Motif 689 (n=115)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087X0R7 | SENP3-EIF4A1 | S285 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
| O14715 | RGPD8 | S1223 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15061 | SYNM | S699 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15061 | SYNM | S1304 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15068 | MCF2L | S1041 | ochoa | Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein) | Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). {ECO:0000250|UniProtKB:Q63406, ECO:0000269|PubMed:15157669}.; FUNCTION: [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669). {ECO:0000269|PubMed:15157669}. |
| O43684 | BUB3 | S211 | ochoa|psp | Mitotic checkpoint protein BUB3 | Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:18199686}. |
| O75582 | RPS6KA5 | S628 | ochoa | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| O75923 | DYSF | S1540 | ochoa | Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1) | Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). {ECO:0000250}. |
| O96019 | ACTL6A | S51 | ochoa | Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250|UniProtKB:Q9Z2N8, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:15196461, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P06241 | FYN | S21 | ochoa|psp | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P09874 | PARP1 | S519 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0DJD0 | RGPD1 | S1208 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1216 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DMM9 | SULT1A3 | S251 | ochoa | Sulfotransferase 1A3 (ST1A3) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Catecholamine-sulfating phenol sulfotransferase) (HAST3) (M-PST) (Monoamine-sulfating phenol sulfotransferase) (Placental estrogen sulfotransferase) (Sulfotransferase 1A3/1A4) (Sulfotransferase, monoamine-preferring) (Thermolabile phenol sulfotransferase) (TL-PST) | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, (R)-adrenaline/epinephrine, (R)-noradrenaline/norepinephrine and serotonin) and phenolic and catechol drugs (PubMed:8093002, PubMed:29524394, PubMed:14622112, PubMed:15358107). Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (PubMed:10199779). {ECO:0000269|PubMed:10199779, ECO:0000269|PubMed:14622112, ECO:0000269|PubMed:15358107, ECO:0000269|PubMed:29524394, ECO:0000269|PubMed:8093002}. |
| P0DMN0 | SULT1A4 | S251 | ochoa | Sulfotransferase 1A4 (ST1A4) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Sulfotransferase 1A3/1A4) | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, (R)-adrenaline/epinephrine, (R)-noradrenaline/norepinephrine and serotonin) and phenolic and catechol drugs (PubMed:15358107, PubMed:29524394). Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (PubMed:10199779). {ECO:0000269|PubMed:10199779, ECO:0000269|PubMed:15358107, ECO:0000269|PubMed:29524394}. |
| P0DPH7 | TUBA3C | T82 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | T82 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P13010 | XRCC5 | S694 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P14625 | HSP90B1 | S674 | psp | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P15311 | EZR | S249 | ochoa | Ezrin (Cytovillin) (Villin-2) (p81) | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
| P19022 | CDH2 | S135 | ochoa | Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) | Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. {ECO:0000250|UniProtKB:P10288, ECO:0000250|UniProtKB:P15116, ECO:0000269|PubMed:31585109}. |
| P20810 | CAST | S440 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P26038 | MSN | S249 | ochoa | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
| P35241 | RDX | S249 | ochoa | Radixin | Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. |
| P35637 | FUS | S439 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P46821 | MAP1B | S1939 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49792 | RANBP2 | S2199 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P68363 | TUBA1B | T82 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P78527 | PRKDC | S511 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P98164 | LRP2 | S4527 | psp | Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) | Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity). {ECO:0000250|UniProtKB:A2ARV4, ECO:0000250|UniProtKB:C0HL13, ECO:0000250|UniProtKB:P98158, ECO:0000269|PubMed:15126248, ECO:0000269|PubMed:23825075}. |
| Q01105 | SET | S165 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q02790 | FKBP4 | S26 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q02818 | NUCB1 | S320 | ochoa | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q02952 | AKAP12 | S1691 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q09666 | AHNAK | S470 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T590 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S613 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T718 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S793 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1042 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1170 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1298 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1344 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T1472 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1802 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2138 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2423 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2600 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2984 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3112 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3240 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4360 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4614 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4803 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4870 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T4877 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5279 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5318 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5393 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5519 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5573 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5620 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5807 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q0ZGT2 | NEXN | S168 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12767 | TMEM94 | S445 | ochoa | Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase) | Could function in the uptake of Mg(2+) from the cytosol into the endoplasmic reticulum and regulate intracellular Mg(2+) homeostasis. {ECO:0000269|PubMed:38513662}. |
| Q12874 | SF3A3 | S299 | ochoa | Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:8022796}. |
| Q12888 | TP53BP1 | S771 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13017 | ARHGAP5 | S1088 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13435 | SF3B2 | S861 | ochoa | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| Q14247 | CTTN | S98 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | S135 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q15652 | JMJD1C | S1628 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q58DX5 | NAALADL2 | S280 | ochoa | Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2) | May be catalytically inactive. |
