Motif 687 (n=62)

Position-wise Probabilities

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uniprot genes site source protein function
A8MW92 PHF20L1 S313 ochoa PHD finger protein 20-like protein 1 Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity). {ECO:0000250|UniProtKB:Q8CCJ9, ECO:0000269|PubMed:24492612, ECO:0000269|PubMed:29358331}.
M0QZ92 None S40 ochoa SEC7 domain-containing protein None
O60237 PPP1R12B S842 ochoa Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}.
O60293 ZFC3H1 S381 ochoa Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}.
O75167 PHACTR2 S560 ochoa Phosphatase and actin regulator 2 None
P07942 LAMB1 S1666 ochoa Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}.
P11055 MYH3 S1367 ochoa Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) Muscle contraction.
P12882 MYH1 S1370 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 S1366 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13533 MYH6 S1368 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13535 MYH8 S1369 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P26038 MSN S429 ochoa Moesin (Membrane-organizing extension spike protein) Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}.
P31327 CPS1 S1193 ochoa Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
P37275 ZEB1 S1100 ochoa Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}.
P42566 EPS15 S470 ochoa Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.
P54259 ATN1 T92 ochoa Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}.
P78362 SRPK2 S312 ochoa SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}.
P78559 MAP1A S1626 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Q01850 CDR2 S210 ochoa Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen) None
Q02952 AKAP12 S1755 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q07157 TJP1 S1139 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q08357 SLC20A2 S458 ochoa Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}.
Q13428 TCOF1 S107 ochoa Treacle protein (Treacher Collins syndrome protein) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.
Q14978 NOLC1 S582 ochoa Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}.
Q16851 UGP2 S45 ochoa UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390, ECO:0000269|PubMed:8631325}.
Q49MG5 MAP9 S289 ochoa|psp Microtubule-associated protein 9 (Aster-associated protein) Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules. {ECO:0000269|PubMed:16049101}.
Q4G0J3 LARP7 S249 ochoa La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}.
Q5T1M5 FKBP15 S960 ochoa FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}.
Q5TB80 CEP162 S144 ochoa Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. {ECO:0000269|PubMed:23644468}.
Q5XG99 LYSMD4 S58 ochoa LysM and putative peptidoglycan-binding domain-containing protein 4 None
Q6NTE8 MRNIP S100 psp MRN complex-interacting protein (MRN-interacting protein) Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).
Q6WCQ1 MPRIP S800 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q7Z3K3 POGZ S1364 ochoa Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}.
Q86WN1 FCHSD1 S435 ochoa F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2) Promotes actin polymerization mediated by SNX9 and WASL. {ECO:0000250|UniProtKB:Q6PFY1}.
Q8TCP9 FAM200A S46 ochoa Protein FAM200A None
Q8WU17 RNF139 S634 ochoa E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein) E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death (PubMed:10500182, PubMed:12032852, PubMed:17016439). Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) (PubMed:19720873). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression (PubMed:19706601, PubMed:20068067). Involved in the sterol-accelerated degradation of HMGCR (PubMed:22143767, PubMed:23223569). This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane (PubMed:22143767). In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:22143767, PubMed:23223569). Required for INSIG1 ubiquitination (PubMed:20068067). May be required for EIF3 complex ubiquitination (PubMed:20068067). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12032852, ECO:0000269|PubMed:17016439, ECO:0000269|PubMed:19706601, ECO:0000269|PubMed:19720873, ECO:0000269|PubMed:20068067, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:23223569}.
Q8WWI1 LMO7 S847 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q92541 RTF1 S262 ochoa RNA polymerase-associated protein RTF1 homolog Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}.
Q92625 ANKS1A Y922 ochoa Ankyrin repeat and SAM domain-containing protein 1A (Odin) Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}.
Q96SB4 SRPK1 S309 ochoa|psp SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}.
Q99418 CYTH2 S56 ochoa Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}.
Q99623 PHB2 S243 psp Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}.
Q9BRK5 SDF4 S209 ochoa 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.
Q9NR45 NANS S134 ochoa N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase) Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289). {ECO:0000269|PubMed:10749855, ECO:0000269|PubMed:27213289}.
Q9NRA8 EIF4ENIF1 S379 ochoa Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}.
Q9P2E9 RRBP1 S896 ochoa Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.
Q9UKV3 ACIN1 S453 psp Apoptotic chromatin condensation inducer in the nucleus (Acinus) Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}.
Q9UKX2 MYH2 T1372 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX3 MYH13 S1370 ochoa Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}.
Q9ULU4 ZMYND8 S1090 ochoa MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}.
Q9ULW0 TPX2 S102 ochoa Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.
Q9Y266 NUDC S97 ochoa Nuclear migration protein nudC (Nuclear distribution protein C homolog) Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}.
Q9Y623 MYH4 S1370 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
Q9Y6X4 FAM169A S398 ochoa Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) None
Q9UPN3 MACF1 S2769 Sugiyama Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.
Q01970 PLCB3 S1041 Sugiyama 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}.
P14927 UQCRB Y56 Sugiyama Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000250|UniProtKB:P00128}.
P45379 TNNT2 S189 EPSD|PSP Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT) Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Q8TF05 PPP4R1 S57 Sugiyama Serine/threonine-protein phosphatase 4 regulatory subunit 1 Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. {ECO:0000269|PubMed:15805470}.; FUNCTION: (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. {ECO:0000269|PubMed:28445980}.
P35580 MYH10 S1371 Sugiyama Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}.
P02533 KRT14 S321 Sugiyama Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14) The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. {ECO:0000269|PubMed:11724817}.
