654e-03 2.083
R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 8.466255e-03 2.072
R-HSA-4839726 Chromatin organization 8.595001e-03 2.066
R-HSA-1169408 ISG15 antiviral mechanism 9.140176e-03 2.039
R-HSA-1280215 Cytokine Signaling in Immune system 9.007843e-03 2.045
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 9.398262e-03 2.027
R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors 1.034917e-02 1.985
R-HSA-112412 SOS-mediated signalling 1.034917e-02 1.985
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 1.949901e-02 1.710
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 1.949901e-02 1.710
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 1.949901e-02 1.710
R-HSA-5339716 Signaling by GSK3beta mutants 2.216487e-02 1.654
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 2.497205e-02 1.603
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 2.497205e-02 1.603
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 2.497205e-02 1.603
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 2.497205e-02 1.603
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 2.497205e-02 1.603
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 1.793246e-02 1.746
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 1.925722e-02 1.715
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 1.925722e-02 1.715
R-HSA-1855170 IPs transport between nucleus and cytosol 2.206511e-02 1.656
R-HSA-159227 Transport of the SLBP independent Mature mRNA 2.206511e-02 1.656
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.354831e-02 1.628
R-HSA-191859 snRNP Assembly 1.967414e-02 1.706
R-HSA-194441 Metabolism of non-coding RNA 1.967414e-02 1.706
R-HSA-198203 PI3K/AKT activation 1.697940e-02 1.770
R-HSA-2424491 DAP12 signaling 1.793246e-02 1.746
R-HSA-389356 Co-stimulation by CD28 1.090419e-02 1.962
R-HSA-4791275 Signaling by WNT in cancer 2.063475e-02 1.685
R-HSA-4839744 Signaling by APC mutants 1.949901e-02 1.710
R-HSA-202670 ERKs are inactivated 2.216487e-02 1.654
R-HSA-4839748 Signaling by AMER1 mutants 2.216487e-02 1.654
R-HSA-4839735 Signaling by AXIN mutants 2.216487e-02 1.654
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 2.195883e-02 1.658
R-HSA-74749 Signal attenuation 1.697940e-02 1.770
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 1.427342e-02 1.845
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.354831e-02 1.628
R-HSA-5684996 MAPK1/MAPK3 signaling 2.352666e-02 1.628
R-HSA-5673001 RAF/MAP kinase cascade 2.056730e-02 1.687
R-HSA-9022692 Regulation of MECP2 expression and activity 2.206511e-02 1.656
R-HSA-430116 GP1b-IX-V activation signalling 1.461109e-02 1.835
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 2.216487e-02 1.654
R-HSA-180746 Nuclear import of Rev protein 2.508434e-02 1.601
R-HSA-6784531 tRNA processing in the nucleus 2.264543e-02 1.645
R-HSA-422475 Axon guidance 1.329633e-02 1.876
R-HSA-2465910 MASTL Facilitates Mitotic Progression 1.461109e-02 1.835
R-HSA-428540 Activation of RAC1 2.216487e-02 1.654
R-HSA-9675108 Nervous system development 2.249648e-02 1.648
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 2.216487e-02 1.654
R-HSA-186712 Regulation of beta-cell development 1.967414e-02 1.706
R-HSA-166166 MyD88-independent TLR4 cascade 1.136111e-02 1.945
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 1.666034e-02 1.778
R-HSA-162909 Host Interactions of HIV factors 1.956490e-02 1.709
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 1.136111e-02 1.945
R-HSA-9020558 Interleukin-2 signaling 1.949901e-02 1.710
R-HSA-376176 Signaling by ROBO receptors 2.100241e-02 1.678
R-HSA-210990 PECAM1 interactions 1.949901e-02 1.710
R-HSA-166520 Signaling by NTRKs 1.410850e-02 1.851
R-HSA-187037 Signaling by NTRK1 (TRKA) 2.278928e-02 1.642
R-HSA-2586552 Signaling by Leptin 1.697940e-02 1.770
R-HSA-2219528 PI3K/AKT Signaling in Cancer 1.612470e-02 1.793
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 2.206511e-02 1.656
R-HSA-975871 MyD88 cascade initiated on plasma membrane 2.616589e-02 1.582
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 2.616589e-02 1.582
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 2.616589e-02 1.582
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 2.667314e-02 1.574
R-HSA-389359 CD28 dependent Vav1 pathway 2.791574e-02 1.554
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 2.791574e-02 1.554
R-HSA-114604 GPVI-mediated activation cascade 2.831462e-02 1.548
R-HSA-5632968 Defective Mismatch Repair Associated With MSH6 2.985215e-02 1.525
R-HSA-196299 Beta-catenin phosphorylation cascade 3.419393e-02 1.466
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 3.355359e-02 1.474
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 3.419393e-02 1.466
R-HSA-1295596 Spry regulation of FGF signaling 3.419393e-02 1.466
R-HSA-180910 Vpr-mediated nuclear import of PICs 3.000863e-02 1.523
R-HSA-1433559 Regulation of KIT signaling 3.099123e-02 1.509
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 3.419393e-02 1.466
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 3.175502e-02 1.498
R-HSA-168276 NS1 Mediated Effects on Host Pathways 3.355359e-02 1.474
R-HSA-446353 Cell-extracellular matrix interactions 3.419393e-02 1.466
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 3.540409e-02 1.451
R-HSA-177243 Interactions of Rev with host cellular proteins 3.540409e-02 1.451
R-HSA-176033 Interactions of Vpr with host cellular proteins 3.540409e-02 1.451
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 3.714167e-02 1.430
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 3.730628e-02 1.428
R-HSA-9607240 FLT3 Signaling 3.730628e-02 1.428
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 3.751934e-02 1.426
R-HSA-975155 MyD88 dependent cascade initiated on endosome 3.826010e-02 1.417
R-HSA-176034 Interactions of Tat with host cellular proteins 4.444371e-02 1.352
R-HSA-5339700 Signaling by TCF7L2 mutants 4.444371e-02 1.352
R-HSA-9649948 Signaling downstream of RAS mutants 4.978647e-02 1.303
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 4.978647e-02 1.303
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 4.978647e-02 1.303
R-HSA-6802949 Signaling by RAS mutants 4.978647e-02 1.303
R-HSA-5632928 Defective Mismatch Repair Associated With MSH2 4.444371e-02 1.352
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 4.758125e-02 1.323
R-HSA-2172127 DAP12 interactions 4.542557e-02 1.343
R-HSA-2299718 Condensation of Prophase Chromosomes 4.978647e-02 1.303
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 4.978647e-02 1.303
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 4.217967e-02 1.375
R-HSA-3247509 Chromatin modifying enzymes 4.131298e-02 1.384
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 4.293867e-02 1.367
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 4.666406e-02 1.331
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 4.542557e-02 1.343
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 4.096309e-02 1.388
R-HSA-432142 Platelet sensitization by LDL 4.818858e-02 1.317
R-HSA-9754189 Germ layer formation at gastrulation 5.196206e-02 1.284
R-HSA-912631 Regulation of signaling by CBL 5.196206e-02 1.284
R-HSA-113510 E2F mediated regulation of DNA replication 5.196206e-02 1.284
R-HSA-1257604 PIP3 activates AKT signaling 5.248435e-02 1.280
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 5.328790e-02 1.273
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 5.328790e-02 1.273
R-HSA-5687128 MAPK6/MAPK4 signaling 5.424042e-02 1.266
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 5.583735e-02 1.253
R-HSA-9823730 Formation of definitive endoderm 5.583735e-02 1.253
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 5.751173e-02 1.240
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 5.751173e-02 1.240
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 5.881669e-02 1.230
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 5.881669e-02 1.230
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 5.881669e-02 1.230