| Q5VU43 | PDE4DIP | S1096 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q69YH5 | CDCA2 | S407 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6NZI2 | CAVIN1 | S127 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6PEY2 | TUBA3E | T82 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6WCQ1 | MPRIP | S269 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZSZ6 | TSHZ1 | S544 | ochoa | Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q709C8 | VPS13C | S1398 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
| Q71U36 | TUBA1A | T82 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z3J3 | RGPD4 | S1224 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q8IVF2 | AHNAK2 | S820 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S1198 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4425 | ochoa | Protein AHNAK2 | None |
| Q8IZD2 | KMT2E | S269 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8NC06 | ACBD4 | S183 | psp | Acyl-CoA-binding domain-containing protein 4 | Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters. |
| Q8NDI1 | EHBP1 | S369 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NI08 | NCOA7 | S609 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8WWQ0 | PHIP | S1524 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q92823 | NRCAM | S1254 | ochoa | Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) | Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}. |
| Q96RK0 | CIC | S1389 | psp | Protein capicua homolog | Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. {ECO:0000250|UniProtKB:Q924A2}. |
| Q96RR4 | CAMKK2 | S86 | ochoa | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Q96S82 | UBL7 | S123 | ochoa | Ubiquitin-like protein 7 (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP) (Ubiquitin-like protein SB132) | Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway. {ECO:0000269|PubMed:19690332}. |
| Q99666 | RGPD5 | S1223 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BQE3 | TUBA1C | T82 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9GZR1 | SENP6 | S606 | ochoa | Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. |
| Q9H2J7 | SLC6A15 | S675 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9H4L4 | SENP3 | S355 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H582 | ZNF644 | S819 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9NQE9 | HINT3 | S28 | ochoa | Adenosine 5'-monophosphoramidase HINT3 (EC 3.9.1.-) (Histidine triad nucleotide-binding protein 3) (HINT-3) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:17870088). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (PubMed:17870088). Hydrolyzes 3-indolepropionic acyl-adenylate and fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17870088). {ECO:0000269|PubMed:17870088}. |
| Q9NR50 | EIF2B3 | S428 | ochoa | Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
| Q9NS23 | RASSF1 | S135 | psp | Ras association domain-containing protein 1 | Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291, ECO:0000269|PubMed:12024041, ECO:0000269|PubMed:14743218, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:15949439, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:21199877}. |
| Q9NVU0 | POLR3E | S162 | ochoa | DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3D/RPC4 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:P36121, ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:35637192}. |
| Q9NZ72 | STMN3 | S50 | ochoa | Stathmin-3 (SCG10-like protein) | Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. {ECO:0000250}. |
| Q9UKL3 | CASP8AP2 | S815 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9ULD2 | MTUS1 | S279 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9UPU5 | USP24 | S117 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPU5 | USP24 | S1854 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UQE7 | SMC3 | S886 | ochoa | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
| Q9Y2H2 | INPP5F | S830 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| P30048 | PRDX3 | S86 | Sugiyama | Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:17707404, PubMed:29438714, PubMed:33889951, PubMed:7733872). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). Required for the maintenance of physical strength (By similarity). {ECO:0000250|UniProtKB:P20108, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:17707404, ECO:0000269|PubMed:29438714, ECO:0000269|PubMed:33889951, ECO:0000269|PubMed:7733872}. |
| P13667 | PDIA4 | S135 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| Q969U7 | PSMG2 | S166 | Sugiyama | Proteasome assembly chaperone 2 (PAC-2) (Hepatocellular carcinoma-susceptibility protein 3) (Tumor necrosis factor superfamily member 5-induced protein 1) | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}. |
| P40429 | RPL13A | S44 | Sugiyama | Large ribosomal subunit protein uL13 (23 kDa highly basic protein) (60S ribosomal protein L13a) | Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:14567916, PubMed:17218275, PubMed:23636399, PubMed:32669547). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (PubMed:23071094). Involved in methylation of rRNA (PubMed:17921318). {ECO:0000269|PubMed:14567916, ECO:0000269|PubMed:17218275, ECO:0000269|PubMed:17921318, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-437239 | Recycling pathway of L1 | 1.504796e-12 | 11.823 |
| R-HSA-373760 | L1CAM interactions | 3.542924e-10 | 9.451 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.630608e-09 | 8.788 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 4.776421e-09 | 8.321 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 6.207279e-09 | 8.207 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.014168e-08 | 7.994 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.958275e-08 | 7.529 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.007634e-07 | 6.997 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.145513e-07 | 6.941 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.369048e-07 | 6.864 |
| R-HSA-190861 | Gap junction assembly | 1.830935e-07 | 6.737 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.728791e-07 | 6.428 |
| R-HSA-9646399 | Aggrephagy | 4.039947e-07 | 6.394 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.139317e-07 | 6.289 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.370974e-07 | 6.196 |
| R-HSA-190828 | Gap junction trafficking | 7.238695e-07 | 6.140 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 9.993751e-07 | 6.000 |
| R-HSA-422475 | Axon guidance | 1.032701e-06 | 5.986 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.226714e-06 | 5.911 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.347703e-06 | 5.870 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.740974e-06 | 5.759 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.174533e-06 | 5.663 |
| R-HSA-9675108 | Nervous system development | 2.243713e-06 | 5.649 |
| R-HSA-983189 | Kinesins | 3.359200e-06 | 5.474 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.960183e-06 | 5.402 |
| R-HSA-68877 | Mitotic Prometaphase | 4.613499e-06 | 5.336 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.030696e-06 | 5.298 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 7.845950e-06 | 5.105 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 9.031087e-06 | 5.044 |
| R-HSA-68882 | Mitotic Anaphase | 1.080595e-05 | 4.966 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.117185e-05 | 4.952 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.437287e-05 | 4.842 |
| R-HSA-9833482 | PKR-mediated signaling | 1.437287e-05 | 4.842 |
| R-HSA-5620924 | Intraflagellar transport | 2.158479e-05 | 4.666 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.472016e-05 | 4.607 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.333850e-05 | 4.632 |
