Motif 687 (n=62)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A8MW92 | PHF20L1 | S313 | ochoa | PHD finger protein 20-like protein 1 | Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity). {ECO:0000250|UniProtKB:Q8CCJ9, ECO:0000269|PubMed:24492612, ECO:0000269|PubMed:29358331}. |
M0QZ92 | None | S40 | ochoa | SEC7 domain-containing protein | None |
O60237 | PPP1R12B | S842 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
O60293 | ZFC3H1 | S381 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
O75167 | PHACTR2 | S560 | ochoa | Phosphatase and actin regulator 2 | None |
P07942 | LAMB1 | S1666 | ochoa | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}. |
P11055 | MYH3 | S1367 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
P12882 | MYH1 | S1370 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
P12883 | MYH7 | S1366 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P13533 | MYH6 | S1368 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
P13535 | MYH8 | S1369 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
P26038 | MSN | S429 | ochoa | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
P31327 | CPS1 | S1193 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
P37275 | ZEB1 | S1100 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
P42566 | EPS15 | S470 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
P54259 | ATN1 | T92 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
P78362 | SRPK2 | S312 | ochoa | SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. |
P78559 | MAP1A | S1626 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
Q01850 | CDR2 | S210 | ochoa | Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen) | None |
Q02952 | AKAP12 | S1755 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
Q07157 | TJP1 | S1139 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q08357 | SLC20A2 | S458 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
Q13428 | TCOF1 | S107 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
Q14978 | NOLC1 | S582 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
Q16851 | UGP2 | S45 | ochoa | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) | UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390, ECO:0000269|PubMed:8631325}. |
Q49MG5 | MAP9 | S289 | ochoa|psp | Microtubule-associated protein 9 (Aster-associated protein) | Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules. {ECO:0000269|PubMed:16049101}. |
Q4G0J3 | LARP7 | S249 | ochoa | La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) | RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}. |
Q5T1M5 | FKBP15 | S960 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
Q5TB80 | CEP162 | S144 | ochoa | Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) | Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. {ECO:0000269|PubMed:23644468}. |
Q5XG99 | LYSMD4 | S58 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 4 | None |
Q6NTE8 | MRNIP | S100 | psp | MRN complex-interacting protein (MRN-interacting protein) | Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553). |
Q6WCQ1 | MPRIP | S800 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
Q7Z3K3 | POGZ | S1364 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
Q86WN1 | FCHSD1 | S435 | ochoa | F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2) | Promotes actin polymerization mediated by SNX9 and WASL. {ECO:0000250|UniProtKB:Q6PFY1}. |
Q8TCP9 | FAM200A | S46 | ochoa | Protein FAM200A | None |
Q8WU17 | RNF139 | S634 | ochoa | E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein) | E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death (PubMed:10500182, PubMed:12032852, PubMed:17016439). Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) (PubMed:19720873). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression (PubMed:19706601, PubMed:20068067). Involved in the sterol-accelerated degradation of HMGCR (PubMed:22143767, PubMed:23223569). This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane (PubMed:22143767). In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:22143767, PubMed:23223569). Required for INSIG1 ubiquitination (PubMed:20068067). May be required for EIF3 complex ubiquitination (PubMed:20068067). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12032852, ECO:0000269|PubMed:17016439, ECO:0000269|PubMed:19706601, ECO:0000269|PubMed:19720873, ECO:0000269|PubMed:20068067, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:23223569}. |
Q8WWI1 | LMO7 | S847 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