Q04695 KRT17 S290 Sugiyama Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17) Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. {ECO:0000250|UniProtKB:Q9QWL7, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:15795121, ECO:0000269|PubMed:16713453}.
Download
reactome_id name p -log10_p
R-HSA-390522 Striated Muscle Contraction 0.000032 4.490
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.000525 3.279
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.000599 3.222
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.004904 2.309
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.005449 2.264
R-HSA-6809371 Formation of the cornified envelope 0.003320 2.479
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 0.004748 2.323
R-HSA-9694631 Maturation of nucleoprotein 0.005156 2.288
R-HSA-9734767 Developmental Cell Lineages 0.008363 2.078
R-HSA-5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) 0.013141 1.881
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.012423 1.906
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.016237 1.790
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.015883 1.799
R-HSA-9700206 Signaling by ALK in cancer 0.015883 1.799
R-HSA-6805567 Keratinization 0.017914 1.747
R-HSA-397014 Muscle contraction 0.019509 1.710
R-HSA-6811438 Intra-Golgi traffic 0.020026 1.698
R-HSA-191650 Regulation of gap junction activity 0.026113 1.583
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.026113 1.583
R-HSA-75153 Apoptotic execution phase 0.023982 1.620
R-HSA-418217 G beta:gamma signalling through PLC beta 0.096503 1.015
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 0.116234 0.935
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.275735 0.560
R-HSA-8854518 AURKA Activation by TPX2 0.278935 0.554
R-HSA-3000157 Laminin interactions 0.127868 0.893
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.198122 0.703
R-HSA-8949664 Processing of SMDT1 0.072251 1.141
R-HSA-9865881 Complex III assembly 0.124007 0.907
R-HSA-500657 Presynaptic function of Kainate receptors 0.096503 1.015
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.183811 0.736
R-HSA-112382 Formation of RNA Pol II elongation complex 0.232826 0.633
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.236213 0.627
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 0.084456 1.073
R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus 0.124007 0.907
R-HSA-8949215 Mitochondrial calcium ion transport 0.112322 0.950
R-HSA-399997 Acetylcholine regulates insulin secretion 0.088489 1.053
R-HSA-437239 Recycling pathway of L1 0.215663 0.666
R-HSA-182971 EGFR downregulation 0.150685 0.822
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.150685 0.822
R-HSA-427652 Sodium-coupled phosphate cotransporters 0.034667 1.460
R-HSA-400451 Free fatty acids regulate insulin secretion 0.120129 0.920
R-HSA-3928663 EPHA-mediated growth cone collapse 0.135540 0.868
R-HSA-173599 Formation of the active cofactor, UDP-glucuronate 0.076337 1.117
R-HSA-8874081 MET activates PTK2 signaling 0.131712 0.880
R-HSA-9930044 Nuclear RNA decay 0.158159 0.801
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.039563 1.403
R-HSA-446107 Type I hemidesmosome assembly 0.047359 1.325
R-HSA-9840373 Cellular response to mitochondrial stress 0.051553 1.288
R-HSA-451326 Activation of kainate receptors upon glutamate binding 0.139351 0.856
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.259519 0.586
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.104447 0.981
R-HSA-9638630 Attachment of bacteria to epithelial cells 0.131712 0.880
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.285295 0.545
R-HSA-397795 G-protein beta:gamma signalling 0.158159 0.801