| R-HSA-9663891 | Selective autophagy | 2.472016e-05 | 4.607 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.818333e-05 | 4.550 |
| R-HSA-391251 | Protein folding | 3.265125e-05 | 4.486 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.250912e-05 | 4.372 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.250912e-05 | 4.372 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.212584e-05 | 4.142 |
| R-HSA-2262752 | Cellular responses to stress | 1.012561e-04 | 3.995 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.280938e-04 | 3.892 |
| R-HSA-68886 | M Phase | 1.282710e-04 | 3.892 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.510299e-04 | 3.821 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.628723e-04 | 3.788 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.459691e-04 | 3.609 |
| R-HSA-9609690 | HCMV Early Events | 2.809672e-04 | 3.551 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.137144e-04 | 3.503 |
| R-HSA-1632852 | Macroautophagy | 3.475933e-04 | 3.459 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.364285e-04 | 3.360 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.419042e-04 | 3.355 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.135593e-04 | 3.289 |
| R-HSA-9612973 | Autophagy | 5.756526e-04 | 3.240 |
| R-HSA-9609646 | HCMV Infection | 1.069153e-03 | 2.971 |
| R-HSA-69275 | G2/M Transition | 1.333437e-03 | 2.875 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.400390e-03 | 2.854 |
| R-HSA-5617833 | Cilium Assembly | 1.469883e-03 | 2.833 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.943747e-03 | 2.711 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.231852e-03 | 2.651 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.296636e-03 | 2.639 |
| R-HSA-1640170 | Cell Cycle | 3.532500e-03 | 2.452 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 3.582761e-03 | 2.446 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.056995e-03 | 2.392 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.453512e-03 | 2.351 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 4.567177e-03 | 2.340 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 5.143391e-03 | 2.289 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 5.662064e-03 | 2.247 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.429358e-03 | 2.192 |
| R-HSA-9824446 | Viral Infection Pathways | 6.764365e-03 | 2.170 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 8.172727e-03 | 2.088 |
| R-HSA-597592 | Post-translational protein modification | 8.038152e-03 | 2.095 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 8.865364e-03 | 2.052 |
| R-HSA-913531 | Interferon Signaling | 9.600357e-03 | 2.018 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.024138e-02 | 1.990 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.097968e-02 | 1.959 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.347837e-02 | 1.870 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.354280e-02 | 1.868 |
| R-HSA-9659379 | Sensory processing of sound | 1.467691e-02 | 1.833 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.489939e-02 | 1.827 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.620316e-02 | 1.790 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.822751e-02 | 1.739 |
| R-HSA-199991 | Membrane Trafficking | 1.639285e-02 | 1.785 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.892984e-02 | 1.723 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.296996e-02 | 1.639 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.318985e-02 | 1.635 |
| R-HSA-112316 | Neuronal System | 2.462738e-02 | 1.609 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.566193e-02 | 1.591 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.635426e-02 | 1.579 |
| R-HSA-168255 | Influenza Infection | 2.913972e-02 | 1.536 |
| R-HSA-3371568 | Attenuation phase | 3.119004e-02 | 1.506 |
| R-HSA-447038 | NrCAM interactions | 4.004689e-02 | 1.397 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 4.004689e-02 | 1.397 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.101245e-02 | 1.387 |
| R-HSA-373752 | Netrin-1 signaling | 3.747457e-02 | 1.426 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.101245e-02 | 1.387 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 3.442457e-02 | 1.463 |
| R-HSA-8866376 | Reelin signalling pathway | 4.004689e-02 | 1.397 |
| R-HSA-392499 | Metabolism of proteins | 3.944139e-02 | 1.404 |
| R-HSA-1266738 | Developmental Biology | 3.494230e-02 | 1.457 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.871135e-02 | 1.412 |
| R-HSA-3371556 | Cellular response to heat stress | 4.499815e-02 | 1.347 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.557602e-02 | 1.341 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.700447e-02 | 1.328 |
| R-HSA-199920 | CREB phosphorylation | 5.119453e-02 | 1.291 |
| R-HSA-164944 | Nef and signal transduction | 5.119453e-02 | 1.291 |
| R-HSA-447043 | Neurofascin interactions | 5.119453e-02 | 1.291 |
| R-HSA-72731 | Recycling of eIF2:GDP | 5.672022e-02 | 1.246 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 5.672022e-02 | 1.246 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 6.221407e-02 | 1.206 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 6.221407e-02 | 1.206 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 6.767627e-02 | 1.170 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.352679e-02 | 1.197 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 6.221407e-02 | 1.206 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 6.767627e-02 | 1.170 |
| R-HSA-9753281 | Paracetamol ADME | 5.280543e-02 | 1.277 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 6.832856e-02 | 1.165 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 7.310698e-02 | 1.136 |
| R-HSA-164843 | 2-LTR circle formation | 7.310698e-02 | 1.136 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 7.850640e-02 | 1.105 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 9.979464e-02 | 1.001 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 1.050402e-01 | 0.979 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.154408e-01 | 0.938 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 1.257218e-01 | 0.901 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.358846e-01 | 0.867 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.409221e-01 | 0.851 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.897257e-01 | 0.722 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.944525e-01 | 0.711 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.944525e-01 | 0.711 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.038244e-01 | 0.691 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.038244e-01 | 0.691 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.084699e-01 | 0.681 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.049001e-01 | 0.979 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.049001e-01 | 0.979 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.161529e-01 | 0.935 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.180575e-01 | 0.928 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.257539e-01 | 0.900 |
| R-HSA-192823 | Viral mRNA Translation | 1.434846e-01 | 0.843 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 1.535528e-01 | 0.814 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.555830e-01 | 0.808 |
| R-HSA-72172 | mRNA Splicing | 1.435069e-01 | 0.843 |
| R-HSA-3928664 | Ephrin signaling | 1.257218e-01 | 0.901 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.289203e-01 | 0.890 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.375150e-01 | 0.862 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 9.451864e-02 | 1.024 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.637552e-01 | 0.786 |
