Motif 683 (n=157)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087WV96 | CYP3A7-CYP3A51P | S139 | ochoa | Cytochrome P450 3A (EC 1.14.14.-) | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. {ECO:0000256|RuleBase:RU368049}. |
| A0MZ66 | SHTN1 | S249 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A6NMD2 | GOLGA8J | S260 | ochoa | Golgin subfamily A member 8J | None |
| F8WAN1 | SPECC1L-ADORA2A | S171 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| H3BQL2 | GOLGA8T | S260 | ochoa | Golgin subfamily A member 8T | None |
| H3BSY2 | GOLGA8M | S260 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S260 | ochoa | Golgin subfamily A member 8R | None |
| O00273 | DFFA | S228 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| O00311 | CDC7 | S318 | psp | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O14578 | CIT | S795 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O43166 | SIPA1L1 | S1734 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43290 | SART1 | S348 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O43432 | EIF4G3 | S1413 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43663 | PRC1 | S265 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O43747 | AP1G1 | S369 | ochoa | AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000269|PubMed:34102099}. |
| O75150 | RNF40 | S853 | psp | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75379 | VAMP4 | S88 | ochoa | Vesicle-associated membrane protein 4 (VAMP-4) | Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. |
| O75533 | SF3B1 | S73 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O95183 | VAMP5 | S41 | ochoa | Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin) | May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking. |
| O95613 | PCNT | S644 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95721 | SNAP29 | S78 | ochoa | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
| O95816 | BAG2 | S25 | ochoa | BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2) | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9873016}. |
| P02545 | LMNA | S303 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02686 | MBP | S114 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P05783 | KRT18 | S242 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P08238 | HSP90AB1 | S452 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P08684 | CYP3A4 | S139 | ochoa | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P08684 | CYP3A4 | S398 | psp | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P0CJ92 | GOLGA8H | S260 | ochoa | Golgin subfamily A member 8H | None |
| P11055 | MYH3 | S1479 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11055 | MYH3 | S1777 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | S1482 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1780 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1478 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1776 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1480 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1778 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1481 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13535 | MYH8 | S1779 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P15311 | EZR | S535 | ochoa | Ezrin (Cytovillin) (Villin-2) (p81) | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
| P15735 | PHKG2 | S269 | ochoa | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (PubMed:35549678). {ECO:0000250|UniProtKB:P31325, ECO:0000269|PubMed:10487978, ECO:0000269|PubMed:35549678}. |
| P19429 | TNNI3 | S44 | psp | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P20700 | LMNB1 | S304 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P20815 | CYP3A5 | S139 | ochoa | Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3) | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:2732228}. |
| P24462 | CYP3A7 | S139 | ochoa | Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (Cytochrome P450-HFLA) (P450HLp2) | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PubMed:11093772, PubMed:12865317, PubMed:14559847, PubMed:17178770, PubMed:9555064). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11093772, PubMed:12865317, PubMed:14559847, PubMed:17178770, PubMed:9555064). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones (PubMed:17178770, PubMed:9555064). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position (PubMed:12865317, PubMed:14559847). Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics including anticonvulsants (PubMed:9555064). {ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:17178770, ECO:0000269|PubMed:9555064}. |
| P25440 | BRD2 | S744 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P26641 | EEF1G | S304 | ochoa | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | Probably plays a role in anchoring the complex to other cellular components. |
| P29692 | EEF1D | S44 | ochoa | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
| P35240 | NF2 | S518 | ochoa|psp | Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) | Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}. |
| P35241 | RDX | S532 | ochoa | Radixin | Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. |
| P35579 | MYH9 | S1057 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35580 | MYH10 | S1145 | ochoa | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P35749 | MYH11 | S589 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35749 | MYH11 | S1770 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P37198 | NUP62 | S468 | ochoa | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}. |
| P49019 | HCAR3 | S328 | ochoa | Hydroxycarboxylic acid receptor 3 (G-protein coupled receptor 109B) (G-protein coupled receptor HM74) (G-protein coupled receptor HM74B) (Niacin receptor 2) (Nicotinic acid receptor 2) | Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:19561068}. |
| P51572 | BCAP31 | S216 | ochoa | B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28) | Functions as a chaperone protein (PubMed:18287538, PubMed:9396746). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:18287538, PubMed:9396746). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:18287538, PubMed:9396746). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671). {ECO:0000250|UniProtKB:Q61335, ECO:0000269|PubMed:10958671, ECO:0000269|PubMed:18287538, ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:9396746}. |
| P52630 | STAT2 | S734 | psp | Signal transducer and activator of transcription 2 (p113) | Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}. |
| P52732 | KIF11 | T458 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P62195 | PSMC5 | S120 | psp | 26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| P80303 | NUCB2 | S89 | ochoa | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}. |
| Q01658 | DR1 | S105 | ochoa | Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}. |
| Q02818 | NUCB1 | S86 | ochoa | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q03252 | LMNB2 | S318 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q08117 | TLE5 | S68 | ochoa | TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator) | Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. {ECO:0000269|PubMed:10660609, ECO:0000269|PubMed:10748198}. |
