Motif 688 (n=144)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1X283 | SH3PXD2B | S679 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
| O15258 | RER1 | S90 | ochoa | Protein RER1 | Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. {ECO:0000250}. |
| O43164 | PJA2 | S88 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43491 | EPB41L2 | S562 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O60563 | CCNT1 | S363 | ochoa | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O60701 | UGDH | S381 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O75140 | DEPDC5 | S442 | ochoa | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
| O75140 | DEPDC5 | S525 | ochoa | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
| O75363 | BCAS1 | S115 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75582 | RPS6KA5 | S628 | ochoa | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| O75995 | SASH3 | S193 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O76080 | ZFAND5 | S72 | ochoa | AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}. |
| O94885 | SASH1 | S574 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94915 | FRYL | S1337 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O95071 | UBR5 | S2011 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95613 | PCNT | S2433 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P06241 | FYN | S21 | ochoa|psp | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P08670 | VIM | S87 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P13693 | TPT1 | S46 | psp | Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23) | Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344). {ECO:0000269|PubMed:12167714, ECO:0000269|PubMed:15162379, ECO:0000269|PubMed:15958728, ECO:0000269|PubMed:18325344}. |
| P17174 | GOT1 | S66 | ochoa | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
| P17661 | DES | S92 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P17987 | TCP1 | S240 | ochoa | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P18583 | SON | S1631 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19838 | NFKB1 | S20 | psp | Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}. |
| P21333 | FLNA | S219 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S2163 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P35609 | ACTN2 | S624 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35611 | ADD1 | S532 | ochoa | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P38936 | CDKN1A | S114 | psp | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P40227 | CCT6A | S205 | ochoa | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P42575 | CASP2 | S139 | psp | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). {ECO:0000269|PubMed:11156409, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 1]: Acts as a positive regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 2]: Acts as a negative regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. {ECO:0000269|PubMed:11156409}. |
| P46781 | RPS9 | S160 | ochoa | Small ribosomal subunit protein uS4 (40S ribosomal protein S9) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P51452 | DUSP3 | S24 | ochoa | Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) | Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:10224087, PubMed:11863439). {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}. |
| P52566 | ARHGDIB | S44 | ochoa | Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}. |
| P54132 | BLM | S422 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P78347 | GTF2I | S146 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P78371 | CCT2 | S60 | ochoa | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q00653 | NFKB2 | S108 | psp | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q01804 | OTUD4 | S893 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q05397 | PTK2 | S850 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q06830 | PRDX1 | S30 | ochoa | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}. |
| Q08050 | FOXM1 | S739 | psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q08357 | SLC20A2 | S259 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q09666 | AHNAK | S470 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T590 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S613 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T718 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S793 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1042 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1170 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1298 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1344 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T1472 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1802 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2138 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2600 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2984 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3112 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3240 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T3625 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4360 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4614 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4803 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4870 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5125 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5279 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5318 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5393 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5582 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5620 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q0ZGT2 | NEXN | S168 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12874 | SF3A3 | S299 | ochoa | Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:8022796}. |
| Q12888 | TP53BP1 | S771 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12955 | ANK3 | S896 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13526 | PIN1 | S138 | psp | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q14789 | GOLGB1 | S671 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15459 | SF3A1 | Y410 | ochoa | Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006}. |
| Q2KHR3 | QSER1 | S920 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q3MJ13 | WDR72 | S970 | ochoa | WD repeat-containing protein 72 | Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. {ECO:0000250|UniProtKB:D3YYM4, ECO:0000269|PubMed:19853237, ECO:0000269|PubMed:25008349}. |
| Q5SW79 | CEP170 | S1362 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T1M5 | FKBP15 | S1024 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5UIP0 | RIF1 | S790 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q68CZ2 | TNS3 | S352 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q69YH5 | CDCA2 | S407 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6IQ23 | PLEKHA7 | S608 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q7Z417 | NUFIP2 | S134 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z422 | SZRD1 | S51 | ochoa | SUZ RNA-binding domain-containing (SUZ domain-containing protein 1) (Putative MAPK-activating protein PM18/PM20/PM22) | None |
| Q8IVF2 | AHNAK2 | S753 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S765 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S820 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S1198 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2179 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4046 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4324 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4425 | ochoa | Protein AHNAK2 | None |
| Q8IVH8 | MAP4K3 | S507 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9275185}. |
| Q8IWU2 | LMTK2 | S617 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IWU2 | LMTK2 | S1246 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IWZ3 | ANKHD1 | S887 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IYB7 | DIS3L2 | S643 | ochoa | DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}. |
| Q8N3Z6 | ZCCHC7 | S122 | ochoa | Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7) | None |
| Q8NCE2 | MTMR14 | S576 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q8ND24 | RNF214 | S123 | ochoa | RING finger protein 214 | None |
| Q8NDF8 | TENT4B | S488 | ochoa | Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}. |