| R-HSA-156902 | Peptide chain elongation | 1.104880e-01 | 0.957 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.637552e-01 | 0.786 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.826626e-02 | 1.008 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.102556e-01 | 0.958 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.753800e-01 | 0.756 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.012198e-01 | 0.995 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.276966e-01 | 0.894 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.050402e-01 | 0.979 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.154408e-01 | 0.938 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.555830e-01 | 0.808 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.509100e-01 | 0.821 |
| R-HSA-72764 | Eukaryotic Translation Termination | 1.276966e-01 | 0.894 |
| R-HSA-2424491 | DAP12 signaling | 1.897257e-01 | 0.722 |
| R-HSA-525793 | Myogenesis | 1.705424e-01 | 0.768 |
| R-HSA-73864 | RNA Polymerase I Transcription | 9.040963e-02 | 1.044 |
| R-HSA-373753 | Nephrin family interactions | 1.358846e-01 | 0.867 |
| R-HSA-192814 | vRNA Synthesis | 7.850640e-02 | 1.105 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 8.387470e-02 | 1.076 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 8.387470e-02 | 1.076 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 9.451864e-02 | 1.024 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.050402e-01 | 0.979 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 1.459305e-01 | 0.836 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 1.509100e-01 | 0.821 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.276966e-01 | 0.894 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 1.897257e-01 | 0.722 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.199701e-01 | 0.921 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.308179e-01 | 0.883 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 1.358846e-01 | 0.867 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 1.509100e-01 | 0.821 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.084699e-01 | 0.681 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.495085e-01 | 0.825 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 9.451864e-02 | 1.024 |
| R-HSA-1433559 | Regulation of KIT signaling | 9.979464e-02 | 1.001 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.656768e-01 | 0.781 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.656768e-01 | 0.781 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 8.921205e-02 | 1.050 |
| R-HSA-198753 | ERK/MAPK targets | 1.409221e-01 | 0.851 |
| R-HSA-2408557 | Selenocysteine synthesis | 1.394986e-01 | 0.855 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.916881e-02 | 1.004 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.509100e-01 | 0.821 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 1.705424e-01 | 0.768 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 9.451864e-02 | 1.024 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.753800e-01 | 0.756 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.849714e-01 | 0.733 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.454867e-01 | 0.837 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 7.310698e-02 | 1.136 |
| R-HSA-9758890 | Transport of RCbl within the body | 7.850640e-02 | 1.105 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 1.753800e-01 | 0.756 |
| R-HSA-162592 | Integration of provirus | 8.387470e-02 | 1.076 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.414885e-01 | 0.849 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 9.979464e-02 | 1.001 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.050402e-01 | 0.979 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.038244e-01 | 0.691 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 1.753800e-01 | 0.756 |
| R-HSA-8953854 | Metabolism of RNA | 1.272735e-01 | 0.895 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 9.979464e-02 | 1.001 |
| R-HSA-210990 | PECAM1 interactions | 7.850640e-02 | 1.105 |
| R-HSA-73894 | DNA Repair | 7.213942e-02 | 1.142 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.212036e-01 | 0.916 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.929047e-01 | 0.715 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.205962e-01 | 0.919 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.607830e-01 | 0.794 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.607830e-01 | 0.794 |
| R-HSA-5693538 | Homology Directed Repair | 1.803192e-01 | 0.744 |
| R-HSA-72312 | rRNA processing | 1.828695e-01 | 0.738 |
| R-HSA-68875 | Mitotic Prophase | 1.845004e-01 | 0.734 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.753800e-01 | 0.756 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 1.409221e-01 | 0.851 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 1.656768e-01 | 0.781 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.991520e-01 | 0.701 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 1.931358e-01 | 0.714 |
| R-HSA-162906 | HIV Infection | 1.756315e-01 | 0.755 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.581537e-02 | 1.120 |
| R-HSA-196791 | Vitamin D (calciferol) metabolism | 1.257218e-01 | 0.901 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.558608e-01 | 0.807 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.558324e-01 | 0.807 |
| R-HSA-162582 | Signal Transduction | 1.643172e-01 | 0.784 |
| R-HSA-109582 | Hemostasis | 9.846646e-02 | 1.007 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.535528e-01 | 0.814 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.535528e-01 | 0.814 |
| R-HSA-5663205 | Infectious disease | 1.226265e-01 | 0.911 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.067539e-01 | 0.972 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.180575e-01 | 0.928 |
| R-HSA-9020591 | Interleukin-12 signaling | 8.688773e-02 | 1.061 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.086166e-01 | 0.964 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.130885e-01 | 0.671 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 2.130885e-01 | 0.671 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.130885e-01 | 0.671 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.130885e-01 | 0.671 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.176805e-01 | 0.662 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.216857e-01 | 0.654 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.222459e-01 | 0.653 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.222459e-01 | 0.653 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.222459e-01 | 0.653 |
| R-HSA-3371511 | HSF1 activation | 2.222459e-01 | 0.653 |
| R-HSA-111933 | Calmodulin induced events | 2.222459e-01 | 0.653 |
| R-HSA-111997 | CaM pathway | 2.222459e-01 | 0.653 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.248131e-01 | 0.648 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.267850e-01 | 0.644 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.291025e-01 | 0.640 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.312978e-01 | 0.636 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.357846e-01 | 0.627 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.357846e-01 | 0.627 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.402455e-01 | 0.619 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.402455e-01 | 0.619 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.402455e-01 | 0.619 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.402455e-01 | 0.619 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.420031e-01 | 0.616 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.446807e-01 | 0.611 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.446807e-01 | 0.611 |