Q92541 | RTF1 | S262 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
Q92625 | ANKS1A | Y922 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
Q96SB4 | SRPK1 | S309 | ochoa|psp | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. |
Q99418 | CYTH2 | S56 | ochoa | Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) | Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}. |
Q99623 | PHB2 | S243 | psp | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}. |
Q9BRK5 | SDF4 | S209 | ochoa | 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. |
Q9NR45 | NANS | S134 | ochoa | N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase) | Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289). {ECO:0000269|PubMed:10749855, ECO:0000269|PubMed:27213289}. |
Q9NRA8 | EIF4ENIF1 | S379 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
Q9P2E9 | RRBP1 | S896 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
Q9UKV3 | ACIN1 | S453 | psp | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
Q9UKX2 | MYH2 | T1372 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
Q9UKX3 | MYH13 | S1370 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
Q9ULU4 | ZMYND8 | S1090 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
Q9ULW0 | TPX2 | S102 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
Q9Y266 | NUDC | S97 | ochoa | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
Q9Y623 | MYH4 | S1370 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
Q9Y6X4 | FAM169A | S398 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
Q9UPN3 | MACF1 | S2769 | Sugiyama | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
Q01970 | PLCB3 | S1041 | Sugiyama | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}. |
P14927 | UQCRB | Y56 | Sugiyama | Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000250|UniProtKB:P00128}. |
P45379 | TNNT2 | S189 | EPSD|PSP | Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT) | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
Q8TF05 | PPP4R1 | S57 | Sugiyama | Serine/threonine-protein phosphatase 4 regulatory subunit 1 | Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. {ECO:0000269|PubMed:15805470}.; FUNCTION: (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. {ECO:0000269|PubMed:28445980}. |
P35580 | MYH10 | S1371 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
P02533 | KRT14 | S321 | Sugiyama | Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14) | The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. {ECO:0000269|PubMed:11724817}. |
Q04695 | KRT17 | S290 | Sugiyama | Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17) | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. {ECO:0000250|UniProtKB:Q9QWL7, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:15795121, ECO:0000269|PubMed:16713453}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-390522 | Striated Muscle Contraction | 0.000032 | 4.490 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.000525 | 3.279 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.000599 | 3.222 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.004904 | 2.309 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.005449 | 2.264 |
R-HSA-6809371 | Formation of the cornified envelope | 0.003320 | 2.479 |
R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.004748 | 2.323 |
R-HSA-9694631 | Maturation of nucleoprotein | 0.005156 | 2.288 |
R-HSA-9734767 | Developmental Cell Lineages | 0.008363 | 2.078 |
R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 0.013141 | 1.881 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.012423 | 1.906 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.016237 | 1.790 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.015883 | 1.799 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.015883 | 1.799 |
R-HSA-6805567 | Keratinization | 0.017914 | 1.747 |
R-HSA-397014 | Muscle contraction | 0.019509 | 1.710 |
R-HSA-6811438 | Intra-Golgi traffic | 0.020026 | 1.698 |
R-HSA-191650 | Regulation of gap junction activity | 0.026113 | 1.583 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.026113 | 1.583 |
R-HSA-75153 | Apoptotic execution phase | 0.023982 | 1.620 |
R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.096503 | 1.015 |
R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.116234 | 0.935 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.275735 | 0.560 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.278935 | 0.554 |
R-HSA-3000157 | Laminin interactions | 0.127868 | 0.893 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.198122 | 0.703 |