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 5.881669e-02 1.230
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 5.881669e-02 1.230
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 5.881669e-02 1.230
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 5.881669e-02 1.230
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 5.881669e-02 1.230
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 5.881669e-02 1.230
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 5.881669e-02 1.230
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 5.881669e-02 1.230
R-HSA-8874177 ATF6B (ATF6-beta) activates chaperones 5.881669e-02 1.230
R-HSA-350054 Notch-HLH transcription pathway 6.803572e-02 1.167
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 6.803572e-02 1.167
R-HSA-429947 Deadenylation of mRNA 7.660821e-02 1.116
R-HSA-9839394 TGFBR3 expression 8.101595e-02 1.091
R-HSA-9843745 Adipogenesis 7.459425e-02 1.127
R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... 6.803572e-02 1.167
R-HSA-432722 Golgi Associated Vesicle Biogenesis 6.657070e-02 1.177
R-HSA-8875513 MET interacts with TNS proteins 7.297435e-02 1.137
R-HSA-429914 Deadenylation-dependent mRNA decay 8.273713e-02 1.082
R-HSA-5423599 Diseases of Mismatch Repair (MMR) 7.297435e-02 1.137
R-HSA-3214842 HDMs demethylate histones 8.101595e-02 1.091
R-HSA-5621575 CD209 (DC-SIGN) signaling 7.660821e-02 1.116
R-HSA-9669938 Signaling by KIT in disease 6.803572e-02 1.167
R-HSA-2980766 Nuclear Envelope Breakdown 7.717425e-02 1.113
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 7.228032e-02 1.141
R-HSA-9932451 SWI/SNF chromatin remodelers 8.101595e-02 1.091
R-HSA-9932444 ATP-dependent chromatin remodelers 8.101595e-02 1.091
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 7.445717e-02 1.128
R-HSA-1266695 Interleukin-7 signaling 8.101595e-02 1.091
R-HSA-982772 Growth hormone receptor signaling 7.228032e-02 1.141
R-HSA-211163 AKT-mediated inactivation of FOXO1A 8.691991e-02 1.061
R-HSA-1251932 PLCG1 events in ERBB2 signaling 8.691991e-02 1.061
R-HSA-1306955 GRB7 events in ERBB2 signaling 8.691991e-02 1.061
R-HSA-9652169 Signaling by MAP2K mutants 8.691991e-02 1.061
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 8.691991e-02 1.061
R-HSA-3214847 HATs acetylate histones 8.761501e-02 1.057
R-HSA-168325 Viral Messenger RNA Synthesis 8.846741e-02 1.053
R-HSA-3928663 EPHA-mediated growth cone collapse 9.005762e-02 1.045
R-HSA-389357 CD28 dependent PI3K/Akt signaling 9.005762e-02 1.045
R-HSA-5654732 Negative regulation of FGFR3 signaling 9.468509e-02 1.024
R-HSA-9032759 NTRK2 activates RAC1 1.006565e-01 0.997
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 1.141873e-01 0.942
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 1.141873e-01 0.942
R-HSA-9027283 Erythropoietin activates STAT5 1.275154e-01 0.894
R-HSA-8951430 RUNX3 regulates WNT signaling 1.406437e-01 0.852
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 1.406437e-01 0.852
R-HSA-9732724 IFNG signaling activates MAPKs 1.406437e-01 0.852
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 1.406437e-01 0.852
R-HSA-9032500 Activated NTRK2 signals through FYN 1.535752e-01 0.814
R-HSA-444257 RSK activation 1.535752e-01 0.814
R-HSA-9660537 Signaling by MRAS-complex mutants 1.535752e-01 0.814
R-HSA-9768778 Regulation of NPAS4 mRNA translation 1.535752e-01 0.814
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 1.535752e-01 0.814
R-HSA-9613354 Lipophagy 1.663130e-01 0.779
R-HSA-9700645 ALK mutants bind TKIs 1.663130e-01 0.779
R-HSA-110056 MAPK3 (ERK1) activation 1.788599e-01 0.747
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 1.788599e-01 0.747
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 1.912186e-01 0.718
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 2.153832e-01 0.667
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 2.153832e-01 0.667
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 2.153832e-01 0.667
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 2.153832e-01 0.667
R-HSA-399956 CRMPs in Sema3A signaling 2.388286e-01 0.622
R-HSA-8847993 ERBB2 Activates PTK6 Signaling 2.388286e-01 0.622
R-HSA-1663150 The activation of arylsulfatases 2.388286e-01 0.622
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 2.502884e-01 0.602
R-HSA-9027284 Erythropoietin activates RAS 2.502884e-01 0.602
R-HSA-6785631 ERBB2 Regulates Cell Motility 2.502884e-01 0.602
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 1.187664e-01 0.925
R-HSA-1963640 GRB2 events in ERBB2 signaling 2.726949e-01 0.564
R-HSA-1963642 PI3K events in ERBB2 signaling 2.836468e-01 0.547
R-HSA-9665348 Signaling by ERBB2 ECD mutants 2.944345e-01 0.531
R-HSA-5674135 MAP2K and MAPK activation 1.705552e-01 0.768
R-HSA-9656223 Signaling by RAF1 mutants 1.705552e-01 0.768
R-HSA-112382 Formation of RNA Pol II elongation complex 2.308038e-01 0.637
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 2.642635e-01 0.578
R-HSA-5419276 Mitochondrial translation termination 2.781807e-01 0.556
R-HSA-927802 Nonsense-Mediated Decay (NMD) 2.904600e-01 0.537
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 2.904600e-01 0.537
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 1.598972e-01 0.796
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 1.598972e-01 0.796
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 1.573793e-01 0.803
R-HSA-3928664 Ephrin signaling 2.944345e-01 0.531
R-HSA-6802957 Oncogenic MAPK signaling 1.683081e-01 0.774
R-HSA-1227986 Signaling by ERBB2 2.754339e-01 0.560
R-HSA-9762292 Regulation of CDH11 function 1.788599e-01 0.747
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 1.912186e-01 0.718
R-HSA-9614657 FOXO-mediated transcription of cell death genes 2.944345e-01 0.531
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 2.615763e-01 0.582
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 1.260660e-01 0.899
R-HSA-5368286 Mitochondrial translation initiation 2.297516e-01 0.639
R-HSA-9609690 HCMV Early Events 2.288430e-01 0.640
R-HSA-195253 Degradation of beta-catenin by the destruction complex 1.161833e-01 0.935
R-HSA-8941856 RUNX3 regulates NOTCH signaling 2.153832e-01 0.667
R-HSA-4641265 Repression of WNT target genes 2.153832e-01 0.667
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 2.836468e-01 0.547
R-HSA-426496 Post-transcriptional silencing by small RNAs 1.006565e-01 0.997
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 2.388286e-01 0.622
R-HSA-418885 DCC mediated attractive signaling 2.502884e-01 0.602
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 1.441625e-01 0.841
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 1.759282e-01 0.755
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 2.031516e-01 0.692
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 2.141733e-01 0.669
R-HSA-75955 RNA Polymerase II Transcription Elongation 2.363670e-01 0.626
R-HSA-5389840 Mitochondrial translation elongation 2.218341e-01 0.654
R-HSA-174577 Activation of C3 and C5 1.006565e-01 0.997
R-HSA-9614399 Regulation of localization of FOXO transcription factors 1.912186e-01 0.718
R-HSA-9937383 Mitochondrial ribosome-associated quality control 2.497628e-01 0.602
R-HSA-2428928 IRS-related events triggered by IGF1R 2.810166e-01 0.551
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 2.218341e-01 0.654
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 1.652109e-01 0.782
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 2.754339e-01 0.560
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 2.754339e-01 0.560
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 2.754339e-01 0.560
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 2.754339e-01 0.560
R-HSA-5576890 Phase 3 - rapid repolarisation 1.406437e-01 0.852
R-HSA-2470946 Cohesin Loading onto Chromatin 1.406437e-01 0.852
R-HSA-176974 Unwinding of DNA 1.663130e-01 0.779
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 1.788599e-01 0.747
R-HSA-380615 Serotonin clearance from the synaptic cleft 2.153832e-01 0.667
