Motif 685 (n=145)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4D2H0 | CTAGE15 | S140 | ochoa | cTAGE family member 15 (Protein cTAGE-15) | None |
| A4FU28 | CTAGE9 | S140 | ochoa | cTAGE family member 9 (Protein cTAGE-9) | None |
| B1AJZ9 | FHAD1 | S717 | ochoa | Forkhead-associated domain-containing protein 1 (FHA domain-containing protein 1) | Regulator of sperm motility and spermatocyte meiosis. {ECO:0000250|UniProtKB:A6PWD2}. |
| L7N2F9 | None | S75 | ochoa | V-SNARE coiled-coil homology domain-containing protein | None |
| O14974 | PPP1R12A | S292 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O15372 | EIF3H | S236 | ochoa | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O15498 | YKT6 | S172 | ochoa | Synaptobrevin homolog YKT6 (EC 2.3.1.-) | Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:9211930}. |
| O43156 | TTI1 | T804 | ochoa | TELO2-interacting protein 1 homolog (Protein SMG10) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650, ECO:0000269|PubMed:36724785}. |
| O43166 | SIPA1L1 | S286 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43707 | ACTN4 | S423 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60293 | ZFC3H1 | S381 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60303 | KATNIP | S915 | ochoa | Katanin-interacting protein | May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269|PubMed:26714646}. |
| O60343 | TBC1D4 | S1207 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60437 | PPL | S667 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O60711 | LPXN | S19 | ochoa | Leupaxin | Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}. |
| O75469 | NR1I2 | S200 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| O76003 | GLRX3 | S120 | ochoa | Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) | Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250|UniProtKB:Q9CQM9, ECO:0000269|PubMed:23615448, ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}. |
| O76024 | WFS1 | S235 | ochoa|psp | Wolframin | Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (PubMed:16989814). Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (PubMed:23035048). {ECO:0000269|PubMed:16989814, ECO:0000269|PubMed:23035048}. |
| O95613 | PCNT | S1653 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P08238 | HSP90AB1 | S460 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P09874 | PARP1 | S537 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0CG41 | CTAGE8 | S140 | ochoa | cTAGE family member 8 (Protein cTAGE-8) | None |
| P11055 | MYH3 | T1374 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11532 | DMD | S2993 | ochoa | Dystrophin | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}. |
| P12270 | TPR | S1495 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12814 | ACTN1 | S404 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12882 | MYH1 | T1377 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | T1373 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1412 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | T1375 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | T1376 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14625 | HSP90B1 | S515 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P15924 | DSP | S1659 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P17676 | CEBPB | S325 | psp | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
| P21127 | CDK11B | S434 | ochoa | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P23588 | EIF4B | S131 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P26038 | MSN | S429 | ochoa | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
| P29692 | EEF1D | S106 | ochoa | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
| P30533 | LRPAP1 | S310 | ochoa | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}. |
| P35270 | SPR | S213 | ochoa|psp | Sepiapterin reductase (SPR) (EC 1.1.1.153) | Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. |
| P35579 | MYH9 | T1058 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35609 | ACTN2 | S411 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35749 | MYH11 | S883 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P38646 | HSPA9 | S627 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P39023 | RPL3 | S372 | ochoa | Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P48788 | TNNI2 | S57 | ochoa | Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P49585 | PCYT1A | S233 | ochoa | Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) | Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:30559292, ECO:0000269|PubMed:7918629}. |
| P63027 | VAMP2 | S75 | ochoa | Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2) | Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63044, ECO:0000250|UniProtKB:P63045, ECO:0000269|PubMed:30929742}. |
| P81274 | GPSM2 | S408 | ochoa|psp | G-protein-signaling modulator 2 (Mosaic protein LGN) | Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Also plays an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity). {ECO:0000250|UniProtKB:Q8VDU0, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22327364}. |
| Q02241 | KIF23 | S605 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q08043 | ACTN3 | S418 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q12972 | PPP1R8 | S178 | ochoa | Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)] | Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.; FUNCTION: Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing. |
| Q13137 | CALCOCO2 | S315 | ochoa | Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52) | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:25771791}. |
| Q13492 | PICALM | S307 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q13625 | TP53BP2 | S296 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q13813 | SPTAN1 | S1322 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13813 | SPTAN1 | S2141 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14202 | ZMYM3 | S957 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14203 | DCTN1 | S417 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14789 | GOLGB1 | S869 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14789 | GOLGB1 | S1966 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14980 | NUMA1 | S388 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14980 | NUMA1 | S1438 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14980 | NUMA1 | S1601 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15075 | EEA1 | S351 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| Q15836 | VAMP3 | S58 | ochoa | Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| Q16891 | IMMT | S307 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q16891 | IMMT | S583 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q2M1P5 | KIF7 | S1280 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
| Q5JRA6 | MIA3 | S1539 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5M775 | SPECC1 | S241 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T0W9 | FAM83B | S780 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5VUB5 | FAM171A1 | S422 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q676U5 | ATG16L1 | S139 | psp | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
| Q69YN4 | VIRMA | S1464 | ochoa | Protein virilizer homolog | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| Q6DN90 | IQSEC1 | S103 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q76FK4 | NOL8 | S432 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7Z3T8 | ZFYVE16 | S317 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z406 | MYH14 | S1461 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q7Z7B0 | FILIP1 | S138 | ochoa | Filamin-A-interacting protein 1 (FILIP) | By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}. |
| Q86UF2 | CTAGE6 | S140 | ochoa | cTAGE family member 6 (Protein cTAGE-6) | None |
| Q8IX94 | CTAGE4 | S140 | ochoa | cTAGE family member 4 (Protein cTAGE-4) | Tumor-associated antigen. |
| Q8N371 | KDM8 | S361 | psp | Bifunctional peptidase and arginyl-hydroxylase JMJD5 (EC 1.14.11.73) (EC 3.4.-.-) (JmjC domain-containing protein 5) (Jumonji C domain-containing protein 5) (L-arginine (3R)-hydroxylase KDM8) | Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (PubMed:28847961, PubMed:28982940, PubMed:29459673, PubMed:29563586). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961, PubMed:28982940, PubMed:29459673). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961, PubMed:29459673). Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). Additionally, acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established (PubMed:29563586). Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition (PubMed:24740926). Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation (PubMed:20457893). Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (PubMed:28455245). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a catalytically-independent manner (PubMed:30500822). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822). {ECO:0000250|UniProtKB:Q9CXT6, ECO:0000269|PubMed:20457893, ECO:0000269|PubMed:24740926, ECO:0000269|PubMed:24981860, ECO:0000269|PubMed:28455245, ECO:0000269|PubMed:28847961, ECO:0000269|PubMed:28982940, ECO:0000269|PubMed:29459673, ECO:0000269|PubMed:29563586, ECO:0000269|PubMed:30500822}. |
