Motif 686 (n=106)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00592 | PODXL | T518 | ochoa | Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) | Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}. |
| O14974 | PPP1R12A | T884 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O43683 | BUB1 | T173 | psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43815 | STRN | T123 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O43896 | KIF1C | T489 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| O60271 | SPAG9 | T418 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60333 | KIF1B | T522 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O60503 | ADCY9 | T690 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60664 | PLIN3 | T191 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O75436 | VPS26A | T307 | ochoa | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250|UniProtKB:P40336, ECO:0000269|PubMed:15078902, ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:22279231, ECO:0000303|PubMed:20923837, ECO:0000303|PubMed:21602791, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491, ECO:0000305}. |
| O95999 | BCL10 | T52 | psp | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). {ECO:0000269|PubMed:10187770, ECO:0000269|PubMed:10187815, ECO:0000269|PubMed:10364242, ECO:0000269|PubMed:10400625, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:25365219, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:27777308}. |
| O96017 | CHEK2 | T389 | ochoa|psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P05090 | APOD | T168 | ochoa | Apolipoprotein D (Apo-D) (ApoD) | APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts. |
| P05412 | JUN | T93 | ochoa|psp | Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) | Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000250|UniProtKB:P05627, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. {ECO:0000269|PubMed:31341047}. |
| P05546 | SERPIND1 | T64 | ochoa | Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1) | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. {ECO:0000269|PubMed:1939083, ECO:0000269|PubMed:32827448}.; FUNCTION: Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. {ECO:0000269|PubMed:1939083}.; FUNCTION: [Isoform 2]: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro. {ECO:0000269|PubMed:32827448}. |
| P06239 | LCK | T147 | ochoa | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P06733 | ENO1 | T26 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P08238 | HSP90AB1 | T89 | psp | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | T459 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P10114 | RAP2A | T61 | ochoa | Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30) | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK (PubMed:14966141, PubMed:15342639, PubMed:18930710, PubMed:20159449). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (PubMed:20159449). More generally, it is part of several signaling cascades and regulates cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). {ECO:0000269|PubMed:14966141, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:16246175, ECO:0000269|PubMed:16540189, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:35293963}. |
| P11055 | MYH3 | S1367 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11137 | MAP2 | T522 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11142 | HSPA8 | T418 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P12882 | MYH1 | T1278 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1370 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | T1725 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | T1274 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1366 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T1721 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1368 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | T1723 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | T1277 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13535 | MYH8 | S1369 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13535 | MYH8 | T1724 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P20700 | LMNB1 | T283 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P22626 | HNRNPA2B1 | T176 | ochoa|psp | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P26045 | PTPN3 | T326 | ochoa | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
| P34932 | HSPA4 | T551 | ochoa | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P35221 | CTNNA1 | T42 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P45880 | VDAC2 | T113 | ochoa | Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P54652 | HSPA2 | T421 | ochoa | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| P61225 | RAP2B | T61 | ochoa | Ras-related protein Rap-2b (EC 3.6.5.2) | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. {ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:15143162, ECO:0000269|PubMed:16540189}. |
| P63244 | RACK1 | T50 | psp | Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}. |
| Q12756 | KIF1A | T482 | ochoa | Kinesin-like protein KIF1A (EC 5.6.1.3) (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:33880452}. |
| Q12802 | AKAP13 | T2411 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12834 | CDC20 | T108 | ochoa | Cell division cycle protein 20 homolog (p55CDC) | Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
| Q12929 | EPS8 | T699 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13007 | IL24 | T111 | psp | Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein) | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity). {ECO:0000250|UniProtKB:Q925S4, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:25168428, ECO:0000269|PubMed:27687232, ECO:0000269|PubMed:30111632}. |
| Q13206 | DDX10 | T610 | ochoa | Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) | Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599). {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:36779599}. |
| Q13416 | ORC2 | T258 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q14680 | MELK | T539 | psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q14684 | RRP1B | T627 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q15025 | TNIP1 | T406 | ochoa | TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) | Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814, ECO:0000269|PubMed:21885437}. |
| Q15121 | PEA15 | T100 | ochoa | Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED) | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. {ECO:0000250, ECO:0000269|PubMed:10442631, ECO:0000269|PubMed:9670003}. |
| Q5T7B8 | KIF24 | T494 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5THJ4 | VPS13D | T1743 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VST9 | OBSCN | T745 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VZ89 | DENND4C | T1209 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q6P0N0 | MIS18BP1 | T147 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6PKG0 | LARP1 | T622 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6ZMQ8 | AATK | T981 | ochoa | Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) | May be involved in neuronal differentiation. {ECO:0000269|PubMed:10837911}. |
| Q86UP2 | KTN1 | T107 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q8N1F7 | NUP93 | T51 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8NEM2 | SHCBP1 | T623 | ochoa | SHC SH2 domain-binding protein 1 | May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000250|UniProtKB:Q9Z179}. |
| Q8TDN4 | CABLES1 | T309 | psp | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}. |
| Q8TEQ6 | GEMIN5 | T853 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8WYK0 | ACOT12 | T153 | ochoa | Acetyl-coenzyme A thioesterase (EC 3.1.2.1) (Acyl-CoA thioester hydrolase 12) (Acyl-coenzyme A thioesterase 12) (Acyl-CoA thioesterase 12) (Cytoplasmic acetyl-CoA hydrolase 1) (CACH-1) (hCACH-1) (START domain-containing protein 15) (StARD15) | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16951743). Preferentially hydrolyzes acetyl-CoA (PubMed:16951743). {ECO:0000269|PubMed:16951743}. |
| Q96JZ2 | HSH2D | T187 | ochoa | Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) | May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}. |
| Q96QT4 | TRPM7 | T1685 | psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q99814 | EPAS1 | T324 | psp | Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2) | Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97481}. |
| Q9C0C9 | UBE2O | T838 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9H2G2 | SLK | T441 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H5I5 | PIEZO2 | T1879 | ochoa | Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}. |