R-HSA-5654733 Negative regulation of FGFR4 signaling 9.937946e-02 1.003
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 9.937946e-02 1.003
R-HSA-399954 Sema3A PAK dependent Axon repulsion 2.502884e-01 0.602
R-HSA-5576886 Phase 4 - resting membrane potential 2.615763e-01 0.582
R-HSA-5654727 Negative regulation of FGFR2 signaling 1.287858e-01 0.890
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 1.389939e-01 0.857
R-HSA-5621480 Dectin-2 family 2.586782e-01 0.587
R-HSA-1433557 Signaling by SCF-KIT 1.813276e-01 0.742
R-HSA-9613829 Chaperone Mediated Autophagy 2.944345e-01 0.531
R-HSA-5654726 Negative regulation of FGFR1 signaling 1.187664e-01 0.925
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 2.726949e-01 0.564
R-HSA-112399 IRS-mediated signalling 2.586782e-01 0.587
R-HSA-9764561 Regulation of CDH1 Function 2.586782e-01 0.587
R-HSA-9759475 Regulation of CDH11 Expression and Function 9.937946e-02 1.003
R-HSA-373755 Semaphorin interactions 2.921706e-01 0.534
R-HSA-5358508 Mismatch Repair 2.944345e-01 0.531
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 1.141873e-01 0.942
R-HSA-9603381 Activated NTRK3 signals through PI3K 1.406437e-01 0.852
R-HSA-937042 IRAK2 mediated activation of TAK1 complex 1.663130e-01 0.779
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 2.388286e-01 0.622
R-HSA-69541 Stabilization of p53 1.546164e-01 0.811
R-HSA-8856828 Clathrin-mediated endocytosis 2.289848e-01 0.640
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 1.187664e-01 0.925
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 2.061757e-01 0.686
R-HSA-388841 Regulation of T cell activation by CD28 family 2.427751e-01 0.615
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.097656e-01 0.960
R-HSA-71737 Pyrophosphate hydrolysis 1.006565e-01 0.997
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 2.153832e-01 0.667
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 2.836468e-01 0.547
R-HSA-2559585 Oncogene Induced Senescence 1.338675e-01 0.873
R-HSA-9610379 HCMV Late Events 2.748643e-01 0.561
R-HSA-170968 Frs2-mediated activation 2.271945e-01 0.644
R-HSA-8853884 Transcriptional Regulation by VENTX 1.652109e-01 0.782
R-HSA-438064 Post NMDA receptor activation events 1.794506e-01 0.746
R-HSA-2644603 Signaling by NOTCH1 in Cancer 2.754339e-01 0.560
R-HSA-9842663 Signaling by LTK 2.153832e-01 0.667
R-HSA-162599 Late Phase of HIV Life Cycle 2.257830e-01 0.646
R-HSA-195721 Signaling by WNT 2.101178e-01 0.678
R-HSA-69563 p53-Dependent G1 DNA Damage Response 2.141733e-01 0.669
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 2.141733e-01 0.669
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 2.457382e-01 0.610
R-HSA-201681 TCF dependent signaling in response to WNT 1.940326e-01 0.712
R-HSA-199992 trans-Golgi Network Vesicle Budding 1.227385e-01 0.911
R-HSA-9839373 Signaling by TGFBR3 1.976655e-01 0.704
R-HSA-9006925 Intracellular signaling by second messengers 1.019753e-01 0.992
R-HSA-8866376 Reelin signalling pathway 1.006565e-01 0.997
R-HSA-199920 CREB phosphorylation 1.275154e-01 0.894
R-HSA-198693 AKT phosphorylates targets in the nucleus 1.663130e-01 0.779
R-HSA-68884 Mitotic Telophase/Cytokinesis 2.033922e-01 0.692
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 2.153832e-01 0.667
R-HSA-446205 Synthesis of GDP-mannose 2.153832e-01 0.667
R-HSA-75892 Platelet Adhesion to exposed collagen 2.271945e-01 0.644
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 2.615763e-01 0.582
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 2.642635e-01 0.578
R-HSA-5633007 Regulation of TP53 Activity 1.355865e-01 0.868
R-HSA-9733709 Cardiogenesis 1.187664e-01 0.925
R-HSA-169893 Prolonged ERK activation events 2.615763e-01 0.582
R-HSA-9758941 Gastrulation 2.484246e-01 0.605
R-HSA-9764302 Regulation of CDH19 Expression and Function 1.141873e-01 0.942
R-HSA-447041 CHL1 interactions 1.406437e-01 0.852
R-HSA-167590 Nef Mediated CD4 Down-regulation 1.406437e-01 0.852
R-HSA-9645460 Alpha-protein kinase 1 signaling pathway 1.912186e-01 0.718
R-HSA-9697154 Disorders of Nervous System Development 2.153832e-01 0.667
R-HSA-9005895 Pervasive developmental disorders 2.153832e-01 0.667
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 2.153832e-01 0.667
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 2.271945e-01 0.644
R-HSA-3270619 IRF3-mediated induction of type I IFN 2.502884e-01 0.602
R-HSA-5578749 Transcriptional regulation by small RNAs 1.227385e-01 0.911
R-HSA-9766229 Degradation of CDH1 2.141733e-01 0.669
R-HSA-68886 M Phase 1.613660e-01 0.792
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 1.097656e-01 0.960
R-HSA-5362517 Signaling by Retinoic Acid 2.754339e-01 0.560
R-HSA-162587 HIV Life Cycle 2.748643e-01 0.561
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 1.537871e-01 0.813
R-HSA-9768759 Regulation of NPAS4 gene expression 2.836468e-01 0.547
R-HSA-69615 G1/S DNA Damage Checkpoints 2.921706e-01 0.534
R-HSA-162906 HIV Infection 1.746348e-01 0.758
R-HSA-5654743 Signaling by FGFR4 1.813276e-01 0.742
R-HSA-1606341 IRF3 mediated activation of type 1 IFN 1.006565e-01 0.997
R-HSA-9675151 Disorders of Developmental Biology 2.726949e-01 0.564
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 2.836468e-01 0.547
R-HSA-109704 PI3K Cascade 2.197053e-01 0.658
R-HSA-1266738 Developmental Biology 1.789608e-01 0.747
R-HSA-5654741 Signaling by FGFR3 1.921982e-01 0.716
R-HSA-9659379 Sensory processing of sound 1.466832e-01 0.834
R-HSA-76002 Platelet activation, signaling and aggregation 1.613995e-01 0.792
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 2.564043e-01 0.591
R-HSA-5654736 Signaling by FGFR1 2.530945e-01 0.597
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 1.406437e-01 0.852
R-HSA-9828642 Respiratory syncytial virus genome transcription 2.388286e-01 0.622
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 2.836468e-01 0.547
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 1.097656e-01 0.960
R-HSA-1474290 Collagen formation 2.100666e-01 0.678
R-HSA-1483249 Inositol phosphate metabolism 1.209792e-01 0.917
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 2.388286e-01 0.622
R-HSA-69236 G1 Phase 1.867516e-01 0.729
R-HSA-69231 Cyclin D associated events in G1 1.867516e-01 0.729
R-HSA-8876725 Protein methylation 2.502884e-01 0.602
R-HSA-1640170 Cell Cycle 1.442602e-01 0.841
R-HSA-168898 Toll-like Receptor Cascades 1.020192e-01 0.991
R-HSA-8986944 Transcriptional Regulation by MECP2 1.946072e-01 0.711
R-HSA-69278 Cell Cycle, Mitotic 1.831415e-01 0.737
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 1.663130e-01 0.779
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 1.338675e-01 0.873
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 2.944345e-01 0.531
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 2.257830e-01 0.646
R-HSA-180024 DARPP-32 events 9.937946e-02 1.003
R-HSA-6804760 Regulation of TP53 Activity through Methylation 2.944345e-01 0.531
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 1.759282e-01 0.755
R-HSA-211000 Gene Silencing by RNA 1.084973e-01 0.965
R-HSA-2262752 Cellular responses to stress 1.629620e-01 0.788
R-HSA-9700206 Signaling by ALK in cancer 2.700232e-01 0.569
R-HSA-8953897 Cellular responses to stimuli 1.706191e-01 0.768
R-HSA-8983711 OAS antiviral response 2.153832e-01 0.667
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 2.726949e-01 0.564
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 2.836468e-01 0.547
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 2.700232e-01 0.569
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 1.227385e-01 0.911
R-HSA-9827857 Specification of primordial germ cells 2.836468e-01 0.547
R-HSA-451927 Interleukin-2 family signaling 1.598972e-01 0.796
R-HSA-5210891 Uptake and function of anthrax toxins 2.836468e-01 0.547
R-HSA-449147 Signaling by Interleukins 1.161083e-01 0.935
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 2.974093e-01 0.527
R-HSA-2428924 IGF1R signaling cascade 2.977397e-01 0.526