| Q8N4C6 | NIN | S1524 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N4C6 | NIN | S1538 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N4C6 | NIN | S1783 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N4Y2 | CRACR2B | S307 | ochoa | EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) | Plays a role in store-operated Ca(2+) entry (SOCE). {ECO:0000269|PubMed:20418871}. |
| Q8N9T8 | KRI1 | S136 | ochoa | Protein KRI1 homolog | None |
| Q8NB16 | MLKL | S373 | ochoa | Mixed lineage kinase domain-like protein (hMLKL) | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610). {ECO:0000250|UniProtKB:Q9D2Y4, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:29883610}. |
| Q8NBJ4 | GOLM1 | S86 | ochoa | Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) | Unknown. Cellular response protein to viral infection. |
| Q8NCF5 | NFATC2IP | S231 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NFT2 | STEAP2 | S197 | ochoa | Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1) | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). {ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8BWB6}. |
| Q8TDY2 | RB1CC1 | S1051 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TEA7 | TBCK | S416 | ochoa | TBC domain-containing protein kinase-like protein (FERRY endosomal RAB5 effector complex subunit 1) (Fy-1) | Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) (PubMed:37267905). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (PubMed:37267905). Also involved in the modulation of mTOR signaling and expression of mTOR complex components (PubMed:23977024, PubMed:27040691). Involved in the control of actin-cytoskeleton organization (PubMed:23977024). {ECO:0000269|PubMed:23977024, ECO:0000269|PubMed:24576458, ECO:0000269|PubMed:27040691, ECO:0000269|PubMed:37267905}. |
| Q8WVV4 | POF1B | S413 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q96MH2 | HEXIM2 | S225 | ochoa | Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}. |
| Q96PC5 | MIA2 | S747 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96RF0 | SNX18 | S20 | ochoa | Sorting nexin-18 (SH3 and PX domain-containing protein 3B) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis (PubMed:18411244, PubMed:20427313, PubMed:21048941, PubMed:22718350). Required for efficient progress through mitosis and cytokinesis (PubMed:22718350). Required for normal formation of the cleavage furrow at the end of mitosis (PubMed:22718350). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis (PubMed:20427313). Plays a role in macropinocytosis (PubMed:21048941). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation (PubMed:18411244). Stimulates the GTPase activity of DNM2 (PubMed:20427313). Promotes DNM2 location at the plasma membrane (PubMed:20427313). Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A (PubMed:29437695). {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350, ECO:0000269|PubMed:29437695}. |
| Q9BPX7 | C7orf25 | S210 | ochoa | UPF0415 protein C7orf25 | None |
| Q9BQS8 | FYCO1 | S342 | ochoa | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
| Q9BRV8 | SIKE1 | S185 | ochoa|psp | Suppressor of IKBKE 1 (Suppressor of IKK-epsilon) | Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (PubMed:16281057). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:30622739). {ECO:0000269|PubMed:16281057, ECO:0000269|PubMed:30622739}. |
| Q9BVJ6 | UTP14A | S458 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BW19 | KIFC1 | S33 | ochoa|psp | Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET) | Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9QWT9, ECO:0000269|PubMed:15843429}. |
| Q9BW71 | HIRIP3 | T471 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BY89 | KIAA1671 | S1271 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYW2 | SETD2 | S262 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9H2W6 | MRPL46 | S85 | ochoa | Large ribosomal subunit protein mL46 (39S ribosomal protein L46, mitochondrial) (L46mt) (MRP-L46) (P2ECSL) | None |
| Q9H6N6 | MYH16 | T536 | ochoa | Putative uncharacterized protein MYH16 (Myosin heavy chain 16 pseudogene) (myosin heavy polypeptide 5) | Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes. {ECO:0000303|PubMed:15042088}. |
| Q9H799 | CPLANE1 | S162 | ochoa | Ciliogenesis and planar polarity effector 1 (Protein JBTS17) | Involved in ciliogenesis (PubMed:25877302, PubMed:35582950). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). {ECO:0000250|UniProtKB:Q8CE72, ECO:0000269|PubMed:35582950, ECO:0000305|PubMed:25877302}. |
| Q9NRA8 | EIF4ENIF1 | S414 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NWQ8 | PAG1 | S171 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NZ52 | GGA3 | S267 | psp | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
| Q9P2E9 | RRBP1 | S997 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9UEU0 | VTI1B | S179 | ochoa | Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1) | V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. {ECO:0000269|PubMed:23217709}. |
| Q9UJY4 | GGA2 | S284 | ochoa | ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}. |
| Q9UJY5 | GGA1 | S268 | ochoa|psp | ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712, PubMed:15886016). {ECO:0000250|UniProtKB:Q8R0H9, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:27901063}. |
| Q9UKX2 | MYH2 | T1379 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | T1377 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9ULI0 | ATAD2B | S1347 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9ULT0 | TTC7A | S697 | ochoa | Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. |
| Q9UMZ2 | SYNRG | S557 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UQ88 | CDK11A | S422 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y3L3 | SH3BP1 | S243 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y4B5 | MTCL1 | S653 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y520 | PRRC2C | S500 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y623 | MYH4 | T1377 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6K9 | IKBKG | S196 | ochoa | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
| P07900 | HSP90AA1 | S468 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| Q13439 | GOLGA4 | S1190 | Sugiyama | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| P17535 | JUND | S315 | Sugiyama | Transcription factor JunD (Transcription factor AP-1 subunit JunD) | Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:28981703, PubMed:9989505). {ECO:0000269|PubMed:28981703, ECO:0000269|PubMed:9989505}. |
| Q15776 | ZKSCAN8 | S141 | PSP | Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192) | May be involved in transcriptional regulation. |
| O60610 | DIAPH1 | S542 | Sugiyama | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| Q4V328 | GRIPAP1 | Y25 | Sugiyama | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q9Y4L1 | HYOU1 | Y755 | Sugiyama | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
| Q9P2B4 | CTTNBP2NL | Y134 | Sugiyama | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| P41252 | IARS1 | S271 | Sugiyama | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
| Q14980 | NUMA1 | S861 | Sugiyama | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| P35579 | MYH9 | S876 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| Q14980 | NUMA1 | S1183 | Sugiyama | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q16526 | CRY1 | S71 | SIGNOR | Cryptochrome-1 | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-BMAL1 independently of PER proteins and is found at CLOCK-BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Inhibits hepatic gluconeogenesis by decreasing nuclear FOXO1 levels that down-regulates gluconeogenic gene expression (By similarity). Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4 (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Plays an essential role in the generation of circadian rhythms in the retina (By similarity). Represses the transcriptional activity of NR1I2 (By similarity). {ECO:0000250|UniProtKB:P97784, ECO:0000269|PubMed:10531061, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:22170608, ECO:0000269|PubMed:23133559, ECO:0000269|PubMed:28388406}. |