| Q9NYF8 | BCLAF1 | T355 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZQ7 | CD274 | T180 | psp | Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274) | Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201). {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417, ECO:0000269|PubMed:31399419, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:36727298}.; FUNCTION: The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813410, PubMed:28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity). {ECO:0000250|UniProtKB:Q9EP73, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}. |
| Q9UBU9 | NXF1 | T576 | ochoa | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}. |
| Q9UHP3 | USP25 | T680 | psp | Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) | Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response (PubMed:29518389, PubMed:37683630). Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2 (PubMed:28619731, PubMed:30926243, PubMed:38875478). Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program (PubMed:37339955). Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2 (PubMed:37683630). In turn, restricts virus production by regulating cholesterol biosynthetic flux (PubMed:37683630). Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6 (PubMed:23042150). Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance (PubMed:30579117). {ECO:0000269|PubMed:23042150, ECO:0000269|PubMed:28619731, ECO:0000269|PubMed:29518389, ECO:0000269|PubMed:30579117, ECO:0000269|PubMed:30926243, ECO:0000269|PubMed:37339955, ECO:0000269|PubMed:37683630, ECO:0000269|PubMed:38875478}.; FUNCTION: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function. |
| Q9UKX2 | MYH2 | T1280 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T1372 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T1727 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S1370 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9Y2X9 | ZNF281 | T399 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y3L5 | RAP2C | T61 | ochoa | Ras-related protein Rap-2c (EC 3.6.5.2) | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. {ECO:0000269|PubMed:17447155}. |
| Q9Y496 | KIF3A | T672 | psp | Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) | Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. {ECO:0000250|UniProtKB:P28741}. |
| Q9Y623 | MYH4 | S1370 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y623 | MYH4 | T1725 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6Y8 | SEC23IP | T893 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| P13929 | ENO3 | T26 | Sugiyama | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| Q14444 | CAPRIN1 | T303 | Sugiyama | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}. |
| P62081 | RPS7 | T172 | Sugiyama | Small ribosomal subunit protein eS7 (40S ribosomal protein S7) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for rRNA maturation (PubMed:19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P07900 | HSP90AA1 | T467 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P39687 | ANP32A | T143 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}. |
| O75582 | RPS6KA5 | T718 | Sugiyama | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| P50990 | CCT8 | T424 | Sugiyama | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P53985 | SLC16A1 | T231 | Sugiyama | Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1) | Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023). {ECO:0000250|UniProtKB:P53986, ECO:0000250|UniProtKB:P53987, ECO:0000269|PubMed:12946269, ECO:0000269|PubMed:32946811, ECO:0000269|PubMed:33333023}. |
| P35579 | MYH9 | T873 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P32929 | CTH | T355 | SIGNOR | Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2) | Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (PubMed:10212249, PubMed:18476726, PubMed:19261609, PubMed:19961860). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione (PubMed:18476726). Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce the endogenous gaseous signaling molecule hydrogen sulfide (H2S) (PubMed:10212249, PubMed:19019829, PubMed:19261609, PubMed:19961860). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, also two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia (which is a risk factor for cardiovascular disease, diabetes, and Alzheimer's disease) (PubMed:19261609). Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively (PubMed:19261609). Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (PubMed:22169477). By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (Probable) (PubMed:29254196). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity). {ECO:0000250|UniProtKB:P18757, ECO:0000250|UniProtKB:Q8VCN5, ECO:0000269|PubMed:10212249, ECO:0000269|PubMed:18476726, ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:19961860, ECO:0000269|PubMed:22169477, ECO:0000269|PubMed:29254196, ECO:0000303|PubMed:18476726, ECO:0000305|PubMed:18476726, ECO:0000305|PubMed:19019829}. |
| Q00534 | CDK6 | T70 | Sugiyama | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| O15212 | PFDN6 | T38 | Sugiyama | Prefoldin subunit 6 (Protein Ke2) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q14289 | PTK2B | T149 | Sugiyama | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q7RTN6 | STRADA | T38 | Sugiyama | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}. |
| P07900 | HSP90AA1 | T94 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| Q58FG1 | HSP90AA4P | T34 | Sugiyama | Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q16566 | CAMK4 | T57 | Sugiyama | Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}. |
| P26232 | CTNNA2 | T41 | Sugiyama | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P48454 | PPP3CC | T157 | Sugiyama | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform) | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. {ECO:0000269|PubMed:19154138}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.000018 | 4.735 |
| R-HSA-3371568 | Attenuation phase | 0.000284 | 3.546 |
| R-HSA-3371556 | Cellular response to heat stress | 0.000290 | 3.538 |
| R-HSA-1640170 | Cell Cycle | 0.000316 | 3.501 |
| R-HSA-449147 | Signaling by Interleukins | 0.000337 | 3.472 |
| R-HSA-9663891 | Selective autophagy | 0.000485 | 3.314 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000503 | 3.298 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.000665 | 3.177 |
| R-HSA-162582 | Signal Transduction | 0.000864 | 3.064 |
| R-HSA-9612973 | Autophagy | 0.001081 | 2.966 |
| R-HSA-983189 | Kinesins | 0.001121 | 2.950 |
| R-HSA-525793 | Myogenesis | 0.001299 | 2.886 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.001526 | 2.816 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.001453 | 2.838 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.001681 | 2.774 |
| R-HSA-168256 | Immune System | 0.001732 | 2.761 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.002056 | 2.687 |
| R-HSA-390522 | Striated Muscle Contraction | 0.002443 | 2.612 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.002410 | 2.618 |
| R-HSA-9613354 | Lipophagy | 0.002935 | 2.532 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.002935 | 2.532 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.003393 | 2.469 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.003430 | 2.465 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.003612 | 2.442 |
| R-HSA-1632852 | Macroautophagy | 0.004064 | 2.391 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.003961 | 2.402 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.003873 | 2.412 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.005659 | 2.247 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.005454 | 2.263 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.006149 | 2.211 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.006832 | 2.165 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.007142 | 2.146 |
| R-HSA-111885 | Opioid Signalling | 0.007256 | 2.139 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.007142 | 2.146 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.008650 | 2.063 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.008650 | 2.063 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.008859 | 2.053 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.009431 | 2.025 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.010095 | 1.996 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 0.013080 | 1.883 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 0.019556 | 1.709 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 0.019556 | 1.709 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 0.019556 | 1.709 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.025990 | 1.585 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.025990 | 1.585 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.025990 | 1.585 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.025990 | 1.585 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.025990 | 1.585 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.025990 | 1.585 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.025990 | 1.585 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.025990 | 1.585 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.025990 | 1.585 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.025990 | 1.585 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.025990 | 1.585 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.032382 | 1.490 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.038733 | 1.412 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.045042 | 1.346 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.051311 | 1.290 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.051311 | 1.290 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.057538 | 1.240 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 0.057538 | 1.240 |