R-HSA-8949664 | Processing of SMDT1 | 0.072251 | 1.141 |
R-HSA-9865881 | Complex III assembly | 0.124007 | 0.907 |
R-HSA-500657 | Presynaptic function of Kainate receptors | 0.096503 | 1.015 |
R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.183811 | 0.736 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.232826 | 0.633 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.236213 | 0.627 |
R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.084456 | 1.073 |
R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.124007 | 0.907 |
R-HSA-8949215 | Mitochondrial calcium ion transport | 0.112322 | 0.950 |
R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.088489 | 1.053 |
R-HSA-437239 | Recycling pathway of L1 | 0.215663 | 0.666 |
R-HSA-182971 | EGFR downregulation | 0.150685 | 0.822 |
R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.150685 | 0.822 |
R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.034667 | 1.460 |
R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.120129 | 0.920 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.135540 | 0.868 |
R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 0.076337 | 1.117 |
R-HSA-8874081 | MET activates PTK2 signaling | 0.131712 | 0.880 |
R-HSA-9930044 | Nuclear RNA decay | 0.158159 | 0.801 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.039563 | 1.403 |
R-HSA-446107 | Type I hemidesmosome assembly | 0.047359 | 1.325 |
R-HSA-9840373 | Cellular response to mitochondrial stress | 0.051553 | 1.288 |
R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.139351 | 0.856 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.259519 | 0.586 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.104447 | 0.981 |
R-HSA-9638630 | Attachment of bacteria to epithelial cells | 0.131712 | 0.880 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.285295 | 0.545 |
R-HSA-397795 | G-protein beta:gamma signalling | 0.158159 | 0.801 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.259519 | 0.586 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.080406 | 1.095 |
R-HSA-70635 | Urea cycle | 0.131712 | 0.880 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.222573 | 0.653 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.232826 | 0.633 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.246289 | 0.609 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.291600 | 0.535 |
R-HSA-177929 | Signaling by EGFR | 0.246289 | 0.609 |
R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.135540 | 0.868 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.047359 | 1.325 |
R-HSA-9766229 | Degradation of CDH1 | 0.222573 | 0.653 |
R-HSA-112043 | PLC beta mediated events | 0.262790 | 0.580 |
R-HSA-373760 | L1CAM interactions | 0.112590 | 0.949 |
R-HSA-9931953 | Biofilm formation | 0.180194 | 0.744 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.207689 | 0.683 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.207689 | 0.683 |
R-HSA-6807004 | Negative regulation of MET activity | 0.104447 | 0.981 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.158159 | 0.801 |
R-HSA-8875878 | MET promotes cell motility | 0.180194 | 0.744 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.112322 | 0.950 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.127868 | 0.893 |
R-HSA-901042 | Calnexin/calreticulin cycle | 0.165568 | 0.781 |
R-HSA-156588 | Glucuronidation | 0.239586 | 0.621 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.161872 | 0.791 |
R-HSA-112040 | G-protein mediated events | 0.282122 | 0.550 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.244971 | 0.611 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.249618 | 0.603 |
R-HSA-418990 | Adherens junctions interactions | 0.282525 | 0.549 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.222573 | 0.653 |
R-HSA-446728 | Cell junction organization | 0.144602 | 0.840 |
R-HSA-1500931 | Cell-Cell communication | 0.185132 | 0.733 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.180194 | 0.744 |
R-HSA-4085001 | Sialic acid metabolism | 0.256233 | 0.591 |
R-HSA-3322077 | Glycogen synthesis | 0.104447 | 0.981 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.251494 | 0.599 |
R-HSA-6806834 | Signaling by MET | 0.057921 | 1.237 |
R-HSA-1266738 | Developmental Biology | 0.152909 | 0.816 |
R-HSA-69275 | G2/M Transition | 0.228702 | 0.641 |
R-HSA-2028269 | Signaling by Hippo | 0.092505 | 1.034 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.169249 | 0.771 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.231950 | 0.635 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.041557 | 1.381 |