R-HSA-8943724 Regulation of PTEN gene transcription 0.259519 0.586
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.080406 1.095
R-HSA-70635 Urea cycle 0.131712 0.880
R-HSA-157858 Gap junction trafficking and regulation 0.222573 0.653
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.232826 0.633
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.246289 0.609
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.291600 0.535
R-HSA-177929 Signaling by EGFR 0.246289 0.609
R-HSA-901032 ER Quality Control Compartment (ERQC) 0.135540 0.868
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.047359 1.325
R-HSA-9766229 Degradation of CDH1 0.222573 0.653
R-HSA-112043 PLC beta mediated events 0.262790 0.580
R-HSA-373760 L1CAM interactions 0.112590 0.949
R-HSA-9931953 Biofilm formation 0.180194 0.744
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.207689 0.683
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.207689 0.683
R-HSA-6807004 Negative regulation of MET activity 0.104447 0.981
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.158159 0.801
R-HSA-8875878 MET promotes cell motility 0.180194 0.744
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.112322 0.950
R-HSA-400685 Sema4D in semaphorin signaling 0.127868 0.893
R-HSA-901042 Calnexin/calreticulin cycle 0.165568 0.781
R-HSA-156588 Glucuronidation 0.239586 0.621
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.161872 0.791
R-HSA-112040 G-protein mediated events 0.282122 0.550
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.244971 0.611
R-HSA-9764561 Regulation of CDH1 Function 0.249618 0.603
R-HSA-418990 Adherens junctions interactions 0.282525 0.549
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.222573 0.653
R-HSA-446728 Cell junction organization 0.144602 0.840
R-HSA-1500931 Cell-Cell communication 0.185132 0.733
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.180194 0.744
R-HSA-4085001 Sialic acid metabolism 0.256233 0.591
R-HSA-3322077 Glycogen synthesis 0.104447 0.981
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.251494 0.599
R-HSA-6806834 Signaling by MET 0.057921 1.237
R-HSA-1266738 Developmental Biology 0.152909 0.816
R-HSA-69275 G2/M Transition 0.228702 0.641
R-HSA-2028269 Signaling by Hippo 0.092505 1.034
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.169249 0.771
R-HSA-453274 Mitotic G2-G2/M phases 0.231950 0.635
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.041557 1.381
R-HSA-8982491 Glycogen metabolism 0.187412 0.727
R-HSA-373755 Semaphorin interactions 0.269291 0.570
R-HSA-9694635 Translation of Structural Proteins 0.054491 1.264
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.238455 0.623
R-HSA-9020591 Interleukin-12 signaling 0.053365 1.273
R-HSA-9856651 MITF-M-dependent gene expression 0.169594 0.771
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.074857 1.126
R-HSA-9694516 SARS-CoV-2 Infection 0.222487 0.653
R-HSA-109581 Apoptosis 0.188502 0.725
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.211366 0.675
R-HSA-9730414 MITF-M-regulated melanocyte development 0.274359 0.562
R-HSA-5357801 Programmed Cell Death 0.261290 0.583
R-HSA-447115 Interleukin-12 family signaling 0.067419 1.171
R-HSA-3000178 ECM proteoglycans 0.294732 0.531
R-HSA-8878171 Transcriptional regulation by RUNX1 0.295577 0.529
R-HSA-4086398 Ca2+ pathway 0.300955 0.521
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.304046 0.517
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.307123 0.513
R-HSA-8852135 Protein ubiquitination 0.307123 0.513
R-HSA-449147 Signaling by Interleukins 0.318090 0.497
R-HSA-9659379 Sensory processing of sound 0.319300 0.496
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.334224 0.476