| R-HSA-8849473 | PTK6 Expression | 0.063726 | 1.196 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.063726 | 1.196 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.069873 | 1.156 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.075979 | 1.119 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.012052 | 1.919 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.012981 | 1.887 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.082047 | 1.086 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.082047 | 1.086 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.015945 | 1.797 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.094063 | 1.027 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.094063 | 1.027 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.100012 | 1.000 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.105923 | 0.975 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.105923 | 0.975 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.022642 | 1.645 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.025090 | 1.600 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.117630 | 0.929 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.117630 | 0.929 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.117630 | 0.929 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.027642 | 1.558 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.028955 | 1.538 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.134906 | 0.870 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.134906 | 0.870 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.037337 | 1.428 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.038815 | 1.411 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.146236 | 0.835 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.146236 | 0.835 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.157420 | 0.803 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.157420 | 0.803 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.157420 | 0.803 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.059904 | 1.223 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.061659 | 1.210 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.024593 | 1.609 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.024593 | 1.609 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.065222 | 1.186 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.072549 | 1.139 |
| R-HSA-191859 | snRNP Assembly | 0.072549 | 1.139 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.037414 | 1.427 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.100062 | 1.000 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.119041 | 0.924 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.161574 | 0.792 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.138828 | 0.858 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.094063 | 1.027 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.129185 | 0.889 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.067030 | 1.174 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.132152 | 0.879 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.105923 | 0.975 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.094063 | 1.027 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.135456 | 0.868 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.038733 | 1.412 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.075979 | 1.119 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.095971 | 1.018 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.095971 | 1.018 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.078211 | 1.107 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.119095 | 0.924 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.051311 | 1.290 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.069873 | 1.156 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.075979 | 1.119 |
| R-HSA-391251 | Protein folding | 0.145576 | 0.837 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.019556 | 1.709 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 0.019556 | 1.709 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 0.019556 | 1.709 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 0.038733 | 1.412 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.051311 | 1.290 |
| R-HSA-199920 | CREB phosphorylation | 0.057538 | 1.240 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 0.063726 | 1.196 |
| R-HSA-192905 | vRNP Assembly | 0.088074 | 1.055 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.100012 | 1.000 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.105923 | 0.975 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.105923 | 0.975 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.111796 | 0.952 |
| R-HSA-804914 | Transport of fatty acids | 0.111796 | 0.952 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.140589 | 0.852 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.150112 | 0.824 |
| R-HSA-6798695 | Neutrophil degranulation | 0.096300 | 1.016 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.040314 | 1.395 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.082047 | 1.086 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.022642 | 1.645 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.068853 | 1.162 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.047208 | 1.326 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.042613 | 1.370 |
| R-HSA-3371511 | HSF1 activation | 0.033041 | 1.481 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.047208 | 1.326 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.123374 | 0.909 |
| R-HSA-202424 | Downstream TCR signaling | 0.138828 | 0.858 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.082047 | 1.086 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.151846 | 0.819 |
| R-HSA-112040 | G-protein mediated events | 0.087941 | 1.056 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.068853 | 1.162 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.111796 | 0.952 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.106548 | 0.972 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.019556 | 1.709 |
| R-HSA-9675132 | Diseases of cellular response to stress | 0.025990 | 1.585 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 0.025990 | 1.585 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.088074 | 1.055 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.134906 | 0.870 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.140589 | 0.852 |
| R-HSA-1221632 | Meiotic synapsis | 0.061659 | 1.210 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.063432 | 1.198 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.093944 | 1.027 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.156970 | 0.804 |
| R-HSA-68877 | Mitotic Prometaphase | 0.052026 | 1.284 |
| R-HSA-1280218 | Adaptive Immune System | 0.092873 | 1.032 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.060240 | 1.220 |
| R-HSA-111933 | Calmodulin induced events | 0.033041 | 1.481 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.097176 | 1.012 |
| R-HSA-5617833 | Cilium Assembly | 0.049866 | 1.302 |
| R-HSA-111997 | CaM pathway | 0.033041 | 1.481 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.075979 | 1.119 |
| R-HSA-198753 | ERK/MAPK targets | 0.157420 | 0.803 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.161274 | 0.792 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.037200 | 1.429 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.140589 | 0.852 |
| R-HSA-111996 | Ca-dependent events | 0.043378 | 1.363 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.054033 | 1.267 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.038733 | 1.412 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.117630 | 0.929 |
| R-HSA-163615 | PKA activation | 0.140589 | 0.852 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.146236 | 0.835 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.048130 | 1.318 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.162957 | 0.788 |