| R-HSA-9607240 | FLT3 Signaling | 2.446807e-01 | 0.611 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 2.490902e-01 | 0.604 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 2.490902e-01 | 0.604 |
| R-HSA-166520 | Signaling by NTRKs | 2.527805e-01 | 0.597 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.534742e-01 | 0.596 |
| R-HSA-111996 | Ca-dependent events | 2.534742e-01 | 0.596 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.534742e-01 | 0.596 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.578330e-01 | 0.589 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.614127e-01 | 0.583 |
| R-HSA-2172127 | DAP12 interactions | 2.621665e-01 | 0.581 |
| R-HSA-9907900 | Proteasome assembly | 2.621665e-01 | 0.581 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.621665e-01 | 0.581 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.621665e-01 | 0.581 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 2.621665e-01 | 0.581 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.664750e-01 | 0.574 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 2.664750e-01 | 0.574 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.664750e-01 | 0.574 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 2.707586e-01 | 0.567 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.707586e-01 | 0.567 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 2.707586e-01 | 0.567 |
| R-HSA-162587 | HIV Life Cycle | 2.722077e-01 | 0.565 |
| R-HSA-9711097 | Cellular response to starvation | 2.743666e-01 | 0.562 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.750175e-01 | 0.561 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.750175e-01 | 0.561 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.792517e-01 | 0.554 |
| R-HSA-9766229 | Degradation of CDH1 | 2.834615e-01 | 0.548 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.873132e-01 | 0.542 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.959454e-01 | 0.529 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 2.959454e-01 | 0.529 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.959454e-01 | 0.529 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.959454e-01 | 0.529 |
| R-HSA-1221632 | Meiotic synapsis | 3.000587e-01 | 0.523 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.000587e-01 | 0.523 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.000587e-01 | 0.523 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.000587e-01 | 0.523 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 3.045387e-01 | 0.516 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.082141e-01 | 0.511 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.122565e-01 | 0.505 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.122565e-01 | 0.505 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.122565e-01 | 0.505 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 3.122565e-01 | 0.505 |
| R-HSA-1500931 | Cell-Cell communication | 3.127489e-01 | 0.505 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.162755e-01 | 0.500 |
| R-HSA-5621480 | Dectin-2 family | 3.162755e-01 | 0.500 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.162755e-01 | 0.500 |
| R-HSA-191859 | snRNP Assembly | 3.242440e-01 | 0.489 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.242440e-01 | 0.489 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.242440e-01 | 0.489 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 3.242440e-01 | 0.489 |
| R-HSA-449147 | Signaling by Interleukins | 3.255715e-01 | 0.487 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.281936e-01 | 0.484 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.281936e-01 | 0.484 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.321205e-01 | 0.479 |
| R-HSA-450294 | MAP kinase activation | 3.321205e-01 | 0.479 |
| R-HSA-112043 | PLC beta mediated events | 3.321205e-01 | 0.479 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.360246e-01 | 0.474 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.360246e-01 | 0.474 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.399062e-01 | 0.469 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.399062e-01 | 0.469 |
| R-HSA-373755 | Semaphorin interactions | 3.399062e-01 | 0.469 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.472288e-01 | 0.459 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.476021e-01 | 0.459 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.514167e-01 | 0.454 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.552092e-01 | 0.450 |
| R-HSA-112040 | G-protein mediated events | 3.552092e-01 | 0.450 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 3.552092e-01 | 0.450 |
| R-HSA-448424 | Interleukin-17 signaling | 3.664556e-01 | 0.436 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.701611e-01 | 0.432 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.701611e-01 | 0.432 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.701611e-01 | 0.432 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 3.701611e-01 | 0.432 |
| R-HSA-975634 | Retinoid metabolism and transport | 3.701611e-01 | 0.432 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.724524e-01 | 0.429 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.738452e-01 | 0.427 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.738452e-01 | 0.427 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.738452e-01 | 0.427 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.775079e-01 | 0.423 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.775079e-01 | 0.423 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.775079e-01 | 0.423 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.811494e-01 | 0.419 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.820826e-01 | 0.418 |
| R-HSA-380287 | Centrosome maturation | 3.847699e-01 | 0.415 |
| R-HSA-8852135 | Protein ubiquitination | 3.847699e-01 | 0.415 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.847699e-01 | 0.415 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.883694e-01 | 0.411 |
| R-HSA-5689603 | UCH proteinases | 3.883694e-01 | 0.411 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.955060e-01 | 0.403 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.025603e-01 | 0.395 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.025603e-01 | 0.395 |
| R-HSA-418990 | Adherens junctions interactions | 4.054719e-01 | 0.392 |
| R-HSA-9748784 | Drug ADME | 4.054719e-01 | 0.392 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.060568e-01 | 0.391 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 4.060568e-01 | 0.391 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.095330e-01 | 0.388 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.164253e-01 | 0.380 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 4.164253e-01 | 0.380 |
| R-HSA-1500620 | Meiosis | 4.198415e-01 | 0.377 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.198415e-01 | 0.377 |
| R-HSA-1280218 | Adaptive Immune System | 4.315660e-01 | 0.365 |
| R-HSA-9645723 | Diseases of programmed cell death | 4.333096e-01 | 0.363 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.399272e-01 | 0.357 |
| R-HSA-73884 | Base Excision Repair | 4.399272e-01 | 0.357 |
| R-HSA-8939211 | ESR-mediated signaling | 4.435931e-01 | 0.353 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.497105e-01 | 0.347 |