| Q14980 | NUMA1 | S1162 | Sugiyama | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q9Y6D9 | MAD1L1 | S485 | Sugiyama | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| Q9GZM8 | NDEL1 | S95 | PSP | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| O94992 | HEXIM1 | S299 | Sugiyama | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| P12270 | TPR | S111 | Sugiyama | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-390522 | Striated Muscle Contraction | 1.377206e-07 | 6.861 |
| R-HSA-373753 | Nephrin family interactions | 4.719787e-06 | 5.326 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.039043e-05 | 4.691 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.031297e-05 | 4.692 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.837241e-05 | 4.416 |
| R-HSA-199991 | Membrane Trafficking | 6.760099e-05 | 4.170 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.530320e-04 | 3.815 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.530320e-04 | 3.815 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.136093e-04 | 3.504 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.324807e-04 | 3.364 |
| R-HSA-373755 | Semaphorin interactions | 6.163273e-04 | 3.210 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.104987e-03 | 2.957 |
| R-HSA-380287 | Centrosome maturation | 1.229739e-03 | 2.910 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.426392e-03 | 2.846 |
| R-HSA-397014 | Muscle contraction | 1.741246e-03 | 2.759 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.806795e-03 | 2.743 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 2.076551e-03 | 2.683 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.306021e-03 | 2.481 |
| R-HSA-69275 | G2/M Transition | 3.533121e-03 | 2.452 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.723587e-03 | 2.429 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.933841e-03 | 2.405 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 4.160122e-03 | 2.381 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.042007e-03 | 2.297 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 5.305550e-03 | 2.275 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.099731e-03 | 2.215 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 5.917228e-03 | 2.228 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 6.901927e-03 | 2.161 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 9.076698e-03 | 2.042 |
| R-HSA-9020591 | Interleukin-12 signaling | 8.593998e-03 | 2.066 |
| R-HSA-9659379 | Sensory processing of sound | 9.678414e-03 | 2.014 |
| R-HSA-2262752 | Cellular responses to stress | 9.484797e-03 | 2.023 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.013041e-02 | 1.994 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.026406e-02 | 1.989 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.151630e-02 | 1.939 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.167652e-02 | 1.933 |
| R-HSA-8854214 | TBC/RABGAPs | 1.284449e-02 | 1.891 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.345279e-02 | 1.871 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.392221e-02 | 1.856 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.417206e-02 | 1.849 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.421020e-02 | 1.847 |
| R-HSA-68877 | Mitotic Prometaphase | 1.589148e-02 | 1.799 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.714816e-02 | 1.766 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.831914e-02 | 1.737 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.905699e-02 | 1.720 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.847146e-02 | 1.733 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.805367e-02 | 1.743 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.919332e-02 | 1.717 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.967849e-02 | 1.706 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.037661e-02 | 1.691 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.053967e-02 | 1.687 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.324611e-02 | 1.634 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.419215e-02 | 1.616 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 2.792308e-02 | 1.554 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 2.792308e-02 | 1.554 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.705755e-02 | 1.431 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.705755e-02 | 1.431 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.705755e-02 | 1.431 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.705755e-02 | 1.431 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.705755e-02 | 1.431 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.705755e-02 | 1.431 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.705755e-02 | 1.431 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.705755e-02 | 1.431 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.705755e-02 | 1.431 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.705755e-02 | 1.431 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.705755e-02 | 1.431 |
| R-HSA-429947 | Deadenylation of mRNA | 3.312907e-02 | 1.480 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.027725e-02 | 1.519 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.027725e-02 | 1.519 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.359582e-02 | 1.474 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.768114e-02 | 1.558 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.590905e-02 | 1.445 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.768114e-02 | 1.558 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.551917e-02 | 1.450 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.551917e-02 | 1.450 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.480879e-02 | 1.605 |
| R-HSA-9612973 | Autophagy | 2.534734e-02 | 1.596 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.921160e-02 | 1.534 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.153301e-02 | 1.501 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.304640e-02 | 1.481 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.723897e-02 | 1.429 |
| R-HSA-68886 | M Phase | 3.826139e-02 | 1.417 |
| R-HSA-8949613 | Cristae formation | 3.936354e-02 | 1.405 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.936354e-02 | 1.405 |
| R-HSA-3371556 | Cellular response to heat stress | 3.987304e-02 | 1.399 |
| R-HSA-168255 | Influenza Infection | 4.057158e-02 | 1.392 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.077523e-02 | 1.390 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.204129e-02 | 1.376 |
| R-HSA-5694530 | Cargo concentration in the ER | 4.830194e-02 | 1.316 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.600333e-02 | 1.337 |
| R-HSA-114608 | Platelet degranulation | 4.645789e-02 | 1.333 |
| R-HSA-1640170 | Cell Cycle | 4.419275e-02 | 1.355 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.064158e-02 | 1.295 |
| R-HSA-977225 | Amyloid fiber formation | 5.286872e-02 | 1.277 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.302129e-02 | 1.276 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.361252e-02 | 1.271 |
| R-HSA-5250982 | Toxicity of tetanus toxin (tetX) | 5.507145e-02 | 1.259 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 6.395246e-02 | 1.194 |
| R-HSA-8875656 | MET receptor recycling | 9.865489e-02 | 1.006 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.320789e-01 | 0.879 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.402407e-01 | 0.853 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.876347e-01 | 0.727 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.876347e-01 | 0.727 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.103490e-01 | 0.677 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.177794e-01 | 0.662 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.177794e-01 | 0.662 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.251403e-01 | 0.648 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.251403e-01 | 0.648 |
| R-HSA-72649 | Translation initiation complex formation | 1.168013e-01 | 0.933 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.229957e-01 | 0.910 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.816029e-01 | 0.550 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.979515e-02 | 1.098 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.227477e-01 | 0.652 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.227477e-01 | 0.652 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.435573e-01 | 0.613 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.470353e-01 | 0.607 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.609622e-01 | 0.583 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.609251e-01 | 0.583 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.808891e-02 | 1.167 |