R-HSA-421270 Cell-cell junction organization 0.336111 0.474
R-HSA-6802957 Oncogenic MAPK signaling 0.337170 0.472
R-HSA-141424 Amplification of signal from the kinetochores 0.340103 0.468
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.340103 0.468
R-HSA-199991 Membrane Trafficking 0.341224 0.467
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.343023 0.465
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.354577 0.450
R-HSA-2682334 EPH-Ephrin signaling 0.363111 0.440
R-HSA-8957275 Post-translational protein phosphorylation 0.382593 0.417
R-HSA-422356 Regulation of insulin secretion 0.382593 0.417
R-HSA-69618 Mitotic Spindle Checkpoint 0.388051 0.411
R-HSA-2559580 Oxidative Stress Induced Senescence 0.393461 0.405
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.398824 0.399
R-HSA-111885 Opioid Signalling 0.398824 0.399
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.414634 0.382
R-HSA-1483249 Inositol phosphate metabolism 0.422384 0.374
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.430033 0.366
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.449947 0.347
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.454817 0.342
R-HSA-422475 Axon guidance 0.457319 0.340
R-HSA-114608 Platelet degranulation 0.466807 0.331
R-HSA-9679506 SARS-CoV Infections 0.468814 0.329
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 0.478537 0.320
R-HSA-1474228 Degradation of the extracellular matrix 0.480852 0.318
R-HSA-69278 Cell Cycle, Mitotic 0.481339 0.318
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.483157 0.316
R-HSA-3858494 Beta-catenin independent WNT signaling 0.492277 0.308
R-HSA-163685 Integration of energy metabolism 0.492277 0.308
R-HSA-6807070 PTEN Regulation 0.499013 0.302
R-HSA-9675108 Nervous system development 0.499316 0.302
R-HSA-5653656 Vesicle-mediated transport 0.500092 0.301
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.501239 0.300
R-HSA-9664407 Parasite infection 0.501239 0.300
R-HSA-9664417 Leishmania phagocytosis 0.501239 0.300
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.503455 0.298
R-HSA-8856828 Clathrin-mediated endocytosis 0.510044 0.292
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.533477 0.273
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 0.539673 0.268
R-HSA-9824439 Bacterial Infection Pathways 0.543875 0.265
R-HSA-5633007 Regulation of TP53 Activity 0.545789 0.263
R-HSA-2467813 Separation of Sister Chromatids 0.553818 0.257
R-HSA-5619102 SLC transporter disorders 0.559748 0.252
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.575184 0.240
R-HSA-611105 Respiratory electron transport 0.582701 0.235
R-HSA-446203 Asparagine N-linked glycosylation 0.584873 0.233
R-HSA-2559583 Cellular Senescence 0.586410 0.232
R-HSA-5617833 Cilium Assembly 0.604474 0.219
R-HSA-68877 Mitotic Prometaphase 0.609739 0.215
R-HSA-72163 mRNA Splicing - Major Pathway 0.611479 0.214
R-HSA-9640148 Infection with Enterobacteria 0.626797 0.203
R-HSA-1640170 Cell Cycle 0.628905 0.201
R-HSA-72172 mRNA Splicing 0.630120 0.201
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.643120 0.192
R-HSA-68882 Mitotic Anaphase 0.649450 0.187
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.651015 0.186
R-HSA-8951664 Neddylation 0.657207 0.182
R-HSA-9705683 SARS-CoV-2-host interactions 0.667784 0.175
R-HSA-156580 Phase II - Conjugation of compounds 0.683757 0.165
R-HSA-5619115 Disorders of transmembrane transporters 0.694896 0.158
R-HSA-69620 Cell Cycle Checkpoints 0.709583 0.149
R-HSA-416476 G alpha (q) signalling events 0.717298 0.144
R-HSA-1280215 Cytokine Signaling in Immune system 0.719645 0.143
R-HSA-76002 Platelet activation, signaling and aggregation 0.729710 0.137