| R-HSA-2029481 | FCGR activation | 4.529339e-01 | 0.344 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 4.529339e-01 | 0.344 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.561386e-01 | 0.341 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 4.656416e-01 | 0.332 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.687726e-01 | 0.329 |
| R-HSA-421270 | Cell-cell junction organization | 4.708214e-01 | 0.327 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.718855e-01 | 0.326 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.718855e-01 | 0.326 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.718855e-01 | 0.326 |
| R-HSA-3214847 | HATs acetylate histones | 4.749803e-01 | 0.323 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.749803e-01 | 0.323 |
| R-HSA-70171 | Glycolysis | 4.780572e-01 | 0.321 |
| R-HSA-5688426 | Deubiquitination | 4.784569e-01 | 0.320 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.841576e-01 | 0.315 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.841576e-01 | 0.315 |
| R-HSA-1483255 | PI Metabolism | 4.841576e-01 | 0.315 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.901874e-01 | 0.310 |
| R-HSA-111885 | Opioid Signalling | 4.901874e-01 | 0.310 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.901874e-01 | 0.310 |
| R-HSA-72766 | Translation | 4.905029e-01 | 0.309 |
| R-HSA-9833110 | RSV-host interactions | 4.931761e-01 | 0.307 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.961474e-01 | 0.304 |
| R-HSA-211000 | Gene Silencing by RNA | 5.020385e-01 | 0.299 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.049585e-01 | 0.297 |
| R-HSA-1643685 | Disease | 5.055418e-01 | 0.296 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.078615e-01 | 0.294 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.107477e-01 | 0.292 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.107477e-01 | 0.292 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.164699e-01 | 0.287 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.193061e-01 | 0.285 |
| R-HSA-446728 | Cell junction organization | 5.210473e-01 | 0.283 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.221258e-01 | 0.282 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.221258e-01 | 0.282 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.277163e-01 | 0.278 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.304872e-01 | 0.275 |
| R-HSA-70326 | Glucose metabolism | 5.359810e-01 | 0.271 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.387039e-01 | 0.269 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.414111e-01 | 0.266 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.414111e-01 | 0.266 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.494385e-01 | 0.260 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.494385e-01 | 0.260 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.520833e-01 | 0.258 |
| R-HSA-194138 | Signaling by VEGF | 5.599260e-01 | 0.252 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 5.625099e-01 | 0.250 |
| R-HSA-69481 | G2/M Checkpoints | 5.650787e-01 | 0.248 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.676327e-01 | 0.246 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.726962e-01 | 0.242 |
| R-HSA-1474165 | Reproduction | 5.752059e-01 | 0.240 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 5.801816e-01 | 0.236 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.947654e-01 | 0.226 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.975160e-01 | 0.224 |
| R-HSA-9664407 | Parasite infection | 6.018682e-01 | 0.220 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.018682e-01 | 0.220 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.018682e-01 | 0.220 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.088478e-01 | 0.215 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.088478e-01 | 0.215 |
| R-HSA-211859 | Biological oxidations | 6.192291e-01 | 0.208 |
| R-HSA-2187338 | Visual phototransduction | 6.202124e-01 | 0.207 |
| R-HSA-69242 | S Phase | 6.224458e-01 | 0.206 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.224458e-01 | 0.206 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 6.268737e-01 | 0.203 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.268737e-01 | 0.203 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.269852e-01 | 0.203 |
| R-HSA-73887 | Death Receptor Signaling | 6.355760e-01 | 0.197 |
| R-HSA-9610379 | HCMV Late Events | 6.419706e-01 | 0.192 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.440774e-01 | 0.191 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.482542e-01 | 0.188 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.576084e-01 | 0.182 |
| R-HSA-5619102 | SLC transporter disorders | 6.624948e-01 | 0.179 |
| R-HSA-72306 | tRNA processing | 6.703746e-01 | 0.174 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.761647e-01 | 0.170 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.761647e-01 | 0.170 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.761647e-01 | 0.170 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.761647e-01 | 0.170 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.761647e-01 | 0.170 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.780723e-01 | 0.169 |
| R-HSA-168256 | Immune System | 6.801420e-01 | 0.167 |
| R-HSA-2559583 | Cellular Senescence | 6.892866e-01 | 0.162 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.105685e-01 | 0.148 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.173369e-01 | 0.144 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.204933e-01 | 0.142 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.288067e-01 | 0.137 |
| R-HSA-397014 | Muscle contraction | 7.443976e-01 | 0.128 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.647455e-01 | 0.116 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.675184e-01 | 0.115 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.702589e-01 | 0.113 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.756445e-01 | 0.110 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 7.796015e-01 | 0.108 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.922994e-01 | 0.101 |
| R-HSA-4839726 | Chromatin organization | 7.947507e-01 | 0.100 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.031071e-01 | 0.095 |
| R-HSA-168249 | Innate Immune System | 8.095567e-01 | 0.092 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.166563e-01 | 0.088 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.230808e-01 | 0.085 |
| R-HSA-9658195 | Leishmania infection | 8.302949e-01 | 0.081 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.302949e-01 | 0.081 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.381838e-01 | 0.077 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.438613e-01 | 0.074 |
| R-HSA-1483257 | Phospholipid metabolism | 8.438613e-01 | 0.074 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.447882e-01 | 0.073 |
| R-HSA-9679506 | SARS-CoV Infections | 8.537971e-01 | 0.069 |
| R-HSA-8957322 | Metabolism of steroids | 8.686424e-01 | 0.061 |
| R-HSA-1474244 | Extracellular matrix organization | 8.740154e-01 | 0.058 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.854935e-01 | 0.053 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.868535e-01 | 0.052 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.914044e-01 | 0.050 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.965565e-01 | 0.047 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.156070e-01 | 0.038 |
| R-HSA-418594 | G alpha (i) signalling events | 9.205176e-01 | 0.036 |