R-HSA-74751 Insulin receptor signalling cascade 2.977397e-01 0.526
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 3.033021e-01 0.518
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 3.033021e-01 0.518
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 3.050603e-01 0.516
R-HSA-937041 IKK complex recruitment mediated by RIP1 3.050603e-01 0.516
R-HSA-500753 Pyrimidine biosynthesis 3.050603e-01 0.516
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 3.050603e-01 0.516
R-HSA-392517 Rap1 signalling 3.050603e-01 0.516
R-HSA-1834941 STING mediated induction of host immune responses 3.050603e-01 0.516
R-HSA-373760 L1CAM interactions 3.151205e-01 0.502
R-HSA-9909620 Regulation of PD-L1(CD274) translation 3.155268e-01 0.501
R-HSA-373753 Nephrin family interactions 3.155268e-01 0.501
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 3.155268e-01 0.501
R-HSA-445144 Signal transduction by L1 3.155268e-01 0.501
R-HSA-1592230 Mitochondrial biogenesis 3.192378e-01 0.496
R-HSA-72306 tRNA processing 3.221061e-01 0.492
R-HSA-9705683 SARS-CoV-2-host interactions 3.235960e-01 0.490
R-HSA-5621481 C-type lectin receptors (CLRs) 3.255104e-01 0.487
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 3.258363e-01 0.487
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 3.258363e-01 0.487
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 3.258363e-01 0.487
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 3.359911e-01 0.474
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 3.359911e-01 0.474
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 3.359911e-01 0.474
R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling 3.359911e-01 0.474
R-HSA-8876384 Listeria monocytogenes entry into host cells 3.359911e-01 0.474
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 3.359911e-01 0.474
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 3.359911e-01 0.474
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 3.359911e-01 0.474
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 3.359911e-01 0.474
R-HSA-9034015 Signaling by NTRK3 (TRKC) 3.359911e-01 0.474
R-HSA-9924644 Developmental Lineages of the Mammary Gland 3.419666e-01 0.466
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 3.419666e-01 0.466
R-HSA-9816359 Maternal to zygotic transition (MZT) 3.439404e-01 0.464
R-HSA-112409 RAF-independent MAPK1/3 activation 3.459935e-01 0.461
R-HSA-71384 Ethanol oxidation 3.459935e-01 0.461
R-HSA-166208 mTORC1-mediated signalling 3.459935e-01 0.461
R-HSA-4086398 Ca2+ pathway 3.474400e-01 0.459
R-HSA-162582 Signal Transduction 3.481737e-01 0.458
R-HSA-674695 RNA Polymerase II Pre-transcription Events 3.528984e-01 0.452
R-HSA-8943723 Regulation of PTEN mRNA translation 3.558460e-01 0.449
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 3.558460e-01 0.449
R-HSA-69206 G1/S Transition 3.562703e-01 0.448
R-HSA-1980143 Signaling by NOTCH1 3.637667e-01 0.439
R-HSA-114608 Platelet degranulation 3.644743e-01 0.438
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 3.655505e-01 0.437
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 3.655505e-01 0.437
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 3.655505e-01 0.437
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 3.691753e-01 0.433
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 3.745658e-01 0.426
R-HSA-9620244 Long-term potentiation 3.751095e-01 0.426
R-HSA-400685 Sema4D in semaphorin signaling 3.751095e-01 0.426
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 3.751095e-01 0.426
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 3.845250e-01 0.415
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 3.845250e-01 0.415
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 3.845250e-01 0.415
R-HSA-525793 Myogenesis 3.845250e-01 0.415
R-HSA-3295583 TRP channels 3.845250e-01 0.415
R-HSA-9845614 Sphingolipid catabolism 3.845250e-01 0.415
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 3.852899e-01 0.414
R-HSA-5654738 Signaling by FGFR2 3.852899e-01 0.414
R-HSA-9609646 HCMV Infection 3.891137e-01 0.410
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 3.930367e-01 0.406
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 3.937993e-01 0.405
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 3.937993e-01 0.405
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 3.937993e-01 0.405
R-HSA-73728 RNA Polymerase I Promoter Opening 3.937993e-01 0.405
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 3.937993e-01 0.405
R-HSA-9006115 Signaling by NTRK2 (TRKB) 3.937993e-01 0.405
R-HSA-1483213 Synthesis of PE 3.937993e-01 0.405
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 3.971372e-01 0.401
R-HSA-1500931 Cell-Cell communication 4.002051e-01 0.398
R-HSA-167287 HIV elongation arrest and recovery 4.029343e-01 0.395
R-HSA-167290 Pausing and recovery of HIV elongation 4.029343e-01 0.395
R-HSA-9619483 Activation of AMPK downstream of NMDARs 4.029343e-01 0.395
R-HSA-3858494 Beta-catenin independent WNT signaling 4.092161e-01 0.388
R-HSA-9006335 Signaling by Erythropoietin 4.119323e-01 0.385
R-HSA-9664565 Signaling by ERBB2 KD Mutants 4.119323e-01 0.385
R-HSA-9615710 Late endosomal microautophagy 4.119323e-01 0.385
R-HSA-9674555 Signaling by CSF3 (G-CSF) 4.119323e-01 0.385
R-HSA-210745 Regulation of gene expression in beta cells 4.119323e-01 0.385
R-HSA-69620 Cell Cycle Checkpoints 4.129360e-01 0.384
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 4.132413e-01 0.384
R-HSA-141424 Amplification of signal from the kinetochores 4.169632e-01 0.380
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 4.169632e-01 0.380
R-HSA-5368287 Mitochondrial translation 4.172579e-01 0.380
R-HSA-1227990 Signaling by ERBB2 in Cancer 4.207952e-01 0.376
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 4.207952e-01 0.376
R-HSA-68962 Activation of the pre-replicative complex 4.207952e-01 0.376
R-HSA-1250196 SHC1 events in ERBB2 signaling 4.207952e-01 0.376
R-HSA-8863795 Downregulation of ERBB2 signaling 4.207952e-01 0.376
R-HSA-888590 GABA synthesis, release, reuptake and degradation 4.207952e-01 0.376
R-HSA-112311 Neurotransmitter clearance 4.207952e-01 0.376
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 4.207952e-01 0.376
R-HSA-69190 DNA strand elongation 4.381238e-01 0.358
R-HSA-111465 Apoptotic cleavage of cellular proteins 4.381238e-01 0.358
R-HSA-5083635 Defective B3GALTL causes PpS 4.465935e-01 0.350
R-HSA-9930044 Nuclear RNA decay 4.465935e-01 0.350
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 4.465935e-01 0.350
R-HSA-176187 Activation of ATR in response to replication stress 4.465935e-01 0.350
R-HSA-354192 Integrin signaling 4.465935e-01 0.350
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 4.465935e-01 0.350
R-HSA-1912408 Pre-NOTCH Transcription and Translation 4.477985e-01 0.349
R-HSA-453279 Mitotic G1 phase and G1/S transition 4.529724e-01 0.344
R-HSA-5696394 DNA Damage Recognition in GG-NER 4.549361e-01 0.342
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 4.549361e-01 0.342
R-HSA-3700989 Transcriptional Regulation by TP53 4.561895e-01 0.341
R-HSA-2682334 EPH-Ephrin signaling 4.578737e-01 0.339
R-HSA-74752 Signaling by Insulin receptor 4.578737e-01 0.339
R-HSA-2029481 FCGR activation 4.628716e-01 0.335
R-HSA-5696400 Dual Incision in GG-NER 4.631534e-01 0.334
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 4.631534e-01 0.334
R-HSA-1980145 Signaling by NOTCH2 4.631534e-01 0.334
R-HSA-168638 NOD1/2 Signaling Pathway 4.631534e-01 0.334
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 4.631534e-01 0.334
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 4.631534e-01 0.334
R-HSA-5365859 RA biosynthesis pathway 4.631534e-01 0.334
R-HSA-2142845 Hyaluronan metabolism 4.631534e-01 0.334
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 4.631534e-01 0.334
R-HSA-169911 Regulation of Apoptosis 4.712474e-01 0.327
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 4.712474e-01 0.327
R-HSA-187687 Signalling to ERKs 4.712474e-01 0.327