| R-HSA-68882 | Mitotic Anaphase | 0.020286 | 1.693 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.020615 | 1.686 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.130687 | 0.884 |
| R-HSA-194138 | Signaling by VEGF | 0.065657 | 1.183 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.119041 | 0.924 |
| R-HSA-5635838 | Activation of SMO | 0.123426 | 0.909 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.146236 | 0.835 |
| R-HSA-450294 | MAP kinase activation | 0.076308 | 1.117 |
| R-HSA-112043 | PLC beta mediated events | 0.076308 | 1.117 |
| R-HSA-68886 | M Phase | 0.050724 | 1.295 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.051311 | 1.290 |
| R-HSA-164944 | Nef and signal transduction | 0.057538 | 1.240 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.063726 | 1.196 |
| R-HSA-447041 | CHL1 interactions | 0.063726 | 1.196 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.100012 | 1.000 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.100012 | 1.000 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.100012 | 1.000 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.105923 | 0.975 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.111796 | 0.952 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.117630 | 0.929 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.151846 | 0.819 |
| R-HSA-448424 | Interleukin-17 signaling | 0.093944 | 1.027 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.046270 | 1.335 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.094563 | 1.024 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.074578 | 1.127 |
| R-HSA-69275 | G2/M Transition | 0.047064 | 1.327 |
| R-HSA-180024 | DARPP-32 events | 0.022642 | 1.645 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.129185 | 0.889 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.048454 | 1.315 |
| R-HSA-8939211 | ESR-mediated signaling | 0.090385 | 1.044 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.098010 | 1.009 |
| R-HSA-9659379 | Sensory processing of sound | 0.112617 | 0.948 |
| R-HSA-168249 | Innate Immune System | 0.059772 | 1.224 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.069873 | 1.156 |
| R-HSA-210990 | PECAM1 interactions | 0.088074 | 1.055 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 0.111796 | 0.952 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.151846 | 0.819 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.157420 | 0.803 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.162957 | 0.788 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.067030 | 1.174 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.089929 | 1.046 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.151846 | 0.819 |
| R-HSA-168255 | Influenza Infection | 0.142661 | 0.846 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.045341 | 1.344 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.100062 | 1.000 |
| R-HSA-70171 | Glycolysis | 0.037414 | 1.427 |
| R-HSA-2262752 | Cellular responses to stress | 0.080550 | 1.094 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.067030 | 1.174 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.020904 | 1.680 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.114748 | 0.940 |
| R-HSA-1500620 | Meiosis | 0.125555 | 0.901 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.035882 | 1.445 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.082019 | 1.086 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.088074 | 1.055 |
| R-HSA-8876725 | Protein methylation | 0.117630 | 0.929 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.123426 | 0.909 |
| R-HSA-9664420 | Killing mechanisms | 0.123426 | 0.909 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.123426 | 0.909 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.016906 | 1.772 |
| R-HSA-2559583 | Cellular Senescence | 0.144183 | 0.841 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.046270 | 1.335 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.041421 | 1.383 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.111796 | 0.952 |
| R-HSA-210991 | Basigin interactions | 0.157420 | 0.803 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.162957 | 0.788 |
| R-HSA-9766229 | Degradation of CDH1 | 0.054745 | 1.262 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.078211 | 1.107 |
| R-HSA-70326 | Glucose metabolism | 0.056066 | 1.251 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.161574 | 0.792 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.161574 | 0.792 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.161574 | 0.792 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.091448 | 1.039 |
| R-HSA-9658195 | Leishmania infection | 0.049302 | 1.307 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.049302 | 1.307 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.050077 | 1.300 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.053031 | 1.275 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.016991 | 1.770 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.016991 | 1.770 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.140589 | 0.852 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.021768 | 1.662 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.044422 | 1.352 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.020299 | 1.693 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.140589 | 0.852 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 0.157420 | 0.803 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.162957 | 0.788 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.015219 | 1.818 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.044422 | 1.352 |
| R-HSA-199991 | Membrane Trafficking | 0.032739 | 1.485 |
| R-HSA-9664873 | Pexophagy | 0.082047 | 1.086 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.046905 | 1.329 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.133645 | 0.874 |
| R-HSA-373755 | Semaphorin interactions | 0.011803 | 1.928 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.039203 | 1.407 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.058322 | 1.234 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.134906 | 0.870 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.110496 | 0.957 |
| R-HSA-70263 | Gluconeogenesis | 0.053062 | 1.275 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.100062 | 1.000 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.134369 | 0.872 |
| R-HSA-5688426 | Deubiquitination | 0.108689 | 0.964 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.038815 | 1.411 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.070693 | 1.151 |
| R-HSA-9833482 | PKR-mediated signaling | 0.114748 | 0.940 |
| R-HSA-201556 | Signaling by ALK | 0.037337 | 1.428 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.080738 | 1.093 |
| R-HSA-109582 | Hemostasis | 0.161266 | 0.792 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.051301 | 1.290 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.105187 | 0.978 |
| R-HSA-73887 | Death Receptor Signaling | 0.105187 | 0.978 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.152391 | 0.817 |
| R-HSA-422475 | Axon guidance | 0.080447 | 1.094 |
| R-HSA-9675108 | Nervous system development | 0.103503 | 0.985 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.108387 | 0.965 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.081956 | 1.086 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.035604 | 1.449 |
| R-HSA-5357801 | Programmed Cell Death | 0.061973 | 1.208 |
| R-HSA-109581 | Apoptosis | 0.116260 | 0.935 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.059904 | 1.223 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.163886 | 0.785 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.166203 | 0.779 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.168458 | 0.774 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.168458 | 0.774 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 0.168458 | 0.774 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.168458 | 0.774 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.168527 | 0.773 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.170856 | 0.767 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.173924 | 0.760 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.173924 | 0.760 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.179354 | 0.746 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.179354 | 0.746 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.179354 | 0.746 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.179354 | 0.746 |
| R-HSA-9679506 | SARS-CoV Infections | 0.179918 | 0.745 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.180579 | 0.743 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.184748 | 0.733 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.184748 | 0.733 |