| Q8NI08 | NCOA7 | S609 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TCN5 | ZNF507 | S427 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TEQ0 | SNX29 | S646 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8WUY3 | PRUNE2 | S1744 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q92545 | TMEM131 | S1649 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q96QT4 | TRPM7 | S1301 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q99497 | PARK7 | S57 | ochoa | Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) | Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:12796482, PubMed:17015834, PubMed:18711745, PubMed:19229105, PubMed:20304780, PubMed:25416785, PubMed:26995087, PubMed:28993701). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:14749723, PubMed:15502874, PubMed:17015834, PubMed:18711745, PubMed:21097510). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). But this function is rebuted by other works (PubMed:27903648, PubMed:31653696). As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:26995087, PubMed:28013050). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin (PubMed:30150385). Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels (PubMed:30150385, PubMed:30894531). Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093, PubMed:28993701, PubMed:31653696). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:16632486, PubMed:19229105). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). {ECO:0000250|UniProtKB:Q99LX0, ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12612053, ECO:0000269|PubMed:12855764, ECO:0000269|PubMed:12939276, ECO:0000269|PubMed:14749723, ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:15502874, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:17015834, ECO:0000269|PubMed:18626009, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20186336, ECO:0000269|PubMed:20304780, ECO:0000269|PubMed:21097510, ECO:0000269|PubMed:22523093, ECO:0000269|PubMed:23792957, ECO:0000269|PubMed:23847046, ECO:0000269|PubMed:25416785, ECO:0000269|PubMed:26995087, ECO:0000269|PubMed:28013050, ECO:0000269|PubMed:28596309, ECO:0000269|PubMed:28993701, ECO:0000269|PubMed:30150385, ECO:0000269|PubMed:30894531, ECO:0000269|PubMed:9070310}. |
| Q99623 | PHB2 | S176 | psp | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}. |
| Q9BZC7 | ABCA2 | S1327 | ochoa | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}. |
| Q9H2J7 | SLC6A15 | S675 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9H9E3 | COG4 | S523 | ochoa | Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) | Required for normal Golgi function (PubMed:19536132, PubMed:30290151). Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132). {ECO:0000269|PubMed:19536132, ECO:0000269|PubMed:30290151}. |
| Q9HCE3 | ZNF532 | S252 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
| Q9HCK1 | ZDBF2 | S631 | ochoa | DBF4-type zinc finger-containing protein 2 | None |
| Q9NQG5 | RPRD1B | S212 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}. |
| Q9NSI8 | SAMSN1 | S183 | ochoa | SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) | Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). {ECO:0000250, ECO:0000269|PubMed:15381729}. |
| Q9NVP2 | ASF1B | S169 | ochoa | Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II) | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:20953179, PubMed:21454524, PubMed:26527279). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Required for gonad development (PubMed:12842904). {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:26527279}. |
| Q9NWV8 | BABAM1 | S62 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
| Q9NYQ6 | CELSR1 | S2867 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9UET6 | FTSJ1 | S217 | ochoa | tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1) | Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). Requisite for faithful cytoplasmic translation (PubMed:32393790). Requires THADA for methylation of the nucleotide at position 32 of the anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293). Requires WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Promotes translation efficiency of the UUU codon (PubMed:32558197). Plays a role in neurogenesis (PubMed:36720500). Required for expression of genes involved in neurogenesis, mitochondrial translation and energy generation, and lipid biosynthesis (PubMed:33771871, PubMed:36720500). Requisite for RNA-mediated gene silencing (PubMed:36720500). May modify position 32 in tRNA(Arg(ACG)), tRNA(Arg(CCG)), tRNA(Arg(UCG)), tRNA(Cys(GCA)), tRNA(Cys(ACA)), tRNA(Gln(CUG)), tRNA(Gln(UUG)), tRNA(Gly(CCC)), tRNA(Leu(CAG))/tRNA(Leu(CAA)), tRNA(Leu(A/IAG)), tRNA(Leu(UAG)), tRNA(Phe(GAA)), tRNA(Pro(AGG))/tRNA(Pro(CGG))/tRNA(Pro(UGG)) and tRNA(Trp(CCA)), and position 34 in tRNA(Phe(GAA)), tRNA(Leu(CAA)), tRNA(Sec(UCA)), and tRNA(Trp(CCA)) (PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). {ECO:0000269|PubMed:25404562, ECO:0000269|PubMed:26310293, ECO:0000269|PubMed:32198346, ECO:0000269|PubMed:32393790, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871, ECO:0000269|PubMed:36720500}. |
| Q9UJF2 | RASAL2 | S803 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UK61 | TASOR | S788 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKL3 | CASP8AP2 | S815 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9Y2H2 | INPP5F | S830 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| Q9Y4G2 | PLEKHM1 | S305 | ochoa | Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162) | Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). {ECO:0000250|UniProtKB:Q5PQS0, ECO:0000250|UniProtKB:Q7TSI1, ECO:0000269|PubMed:12820725, ECO:0000269|PubMed:20943950, ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:28325809}.; FUNCTION: (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7. {ECO:0000269|PubMed:25500191}. |
| Q9Y5T5 | USP16 | S386 | psp | Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability. {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:17914355, ECO:0000269|PubMed:32129764}. |
| P30048 | PRDX3 | S86 | Sugiyama | Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:17707404, PubMed:29438714, PubMed:33889951, PubMed:7733872). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). Required for the maintenance of physical strength (By similarity). {ECO:0000250|UniProtKB:P20108, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:17707404, ECO:0000269|PubMed:29438714, ECO:0000269|PubMed:33889951, ECO:0000269|PubMed:7733872}. |
| P30044 | PRDX5 | S168 | Sugiyama | Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}. |
| Q15084 | PDIA6 | S88 | Sugiyama | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| O43615 | TIMM44 | S193 | Sugiyama | Mitochondrial import inner membrane translocase subunit TIM44 | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250|UniProtKB:O35857, ECO:0000250|UniProtKB:Q01852}. |
| O95365 | ZBTB7A | Y352 | Sugiyama | Zinc finger and BTB domain-containing protein 7A (Factor binding IST protein 1) (FBI-1) (Factor that binds to inducer of short transcripts protein 1) (HIV-1 1st-binding protein 1) (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) (Pokemon 1) (TTF-I-interacting peptide 21) (TIP21) (Zinc finger protein 857A) | Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149). {ECO:0000250|UniProtKB:O88939, ECO:0000250|UniProtKB:Q9QZ48, ECO:0000269|PubMed:12004059, ECO:0000269|PubMed:14701838, ECO:0000269|PubMed:17595526, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:24514149, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:26455326, ECO:0000269|PubMed:26816381}. |
| P62873 | GNB1 | S207 | Sugiyama | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:37991948, PubMed:38168118, PubMed:38552625). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625). {ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:35835867, ECO:0000269|PubMed:36087581, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:38168118, ECO:0000269|PubMed:38552625}. |
| Q9BX68 | HINT2 | S63 | Sugiyama | Adenosine 5'-monophosphoramidase HINT2 (EC 3.9.1.-) (HINT-3) (HIT-17kDa) (Histidine triad nucleotide-binding protein 2, mitochondrial) (HINT-2) (PKCI-1-related HIT protein) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367). May be involved in steroid biosynthesis (PubMed:18653718). May play a role in apoptosis (PubMed:16762638). {ECO:0000269|PubMed:16762638, ECO:0000269|PubMed:18653718, ECO:0000269|PubMed:31990367}. |
| P36894 | BMPR1A | S416 | Sugiyama | Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). {ECO:0000250|UniProtKB:P36895}. |
| Q86U42 | PABPN1 | S235 | Sugiyama | Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) | Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). {ECO:0000250|UniProtKB:Q28165, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:27871484}. |
| Q13162 | PRDX4 | S73 | Sugiyama | Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. {ECO:0000269|PubMed:9388242}. |
| P13073 | COX4I1 | S34 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| Q9BTD8 | RBM42 | S372 | Sugiyama | RNA-binding protein 42 (RNA-binding motif protein 42) | Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. {ECO:0000250}. |
| Q15349 | RPS6KA2 | S44 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| P62879 | GNB2 | S207 | Sugiyama | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Q9Y4K4 | MAP4K5 | S60 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 7.762437e-07 | 6.110 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 3.237687e-06 | 5.490 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 1.406067e-05 | 4.852 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 1.406067e-05 | 4.852 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 8.328657e-05 | 4.079 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 9.178226e-05 | 4.037 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 7.314261e-05 | 4.136 |