R-HSA-381042 PERK regulates gene expression 4.712474e-01 0.327
R-HSA-917977 Transferrin endocytosis and recycling 4.712474e-01 0.327
R-HSA-446728 Cell junction organization 4.717341e-01 0.326
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 4.746311e-01 0.324
R-HSA-432720 Lysosome Vesicle Biogenesis 4.792197e-01 0.319
R-HSA-8853659 RET signaling 4.792197e-01 0.319
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 4.825898e-01 0.316
R-HSA-5607764 CLEC7A (Dectin-1) signaling 4.825898e-01 0.316
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 4.839473e-01 0.315
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins 4.870724e-01 0.312
R-HSA-1296072 Voltage gated Potassium channels 4.870724e-01 0.312
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 4.870724e-01 0.312
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 4.870724e-01 0.312
R-HSA-8948216 Collagen chain trimerization 4.870724e-01 0.312
R-HSA-8878159 Transcriptional regulation by RUNX3 4.874496e-01 0.312
R-HSA-168273 Influenza Viral RNA Transcription and Replication 4.877613e-01 0.312
R-HSA-9694516 SARS-CoV-2 Infection 4.878179e-01 0.312
R-HSA-190236 Signaling by FGFR 4.922810e-01 0.308
R-HSA-8875878 MET promotes cell motility 4.948071e-01 0.306
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 4.948071e-01 0.306
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 4.991212e-01 0.302
R-HSA-69618 Mitotic Spindle Checkpoint 5.018574e-01 0.299
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 5.024257e-01 0.299
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 5.024257e-01 0.299
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 5.024257e-01 0.299
R-HSA-201556 Signaling by ALK 5.024257e-01 0.299
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 5.024257e-01 0.299
R-HSA-877300 Interferon gamma signaling 5.028797e-01 0.299
R-HSA-9020702 Interleukin-1 signaling 5.066020e-01 0.295
R-HSA-9006936 Signaling by TGFB family members 5.066238e-01 0.295
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 5.099299e-01 0.292
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 5.099299e-01 0.292
R-HSA-5696395 Formation of Incision Complex in GG-NER 5.099299e-01 0.292
R-HSA-167169 HIV Transcription Elongation 5.099299e-01 0.292
R-HSA-202433 Generation of second messenger molecules 5.099299e-01 0.292
R-HSA-2559580 Oxidative Stress Induced Senescence 5.113172e-01 0.291
R-HSA-8878171 Transcriptional regulation by RUNX1 5.127353e-01 0.290
R-HSA-3214841 PKMTs methylate histone lysines 5.173213e-01 0.286
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 5.173213e-01 0.286
R-HSA-9694548 Maturation of spike protein 5.173213e-01 0.286
R-HSA-5218920 VEGFR2 mediated vascular permeability 5.173213e-01 0.286
R-HSA-9860931 Response of endothelial cells to shear stress 5.206589e-01 0.283
R-HSA-111885 Opioid Signalling 5.206589e-01 0.283
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 5.246017e-01 0.280
R-HSA-442660 SLC-mediated transport of neurotransmitters 5.246017e-01 0.280
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 5.246017e-01 0.280
R-HSA-9833110 RSV-host interactions 5.252850e-01 0.280
R-HSA-379716 Cytosolic tRNA aminoacylation 5.317727e-01 0.274
R-HSA-400508 Incretin synthesis, secretion, and inactivation 5.317727e-01 0.274
R-HSA-165159 MTOR signalling 5.317727e-01 0.274
R-HSA-5619102 SLC transporter disorders 5.324153e-01 0.274
R-HSA-418346 Platelet homeostasis 5.344469e-01 0.272
R-HSA-8953854 Metabolism of RNA 5.365802e-01 0.270
R-HSA-74160 Gene expression (Transcription) 5.409633e-01 0.267
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 5.434875e-01 0.265
R-HSA-2672351 Stimuli-sensing channels 5.434875e-01 0.265
R-HSA-373752 Netrin-1 signaling 5.457932e-01 0.263
R-HSA-3928662 EPHB-mediated forward signaling 5.457932e-01 0.263
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 5.479621e-01 0.261
R-HSA-4608870 Asymmetric localization of PCP proteins 5.526458e-01 0.258
R-HSA-76009 Platelet Aggregation (Plug Formation) 5.526458e-01 0.258
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 5.574374e-01 0.254
R-HSA-9764265 Regulation of CDH1 Expression and Function 5.574374e-01 0.254
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 5.593955e-01 0.252
R-HSA-9861718 Regulation of pyruvate metabolism 5.593955e-01 0.252
R-HSA-9675135 Diseases of DNA repair 5.593955e-01 0.252
R-HSA-75153 Apoptotic execution phase 5.593955e-01 0.252
R-HSA-1912422 Pre-NOTCH Expression and Processing 5.655526e-01 0.248
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 5.660437e-01 0.247
R-HSA-437239 Recycling pathway of L1 5.660437e-01 0.247
R-HSA-9855142 Cellular responses to mechanical stimuli 5.698729e-01 0.244
R-HSA-70263 Gluconeogenesis 5.725921e-01 0.242
R-HSA-425410 Metal ion SLC transporters 5.725921e-01 0.242
R-HSA-168255 Influenza Infection 5.782382e-01 0.238
R-HSA-73893 DNA Damage Bypass 5.790420e-01 0.237
R-HSA-2559583 Cellular Senescence 5.816452e-01 0.235
R-HSA-4420097 VEGFA-VEGFR2 Pathway 5.826475e-01 0.235
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 5.916525e-01 0.228
R-HSA-112315 Transmission across Chemical Synapses 5.955869e-01 0.225
R-HSA-212165 Epigenetic regulation of gene expression 5.955869e-01 0.225
R-HSA-68949 Orc1 removal from chromatin 5.978159e-01 0.223
R-HSA-6794361 Neurexins and neuroligins 5.978159e-01 0.223
R-HSA-9634815 Transcriptional Regulation by NPAS4 5.978159e-01 0.223
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 5.978159e-01 0.223
R-HSA-5339562 Uptake and actions of bacterial toxins 5.978159e-01 0.223
R-HSA-69275 G2/M Transition 6.017201e-01 0.221
R-HSA-212436 Generic Transcription Pathway 6.028970e-01 0.220
R-HSA-1221632 Meiotic synapsis 6.038867e-01 0.219
R-HSA-8956320 Nucleotide biosynthesis 6.038867e-01 0.219
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 6.073553e-01 0.217
R-HSA-453274 Mitotic G2-G2/M phases 6.082701e-01 0.216
R-HSA-72649 Translation initiation complex formation 6.098662e-01 0.215
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 6.098662e-01 0.215
R-HSA-112316 Neuronal System 6.123996e-01 0.213
R-HSA-9012852 Signaling by NOTCH3 6.157558e-01 0.211
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 6.157558e-01 0.211
R-HSA-3214815 HDACs deacetylate histones 6.157558e-01 0.211
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 6.215569e-01 0.207
R-HSA-72702 Ribosomal scanning and start codon recognition 6.215569e-01 0.207
R-HSA-193648 NRAGE signals death through JNK 6.215569e-01 0.207
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 6.215569e-01 0.207
R-HSA-75893 TNF signaling 6.215569e-01 0.207
R-HSA-194138 Signaling by VEGF 6.270880e-01 0.203
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 6.309413e-01 0.200
R-HSA-6782135 Dual incision in TC-NER 6.328986e-01 0.199
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 6.328986e-01 0.199
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 6.337499e-01 0.198
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 6.384419e-01 0.195
R-HSA-379724 tRNA Aminoacylation 6.439018e-01 0.191
R-HSA-983189 Kinesins 6.439018e-01 0.191
R-HSA-1660661 Sphingolipid de novo biosynthesis 6.439018e-01 0.191
R-HSA-389948 Co-inhibition by PD-1 6.460529e-01 0.190
R-HSA-9679506 SARS-CoV Infections 6.471905e-01 0.189
R-HSA-428157 Sphingolipid metabolism 6.490828e-01 0.188
R-HSA-1442490 Collagen degradation 6.492796e-01 0.188
R-HSA-9793380 Formation of paraxial mesoderm 6.492796e-01 0.188
R-HSA-1474165 Reproduction 6.497446e-01 0.187
R-HSA-5576891 Cardiac conduction 6.534131e-01 0.185
R-HSA-375165 NCAM signaling for neurite out-growth 6.545765e-01 0.184
R-HSA-9707616 Heme signaling 6.545765e-01 0.184
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 6.545765e-01 0.184
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 6.550874e-01 0.184
R-HSA-8856688 Golgi-to-ER retrograde transport 6.570510e-01 0.182
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 6.597937e-01 0.181
R-HSA-8848021 Signaling by PTK6 6.597937e-01 0.181