| R-HSA-8978868 | Fatty acid metabolism | 9.205176e-01 | 0.036 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.404243e-01 | 0.027 |
| R-HSA-6798695 | Neutrophil degranulation | 9.411368e-01 | 0.026 |
| R-HSA-9709957 | Sensory Perception | 9.417353e-01 | 0.026 |
| R-HSA-388396 | GPCR downstream signalling | 9.495799e-01 | 0.022 |
| R-HSA-74160 | Gene expression (Transcription) | 9.540882e-01 | 0.020 |
| R-HSA-372790 | Signaling by GPCR | 9.669829e-01 | 0.015 |
| R-HSA-556833 | Metabolism of lipids | 9.944735e-01 | 0.002 |
| R-HSA-212436 | Generic Transcription Pathway | 9.960286e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.976160e-01 | 0.001 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.981214e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.998419e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
DSTYK |
0.782 | 0.256 | 2 | 0.842 |
COT |
0.781 | 0.176 | 2 | 0.809 |
NEK6 |
0.777 | 0.236 | -2 | 0.731 |
TGFBR2 |
0.775 | 0.227 | -2 | 0.782 |
NEK7 |
0.773 | 0.211 | -3 | 0.800 |
IKKB |
0.771 | 0.052 | -2 | 0.501 |
IKKE |
0.767 | 0.139 | 1 | 0.787 |
TBK1 |
0.765 | 0.102 | 1 | 0.785 |
IKKA |
0.765 | 0.122 | -2 | 0.499 |
BMPR2 |
0.765 | 0.207 | -2 | 0.681 |
ULK2 |
0.765 | 0.046 | 2 | 0.701 |
RAF1 |
0.764 | 0.061 | 1 | 0.807 |
PIM3 |
0.764 | 0.025 | -3 | 0.747 |
GCN2 |
0.763 | 0.080 | 2 | 0.709 |
MTOR |
0.763 | 0.013 | 1 | 0.757 |
GRK7 |
0.762 | 0.167 | 1 | 0.707 |
MOS |
0.762 | 0.012 | 1 | 0.723 |
PLK1 |
0.762 | 0.245 | -2 | 0.795 |
CLK3 |
0.760 | 0.066 | 1 | 0.690 |
PRPK |
0.760 | -0.090 | -1 | 0.764 |
GRK1 |
0.760 | 0.065 | -2 | 0.564 |
MST4 |
0.760 | 0.033 | 2 | 0.822 |
TGFBR1 |
0.759 | 0.094 | -2 | 0.655 |
ACVR2A |
0.759 | 0.226 | -2 | 0.777 |
FAM20C |
0.759 | 0.165 | 2 | 0.708 |
NLK |
0.758 | -0.025 | 1 | 0.747 |
PDHK1 |
0.757 | -0.019 | 1 | 0.824 |
ACVR2B |
0.757 | 0.210 | -2 | 0.769 |
ATR |
0.756 | -0.033 | 1 | 0.717 |
CAMK2G |
0.756 | -0.022 | 2 | 0.757 |
CDC7 |
0.755 | -0.041 | 1 | 0.665 |
BMPR1B |
0.755 | 0.098 | 1 | 0.630 |
PDHK4 |
0.755 | -0.108 | 1 | 0.797 |
MARK4 |
0.754 | 0.014 | 4 | 0.919 |
SRPK1 |
0.753 | 0.056 | -3 | 0.698 |
CAMK1B |
0.753 | -0.065 | -3 | 0.785 |
PKN3 |
0.753 | -0.016 | -3 | 0.782 |
CDKL1 |
0.753 | 0.002 | -3 | 0.754 |
MLK1 |
0.752 | 0.007 | 2 | 0.755 |
ALK4 |
0.752 | 0.042 | -2 | 0.660 |
SRPK3 |
0.752 | 0.097 | -3 | 0.675 |
NEK9 |
0.751 | 0.021 | 2 | 0.767 |
PKCD |
0.751 | 0.030 | 2 | 0.747 |
PIM1 |
0.751 | 0.024 | -3 | 0.699 |
PRKD1 |
0.750 | -0.028 | -3 | 0.758 |
NDR2 |
0.750 | -0.037 | -3 | 0.751 |
KIS |
0.750 | 0.042 | 1 | 0.609 |
ULK1 |
0.749 | -0.020 | -3 | 0.795 |
ANKRD3 |
0.749 | 0.023 | 1 | 0.791 |
NUAK2 |
0.748 | -0.035 | -3 | 0.769 |
LATS1 |
0.748 | 0.090 | -3 | 0.757 |
CAMLCK |
0.748 | -0.061 | -2 | 0.584 |
ALK2 |
0.748 | 0.074 | -2 | 0.676 |
NIK |
0.748 | -0.099 | -3 | 0.790 |
SRPK2 |
0.748 | 0.075 | -3 | 0.632 |
GRK4 |
0.748 | 0.028 | -2 | 0.665 |
ERK5 |
0.748 | -0.063 | 1 | 0.721 |
PERK |
0.748 | 0.177 | -2 | 0.743 |
TLK2 |
0.747 | 0.116 | 1 | 0.730 |
BCKDK |
0.747 | -0.048 | -1 | 0.693 |
HIPK4 |
0.747 | -0.011 | 1 | 0.671 |
GRK5 |
0.747 | -0.102 | -3 | 0.750 |
RSK2 |
0.746 | -0.012 | -3 | 0.712 |
CDKL5 |
0.746 | -0.014 | -3 | 0.754 |
CHAK2 |
0.746 | -0.025 | -1 | 0.686 |
DAPK2 |
0.745 | -0.079 | -3 | 0.798 |
YSK4 |
0.745 | 0.035 | 1 | 0.773 |
HRI |
0.745 | 0.143 | -2 | 0.747 |
PKR |
0.745 | 0.030 | 1 | 0.753 |
WNK1 |
0.745 | -0.103 | -2 | 0.530 |
ICK |
0.745 | -0.022 | -3 | 0.779 |
PLK3 |
0.744 | 0.106 | 2 | 0.688 |
SKMLCK |
0.744 | -0.071 | -2 | 0.565 |
NDR1 |
0.743 | -0.067 | -3 | 0.747 |
ATM |
0.743 | -0.005 | 1 | 0.645 |
PRKD2 |
0.743 | -0.024 | -3 | 0.711 |
AMPKA1 |
0.743 | -0.062 | -3 | 0.772 |
RSK3 |
0.743 | -0.021 | -3 | 0.710 |
CAMK2D |
0.743 | -0.067 | -3 | 0.778 |
HUNK |
0.742 | -0.103 | 2 | 0.694 |
TTBK2 |
0.742 | -0.032 | 2 | 0.615 |
PLK4 |
0.742 | 0.106 | 2 | 0.504 |
PKCA |
0.742 | 0.014 | 2 | 0.702 |
P70S6KB |
0.742 | -0.046 | -3 | 0.731 |
PKN2 |
0.741 | -0.068 | -3 | 0.760 |
PKACG |
0.741 | -0.040 | -2 | 0.535 |
GRK6 |
0.741 | -0.054 | 1 | 0.741 |
TSSK1 |
0.740 | -0.045 | -3 | 0.790 |
NEK2 |
0.740 | -0.029 | 2 | 0.753 |
LATS2 |
0.740 | -0.053 | -5 | 0.345 |
QSK |
0.740 | 0.013 | 4 | 0.904 |
AURC |
0.740 | -0.020 | -2 | 0.467 |
MLK3 |
0.740 | 0.007 | 2 | 0.706 |
MASTL |
0.739 | -0.180 | -2 | 0.557 |
DLK |
0.739 | -0.123 | 1 | 0.761 |
CDK1 |
0.739 | 0.021 | 1 | 0.539 |
MARK2 |
0.739 | 0.033 | 4 | 0.866 |
P90RSK |
0.739 | -0.038 | -3 | 0.724 |
CAMK2B |
0.739 | -0.013 | 2 | 0.751 |
BMPR1A |
0.739 | 0.072 | 1 | 0.607 |
WNK3 |
0.738 | -0.148 | 1 | 0.776 |
MLK2 |
0.737 | -0.109 | 2 | 0.756 |
CDK8 |
0.737 | -0.025 | 1 | 0.589 |
MEK1 |
0.737 | -0.075 | 2 | 0.740 |
PKG2 |
0.737 | -0.024 | -2 | 0.491 |
PKACB |
0.736 | 0.001 | -2 | 0.496 |
RIPK3 |
0.736 | -0.151 | 3 | 0.644 |
DNAPK |
0.736 | 0.004 | 1 | 0.680 |
MAPKAPK3 |
0.736 | -0.087 | -3 | 0.709 |
TAO3 |
0.736 | 0.079 | 1 | 0.763 |
AURA |
0.735 | -0.011 | -2 | 0.453 |
AURB |
0.735 | -0.032 | -2 | 0.466 |
TSSK2 |
0.735 | -0.117 | -5 | 0.360 |
TLK1 |
0.735 | 0.065 | -2 | 0.733 |
CDK5 |
0.735 | 0.008 | 1 | 0.605 |
VRK2 |
0.735 | -0.133 | 1 | 0.782 |
MARK3 |
0.735 | 0.011 | 4 | 0.877 |
SIK |
0.735 | 0.002 | -3 | 0.692 |
AMPKA2 |
0.735 | -0.062 | -3 | 0.746 |
PIM2 |
0.735 | -0.006 | -3 | 0.698 |
NIM1 |
0.735 | -0.060 | 3 | 0.700 |
MEKK1 |
0.735 | 0.014 | 1 | 0.777 |
MLK4 |
0.734 | 0.025 | 2 | 0.665 |
MAPKAPK2 |
0.734 | -0.035 | -3 | 0.656 |
PKCG |
0.733 | -0.035 | 2 | 0.697 |
PKCB |
0.733 | -0.020 | 2 | 0.704 |
QIK |
0.733 | -0.079 | -3 | 0.775 |
IRE1 |
0.733 | -0.089 | 1 | 0.703 |
MPSK1 |
0.733 | 0.033 | 1 | 0.761 |
MEKK2 |
0.733 | 0.042 | 2 | 0.721 |
CDK2 |
0.733 | 0.004 | 1 | 0.637 |
CDK3 |
0.732 | 0.038 | 1 | 0.498 |
SGK3 |
0.731 | -0.025 | -3 | 0.708 |
PRKX |
0.731 | 0.024 | -3 | 0.618 |
CLK4 |
0.731 | -0.017 | -3 | 0.699 |
PRKD3 |
0.731 | -0.047 | -3 | 0.689 |
RSK4 |
0.731 | -0.017 | -3 | 0.689 |
NUAK1 |
0.731 | -0.050 | -3 | 0.724 |
PINK1 |
0.730 | -0.043 | 1 | 0.734 |
NEK5 |
0.730 | -0.005 | 1 | 0.768 |
RIPK1 |
0.730 | -0.201 | 1 | 0.726 |
IRE2 |
0.730 | -0.054 | 2 | 0.682 |
DYRK2 |
0.730 | -0.037 | 1 | 0.604 |
JNK3 |
0.730 | -0.013 | 1 | 0.573 |
BRAF |
0.729 | -0.038 | -4 | 0.775 |
MEKK3 |
0.729 | -0.046 | 1 | 0.763 |
MST2 |
0.729 | 0.090 | 1 | 0.794 |
CDK19 |
0.729 | -0.031 | 1 | 0.557 |
MARK1 |
0.729 | -0.013 | 4 | 0.882 |
AKT2 |
0.729 | -0.008 | -3 | 0.645 |
PAK1 |
0.729 | -0.085 | -2 | 0.508 |
PKCH |
0.729 | -0.046 | 2 | 0.673 |
GAK |
0.728 | 0.062 | 1 | 0.815 |
CAMK2A |
0.728 | -0.056 | 2 | 0.750 |
CHAK1 |
0.728 | -0.084 | 2 | 0.713 |
CLK1 |
0.728 | -0.007 | -3 | 0.684 |
MNK2 |
0.728 | -0.082 | -2 | 0.523 |
MSK2 |
0.727 | -0.055 | -3 | 0.680 |
CLK2 |
0.727 | 0.029 | -3 | 0.673 |
P38B |
0.727 | -0.027 | 1 | 0.566 |
ZAK |
0.727 | -0.061 | 1 | 0.750 |
PAK6 |
0.727 | -0.049 | -2 | 0.441 |
MST3 |
0.726 | -0.033 | 2 | 0.786 |
P38A |
0.726 | -0.044 | 1 | 0.631 |
PAK3 |
0.726 | -0.115 | -2 | 0.505 |
PKCZ |
0.726 | -0.069 | 2 | 0.729 |
JNK2 |
0.726 | -0.021 | 1 | 0.550 |
CHK1 |
0.726 | -0.111 | -3 | 0.739 |
NEK8 |
0.726 | 0.006 | 2 | 0.751 |
SMG1 |
0.726 | -0.099 | 1 | 0.680 |
CDK7 |
0.725 | -0.065 | 1 | 0.589 |
PRP4 |
0.725 | 0.001 | -3 | 0.715 |
MSK1 |
0.725 | -0.041 | -3 | 0.689 |
TNIK |
0.725 | 0.084 | 3 | 0.828 |
CAMK4 |
0.725 | -0.157 | -3 | 0.736 |
MELK |
0.724 | -0.111 | -3 | 0.737 |
PHKG1 |
0.724 | -0.081 | -3 | 0.732 |
P38G |
0.724 | -0.019 | 1 | 0.478 |
GCK |
0.724 | 0.061 | 1 | 0.796 |
PKACA |
0.724 | -0.008 | -2 | 0.460 |
ERK1 |
0.724 | -0.035 | 1 | 0.562 |
BRSK1 |
0.723 | -0.048 | -3 | 0.719 |
CAMKK1 |
0.723 | -0.076 | -2 | 0.497 |
MYLK4 |
0.723 | -0.086 | -2 | 0.531 |
MEK5 |
0.723 | -0.151 | 2 | 0.738 |
MINK |
0.723 | 0.069 | 1 | 0.802 |
GRK2 |
0.723 | -0.080 | -2 | 0.546 |
HIPK1 |
0.723 | -0.035 | 1 | 0.629 |
CDK13 |
0.723 | -0.053 | 1 | 0.568 |