R-HSA-1643685 Disease 0.734758 0.134
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.735713 0.133
R-HSA-9658195 Leishmania infection 0.738077 0.132
R-HSA-9824443 Parasitic Infection Pathways 0.738077 0.132
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.739251 0.131
R-HSA-1257604 PIP3 activates AKT signaling 0.754052 0.123
R-HSA-195721 Signaling by WNT 0.757348 0.121
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.774260 0.111
R-HSA-5663205 Infectious disease 0.779156 0.108
R-HSA-1852241 Organelle biogenesis and maintenance 0.780225 0.108
R-HSA-212165 Epigenetic regulation of gene expression 0.783175 0.106
R-HSA-112315 Transmission across Chemical Synapses 0.783175 0.106
R-HSA-1474244 Extracellular matrix organization 0.790853 0.102
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.800073 0.097
R-HSA-9006925 Intracellular signaling by second messengers 0.800973 0.096
R-HSA-68886 M Phase 0.834616 0.079
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.835362 0.078
R-HSA-425407 SLC-mediated transmembrane transport 0.845468 0.073
R-HSA-418594 G alpha (i) signalling events 0.852309 0.069
R-HSA-597592 Post-translational protein modification 0.874985 0.058
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.881208 0.055
R-HSA-3700989 Transcriptional Regulation by TP53 0.886486 0.052
R-HSA-162582 Signal Transduction 0.887222 0.052
R-HSA-112316 Neuronal System 0.888024 0.052
R-HSA-9824446 Viral Infection Pathways 0.889439 0.051
R-HSA-8953854 Metabolism of RNA 0.896850 0.047
R-HSA-211859 Biological oxidations 0.912840 0.040
R-HSA-382551 Transport of small molecules 0.940332 0.027
R-HSA-71291 Metabolism of amino acids and derivatives 0.943575 0.025
R-HSA-74160 Gene expression (Transcription) 0.948220 0.023
R-HSA-2262752 Cellular responses to stress 0.948238 0.023
R-HSA-73857 RNA Polymerase II Transcription 0.952291 0.021
R-HSA-8953897 Cellular responses to stimuli 0.968519 0.014
R-HSA-388396 GPCR downstream signalling 0.972532 0.012
R-HSA-109582 Hemostasis 0.973777 0.012
R-HSA-212436 Generic Transcription Pathway 0.974409 0.011
R-HSA-372790 Signaling by GPCR 0.981328 0.008
R-HSA-392499 Metabolism of proteins 0.987511 0.005
R-HSA-168256 Immune System 0.989522 0.005
R-HSA-1280218 Adaptive Immune System 0.992308 0.003
R-HSA-9709957 Sensory Perception 0.996897 0.001
R-HSA-168249 Innate Immune System 0.998004 0.001
R-HSA-1430728 Metabolism 0.999988 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.777 0.201 1 0.791
PRKD1PRKD1 0.770 0.253 -3 0.739
PRKD2PRKD2 0.764 0.187 -3 0.761
COTCOT 0.760 0.037 2 0.810
TSSK2TSSK2 0.757 0.218 -5 0.721
PIM1PIM1 0.756 0.124 -3 0.743
MAPKAPK2MAPKAPK2 0.756 0.134 -3 0.720
CHK1CHK1 0.756 0.248 -3 0.769
NUAK2NUAK2 0.755 0.127 -3 0.778
CAMK1BCAMK1B 0.754 0.112 -3 0.762
CDC7CDC7 0.754 0.112 1 0.795
PIM3PIM3 0.753 0.063 -3 0.743
MAPKAPK3MAPKAPK3 0.753 0.133 -3 0.746
NUAK1NUAK1 0.751 0.124 -3 0.758
TSSK1TSSK1 0.750 0.171 -3 0.793
MOSMOS 0.750 0.094 1 0.794
SRPK1SRPK1 0.750 0.083 -3 0.686
PRPKPRPK 0.750 -0.019 -1 0.672
CAMK2BCAMK2B 0.750 0.139 2 0.721
CLK2CLK2 0.749 0.141 -3 0.728
CLK1CLK1 0.749 0.145 -3 0.739
SRPK2SRPK2 0.749 0.091 -3 0.631
AMPKA1AMPKA1 0.749 0.115 -3 0.788
PRKD3PRKD3 0.748 0.151 -3 0.730
CDKL1CDKL1 0.748 0.046 -3 0.694
KISKIS 0.748 0.078 1 0.607
AMPKA2AMPKA2 0.748 0.116 -3 0.781
NDR2NDR2 0.748 0.029 -3 0.746
CAMK2ACAMK2A 0.747 0.129 2 0.738
BMPR1BBMPR1B 0.746 0.176 1 0.728
PKN3PKN3 0.746 0.046 -3 0.731
LATS2LATS2 0.746 0.050 -5 0.499
CAMK2DCAMK2D 0.745 0.085 -3 0.741
CLK4CLK4 0.745 0.100 -3 0.726
RAF1RAF1 0.745 -0.022 1 0.674
SKMLCKSKMLCK 0.745 0.057 -2 0.653
DSTYKDSTYK 0.744 -0.030 2 0.797
BMPR2BMPR2 0.744 -0.022 -2 0.726
MTORMTOR 0.743 -0.064 1 0.632