| R-HSA-391251 | Protein folding | 1.273642e-04 | 3.895 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.422041e-04 | 3.847 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.851362e-04 | 3.733 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.485836e-04 | 3.605 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.694845e-03 | 2.771 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.385477e-03 | 2.622 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 9.626734e-04 | 3.017 |
| R-HSA-199920 | CREB phosphorylation | 2.134635e-03 | 2.671 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.852867e-03 | 2.732 |
| R-HSA-198753 | ERK/MAPK targets | 1.026553e-03 | 2.989 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.694845e-03 | 2.771 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 7.222527e-04 | 3.141 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.385477e-03 | 2.622 |
| R-HSA-450294 | MAP kinase activation | 1.865662e-03 | 2.729 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.543277e-03 | 2.812 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 4.826660e-04 | 3.316 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.156031e-03 | 2.666 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.421949e-03 | 2.847 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.421949e-03 | 2.847 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.421949e-03 | 2.847 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 1.143421e-03 | 2.942 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.234252e-03 | 2.651 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.314523e-03 | 2.636 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.314523e-03 | 2.636 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.933351e-03 | 2.714 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 1.303943e-03 | 2.885 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.794571e-03 | 2.746 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 1.420704e-03 | 2.847 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.494550e-03 | 2.825 |
| R-HSA-2262752 | Cellular responses to stress | 1.855368e-03 | 2.732 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.567945e-03 | 2.590 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.656726e-03 | 2.576 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.840941e-03 | 2.547 |
| R-HSA-448424 | Interleukin-17 signaling | 2.894835e-03 | 2.538 |
| R-HSA-9930044 | Nuclear RNA decay | 3.230069e-03 | 2.491 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.004041e-03 | 2.522 |
| R-HSA-449147 | Signaling by Interleukins | 3.306525e-03 | 2.481 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.341742e-03 | 2.476 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.341742e-03 | 2.476 |
| R-HSA-390522 | Striated Muscle Contraction | 3.466264e-03 | 2.460 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.572494e-03 | 2.447 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 3.671093e-03 | 2.435 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 3.671093e-03 | 2.435 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 3.740023e-03 | 2.427 |
| R-HSA-448706 | Interleukin-1 processing | 3.740023e-03 | 2.427 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.237238e-03 | 2.373 |
| R-HSA-9646399 | Aggrephagy | 5.415560e-03 | 2.266 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.785540e-03 | 2.238 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 6.521280e-03 | 2.186 |
| R-HSA-381070 | IRE1alpha activates chaperones | 7.145324e-03 | 2.146 |
| R-HSA-75153 | Apoptotic execution phase | 7.911128e-03 | 2.102 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.350287e-03 | 2.078 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 8.729180e-03 | 2.059 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 9.063559e-03 | 2.043 |
| R-HSA-418885 | DCC mediated attractive signaling | 9.063559e-03 | 2.043 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 9.063559e-03 | 2.043 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 9.156116e-03 | 2.038 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 9.156116e-03 | 2.038 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 1.302755e-02 | 1.885 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 1.096568e-02 | 1.960 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 1.302755e-02 | 1.885 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.302755e-02 | 1.885 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 1.096568e-02 | 1.960 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.300993e-02 | 1.886 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 1.411680e-02 | 1.850 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.411680e-02 | 1.850 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.479445e-02 | 1.830 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.479445e-02 | 1.830 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.479445e-02 | 1.830 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.479445e-02 | 1.830 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.479445e-02 | 1.830 |
| R-HSA-373753 | Nephrin family interactions | 1.524411e-02 | 1.817 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 1.524411e-02 | 1.817 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 1.582197e-02 | 1.801 |
| R-HSA-202040 | G-protein activation | 1.640885e-02 | 1.785 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 1.640885e-02 | 1.785 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.642217e-02 | 1.785 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.703502e-02 | 1.769 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 2.143008e-02 | 1.669 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 2.012162e-02 | 1.696 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.143008e-02 | 1.669 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 2.143008e-02 | 1.669 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.827921e-02 | 1.738 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.761041e-02 | 1.754 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 2.143008e-02 | 1.669 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.096840e-02 | 1.678 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 2.211007e-02 | 1.655 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 2.211007e-02 | 1.655 |
| R-HSA-168315 | Inhibition of Host mRNA Processing and RNA Silencing | 2.211007e-02 | 1.655 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.239559e-02 | 1.650 |
| R-HSA-1296059 | G protein gated Potassium channels | 2.277300e-02 | 1.643 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 2.277300e-02 | 1.643 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 2.277300e-02 | 1.643 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.327102e-02 | 1.633 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.386324e-02 | 1.622 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 2.414981e-02 | 1.617 |
| R-HSA-9658195 | Leishmania infection | 2.571816e-02 | 1.590 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.571816e-02 | 1.590 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 2.700281e-02 | 1.569 |
| R-HSA-622312 | Inflammasomes | 2.700281e-02 | 1.569 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.847789e-02 | 1.545 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.468932e-02 | 1.460 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.468932e-02 | 1.460 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.309087e-02 | 1.480 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.940140e-02 | 1.532 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 3.309087e-02 | 1.480 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 2.998462e-02 | 1.523 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 3.024338e-02 | 1.519 |
| R-HSA-9663891 | Selective autophagy | 3.649019e-02 | 1.438 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 3.631728e-02 | 1.440 |
| R-HSA-1632852 | Macroautophagy | 3.109110e-02 | 1.507 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.631728e-02 | 1.440 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.857209e-02 | 1.544 |
| R-HSA-420092 | Glucagon-type ligand receptors | 2.847789e-02 | 1.545 |
| R-HSA-166520 | Signaling by NTRKs | 3.623489e-02 | 1.441 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.374404e-02 | 1.472 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.987725e-02 | 1.525 |
| R-HSA-8875513 | MET interacts with TNS proteins | 3.658009e-02 | 1.437 |
| R-HSA-392518 | Signal amplification | 3.797425e-02 | 1.421 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.828330e-02 | 1.417 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.965970e-02 | 1.402 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.968522e-02 | 1.401 |
| R-HSA-1500931 | Cell-Cell communication | 4.052201e-02 | 1.392 |
| R-HSA-9612973 | Autophagy | 4.184261e-02 | 1.378 |
| R-HSA-205025 | NADE modulates death signalling | 4.373528e-02 | 1.359 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 4.373528e-02 | 1.359 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.437588e-02 | 1.353 |