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 6.597937e-01 0.181
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 6.649325e-01 0.177
R-HSA-1234174 Cellular response to hypoxia 6.699939e-01 0.174
R-HSA-9824446 Viral Infection Pathways 6.711635e-01 0.173
R-HSA-9018519 Estrogen-dependent gene expression 6.747854e-01 0.171
R-HSA-163685 Integration of energy metabolism 6.747854e-01 0.171
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 6.749792e-01 0.171
R-HSA-72766 Translation 6.789919e-01 0.168
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 6.840062e-01 0.165
R-HSA-167172 Transcription of the HIV genome 6.847259e-01 0.164
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 6.847259e-01 0.164
R-HSA-381119 Unfolded Protein Response (UPR) 6.850654e-01 0.164
R-HSA-9730414 MITF-M-regulated melanocyte development 6.867969e-01 0.163
R-HSA-9664417 Leishmania phagocytosis 6.884327e-01 0.162
R-HSA-9664422 FCGR3A-mediated phagocytosis 6.884327e-01 0.162
R-HSA-9664407 Parasite infection 6.884327e-01 0.162
R-HSA-73857 RNA Polymerase II Transcription 6.899198e-01 0.161
R-HSA-9006931 Signaling by Nuclear Receptors 6.908622e-01 0.161
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 6.941814e-01 0.159
R-HSA-9840310 Glycosphingolipid catabolism 6.941814e-01 0.159
R-HSA-68882 Mitotic Anaphase 6.950587e-01 0.158
R-HSA-2555396 Mitotic Metaphase and Anaphase 6.977760e-01 0.156
R-HSA-427413 NoRC negatively regulates rRNA expression 6.988028e-01 0.156
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 6.988028e-01 0.156
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 6.988028e-01 0.156
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 6.988028e-01 0.156
R-HSA-453276 Regulation of mitotic cell cycle 6.988028e-01 0.156
R-HSA-418990 Adherens junctions interactions 7.004751e-01 0.155
R-HSA-69052 Switching of origins to a post-replicative state 7.078378e-01 0.150
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 7.078378e-01 0.150
R-HSA-8951664 Neddylation 7.084628e-01 0.150
R-HSA-9013694 Signaling by NOTCH4 7.122536e-01 0.147
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 7.166029e-01 0.145
R-HSA-917937 Iron uptake and transport 7.166029e-01 0.145
R-HSA-5689603 UCH proteinases 7.208867e-01 0.142
R-HSA-73854 RNA Polymerase I Promoter Clearance 7.208867e-01 0.142
R-HSA-9856651 MITF-M-dependent gene expression 7.235521e-01 0.141
R-HSA-9694635 Translation of Structural Proteins 7.251061e-01 0.140
R-HSA-383280 Nuclear Receptor transcription pathway 7.292619e-01 0.137
R-HSA-4086400 PCP/CE pathway 7.292619e-01 0.137
R-HSA-73864 RNA Polymerase I Transcription 7.292619e-01 0.137
R-HSA-416482 G alpha (12/13) signalling events 7.292619e-01 0.137
R-HSA-216083 Integrin cell surface interactions 7.292619e-01 0.137
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 7.295675e-01 0.137
R-HSA-446652 Interleukin-1 family signaling 7.295675e-01 0.137
R-HSA-6798695 Neutrophil degranulation 7.332445e-01 0.135
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 7.333552e-01 0.135
R-HSA-73887 Death Receptor Signaling 7.354719e-01 0.133
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 7.373868e-01 0.132
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 7.373868e-01 0.132
R-HSA-6806834 Signaling by MET 7.373868e-01 0.132
R-HSA-1989781 PPARA activates gene expression 7.383830e-01 0.132
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 7.441234e-01 0.128
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 7.452688e-01 0.128
R-HSA-168249 Innate Immune System 7.471173e-01 0.127
R-HSA-9707564 Cytoprotection by HMOX1 7.491210e-01 0.125
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 7.529151e-01 0.123
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 7.529151e-01 0.123
R-HSA-157118 Signaling by NOTCH 7.552987e-01 0.122
R-HSA-6794362 Protein-protein interactions at synapses 7.566522e-01 0.121
R-HSA-1500620 Meiosis 7.566522e-01 0.121
R-HSA-109581 Apoptosis 7.580056e-01 0.120
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 7.603329e-01 0.119
R-HSA-2467813 Separation of Sister Chromatids 7.633743e-01 0.117
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 7.639582e-01 0.117
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 7.639582e-01 0.117
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 7.639582e-01 0.117
R-HSA-390466 Chaperonin-mediated protein folding 7.675288e-01 0.115
R-HSA-70268 Pyruvate metabolism 7.675288e-01 0.115
R-HSA-5619115 Disorders of transmembrane transporters 7.709627e-01 0.113
R-HSA-9663891 Selective autophagy 7.710457e-01 0.113
R-HSA-112310 Neurotransmitter release cycle 7.779213e-01 0.109
R-HSA-202424 Downstream TCR signaling 7.779213e-01 0.109
R-HSA-421270 Cell-cell junction organization 7.795418e-01 0.108
R-HSA-109582 Hemostasis 7.812573e-01 0.107
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 7.845912e-01 0.105
R-HSA-381070 IRE1alpha activates chaperones 7.845912e-01 0.105
R-HSA-9909648 Regulation of PD-L1(CD274) expression 7.862762e-01 0.104
R-HSA-391251 Protein folding 7.878510e-01 0.104
R-HSA-9772573 Late SARS-CoV-2 Infection Events 7.878510e-01 0.104
R-HSA-5688426 Deubiquitination 7.878560e-01 0.104
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 7.886973e-01 0.103
R-HSA-9664433 Leishmania parasite growth and survival 7.886973e-01 0.103
R-HSA-5689880 Ub-specific processing proteases 7.886973e-01 0.103
R-HSA-168256 Immune System 7.907284e-01 0.102
R-HSA-68867 Assembly of the pre-replicative complex 7.910616e-01 0.102
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 7.910942e-01 0.102
R-HSA-9837999 Mitochondrial protein degradation 7.942238e-01 0.100
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 8.004060e-01 0.097
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 8.034274e-01 0.095
R-HSA-1296071 Potassium Channels 8.034274e-01 0.095
R-HSA-170834 Signaling by TGF-beta Receptor Complex 8.064032e-01 0.093
R-HSA-9614085 FOXO-mediated transcription 8.122209e-01 0.090
R-HSA-193704 p75 NTR receptor-mediated signalling 8.122209e-01 0.090
R-HSA-1483255 PI Metabolism 8.206226e-01 0.086
R-HSA-9842860 Regulation of endogenous retroelements 8.206226e-01 0.086
R-HSA-983712 Ion channel transport 8.242754e-01 0.084
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 8.286499e-01 0.082
R-HSA-5619507 Activation of HOX genes during differentiation 8.286499e-01 0.082
R-HSA-5696398 Nucleotide Excision Repair 8.312453e-01 0.080
R-HSA-68877 Mitotic Prometaphase 8.322898e-01 0.080
R-HSA-9692914 SARS-CoV-1-host interactions 8.338016e-01 0.079
R-HSA-72163 mRNA Splicing - Major Pathway 8.342413e-01 0.079
R-HSA-69239 Synthesis of DNA 8.363193e-01 0.078
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 8.387991e-01 0.076
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 8.387991e-01 0.076
R-HSA-69002 DNA Replication Pre-Initiation 8.412414e-01 0.075
R-HSA-202403 TCR signaling 8.436468e-01 0.074
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 8.455274e-01 0.073
R-HSA-2871796 FCERI mediated MAPK activation 8.483494e-01 0.071
R-HSA-72172 mRNA Splicing 8.543963e-01 0.068
R-HSA-166663 Initial triggering of complement 8.551404e-01 0.068
R-HSA-5357801 Programmed Cell Death 8.561136e-01 0.067
R-HSA-5628897 TP53 Regulates Metabolic Genes 8.573361e-01 0.067
R-HSA-2029485 Role of phospholipids in phagocytosis 8.594987e-01 0.066
R-HSA-2871809 FCERI mediated Ca+2 mobilization 8.594987e-01 0.066
R-HSA-72737 Cap-dependent Translation Initiation 8.616286e-01 0.065
R-HSA-72613 Eukaryotic Translation Initiation 8.616286e-01 0.065
R-HSA-9007101 Rab regulation of trafficking 8.637263e-01 0.064
R-HSA-2980736 Peptide hormone metabolism 8.637263e-01 0.064
R-HSA-397014 Muscle contraction 8.676276e-01 0.062
R-HSA-1660662 Glycosphingolipid metabolism 8.756640e-01 0.058
R-HSA-977606 Regulation of Complement cascade 8.794070e-01 0.056
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 8.812363e-01 0.055
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 8.812363e-01 0.055
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 8.812363e-01 0.055