R-HSA-8982491 | Glycogen metabolism | 0.187412 | 0.727 |
R-HSA-373755 | Semaphorin interactions | 0.269291 | 0.570 |
R-HSA-9694635 | Translation of Structural Proteins | 0.054491 | 1.264 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.238455 | 0.623 |
R-HSA-9020591 | Interleukin-12 signaling | 0.053365 | 1.273 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.169594 | 0.771 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.074857 | 1.126 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.222487 | 0.653 |
R-HSA-109581 | Apoptosis | 0.188502 | 0.725 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.211366 | 0.675 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.274359 | 0.562 |
R-HSA-5357801 | Programmed Cell Death | 0.261290 | 0.583 |
R-HSA-447115 | Interleukin-12 family signaling | 0.067419 | 1.171 |
R-HSA-3000178 | ECM proteoglycans | 0.294732 | 0.531 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.295577 | 0.529 |
R-HSA-4086398 | Ca2+ pathway | 0.300955 | 0.521 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.304046 | 0.517 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.307123 | 0.513 |
R-HSA-8852135 | Protein ubiquitination | 0.307123 | 0.513 |
R-HSA-449147 | Signaling by Interleukins | 0.318090 | 0.497 |
R-HSA-9659379 | Sensory processing of sound | 0.319300 | 0.496 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.334224 | 0.476 |
R-HSA-421270 | Cell-cell junction organization | 0.336111 | 0.474 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.337170 | 0.472 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.340103 | 0.468 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.340103 | 0.468 |
R-HSA-199991 | Membrane Trafficking | 0.341224 | 0.467 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.343023 | 0.465 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.354577 | 0.450 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.363111 | 0.440 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.382593 | 0.417 |
R-HSA-422356 | Regulation of insulin secretion | 0.382593 | 0.417 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.388051 | 0.411 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.393461 | 0.405 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.398824 | 0.399 |
R-HSA-111885 | Opioid Signalling | 0.398824 | 0.399 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.414634 | 0.382 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.422384 | 0.374 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.430033 | 0.366 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.449947 | 0.347 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.454817 | 0.342 |
R-HSA-422475 | Axon guidance | 0.457319 | 0.340 |
R-HSA-114608 | Platelet degranulation | 0.466807 | 0.331 |
R-HSA-9679506 | SARS-CoV Infections | 0.468814 | 0.329 |
R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.478537 | 0.320 |
R-HSA-1474228 | Degradation of the extracellular matrix | 0.480852 | 0.318 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.481339 | 0.318 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.483157 | 0.316 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.492277 | 0.308 |
R-HSA-163685 | Integration of energy metabolism | 0.492277 | 0.308 |
R-HSA-6807070 | PTEN Regulation | 0.499013 | 0.302 |
R-HSA-9675108 | Nervous system development | 0.499316 | 0.302 |
R-HSA-5653656 | Vesicle-mediated transport | 0.500092 | 0.301 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.501239 | 0.300 |
R-HSA-9664407 | Parasite infection | 0.501239 | 0.300 |
R-HSA-9664417 | Leishmania phagocytosis | 0.501239 | 0.300 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.503455 | 0.298 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.510044 | 0.292 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.533477 | 0.273 |
R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.539673 | 0.268 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.543875 | 0.265 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.545789 | 0.263 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.553818 | 0.257 |
R-HSA-5619102 | SLC transporter disorders | 0.559748 | 0.252 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.575184 | 0.240 |
R-HSA-611105 | Respiratory electron transport | 0.582701 | 0.235 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.584873 | 0.233 |
R-HSA-2559583 | Cellular Senescence | 0.586410 | 0.232 |