| R-HSA-9646399 | Aggrephagy | 7.339052e-02 | 1.134 |
| R-HSA-156902 | Peptide chain elongation | 2.331379e-01 | 0.632 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.402407e-01 | 0.853 |
| R-HSA-9857492 | Protein lipoylation | 1.642714e-01 | 0.784 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.647571e-01 | 0.577 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.644461e-01 | 0.578 |
| R-HSA-6783984 | Glycine degradation | 1.799199e-01 | 0.745 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.300337e-02 | 1.137 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.609251e-01 | 0.583 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 7.275054e-02 | 1.138 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.644461e-01 | 0.578 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 7.608982e-02 | 1.119 |
| R-HSA-72766 | Translation | 1.351235e-01 | 0.869 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 7.275054e-02 | 1.138 |
| R-HSA-192905 | vRNP Assembly | 1.238402e-01 | 0.907 |
| R-HSA-192814 | vRNA Synthesis | 1.238402e-01 | 0.907 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.320789e-01 | 0.879 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.402407e-01 | 0.853 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.642714e-01 | 0.784 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.642714e-01 | 0.784 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.952774e-01 | 0.709 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.177794e-01 | 0.662 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.468126e-01 | 0.608 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.292683e-01 | 0.889 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.678826e-01 | 0.572 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.816029e-01 | 0.550 |
| R-HSA-203615 | eNOS activation | 5.789713e-02 | 1.237 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.718784e-02 | 1.173 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.089575e-01 | 0.680 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 9.581367e-02 | 1.019 |
| R-HSA-3371511 | HSF1 activation | 6.292204e-02 | 1.201 |
| R-HSA-9620244 | Long-term potentiation | 2.539020e-01 | 0.595 |
| R-HSA-3295583 | TRP channels | 2.609251e-01 | 0.583 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 6.808883e-02 | 1.167 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 9.010100e-02 | 1.045 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.324323e-01 | 0.634 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.396562e-01 | 0.620 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.324324e-01 | 0.878 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.483263e-01 | 0.829 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.609251e-01 | 0.583 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 6.808883e-02 | 1.167 |
| R-HSA-9711097 | Cellular response to starvation | 8.641686e-02 | 1.063 |
| R-HSA-446107 | Type I hemidesmosome assembly | 9.865489e-02 | 1.006 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.642714e-01 | 0.784 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.028486e-01 | 0.693 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.177794e-01 | 0.662 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.468126e-01 | 0.608 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.468126e-01 | 0.608 |
| R-HSA-1632852 | Macroautophagy | 6.364056e-02 | 1.196 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 1.402407e-01 | 0.853 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.563362e-01 | 0.806 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 2.678826e-01 | 0.572 |
| R-HSA-983189 | Kinesins | 1.356141e-01 | 0.868 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.721324e-01 | 0.764 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.952774e-01 | 0.709 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.609251e-01 | 0.583 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.679301e-01 | 0.572 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.485059e-01 | 0.828 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.320789e-01 | 0.879 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.402407e-01 | 0.853 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.402407e-01 | 0.853 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.563362e-01 | 0.806 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.251403e-01 | 0.648 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.076678e-01 | 0.968 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.816029e-01 | 0.550 |
| R-HSA-9663891 | Selective autophagy | 2.331379e-01 | 0.632 |
| R-HSA-5218859 | Regulated Necrosis | 1.616338e-01 | 0.791 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 9.010100e-02 | 1.045 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.028486e-01 | 0.693 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.651037e-01 | 0.782 |
| R-HSA-5250989 | Toxicity of botulinum toxin type G (botG) | 6.395246e-02 | 1.194 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 7.275054e-02 | 1.138 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 8.146646e-02 | 1.089 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 8.146646e-02 | 1.089 |
| R-HSA-5250958 | Toxicity of botulinum toxin type B (botB) | 9.865489e-02 | 1.006 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.155237e-01 | 0.937 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.238402e-01 | 0.907 |
| R-HSA-3371568 | Attenuation phase | 7.339052e-02 | 1.134 |
| R-HSA-9629569 | Protein hydroxylation | 2.103490e-01 | 0.677 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.251403e-01 | 0.648 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.678826e-01 | 0.572 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.952774e-01 | 0.709 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.850723e-01 | 0.733 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.366083e-01 | 0.626 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.679301e-01 | 0.572 |
| R-HSA-201451 | Signaling by BMP | 2.678826e-01 | 0.572 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.356141e-01 | 0.868 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 7.275054e-02 | 1.138 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.876347e-01 | 0.727 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.678826e-01 | 0.572 |
| R-HSA-8978934 | Metabolism of cofactors | 1.716136e-01 | 0.765 |
| R-HSA-622312 | Inflammasomes | 2.747750e-01 | 0.561 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.747750e-01 | 0.561 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.419723e-01 | 0.616 |
| R-HSA-392499 | Metabolism of proteins | 2.070350e-01 | 0.684 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 1.071289e-01 | 0.970 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 2.324323e-01 | 0.634 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.324323e-01 | 0.634 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.364056e-02 | 1.196 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 2.124125e-01 | 0.673 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.238402e-01 | 0.907 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 2.324323e-01 | 0.634 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.195312e-01 | 0.659 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.705283e-02 | 1.060 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 9.865489e-02 | 1.006 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.071289e-01 | 0.970 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.483263e-01 | 0.829 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.642714e-01 | 0.784 |
| R-HSA-9865881 | Complex III assembly | 2.468126e-01 | 0.608 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.420282e-01 | 0.848 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.799199e-01 | 0.745 |
| R-HSA-180292 | GAB1 signalosome | 1.952774e-01 | 0.709 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.470911e-01 | 0.607 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.251403e-01 | 0.648 |
| R-HSA-5357801 | Programmed Cell Death | 6.317661e-02 | 1.199 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.324323e-01 | 0.634 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.110693e-01 | 0.954 |
| R-HSA-3000170 | Syndecan interactions | 2.396562e-01 | 0.620 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.539020e-01 | 0.595 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 9.602917e-02 | 1.018 |
| R-HSA-422475 | Axon guidance | 8.901528e-02 | 1.051 |
| R-HSA-177929 | Signaling by EGFR | 1.229957e-01 | 0.910 |