R-HSA-69481 G2/M Checkpoints 8.848122e-01 0.053
R-HSA-1852241 Organelle biogenesis and maintenance 8.901341e-01 0.051
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 8.932900e-01 0.049
R-HSA-9909396 Circadian clock 8.949094e-01 0.048
R-HSA-1474228 Degradation of the extracellular matrix 8.949094e-01 0.048
R-HSA-8939211 ESR-mediated signaling 9.021893e-01 0.045
R-HSA-202733 Cell surface interactions at the vascular wall 9.021893e-01 0.045
R-HSA-1474244 Extracellular matrix organization 9.022516e-01 0.045
R-HSA-5173105 O-linked glycosylation 9.041248e-01 0.044
R-HSA-9948299 Ribosome-associated quality control 9.055805e-01 0.043
R-HSA-6807070 PTEN Regulation 9.070141e-01 0.042
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 9.098167e-01 0.041
R-HSA-1632852 Macroautophagy 9.098167e-01 0.041
R-HSA-2871837 FCERI mediated NF-kB activation 9.151719e-01 0.038
R-HSA-166658 Complement cascade 9.164605e-01 0.038
R-HSA-69242 S Phase 9.202104e-01 0.036
R-HSA-9679191 Potential therapeutics for SARS 9.226167e-01 0.035
R-HSA-69306 DNA Replication 9.260914e-01 0.033
R-HSA-9734767 Developmental Cell Lineages 9.290943e-01 0.032
R-HSA-9612973 Autophagy 9.294106e-01 0.032
R-HSA-416476 G alpha (q) signalling events 9.299752e-01 0.032
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 9.304837e-01 0.031
R-HSA-2408522 Selenoamino acid metabolism 9.375538e-01 0.028
R-HSA-199991 Membrane Trafficking 9.416963e-01 0.026
R-HSA-9824443 Parasitic Infection Pathways 9.434593e-01 0.025
R-HSA-9658195 Leishmania infection 9.434593e-01 0.025
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 9.480476e-01 0.023
R-HSA-9678108 SARS-CoV-1 Infection 9.480476e-01 0.023
R-HSA-1483257 Phospholipid metabolism 9.526774e-01 0.021
R-HSA-3781865 Diseases of glycosylation 9.547477e-01 0.020
R-HSA-418594 G alpha (i) signalling events 9.584007e-01 0.018
R-HSA-1630316 Glycosaminoglycan metabolism 9.605868e-01 0.017
R-HSA-1280218 Adaptive Immune System 9.648129e-01 0.016
R-HSA-5663205 Infectious disease 9.657519e-01 0.015
R-HSA-1483206 Glycerophospholipid biosynthesis 9.661984e-01 0.015
R-HSA-1643685 Disease 9.788091e-01 0.009
R-HSA-73894 DNA Repair 9.796741e-01 0.009
R-HSA-15869 Metabolism of nucleotides 9.799634e-01 0.009
R-HSA-9824439 Bacterial Infection Pathways 9.865433e-01 0.006
R-HSA-5653656 Vesicle-mediated transport 9.874840e-01 0.005
R-HSA-425407 SLC-mediated transmembrane transport 9.877490e-01 0.005
R-HSA-9711123 Cellular response to chemical stress 9.877644e-01 0.005
R-HSA-211945 Phase I - Functionalization of compounds 9.895142e-01 0.005
R-HSA-597592 Post-translational protein modification 9.927586e-01 0.003
R-HSA-388396 GPCR downstream signalling 9.936299e-01 0.003
R-HSA-392499 Metabolism of proteins 9.938176e-01 0.003
R-HSA-8957322 Metabolism of steroids 9.948509e-01 0.002
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.960431e-01 0.002
R-HSA-372790 Signaling by GPCR 9.975206e-01 0.001
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.979699e-01 0.001
R-HSA-446203 Asparagine N-linked glycosylation 9.988936e-01 0.000
R-HSA-5668914 Diseases of metabolism 9.989765e-01 0.000
R-HSA-211859 Biological oxidations 9.997718e-01 0.000
R-HSA-382551 Transport of small molecules 9.998683e-01 0.000
R-HSA-71291 Metabolism of amino acids and derivatives 9.999488e-01 0.000
R-HSA-556833 Metabolism of lipids 9.999836e-01 0.000
R-HSA-9709957 Sensory Perception 9.999959e-01 0.000
R-HSA-9752946 Expression and translocation of olfactory receptors 9.999968e-01 0.000
R-HSA-381753 Olfactory Signaling Pathway 9.999990e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CDK18CDK18 0.891 0.856 1 0.868
P38GP38G 0.890 0.886 1 0.903
CDK17CDK17 0.888 0.865 1 0.893
HIPK2HIPK2 0.886 0.783 1 0.856
CDK19CDK19 0.885 0.818 1 0.865
KISKIS 0.883 0.760 1 0.810
JNK2JNK2 0.882 0.881 1 0.869
CDK8CDK8 0.881 0.819 1 0.837
P38DP38D 0.880 0.858 1 0.903
CDK16CDK16 0.880 0.827 1 0.881
CDK13CDK13 0.879 0.839 1 0.851
CDK12CDK12 0.879 0.845 1 0.870
CDK7CDK7 0.878 0.818 1 0.834
DYRK2DYRK2 0.877 0.777 1 0.780
ERK1ERK1 0.877 0.830 1 0.846
CDK3CDK3 0.877 0.742 1 0.888
JNK3JNK3 0.875 0.869 1 0.849
CDK9CDK9 0.875 0.834 1 0.845
CDK1CDK1 0.875 0.807 1 0.853
CDK5CDK5 0.875 0.806 1 0.805
DYRK4DYRK4 0.874 0.784 1 0.869
P38BP38B 0.872 0.827 1 0.832
CDK14CDK14 0.870 0.828 1 0.833
CDK10CDK10 0.867 0.779 1 0.847
HIPK1HIPK1 0.867 0.718 1 0.764
DYRK1BDYRK1B 0.867 0.753 1 0.827
P38AP38A 0.865 0.804 1 0.770
ERK2ERK2 0.862 0.819 1 0.806
HIPK4HIPK4 0.861 0.504 1 0.578
CLK3CLK3 0.859 0.497 1 0.549
CDK4CDK4 0.859 0.816 1 0.876
NLKNLK 0.858 0.749 1 0.588
DYRK1ADYRK1A 0.857 0.631 1 0.748
CDK6CDK6 0.857 0.789 1 0.850
HIPK3HIPK3 0.856 0.698 1 0.734
JNK1JNK1 0.856 0.780 1 0.870
DYRK3DYRK3 0.852 0.592 1 0.730
SRPK1SRPK1 0.850 0.363 -3 0.780
CLK1CLK1 0.846 0.446 -3 0.769
CLK4CLK4 0.845 0.424 -3 0.793
ERK5ERK5 0.845 0.409 1 0.487
CLK2CLK2 0.845 0.444 -3 0.768
CDK2CDK2 0.845 0.610 1 0.740
SRPK2SRPK2 0.840 0.293 -3 0.699
MTORMTOR 0.839 0.243 1 0.386
PRP4PRP4 0.838 0.528 -3 0.876
ICKICK 0.836 0.367 -3 0.868
MAKMAK 0.834 0.498 -2 0.751
COTCOT 0.831 -0.050 2 0.851
CDKL5CDKL5 0.829 0.169 -3 0.824
SRPK3SRPK3 0.829 0.255 -3 0.751
CDKL1CDKL1 0.826 0.142 -3 0.831
CDC7CDC7 0.824 -0.089 1 0.227
MOKMOK 0.823 0.461 1 0.646
TBK1TBK1 0.823 -0.124 1 0.187
ERK7ERK7 0.823 0.313 2 0.592
NDR2NDR2 0.822 0.011 -3 0.860
MOSMOS 0.821 -0.018 1 0.265
PRPKPRPK 0.821 -0.079 -1 0.864
IKKEIKKE 0.820 -0.129 1 0.190
GCN2GCN2 0.820 -0.138 2 0.781
PIM3PIM3 0.820 -0.009 -3 0.856
PKN3PKN3 0.820 -0.004 -3 0.861
ULK2ULK2 0.819 -0.121 2 0.764
SKMLCKSKMLCK 0.819 0.023 -2 0.915
NEK6NEK6 0.819 -0.027 -2 0.874
PRKD1PRKD1 0.819 0.019 -3 0.861
CAMK1BCAMK1B 0.818 -0.009 -3 0.889
RSK2RSK2 0.818 0.033 -3 0.793
ATRATR 0.818 -0.042 1 0.258
WNK1WNK1 0.818 -0.031 -2 0.905
MST4MST4 0.818 -0.011 2 0.828
PDHK4PDHK4 0.817 -0.135 1 0.277
RAF1RAF1 0.817 -0.171 1 0.211
AURCAURC 0.816 0.085 -2 0.754
DSTYKDSTYK 0.816 -0.108 2 0.857
P90RSKP90RSK 0.816 0.027 -3 0.805
BMPR2BMPR2 0.815 -0.131 -2 0.886
PKCDPKCD 0.815 0.022 2 0.769
NDR1NDR1 0.815 -0.019 -3 0.858
RSK3RSK3 0.815 0.020 -3 0.791
CAMLCKCAMLCK 0.814 0.036 -2 0.898
NIKNIK 0.814 -0.024 -3 0.909
PDHK1PDHK1 0.814 -0.133 1 0.256
TGFBR2TGFBR2 0.813 -0.064 -2 0.809
PKN2PKN2 0.813 -0.022 -3 0.868
CHAK2CHAK2 0.813 -0.035 -1 0.873
IKKBIKKB 0.813 -0.160 -2 0.752
PRKD2PRKD2 0.812 0.020 -3 0.794
NUAK2NUAK2 0.812 0.007 -3 0.859
RIPK3RIPK3 0.812 -0.097 3 0.841
NEK7NEK7 0.812 -0.134 -3 0.881
DAPK2DAPK2 0.812 0.008 -3 0.896
IRE1IRE1 0.812 -0.038 1 0.201
PIM1PIM1 0.811 0.033 -3 0.802
PKACGPKACG 0.811 0.017 -2 0.802
NEK9NEK9 0.810 -0.097 2 0.828
P70S6KBP70S6KB 0.810 0.015 -3 0.819
PKCAPKCA 0.810 0.040 2 0.720
PKCBPKCB 0.809 0.019 2 0.733
MNK2MNK2 0.809 0.028 -2 0.865
HUNKHUNK 0.808 -0.113 2 0.788
ULK1ULK1 0.808 -0.136 -3 0.870
MLK1MLK1 0.808 -0.128 2 0.799
CAMK2GCAMK2G 0.807 -0.111 2 0.766
PKCZPKCZ 0.807 0.018 2 0.777
LATS2LATS2 0.807 -0.028 -5 0.759
MLK2MLK2 0.807 -0.069 2 0.798
PAK6PAK6 0.807 0.061 -2 0.778
PAK1PAK1 0.806 0.013 -2 0.840
AMPKA1AMPKA1 0.806 -0.057 -3 0.877
MARK4MARK4 0.806 -0.061 4 0.826
GRK5GRK5 0.806 -0.140 -3 0.885
PAK3PAK3 0.805 -0.008 -2 0.836
WNK3WNK3 0.805 -0.164 1 0.210
NIM1NIM1 0.805 -0.050 3 0.839
PKCGPKCG 0.805 0.001 2 0.727
SGK3SGK3 0.805 0.041 -3 0.788
BCKDKBCKDK 0.805 -0.127 -1 0.816
IRE2IRE2 0.804 -0.044 2 0.744
CAMK2DCAMK2D 0.804 -0.082 -3 0.870
MNK1MNK1 0.804 0.028 -2 0.868
MAPKAPK3MAPKAPK3 0.804 -0.054 -3 0.801
PKACBPKACB 0.804 0.065 -2 0.764
IKKAIKKA 0.804 -0.086 -2 0.734
PHKG1PHKG1 0.804 -0.034 -3 0.850
DNAPKDNAPK 0.804 -0.025 1 0.236
PKRPKR 0.803 -0.028 1 0.225
VRK2VRK2 0.803 0.114 1 0.315
MASTLMASTL 0.803 -0.140 -2 0.817
PKG2PKG2 0.803 0.043 -2 0.756
AKT2AKT2 0.803 0.058 -3 0.708
MLK3MLK3 0.802 -0.048 2 0.728
GRK1GRK1 0.802 -0.035 -2 0.772
AMPKA2AMPKA2 0.802 -0.039 -3 0.842
AURBAURB 0.802 0.044 -2 0.749
NEK2NEK2 0.802 -0.065 2 0.811
RIPK1RIPK1 0.802 -0.152 1 0.200
LATS1LATS1 0.801 0.020 -3 0.871
BMPR1BBMPR1B 0.801 -0.047 1 0.195
PINK1PINK1 0.801 0.167 1 0.409
MSK2MSK2 0.801 -0.008 -3 0.771
TSSK1TSSK1 0.800 -0.045 -3 0.892