R-HSA-5617833 | Cilium Assembly | 0.604474 | 0.219 |
R-HSA-68877 | Mitotic Prometaphase | 0.609739 | 0.215 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.611479 | 0.214 |
R-HSA-9640148 | Infection with Enterobacteria | 0.626797 | 0.203 |
R-HSA-1640170 | Cell Cycle | 0.628905 | 0.201 |
R-HSA-72172 | mRNA Splicing | 0.630120 | 0.201 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.643120 | 0.192 |
R-HSA-68882 | Mitotic Anaphase | 0.649450 | 0.187 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.651015 | 0.186 |
R-HSA-8951664 | Neddylation | 0.657207 | 0.182 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.667784 | 0.175 |
R-HSA-156580 | Phase II - Conjugation of compounds | 0.683757 | 0.165 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.694896 | 0.158 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.709583 | 0.149 |
R-HSA-416476 | G alpha (q) signalling events | 0.717298 | 0.144 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.719645 | 0.143 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.729710 | 0.137 |
R-HSA-1643685 | Disease | 0.734758 | 0.134 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.735713 | 0.133 |
R-HSA-9658195 | Leishmania infection | 0.738077 | 0.132 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.738077 | 0.132 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.739251 | 0.131 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.754052 | 0.123 |
R-HSA-195721 | Signaling by WNT | 0.757348 | 0.121 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.774260 | 0.111 |
R-HSA-5663205 | Infectious disease | 0.779156 | 0.108 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.780225 | 0.108 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.783175 | 0.106 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.783175 | 0.106 |
R-HSA-1474244 | Extracellular matrix organization | 0.790853 | 0.102 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.800073 | 0.097 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.800973 | 0.096 |
R-HSA-68886 | M Phase | 0.834616 | 0.079 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.835362 | 0.078 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.845468 | 0.073 |
R-HSA-418594 | G alpha (i) signalling events | 0.852309 | 0.069 |
R-HSA-597592 | Post-translational protein modification | 0.874985 | 0.058 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.881208 | 0.055 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.886486 | 0.052 |
R-HSA-162582 | Signal Transduction | 0.887222 | 0.052 |
R-HSA-112316 | Neuronal System | 0.888024 | 0.052 |
R-HSA-9824446 | Viral Infection Pathways | 0.889439 | 0.051 |
R-HSA-8953854 | Metabolism of RNA | 0.896850 | 0.047 |
R-HSA-211859 | Biological oxidations | 0.912840 | 0.040 |
R-HSA-382551 | Transport of small molecules | 0.940332 | 0.027 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.943575 | 0.025 |
R-HSA-74160 | Gene expression (Transcription) | 0.948220 | 0.023 |
R-HSA-2262752 | Cellular responses to stress | 0.948238 | 0.023 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.952291 | 0.021 |
R-HSA-8953897 | Cellular responses to stimuli | 0.968519 | 0.014 |
R-HSA-388396 | GPCR downstream signalling | 0.972532 | 0.012 |
R-HSA-109582 | Hemostasis | 0.973777 | 0.012 |
R-HSA-212436 | Generic Transcription Pathway | 0.974409 | 0.011 |
R-HSA-372790 | Signaling by GPCR | 0.981328 | 0.008 |
R-HSA-392499 | Metabolism of proteins | 0.987511 | 0.005 |
R-HSA-168256 | Immune System | 0.989522 | 0.005 |
R-HSA-1280218 | Adaptive Immune System | 0.992308 | 0.003 |
R-HSA-9709957 | Sensory Perception | 0.996897 | 0.001 |
R-HSA-168249 | Innate Immune System | 0.998004 | 0.001 |
R-HSA-1430728 | Metabolism | 0.999988 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.777 | 0.201 | 1 | 0.791 |
PRKD1 |
0.770 | 0.253 | -3 | 0.739 |
PRKD2 |
0.764 | 0.187 | -3 | 0.761 |
COT |
0.760 | 0.037 | 2 | 0.810 |
TSSK2 |
0.757 | 0.218 | -5 | 0.721 |
PIM1 |
0.756 | 0.124 | -3 | 0.743 |
MAPKAPK2 |
0.756 | 0.134 | -3 | 0.720 |
CHK1 |
0.756 | 0.248 | -3 | 0.769 |
NUAK2 |
0.755 | 0.127 | -3 | 0.778 |
CAMK1B |
0.754 | 0.112 | -3 | 0.762 |
CDC7 |
0.754 | 0.112 | 1 | 0.795 |
PIM3 |
0.753 | 0.063 | -3 | 0.743 |
MAPKAPK3 |
0.753 | 0.133 | -3 | 0.746 |
NUAK1 |
0.751 | 0.124 | -3 | 0.758 |
TSSK1 |
0.750 | 0.171 | -3 | 0.793 |
MOS |
0.750 | 0.094 | 1 | 0.794 |
SRPK1 |
0.750 | 0.083 | -3 | 0.686 |
PRPK |
0.750 | -0.019 | -1 | 0.672 |
CAMK2B |
0.750 | 0.139 | 2 | 0.721 |
CLK2 |
0.749 | 0.141 | -3 | 0.728 |
CLK1 |
0.749 | 0.145 | -3 | 0.739 |
SRPK2 |
0.749 | 0.091 | -3 | 0.631 |