NIKNIK 0.743 0.069 -3 0.764
FAM20CFAM20C 0.743 0.071 2 0.560
ATRATR 0.742 -0.010 1 0.699
ERK5ERK5 0.742 0.010 1 0.689
NLKNLK 0.742 0.009 1 0.696
RSK2RSK2 0.741 0.034 -3 0.712
MARK4MARK4 0.741 0.036 4 0.710
DAPK2DAPK2 0.741 0.063 -3 0.740
ATMATM 0.741 0.036 1 0.663
MELKMELK 0.741 0.108 -3 0.768
CAMK2GCAMK2G 0.740 -0.040 2 0.752
P90RSKP90RSK 0.740 0.035 -3 0.693
CAMK4CAMK4 0.740 0.063 -3 0.772
CDKL5CDKL5 0.739 0.020 -3 0.690
CHAK2CHAK2 0.739 0.044 -1 0.683
TBK1TBK1 0.739 -0.078 1 0.541
HIPK4HIPK4 0.739 0.043 1 0.672
PDHK4PDHK4 0.738 -0.184 1 0.684
IKKBIKKB 0.738 -0.097 -2 0.573
TGFBR1TGFBR1 0.738 0.114 -2 0.739
WNK1WNK1 0.738 0.019 -2 0.668
LATS1LATS1 0.738 0.067 -3 0.717
SIKSIK 0.737 0.089 -3 0.731
PKN2PKN2 0.737 0.032 -3 0.778
NDR1NDR1 0.737 -0.001 -3 0.759
IKKAIKKA 0.737 -0.021 -2 0.582
CAMLCKCAMLCK 0.737 -0.001 -2 0.639
TGFBR2TGFBR2 0.736 0.011 -2 0.712
GRK6GRK6 0.735 0.001 1 0.705
ALK4ALK4 0.735 0.097 -2 0.746
ICKICK 0.735 0.018 -3 0.717
JNK2JNK2 0.735 0.099 1 0.549
GCN2GCN2 0.735 -0.130 2 0.709
ALK2ALK2 0.735 0.167 -2 0.720
P70S6KBP70S6KB 0.735 0.027 -3 0.740
BMPR1ABMPR1A 0.735 0.187 1 0.726
PKCDPKCD 0.735 0.028 2 0.727
DCAMKL1DCAMKL1 0.735 0.112 -3 0.782
SRPK3SRPK3 0.735 0.047 -3 0.648
CAMK1DCAMK1D 0.734 0.122 -3 0.707
ACVR2BACVR2B 0.734 0.116 -2 0.730
CDK8CDK8 0.734 0.032 1 0.580
NEK6NEK6 0.733 -0.063 -2 0.722
MSK2MSK2 0.733 0.014 -3 0.673
CDK18CDK18 0.733 0.058 1 0.561
HUNKHUNK 0.733 -0.085 2 0.742
DYRK2DYRK2 0.732 0.056 1 0.581
ULK2ULK2 0.732 -0.143 2 0.715
QSKQSK 0.732 0.050 4 0.675
MNK2MNK2 0.732 0.038 -2 0.584
RSK3RSK3 0.732 0.007 -3 0.711
GRK5GRK5 0.732 -0.088 -3 0.662
PRKXPRKX 0.731 0.068 -3 0.710
ACVR2AACVR2A 0.731 0.084 -2 0.723
JNK3JNK3 0.731 0.077 1 0.586
MSK1MSK1 0.731 0.024 -3 0.698
IKKEIKKE 0.731 -0.118 1 0.533
PKACBPKACB 0.730 0.038 -2 0.459
CDK19CDK19 0.730 0.035 1 0.549
NEK7NEK7 0.730 -0.127 -3 0.598
P38AP38A 0.729 0.055 1 0.617
MYLK4MYLK4 0.729 0.023 -2 0.557
PDHK1PDHK1 0.729 -0.196 1 0.656
MST4MST4 0.729 -0.028 2 0.742
GRK7GRK7 0.728 0.022 1 0.671
BRSK1BRSK1 0.728 0.030 -3 0.756
DCAMKL2DCAMKL2 0.728 0.091 -3 0.790
MARK3MARK3 0.728 0.045 4 0.650
CDK5CDK5 0.728 0.047 1 0.635
CAMK1GCAMK1G 0.728 0.045 -3 0.714
NIM1NIM1 0.728 -0.036 3 0.679
AURCAURC 0.728 -0.001 -2 0.439
CDK1CDK1 0.727 0.041 1 0.579
MARK2MARK2 0.727 0.031 4 0.612
QIKQIK 0.727 -0.000 -3 0.735
DNAPKDNAPK 0.727 0.031 1 0.571
CDK7CDK7 0.727 0.023 1 0.610
AKT2AKT2 0.726 0.047 -3 0.682
MNK1MNK1 0.726 0.036 -2 0.591
WNK3WNK3 0.726 -0.146 1 0.635
PKACGPKACG 0.726 -0.031 -2 0.499
DLKDLK 0.726 -0.111 1 0.636
MAPKAPK5MAPKAPK5 0.725 0.013 -3 0.645
CAMK1ACAMK1A 0.725 0.121 -3 0.698
RIPK3RIPK3 0.725 -0.129 3 0.646
ULK1ULK1 0.725 -0.135 -3 0.604
SSTKSSTK 0.725 0.079 4 0.676
P38BP38B 0.725 0.047 1 0.568
NEK9NEK9 0.725 -0.108 2 0.739
SBKSBK 0.725 0.109 -3 0.612
CDK2CDK2 0.725 0.023 1 0.628
BRSK2BRSK2 0.725 0.014 -3 0.770
PKCBPKCB 0.724 0.007 2 0.669
RSK4RSK4 0.724 0.019 -3 0.683
PLK1PLK1 0.724 -0.060 -2 0.682
P38GP38G 0.724 0.053 1 0.498
CDK16CDK16 0.724 0.065 1 0.543
HIPK2HIPK2 0.724 0.069 1 0.522
PHKG1PHKG1 0.724 0.012 -3 0.767
MASTLMASTL 0.724 -0.191 -2 0.619
MLK1MLK1 0.724 -0.153 2 0.724
DYRK1ADYRK1A 0.723 0.048 1 0.638
PIM2PIM2 0.723 0.034 -3 0.713
CDK17CDK17 0.723 0.037 1 0.516
PAK1PAK1 0.723 -0.026 -2 0.563
BCKDKBCKDK 0.723 -0.080 -1 0.730
CHK2CHK2 0.723 0.103 -3 0.675
GRK1GRK1 0.723 -0.041 -2 0.552
SMG1SMG1 0.723 -0.016 1 0.656
IRE2IRE2 0.723 -0.055 2 0.707
CDK13CDK13 0.722 0.012 1 0.588
MLK2MLK2 0.722 -0.096 2 0.733
MARK1MARK1 0.722 0.019 4 0.679
P38DP38D 0.722 0.070 1 0.524
ANKRD3ANKRD3 0.721 -0.143 1 0.648
GRK4GRK4 0.721 -0.107 -2 0.639
PAK3PAK3 0.721 -0.044 -2 0.571
IRE1IRE1 0.720 -0.090 1 0.625
HIPK1HIPK1 0.720 0.052 1 0.598
CDK3CDK3 0.720 0.055 1 0.537