ANKRD3ANKRD3 0.800 -0.151 1 0.228
PKCHPKCH 0.800 -0.018 2 0.715
ALK4ALK4 0.800 -0.061 -2 0.828
PRKD3PRKD3 0.800 -0.006 -3 0.771
RSK4RSK4 0.800 0.025 -3 0.759
TTBK2TTBK2 0.800 -0.155 2 0.695
TGFBR1TGFBR1 0.799 -0.051 -2 0.801
MAPKAPK2MAPKAPK2 0.798 -0.037 -3 0.750
MELKMELK 0.798 -0.056 -3 0.830
MPSK1MPSK1 0.798 0.052 1 0.260
GSK3AGSK3A 0.798 0.196 4 0.441
ATMATM 0.797 -0.087 1 0.224
DLKDLK 0.797 -0.213 1 0.230
YSK4YSK4 0.797 -0.128 1 0.198
TLK2TLK2 0.796 -0.094 1 0.199
MSK1MSK1 0.796 0.015 -3 0.773
TSSK2TSSK2 0.796 -0.100 -5 0.765
PAK2PAK2 0.796 -0.025 -2 0.824
CHAK1CHAK1 0.795 -0.113 2 0.760
NUAK1NUAK1 0.795 -0.044 -3 0.808
GRK6GRK6 0.795 -0.158 1 0.212
CAMK4CAMK4 0.795 -0.102 -3 0.841
GRK7GRK7 0.795 -0.021 1 0.232
AURAAURA 0.795 0.032 -2 0.728
PLK1PLK1 0.794 -0.125 -2 0.821
PKCTPKCT 0.794 -0.002 2 0.721
SMG1SMG1 0.794 -0.080 1 0.240
PIM2PIM2 0.794 0.027 -3 0.768
MEKK1MEKK1 0.794 -0.072 1 0.225
QSKQSK 0.793 -0.042 4 0.803
PRKXPRKX 0.793 0.062 -3 0.690
MLK4MLK4 0.793 -0.094 2 0.709
MST3MST3 0.793 -0.014 2 0.827
GRK4GRK4 0.792 -0.172 -2 0.824
AKT1AKT1 0.792 0.041 -3 0.726
IRAK4IRAK4 0.792 -0.073 1 0.187
PLK4PLK4 0.792 -0.095 2 0.599
DCAMKL1DCAMKL1 0.792 -0.027 -3 0.807
WNK4WNK4 0.791 -0.076 -2 0.885
QIKQIK 0.791 -0.107 -3 0.860
MYLK4MYLK4 0.790 -0.013 -2 0.846
PERKPERK 0.790 -0.106 -2 0.838
CAMK2ACAMK2A 0.790 -0.041 2 0.748
CAMK2BCAMK2B 0.790 -0.077 2 0.725
MEK1MEK1 0.790 -0.163 2 0.798
PAK5PAK5 0.790 0.026 -2 0.713
PKCIPKCI 0.790 0.015 2 0.746
NEK5NEK5 0.790 -0.078 1 0.201
ZAKZAK 0.789 -0.125 1 0.217
DRAK1DRAK1 0.789 -0.120 1 0.182
TAO3TAO3 0.789 -0.026 1 0.242
PAK4PAK4 0.788 0.039 -2 0.728
ACVR2AACVR2A 0.788 -0.108 -2 0.798
SIKSIK 0.788 -0.060 -3 0.784
ACVR2BACVR2B 0.788 -0.109 -2 0.805
PKACAPKACA 0.788 0.044 -2 0.722
PHKG2PHKG2 0.787 -0.057 -3 0.822
HRIHRI 0.787 -0.138 -2 0.857
MEKK2MEKK2 0.787 -0.091 2 0.783
ALK2ALK2 0.787 -0.092 -2 0.805
MAPKAPK5MAPKAPK5 0.786 -0.089 -3 0.751
MEK5MEK5 0.786 -0.139 2 0.793
FAM20CFAM20C 0.786 -0.052 2 0.536
PKCEPKCE 0.786 0.029 2 0.717
BRSK2BRSK2 0.786 -0.096 -3 0.841
CAMK1GCAMK1G 0.785 -0.056 -3 0.785
SMMLCKSMMLCK 0.784 -0.009 -3 0.846
MARK3MARK3 0.784 -0.064 4 0.754
P70S6KP70S6K 0.784 -0.019 -3 0.732
LKB1LKB1 0.784 -0.007 -3 0.889
PDK1PDK1 0.783 -0.037 1 0.246
BRSK1BRSK1 0.783 -0.081 -3 0.816
GSK3BGSK3B 0.783 0.047 4 0.434
BRAFBRAF 0.783 -0.137 -4 0.842
MARK2MARK2 0.782 -0.076 4 0.724
SNRKSNRK 0.782 -0.145 2 0.656
PLK3PLK3 0.782 -0.142 2 0.724
BMPR1ABMPR1A 0.781 -0.077 1 0.189
MEKK3MEKK3 0.781 -0.177 1 0.217
TAO2TAO2 0.781 -0.037 2 0.828
DCAMKL2DCAMKL2 0.781 -0.060 -3 0.828
AKT3AKT3 0.781 0.045 -3 0.646
PKN1PKN1 0.781 -0.011 -3 0.750
MEKK6MEKK6 0.781 -0.049 1 0.219
GRK2GRK2 0.780 -0.102 -2 0.713
MAP3K15MAP3K15 0.780 -0.063 1 0.224
SGK1SGK1 0.780 0.057 -3 0.627
GAKGAK 0.780 -0.033 1 0.254
TLK1TLK1 0.780 -0.151 -2 0.836
NEK11NEK11 0.780 -0.114 1 0.234
CHK1CHK1 0.779 -0.105 -3 0.836
NEK4NEK4 0.779 -0.102 1 0.188
DAPK3DAPK3 0.778 0.001 -3 0.821
NEK8NEK8 0.778 -0.131 2 0.808
SSTKSSTK 0.778 -0.062 4 0.804
HGKHGK 0.777 -0.046 3 0.910
TNIKTNIK 0.777 -0.019 3 0.906
PASKPASK 0.777 -0.059 -3 0.872
GCKGCK 0.777 -0.061 1 0.212
KHS1KHS1 0.776 -0.009 1 0.206
ROCK2ROCK2 0.776 0.035 -3 0.812
CK1ECK1E 0.776 -0.035 -3 0.560
LOKLOK 0.776 -0.037 -2 0.789
MRCKBMRCKB 0.775 0.030 -3 0.761
MINKMINK 0.775 -0.084 1 0.192
PBKPBK 0.774 -0.017 1 0.227
VRK1VRK1 0.774 -0.081 2 0.826
NEK1NEK1 0.774 -0.090 1 0.186
HPK1HPK1 0.774 -0.055 1 0.212
TTBK1TTBK1 0.773 -0.163 2 0.611
MARK1MARK1 0.773 -0.113 4 0.774
CK1G1CK1G1 0.773 -0.057 -3 0.558
LRRK2LRRK2 0.773 -0.013 2 0.833
KHS2KHS2 0.772 0.000 1 0.217
BUB1BUB1 0.772 0.008 -5 0.720
CAMKK1CAMKK1 0.772 -0.170 -2 0.762
CAMKK2CAMKK2 0.771 -0.125 -2 0.766
DAPK1DAPK1 0.771 -0.007 -3 0.805
CAMK1DCAMK1D 0.771 -0.044 -3 0.700
YSK1YSK1 0.770 -0.059 2 0.803
IRAK1IRAK1 0.770 -0.198 -1 0.787
NEK3NEK3 0.770 -0.047 1 0.220
MRCKAMRCKA 0.770 0.003 -3 0.775
HASPINHASPIN 0.769 0.017 -1 0.717
EEF2KEEF2K 0.769 -0.076 3 0.860
MST2MST2 0.769 -0.137 1 0.202
SBKSBK 0.769 0.098 -3 0.583
CK1DCK1D 0.769 -0.016 -3 0.511
DMPK1DMPK1 0.768 0.056 -3 0.777
CHK2CHK2 0.766 -0.028 -3 0.656
SLKSLK 0.765 -0.069 -2 0.722
PKG1PKG1 0.765 0.009 -2 0.681
STK33STK33 0.764 -0.117 2 0.581
ROCK1ROCK1 0.764 0.022 -3 0.778
CK1A2CK1A2 0.764 -0.038 -3 0.508
CAMK1ACAMK1A 0.763 -0.026 -3 0.677
GRK3GRK3 0.763 -0.106 -2 0.667
MST1MST1 0.762 -0.149 1 0.192
TAK1TAK1 0.762 -0.186 1 0.197
BIKEBIKE 0.762 -0.023 1 0.234
CK2A2CK2A2 0.761 -0.084 1 0.172
CRIKCRIK 0.760 0.025 -3 0.723
RIPK2RIPK2 0.760 -0.196 1 0.194
MEK2MEK2 0.760 -0.179 2 0.778
MYO3BMYO3B 0.759 -0.021 2 0.814
AAK1AAK1 0.758 0.014 1 0.228
TTKTTK 0.758 -0.055 -2 0.839
TAO1TAO1 0.757 -0.057 1 0.212
OSR1OSR1 0.757 -0.067 2 0.773
ASK1ASK1 0.756 -0.098 1 0.226
CK2A1CK2A1 0.753 -0.091 1 0.165
PDHK3_TYRPDHK3_TYR 0.753 0.138 4 0.890
PLK2PLK2 0.751 -0.111 -3 0.798
MYO3AMYO3A 0.751 -0.074 1 0.210
LIMK2_TYRLIMK2_TYR 0.751 0.164 -3 0.925
PKMYT1_TYRPKMYT1_TYR 0.749 0.155 3 0.924
TESK1_TYRTESK1_TYR 0.746 0.044 3 0.933
PDHK4_TYRPDHK4_TYR 0.742 0.025 2 0.832
MAP2K4_TYRMAP2K4_TYR 0.742 0.003 -1 0.872
MAP2K7_TYRMAP2K7_TYR 0.740 -0.068 2 0.820
MAP2K6_TYRMAP2K6_TYR 0.739 -0.002 -1 0.876
RETRET 0.739 -0.075 1 0.237
YANK3YANK3 0.739 -0.064 2 0.373
LIMK1_TYRLIMK1_TYR 0.738 0.026 2 0.824
PINK1_TYRPINK1_TYR 0.737 -0.120 1 0.267
MST1RMST1R 0.737 -0.054 3 0.899
TNNI3K_TYRTNNI3K_TYR 0.736 0.030 1 0.251
STLK3STLK3 0.736 -0.174 1 0.196
ALPHAK3ALPHAK3 0.736 -0.133 -1 0.757
JAK2JAK2 0.735 -0.080 1 0.248
CSF1RCSF1R 0.735 -0.053 3 0.877
PDHK1_TYRPDHK1_TYR 0.735 -0.081 -1 0.880
TYK2TYK2 0.735 -0.139 1 0.223
BMPR2_TYRBMPR2_TYR 0.734 -0.031 -1 0.831
ROS1ROS1 0.734 -0.072 3 0.864
NEK10_TYRNEK10_TYR 0.733 -0.070 1 0.214
TYRO3TYRO3 0.731 -0.114 3 0.882
TNK1TNK1 0.731 -0.015 3 0.872
JAK1JAK1 0.731 -0.048 1 0.217
ABL2ABL2 0.730 -0.076 -1 0.808
DDR1DDR1 0.729 -0.099 4 0.821
FGRFGR 0.728 -0.112 1 0.191
YES1YES1 0.728 -0.077 -1 0.855
EPHA6EPHA6 0.728 -0.099 -1 0.817
FGFR1FGFR1 0.728 -0.013 3 0.847
ABL1ABL1 0.727 -0.076 -1 0.809
JAK3JAK3 0.727 -0.110 1 0.237
CK1ACK1A 0.727 -0.059 -3 0.416
FGFR2FGFR2 0.727 -0.032 3 0.865
EPHB4EPHB4 0.726 -0.120 -1 0.802
TNK2TNK2 0.725 -0.079 3 0.832
KDRKDR 0.725 -0.055 3 0.841
TXKTXK 0.725 -0.078 1 0.193
PDGFRBPDGFRB 0.724 -0.149 3 0.885
KITKIT 0.722 -0.111 3 0.875
FLT3FLT3 0.722 -0.140 3 0.879
LCKLCK 0.721 -0.083 -1 0.806
BLKBLK 0.721 -0.064 -1 0.812
TEKTEK 0.721 -0.013 3 0.822
ITKITK 0.720 -0.124 -1 0.785
FERFER 0.720 -0.178 1 0.208
HCKHCK 0.720 -0.130 -1 0.806
INSRRINSRR 0.719 -0.140 3 0.831
DDR2DDR2 0.719 -0.007 3 0.807
AXLAXL 0.718 -0.129 3 0.862
PDGFRAPDGFRA 0.718 -0.167 3 0.884
METMET 0.716 -0.111 3 0.870
SRMSSRMS 0.716 -0.175 1 0.188
MERTKMERTK 0.715 -0.132 3 0.864
EPHB1EPHB1 0.714 -0.187 1 0.196
FGFR3FGFR3 0.714 -0.067 3 0.838
WEE1_TYRWEE1_TYR 0.714 -0.080 -1 0.743
EPHB3EPHB3 0.713 -0.162 -1 0.788
EPHA4EPHA4 0.713 -0.130 2 0.719
EPHB2EPHB2 0.711 -0.166 -1 0.776
ALKALK 0.711 -0.146 3 0.804
TECTEC 0.711 -0.137 -1 0.725
FLT1FLT1 0.710 -0.136 -1 0.799
FYNFYN 0.710 -0.093 -1 0.777
BMXBMX 0.710 -0.124 -1 0.673
FLT4FLT4 0.710 -0.137 3 0.841
ERBB2ERBB2 0.709 -0.160 1 0.210
EPHA1EPHA1 0.708 -0.138 3 0.857
FRKFRK 0.708 -0.142 -1 0.808
NTRK1NTRK1 0.708 -0.201 -1 0.804
PTK2BPTK2B 0.707 -0.098 -1 0.786
LTKLTK 0.707 -0.160 3 0.828
PTK6PTK6 0.707 -0.185 -1 0.750
CK1G3CK1G3 0.707 -0.064 -3 0.368
INSRINSR 0.707 -0.150 3 0.821
NTRK2NTRK2 0.707 -0.193 3 0.847
NTRK3NTRK3 0.706 -0.140 -1 0.754
BTKBTK 0.706 -0.216 -1 0.758
EPHA7EPHA7 0.705 -0.145 2 0.724
EGFREGFR 0.705 -0.114 1 0.188
SRCSRC 0.704 -0.107 -1 0.795
YANK2YANK2 0.704 -0.090 2 0.382
MATKMATK 0.704 -0.104 -1 0.741
LYNLYN 0.703 -0.142 3 0.819
MUSKMUSK 0.702 -0.122 1 0.165
FGFR4FGFR4 0.700 -0.110 -1 0.750
EPHA3EPHA3 0.700 -0.174 2 0.695
CSKCSK 0.698 -0.158 2 0.735
EPHA8EPHA8 0.698 -0.138 -1 0.762
EPHA5EPHA5 0.694 -0.170 2 0.698
ERBB4ERBB4 0.692 -0.106 1 0.184
PTK2PTK2 0.690 -0.101 -1 0.714
SYKSYK 0.688 -0.121 -1 0.706
IGF1RIGF1R 0.688 -0.157 3 0.765
EPHA2EPHA2 0.686 -0.157 -1 0.705
CK1G2CK1G2 0.682 -0.076 -3 0.469
ZAP70ZAP70 0.679 -0.077 -1 0.634
FESFES 0.676 -0.154 -1 0.673