| R-HSA-9675108 | Nervous system development | 1.185477e-01 | 0.926 |
| R-HSA-449836 | Other interleukin signaling | 2.028486e-01 | 0.693 |
| R-HSA-264876 | Insulin processing | 2.678826e-01 | 0.572 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.766261e-01 | 0.753 |
| R-HSA-75153 | Apoptotic execution phase | 9.291268e-02 | 1.032 |
| R-HSA-449147 | Signaling by Interleukins | 1.588273e-01 | 0.799 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.702192e-01 | 0.568 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 9.874041e-02 | 1.006 |
| R-HSA-9007101 | Rab regulation of trafficking | 1.278365e-01 | 0.893 |
| R-HSA-109581 | Apoptosis | 2.420783e-01 | 0.616 |
| R-HSA-1500931 | Cell-Cell communication | 1.000251e-01 | 1.000 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.300337e-02 | 1.137 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 7.072324e-02 | 1.150 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.818621e-01 | 0.550 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.853426e-01 | 0.545 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.883669e-01 | 0.540 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.883669e-01 | 0.540 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.883669e-01 | 0.540 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.883669e-01 | 0.540 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.883669e-01 | 0.540 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.888215e-01 | 0.539 |
| R-HSA-2559583 | Cellular Senescence | 2.902457e-01 | 0.537 |
| R-HSA-192823 | Viral mRNA Translation | 2.922986e-01 | 0.534 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.950677e-01 | 0.530 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.950677e-01 | 0.530 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.950677e-01 | 0.530 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.017058e-01 | 0.520 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.020667e-01 | 0.520 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.082818e-01 | 0.511 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.082818e-01 | 0.511 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.082818e-01 | 0.511 |
| R-HSA-9930044 | Nuclear RNA decay | 3.082818e-01 | 0.511 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.096470e-01 | 0.509 |
| R-HSA-211000 | Gene Silencing by RNA | 3.096470e-01 | 0.509 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 3.107690e-01 | 0.508 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.131075e-01 | 0.504 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.147963e-01 | 0.502 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.147963e-01 | 0.502 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.147963e-01 | 0.502 |
| R-HSA-5617833 | Cilium Assembly | 3.159097e-01 | 0.500 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.165644e-01 | 0.500 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.184808e-01 | 0.497 |
| R-HSA-202403 | TCR signaling | 3.200173e-01 | 0.495 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.210524e-01 | 0.493 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.212498e-01 | 0.493 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.212498e-01 | 0.493 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.212498e-01 | 0.493 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.269108e-01 | 0.486 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.269108e-01 | 0.486 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.276430e-01 | 0.485 |
| R-HSA-381042 | PERK regulates gene expression | 3.276430e-01 | 0.485 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.276430e-01 | 0.485 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.339763e-01 | 0.476 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.339763e-01 | 0.476 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.402503e-01 | 0.468 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.402503e-01 | 0.468 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.402503e-01 | 0.468 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.406412e-01 | 0.468 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.464657e-01 | 0.460 |
| R-HSA-373760 | L1CAM interactions | 3.474749e-01 | 0.459 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.508832e-01 | 0.455 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.526228e-01 | 0.453 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.526228e-01 | 0.453 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.587223e-01 | 0.445 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.587223e-01 | 0.445 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.587223e-01 | 0.445 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.587223e-01 | 0.445 |
| R-HSA-5260271 | Diseases of Immune System | 3.587223e-01 | 0.445 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.587223e-01 | 0.445 |
| R-HSA-68875 | Mitotic Prophase | 3.610713e-01 | 0.442 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.644545e-01 | 0.438 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.647648e-01 | 0.438 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.647648e-01 | 0.438 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.647648e-01 | 0.438 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.647648e-01 | 0.438 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.647648e-01 | 0.438 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.707506e-01 | 0.431 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.707506e-01 | 0.431 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 3.707506e-01 | 0.431 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.707506e-01 | 0.431 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.712006e-01 | 0.430 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.712006e-01 | 0.430 |
| R-HSA-6809371 | Formation of the cornified envelope | 3.745631e-01 | 0.426 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.766805e-01 | 0.424 |
| R-HSA-165159 | MTOR signalling | 3.766805e-01 | 0.424 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.774963e-01 | 0.423 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.941389e-01 | 0.404 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.998498e-01 | 0.398 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.998498e-01 | 0.398 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.998498e-01 | 0.398 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.998498e-01 | 0.398 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.998498e-01 | 0.398 |
| R-HSA-9843745 | Adipogenesis | 4.044826e-01 | 0.393 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.055071e-01 | 0.392 |
| R-HSA-437239 | Recycling pathway of L1 | 4.055071e-01 | 0.392 |
| R-HSA-1483191 | Synthesis of PC | 4.055071e-01 | 0.392 |
| R-HSA-9909396 | Circadian clock | 4.077662e-01 | 0.390 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.111115e-01 | 0.386 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 4.166634e-01 | 0.380 |
| R-HSA-72312 | rRNA processing | 4.254943e-01 | 0.371 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.272810e-01 | 0.369 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.276117e-01 | 0.369 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.305012e-01 | 0.366 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.330090e-01 | 0.364 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.330090e-01 | 0.364 |
| R-HSA-9664407 | Parasite infection | 4.369132e-01 | 0.360 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.369132e-01 | 0.360 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.369132e-01 | 0.360 |
| R-HSA-8939211 | ESR-mediated signaling | 4.379285e-01 | 0.359 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.383558e-01 | 0.358 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.488995e-01 | 0.348 |
| R-HSA-75893 | TNF signaling | 4.540974e-01 | 0.343 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.540974e-01 | 0.343 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.540974e-01 | 0.343 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.592466e-01 | 0.338 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.592466e-01 | 0.338 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.694007e-01 | 0.328 |
| R-HSA-191859 | snRNP Assembly | 4.694007e-01 | 0.328 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.694007e-01 | 0.328 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.714644e-01 | 0.327 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.714644e-01 | 0.327 |
| R-HSA-6798695 | Neutrophil degranulation | 4.716233e-01 | 0.326 |
| R-HSA-379724 | tRNA Aminoacylation | 4.744064e-01 | 0.324 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.776109e-01 | 0.321 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.793653e-01 | 0.319 |