| R-HSA-8875878 | MET promotes cell motility | 4.488192e-02 | 1.348 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.646958e-02 | 1.333 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.849670e-02 | 1.314 |
| R-HSA-5260271 | Diseases of Immune System | 4.849670e-02 | 1.314 |
| R-HSA-9614085 | FOXO-mediated transcription | 4.970035e-02 | 1.304 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.034263e-02 | 1.298 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 5.083776e-02 | 1.294 |
| R-HSA-8866376 | Reelin signalling pathway | 5.083776e-02 | 1.294 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.191377e-02 | 1.285 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 7.872833e-02 | 1.104 |
| R-HSA-444257 | RSK activation | 7.872833e-02 | 1.104 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.870196e-02 | 1.163 |
| R-HSA-5693538 | Homology Directed Repair | 7.656266e-02 | 1.116 |
| R-HSA-9634597 | GPER1 signaling | 6.597367e-02 | 1.181 |
| R-HSA-991365 | Activation of GABAB receptors | 5.410920e-02 | 1.267 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.797230e-02 | 1.237 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.410920e-02 | 1.267 |
| R-HSA-977444 | GABA B receptor activation | 5.410920e-02 | 1.267 |
| R-HSA-373752 | Netrin-1 signaling | 5.797230e-02 | 1.237 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 6.488615e-02 | 1.188 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 5.788792e-02 | 1.237 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 5.788792e-02 | 1.237 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 5.993891e-02 | 1.222 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.445200e-02 | 1.264 |
| R-HSA-164944 | Nef and signal transduction | 6.488615e-02 | 1.188 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 5.993891e-02 | 1.222 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 6.394004e-02 | 1.194 |
| R-HSA-2559583 | Cellular Senescence | 6.235518e-02 | 1.205 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.127923e-02 | 1.147 |
| R-HSA-373760 | L1CAM interactions | 7.389965e-02 | 1.131 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.192830e-02 | 1.208 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.192830e-02 | 1.208 |
| R-HSA-437239 | Recycling pathway of L1 | 6.394004e-02 | 1.194 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 5.797230e-02 | 1.237 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.002912e-02 | 1.222 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.002912e-02 | 1.222 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.378277e-02 | 1.132 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.063575e-02 | 1.093 |
| R-HSA-418597 | G alpha (z) signalling events | 8.078699e-02 | 1.093 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 8.557303e-02 | 1.068 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 8.557303e-02 | 1.068 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 8.557303e-02 | 1.068 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 8.967002e-02 | 1.047 |
| R-HSA-69481 | G2/M Checkpoints | 9.049599e-02 | 1.043 |
| R-HSA-977443 | GABA receptor activation | 9.193440e-02 | 1.037 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 9.194420e-02 | 1.036 |
| R-HSA-445717 | Aquaporin-mediated transport | 9.421548e-02 | 1.026 |
| R-HSA-1640170 | Cell Cycle | 9.509576e-02 | 1.022 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.613936e-02 | 1.017 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.190473e-01 | 0.924 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.255949e-01 | 0.901 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.385456e-01 | 0.858 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.513061e-01 | 0.820 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.638791e-01 | 0.785 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.700962e-01 | 0.769 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.700962e-01 | 0.769 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.700962e-01 | 0.769 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.700962e-01 | 0.769 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.823931e-01 | 0.739 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.823931e-01 | 0.739 |
| R-HSA-3928664 | Ephrin signaling | 1.576159e-01 | 0.802 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.255949e-01 | 0.901 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.190473e-01 | 0.924 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.582673e-01 | 0.801 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.576159e-01 | 0.802 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.385456e-01 | 0.858 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.884736e-01 | 0.725 |
| R-HSA-8949664 | Processing of SMDT1 | 1.190473e-01 | 0.924 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.449495e-01 | 0.839 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.058060e-01 | 0.975 |
| R-HSA-202670 | ERKs are inactivated | 1.058060e-01 | 0.975 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.190473e-01 | 0.924 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.190473e-01 | 0.924 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.320942e-01 | 0.879 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.766721e-01 | 0.753 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.638791e-01 | 0.785 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 1.700962e-01 | 0.769 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.255949e-01 | 0.901 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 9.651289e-02 | 1.015 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 1.823931e-01 | 0.739 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.884736e-01 | 0.725 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.352092e-01 | 0.869 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.900170e-01 | 0.721 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.847620e-01 | 0.733 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.608740e-01 | 0.794 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 1.190473e-01 | 0.924 |
| R-HSA-2485179 | Activation of the phototransduction cascade | 1.385456e-01 | 0.858 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.823931e-01 | 0.739 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.203074e-01 | 0.920 |
| R-HSA-422475 | Axon guidance | 1.308815e-01 | 0.883 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.638791e-01 | 0.785 |
| R-HSA-9675108 | Nervous system development | 1.644098e-01 | 0.784 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 1.255949e-01 | 0.901 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.082324e-01 | 0.966 |
| R-HSA-4086398 | Ca2+ pathway | 1.227615e-01 | 0.911 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.320942e-01 | 0.879 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.261092e-01 | 0.899 |
| R-HSA-1296071 | Potassium Channels | 1.900170e-01 | 0.721 |
| R-HSA-157579 | Telomere Maintenance | 1.927027e-01 | 0.715 |
| R-HSA-210990 | PECAM1 interactions | 9.911149e-02 | 1.004 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.255949e-01 | 0.901 |
| R-HSA-1237112 | Methionine salvage pathway | 1.638791e-01 | 0.785 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.190473e-01 | 0.924 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 1.731491e-01 | 0.762 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 1.731491e-01 | 0.762 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.385456e-01 | 0.858 |
| R-HSA-6806834 | Signaling by MET | 1.402655e-01 | 0.853 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.582673e-01 | 0.801 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.124511e-01 | 0.949 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.058586e-01 | 0.975 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.255949e-01 | 0.901 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.320942e-01 | 0.879 |
| R-HSA-8939211 | ESR-mediated signaling | 1.263887e-01 | 0.898 |
| R-HSA-8983711 | OAS antiviral response | 1.124511e-01 | 0.949 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.927027e-01 | 0.715 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 1.687407e-01 | 0.773 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.154374e-01 | 0.938 |
| R-HSA-109581 | Apoptosis | 1.516405e-01 | 0.819 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.178660e-01 | 0.929 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.034995e-01 | 0.985 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.301958e-01 | 0.885 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.608740e-01 | 0.794 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 1.945093e-01 | 0.711 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 1.945093e-01 | 0.711 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.945093e-01 | 0.711 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.945093e-01 | 0.711 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.951928e-01 | 0.710 |