| R-HSA-211000 | Gene Silencing by RNA | 0.184939 | 0.733 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.190107 | 0.721 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.190107 | 0.721 |
| R-HSA-3295583 | TRP channels | 0.190107 | 0.721 |
| R-HSA-70635 | Urea cycle | 0.190107 | 0.721 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.190107 | 0.721 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.190107 | 0.721 |
| R-HSA-202403 | TCR signaling | 0.192043 | 0.717 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.195432 | 0.709 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.195432 | 0.709 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.195432 | 0.709 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.195432 | 0.709 |
| R-HSA-397014 | Muscle contraction | 0.197126 | 0.705 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.200722 | 0.697 |
| R-HSA-622312 | Inflammasomes | 0.200722 | 0.697 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.203962 | 0.690 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.205977 | 0.686 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.205977 | 0.686 |
| R-HSA-373760 | L1CAM interactions | 0.211154 | 0.675 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.211198 | 0.675 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.211198 | 0.675 |
| R-HSA-2424491 | DAP12 signaling | 0.211198 | 0.675 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.211198 | 0.675 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.211198 | 0.675 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.211198 | 0.675 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.211198 | 0.675 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.211198 | 0.675 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.211198 | 0.675 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.211198 | 0.675 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.215963 | 0.666 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.216385 | 0.665 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.216385 | 0.665 |
| R-HSA-182971 | EGFR downregulation | 0.216385 | 0.665 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.218371 | 0.661 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.218371 | 0.661 |
| R-HSA-68875 | Mitotic Prophase | 0.220782 | 0.656 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.221538 | 0.655 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.221538 | 0.655 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.225610 | 0.647 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.225610 | 0.647 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.226658 | 0.645 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.226658 | 0.645 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.226658 | 0.645 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.226658 | 0.645 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.226658 | 0.645 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.226658 | 0.645 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.226658 | 0.645 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.228027 | 0.642 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.230446 | 0.637 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.231744 | 0.635 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.231744 | 0.635 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.231744 | 0.635 |
| R-HSA-69206 | G1/S Transition | 0.235290 | 0.628 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.236797 | 0.626 |
| R-HSA-5205647 | Mitophagy | 0.236797 | 0.626 |
| R-HSA-203615 | eNOS activation | 0.236797 | 0.626 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.236797 | 0.626 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.236797 | 0.626 |
| R-HSA-69481 | G2/M Checkpoints | 0.240139 | 0.620 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.241818 | 0.617 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.241818 | 0.617 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.241818 | 0.617 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.241818 | 0.617 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.246805 | 0.608 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.246805 | 0.608 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.246805 | 0.608 |
| R-HSA-163560 | Triglyceride catabolism | 0.246805 | 0.608 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.246805 | 0.608 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.246805 | 0.608 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.247423 | 0.607 |
| R-HSA-1474165 | Reproduction | 0.249853 | 0.602 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.251760 | 0.599 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.251760 | 0.599 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.256683 | 0.591 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.256683 | 0.591 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.256683 | 0.591 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.261574 | 0.582 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.261574 | 0.582 |
| R-HSA-69541 | Stabilization of p53 | 0.261574 | 0.582 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.261574 | 0.582 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.266433 | 0.574 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.266433 | 0.574 |
| R-HSA-202433 | Generation of second messenger molecules | 0.266433 | 0.574 |
| R-HSA-5260271 | Diseases of Immune System | 0.266433 | 0.574 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.266433 | 0.574 |
| R-HSA-9646399 | Aggrephagy | 0.266433 | 0.574 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.271260 | 0.567 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.271260 | 0.567 |
| R-HSA-9607240 | FLT3 Signaling | 0.271260 | 0.567 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.271744 | 0.566 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.276055 | 0.559 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.276610 | 0.558 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.276610 | 0.558 |
| R-HSA-9664407 | Parasite infection | 0.276610 | 0.558 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.278360 | 0.555 |
| R-HSA-991365 | Activation of GABAB receptors | 0.280820 | 0.552 |
| R-HSA-977444 | GABA B receptor activation | 0.280820 | 0.552 |
| R-HSA-165159 | MTOR signalling | 0.280820 | 0.552 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.285553 | 0.544 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.285553 | 0.544 |
| R-HSA-69236 | G1 Phase | 0.290256 | 0.537 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.290256 | 0.537 |
| R-HSA-2172127 | DAP12 interactions | 0.290256 | 0.537 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.294927 | 0.530 |
| R-HSA-774815 | Nucleosome assembly | 0.294927 | 0.530 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.294927 | 0.530 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.294927 | 0.530 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.294927 | 0.530 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.294927 | 0.530 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.294927 | 0.530 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.294927 | 0.530 |
| R-HSA-69242 | S Phase | 0.298476 | 0.525 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.299569 | 0.524 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.299569 | 0.524 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.299569 | 0.524 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.299569 | 0.524 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.299569 | 0.524 |
| R-HSA-75153 | Apoptotic execution phase | 0.299569 | 0.524 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.303324 | 0.518 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.304180 | 0.517 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.304180 | 0.517 |
| R-HSA-437239 | Recycling pathway of L1 | 0.304180 | 0.517 |
| R-HSA-5620924 | Intraflagellar transport | 0.308761 | 0.510 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.308761 | 0.510 |
| R-HSA-9634597 | GPER1 signaling | 0.308761 | 0.510 |
| R-HSA-418594 | G alpha (i) signalling events | 0.311362 | 0.507 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.313312 | 0.504 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.313312 | 0.504 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.322325 | 0.492 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.322325 | 0.492 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.322654 | 0.491 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.326788 | 0.486 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.326788 | 0.486 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.326788 | 0.486 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.331222 | 0.480 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.331222 | 0.480 |
| R-HSA-8953854 | Metabolism of RNA | 0.333602 | 0.477 |