| R-HSA-450294 | MAP kinase activation | 4.793653e-01 | 0.319 |
| R-HSA-9609507 | Protein localization | 4.806679e-01 | 0.318 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.837141e-01 | 0.315 |
| R-HSA-1268020 | Mitochondrial protein import | 4.842777e-01 | 0.315 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.842777e-01 | 0.315 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.842777e-01 | 0.315 |
| R-HSA-6799198 | Complex I biogenesis | 4.891440e-01 | 0.311 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.891440e-01 | 0.311 |
| R-HSA-1266738 | Developmental Biology | 4.950132e-01 | 0.305 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.017589e-01 | 0.300 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.034709e-01 | 0.298 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.135634e-01 | 0.289 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.219545e-01 | 0.282 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.219545e-01 | 0.282 |
| R-HSA-448424 | Interleukin-17 signaling | 5.219545e-01 | 0.282 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.219545e-01 | 0.282 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.264675e-01 | 0.279 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.264675e-01 | 0.279 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.309382e-01 | 0.275 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 5.309382e-01 | 0.275 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.309382e-01 | 0.275 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.353670e-01 | 0.271 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.421816e-01 | 0.266 |
| R-HSA-9658195 | Leishmania infection | 5.421816e-01 | 0.266 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5.441003e-01 | 0.264 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.441003e-01 | 0.264 |
| R-HSA-917937 | Iron uptake and transport | 5.441003e-01 | 0.264 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.478633e-01 | 0.261 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.550146e-01 | 0.256 |
| R-HSA-8953854 | Metabolism of RNA | 5.622377e-01 | 0.250 |
| R-HSA-6806834 | Signaling by MET | 5.652268e-01 | 0.248 |
| R-HSA-9833482 | PKR-mediated signaling | 5.652268e-01 | 0.248 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.734024e-01 | 0.242 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.814253e-01 | 0.236 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.853803e-01 | 0.233 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.890343e-01 | 0.230 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 5.931794e-01 | 0.227 |
| R-HSA-162582 | Signal Transduction | 5.966798e-01 | 0.224 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.970241e-01 | 0.224 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.008327e-01 | 0.221 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.083429e-01 | 0.216 |
| R-HSA-202424 | Downstream TCR signaling | 6.083429e-01 | 0.216 |
| R-HSA-73884 | Base Excision Repair | 6.083429e-01 | 0.216 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.211889e-01 | 0.207 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.265101e-01 | 0.203 |
| R-HSA-1474290 | Collagen formation | 6.265101e-01 | 0.203 |
| R-HSA-597592 | Post-translational protein modification | 6.289419e-01 | 0.201 |
| R-HSA-6805567 | Keratinization | 6.308888e-01 | 0.200 |
| R-HSA-9679506 | SARS-CoV Infections | 6.367362e-01 | 0.196 |
| R-HSA-5389840 | Mitochondrial translation elongation | 6.370059e-01 | 0.196 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.370059e-01 | 0.196 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.404390e-01 | 0.194 |
| R-HSA-5368286 | Mitochondrial translation initiation | 6.438398e-01 | 0.191 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.438398e-01 | 0.191 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.438398e-01 | 0.191 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.438398e-01 | 0.191 |
| R-HSA-422356 | Regulation of insulin secretion | 6.438398e-01 | 0.191 |
| R-HSA-1474244 | Extracellular matrix organization | 6.461034e-01 | 0.190 |
| R-HSA-70171 | Glycolysis | 6.505458e-01 | 0.187 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.505458e-01 | 0.187 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.538517e-01 | 0.185 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.538517e-01 | 0.185 |
| R-HSA-68882 | Mitotic Anaphase | 6.542967e-01 | 0.184 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.565717e-01 | 0.183 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.571265e-01 | 0.182 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.571265e-01 | 0.182 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 6.603705e-01 | 0.180 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.635840e-01 | 0.178 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.699206e-01 | 0.174 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.699206e-01 | 0.174 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.730443e-01 | 0.172 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.792040e-01 | 0.168 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.792040e-01 | 0.168 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.792040e-01 | 0.168 |
| R-HSA-5419276 | Mitochondrial translation termination | 6.822404e-01 | 0.166 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.822404e-01 | 0.166 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.852483e-01 | 0.164 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.852483e-01 | 0.164 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.911795e-01 | 0.160 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.941033e-01 | 0.159 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.969996e-01 | 0.157 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.033569e-01 | 0.153 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.055261e-01 | 0.151 |
| R-HSA-70326 | Glucose metabolism | 7.110775e-01 | 0.148 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.110775e-01 | 0.148 |
| R-HSA-5693538 | Homology Directed Repair | 7.138142e-01 | 0.146 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.165250e-01 | 0.145 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.165250e-01 | 0.145 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.245055e-01 | 0.140 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.245055e-01 | 0.140 |
| R-HSA-168256 | Immune System | 7.252679e-01 | 0.140 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.297014e-01 | 0.137 |
| R-HSA-194138 | Signaling by VEGF | 7.348000e-01 | 0.134 |
| R-HSA-168249 | Innate Immune System | 7.365470e-01 | 0.133 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.399223e-01 | 0.131 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.422692e-01 | 0.129 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.474787e-01 | 0.126 |
| R-HSA-163685 | Integration of energy metabolism | 7.656894e-01 | 0.116 |
| R-HSA-5368287 | Mitochondrial translation | 7.701132e-01 | 0.113 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.701132e-01 | 0.113 |
| R-HSA-446728 | Cell junction organization | 7.739600e-01 | 0.111 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.755560e-01 | 0.110 |
| R-HSA-109582 | Hemostasis | 7.762023e-01 | 0.110 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.808132e-01 | 0.107 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.849533e-01 | 0.105 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.909855e-01 | 0.102 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.930018e-01 | 0.101 |
| R-HSA-166520 | Signaling by NTRKs | 7.930018e-01 | 0.101 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.007511e-01 | 0.097 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.012265e-01 | 0.096 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 8.026429e-01 | 0.095 |
| R-HSA-73887 | Death Receptor Signaling | 8.045169e-01 | 0.094 |
| R-HSA-9610379 | HCMV Late Events | 8.100335e-01 | 0.091 |
| R-HSA-162587 | HIV Life Cycle | 8.100335e-01 | 0.091 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.118378e-01 | 0.091 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.153954e-01 | 0.089 |
| R-HSA-212436 | Generic Transcription Pathway | 8.185227e-01 | 0.087 |
| R-HSA-5619102 | SLC transporter disorders | 8.273289e-01 | 0.082 |
| R-HSA-72306 | tRNA processing | 8.338007e-01 | 0.079 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.353806e-01 | 0.078 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.366949e-01 | 0.077 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.369456e-01 | 0.077 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.384958e-01 | 0.076 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.384958e-01 | 0.076 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.384958e-01 | 0.076 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.415525e-01 | 0.075 |