| R-HSA-422356 | Regulation of insulin secretion | 1.953935e-01 | 0.709 |
| R-HSA-69275 | G2/M Transition | 1.973560e-01 | 0.705 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.980891e-01 | 0.703 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.998085e-01 | 0.699 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.005005e-01 | 0.698 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.005005e-01 | 0.698 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.005005e-01 | 0.698 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.011526e-01 | 0.696 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.034940e-01 | 0.691 |
| R-HSA-5617833 | Cilium Assembly | 2.049668e-01 | 0.688 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.062029e-01 | 0.686 |
| R-HSA-1483255 | PI Metabolism | 2.062029e-01 | 0.686 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.064474e-01 | 0.685 |
| R-HSA-9620244 | Long-term potentiation | 2.064474e-01 | 0.685 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.064474e-01 | 0.685 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.105577e-01 | 0.677 |
| R-HSA-111885 | Opioid Signalling | 2.116323e-01 | 0.674 |
| R-HSA-8874081 | MET activates PTK2 signaling | 2.123505e-01 | 0.673 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.123505e-01 | 0.673 |
| R-HSA-3295583 | TRP channels | 2.123505e-01 | 0.673 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.126452e-01 | 0.672 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.182101e-01 | 0.661 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.182101e-01 | 0.661 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.182101e-01 | 0.661 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.182101e-01 | 0.661 |
| R-HSA-201451 | Signaling by BMP | 2.182101e-01 | 0.661 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.182101e-01 | 0.661 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.182101e-01 | 0.661 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.182101e-01 | 0.661 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.182101e-01 | 0.661 |
| R-HSA-418346 | Platelet homeostasis | 2.198028e-01 | 0.658 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.198028e-01 | 0.658 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.240264e-01 | 0.650 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.240264e-01 | 0.650 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.252651e-01 | 0.647 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.281845e-01 | 0.642 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.297998e-01 | 0.639 |
| R-HSA-72172 | mRNA Splicing | 2.340682e-01 | 0.631 |
| R-HSA-2424491 | DAP12 signaling | 2.355306e-01 | 0.628 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.355306e-01 | 0.628 |
| R-HSA-5357801 | Programmed Cell Death | 2.360356e-01 | 0.627 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 2.412191e-01 | 0.618 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.412191e-01 | 0.618 |
| R-HSA-397014 | Muscle contraction | 2.498875e-01 | 0.602 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.499527e-01 | 0.602 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.524706e-01 | 0.598 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.524706e-01 | 0.598 |
| R-HSA-354192 | Integrin signaling | 2.524706e-01 | 0.598 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.524706e-01 | 0.598 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.524706e-01 | 0.598 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.534210e-01 | 0.596 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.580341e-01 | 0.588 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.580341e-01 | 0.588 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 2.580341e-01 | 0.588 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.582062e-01 | 0.588 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.609586e-01 | 0.583 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.635565e-01 | 0.579 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.635565e-01 | 0.579 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.635565e-01 | 0.579 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.635565e-01 | 0.579 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.635565e-01 | 0.579 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.635565e-01 | 0.579 |
| R-HSA-73886 | Chromosome Maintenance | 2.664643e-01 | 0.574 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.690382e-01 | 0.570 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.719702e-01 | 0.565 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.744794e-01 | 0.561 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.747229e-01 | 0.561 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.798804e-01 | 0.553 |
| R-HSA-194138 | Signaling by VEGF | 2.802269e-01 | 0.552 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.852416e-01 | 0.545 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.852416e-01 | 0.545 |
| R-HSA-114608 | Platelet degranulation | 2.857281e-01 | 0.544 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.905632e-01 | 0.537 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.905632e-01 | 0.537 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 2.905632e-01 | 0.537 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.929243e-01 | 0.533 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.958455e-01 | 0.529 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.958455e-01 | 0.529 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.958455e-01 | 0.529 |
| R-HSA-167169 | HIV Transcription Elongation | 2.958455e-01 | 0.529 |
| R-HSA-112316 | Neuronal System | 3.009238e-01 | 0.522 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.010887e-01 | 0.521 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.010887e-01 | 0.521 |
| R-HSA-9607240 | FLT3 Signaling | 3.010887e-01 | 0.521 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.049451e-01 | 0.516 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.062933e-01 | 0.514 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.062933e-01 | 0.514 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 3.062933e-01 | 0.514 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.062933e-01 | 0.514 |
| R-HSA-8953854 | Metabolism of RNA | 3.071010e-01 | 0.513 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.114594e-01 | 0.507 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 3.114594e-01 | 0.507 |
| R-HSA-73894 | DNA Repair | 3.146768e-01 | 0.502 |
| R-HSA-163685 | Integration of energy metabolism | 3.158878e-01 | 0.500 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.158878e-01 | 0.500 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.165874e-01 | 0.500 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.197203e-01 | 0.495 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.216775e-01 | 0.493 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.216775e-01 | 0.493 |
| R-HSA-69236 | G1 Phase | 3.216775e-01 | 0.493 |
| R-HSA-2172127 | DAP12 interactions | 3.216775e-01 | 0.493 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.267300e-01 | 0.486 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.267300e-01 | 0.486 |
| R-HSA-9664417 | Leishmania phagocytosis | 3.267928e-01 | 0.486 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.267928e-01 | 0.486 |
| R-HSA-9664407 | Parasite infection | 3.267928e-01 | 0.486 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.317452e-01 | 0.479 |
| R-HSA-9675135 | Diseases of DNA repair | 3.317452e-01 | 0.479 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 3.317452e-01 | 0.479 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.367233e-01 | 0.473 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.367233e-01 | 0.473 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.388094e-01 | 0.470 |
| R-HSA-389356 | Co-stimulation by CD28 | 3.416647e-01 | 0.466 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.416647e-01 | 0.466 |
| R-HSA-9766229 | Degradation of CDH1 | 3.465695e-01 | 0.460 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.514381e-01 | 0.454 |
| R-HSA-392499 | Metabolism of proteins | 3.517488e-01 | 0.454 |
| R-HSA-416476 | G alpha (q) signalling events | 3.550624e-01 | 0.450 |
| R-HSA-9864848 | Complex IV assembly | 3.562707e-01 | 0.448 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.562707e-01 | 0.448 |
| R-HSA-912446 | Meiotic recombination | 3.562707e-01 | 0.448 |
| R-HSA-2514856 | The phototransduction cascade | 3.562707e-01 | 0.448 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.565305e-01 | 0.448 |
| R-HSA-72187 | mRNA 3'-end processing | 3.610677e-01 | 0.442 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.610677e-01 | 0.442 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.610677e-01 | 0.442 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.610677e-01 | 0.442 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.618904e-01 | 0.441 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.658291e-01 | 0.437 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 3.658291e-01 | 0.437 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.658291e-01 | 0.437 |