| R-HSA-72649 | Translation initiation complex formation | 0.335626 | 0.474 |
| R-HSA-5663205 | Infectious disease | 0.336277 | 0.473 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.337068 | 0.472 |
| R-HSA-418597 | G alpha (z) signalling events | 0.340002 | 0.469 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.343405 | 0.464 |
| R-HSA-5619102 | SLC transporter disorders | 0.344243 | 0.463 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.344349 | 0.463 |
| R-HSA-75893 | TNF signaling | 0.344349 | 0.463 |
| R-HSA-177929 | Signaling by EGFR | 0.344349 | 0.463 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.344349 | 0.463 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.352959 | 0.452 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.357222 | 0.447 |
| R-HSA-8979227 | Triglyceride metabolism | 0.357222 | 0.447 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.360886 | 0.443 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.360886 | 0.443 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.360886 | 0.443 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.360886 | 0.443 |
| R-HSA-977443 | GABA receptor activation | 0.361457 | 0.442 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.361457 | 0.442 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.361457 | 0.442 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.365664 | 0.437 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.365664 | 0.437 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.369844 | 0.432 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.369844 | 0.432 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.369844 | 0.432 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.373997 | 0.427 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.373997 | 0.427 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.373997 | 0.427 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.373997 | 0.427 |
| R-HSA-8848021 | Signaling by PTK6 | 0.373997 | 0.427 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.373997 | 0.427 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.378122 | 0.422 |
| R-HSA-1500931 | Cell-Cell communication | 0.381030 | 0.419 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.382221 | 0.418 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.386293 | 0.413 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.390338 | 0.409 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.393486 | 0.405 |
| R-HSA-5218859 | Regulated Necrosis | 0.394356 | 0.404 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.402315 | 0.395 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.402315 | 0.395 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.402315 | 0.395 |
| R-HSA-8978934 | Metabolism of cofactors | 0.406256 | 0.391 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.406256 | 0.391 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.406256 | 0.391 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.409814 | 0.387 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.410171 | 0.387 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.410171 | 0.387 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.410171 | 0.387 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.410171 | 0.387 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.414060 | 0.383 |
| R-HSA-4086398 | Ca2+ pathway | 0.414060 | 0.383 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.414060 | 0.383 |
| R-HSA-9749641 | Aspirin ADME | 0.414060 | 0.383 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.414384 | 0.383 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.417924 | 0.379 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 0.417924 | 0.379 |
| R-HSA-380287 | Centrosome maturation | 0.421763 | 0.375 |
| R-HSA-8852135 | Protein ubiquitination | 0.421763 | 0.375 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.421763 | 0.375 |
| R-HSA-388396 | GPCR downstream signalling | 0.425891 | 0.371 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.430238 | 0.366 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.433129 | 0.363 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.433129 | 0.363 |
| R-HSA-72172 | mRNA Splicing | 0.434727 | 0.362 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.435666 | 0.361 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.440583 | 0.356 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.444273 | 0.352 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.452494 | 0.344 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.458796 | 0.338 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.462367 | 0.335 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.462367 | 0.335 |
| R-HSA-418990 | Adherens junctions interactions | 0.465613 | 0.332 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.465916 | 0.332 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.465916 | 0.332 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.469440 | 0.328 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.472942 | 0.325 |
| R-HSA-156902 | Peptide chain elongation | 0.472942 | 0.325 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.479878 | 0.319 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.483311 | 0.316 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.483311 | 0.316 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.483311 | 0.316 |
| R-HSA-162906 | HIV Infection | 0.484945 | 0.314 |
| R-HSA-9824446 | Viral Infection Pathways | 0.486669 | 0.313 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.486723 | 0.313 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.490111 | 0.310 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.490111 | 0.310 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.493478 | 0.307 |
| R-HSA-913531 | Interferon Signaling | 0.498447 | 0.302 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.500146 | 0.301 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.500146 | 0.301 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.503447 | 0.298 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.503447 | 0.298 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.505917 | 0.296 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.509943 | 0.292 |
| R-HSA-1643685 | Disease | 0.518111 | 0.286 |
| R-HSA-372790 | Signaling by GPCR | 0.521928 | 0.282 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.522805 | 0.282 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.525958 | 0.279 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.526337 | 0.279 |
| R-HSA-192823 | Viral mRNA Translation | 0.529090 | 0.276 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.532202 | 0.274 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.532202 | 0.274 |
| R-HSA-421270 | Cell-cell junction organization | 0.534347 | 0.272 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.535293 | 0.271 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.535293 | 0.271 |
| R-HSA-1266738 | Developmental Biology | 0.538821 | 0.269 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.541415 | 0.266 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.544446 | 0.264 |
| R-HSA-69239 | Synthesis of DNA | 0.544446 | 0.264 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.547457 | 0.262 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.547457 | 0.262 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.547457 | 0.262 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.550449 | 0.259 |
| R-HSA-597592 | Post-translational protein modification | 0.554097 | 0.256 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.559306 | 0.252 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.559306 | 0.252 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.559306 | 0.252 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.559306 | 0.252 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.562220 | 0.250 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.565115 | 0.248 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.573686 | 0.241 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.576505 | 0.239 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.576505 | 0.239 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.579306 | 0.237 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.579306 | 0.237 |
| R-HSA-446728 | Cell junction organization | 0.585984 | 0.232 |
| R-HSA-73886 | Chromosome Maintenance | 0.590329 | 0.229 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.590329 | 0.229 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.593270 | 0.227 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.595732 | 0.225 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.605792 | 0.218 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.606328 | 0.217 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.609648 | 0.215 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.611522 | 0.214 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.618024 | 0.209 |