| R-HSA-112316 | Neuronal System | 8.432579e-01 | 0.074 |
| R-HSA-611105 | Respiratory electron transport | 8.460300e-01 | 0.073 |
| R-HSA-9824446 | Viral Infection Pathways | 8.555215e-01 | 0.068 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.569466e-01 | 0.067 |
| R-HSA-983712 | Ion channel transport | 8.613984e-01 | 0.065 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.633400e-01 | 0.064 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.678705e-01 | 0.062 |
| R-HSA-9609690 | HCMV Early Events | 8.703745e-01 | 0.060 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.752418e-01 | 0.058 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.787728e-01 | 0.056 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.787728e-01 | 0.056 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.797538e-01 | 0.056 |
| R-HSA-72172 | mRNA Splicing | 8.810715e-01 | 0.055 |
| R-HSA-1280218 | Adaptive Immune System | 8.827325e-01 | 0.054 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.898410e-01 | 0.051 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.953822e-01 | 0.048 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.967401e-01 | 0.047 |
| R-HSA-913531 | Interferon Signaling | 8.967401e-01 | 0.047 |
| R-HSA-162906 | HIV Infection | 9.045886e-01 | 0.044 |
| R-HSA-74160 | Gene expression (Transcription) | 9.080777e-01 | 0.042 |
| R-HSA-3247509 | Chromatin modifying enzymes | 9.107823e-01 | 0.041 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.212442e-01 | 0.036 |
| R-HSA-4839726 | Chromatin organization | 9.227418e-01 | 0.035 |
| R-HSA-9609646 | HCMV Infection | 9.234799e-01 | 0.035 |
| R-HSA-5688426 | Deubiquitination | 9.270667e-01 | 0.033 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.277638e-01 | 0.033 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.324614e-01 | 0.030 |
| R-HSA-5663205 | Infectious disease | 9.385215e-01 | 0.028 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.415302e-01 | 0.026 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.456529e-01 | 0.024 |
| R-HSA-1483257 | Phospholipid metabolism | 9.503534e-01 | 0.022 |
| R-HSA-1643685 | Disease | 9.681143e-01 | 0.014 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.681380e-01 | 0.014 |
| R-HSA-73894 | DNA Repair | 9.734814e-01 | 0.012 |
| R-HSA-418594 | G alpha (i) signalling events | 9.833385e-01 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.895465e-01 | 0.005 |
| R-HSA-211859 | Biological oxidations | 9.946126e-01 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 9.980981e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.993635e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.995453e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.998010e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999997e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MAPKAPK2 |
0.820 | 0.272 | -3 | 0.835 |
PRKD2 |
0.818 | 0.298 | -3 | 0.855 |
TSSK2 |
0.818 | 0.380 | -5 | 0.739 |
MAPKAPK3 |
0.816 | 0.264 | -3 | 0.849 |
PRKD1 |
0.814 | 0.328 | -3 | 0.841 |
CAMK1B |
0.814 | 0.264 | -3 | 0.871 |
RSK2 |
0.812 | 0.203 | -3 | 0.844 |
PRKD3 |
0.811 | 0.306 | -3 | 0.837 |
TSSK1 |
0.810 | 0.309 | -3 | 0.873 |
CAMK2A |
0.808 | 0.248 | 2 | 0.707 |
CAMK2B |
0.808 | 0.258 | 2 | 0.703 |
CAMK1D |
0.805 | 0.276 | -3 | 0.807 |
PIM1 |
0.804 | 0.177 | -3 | 0.855 |
P90RSK |
0.804 | 0.177 | -3 | 0.841 |
CHK1 |
0.803 | 0.313 | -3 | 0.855 |
CAMK2D |
0.803 | 0.196 | -3 | 0.847 |
PKN3 |
0.803 | 0.145 | -3 | 0.854 |
AMPKA1 |
0.803 | 0.205 | -3 | 0.869 |
CAMK4 |
0.802 | 0.210 | -3 | 0.856 |
PIM3 |
0.801 | 0.109 | -3 | 0.864 |
COT |
0.801 | 0.006 | 2 | 0.787 |
CAMK1G |
0.801 | 0.217 | -3 | 0.844 |
CLK3 |
0.800 | 0.094 | 1 | 0.786 |
SKMLCK |
0.800 | 0.118 | -2 | 0.811 |
NUAK2 |
0.799 | 0.165 | -3 | 0.878 |
AMPKA2 |
0.799 | 0.195 | -3 | 0.866 |
MELK |
0.798 | 0.213 | -3 | 0.857 |
PKN2 |
0.798 | 0.126 | -3 | 0.862 |
LATS2 |
0.798 | 0.098 | -5 | 0.516 |
GRK6 |
0.797 | 0.199 | 1 | 0.813 |
RSK3 |
0.797 | 0.131 | -3 | 0.846 |
CAMK2G |
0.797 | 0.092 | 2 | 0.745 |
P70S6KB |
0.796 | 0.121 | -3 | 0.859 |
CDC7 |
0.796 | 0.067 | 1 | 0.868 |
PAK1 |
0.796 | 0.119 | -2 | 0.756 |
DAPK2 |
0.796 | 0.162 | -3 | 0.857 |
CAMK1A |
0.795 | 0.271 | -3 | 0.800 |
CDKL1 |
0.795 | 0.117 | -3 | 0.841 |
CAMLCK |
0.795 | 0.121 | -2 | 0.815 |
PKACG |
0.795 | 0.126 | -2 | 0.762 |
MSK1 |
0.795 | 0.165 | -3 | 0.828 |
MYLK4 |
0.795 | 0.150 | -2 | 0.769 |
RSK4 |
0.795 | 0.159 | -3 | 0.822 |
NIK |
0.795 | 0.142 | -3 | 0.860 |
WNK1 |
0.795 | 0.097 | -2 | 0.803 |
MNK2 |
0.794 | 0.134 | -2 | 0.789 |
NDR2 |
0.794 | 0.055 | -3 | 0.847 |
MSK2 |
0.794 | 0.142 | -3 | 0.815 |
NDR1 |
0.794 | 0.070 | -3 | 0.864 |
SRPK1 |
0.793 | 0.111 | -3 | 0.827 |
ATR |
0.793 | 0.099 | 1 | 0.872 |
MOS |
0.792 | 0.047 | 1 | 0.866 |
DCAMKL2 |
0.792 | 0.178 | -3 | 0.877 |
MARK4 |
0.792 | 0.085 | 4 | 0.802 |
DCAMKL1 |
0.791 | 0.172 | -3 | 0.866 |
PKCD |
0.791 | 0.080 | 2 | 0.680 |
PKACB |
0.791 | 0.144 | -2 | 0.709 |
PRPK |
0.790 | -0.072 | -1 | 0.830 |
MNK1 |
0.790 | 0.130 | -2 | 0.808 |
CLK4 |
0.790 | 0.129 | -3 | 0.846 |
NUAK1 |
0.790 | 0.169 | -3 | 0.865 |
CLK1 |
0.789 | 0.134 | -3 | 0.844 |
AKT2 |
0.789 | 0.151 | -3 | 0.804 |
PRKX |
0.789 | 0.174 | -3 | 0.798 |
PAK3 |
0.789 | 0.079 | -2 | 0.758 |
HUNK |
0.789 | 0.024 | 2 | 0.772 |
SGK3 |
0.788 | 0.158 | -3 | 0.835 |
SSTK |
0.788 | 0.176 | 4 | 0.752 |
LATS1 |
0.787 | 0.109 | -3 | 0.845 |
RIPK3 |
0.787 | -0.006 | 3 | 0.536 |
PKG2 |
0.787 | 0.125 | -2 | 0.723 |
SRPK2 |
0.787 | 0.111 | -3 | 0.784 |
ATM |
0.786 | 0.122 | 1 | 0.854 |
RAF1 |
0.786 | -0.070 | 1 | 0.804 |
MAPKAPK5 |
0.786 | 0.136 | -3 | 0.802 |
CDKL5 |
0.785 | 0.082 | -3 | 0.835 |
AURC |
0.785 | 0.089 | -2 | 0.693 |
CLK2 |
0.785 | 0.135 | -3 | 0.849 |
SIK |
0.785 | 0.135 | -3 | 0.837 |
AURB |
0.785 | 0.096 | -2 | 0.688 |
FAM20C |
0.784 | 0.084 | 2 | 0.576 |
PKACA |
0.784 | 0.150 | -2 | 0.680 |
NLK |
0.784 | -0.002 | 1 | 0.729 |
PDHK4 |
0.784 | -0.105 | 1 | 0.804 |
QIK |
0.784 | 0.115 | -3 | 0.834 |
NIM1 |
0.784 | 0.046 | 3 | 0.590 |
QSK |
0.784 | 0.112 | 4 | 0.765 |
GRK5 |
0.784 | 0.024 | -3 | 0.745 |
BRSK1 |
0.784 | 0.098 | -3 | 0.860 |
ULK2 |
0.783 | -0.085 | 2 | 0.714 |
CHK2 |
0.783 | 0.211 | -3 | 0.781 |
BMPR2 |
0.783 | -0.133 | -2 | 0.804 |
WNK3 |
0.783 | -0.021 | 1 | 0.795 |
ICK |
0.782 | 0.069 | -3 | 0.855 |
PAK2 |
0.782 | 0.078 | -2 | 0.743 |
SBK |
0.782 | 0.218 | -3 | 0.737 |
MARK3 |
0.782 | 0.097 | 4 | 0.733 |
PAK6 |
0.782 | 0.115 | -2 | 0.705 |
IKKB |
0.782 | -0.035 | -2 | 0.693 |
CHAK2 |
0.782 | -0.029 | -1 | 0.854 |
SMMLCK |
0.782 | 0.136 | -3 | 0.854 |
PKCB |
0.781 | 0.057 | 2 | 0.628 |
RIPK1 |
0.781 | 0.003 | 1 | 0.804 |
PLK1 |
0.780 | 0.059 | -2 | 0.727 |
PIM2 |
0.780 | 0.108 | -3 | 0.833 |
AKT1 |
0.779 | 0.145 | -3 | 0.819 |
MARK2 |
0.779 | 0.091 | 4 | 0.700 |
SRPK3 |
0.779 | 0.081 | -3 | 0.802 |
MARK1 |
0.779 | 0.099 | 4 | 0.751 |
PKCG |
0.779 | 0.035 | 2 | 0.653 |
PKCH |
0.779 | 0.051 | 2 | 0.634 |
PDHK1 |
0.778 | -0.098 | 1 | 0.792 |
DAPK3 |
0.778 | 0.163 | -3 | 0.866 |
HIPK4 |
0.778 | 0.035 | 1 | 0.740 |
GCN2 |
0.777 | -0.150 | 2 | 0.700 |
P70S6K |
0.777 | 0.107 | -3 | 0.805 |
TBK1 |
0.777 | -0.084 | 1 | 0.681 |
DAPK1 |
0.777 | 0.166 | -3 | 0.849 |
ALK4 |
0.777 | 0.061 | -2 | 0.772 |
DSTYK |
0.777 | -0.105 | 2 | 0.752 |
PLK3 |
0.777 | 0.081 | 2 | 0.755 |
DLK |
0.777 | -0.046 | 1 | 0.789 |
BUB1 |
0.776 | 0.317 | -5 | 0.769 |
MST4 |
0.776 | -0.028 | 2 | 0.673 |
GRK1 |
0.775 | 0.047 | -2 | 0.702 |
TGFBR1 |
0.775 | 0.067 | -2 | 0.746 |
BRSK2 |
0.775 | 0.056 | -3 | 0.857 |
ULK1 |
0.775 | -0.089 | -3 | 0.726 |
PKR |
0.775 | -0.014 | 1 | 0.843 |
ERK5 |
0.775 | -0.014 | 1 | 0.670 |
TTBK2 |
0.774 | -0.034 | 2 | 0.709 |
IRE1 |
0.774 | -0.019 | 1 | 0.800 |
AURA |
0.774 | 0.064 | -2 | 0.649 |
DYRK2 |
0.774 | 0.044 | 1 | 0.596 |
MTOR |
0.774 | -0.133 | 1 | 0.692 |
SNRK |
0.773 | 0.006 | 2 | 0.678 |
TGFBR2 |
0.773 | -0.058 | -2 | 0.720 |
IKKE |
0.773 | -0.098 | 1 | 0.680 |
BMPR1B |
0.773 | 0.056 | 1 | 0.778 |
SGK1 |
0.773 | 0.158 | -3 | 0.751 |
CK2A2 |
0.773 | 0.275 | 1 | 0.715 |
MRCKA |
0.772 | 0.149 | -3 | 0.843 |
MLK1 |
0.772 | -0.128 | 2 | 0.702 |
PKN1 |
0.772 | 0.143 | -3 | 0.820 |
PKCZ |
0.772 | 0.011 | 2 | 0.669 |
MASTL |
0.772 | -0.128 | -2 | 0.748 |
PKCA |
0.771 | 0.013 | 2 | 0.614 |
GRK7 |
0.771 | 0.128 | 1 | 0.711 |
SMG1 |
0.771 | 0.076 | 1 | 0.843 |
ALK2 |
0.771 | 0.076 | -2 | 0.748 |
PHKG1 |
0.771 | 0.037 | -3 | 0.863 |
DNAPK |
0.771 | 0.099 | 1 | 0.759 |
DRAK1 |
0.770 | 0.008 | 1 | 0.720 |
IKKA |
0.769 | -0.022 | -2 | 0.670 |
ANKRD3 |
0.769 | -0.116 | 1 | 0.819 |
MEK1 |
0.769 | -0.056 | 2 | 0.770 |
MRCKB |
0.769 | 0.133 | -3 | 0.833 |
NEK7 |