| R-HSA-73887 | Death Receptor Signaling | 3.672340e-01 | 0.435 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.672340e-01 | 0.435 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.700092e-01 | 0.432 |
| R-HSA-72649 | Translation initiation complex formation | 3.705554e-01 | 0.431 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.705554e-01 | 0.431 |
| R-HSA-156588 | Glucuronidation | 3.705554e-01 | 0.431 |
| R-HSA-9711097 | Cellular response to starvation | 3.778695e-01 | 0.423 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.778695e-01 | 0.423 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.799034e-01 | 0.420 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.799034e-01 | 0.420 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.831601e-01 | 0.417 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.831601e-01 | 0.417 |
| R-HSA-446728 | Cell junction organization | 3.833796e-01 | 0.416 |
| R-HSA-5621480 | Dectin-2 family | 3.845257e-01 | 0.415 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.845257e-01 | 0.415 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.891137e-01 | 0.410 |
| R-HSA-180786 | Extension of Telomeres | 3.936679e-01 | 0.405 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 3.936679e-01 | 0.405 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.981884e-01 | 0.400 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.026755e-01 | 0.395 |
| R-HSA-1268020 | Mitochondrial protein import | 4.071293e-01 | 0.390 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.071293e-01 | 0.390 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.071293e-01 | 0.390 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.071293e-01 | 0.390 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.115503e-01 | 0.386 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.115503e-01 | 0.386 |
| R-HSA-373755 | Semaphorin interactions | 4.115503e-01 | 0.386 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.115503e-01 | 0.386 |
| R-HSA-418555 | G alpha (s) signalling events | 4.144862e-01 | 0.382 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.170622e-01 | 0.380 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.196325e-01 | 0.377 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.196325e-01 | 0.377 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.221972e-01 | 0.374 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.246179e-01 | 0.372 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 4.246179e-01 | 0.372 |
| R-HSA-168249 | Innate Immune System | 4.247538e-01 | 0.372 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.247562e-01 | 0.372 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.289095e-01 | 0.368 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 4.289095e-01 | 0.368 |
| R-HSA-611105 | Respiratory electron transport | 4.323981e-01 | 0.364 |
| R-HSA-167172 | Transcription of the HIV genome | 4.331694e-01 | 0.363 |
| R-HSA-168255 | Influenza Infection | 4.349336e-01 | 0.362 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.415948e-01 | 0.355 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.415948e-01 | 0.355 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.498960e-01 | 0.347 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.498960e-01 | 0.347 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.540006e-01 | 0.343 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.540006e-01 | 0.343 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.580749e-01 | 0.339 |
| R-HSA-380287 | Centrosome maturation | 4.621189e-01 | 0.335 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.621189e-01 | 0.335 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 4.621189e-01 | 0.335 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.662486e-01 | 0.331 |
| R-HSA-382551 | Transport of small molecules | 4.727007e-01 | 0.325 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.740725e-01 | 0.324 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.770810e-01 | 0.321 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.867226e-01 | 0.313 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.934123e-01 | 0.307 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.934123e-01 | 0.307 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.938818e-01 | 0.306 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.971948e-01 | 0.303 |
| R-HSA-1500620 | Meiosis | 5.009493e-01 | 0.300 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.009493e-01 | 0.300 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 5.083750e-01 | 0.294 |
| R-HSA-162582 | Signal Transduction | 5.108767e-01 | 0.292 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.156912e-01 | 0.288 |
| R-HSA-156902 | Peptide chain elongation | 5.156912e-01 | 0.288 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.156912e-01 | 0.288 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.174662e-01 | 0.286 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.195916e-01 | 0.284 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.228994e-01 | 0.282 |
| R-HSA-202424 | Downstream TCR signaling | 5.228994e-01 | 0.282 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.264635e-01 | 0.279 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.300012e-01 | 0.276 |
| R-HSA-418990 | Adherens junctions interactions | 5.309908e-01 | 0.275 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.335126e-01 | 0.273 |
| R-HSA-2029481 | FCGR activation | 5.369981e-01 | 0.270 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.369981e-01 | 0.270 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.404577e-01 | 0.267 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.404577e-01 | 0.267 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.438917e-01 | 0.264 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.473003e-01 | 0.262 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.473003e-01 | 0.262 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 5.506836e-01 | 0.259 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.506836e-01 | 0.259 |
| R-HSA-162906 | HIV Infection | 5.510470e-01 | 0.259 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.540418e-01 | 0.256 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.573751e-01 | 0.254 |
| R-HSA-109582 | Hemostasis | 5.582676e-01 | 0.253 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.639678e-01 | 0.249 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.662298e-01 | 0.247 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.672275e-01 | 0.246 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.704631e-01 | 0.244 |
| R-HSA-192823 | Viral mRNA Translation | 5.736747e-01 | 0.241 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.768624e-01 | 0.239 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.893788e-01 | 0.230 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.924501e-01 | 0.227 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.924501e-01 | 0.227 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.924501e-01 | 0.227 |
| R-HSA-4839726 | Chromatin organization | 5.975216e-01 | 0.224 |
| R-HSA-202403 | TCR signaling | 5.985245e-01 | 0.223 |
| R-HSA-421270 | Cell-cell junction organization | 6.015652e-01 | 0.221 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.045091e-01 | 0.219 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.045091e-01 | 0.219 |
| R-HSA-597592 | Post-translational protein modification | 6.055218e-01 | 0.218 |
| R-HSA-5688426 | Deubiquitination | 6.095614e-01 | 0.215 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.133206e-01 | 0.212 |
| R-HSA-168256 | Immune System | 6.150523e-01 | 0.211 |
| R-HSA-1266738 | Developmental Biology | 6.150898e-01 | 0.211 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.219373e-01 | 0.206 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.219373e-01 | 0.206 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.247670e-01 | 0.204 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.251904e-01 | 0.204 |
| R-HSA-74160 | Gene expression (Transcription) | 6.322576e-01 | 0.199 |
| R-HSA-212436 | Generic Transcription Pathway | 6.327563e-01 | 0.199 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 6.413095e-01 | 0.193 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.413095e-01 | 0.193 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 6.444685e-01 | 0.191 |
| R-HSA-69206 | G1/S Transition | 6.493075e-01 | 0.188 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 6.519340e-01 | 0.186 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.603789e-01 | 0.180 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.622463e-01 | 0.179 |
| R-HSA-1474165 | Reproduction | 6.647767e-01 | 0.177 |
| R-HSA-9717189 | Sensory perception of taste | 6.672882e-01 | 0.176 |
| R-HSA-9843745 | Adipogenesis | 6.672882e-01 | 0.176 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.819706e-01 | 0.166 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.829123e-01 | 0.166 |
| R-HSA-1483257 | Phospholipid metabolism | 6.829123e-01 | 0.166 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.867204e-01 | 0.163 |