AMPKA1 |
0.749 | 0.115 | -3 | 0.788 |
PRKD3 |
0.748 | 0.151 | -3 | 0.730 |
CDKL1 |
0.748 | 0.046 | -3 | 0.694 |
KIS |
0.748 | 0.078 | 1 | 0.607 |
AMPKA2 |
0.748 | 0.116 | -3 | 0.781 |
NDR2 |
0.748 | 0.029 | -3 | 0.746 |
CAMK2A |
0.747 | 0.129 | 2 | 0.738 |
BMPR1B |
0.746 | 0.176 | 1 | 0.728 |
PKN3 |
0.746 | 0.046 | -3 | 0.731 |
LATS2 |
0.746 | 0.050 | -5 | 0.499 |
CAMK2D |
0.745 | 0.085 | -3 | 0.741 |
CLK4 |
0.745 | 0.100 | -3 | 0.726 |
RAF1 |
0.745 | -0.022 | 1 | 0.674 |
SKMLCK |
0.745 | 0.057 | -2 | 0.653 |
DSTYK |
0.744 | -0.030 | 2 | 0.797 |
BMPR2 |
0.744 | -0.022 | -2 | 0.726 |
MTOR |
0.743 | -0.064 | 1 | 0.632 |
NIK |
0.743 | 0.069 | -3 | 0.764 |
FAM20C |
0.743 | 0.071 | 2 | 0.560 |
ATR |
0.742 | -0.010 | 1 | 0.699 |
ERK5 |
0.742 | 0.010 | 1 | 0.689 |
NLK |
0.742 | 0.009 | 1 | 0.696 |
RSK2 |
0.741 | 0.034 | -3 | 0.712 |
MARK4 |
0.741 | 0.036 | 4 | 0.710 |
DAPK2 |
0.741 | 0.063 | -3 | 0.740 |
ATM |
0.741 | 0.036 | 1 | 0.663 |
MELK |
0.741 | 0.108 | -3 | 0.768 |
CAMK2G |
0.740 | -0.040 | 2 | 0.752 |
P90RSK |
0.740 | 0.035 | -3 | 0.693 |
CAMK4 |
0.740 | 0.063 | -3 | 0.772 |
CDKL5 |
0.739 | 0.020 | -3 | 0.690 |
CHAK2 |
0.739 | 0.044 | -1 | 0.683 |
TBK1 |
0.739 | -0.078 | 1 | 0.541 |
HIPK4 |
0.739 | 0.043 | 1 | 0.672 |
PDHK4 |
0.738 | -0.184 | 1 | 0.684 |
IKKB |
0.738 | -0.097 | -2 | 0.573 |
TGFBR1 |
0.738 | 0.114 | -2 | 0.739 |
WNK1 |
0.738 | 0.019 | -2 | 0.668 |
LATS1 |
0.738 | 0.067 | -3 | 0.717 |
SIK |
0.737 | 0.089 | -3 | 0.731 |
PKN2 |
0.737 | 0.032 | -3 | 0.778 |
NDR1 |
0.737 | -0.001 | -3 | 0.759 |
IKKA |
0.737 | -0.021 | -2 | 0.582 |
CAMLCK |
0.737 | -0.001 | -2 | 0.639 |
TGFBR2 |
0.736 | 0.011 | -2 | 0.712 |
GRK6 |
0.735 | 0.001 | 1 | 0.705 |
ALK4 |
0.735 | 0.097 | -2 | 0.746 |
ICK |
0.735 | 0.018 | -3 | 0.717 |
JNK2 |
0.735 | 0.099 | 1 | 0.549 |
GCN2 |
0.735 | -0.130 | 2 | 0.709 |
ALK2 |
0.735 | 0.167 | -2 | 0.720 |
P70S6KB |
0.735 | 0.027 | -3 | 0.740 |
BMPR1A |
0.735 | 0.187 | 1 | 0.726 |
PKCD |
0.735 | 0.028 | 2 | 0.727 |
DCAMKL1 |
0.735 | 0.112 | -3 | 0.782 |
SRPK3 |
0.735 | 0.047 | -3 | 0.648 |
CAMK1D |
0.734 | 0.122 | -3 | 0.707 |
ACVR2B |
0.734 | 0.116 | -2 | 0.730 |
CDK8 |
0.734 | 0.032 | 1 | 0.580 |
NEK6 |
0.733 | -0.063 | -2 | 0.722 |
MSK2 |
0.733 | 0.014 | -3 | 0.673 |
CDK18 |
0.733 | 0.058 | 1 | 0.561 |
HUNK |
0.733 | -0.085 | 2 | 0.742 |
DYRK2 |
0.732 | 0.056 | 1 | 0.581 |
ULK2 |
0.732 | -0.143 | 2 | 0.715 |
QSK |
0.732 | 0.050 | 4 | 0.675 |
MNK2 |
0.732 | 0.038 | -2 | 0.584 |
RSK3 |
0.732 | 0.007 | -3 | 0.711 |
GRK5 |
0.732 | -0.088 | -3 | 0.662 |
PRKX |
0.731 | 0.068 | -3 | 0.710 |
ACVR2A |
0.731 | 0.084 | -2 | 0.723 |
JNK3 |
0.731 | 0.077 | 1 | 0.586 |
MSK1 |
0.731 | 0.024 | -3 | 0.698 |
IKKE |
0.731 | -0.118 | 1 | 0.533 |
PKACB |
0.730 | 0.038 | -2 | 0.459 |
CDK19 |
0.730 | 0.035 | 1 | 0.549 |
NEK7 |
0.730 | -0.127 | -3 | 0.598 |
P38A |
0.729 | 0.055 | 1 | 0.617 |
MYLK4 |
0.729 | 0.023 | -2 | 0.557 |
PDHK1 |
0.729 | -0.196 | 1 | 0.656 |
MST4 |
0.729 | -0.028 | 2 | 0.742 |
GRK7 |
0.728 | 0.022 | 1 | 0.671 |
BRSK1 |
0.728 | 0.030 | -3 | 0.756 |
DCAMKL2 |
0.728 | 0.091 | -3 | 0.790 |
MARK3 |
0.728 | 0.045 | 4 | 0.650 |
CDK5 |
0.728 | 0.047 | 1 | 0.635 |
CAMK1G |
0.728 | 0.045 | -3 | 0.714 |
NIM1 |
0.728 | -0.036 | 3 | 0.679 |
AURC |
0.728 | -0.001 | -2 | 0.439 |
CDK1 |
0.727 | 0.041 | 1 | 0.579 |
MARK2 |
0.727 | 0.031 | 4 | 0.612 |
QIK |
0.727 | -0.000 | -3 | 0.735 |
DNAPK |
0.727 | 0.031 | 1 | 0.571 |
CDK7 |
0.727 | 0.023 | 1 | 0.610 |
AKT2 |
0.726 | 0.047 | -3 | 0.682 |
MNK1 |
0.726 | 0.036 | -2 | 0.591 |
WNK3 |
0.726 | -0.146 | 1 | 0.635 |
PKACG |
0.726 | -0.031 | -2 | 0.499 |
DLK |
0.726 | -0.111 | 1 | 0.636 |
MAPKAPK5 |
0.725 | 0.013 | -3 | 0.645 |
CAMK1A |
0.725 | 0.121 | -3 | 0.698 |
RIPK3 |
0.725 | -0.129 | 3 | 0.646 |
ULK1 |
0.725 | -0.135 | -3 | 0.604 |
SSTK |
0.725 | 0.079 | 4 | 0.676 |
P38B |
0.725 | 0.047 | 1 | 0.568 |
NEK9 |
0.725 | -0.108 | 2 | 0.739 |
SBK |
0.725 | 0.109 | -3 | 0.612 |
CDK2 |
0.725 | 0.023 | 1 | 0.628 |
BRSK2 |
0.725 | 0.014 | -3 | 0.770 |
PKCB |
0.724 | 0.007 | 2 | 0.669 |
RSK4 |
0.724 | 0.019 | -3 | 0.683 |
PLK1 |
0.724 | -0.060 | -2 | 0.682 |
P38G |
0.724 | 0.053 | 1 | 0.498 |
CDK16 |
0.724 | 0.065 | 1 | 0.543 |
HIPK2 |
0.724 | 0.069 | 1 | 0.522 |
PHKG1 |
0.724 | 0.012 | -3 | 0.767 |
MASTL |
0.724 | -0.191 | -2 | 0.619 |
MLK1 |
0.724 | -0.153 | 2 | 0.724 |
DYRK1A |
0.723 | 0.048 | 1 | 0.638 |
PIM2 |
0.723 | 0.034 | -3 | 0.713 |
CDK17 |
0.723 | 0.037 | 1 | 0.516 |
PAK1 |
0.723 | -0.026 | -2 | 0.563 |
BCKDK |
0.723 | -0.080 | -1 | 0.730 |
CHK2 |
0.723 | 0.103 | -3 | 0.675 |
GRK1 |
0.723 | -0.041 | -2 | 0.552 |
SMG1 |