0.769 | -0.170 | -3 | 0.734 |
GRK4 |
0.769 | -0.053 | -2 | 0.735 |
PASK |
0.768 | 0.087 | -3 | 0.845 |
NEK9 |
0.768 | -0.138 | 2 | 0.707 |
IRE2 |
0.768 | -0.027 | 2 | 0.685 |
BCKDK |
0.768 | -0.080 | -1 | 0.818 |
PHKG2 |
0.767 | 0.065 | -3 | 0.863 |
WNK4 |
0.767 | 0.031 | -2 | 0.777 |
DYRK1A |
0.767 | 0.070 | 1 | 0.637 |
NEK2 |
0.766 | -0.052 | 2 | 0.687 |
PKCT |
0.766 | 0.047 | 2 | 0.632 |
AKT3 |
0.766 | 0.130 | -3 | 0.763 |
VRK2 |
0.766 | -0.100 | 1 | 0.828 |
PKCE |
0.765 | 0.077 | 2 | 0.626 |
NEK6 |
0.765 | -0.138 | -2 | 0.754 |
CK2A1 |
0.765 | 0.256 | 1 | 0.691 |
CHAK1 |
0.765 | -0.093 | 2 | 0.651 |
DYRK3 |
0.765 | 0.083 | 1 | 0.622 |
MLK2 |
0.765 | -0.144 | 2 | 0.697 |
ROCK2 |
0.764 | 0.126 | -3 | 0.850 |
TLK2 |
0.764 | -0.027 | 1 | 0.834 |
DYRK4 |
0.763 | 0.040 | 1 | 0.505 |
PAK5 |
0.763 | 0.072 | -2 | 0.637 |
MLK3 |
0.762 | -0.089 | 2 | 0.640 |
ACVR2A |
0.762 | 0.002 | -2 | 0.710 |
PKCI |
0.762 | 0.042 | 2 | 0.643 |
DMPK1 |
0.762 | 0.152 | -3 | 0.857 |
ACVR2B |
0.762 | -0.012 | -2 | 0.720 |
TLK1 |
0.761 | -0.024 | -2 | 0.735 |
BMPR1A |
0.761 | 0.056 | 1 | 0.777 |
HIPK1 |
0.761 | 0.044 | 1 | 0.606 |
BRAF |
0.761 | -0.052 | -4 | 0.748 |
PAK4 |
0.760 | 0.067 | -2 | 0.648 |
IRAK4 |
0.760 | -0.033 | 1 | 0.810 |
DYRK1B |
0.760 | 0.038 | 1 | 0.537 |
GSK3B |
0.759 | 0.057 | 4 | 0.558 |
JNK2 |
0.759 | 0.007 | 1 | 0.481 |
GRK2 |
0.757 | -0.032 | -2 | 0.649 |
ROCK1 |
0.757 | 0.124 | -3 | 0.841 |
PERK |
0.757 | -0.086 | -2 | 0.751 |
MLK4 |
0.757 | -0.115 | 2 | 0.639 |
TTBK1 |
0.757 | -0.010 | 2 | 0.673 |
JNK3 |
0.757 | -0.011 | 1 | 0.526 |
PINK1 |
0.756 | -0.110 | 1 | 0.774 |
HRI |
0.755 | -0.116 | -2 | 0.758 |
PLK4 |
0.755 | -0.067 | 2 | 0.673 |
CRIK |
0.755 | 0.132 | -3 | 0.809 |
YSK4 |
0.754 | -0.161 | 1 | 0.718 |
HIPK3 |
0.754 | 0.030 | 1 | 0.597 |
MEK5 |
0.754 | -0.165 | 2 | 0.730 |
PLK2 |
0.754 | 0.056 | -3 | 0.718 |
GSK3A |
0.754 | 0.058 | 4 | 0.569 |
HIPK2 |
0.754 | 0.020 | 1 | 0.499 |
NEK5 |
0.754 | -0.104 | 1 | 0.812 |
PKG1 |
0.753 | 0.106 | -2 | 0.657 |
CDK8 |
0.753 | -0.060 | 1 | 0.545 |
MEKK3 |
0.752 | -0.134 | 1 | 0.747 |
STK33 |
0.752 | -0.030 | 2 | 0.659 |
PRP4 |
0.750 | -0.045 | -3 | 0.680 |
IRAK1 |
0.750 | -0.110 | -1 | 0.786 |
P38A |
0.750 | -0.036 | 1 | 0.560 |
GAK |
0.750 | -0.029 | 1 | 0.746 |
CDK7 |
0.749 | -0.064 | 1 | 0.551 |
ERK2 |
0.749 | -0.040 | 1 | 0.536 |
CAMKK1 |
0.749 | -0.083 | -2 | 0.728 |
NEK8 |
0.749 | -0.108 | 2 | 0.713 |
CAMKK2 |
0.749 | -0.058 | -2 | 0.741 |
CDK2 |
0.749 | -0.064 | 1 | 0.586 |
MST3 |
0.749 | -0.092 | 2 | 0.694 |
PDK1 |
0.748 | -0.030 | 1 | 0.757 |
ZAK |
0.748 | -0.149 | 1 | 0.736 |
CDK13 |
0.748 | -0.063 | 1 | 0.519 |
EEF2K |
0.747 | -0.036 | 3 | 0.678 |
GRK3 |
0.747 | -0.009 | -2 | 0.600 |
CDK19 |
0.745 | -0.062 | 1 | 0.499 |
MEKK2 |
0.745 | -0.170 | 2 | 0.711 |
CDK1 |
0.745 | -0.062 | 1 | 0.503 |
CDK5 |
0.745 | -0.074 | 1 | 0.572 |
LRRK2 |
0.745 | -0.059 | 2 | 0.735 |
CDK14 |
0.744 | -0.016 | 1 | 0.509 |
TAO2 |
0.744 | -0.098 | 2 | 0.716 |
KIS |
0.744 | -0.068 | 1 | 0.573 |
CDK10 |
0.744 | -0.008 | 1 | 0.498 |
CDK9 |
0.744 | -0.068 | 1 | 0.522 |
LKB1 |
0.743 | -0.099 | -3 | 0.753 |
CK1E |
0.743 | -0.058 | -3 | 0.438 |
TAO3 |
0.743 | -0.124 | 1 | 0.739 |
NEK4 |
0.742 | -0.108 | 1 | 0.767 |
VRK1 |
0.742 | -0.086 | 2 | 0.766 |
CDK12 |
0.742 | -0.055 | 1 | 0.491 |
P38B |
0.742 | -0.035 | 1 | 0.483 |
MEKK1 |
0.742 | -0.237 | 1 | 0.778 |
MOK |
0.741 | 0.068 | 1 | 0.625 |
NEK1 |
0.741 | -0.056 | 1 | 0.779 |
CDK18 |
0.741 | -0.051 | 1 | 0.467 |
P38G |
0.740 | -0.045 | 1 | 0.403 |
LOK |
0.739 | -0.063 | -2 | 0.733 |
TAK1 |
0.739 | -0.098 | 1 | 0.808 |
ERK1 |
0.739 | -0.054 | 1 | 0.471 |
NEK11 |
0.739 | -0.177 | 1 | 0.737 |
MAK |
0.738 | 0.051 | -2 | 0.690 |
TNIK |
0.738 | -0.084 | 3 | 0.669 |
GCK |
0.737 | -0.114 | 1 | 0.741 |
MST2 |
0.737 | -0.123 | 1 | 0.760 |
RIPK2 |
0.737 | -0.102 | 1 | 0.696 |
HGK |
0.737 | -0.102 | 3 | 0.657 |
CK1A2 |
0.737 | -0.053 | -3 | 0.397 |
HPK1 |
0.737 | -0.078 | 1 | 0.723 |
JNK1 |
0.736 | -0.020 | 1 | 0.471 |
MEKK6 |
0.736 | -0.123 | 1 | 0.741 |
CDK3 |
0.736 | -0.045 | 1 | 0.431 |
CK1D |
0.735 | -0.057 | -3 | 0.388 |
MPSK1 |
0.734 | -0.097 | 1 | 0.712 |
P38D |
0.734 | -0.023 | 1 | 0.445 |
MINK |
0.733 | -0.131 | 1 | 0.747 |
SLK |
0.733 | -0.085 | -2 | 0.663 |
CK1G1 |
0.733 | -0.079 | -3 | 0.442 |
CDK17 |
0.732 | -0.068 | 1 | 0.412 |
CDK16 |
0.732 | -0.040 | 1 | 0.432 |
HASPIN |
0.732 | 0.037 | -1 | 0.743 |
MST1 |
0.732 | -0.114 | 1 | 0.747 |
ERK7 |
0.732 | -0.052 | 2 | 0.443 |
MAP3K15 |
0.732 | -0.151 | 1 | 0.709 |
KHS2 |
0.731 | -0.053 | 1 | 0.741 |
YANK3 |
0.731 | 0.007 | 2 | 0.502 |
KHS1 |
0.731 | -0.081 | 1 | 0.732 |
PBK |
0.730 | -0.051 | 1 | 0.659 |
CDK4 |
0.730 | -0.040 | 1 | 0.481 |
MEK2 |
0.728 | -0.170 | 2 | 0.729 |
YSK1 |
0.726 | -0.125 | 2 | 0.662 |
CDK6 |
0.726 | -0.057 | 1 | 0.487 |
TTK |
0.725 | -0.084 | -2 | 0.730 |
ALPHAK3 |
0.724 | -0.026 | -1 | 0.737 |
PDHK3_TYR |
0.723 | 0.169 | 4 | 0.890 |
BIKE |
0.720 | -0.022 | 1 | 0.593 |
NEK3 |
0.720 | -0.148 | 1 | 0.719 |
MYO3B |
0.719 | -0.087 | 2 | 0.683 |
OSR1 |
0.718 | -0.137 | 2 | 0.692 |
PDHK4_TYR |
0.712 | 0.046 | 2 | 0.755 |
TAO1 |
0.712 | -0.115 | 1 | 0.679 |
ASK1 |
0.711 | -0.154 | 1 | 0.695 |
MYO3A |
0.711 | -0.131 | 1 | 0.772 |
TESK1_TYR |
0.711 | -0.041 | 3 | 0.693 |
LIMK2_TYR |
0.709 | 0.009 | -3 | 0.832 |
MAP2K6_TYR |
0.709 | -0.024 | -1 | 0.846 |
MAP2K7_TYR |
0.709 | -0.046 | 2 | 0.760 |
MAP2K4_TYR |
0.707 | -0.059 | -1 | 0.841 |
DDR1 |
0.706 | -0.014 | 4 | 0.808 |
PINK1_TYR |
0.706 | -0.079 | 1 | 0.790 |
PDHK1_TYR |
0.706 | -0.029 | -1 | 0.865 |
EPHA6 |
0.705 | -0.020 | -1 | 0.852 |
BMPR2_TYR |
0.705 | -0.051 | -1 | 0.826 |
STLK3 |
0.704 | -0.137 | 1 | 0.712 |
AAK1 |
0.704 | 0.000 | 1 | 0.473 |
PKMYT1_TYR |
0.702 | -0.140 | 3 | 0.647 |
RET |
0.701 | -0.077 | 1 | 0.761 |
LIMK1_TYR |
0.700 | -0.095 | 2 | 0.743 |
EPHB4 |
0.699 | -0.044 | -1 | 0.848 |
CK1A |
0.699 | -0.068 | -3 | 0.306 |
TYRO3 |
0.698 | -0.088 | 3 | 0.574 |
EPHA4 |
0.697 | 0.006 | 2 | 0.750 |
CK1G3 |
0.695 | -0.055 | -3 | 0.267 |
TNK2 |
0.694 | -0.061 | 3 | 0.525 |
EPHB1 |
0.694 | -0.025 | 1 | 0.814 |
MST1R |
0.693 | -0.126 | 3 | 0.581 |
SRMS |
0.693 | -0.038 | 1 | 0.822 |
YANK2 |
0.693 | -0.037 | 2 | 0.514 |
EPHB3 |
0.692 | -0.029 | -1 | 0.842 |
INSRR |
0.692 | -0.072 | 3 | 0.533 |
TYK2 |
0.691 | -0.155 | 1 | 0.761 |
EPHB2 |
0.691 | -0.025 | -1 | 0.837 |
ROS1 |
0.690 | -0.135 | 3 | 0.543 |
FER |
0.690 | -0.082 | 1 | 0.840 |
AXL |
0.690 | -0.057 | 3 | 0.543 |
ABL2 |
0.689 | -0.098 | -1 | 0.821 |
DDR2 |
0.689 | -0.007 | 3 | 0.513 |
MERTK |
0.689 | -0.035 | 3 | 0.554 |
TNK1 |
0.689 | -0.050 | 3 | 0.560 |
YES1 |
0.688 | -0.094 | -1 | 0.850 |
ITK |
0.688 | -0.088 | -1 | 0.804 |
LTK |
0.688 | -0.043 | 3 | 0.521 |
TXK |
0.688 | -0.055 | 1 | 0.793 |
TEK |
0.687 | -0.085 | 3 | 0.513 |
FGFR2 |
0.687 | -0.109 | 3 | 0.574 |
CSF1R |
0.687 | -0.161 | 3 | 0.562 |
PDGFRB |
0.686 | -0.132 | 3 | 0.575 |
EPHA7 |
0.686 | -0.034 | 2 | 0.758 |
JAK2 |
0.685 | -0.175 | 1 | 0.749 |
EPHA3 |
0.685 | -0.037 | 2 | 0.733 |
ABL1 |
0.685 | -0.103 | -1 | 0.819 |
JAK3 |
0.685 | -0.149 | 1 | 0.741 |
FLT3 |
0.685 | -0.117 | 3 | 0.571 |
TEC |
0.685 | -0.049 | -1 | 0.765 |
EPHA1 |
0.684 | -0.056 | 3 | 0.526 |
PDGFRA |
0.683 | -0.113 | 3 | 0.573 |
PTK2B |
0.683 | -0.008 | -1 | 0.814 |
KDR |
0.683 | -0.120 | 3 | 0.535 |
EPHA5 |
0.683 | -0.015 | 2 | 0.743 |
ALK |
0.682 | -0.084 | 3 | 0.500 |
FGR |
0.682 | -0.167 | 1 | 0.773 |
HCK |
0.682 | -0.111 | -1 | 0.821 |
WEE1_TYR |
0.682 | -0.063 | -1 | 0.744 |
TNNI3K_TYR |
0.682 | -0.082 | 1 | 0.784 |
NEK10_TYR |
0.681 | -0.102 | 1 | 0.628 |
BMX |
0.681 | -0.057 | -1 | 0.726 |
FGFR1 |
0.681 | -0.124 | 3 | 0.544 |
PTK6 |
0.681 | -0.079 | -1 | 0.736 |
KIT |
0.680 | -0.151 | 3 | 0.564 |
FRK |
0.680 | -0.060 | -1 | 0.848 |
BTK |
0.680 | -0.124 | -1 | 0.785 |
FLT4 |
0.678 | -0.115 | 3 | 0.538 |
NTRK1 |
0.678 | -0.125 | -1 | 0.807 |
LCK |
0.677 | -0.116 | -1 | 0.819 |
BLK |
0.677 | -0.099 | -1 | 0.833 |
FGFR3 |
0.677 | -0.117 | 3 | 0.550 |
EPHA8 |
0.674 | -0.065 | -1 | 0.811 |
INSR |
0.673 | -0.121 | 3 | 0.510 |
FLT1 |
0.673 | -0.142 | -1 | 0.799 |
CSK |
0.673 | -0.079 | 2 | 0.766 |
FYN |
0.673 | -0.070 | -1 | 0.782 |
MET |
0.672 | -0.167 | 3 | 0.551 |
ERBB2 |
0.672 | -0.132 | 1 | 0.705 |
MATK |
0.672 | -0.104 | -1 | 0.760 |
NTRK2 |
0.670 | -0.166 | 3 | 0.536 |
JAK1 |
0.669 | -0.159 | 1 | 0.687 |
LYN |
0.668 | -0.119 | 3 | 0.509 |
EGFR |
0.668 | -0.063 | 1 | 0.613 |
PTK2 |
0.668 | -0.031 | -1 | 0.730 |
CK1G2 |
0.667 | -0.090 | -3 | 0.362 |
EPHA2 |
0.664 | -0.073 | -1 | 0.765 |
SYK |
0.663 | -0.043 | -1 | 0.722 |
FGFR4 |
0.662 | -0.098 | -1 | 0.763 |
SRC |
0.662 | -0.115 | -1 | 0.799 |
NTRK3 |
0.662 | -0.149 | -1 | 0.759 |
MUSK |
0.660 | -0.103 | 1 | 0.593 |
IGF1R |
0.659 | -0.109 | 3 | 0.463 |
ERBB4 |
0.654 | -0.082 | 1 | 0.643 |
FES |
0.646 | -0.102 | -1 | 0.709 |
ZAP70 |
0.627 | -0.122 | -1 | 0.653 |