| R-HSA-195721 | Signaling by WNT | 6.879373e-01 | 0.162 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.937136e-01 | 0.159 |
| R-HSA-6798695 | Neutrophil degranulation | 6.947156e-01 | 0.158 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.982895e-01 | 0.156 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.027976e-01 | 0.153 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.072389e-01 | 0.150 |
| R-HSA-2187338 | Visual phototransduction | 7.094348e-01 | 0.149 |
| R-HSA-69242 | S Phase | 7.116144e-01 | 0.148 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.201717e-01 | 0.143 |
| R-HSA-9609507 | Protein localization | 7.222714e-01 | 0.141 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.264240e-01 | 0.139 |
| R-HSA-162587 | HIV Life Cycle | 7.305151e-01 | 0.136 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.443617e-01 | 0.128 |
| R-HSA-5619102 | SLC transporter disorders | 7.500778e-01 | 0.125 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.530426e-01 | 0.123 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.544086e-01 | 0.122 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.575025e-01 | 0.121 |
| R-HSA-72306 | tRNA processing | 7.575025e-01 | 0.121 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.629271e-01 | 0.118 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.882968e-01 | 0.103 |
| R-HSA-983712 | Ion channel transport | 7.898890e-01 | 0.102 |
| R-HSA-68877 | Mitotic Prometaphase | 7.961399e-01 | 0.099 |
| R-HSA-9609690 | HCMV Early Events | 8.007068e-01 | 0.097 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.062041e-01 | 0.094 |
| R-HSA-913531 | Interferon Signaling | 8.062041e-01 | 0.094 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.066384e-01 | 0.093 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.109719e-01 | 0.091 |
| R-HSA-69278 | Cell Cycle, Mitotic | 8.170698e-01 | 0.088 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.212007e-01 | 0.086 |
| R-HSA-418594 | G alpha (i) signalling events | 8.312729e-01 | 0.080 |
| R-HSA-8951664 | Neddylation | 8.362662e-01 | 0.078 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.447132e-01 | 0.073 |
| R-HSA-72312 | rRNA processing | 8.493446e-01 | 0.071 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.549415e-01 | 0.068 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.571222e-01 | 0.067 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.655242e-01 | 0.063 |
| R-HSA-9609646 | HCMV Infection | 8.685471e-01 | 0.061 |
| R-HSA-1643685 | Disease | 8.748392e-01 | 0.058 |
| R-HSA-199991 | Membrane Trafficking | 8.794332e-01 | 0.056 |
| R-HSA-5663205 | Infectious disease | 9.016629e-01 | 0.045 |
| R-HSA-1280218 | Adaptive Immune System | 9.053242e-01 | 0.043 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.245029e-01 | 0.034 |
| R-HSA-9679506 | SARS-CoV Infections | 9.311006e-01 | 0.031 |
| R-HSA-9824446 | Viral Infection Pathways | 9.350476e-01 | 0.029 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.380727e-01 | 0.028 |
| R-HSA-388396 | GPCR downstream signalling | 9.391206e-01 | 0.027 |
| R-HSA-500792 | GPCR ligand binding | 9.443838e-01 | 0.025 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.497582e-01 | 0.022 |
| R-HSA-68886 | M Phase | 9.522313e-01 | 0.021 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.537671e-01 | 0.021 |
| R-HSA-372790 | Signaling by GPCR | 9.620996e-01 | 0.017 |
| R-HSA-72766 | Translation | 9.666654e-01 | 0.015 |
| R-HSA-211859 | Biological oxidations | 9.838197e-01 | 0.007 |
| R-HSA-381753 | Olfactory Signaling Pathway | 9.988851e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999001e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999423e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999998e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
IKKE |
0.769 | 0.338 | 1 | 0.562 |
TGFBR2 |
0.765 | 0.318 | -2 | 0.516 |
TBK1 |
0.764 | 0.287 | 1 | 0.533 |
DSTYK |
0.761 | 0.248 | 2 | 0.784 |
NEK6 |
0.761 | 0.258 | -2 | 0.470 |
COT |
0.760 | 0.146 | 2 | 0.782 |
IKKB |
0.757 | 0.075 | -2 | 0.224 |
NEK7 |
0.756 | 0.222 | -3 | 0.846 |
ULK2 |
0.752 | 0.056 | 2 | 0.714 |
PLK1 |
0.750 | 0.339 | -2 | 0.534 |
IKKA |
0.748 | 0.059 | -2 | 0.232 |
GCN2 |
0.748 | 0.085 | 2 | 0.689 |
RAF1 |
0.748 | 0.160 | 1 | 0.473 |
KIS |
0.747 | 0.047 | 1 | 0.278 |
PDHK1 |
0.746 | 0.154 | 1 | 0.494 |
ACVR2A |
0.743 | 0.256 | -2 | 0.528 |
MTOR |
0.743 | 0.009 | 1 | 0.406 |
BMPR2 |
0.743 | 0.275 | -2 | 0.385 |
ULK1 |
0.742 | 0.025 | -3 | 0.832 |
MST4 |
0.741 | 0.055 | 2 | 0.808 |
ACVR2B |
0.740 | 0.223 | -2 | 0.504 |
CDC7 |
0.739 | -0.030 | 1 | 0.278 |
CHAK2 |
0.739 | 0.022 | -1 | 0.770 |
YSK4 |
0.738 | 0.184 | 1 | 0.474 |
PRPK |
0.738 | -0.069 | -1 | 0.819 |
NEK9 |
0.738 | 0.078 | 2 | 0.760 |
PDHK4 |
0.738 | 0.011 | 1 | 0.432 |
MOS |
0.736 | -0.015 | 1 | 0.297 |
BCKDK |
0.736 | 0.069 | -1 | 0.732 |
NLK |
0.735 | -0.041 | 1 | 0.356 |
MLK1 |
0.735 | 0.011 | 2 | 0.736 |
PLK4 |
0.735 | 0.184 | 2 | 0.547 |
CLK3 |
0.735 | 0.020 | 1 | 0.299 |
TLK2 |
0.734 | 0.163 | 1 | 0.382 |
BMPR1B |
0.734 | 0.051 | 1 | 0.251 |
GRK1 |
0.733 | 0.004 | -2 | 0.241 |
GRK7 |
0.733 | 0.102 | 1 | 0.293 |
TGFBR1 |
0.733 | 0.033 | -2 | 0.346 |
PIM3 |
0.733 | -0.051 | -3 | 0.775 |
PERK |
0.732 | 0.260 | -2 | 0.481 |
CAMK2G |
0.732 | -0.036 | 2 | 0.703 |
TTBK2 |
0.732 | 0.048 | 2 | 0.624 |
PLK3 |
0.732 | 0.171 | 2 | 0.653 |
ATR |
0.732 | -0.060 | 1 | 0.324 |
HRI |
0.732 | 0.261 | -2 | 0.491 |
ANKRD3 |
0.731 | 0.093 | 1 | 0.406 |
PKCD |
0.730 | 0.006 | 2 | 0.734 |
PRKD1 |
0.730 | -0.026 | -3 | 0.772 |
FAM20C |
0.730 | 0.063 | 2 | 0.582 |
ERK5 |
0.729 | -0.087 | 1 | 0.325 |
SRPK1 |
0.729 | 0.023 | -3 | 0.704 |
MARK4 |
0.729 | -0.038 | 4 | 0.866 |
ALK4 |
0.728 | 0.036 | -2 | 0.350 |
GRK4 |
0.728 | 0.031 | -2 | 0.364 |
PKN3 |
0.728 | -0.046 | -3 | 0.792 |
SRPK2 |
0.728 | 0.057 | -3 | 0.631 |
PAK6 |
0.728 | -0.008 | -2 | 0.191 |
HIPK4 |
0.727 | -0.043 | 1 | 0.305 |
AURC |
0.727 | -0.022 | -2 | 0.178 |
NEK2 |
0.727 | 0.039 | 2 | 0.745 |
CDK8 |
0.726 | -0.060 | 1 | 0.256 |
CAMK1B |
0.726 | -0.091 | -3 | 0.825 |
MLK3 |
0.726 | 0.002 | 2 | 0.687 |
WNK3 |
0.726 | -0.065 | 1 | 0.426 |
SRPK3 |
0.726 | 0.088 | -3 | 0.681 |
LATS1 |
0.725 | 0.120 | -3 | 0.800 |
TLK1 |
0.725 | 0.187 | -2 | 0.444 |
NIK |
0.725 | -0.071 | -3 | 0.839 |
PRKD2 |
0.725 | -0.021 | -3 | 0.721 |
MLK2 |
0.725 | -0.074 | 2 | 0.755 |
CDKL1 |
0.724 | -0.049 | -3 | 0.769 |
GRK5 |
0.724 | -0.098 | -3 | 0.816 |
CAMK2D |
0.724 | -0.041 | -3 | 0.800 |
CAMLCK |
0.724 | -0.071 | -2 | 0.275 |
WNK1 |
0.724 | -0.081 | -2 | 0.238 |
ALK2 |
0.723 | 0.044 | -2 | 0.364 |
AURB |
0.723 | -0.021 | -2 | 0.183 |
RSK3 |
0.723 | -0.029 | -3 | 0.726 |
PKN2 |
0.723 | -0.055 | -3 | 0.789 |
RIPK3 |
0.722 | -0.097 | 3 | 0.682 |
CDKL5 |
0.722 | -0.052 | -3 | 0.759 |
DNAPK |
0.722 | 0.049 | 1 | 0.435 |
ATM |
0.722 | -0.018 | 1 | 0.291 |
CDK1 |
0.722 | -0.010 | 1 | 0.209 |
BMPR1A |
0.721 | 0.030 | 1 | 0.241 |
PKG2 |
0.721 | -0.032 | -2 | 0.179 |
RSK2 |
0.721 | -0.036 | -3 | 0.730 |
CDK19 |
0.721 | -0.062 | 1 | 0.242 |
PKR |
0.720 | 0.012 | 1 | 0.370 |
AURA |
0.720 | -0.010 | -2 | 0.188 |
MLK4 |
0.720 | 0.010 | 2 | 0.650 |
NDR2 |
0.720 | -0.082 | -3 | 0.779 |
PKACG |
0.720 | -0.057 | -2 | 0.208 |
HUNK |
0.719 | -0.101 | 2 | 0.687 |
ICK |
0.719 | -0.061 | -3 | 0.799 |
JNK2 |
0.719 | -0.028 | 1 | 0.255 |
SKMLCK |
0.719 | -0.099 | -2 | 0.257 |
AMPKA1 |
0.719 | -0.075 | -3 | 0.796 |
NDR1 |
0.719 | -0.078 | -3 | 0.779 |
DAPK2 |
0.718 | -0.097 | -3 | 0.831 |
DLK |
0.718 | -0.082 | 1 | 0.379 |
PAK3 |
0.718 | -0.078 | -2 | 0.219 |
GRK6 |
0.718 | -0.059 | 1 | 0.334 |
MAPKAPK3 |
0.718 | -0.067 | -3 | 0.718 |
NUAK2 |
0.718 | -0.066 | -3 | 0.792 |
CHAK1 |
0.718 | -0.026 | 2 | 0.734 |
PKCA |
0.718 | -0.003 | 2 | 0.685 |
MASTL |
0.718 | -0.144 | -2 | 0.289 |
P90RSK |
0.718 | -0.044 | -3 | 0.733 |
JNK3 |
0.718 | -0.030 | 1 | 0.254 |
P70S6KB |
0.717 | -0.055 | -3 | 0.751 |
CDK3 |
0.717 | 0.012 | 1 | 0.186 |
LATS2 |
0.717 | -0.036 | -5 | 0.673 |
CDK5 |
0.717 | -0.030 | 1 | 0.239 |
TSSK1 |
0.717 | -0.051 | -3 | 0.812 |
PIM1 |
0.717 | -0.049 | -3 | 0.717 |
P38B |
0.717 | -0.046 | 1 | 0.256 |
NIM1 |
0.716 | -0.093 | 3 | 0.739 |
MEK1 |
0.716 | -0.031 | 2 | 0.750 |
PAK1 |
0.716 | -0.073 | -2 | 0.219 |
IRE1 |
0.715 | -0.097 | 1 | 0.333 |
TSSK2 |
0.715 | -0.091 | -5 | 0.733 |
MST2 |
0.715 | 0.192 | 1 | 0.471 |
MNK2 |
0.715 | -0.058 | -2 | 0.229 |
QSK |
0.715 | -0.035 | 4 | 0.846 |
ZAK |
0.715 | 0.007 | 1 | 0.422 |
TTBK1 |
0.715 | 0.016 | 2 | 0.550 |
MEKK1 |
0.715 | 0.036 | 1 | 0.418 |
IRE2 |
0.714 | -0.055 | 2 | 0.695 |
PHKG1 |
0.714 | -0.041 | -3 | 0.762 |
ERK1 |
0.714 | -0.056 | 1 | 0.262 |
MEKK2 |
0.714 | 0.080 | 2 | 0.726 |
CDK7 |
0.714 | -0.069 | 1 | 0.248 |
CDK2 |
0.714 | -0.015 | 1 | 0.248 |
SMG1 |
0.714 | -0.060 | 1 | 0.316 |
P38G |
0.713 | -0.043 | 1 | 0.196 |
CAMK2B |
0.713 | -0.035 | 2 | 0.674 |
PRKD3 |
0.713 | -0.039 | -3 | 0.702 |
PKACB |
0.713 | -0.034 | -2 | 0.196 |
AMPKA2 |
0.713 | -0.068 | -3 | 0.764 |
CLK1 |
0.712 | -0.019 | -3 | 0.704 |
VRK2 |
0.712 | -0.118 | 1 | 0.367 |
MAPKAPK2 |
0.712 | -0.056 | -3 | 0.672 |
TAO3 |
0.712 | 0.078 | 1 | 0.423 |
MINK |
0.711 | 0.215 | 1 | 0.524 |
DYRK2 |
0.711 | -0.081 | 1 | 0.261 |
CDK13 |
0.711 | -0.071 | 1 | 0.245 |
CLK4 |