PKRPKR 0.720 -0.058 1 0.674
BRAFBRAF 0.720 0.022 -4 0.747
ERK1ERK1 0.720 0.025 1 0.556
SGK3SGK3 0.720 0.020 -3 0.740
DYRK4DYRK4 0.719 0.059 1 0.537
PKACAPKACA 0.719 0.025 -2 0.421
MEK1MEK1 0.718 -0.115 2 0.771
PAK6PAK6 0.718 0.017 -2 0.492
PKCZPKCZ 0.718 -0.038 2 0.695
DAPK3DAPK3 0.718 0.069 -3 0.755
AURBAURB 0.718 -0.026 -2 0.436
ERK2ERK2 0.718 0.004 1 0.599
PASKPASK 0.717 0.030 -3 0.720
RIPK1RIPK1 0.717 -0.172 1 0.609
PLK3PLK3 0.717 -0.066 2 0.706
TLK2TLK2 0.717 -0.046 1 0.634
YSK4YSK4 0.717 -0.095 1 0.579
AKT1AKT1 0.716 0.039 -3 0.708
PKG2PKG2 0.716 -0.015 -2 0.449
PINK1PINK1 0.716 -0.087 1 0.718
HIPK3HIPK3 0.715 0.052 1 0.577
CDK14CDK14 0.715 0.031 1 0.584
PRP4PRP4 0.715 0.009 -3 0.605
DYRK1BDYRK1B 0.715 0.040 1 0.565
PHKG2PHKG2 0.715 0.033 -3 0.793
CDK9CDK9 0.715 0.005 1 0.587
PKCHPKCH 0.715 -0.043 2 0.657
SMMLCKSMMLCK 0.714 -0.002 -3 0.735
CHAK1CHAK1 0.714 -0.085 2 0.658
HRIHRI 0.714 -0.079 -2 0.726
TLK1TLK1 0.713 -0.029 -2 0.729
PKCGPKCG 0.713 -0.057 2 0.660
CDK12CDK12 0.713 0.003 1 0.558
MLK3MLK3 0.713 -0.101 2 0.659
VRK2VRK2 0.713 -0.210 1 0.691
PAK2PAK2 0.712 -0.078 -2 0.539
PKCAPKCA 0.711 -0.057 2 0.658
DRAK1DRAK1 0.711 -0.083 1 0.590
GRK2GRK2 0.711 -0.083 -2 0.546
AURAAURA 0.711 -0.043 -2 0.420
DAPK1DAPK1 0.711 0.040 -3 0.734
NEK2NEK2 0.710 -0.122 2 0.713
DYRK3DYRK3 0.710 0.016 1 0.577
GSK3AGSK3A 0.710 -0.003 4 0.408
TTBK2TTBK2 0.710 -0.177 2 0.597
NEK5NEK5 0.710 -0.063 1 0.653
SNRKSNRK 0.710 -0.097 2 0.631
BUB1BUB1 0.709 0.130 -5 0.717
TAO3TAO3 0.709 -0.011 1 0.606
JNK1JNK1 0.708 0.041 1 0.559
CK2A2CK2A2 0.708 0.031 1 0.651
CDK10CDK10 0.708 0.031 1 0.575
P70S6KP70S6K 0.707 -0.021 -3 0.672
IRAK4IRAK4 0.707 -0.076 1 0.620
PKN1PKN1 0.706 0.027 -3 0.704
PERKPERK 0.706 -0.115 -2 0.707
GSK3BGSK3B 0.706 -0.026 4 0.394
MLK4MLK4 0.706 -0.127 2 0.639
GAKGAK 0.705 0.001 1 0.722
CK1ECK1E 0.705 -0.060 -3 0.402
SGK1SGK1 0.704 0.028 -3 0.623
WNK4WNK4 0.704 -0.102 -2 0.663
PKCTPKCT 0.704 -0.046 2 0.667
MRCKAMRCKA 0.704 0.026 -3 0.735
PLK4PLK4 0.703 -0.119 2 0.580
MEKK2MEKK2 0.703 -0.132 2 0.728
MEKK3MEKK3 0.703 -0.179 1 0.584
TAO2TAO2 0.702 -0.037 2 0.771
MEK5MEK5 0.702 -0.224 2 0.745
ZAKZAK 0.702 -0.150 1 0.552
AKT3AKT3 0.701 0.017 -3 0.637
MRCKBMRCKB 0.701 0.023 -3 0.736
EEF2KEEF2K 0.701 -0.002 3 0.746
MEKK1MEKK1 0.700 -0.183 1 0.597
CDK6CDK6 0.700 0.021 1 0.566
CDK4CDK4 0.700 0.020 1 0.555
GCKGCK 0.699 -0.018 1 0.614
MPSK1MPSK1 0.699 -0.049 1 0.661
DMPK1DMPK1 0.699 0.062 -3 0.767
MST2MST2 0.699 -0.055 1 0.616
ERK7ERK7 0.699 -0.022 2 0.445
MST3MST3 0.699 -0.086 2 0.732
ROCK2ROCK2 0.698 0.025 -3 0.758
PDK1PDK1 0.697 -0.064 1 0.612
MAKMAK 0.697 0.023 -2 0.527
CK1DCK1D 0.697 -0.070 -3 0.360
PKCIPKCI 0.696 -0.065 2 0.661
CAMKK1CAMKK1 0.696 -0.155 -2 0.572
PAK5PAK5 0.696 -0.041 -2 0.421
CK2A1CK2A1 0.696 -0.000 1 0.619
PKCEPKCE 0.696 -0.026 2 0.644
LKB1LKB1 0.696 -0.103 -3 0.649
NEK8NEK8 0.696 -0.165 2 0.733
TNIKTNIK 0.695 -0.019 3 0.775
GRK3GRK3 0.695 -0.089 -2 0.508
PLK2PLK2 0.695 -0.038 -3 0.616
NEK11NEK11 0.693 -0.157 1 0.585
IRAK1IRAK1 0.693 -0.176 -1 0.565
HGKHGK 0.692 -0.066 3 0.772
MOKMOK 0.692 0.010 1 0.609
LRRK2LRRK2 0.692 -0.105 2 0.751
NEK1NEK1 0.691 -0.078 1 0.612
TAK1TAK1 0.691 -0.093 1 0.673
CAMKK2CAMKK2 0.691 -0.160 -2 0.566
NEK4NEK4 0.690 -0.138 1 0.597
KHS1KHS1 0.690 -0.006 1 0.588
MEKK6MEKK6 0.690 -0.097 1 0.597
TTKTTK 0.690 0.006 -2 0.698
KHS2KHS2 0.690 0.004 1 0.606
MINKMINK 0.690 -0.082 1 0.594
HPK1HPK1 0.690 -0.053 1 0.591
PBKPBK 0.690 -0.002 1 0.653
CK1A2CK1A2 0.689 -0.082 -3 0.372
SLKSLK 0.689 -0.057 -2 0.502
PAK4PAK4 0.689 -0.049 -2 0.430
CK1G1CK1G1 0.689 -0.100 -3 0.387
ROCK1ROCK1 0.689 0.017 -3 0.747
MAP3K15MAP3K15 0.689 -0.089 1 0.546
MST1MST1 0.688 -0.080 1 0.591
LOKLOK 0.688 -0.075 -2 0.561
CRIKCRIK 0.687 0.014 -3 0.689