TAO2 |
0.722 | -0.027 | 2 | 0.804 |
BRSK2 |
0.722 | -0.072 | -3 | 0.740 |
PAK2 |
0.721 | -0.115 | -2 | 0.500 |
PLK2 |
0.721 | 0.066 | -3 | 0.624 |
TAK1 |
0.721 | 0.020 | 1 | 0.782 |
HGK |
0.721 | 0.032 | 3 | 0.816 |
MNK1 |
0.720 | -0.086 | -2 | 0.546 |
MST1 |
0.720 | 0.058 | 1 | 0.793 |
HIPK2 |
0.720 | -0.021 | 1 | 0.523 |
NEK4 |
0.719 | -0.025 | 1 | 0.781 |
CDK18 |
0.719 | -0.037 | 1 | 0.534 |
DCAMKL1 |
0.719 | -0.067 | -3 | 0.699 |
AKT1 |
0.719 | -0.016 | -3 | 0.657 |
PKCT |
0.719 | -0.048 | 2 | 0.684 |
WNK4 |
0.718 | -0.142 | -2 | 0.519 |
TTBK1 |
0.718 | -0.074 | 2 | 0.539 |
DRAK1 |
0.718 | -0.123 | 1 | 0.634 |
PDK1 |
0.717 | -0.058 | 1 | 0.728 |
CDK12 |
0.717 | -0.053 | 1 | 0.544 |
CAMKK2 |
0.717 | -0.108 | -2 | 0.479 |
KHS2 |
0.717 | 0.072 | 1 | 0.812 |
SMMLCK |
0.717 | -0.094 | -3 | 0.761 |
TTK |
0.716 | 0.236 | -2 | 0.815 |
HIPK3 |
0.716 | -0.059 | 1 | 0.643 |
DYRK1A |
0.716 | -0.044 | 1 | 0.638 |
CDK17 |
0.716 | -0.043 | 1 | 0.484 |
ERK7 |
0.716 | 0.001 | 2 | 0.548 |
EEF2K |
0.716 | -0.018 | 3 | 0.821 |
P38D |
0.716 | -0.015 | 1 | 0.490 |
CDK9 |
0.716 | -0.076 | 1 | 0.579 |
KHS1 |
0.716 | 0.060 | 1 | 0.807 |
MAPKAPK5 |
0.716 | -0.114 | -3 | 0.683 |
PASK |
0.715 | -0.082 | -3 | 0.773 |
ERK2 |
0.715 | -0.075 | 1 | 0.588 |
MAK |
0.715 | 0.012 | -2 | 0.430 |
LKB1 |
0.715 | -0.096 | -3 | 0.789 |
P70S6K |
0.715 | -0.066 | -3 | 0.673 |
HPK1 |
0.714 | 0.007 | 1 | 0.793 |
NEK11 |
0.714 | -0.109 | 1 | 0.762 |
IRAK4 |
0.714 | -0.143 | 1 | 0.719 |
GRK3 |
0.713 | -0.070 | -2 | 0.525 |
CK2A2 |
0.713 | 0.015 | 1 | 0.539 |
NEK1 |
0.713 | -0.048 | 1 | 0.760 |
LOK |
0.713 | -0.037 | -2 | 0.535 |
PKCE |
0.712 | -0.030 | 2 | 0.688 |
PKCI |
0.712 | -0.069 | 2 | 0.699 |
MEK2 |
0.712 | -0.057 | 2 | 0.706 |
CAMK1G |
0.712 | -0.099 | -3 | 0.709 |
SNRK |
0.712 | -0.179 | 2 | 0.579 |
MAP3K15 |
0.711 | -0.084 | 1 | 0.748 |
SSTK |
0.711 | -0.103 | 4 | 0.896 |
BIKE |
0.711 | 0.090 | 1 | 0.759 |
PHKG2 |
0.711 | -0.079 | -3 | 0.723 |
MRCKB |
0.710 | -0.024 | -3 | 0.683 |
DYRK3 |
0.710 | -0.045 | 1 | 0.626 |
MEKK6 |
0.710 | -0.099 | 1 | 0.763 |
ROCK2 |
0.710 | -0.020 | -3 | 0.712 |
SGK1 |
0.710 | -0.003 | -3 | 0.572 |
DCAMKL2 |
0.710 | -0.091 | -3 | 0.725 |
DYRK4 |
0.710 | -0.042 | 1 | 0.536 |
GSK3A |
0.709 | -0.020 | 4 | 0.415 |
DAPK3 |
0.709 | -0.062 | -3 | 0.717 |
OSR1 |
0.709 | 0.047 | 2 | 0.723 |
PBK |
0.709 | 0.026 | 1 | 0.780 |
VRK1 |
0.709 | -0.094 | 2 | 0.745 |
DYRK1B |
0.709 | -0.056 | 1 | 0.560 |
IRAK1 |
0.709 | -0.175 | -1 | 0.650 |
AKT3 |
0.709 | -0.009 | -3 | 0.586 |
JNK1 |
0.709 | -0.032 | 1 | 0.534 |
GSK3B |
0.708 | -0.045 | 4 | 0.408 |
CDK14 |
0.708 | -0.065 | 1 | 0.587 |
YSK1 |
0.707 | -0.043 | 2 | 0.757 |
SLK |
0.707 | -0.039 | -2 | 0.509 |
MRCKA |
0.707 | -0.041 | -3 | 0.684 |
CDK6 |
0.707 | -0.028 | 1 | 0.569 |
CAMK1D |
0.707 | -0.072 | -3 | 0.625 |
PAK5 |
0.706 | -0.077 | -2 | 0.411 |
LRRK2 |
0.706 | -0.139 | 2 | 0.779 |
BUB1 |
0.706 | -0.038 | -5 | 0.348 |
CK1G1 |
0.706 | -0.052 | -3 | 0.381 |
CK1D |
0.705 | -0.070 | -3 | 0.357 |
CDK16 |
0.704 | -0.045 | 1 | 0.505 |
CK1E |
0.703 | -0.097 | -3 | 0.401 |
CDK10 |
0.703 | -0.055 | 1 | 0.563 |
CHK2 |
0.702 | -0.046 | -3 | 0.588 |
NEK3 |
0.702 | -0.069 | 1 | 0.735 |
PKN1 |
0.701 | -0.063 | -3 | 0.683 |
AAK1 |
0.701 | 0.111 | 1 | 0.685 |
CDK4 |
0.701 | -0.050 | 1 | 0.539 |
PAK4 |
0.700 | -0.074 | -2 | 0.417 |
PKG1 |
0.700 | -0.033 | -2 | 0.435 |
DAPK1 |
0.700 | -0.080 | -3 | 0.711 |
MOK |
0.699 | -0.033 | 1 | 0.630 |
DMPK1 |
0.699 | -0.033 | -3 | 0.685 |
CK2A1 |
0.698 | -0.019 | 1 | 0.517 |
MYO3A |
0.698 | 0.021 | 1 | 0.756 |
RIPK2 |
0.698 | -0.163 | 1 | 0.720 |
MYO3B |
0.697 | -0.009 | 2 | 0.778 |
CK1A2 |
0.697 | -0.090 | -3 | 0.358 |
ROCK1 |
0.697 | -0.034 | -3 | 0.683 |
TAO1 |
0.696 | -0.025 | 1 | 0.725 |
STK33 |
0.695 | -0.139 | 2 | 0.533 |
CAMK1A |
0.695 | -0.072 | -3 | 0.599 |
SBK |
0.695 | -0.034 | -3 | 0.540 |
CRIK |
0.690 | -0.044 | -3 | 0.665 |
ALPHAK3 |
0.690 | 0.007 | -1 | 0.671 |
ASK1 |
0.690 | -0.109 | 1 | 0.736 |
STLK3 |
0.681 | -0.079 | 1 | 0.735 |
PDHK3_TYR |
0.681 | 0.076 | 4 | 0.876 |
HASPIN |
0.681 | -0.092 | -1 | 0.543 |
MAP2K4_TYR |
0.676 | 0.039 | -1 | 0.775 |
YANK3 |
0.676 | -0.072 | 2 | 0.355 |
BMPR2_TYR |
0.673 | 0.013 | -1 | 0.759 |
MAP2K6_TYR |
0.672 | 0.033 | -1 | 0.755 |
PKMYT1_TYR |
0.672 | -0.049 | 3 | 0.786 |
MAP2K7_TYR |
0.670 | -0.116 | 2 | 0.780 |
TESK1_TYR |
0.670 | -0.119 | 3 | 0.826 |
TYK2 |
0.670 | -0.003 | 1 | 0.780 |
LCK |
0.670 | 0.110 | -1 | 0.803 |
PDHK1_TYR |
0.670 | 0.001 | -1 | 0.782 |
PDHK4_TYR |
0.669 | -0.015 | 2 | 0.810 |
PINK1_TYR |
0.669 | -0.083 | 1 | 0.752 |
BLK |
0.669 | 0.124 | -1 | 0.801 |
YES1 |
0.669 | 0.073 | -1 | 0.819 |
TXK |
0.668 | 0.105 | 1 | 0.704 |
HCK |
0.667 | 0.062 | -1 | 0.795 |
FGR |
0.667 | 0.022 | 1 | 0.801 |
JAK2 |
0.666 | -0.007 | 1 | 0.773 |
EPHA6 |
0.666 | -0.030 | -1 | 0.766 |
RET |
0.665 | -0.057 | 1 | 0.771 |
FYN |
0.665 | 0.109 | -1 | 0.794 |
ABL2 |
0.665 | 0.029 | -1 | 0.755 |
LIMK2_TYR |
0.665 | -0.086 | -3 | 0.809 |
JAK1 |
0.664 | 0.049 | 1 | 0.751 |
MST1R |
0.663 | -0.059 | 3 | 0.724 |
CK1A |
0.663 | -0.088 | -3 | 0.264 |
ROS1 |
0.662 | -0.042 | 3 | 0.692 |
LIMK1_TYR |
0.662 | -0.117 | 2 | 0.787 |
EPHB4 |
0.661 | -0.042 | -1 | 0.746 |
CSF1R |
0.661 | -0.022 | 3 | 0.695 |
CK1G3 |
0.660 | -0.054 | -3 | 0.224 |
NEK10_TYR |
0.660 | 0.015 | 1 | 0.676 |
ABL1 |
0.659 | -0.003 | -1 | 0.768 |
TYRO3 |
0.659 | -0.086 | 3 | 0.729 |
ITK |
0.658 | 0.006 | -1 | 0.746 |
FER |
0.658 | -0.047 | 1 | 0.764 |
SRMS |
0.658 | -0.005 | 1 | 0.742 |
FLT3 |
0.656 | -0.014 | 3 | 0.716 |
TNNI3K_TYR |
0.655 | -0.046 | 1 | 0.755 |
SRC |
0.655 | 0.067 | -1 | 0.814 |
LYN |
0.654 | 0.041 | 3 | 0.634 |
PTK6 |
0.654 | -0.020 | -1 | 0.701 |
DDR1 |
0.654 | -0.160 | 4 | 0.850 |
BTK |
0.654 | -0.034 | -1 | 0.725 |
TEC |
0.654 | 0.016 | -1 | 0.729 |
EPHB2 |
0.654 | -0.020 | -1 | 0.743 |
EPHA4 |
0.653 | -0.042 | 2 | 0.705 |
KIT |
0.652 | -0.050 | 3 | 0.698 |
PDGFRB |
0.652 | -0.073 | 3 | 0.718 |
JAK3 |
0.652 | -0.097 | 1 | 0.726 |
BMX |
0.652 | -0.014 | -1 | 0.675 |
EPHB3 |
0.651 | -0.069 | -1 | 0.740 |
EPHB1 |
0.651 | -0.069 | 1 | 0.740 |
INSRR |
0.650 | -0.049 | 3 | 0.654 |
TNK2 |
0.648 | -0.084 | 3 | 0.642 |
FGFR1 |
0.648 | -0.092 | 3 | 0.675 |
KDR |
0.648 | -0.087 | 3 | 0.655 |
FRK |
0.648 | -0.019 | -1 | 0.792 |
ERBB2 |
0.648 | -0.051 | 1 | 0.754 |
FGFR2 |
0.648 | -0.105 | 3 | 0.694 |
MET |
0.647 | -0.050 | 3 | 0.680 |
WEE1_TYR |
0.647 | -0.078 | -1 | 0.667 |
CK1G2 |
0.646 | -0.066 | -3 | 0.308 |
EGFR |
0.646 | 0.008 | 1 | 0.677 |
AXL |
0.646 | -0.103 | 3 | 0.671 |
MERTK |
0.646 | -0.073 | 3 | 0.675 |
ALK |
0.645 | -0.079 | 3 | 0.630 |
TNK1 |
0.644 | -0.121 | 3 | 0.703 |
LTK |
0.644 | -0.082 | 3 | 0.658 |
PDGFRA |
0.644 | -0.129 | 3 | 0.723 |
TEK |
0.643 | -0.119 | 3 | 0.646 |
YANK2 |
0.643 | -0.094 | 2 | 0.374 |
FLT1 |
0.643 | -0.059 | -1 | 0.721 |
NTRK1 |
0.643 | -0.092 | -1 | 0.719 |
NTRK3 |
0.642 | -0.061 | -1 | 0.679 |
EPHA7 |
0.642 | -0.070 | 2 | 0.704 |
NTRK2 |
0.642 | -0.084 | 3 | 0.657 |
PTK2B |
0.641 | -0.026 | -1 | 0.782 |
EPHA3 |
0.640 | -0.095 | 2 | 0.673 |
EPHA8 |
0.640 | -0.032 | -1 | 0.729 |
EPHA1 |
0.639 | -0.102 | 3 | 0.657 |
FGFR4 |
0.639 | -0.018 | -1 | 0.704 |
INSR |
0.638 | -0.095 | 3 | 0.637 |
MATK |
0.637 | -0.070 | -1 | 0.678 |
SYK |
0.637 | 0.003 | -1 | 0.677 |
FGFR3 |
0.637 | -0.103 | 3 | 0.664 |
EPHA5 |
0.636 | -0.057 | 2 | 0.688 |
PTK2 |
0.635 | -0.014 | -1 | 0.688 |
FLT4 |
0.635 | -0.116 | 3 | 0.665 |
CSK |
0.635 | -0.083 | 2 | 0.697 |
DDR2 |
0.633 | -0.103 | 3 | 0.629 |
MUSK |
0.632 | -0.073 | 1 | 0.677 |
EPHA2 |
0.626 | -0.068 | -1 | 0.684 |
ERBB4 |
0.626 | -0.023 | 1 | 0.666 |
IGF1R |
0.625 | -0.080 | 3 | 0.577 |
ZAP70 |
0.618 | -0.026 | -1 | 0.603 |
FES |
0.613 | -0.099 | -1 | 0.688 |