0.711 | -0.035 | -3 | 0.716 |
BRAF |
0.711 | -0.016 | -4 | 0.821 |
PKCB |
0.711 | -0.044 | 2 | 0.686 |
PKCG |
0.711 | -0.039 | 2 | 0.678 |
MEKK3 |
0.711 | 0.030 | 1 | 0.414 |
MARK2 |
0.710 | -0.037 | 4 | 0.776 |
P38D |
0.710 | -0.040 | 1 | 0.206 |
P38A |
0.710 | -0.069 | 1 | 0.281 |
NEK5 |
0.710 | 0.029 | 1 | 0.380 |
PAK2 |
0.710 | -0.085 | -2 | 0.216 |
SGK3 |
0.710 | -0.041 | -3 | 0.712 |
QIK |
0.710 | -0.100 | -3 | 0.799 |
MST1 |
0.710 | 0.218 | 1 | 0.493 |
MARK3 |
0.709 | -0.040 | 4 | 0.806 |
TNIK |
0.709 | 0.175 | 3 | 0.832 |
SIK |
0.709 | -0.051 | -3 | 0.713 |
MELK |
0.709 | -0.102 | -3 | 0.753 |
HGK |
0.709 | 0.141 | 3 | 0.815 |
RIPK1 |
0.709 | -0.189 | 1 | 0.356 |
PAK5 |
0.709 | -0.039 | -2 | 0.176 |
CDK18 |
0.708 | -0.063 | 1 | 0.209 |
PKCH |
0.708 | -0.053 | 2 | 0.663 |
NUAK1 |
0.708 | -0.072 | -3 | 0.744 |
MST3 |
0.707 | 0.008 | 2 | 0.763 |
MSK2 |
0.706 | -0.075 | -3 | 0.687 |
NEK4 |
0.706 | 0.099 | 1 | 0.474 |
PKCZ |
0.706 | -0.087 | 2 | 0.717 |
NEK8 |
0.706 | 0.040 | 2 | 0.740 |
HIPK2 |
0.706 | -0.056 | 1 | 0.219 |
MARK1 |
0.705 | -0.050 | 4 | 0.828 |
PHKG2 |
0.705 | -0.029 | -3 | 0.756 |
CAMK4 |
0.705 | -0.140 | -3 | 0.767 |
CDK17 |
0.705 | -0.065 | 1 | 0.184 |
CDK12 |
0.705 | -0.070 | 1 | 0.244 |
LOK |
0.705 | 0.069 | -2 | 0.256 |
BRSK2 |
0.705 | -0.056 | -3 | 0.762 |
GCK |
0.705 | 0.187 | 1 | 0.492 |
PAK4 |
0.704 | -0.039 | -2 | 0.180 |
CAMKK1 |
0.704 | -0.053 | -2 | 0.233 |
TTK |
0.704 | 0.345 | -2 | 0.558 |
PKACA |
0.704 | -0.032 | -2 | 0.172 |
PINK1 |
0.704 | -0.115 | 1 | 0.309 |
GRK2 |
0.704 | -0.090 | -2 | 0.244 |
PLK2 |
0.704 | 0.097 | -3 | 0.760 |
ERK2 |
0.704 | -0.080 | 1 | 0.269 |
KHS1 |
0.704 | 0.210 | 1 | 0.560 |
MSK1 |
0.704 | -0.056 | -3 | 0.693 |
MEK5 |
0.704 | -0.072 | 2 | 0.744 |
PRP4 |
0.703 | -0.040 | -3 | 0.727 |
PKCT |
0.703 | -0.050 | 2 | 0.681 |
AKT2 |
0.703 | -0.034 | -3 | 0.645 |
BRSK1 |
0.703 | -0.055 | -3 | 0.737 |
PRKX |
0.703 | -0.033 | -3 | 0.619 |
RSK4 |
0.703 | -0.044 | -3 | 0.695 |
CAMK2A |
0.703 | -0.060 | 2 | 0.673 |
HIPK1 |
0.702 | -0.070 | 1 | 0.273 |
MNK1 |
0.702 | -0.079 | -2 | 0.238 |
TAO2 |
0.702 | 0.017 | 2 | 0.787 |
TAK1 |
0.701 | 0.088 | 1 | 0.441 |
CHK1 |
0.701 | -0.092 | -3 | 0.772 |
IRAK4 |
0.701 | -0.106 | 1 | 0.369 |
MYLK4 |
0.701 | -0.087 | -2 | 0.225 |
KHS2 |
0.701 | 0.191 | 1 | 0.554 |
DYRK1A |
0.700 | -0.068 | 1 | 0.292 |
MPSK1 |
0.700 | -0.077 | 1 | 0.303 |
PIM2 |
0.700 | -0.055 | -3 | 0.705 |
CDK9 |
0.700 | -0.087 | 1 | 0.260 |
AKT1 |
0.700 | -0.034 | -3 | 0.657 |
HPK1 |
0.700 | 0.159 | 1 | 0.532 |
HIPK3 |
0.700 | -0.079 | 1 | 0.311 |
WNK4 |
0.700 | -0.094 | -2 | 0.253 |
SNRK |
0.699 | -0.136 | 2 | 0.603 |
MAPKAPK5 |
0.699 | -0.101 | -3 | 0.675 |
NEK11 |
0.699 | 0.012 | 1 | 0.444 |
SLK |
0.698 | 0.050 | -2 | 0.242 |
CAMKK2 |
0.698 | -0.068 | -2 | 0.218 |
MEK2 |
0.698 | 0.032 | 2 | 0.737 |
DCAMKL1 |
0.696 | -0.074 | -3 | 0.724 |
SSTK |
0.696 | -0.084 | 4 | 0.846 |
EEF2K |
0.696 | 0.015 | 3 | 0.813 |
CLK2 |
0.695 | -0.028 | -3 | 0.686 |
P70S6K |
0.695 | -0.057 | -3 | 0.672 |
JNK1 |
0.695 | -0.047 | 1 | 0.219 |
CK1G1 |
0.695 | 0.003 | -3 | 0.453 |
PKCI |
0.695 | -0.064 | 2 | 0.686 |
PDK1 |
0.695 | -0.052 | 1 | 0.394 |
DRAK1 |
0.694 | -0.147 | 1 | 0.253 |
NEK1 |
0.694 | 0.008 | 1 | 0.407 |
CK2A2 |
0.694 | -0.009 | 1 | 0.176 |
CDK16 |
0.694 | -0.063 | 1 | 0.187 |
GRK3 |
0.693 | -0.086 | -2 | 0.230 |
DYRK1B |
0.693 | -0.083 | 1 | 0.227 |
DYRK4 |
0.693 | -0.081 | 1 | 0.224 |
CDK14 |
0.692 | -0.081 | 1 | 0.245 |
NEK3 |
0.692 | -0.013 | 1 | 0.430 |
PKG1 |
0.692 | -0.041 | -2 | 0.147 |
IRAK1 |
0.692 | -0.123 | -1 | 0.740 |
CDK6 |
0.692 | -0.058 | 1 | 0.242 |
LKB1 |
0.692 | -0.063 | -3 | 0.807 |
RIPK2 |
0.691 | -0.068 | 1 | 0.423 |
DCAMKL2 |
0.691 | -0.072 | -3 | 0.759 |
YSK1 |
0.691 | -0.004 | 2 | 0.747 |
MAP3K15 |
0.690 | -0.045 | 1 | 0.431 |
DYRK3 |
0.690 | -0.087 | 1 | 0.279 |
ERK7 |
0.689 | -0.055 | 2 | 0.464 |
MRCKB |
0.689 | -0.016 | -3 | 0.692 |
SMMLCK |
0.689 | -0.100 | -3 | 0.783 |
MAK |
0.689 | -0.044 | -2 | 0.179 |
PKCE |
0.689 | -0.041 | 2 | 0.669 |
MEKK6 |
0.689 | -0.070 | 1 | 0.422 |
OSR1 |
0.689 | 0.053 | 2 | 0.733 |
AKT3 |
0.689 | -0.031 | -3 | 0.578 |
VRK1 |
0.689 | -0.087 | 2 | 0.755 |
MRCKA |
0.688 | -0.015 | -3 | 0.705 |
GAK |
0.688 | -0.096 | 1 | 0.317 |
PKN1 |
0.687 | -0.060 | -3 | 0.686 |
CAMK1G |
0.687 | -0.119 | -3 | 0.722 |
MYO3A |
0.687 | 0.096 | 1 | 0.466 |
CDK4 |
0.687 | -0.070 | 1 | 0.236 |
ROCK2 |
0.685 | -0.020 | -3 | 0.727 |
SGK1 |
0.684 | -0.030 | -3 | 0.561 |
CDK10 |
0.684 | -0.075 | 1 | 0.225 |
BUB1 |
0.684 | -0.031 | -5 | 0.706 |
TAO1 |
0.683 | 0.035 | 1 | 0.456 |
DAPK3 |
0.682 | -0.086 | -3 | 0.742 |
CK1E |
0.682 | -0.087 | -3 | 0.452 |
CK2A1 |
0.681 | -0.035 | 1 | 0.171 |
LRRK2 |
0.681 | -0.108 | 2 | 0.759 |
GSK3B |
0.681 | -0.036 | 4 | 0.419 |
MYO3B |
0.680 | 0.019 | 2 | 0.774 |
CAMK1D |
0.679 | -0.086 | -3 | 0.628 |
STK33 |
0.679 | -0.104 | 2 | 0.539 |
CK1D |
0.679 | -0.059 | -3 | 0.403 |
PBK |
0.679 | -0.078 | 1 | 0.300 |
GSK3A |
0.678 | -0.036 | 4 | 0.426 |
PASK |
0.678 | -0.127 | -3 | 0.801 |
CHK2 |
0.677 | -0.044 | -3 | 0.592 |
BIKE |
0.676 | -0.029 | 1 | 0.261 |
STLK3 |
0.676 | 0.026 | 1 | 0.428 |
MOK |
0.676 | -0.079 | 1 | 0.258 |
ROCK1 |
0.675 | -0.028 | -3 | 0.698 |
ASK1 |
0.673 | -0.053 | 1 | 0.424 |
DAPK1 |
0.673 | -0.101 | -3 | 0.726 |
CAMK1A |
0.672 | -0.078 | -3 | 0.613 |
CK1A2 |
0.671 | -0.072 | -3 | 0.400 |
NEK10_TYR |
0.670 | 0.115 | 1 | 0.431 |
ALPHAK3 |
0.670 | -0.007 | -1 | 0.737 |
TYK2 |
0.669 | 0.103 | 1 | 0.440 |
JAK1 |
0.669 | 0.147 | 1 | 0.468 |
PDHK3_TYR |
0.669 | 0.030 | 4 | 0.905 |
HASPIN |
0.668 | -0.060 | -1 | 0.604 |
JAK2 |
0.667 | 0.090 | 1 | 0.446 |
DMPK1 |
0.667 | -0.057 | -3 | 0.714 |
AAK1 |
0.667 | -0.012 | 1 | 0.219 |
CRIK |
0.665 | -0.044 | -3 | 0.664 |
RET |
0.664 | 0.033 | 1 | 0.420 |
SBK |
0.663 | -0.059 | -3 | 0.532 |
MAP2K4_TYR |
0.661 | -0.019 | -1 | 0.827 |
TESK1_TYR |
0.661 | -0.096 | 3 | 0.838 |
BMPR2_TYR |
0.660 | 0.001 | -1 | 0.823 |
ROS1 |
0.660 | 0.035 | 3 | 0.720 |
MST1R |
0.659 | 0.017 | 3 | 0.740 |
CSF1R |
0.658 | 0.031 | 3 | 0.714 |
MAP2K7_TYR |
0.658 | -0.116 | 2 | 0.764 |
MAP2K6_TYR |
0.657 | -0.024 | -1 | 0.823 |
PDHK1_TYR |
0.656 | -0.048 | -1 | 0.848 |
PDHK4_TYR |
0.656 | -0.054 | 2 | 0.781 |
TXK |
0.656 | 0.055 | 1 | 0.270 |
LCK |
0.656 | 0.048 | -1 | 0.873 |
PKMYT1_TYR |
0.656 | -0.135 | 3 | 0.795 |
PINK1_TYR |
0.656 | -0.141 | 1 | 0.339 |
EPHA6 |
0.656 | -0.009 | -1 | 0.842 |
HCK |
0.655 | 0.026 | -1 | 0.867 |
LIMK2_TYR |
0.655 | -0.089 | -3 | 0.857 |
ABL2 |
0.655 | 0.000 | -1 | 0.821 |
TYRO3 |
0.654 | -0.043 | 3 | 0.744 |
FLT3 |
0.653 | 0.016 | 3 | 0.726 |
EPHB4 |
0.653 | -0.026 | -1 | 0.825 |
YES1 |
0.652 | -0.008 | -1 | 0.874 |
FGR |
0.652 | -0.023 | 1 | 0.326 |
TNNI3K_TYR |
0.651 | -0.036 | 1 | 0.397 |
JAK3 |
0.651 | -0.042 | 1 | 0.369 |
BLK |
0.651 | 0.036 | -1 | 0.867 |
PDGFRB |
0.651 | -0.045 | 3 | 0.738 |
ABL1 |
0.651 | -0.023 | -1 | 0.827 |
KIT |
0.648 | -0.007 | 3 | 0.712 |
LIMK1_TYR |
0.648 | -0.150 | 2 | 0.784 |
INSRR |
0.648 | 0.017 | 3 | 0.680 |
ITK |
0.648 | -0.015 | -1 | 0.831 |
SRMS |
0.648 | -0.024 | 1 | 0.322 |
PDGFRA |
0.647 | -0.024 | 3 | 0.738 |
PTK6 |
0.647 | -0.012 | -1 | 0.770 |
YANK3 |
0.647 | -0.070 | 2 | 0.345 |
FGFR1 |
0.647 | -0.050 | 3 | 0.698 |
BTK |
0.646 | -0.010 | -1 | 0.804 |
EPHB1 |
0.646 | -0.046 | 1 | 0.344 |
FER |
0.645 | -0.074 | 1 | 0.321 |
EPHB2 |
0.645 | -0.018 | -1 | 0.824 |
FYN |
0.645 | 0.026 | -1 | 0.849 |
TEC |
0.644 | 0.013 | -1 | 0.786 |
FGFR2 |
0.644 | -0.061 | 3 | 0.717 |
KDR |
0.643 | -0.045 | 3 | 0.683 |
AXL |
0.642 | -0.066 | 3 | 0.700 |
ALK |
0.642 | -0.022 | 3 | 0.648 |
FRK |
0.642 | 0.002 | -1 | 0.866 |
EPHB3 |
0.642 | -0.060 | -1 | 0.819 |
DDR1 |
0.642 | -0.152 | 4 | 0.839 |
EGFR |
0.642 | -0.005 | 1 | 0.311 |
CK1A |
0.642 | -0.074 | -3 | 0.310 |
TNK1 |
0.642 | -0.085 | 3 | 0.720 |
TNK2 |
0.642 | -0.059 | 3 | 0.669 |
BMX |
0.641 | -0.018 | -1 | 0.745 |
MERTK |
0.641 | -0.054 | 3 | 0.697 |
ERBB2 |
0.641 | -0.027 | 1 | 0.376 |
LYN |
0.641 | 0.006 | 3 | 0.644 |
EPHA4 |
0.639 | -0.048 | 2 | 0.656 |
MET |
0.639 | -0.039 | 3 | 0.702 |
LTK |
0.639 | -0.049 | 3 | 0.673 |
NTRK2 |
0.639 | -0.044 | 3 | 0.675 |
TEK |
0.639 | -0.067 | 3 | 0.669 |
NTRK1 |
0.638 | -0.048 | -1 | 0.786 |
CK1G3 |
0.638 | -0.018 | -3 | 0.266 |
FLT1 |
0.637 | -0.022 | -1 | 0.806 |
SRC |
0.636 | -0.011 | -1 | 0.856 |
INSR |
0.636 | -0.052 | 3 | 0.659 |
EPHA1 |
0.635 | -0.043 | 3 | 0.676 |
NTRK3 |
0.635 | -0.053 | -1 | 0.738 |
FGFR4 |
0.635 | -0.008 | -1 | 0.770 |
EPHA7 |
0.635 | -0.050 | 2 | 0.664 |
FGFR3 |
0.634 | -0.060 | 3 | 0.690 |
WEE1_TYR |
0.633 | -0.092 | -1 | 0.724 |
FLT4 |
0.633 | -0.063 | 3 | 0.680 |
EPHA3 |
0.629 | -0.066 | 2 | 0.635 |
PTK2B |
0.629 | -0.047 | -1 | 0.835 |
CSK |
0.628 | -0.076 | 2 | 0.667 |
EPHA8 |
0.627 | -0.045 | -1 | 0.800 |
SYK |
0.627 | -0.014 | -1 | 0.753 |
MUSK |
0.626 | -0.081 | 1 | 0.302 |
DDR2 |
0.626 | -0.105 | 3 | 0.657 |
EPHA5 |
0.626 | -0.053 | 2 | 0.639 |
MATK |
0.624 | -0.091 | -1 | 0.731 |
IGF1R |
0.621 | -0.043 | 3 | 0.600 |
PTK2 |
0.621 | -0.033 | -1 | 0.772 |
ERBB4 |
0.620 | -0.035 | 1 | 0.286 |
EPHA2 |
0.619 | -0.053 | -1 | 0.765 |
YANK2 |
0.619 | -0.081 | 2 | 0.360 |
CK1G2 |
0.615 | -0.064 | -3 | 0.365 |
ZAP70 |
0.609 | -0.047 | -1 | 0.667 |
FES |
0.604 | -0.091 | -1 | 0.738 |