| R-HSA-195721 | Signaling by WNT | 0.621466 | 0.207 |
| R-HSA-112316 | Neuronal System | 0.627924 | 0.202 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.636493 | 0.196 |
| R-HSA-163685 | Integration of energy metabolism | 0.636493 | 0.196 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.641293 | 0.193 |
| R-HSA-6807070 | PTEN Regulation | 0.643669 | 0.191 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.653020 | 0.185 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.655319 | 0.184 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.657603 | 0.182 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.664367 | 0.178 |
| R-HSA-166520 | Signaling by NTRKs | 0.666592 | 0.176 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.670998 | 0.173 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.675346 | 0.170 |
| R-HSA-69306 | DNA Replication | 0.677499 | 0.169 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.677499 | 0.169 |
| R-HSA-9610379 | HCMV Late Events | 0.685969 | 0.164 |
| R-HSA-162587 | HIV Life Cycle | 0.685969 | 0.164 |
| R-HSA-9711097 | Cellular response to starvation | 0.688052 | 0.162 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.692177 | 0.160 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.713917 | 0.146 |
| R-HSA-72306 | tRNA processing | 0.713917 | 0.146 |
| R-HSA-418555 | G alpha (s) signalling events | 0.715817 | 0.145 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.723290 | 0.141 |
| R-HSA-392499 | Metabolism of proteins | 0.745248 | 0.128 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.746258 | 0.127 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.747788 | 0.126 |
| R-HSA-983712 | Ion channel transport | 0.747944 | 0.126 |
| R-HSA-9609690 | HCMV Early Events | 0.759443 | 0.120 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.764573 | 0.117 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.768884 | 0.114 |
| R-HSA-9748784 | Drug ADME | 0.793686 | 0.100 |
| R-HSA-382551 | Transport of small molecules | 0.795780 | 0.099 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.796453 | 0.099 |
| R-HSA-8951664 | Neddylation | 0.797781 | 0.098 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.804427 | 0.095 |
| R-HSA-72312 | rRNA processing | 0.812117 | 0.090 |
| R-HSA-157118 | Signaling by NOTCH | 0.821907 | 0.085 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.833058 | 0.079 |
| R-HSA-9609646 | HCMV Infection | 0.833436 | 0.079 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.858177 | 0.066 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.861931 | 0.065 |
| R-HSA-73894 | DNA Repair | 0.920451 | 0.036 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.922568 | 0.035 |
| R-HSA-8978868 | Fatty acid metabolism | 0.942472 | 0.026 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.948024 | 0.023 |
| R-HSA-72766 | Translation | 0.950429 | 0.022 |
| R-HSA-211859 | Biological oxidations | 0.973822 | 0.012 |
| R-HSA-74160 | Gene expression (Transcription) | 0.992993 | 0.003 |
| R-HSA-212436 | Generic Transcription Pathway | 0.994022 | 0.003 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.997255 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.998203 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999647 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999818 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.803 | -0.012 | 1 | 0.725 |
BRAF |
0.801 | 0.048 | -4 | 0.811 |
TAK1 |
0.799 | -0.029 | 1 | 0.777 |
NIK |
0.798 | 0.130 | -3 | 0.840 |
DAPK2 |
0.798 | 0.127 | -3 | 0.825 |
GCK |
0.798 | 0.037 | 1 | 0.731 |
CAMK1B |
0.797 | 0.205 | -3 | 0.841 |
VRK1 |
0.797 | -0.049 | 2 | 0.823 |
VRK2 |
0.796 | -0.120 | 1 | 0.769 |
PKR |
0.795 | -0.042 | 1 | 0.745 |
EEF2K |
0.794 | 0.002 | 3 | 0.787 |
TTK |
0.794 | 0.019 | -2 | 0.788 |
MST2 |
0.794 | 0.005 | 1 | 0.738 |
TSSK2 |
0.793 | 0.336 | -5 | 0.622 |
CHK1 |
0.793 | 0.338 | -3 | 0.821 |
MST1 |
0.793 | -0.020 | 1 | 0.717 |
ALK4 |
0.793 | 0.063 | -2 | 0.802 |
MINK |
0.792 | -0.028 | 1 | 0.719 |
DAPK3 |
0.792 | 0.111 | -3 | 0.826 |
BMPR2 |
0.792 | -0.037 | -2 | 0.854 |
PDK1 |
0.792 | -0.001 | 1 | 0.749 |
TNIK |
0.791 | -0.022 | 3 | 0.817 |
TAO3 |
0.790 | 0.006 | 1 | 0.719 |
NEK1 |
0.790 | -0.035 | 1 | 0.730 |
TAO2 |
0.790 | -0.035 | 2 | 0.773 |
MEK1 |
0.790 | -0.054 | 2 | 0.766 |
NEK5 |
0.789 | -0.042 | 1 | 0.745 |
CAMLCK |
0.789 | 0.043 | -2 | 0.789 |
BUB1 |
0.789 | 0.318 | -5 | 0.717 |
LRRK2 |
0.788 | -0.090 | 2 | 0.762 |
SMMLCK |
0.788 | 0.088 | -3 | 0.801 |
MEKK2 |
0.788 | -0.075 | 2 | 0.729 |
DLK |
0.788 | 0.010 | 1 | 0.781 |
DMPK1 |
0.788 | 0.083 | -3 | 0.817 |
PASK |
0.788 | 0.091 | -3 | 0.823 |
MAP3K15 |
0.788 | -0.046 | 1 | 0.707 |
KHS2 |
0.787 | 0.022 | 1 | 0.714 |
KHS1 |
0.787 | -0.007 | 1 | 0.703 |
BMPR1B |
0.787 | 0.142 | 1 | 0.821 |
HPK1 |
0.787 | 0.007 | 1 | 0.713 |
LATS1 |
0.787 | 0.050 | -3 | 0.834 |
MEK5 |
0.786 | -0.116 | 2 | 0.750 |
OSR1 |
0.786 | -0.040 | 2 | 0.719 |
ALK2 |
0.786 | 0.067 | -2 | 0.791 |
ALPHAK3 |
0.785 | -0.032 | -1 | 0.644 |
MST3 |
0.785 | -0.008 | 2 | 0.761 |
HGK |
0.785 | -0.048 | 3 | 0.822 |
TSSK1 |
0.785 | 0.288 | -3 | 0.855 |
MOS |
0.785 | 0.067 | 1 | 0.806 |
DAPK1 |
0.784 | 0.107 | -3 | 0.804 |
ANKRD3 |
0.784 | -0.028 | 1 | 0.781 |
NEK8 |
0.783 | -0.076 | 2 | 0.749 |
BIKE |
0.783 | 0.003 | 1 | 0.587 |
RAF1 |
0.783 | 0.059 | 1 | 0.784 |
MEKK3 |
0.783 | -0.043 | 1 | 0.735 |
PRPK |
0.782 | -0.079 | -1 | 0.735 |
ASK1 |
0.782 | -0.112 | 1 | 0.697 |
TGFBR1 |
0.782 | 0.065 | -2 | 0.787 |
CDKL1 |
0.781 | 0.066 | -3 | 0.786 |
MEKK6 |
0.781 | -0.066 | 1 | 0.715 |
YSK4 |
0.781 | -0.048 | 1 | 0.712 |
CHK2 |
0.780 | 0.197 | -3 | 0.705 |
ACVR2B |
0.780 | 0.080 | -2 | 0.786 |
ACVR2A |
0.780 | 0.087 | -2 | 0.781 |
ZAK |
0.780 | -0.047 | 1 | 0.726 |
MEKK1 |
0.779 | -0.123 | 1 | 0.730 |
LKB1 |
0.779 | -0.116 | -3 | 0.724 |
CAMKK1 |
0.779 | -0.129 | -2 | 0.736 |
YSK1 |
0.779 | -0.059 | 2 | 0.717 |
DCAMKL2 |
0.779 | 0.139 | -3 | 0.840 |
BMPR1A |
0.779 | 0.128 | 1 | 0.814 |
DCAMKL1 |
0.779 | 0.119 | -3 | 0.826 |
NEK11 |
0.779 | -0.081 | 1 | 0.727 |
AMPKA1 |
0.779 | 0.163 | -3 | 0.849 |
NLK |
0.778 | -0.004 | 1 | 0.699 |
NUAK2 |
0.778 | 0.185 | -3 | 0.853 |
NEK4 |
0.778 | -0.103 | 1 | 0.710 |
ROCK2 |
0.778 | 0.039 | -3 | 0.816 |
ATR |
0.777 | -0.025 | 1 | 0.732 |
SKMLCK |
0.777 | 0.064 | -2 | 0.805 |
AAK1 |
0.777 | 0.035 | 1 | 0.477 |
MYO3B |
0.777 | -0.062 | 2 | 0.729 |
CAMK1D |
0.777 | 0.206 | -3 | 0.746 |
TLK1 |
0.776 | 0.013 | -2 | 0.830 |
STLK3 |
0.776 | -0.108 | 1 | 0.690 |
PKN3 |
0.776 | 0.124 | -3 | 0.807 |
CAMKK2 |
0.776 | -0.147 | -2 | 0.733 |
MPSK1 |
0.775 | -0.041 | 1 | 0.653 |
ICK |
0.775 | 0.029 | -3 | 0.810 |
MYO3A |
0.775 | -0.082 | 1 | 0.691 |
CAMK1A |
0.774 | 0.240 | -3 | 0.722 |
JNK2 |
0.774 | 0.004 | 1 | 0.478 |
HRI |
0.774 | -0.038 | -2 | 0.824 |
P38A |
0.773 | -0.003 | 1 | 0.551 |
PBK |
0.773 | -0.048 | 1 | 0.632 |
LOK |
0.772 | -0.051 | -2 | 0.718 |
PKN2 |
0.772 | 0.132 | -3 | 0.831 |
PRKD3 |
0.772 | 0.276 | -3 | 0.765 |
GRK6 |
0.771 | 0.036 | 1 | 0.821 |
PERK |
0.771 | -0.060 | -2 | 0.801 |
PLK1 |
0.771 | 0.018 | -2 | 0.764 |
PRP4 |
0.771 | -0.021 | -3 | 0.660 |
PIM1 |
0.771 | 0.105 | -3 | 0.824 |
AMPKA2 |
0.771 | 0.161 | -3 | 0.837 |
COT |
0.771 | 0.056 | 2 | 0.853 |
PRKD1 |
0.770 | 0.370 | -3 | 0.784 |
MLK2 |
0.770 | -0.085 | 2 | 0.740 |
CAMK4 |
0.770 | 0.177 | -3 | 0.830 |
TLK2 |
0.770 | -0.046 | 1 | 0.722 |
MEK2 |
0.770 | -0.174 | 2 | 0.733 |
NEK9 |
0.770 | -0.060 | 2 | 0.754 |
CRIK |
0.769 | 0.066 | -3 | 0.752 |
MRCKA |
0.769 | 0.057 | -3 | 0.796 |
JNK3 |
0.769 | -0.028 | 1 | 0.514 |
WNK4 |
0.769 | -0.014 | -2 | 0.812 |
GRK7 |
0.769 | 0.032 | 1 | 0.747 |
TAO1 |
0.768 | -0.046 | 1 | 0.656 |
ROCK1 |
0.768 | 0.038 | -3 | 0.793 |
MAPKAPK3 |
0.768 | 0.191 | -3 | 0.786 |
CAMK2D |
0.768 | 0.153 | -3 | 0.797 |
CDC7 |
0.766 | 0.106 | 1 | 0.825 |
MLK1 |
0.766 | -0.079 | 2 | 0.747 |
WNK1 |
0.766 | 0.047 | -2 | 0.825 |
MELK |
0.766 | 0.171 | -3 | 0.814 |
ERK5 |
0.766 | -0.008 | 1 | 0.659 |
RIPK1 |
0.766 | -0.022 | 1 | 0.749 |
PKCD |
0.766 | 0.046 | 2 | 0.726 |
DRAK1 |
0.765 | 0.073 | 1 | 0.776 |
GRK5 |
0.765 | -0.036 | -3 | 0.780 |
CAMK2B |
0.765 | 0.165 | 2 | 0.706 |
MYLK4 |
0.765 | 0.092 | -2 | 0.706 |
PDHK4 |
0.765 | -0.096 | 1 | 0.771 |
P70S6KB |
0.764 | 0.054 | -3 | 0.812 |
CAMK1G |
0.764 | 0.162 | -3 | 0.779 |
MASTL |
0.764 | -0.106 | -2 | 0.760 |
P38B |
0.764 | -0.019 | 1 | 0.484 |
DSTYK |
0.763 | -0.005 | 2 | 0.806 |
AKT2 |
0.763 | 0.092 | -3 | 0.742 |
GRK2 |
0.763 | 0.044 | -2 | 0.715 |
RIPK3 |
0.763 | -0.006 | 3 | 0.716 |
SGK3 |
0.762 | 0.072 | -3 | 0.784 |
MRCKB |
0.762 | 0.044 | -3 | 0.779 |
IRAK4 |
0.762 | -0.068 | 1 | 0.721 |
CHAK2 |
0.762 | -0.048 | -1 | 0.715 |
CAMK2G |
0.762 | -0.052 | 2 | 0.734 |
CLK3 |
0.762 | 0.076 | 1 | 0.708 |
PRKD2 |
0.762 | 0.272 | -3 | 0.801 |
SLK |
0.761 | -0.058 | -2 | 0.669 |
SBK |
0.761 | 0.147 | -3 | 0.652 |
MST4 |
0.761 | 0.028 | 2 | 0.773 |
NEK3 |
0.761 | -0.074 | 1 | 0.688 |