0.723 | -0.016 | 1 | 0.656 |
IRE2 |
0.723 | -0.055 | 2 | 0.707 |
CDK13 |
0.722 | 0.012 | 1 | 0.588 |
MLK2 |
0.722 | -0.096 | 2 | 0.733 |
MARK1 |
0.722 | 0.019 | 4 | 0.679 |
P38D |
0.722 | 0.070 | 1 | 0.524 |
ANKRD3 |
0.721 | -0.143 | 1 | 0.648 |
GRK4 |
0.721 | -0.107 | -2 | 0.639 |
PAK3 |
0.721 | -0.044 | -2 | 0.571 |
IRE1 |
0.720 | -0.090 | 1 | 0.625 |
HIPK1 |
0.720 | 0.052 | 1 | 0.598 |
CDK3 |
0.720 | 0.055 | 1 | 0.537 |
PKR |
0.720 | -0.058 | 1 | 0.674 |
BRAF |
0.720 | 0.022 | -4 | 0.747 |
ERK1 |
0.720 | 0.025 | 1 | 0.556 |
SGK3 |
0.720 | 0.020 | -3 | 0.740 |
DYRK4 |
0.719 | 0.059 | 1 | 0.537 |
PKACA |
0.719 | 0.025 | -2 | 0.421 |
MEK1 |
0.718 | -0.115 | 2 | 0.771 |
PAK6 |
0.718 | 0.017 | -2 | 0.492 |
PKCZ |
0.718 | -0.038 | 2 | 0.695 |
DAPK3 |
0.718 | 0.069 | -3 | 0.755 |
AURB |
0.718 | -0.026 | -2 | 0.436 |
ERK2 |
0.718 | 0.004 | 1 | 0.599 |
PASK |
0.717 | 0.030 | -3 | 0.720 |
RIPK1 |
0.717 | -0.172 | 1 | 0.609 |
PLK3 |
0.717 | -0.066 | 2 | 0.706 |
TLK2 |
0.717 | -0.046 | 1 | 0.634 |
YSK4 |
0.717 | -0.095 | 1 | 0.579 |
AKT1 |
0.716 | 0.039 | -3 | 0.708 |
PKG2 |
0.716 | -0.015 | -2 | 0.449 |
PINK1 |
0.716 | -0.087 | 1 | 0.718 |
HIPK3 |
0.715 | 0.052 | 1 | 0.577 |
CDK14 |
0.715 | 0.031 | 1 | 0.584 |
PRP4 |
0.715 | 0.009 | -3 | 0.605 |
DYRK1B |
0.715 | 0.040 | 1 | 0.565 |
PHKG2 |
0.715 | 0.033 | -3 | 0.793 |
CDK9 |
0.715 | 0.005 | 1 | 0.587 |
PKCH |
0.715 | -0.043 | 2 | 0.657 |
SMMLCK |
0.714 | -0.002 | -3 | 0.735 |
CHAK1 |
0.714 | -0.085 | 2 | 0.658 |
HRI |
0.714 | -0.079 | -2 | 0.726 |
TLK1 |
0.713 | -0.029 | -2 | 0.729 |
PKCG |
0.713 | -0.057 | 2 | 0.660 |
CDK12 |
0.713 | 0.003 | 1 | 0.558 |
MLK3 |
0.713 | -0.101 | 2 | 0.659 |
VRK2 |
0.713 | -0.210 | 1 | 0.691 |
PAK2 |
0.712 | -0.078 | -2 | 0.539 |
PKCA |
0.711 | -0.057 | 2 | 0.658 |
DRAK1 |
0.711 | -0.083 | 1 | 0.590 |
GRK2 |
0.711 | -0.083 | -2 | 0.546 |
AURA |
0.711 | -0.043 | -2 | 0.420 |
DAPK1 |
0.711 | 0.040 | -3 | 0.734 |
NEK2 |
0.710 | -0.122 | 2 | 0.713 |
DYRK3 |
0.710 | 0.016 | 1 | 0.577 |
GSK3A |
0.710 | -0.003 | 4 | 0.408 |
TTBK2 |
0.710 | -0.177 | 2 | 0.597 |
NEK5 |
0.710 | -0.063 | 1 | 0.653 |
SNRK |
0.710 | -0.097 | 2 | 0.631 |
BUB1 |
0.709 | 0.130 | -5 | 0.717 |
TAO3 |
0.709 | -0.011 | 1 | 0.606 |
JNK1 |
0.708 | 0.041 | 1 | 0.559 |
CK2A2 |
0.708 | 0.031 | 1 | 0.651 |
CDK10 |
0.708 | 0.031 | 1 | 0.575 |
P70S6K |
0.707 | -0.021 | -3 | 0.672 |
IRAK4 |
0.707 | -0.076 | 1 | 0.620 |
PKN1 |
0.706 | 0.027 | -3 | 0.704 |
PERK |
0.706 | -0.115 | -2 | 0.707 |
GSK3B |
0.706 | -0.026 | 4 | 0.394 |
MLK4 |
0.706 | -0.127 | 2 | 0.639 |
GAK |
0.705 | 0.001 | 1 | 0.722 |
CK1E |
0.705 | -0.060 | -3 | 0.402 |
SGK1 |
0.704 | 0.028 | -3 | 0.623 |
WNK4 |
0.704 | -0.102 | -2 | 0.663 |
PKCT |
0.704 | -0.046 | 2 | 0.667 |
MRCKA |
0.704 | 0.026 | -3 | 0.735 |
PLK4 |
0.703 | -0.119 | 2 | 0.580 |
MEKK2 |
0.703 | -0.132 | 2 | 0.728 |
MEKK3 |
0.703 | -0.179 | 1 | 0.584 |
TAO2 |
0.702 | -0.037 | 2 | 0.771 |
MEK5 |
0.702 | -0.224 | 2 | 0.745 |
ZAK |
0.702 | -0.150 | 1 | 0.552 |
AKT3 |
0.701 | 0.017 | -3 | 0.637 |
MRCKB |
0.701 | 0.023 | -3 | 0.736 |
EEF2K |
0.701 | -0.002 | 3 | 0.746 |
MEKK1 |
0.700 | -0.183 | 1 | 0.597 |
CDK6 |
0.700 | 0.021 | 1 | 0.566 |
CDK4 |
0.700 | 0.020 | 1 | 0.555 |
GCK |
0.699 | -0.018 | 1 | 0.614 |
MPSK1 |
0.699 | -0.049 | 1 | 0.661 |
DMPK1 |
0.699 | 0.062 | -3 | 0.767 |
MST2 |
0.699 | -0.055 | 1 | 0.616 |
ERK7 |
0.699 | -0.022 | 2 | 0.445 |
MST3 |
0.699 | -0.086 | 2 | 0.732 |
ROCK2 |
0.698 | 0.025 | -3 | 0.758 |
PDK1 |
0.697 | -0.064 | 1 | 0.612 |
MAK |
0.697 | 0.023 | -2 | 0.527 |
CK1D |
0.697 | -0.070 | -3 | 0.360 |
PKCI |
0.696 | -0.065 | 2 | 0.661 |
CAMKK1 |
0.696 | -0.155 | -2 | 0.572 |
PAK5 |
0.696 | -0.041 | -2 | 0.421 |
CK2A1 |
0.696 | -0.000 | 1 | 0.619 |
PKCE |
0.696 | -0.026 | 2 | 0.644 |
LKB1 |
0.696 | -0.103 | -3 | 0.649 |
NEK8 |
0.696 | -0.165 | 2 | 0.733 |
TNIK |
0.695 | -0.019 | 3 | 0.775 |
GRK3 |
0.695 | -0.089 | -2 | 0.508 |
PLK2 |
0.695 | -0.038 | -3 | 0.616 |
NEK11 |
0.693 | -0.157 | 1 | 0.585 |
IRAK1 |
0.693 | -0.176 | -1 | 0.565 |
HGK |
0.692 | -0.066 | 3 | 0.772 |
MOK |
0.692 | 0.010 | 1 | 0.609 |
LRRK2 |
0.692 | -0.105 | 2 | 0.751 |
NEK1 |
0.691 | -0.078 | 1 | 0.612 |
TAK1 |
0.691 | -0.093 | 1 | 0.673 |
CAMKK2 |
0.691 | -0.160 | -2 | 0.566 |
NEK4 |
0.690 | -0.138 | 1 | 0.597 |
KHS1 |
0.690 | -0.006 | 1 | 0.588 |
MEKK6 |
0.690 | -0.097 | 1 | 0.597 |
TTK |
0.690 | 0.006 | -2 | 0.698 |
KHS2 |
0.690 | 0.004 | 1 | 0.606 |
MINK |
0.690 | -0.082 | 1 | 0.594 |
HPK1 |
0.690 | -0.053 | 1 | 0.591 |
PBK |
0.690 | -0.002 | 1 | 0.653 |
CK1A2 |
0.689 | -0.082 | -3 | 0.372 |
SLK |
0.689 | -0.057 | -2 | 0.502 |