BIKEBIKE 0.687 0.045 1 0.627
VRK1VRK1 0.686 -0.117 2 0.790
PDHK3_TYRPDHK3_TYR 0.685 0.074 4 0.783
PKG1PKG1 0.684 -0.036 -2 0.395
ALPHAK3ALPHAK3 0.684 0.008 -1 0.585
TTBK1TTBK1 0.683 -0.179 2 0.534
PDHK4_TYRPDHK4_TYR 0.680 0.016 2 0.804
AAK1AAK1 0.680 0.079 1 0.553
MAP2K6_TYRMAP2K6_TYR 0.680 -0.006 -1 0.705
HASPINHASPIN 0.678 -0.033 -1 0.480
MAP2K4_TYRMAP2K4_TYR 0.677 -0.057 -1 0.699
MEK2MEK2 0.677 -0.216 2 0.733
RIPK2RIPK2 0.676 -0.221 1 0.509
TESK1_TYRTESK1_TYR 0.676 -0.047 3 0.776
PDHK1_TYRPDHK1_TYR 0.675 -0.017 -1 0.704
YSK1YSK1 0.674 -0.129 2 0.706
OSR1OSR1 0.674 -0.097 2 0.714
EPHB4EPHB4 0.672 0.076 -1 0.703
LIMK2_TYRLIMK2_TYR 0.670 -0.036 -3 0.746
MAP2K7_TYRMAP2K7_TYR 0.670 -0.205 2 0.780
STK33STK33 0.670 -0.189 2 0.537
TAO1TAO1 0.669 -0.077 1 0.513
NEK3NEK3 0.669 -0.180 1 0.541
PINK1_TYRPINK1_TYR 0.669 -0.149 1 0.687
INSRRINSRR 0.668 -0.007 3 0.671
MYO3BMYO3B 0.668 -0.091 2 0.723
TYRO3TYRO3 0.667 -0.038 3 0.721
FERFER 0.667 0.010 1 0.766
PKMYT1_TYRPKMYT1_TYR 0.667 -0.146 3 0.749
EPHA6EPHA6 0.667 0.023 -1 0.672
ROS1ROS1 0.667 -0.035 3 0.704
BMPR2_TYRBMPR2_TYR 0.666 -0.123 -1 0.650
EPHB3EPHB3 0.665 0.079 -1 0.703
ASK1ASK1 0.665 -0.140 1 0.541
ABL2ABL2 0.665 -0.011 -1 0.647
EPHB2EPHB2 0.665 0.086 -1 0.680
EPHA4EPHA4 0.665 0.048 2 0.710
YES1YES1 0.665 -0.027 -1 0.660
RETRET 0.664 -0.096 1 0.612
TXKTXK 0.664 0.035 1 0.696
DDR1DDR1 0.664 -0.063 4 0.718
MYO3AMYO3A 0.664 -0.110 1 0.584
LIMK1_TYRLIMK1_TYR 0.663 -0.142 2 0.773
EPHB1EPHB1 0.663 0.047 1 0.689
CSF1RCSF1R 0.662 -0.081 3 0.716
SRMSSRMS 0.662 0.017 1 0.725
CK1ACK1A 0.660 -0.090 -3 0.285
ABL1ABL1 0.660 -0.029 -1 0.637
MST1RMST1R 0.659 -0.127 3 0.727
TYK2TYK2 0.659 -0.158 1 0.613
BLKBLK 0.658 0.011 -1 0.625
TNK2TNK2 0.658 -0.036 3 0.695
FGRFGR 0.658 -0.108 1 0.697
YANK3YANK3 0.657 -0.101 2 0.340
JAK2JAK2 0.656 -0.147 1 0.603
TEKTEK 0.656 -0.048 3 0.670
HCKHCK 0.655 -0.061 -1 0.612
EPHA5EPHA5 0.655 0.056 2 0.710
JAK3JAK3 0.655 -0.123 1 0.590
LCKLCK 0.654 -0.037 -1 0.600
DDR2DDR2 0.654 -0.009 3 0.671
STLK3STLK3 0.654 -0.169 1 0.528
TECTEC 0.654 -0.006 -1 0.583
AXLAXL 0.653 -0.060 3 0.688
FGFR2FGFR2 0.653 -0.118 3 0.700
FLT3FLT3 0.653 -0.103 3 0.725
MERTKMERTK 0.653 -0.043 3 0.692
KITKIT 0.652 -0.113 3 0.712
ALKALK 0.652 -0.048 3 0.668
ITKITK 0.652 -0.058 -1 0.600
BMXBMX 0.652 -0.025 -1 0.541
TNK1TNK1 0.652 -0.078 3 0.701
LTKLTK 0.651 -0.046 3 0.680
EPHA7EPHA7 0.651 0.004 2 0.714
PDGFRBPDGFRB 0.650 -0.136 3 0.725
FGFR1FGFR1 0.650 -0.122 3 0.688
EPHA3EPHA3 0.650 -0.042 2 0.686
PTK2BPTK2B 0.649 -0.011 -1 0.615
TNNI3K_TYRTNNI3K_TYR 0.649 -0.080 1 0.591
NEK10_TYRNEK10_TYR 0.649 -0.119 1 0.534
KDRKDR 0.649 -0.132 3 0.684
FRKFRK 0.648 -0.027 -1 0.653
FYNFYN 0.647 -0.044 -1 0.563
BTKBTK 0.647 -0.093 -1 0.588
METMET 0.646 -0.122 3 0.710
NTRK1NTRK1 0.646 -0.115 -1 0.681
INSRINSR 0.646 -0.094 3 0.652
CK1G3CK1G3 0.646 -0.091 -3 0.251
PDGFRAPDGFRA 0.646 -0.149 3 0.720
EPHA1EPHA1 0.644 -0.051 3 0.703
FGFR3FGFR3 0.644 -0.130 3 0.676
EPHA8EPHA8 0.643 -0.029 -1 0.648
JAK1JAK1 0.643 -0.125 1 0.524
PTK6PTK6 0.642 -0.132 -1 0.558
NTRK3NTRK3 0.641 -0.099 -1 0.655
LYNLYN 0.641 -0.076 3 0.637
MATKMATK 0.639 -0.113 -1 0.587
NTRK2NTRK2 0.639 -0.158 3 0.654
SRCSRC 0.637 -0.080 -1 0.588
ERBB2ERBB2 0.637 -0.162 1 0.593
SYKSYK 0.637 -0.027 -1 0.555
FLT1FLT1 0.637 -0.171 -1 0.635
FLT4FLT4 0.637 -0.164 3 0.659
WEE1_TYRWEE1_TYR 0.636 -0.146 -1 0.566
CSKCSK 0.635 -0.109 2 0.712
EGFREGFR 0.635 -0.090 1 0.510
EPHA2EPHA2 0.635 -0.041 -1 0.601
FGFR4FGFR4 0.633 -0.110 -1 0.603
PTK2PTK2 0.632 -0.074 -1 0.541
IGF1RIGF1R 0.630 -0.115 3 0.592
MUSKMUSK 0.629 -0.084 1 0.500
ERBB4ERBB4 0.628 -0.072 1 0.554
CK1G2CK1G2 0.626 -0.101 -3 0.326
YANK2YANK2 0.625 -0.127 2 0.363
FESFES 0.616 -0.107 -1 0.517
ZAP70ZAP70 0.614 -0.085 -1 0.492