PIM3 |
0.761 | 0.038 | -3 | 0.835 |
PIM2 |
0.760 | 0.042 | -3 | 0.778 |
PDHK1 |
0.760 | -0.098 | 1 | 0.756 |
ATM |
0.760 | 0.010 | 1 | 0.696 |
HUNK |
0.759 | -0.027 | 2 | 0.780 |
TGFBR2 |
0.759 | 0.021 | -2 | 0.772 |
CLK4 |
0.759 | 0.069 | -3 | 0.806 |
CAMK2A |
0.758 | 0.159 | 2 | 0.705 |
MARK4 |
0.758 | 0.052 | 4 | 0.831 |
MTOR |
0.758 | -0.029 | 1 | 0.696 |
P90RSK |
0.757 | 0.100 | -3 | 0.781 |
HIPK1 |
0.757 | 0.012 | 1 | 0.570 |
NEK2 |
0.757 | -0.098 | 2 | 0.714 |
SGK1 |
0.757 | 0.075 | -3 | 0.677 |
CDKL5 |
0.757 | 0.037 | -3 | 0.777 |
HASPIN |
0.757 | -0.016 | -1 | 0.601 |
PLK3 |
0.757 | -0.026 | 2 | 0.721 |
NUAK1 |
0.757 | 0.184 | -3 | 0.822 |
AKT1 |
0.756 | 0.081 | -3 | 0.761 |
MLK4 |
0.756 | -0.067 | 2 | 0.656 |
MAPKAPK2 |
0.756 | 0.179 | -3 | 0.773 |
PINK1 |
0.756 | -0.096 | 1 | 0.682 |
DYRK2 |
0.755 | 0.016 | 1 | 0.559 |
TBK1 |
0.755 | -0.048 | 1 | 0.683 |
DNAPK |
0.755 | -0.023 | 1 | 0.622 |
P38G |
0.755 | -0.028 | 1 | 0.404 |
ERK2 |
0.755 | -0.050 | 1 | 0.525 |
SSTK |
0.754 | 0.094 | 4 | 0.827 |
RSK2 |
0.754 | 0.087 | -3 | 0.791 |
NEK7 |
0.753 | -0.079 | -3 | 0.726 |
MLK3 |
0.753 | -0.059 | 2 | 0.671 |
IRAK1 |
0.753 | -0.097 | -1 | 0.662 |
QIK |
0.752 | 0.090 | -3 | 0.800 |
P38D |
0.752 | -0.015 | 1 | 0.407 |
CLK1 |
0.752 | 0.092 | -3 | 0.791 |
DYRK1A |
0.752 | 0.022 | 1 | 0.597 |
WNK3 |
0.751 | -0.112 | 1 | 0.746 |
CHAK1 |
0.751 | -0.110 | 2 | 0.677 |
PAK2 |
0.751 | -0.026 | -2 | 0.685 |
SMG1 |
0.750 | -0.038 | 1 | 0.675 |
PKCH |
0.750 | 0.013 | 2 | 0.657 |
ULK2 |
0.750 | -0.109 | 2 | 0.725 |
QSK |
0.750 | 0.101 | 4 | 0.808 |
SRPK3 |
0.750 | 0.048 | -3 | 0.733 |
HIPK3 |
0.749 | 0.008 | 1 | 0.578 |
CDK5 |
0.749 | -0.032 | 1 | 0.542 |
IRE2 |
0.749 | -0.060 | 2 | 0.711 |
MARK2 |
0.749 | 0.069 | 4 | 0.732 |
IRE1 |
0.748 | -0.058 | 1 | 0.696 |
MOK |
0.748 | 0.011 | 1 | 0.579 |
GRK4 |
0.748 | -0.038 | -2 | 0.794 |
JNK1 |
0.747 | -0.041 | 1 | 0.470 |
RIPK2 |
0.747 | -0.081 | 1 | 0.686 |
PAK1 |
0.747 | -0.011 | -2 | 0.705 |
MSK1 |
0.747 | 0.072 | -3 | 0.758 |
NDR1 |
0.747 | 0.012 | -3 | 0.838 |
MAK |
0.746 | 0.012 | -2 | 0.658 |
PKCA |
0.746 | -0.002 | 2 | 0.660 |
NEK6 |
0.746 | -0.046 | -2 | 0.842 |
IKKE |
0.746 | -0.076 | 1 | 0.677 |
MARK1 |
0.746 | 0.068 | 4 | 0.795 |
SIK |
0.746 | 0.132 | -3 | 0.788 |
CDK1 |
0.746 | -0.022 | 1 | 0.493 |
TTBK2 |
0.746 | -0.109 | 2 | 0.646 |
HIPK4 |
0.746 | 0.026 | 1 | 0.659 |
ERK1 |
0.745 | -0.042 | 1 | 0.475 |
CDK14 |
0.745 | -0.007 | 1 | 0.497 |
PKCB |
0.745 | 0.017 | 2 | 0.670 |
PKCZ |
0.745 | -0.035 | 2 | 0.703 |
RSK3 |
0.745 | 0.063 | -3 | 0.773 |
CDK2 |
0.745 | -0.029 | 1 | 0.585 |
PLK2 |
0.745 | -0.014 | -3 | 0.700 |
DYRK3 |
0.744 | 0.021 | 1 | 0.575 |
MARK3 |
0.744 | 0.080 | 4 | 0.766 |
AURB |
0.744 | 0.019 | -2 | 0.587 |
IKKB |
0.744 | -0.053 | -2 | 0.731 |
PAK3 |
0.743 | -0.025 | -2 | 0.705 |
LATS2 |
0.743 | 0.023 | -5 | 0.406 |
MSK2 |
0.743 | 0.057 | -3 | 0.746 |
AURA |
0.743 | 0.024 | -2 | 0.565 |
RSK4 |
0.743 | 0.065 | -3 | 0.778 |
PKN1 |
0.743 | 0.120 | -3 | 0.748 |
PHKG1 |
0.743 | 0.086 | -3 | 0.828 |
PKCG |
0.742 | -0.001 | 2 | 0.678 |
P70S6K |
0.742 | 0.044 | -3 | 0.728 |
MNK2 |
0.742 | 0.071 | -2 | 0.726 |
ERK7 |
0.742 | -0.055 | 2 | 0.452 |
DYRK1B |
0.741 | -0.010 | 1 | 0.502 |
MNK1 |
0.741 | 0.054 | -2 | 0.728 |
SRPK1 |
0.741 | 0.049 | -3 | 0.764 |
NIM1 |
0.740 | -0.028 | 3 | 0.726 |
PKACG |
0.740 | 0.018 | -2 | 0.661 |
GRK3 |
0.740 | 0.037 | -2 | 0.673 |
GSK3B |
0.740 | -0.025 | 4 | 0.405 |
GCN2 |
0.740 | -0.061 | 2 | 0.706 |
PLK4 |
0.740 | -0.053 | 2 | 0.619 |
PKG2 |
0.740 | 0.032 | -2 | 0.604 |
PKCE |
0.740 | 0.024 | 2 | 0.658 |
PKCT |
0.739 | 0.006 | 2 | 0.666 |
MAPKAPK5 |
0.738 | 0.087 | -3 | 0.701 |
IKKA |
0.738 | -0.025 | -2 | 0.730 |
GRK1 |
0.737 | -0.029 | -2 | 0.735 |
BCKDK |
0.737 | 0.012 | -1 | 0.825 |
PKCI |
0.736 | -0.006 | 2 | 0.668 |
CDK6 |
0.736 | -0.051 | 1 | 0.475 |
NDR2 |
0.736 | 0.022 | -3 | 0.837 |
ULK1 |
0.735 | -0.112 | -3 | 0.711 |
CLK2 |
0.735 | 0.082 | -3 | 0.800 |
CDK17 |
0.735 | -0.027 | 1 | 0.408 |
CDK8 |
0.735 | -0.037 | 1 | 0.520 |
PKACB |
0.734 | 0.055 | -2 | 0.606 |
CDK18 |
0.734 | -0.009 | 1 | 0.453 |
DYRK4 |
0.734 | 0.001 | 1 | 0.481 |
CK1D |
0.734 | 0.029 | -3 | 0.516 |
CDK16 |
0.734 | -0.012 | 1 | 0.426 |
GSK3A |
0.733 | -0.027 | 4 | 0.411 |
CDK4 |
0.733 | -0.052 | 1 | 0.462 |
BRSK2 |
0.732 | 0.051 | -3 | 0.814 |
AKT3 |
0.732 | 0.059 | -3 | 0.689 |
HIPK2 |
0.731 | 0.003 | 1 | 0.469 |
CDK13 |
0.731 | -0.053 | 1 | 0.500 |
PHKG2 |
0.730 | 0.081 | -3 | 0.824 |
AURC |
0.730 | 0.025 | -2 | 0.596 |
CK1A2 |
0.730 | 0.029 | -3 | 0.522 |
CDK7 |
0.730 | -0.051 | 1 | 0.525 |
CDK12 |
0.730 | -0.048 | 1 | 0.476 |
BRSK1 |
0.730 | 0.059 | -3 | 0.804 |
STK33 |
0.729 | -0.130 | 2 | 0.585 |
PKACA |
0.729 | 0.056 | -2 | 0.566 |
CDK3 |
0.728 | -0.026 | 1 | 0.425 |
SRPK2 |
0.728 | 0.056 | -3 | 0.707 |
SNRK |
0.727 | -0.050 | 2 | 0.648 |
CK1E |
0.727 | 0.032 | -3 | 0.560 |
CDK10 |
0.726 | -0.021 | 1 | 0.481 |
YANK3 |
0.726 | -0.022 | 2 | 0.411 |
TTBK1 |
0.725 | -0.094 | 2 | 0.591 |
CDK9 |
0.724 | -0.068 | 1 | 0.509 |
PAK6 |
0.724 | 0.050 | -2 | 0.628 |
CDK19 |
0.722 | -0.034 | 1 | 0.479 |
FAM20C |
0.719 | 0.018 | 2 | 0.539 |
CK2A2 |
0.718 | 0.019 | 1 | 0.691 |
KIS |
0.715 | 0.016 | 1 | 0.541 |
PRKX |
0.714 | 0.068 | -3 | 0.772 |
YANK2 |
0.714 | -0.041 | 2 | 0.416 |
PAK5 |
0.711 | 0.001 | -2 | 0.567 |
PDHK3_TYR |
0.710 | -0.001 | 4 | 0.865 |
CK2A1 |
0.709 | 0.005 | 1 | 0.674 |
PDHK4_TYR |
0.708 | 0.004 | 2 | 0.811 |
MAP2K4_TYR |
0.706 | -0.064 | -1 | 0.769 |
MAP2K6_TYR |
0.706 | -0.046 | -1 | 0.770 |
EPHB4 |
0.706 | 0.069 | -1 | 0.766 |
TESK1_TYR |
0.705 | -0.064 | 3 | 0.835 |
PDHK1_TYR |
0.705 | -0.023 | -1 | 0.759 |
BMPR2_TYR |
0.705 | -0.028 | -1 | 0.723 |
PKG1 |
0.705 | 0.024 | -2 | 0.534 |
EPHA6 |
0.703 | 0.020 | -1 | 0.734 |
RET |
0.702 | -0.042 | 1 | 0.739 |
MAP2K7_TYR |
0.702 | -0.175 | 2 | 0.786 |
TYRO3 |
0.701 | -0.007 | 3 | 0.771 |
PINK1_TYR |
0.701 | -0.119 | 1 | 0.762 |
MST1R |
0.701 | -0.010 | 3 | 0.786 |
ABL2 |
0.701 | -0.003 | -1 | 0.701 |
ROS1 |
0.701 | -0.007 | 3 | 0.745 |
CSF1R |
0.700 | -0.019 | 3 | 0.767 |
EPHB1 |
0.700 | 0.087 | 1 | 0.811 |
FER |
0.700 | 0.010 | 1 | 0.826 |
PKMYT1_TYR |
0.700 | -0.121 | 3 | 0.823 |
EPHB3 |
0.699 | 0.084 | -1 | 0.766 |
PAK4 |
0.699 | -0.009 | -2 | 0.577 |
INSRR |
0.699 | 0.027 | 3 | 0.706 |
DDR1 |
0.699 | -0.023 | 4 | 0.830 |
TXK |
0.699 | 0.058 | 1 | 0.808 |
LIMK2_TYR |
0.698 | -0.051 | -3 | 0.815 |
TYK2 |
0.698 | -0.067 | 1 | 0.740 |
CK1G1 |
0.698 | -0.004 | -3 | 0.564 |
ABL1 |
0.698 | -0.007 | -1 | 0.690 |
FGR |
0.697 | -0.024 | 1 | 0.773 |
EPHA4 |
0.697 | 0.045 | 2 | 0.733 |
EPHB2 |
0.697 | 0.072 | -1 | 0.743 |
FLT3 |
0.695 | -0.017 | 3 | 0.767 |
SRMS |
0.694 | 0.014 | 1 | 0.827 |
JAK2 |
0.694 | -0.078 | 1 | 0.738 |
KIT |
0.693 | -0.038 | 3 | 0.771 |
PDGFRB |
0.693 | -0.036 | 3 | 0.781 |
ITK |
0.692 | -0.015 | -1 | 0.661 |
YES1 |
0.692 | -0.062 | -1 | 0.691 |
JAK3 |
0.691 | -0.069 | 1 | 0.731 |
LIMK1_TYR |
0.691 | -0.143 | 2 | 0.775 |
AXL |
0.690 | -0.012 | 3 | 0.735 |
CK1G3 |
0.690 | -0.014 | -3 | 0.407 |
TNK2 |
0.690 | -0.038 | 3 | 0.736 |
MERTK |
0.690 | 0.003 | 3 | 0.727 |
PDGFRA |
0.689 | -0.028 | 3 | 0.782 |
BMX |
0.689 | 0.013 | -1 | 0.590 |
HCK |
0.689 | -0.043 | -1 | 0.655 |
EPHA7 |
0.689 | 0.037 | 2 | 0.732 |
TEC |
0.688 | -0.000 | -1 | 0.619 |
MET |
0.688 | -0.052 | 3 | 0.758 |
ALK |
0.688 | -0.009 | 3 | 0.712 |
FGFR2 |
0.688 | -0.080 | 3 | 0.748 |
TEK |
0.688 | -0.045 | 3 | 0.705 |
FRK |
0.688 | 0.013 | -1 | 0.694 |
KDR |
0.687 | -0.066 | 3 | 0.722 |
NTRK1 |
0.687 | -0.027 | -1 | 0.763 |
EPHA5 |
0.687 | 0.066 | 2 | 0.721 |
EPHA3 |
0.687 | 0.014 | 2 | 0.710 |
FGFR1 |
0.687 | -0.061 | 3 | 0.731 |
LTK |
0.686 | -0.019 | 3 | 0.734 |
BTK |
0.686 | -0.060 | -1 | 0.657 |
TNNI3K_TYR |
0.686 | -0.027 | 1 | 0.719 |
LCK |
0.686 | -0.052 | -1 | 0.641 |
PTK2B |
0.685 | 0.041 | -1 | 0.652 |
BLK |
0.684 | -0.041 | -1 | 0.655 |
TNK1 |
0.684 | -0.060 | 3 | 0.756 |
INSR |
0.684 | -0.028 | 3 | 0.693 |
JAK1 |
0.683 | -0.054 | 1 | 0.688 |
NTRK3 |
0.682 | -0.018 | -1 | 0.738 |
NEK10_TYR |
0.682 | -0.092 | 1 | 0.634 |
ERBB2 |
0.681 | -0.063 | 1 | 0.728 |
FLT1 |
0.681 | -0.076 | -1 | 0.717 |
NTRK2 |
0.681 | -0.051 | 3 | 0.714 |
DDR2 |
0.681 | 0.019 | 3 | 0.710 |
EPHA1 |
0.681 | -0.016 | 3 | 0.737 |
PTK6 |
0.681 | -0.100 | -1 | 0.634 |
FLT4 |
0.680 | -0.068 | 3 | 0.716 |
EPHA8 |
0.680 | 0.009 | -1 | 0.708 |
FGFR3 |
0.680 | -0.079 | 3 | 0.717 |
SYK |
0.680 | 0.033 | -1 | 0.625 |
WEE1_TYR |
0.680 | -0.050 | -1 | 0.658 |
FYN |
0.679 | -0.033 | -1 | 0.597 |
PTK2 |
0.677 | 0.022 | -1 | 0.605 |
MATK |
0.677 | -0.068 | -1 | 0.650 |
EGFR |
0.677 | -0.035 | 1 | 0.661 |
LYN |
0.676 | -0.056 | 3 | 0.714 |
CSK |
0.675 | -0.056 | 2 | 0.740 |
EPHA2 |
0.673 | 0.011 | -1 | 0.681 |
FGFR4 |
0.672 | -0.056 | -1 | 0.677 |
CK1A |
0.671 | 0.019 | -3 | 0.444 |
MUSK |
0.671 | -0.026 | 1 | 0.634 |
SRC |
0.670 | -0.068 | -1 | 0.619 |
IGF1R |
0.670 | -0.044 | 3 | 0.636 |
CK1G2 |
0.668 | -0.035 | -3 | 0.489 |
ERBB4 |
0.666 | -0.021 | 1 | 0.681 |
FES |
0.658 | -0.027 | -1 | 0.574 |
ZAP70 |
0.650 | -0.052 | -1 | 0.554 |