PAK4 |
0.689 | -0.049 | -2 | 0.430 |
CK1G1 |
0.689 | -0.100 | -3 | 0.387 |
ROCK1 |
0.689 | 0.017 | -3 | 0.747 |
MAP3K15 |
0.689 | -0.089 | 1 | 0.546 |
MST1 |
0.688 | -0.080 | 1 | 0.591 |
LOK |
0.688 | -0.075 | -2 | 0.561 |
CRIK |
0.687 | 0.014 | -3 | 0.689 |
BIKE |
0.687 | 0.045 | 1 | 0.627 |
VRK1 |
0.686 | -0.117 | 2 | 0.790 |
PDHK3_TYR |
0.685 | 0.074 | 4 | 0.783 |
PKG1 |
0.684 | -0.036 | -2 | 0.395 |
ALPHAK3 |
0.684 | 0.008 | -1 | 0.585 |
TTBK1 |
0.683 | -0.179 | 2 | 0.534 |
PDHK4_TYR |
0.680 | 0.016 | 2 | 0.804 |
AAK1 |
0.680 | 0.079 | 1 | 0.553 |
MAP2K6_TYR |
0.680 | -0.006 | -1 | 0.705 |
HASPIN |
0.678 | -0.033 | -1 | 0.480 |
MAP2K4_TYR |
0.677 | -0.057 | -1 | 0.699 |
MEK2 |
0.677 | -0.216 | 2 | 0.733 |
RIPK2 |
0.676 | -0.221 | 1 | 0.509 |
TESK1_TYR |
0.676 | -0.047 | 3 | 0.776 |
PDHK1_TYR |
0.675 | -0.017 | -1 | 0.704 |
YSK1 |
0.674 | -0.129 | 2 | 0.706 |
OSR1 |
0.674 | -0.097 | 2 | 0.714 |
EPHB4 |
0.672 | 0.076 | -1 | 0.703 |
LIMK2_TYR |
0.670 | -0.036 | -3 | 0.746 |
MAP2K7_TYR |
0.670 | -0.205 | 2 | 0.780 |
STK33 |
0.670 | -0.189 | 2 | 0.537 |
TAO1 |
0.669 | -0.077 | 1 | 0.513 |
NEK3 |
0.669 | -0.180 | 1 | 0.541 |
PINK1_TYR |
0.669 | -0.149 | 1 | 0.687 |
INSRR |
0.668 | -0.007 | 3 | 0.671 |
MYO3B |
0.668 | -0.091 | 2 | 0.723 |
TYRO3 |
0.667 | -0.038 | 3 | 0.721 |
FER |
0.667 | 0.010 | 1 | 0.766 |
PKMYT1_TYR |
0.667 | -0.146 | 3 | 0.749 |
EPHA6 |
0.667 | 0.023 | -1 | 0.672 |
ROS1 |
0.667 | -0.035 | 3 | 0.704 |
BMPR2_TYR |
0.666 | -0.123 | -1 | 0.650 |
EPHB3 |
0.665 | 0.079 | -1 | 0.703 |
ASK1 |
0.665 | -0.140 | 1 | 0.541 |
ABL2 |
0.665 | -0.011 | -1 | 0.647 |
EPHB2 |
0.665 | 0.086 | -1 | 0.680 |
EPHA4 |
0.665 | 0.048 | 2 | 0.710 |
YES1 |
0.665 | -0.027 | -1 | 0.660 |
RET |
0.664 | -0.096 | 1 | 0.612 |
TXK |
0.664 | 0.035 | 1 | 0.696 |
DDR1 |
0.664 | -0.063 | 4 | 0.718 |
MYO3A |
0.664 | -0.110 | 1 | 0.584 |
LIMK1_TYR |
0.663 | -0.142 | 2 | 0.773 |
EPHB1 |
0.663 | 0.047 | 1 | 0.689 |
CSF1R |
0.662 | -0.081 | 3 | 0.716 |
SRMS |
0.662 | 0.017 | 1 | 0.725 |
CK1A |
0.660 | -0.090 | -3 | 0.285 |
ABL1 |
0.660 | -0.029 | -1 | 0.637 |
MST1R |
0.659 | -0.127 | 3 | 0.727 |
TYK2 |
0.659 | -0.158 | 1 | 0.613 |
BLK |
0.658 | 0.011 | -1 | 0.625 |
TNK2 |
0.658 | -0.036 | 3 | 0.695 |
FGR |
0.658 | -0.108 | 1 | 0.697 |
YANK3 |
0.657 | -0.101 | 2 | 0.340 |
JAK2 |
0.656 | -0.147 | 1 | 0.603 |
TEK |
0.656 | -0.048 | 3 | 0.670 |
HCK |
0.655 | -0.061 | -1 | 0.612 |
EPHA5 |
0.655 | 0.056 | 2 | 0.710 |
JAK3 |
0.655 | -0.123 | 1 | 0.590 |
LCK |
0.654 | -0.037 | -1 | 0.600 |
DDR2 |
0.654 | -0.009 | 3 | 0.671 |
STLK3 |
0.654 | -0.169 | 1 | 0.528 |
TEC |
0.654 | -0.006 | -1 | 0.583 |
AXL |
0.653 | -0.060 | 3 | 0.688 |
FGFR2 |
0.653 | -0.118 | 3 | 0.700 |
FLT3 |
0.653 | -0.103 | 3 | 0.725 |
MERTK |
0.653 | -0.043 | 3 | 0.692 |
KIT |
0.652 | -0.113 | 3 | 0.712 |
ALK |
0.652 | -0.048 | 3 | 0.668 |
ITK |
0.652 | -0.058 | -1 | 0.600 |
BMX |
0.652 | -0.025 | -1 | 0.541 |
TNK1 |
0.652 | -0.078 | 3 | 0.701 |
LTK |
0.651 | -0.046 | 3 | 0.680 |
EPHA7 |
0.651 | 0.004 | 2 | 0.714 |
PDGFRB |
0.650 | -0.136 | 3 | 0.725 |
FGFR1 |
0.650 | -0.122 | 3 | 0.688 |
EPHA3 |
0.650 | -0.042 | 2 | 0.686 |
PTK2B |
0.649 | -0.011 | -1 | 0.615 |
TNNI3K_TYR |
0.649 | -0.080 | 1 | 0.591 |
NEK10_TYR |
0.649 | -0.119 | 1 | 0.534 |
KDR |
0.649 | -0.132 | 3 | 0.684 |
FRK |
0.648 | -0.027 | -1 | 0.653 |
FYN |
0.647 | -0.044 | -1 | 0.563 |
BTK |
0.647 | -0.093 | -1 | 0.588 |
MET |
0.646 | -0.122 | 3 | 0.710 |
NTRK1 |
0.646 | -0.115 | -1 | 0.681 |
INSR |
0.646 | -0.094 | 3 | 0.652 |
CK1G3 |
0.646 | -0.091 | -3 | 0.251 |
PDGFRA |
0.646 | -0.149 | 3 | 0.720 |
EPHA1 |
0.644 | -0.051 | 3 | 0.703 |
FGFR3 |
0.644 | -0.130 | 3 | 0.676 |
EPHA8 |
0.643 | -0.029 | -1 | 0.648 |
JAK1 |
0.643 | -0.125 | 1 | 0.524 |
PTK6 |
0.642 | -0.132 | -1 | 0.558 |
NTRK3 |
0.641 | -0.099 | -1 | 0.655 |
LYN |
0.641 | -0.076 | 3 | 0.637 |
MATK |
0.639 | -0.113 | -1 | 0.587 |
NTRK2 |
0.639 | -0.158 | 3 | 0.654 |
SRC |
0.637 | -0.080 | -1 | 0.588 |
ERBB2 |
0.637 | -0.162 | 1 | 0.593 |
SYK |
0.637 | -0.027 | -1 | 0.555 |
FLT1 |
0.637 | -0.171 | -1 | 0.635 |
FLT4 |
0.637 | -0.164 | 3 | 0.659 |
WEE1_TYR |
0.636 | -0.146 | -1 | 0.566 |
CSK |
0.635 | -0.109 | 2 | 0.712 |
EGFR |
0.635 | -0.090 | 1 | 0.510 |
EPHA2 |
0.635 | -0.041 | -1 | 0.601 |
FGFR4 |
0.633 | -0.110 | -1 | 0.603 |
PTK2 |
0.632 | -0.074 | -1 | 0.541 |
IGF1R |
0.630 | -0.115 | 3 | 0.592 |
MUSK |
0.629 | -0.084 | 1 | 0.500 |
ERBB4 |
0.628 | -0.072 | 1 | 0.554 |
CK1G2 |
0.626 | -0.101 | -3 | 0.326 |
YANK2 |
0.625 | -0.127 | 2 | 0.363 |
FES |
0.616 | -0.107 | -1 | 0.517 |
ZAP70 |
0.614 | -0.085 | -1 | 0.492 |