| Q08378 | GOLGA3 | S1213 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q12756 | KIF1A | S1368 | ochoa | Kinesin-like protein KIF1A (EC 5.6.1.3) (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:33880452}. |
| Q13200 | PSMD2 | S46 | ochoa | 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. |
| Q13315 | ATM | S2996 | ochoa|psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q14145 | KEAP1 | S53 | psp | Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15601839, PubMed:15983046, PubMed:37339955). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:19489739, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835). {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16006525, ECO:0000269|PubMed:17046835, ECO:0000269|PubMed:17127771, ECO:0000269|PubMed:18251510, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:37339955}. |
| Q14690 | PDCD11 | S1407 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q14807 | KIF22 | S423 | ochoa | Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}. |
| Q15390 | MTFR1 | S124 | ochoa | Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) | May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}. |
| Q16822 | PCK2 | S34 | ochoa | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2) | Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:28955899). Can play an active role in glyceroneogenesis and gluconeogenesis (PubMed:28955899). {ECO:0000269|PubMed:28955899}. |
| Q5JR59 | MTUS2 | S1302 | ochoa | Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) | Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. {ECO:0000269|PubMed:19543227}. |
| Q674X7 | KAZN | S20 | ochoa | Kazrin | Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}. |
| Q69YQ0 | SPECC1L | S171 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6NZI2 | CAVIN1 | S40 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6P0Q8 | MAST2 | S1429 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6ZNC4 | ZNF704 | S77 | ochoa | Zinc finger protein 704 | Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}. |
| Q6ZUJ8 | PIK3AP1 | S426 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q7Z406 | MYH14 | S1324 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q7Z4H8 | POGLUT3 | S421 | ochoa | Protein O-glucosyltransferase 3 (EC 2.4.1.-) (KDEL motif-containing protein 2) (Protein O-xylosyltransferase POGLUT3) (EC 2.4.2.-) | Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 (PubMed:30127001, PubMed:34411563). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001). {ECO:0000269|PubMed:30127001, ECO:0000269|PubMed:34411563}. |
| Q86UP2 | KTN1 | S1318 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q8IW35 | CEP97 | S545 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IX12 | CCAR1 | S1080 | ochoa | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}. |
| Q8N4C6 | NIN | S1193 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N6H7 | ARFGAP2 | Y278 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8ND76 | CCNY | S288 | psp | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
| Q8NDI1 | EHBP1 | S245 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NEZ4 | KMT2C | S1435 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TBA6 | GOLGA5 | S465 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TBZ3 | WDR20 | S492 | ochoa | WD repeat-containing protein 20 (Protein DMR) | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:30466959}. |
| Q8TDM6 | DLG5 | S296 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDS4 | HCAR2 | S328 | ochoa | Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor) | Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. {ECO:0000269|PubMed:17932499}. |
| Q8TDY2 | RB1CC1 | S237 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8WYP5 | AHCTF1 | S1278 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92608 | DOCK2 | S1592 | ochoa | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q92766 | RREB1 | S1388 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92783 | STAM | S191 | ochoa | Signal transducing adapter molecule 1 (STAM-1) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.; FUNCTION: (Microbial infection) Plays an important role in Dengue virus entry. {ECO:0000269|PubMed:29742433}. |
| Q92805 | GOLGA1 | S160 | ochoa | Golgin subfamily A member 1 (Golgin-97) | Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23 (PubMed:29084197, PubMed:38552021). Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers (PubMed:34969853). {ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:38552021}.; FUNCTION: (Microbial infection) Plays an important role in poxvirus morphogenesis. Translocates into the viral factories where it may transport the membrane fragments and associated protein factors important for virus maturation to the sites of virion assembly. {ECO:0000269|PubMed:17276477}. |
| Q96EV2 | RBM33 | S54 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96H12 | MSANTD3 | S98 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 3 | None |
| Q96JH7 | VCPIP1 | S185 | ochoa | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
| Q96JI7 | SPG11 | S1829 | ochoa | Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) | May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. {ECO:0000269|PubMed:24794856}. |
| Q96KC8 | DNAJC1 | S89 | ochoa | DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) | May modulate protein synthesis. {ECO:0000250}. |
| Q96KC8 | DNAJC1 | S492 | ochoa | DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) | May modulate protein synthesis. {ECO:0000250}. |
| Q96P47 | AGAP3 | S219 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1) | GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359, ECO:0000305}. |
| Q9BS91 | SLC35A5 | S394 | ochoa | UDP-sugar transporter protein SLC35A5 (Solute carrier family 35 member A5) | Probable UDP-sugar:UMP transmembrane antiporter involved in UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport from the cytosol to the lumen of the Golgi. {ECO:0000269|PubMed:2322548, ECO:0000269|PubMed:30641943}. |
| Q9BSJ6 | PIMREG | S26 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BSW2 | CRACR2A | S263 | ochoa | EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46) (EC 3.6.5.2) | [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269|PubMed:20418871, ECO:0000269|PubMed:27016526}.; FUNCTION: [Isoform 2]: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (PubMed:31092558). During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function (PubMed:31092558). Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (PubMed:30814157). Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526). In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (PubMed:27016526). Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160). Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (PubMed:27016526). {ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:29987160, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. |
| Q9BU64 | CENPO | S35 | ochoa | Centromere protein O (CENP-O) (Interphase centromere complex protein 36) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:16932742, ECO:0000269|PubMed:18007590}. |
| Q9BV73 | CEP250 | S264 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BV73 | CEP250 | S1991 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BYB0 | SHANK3 | S686 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9C073 | FAM117A | S145 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9H081 | MIS12 | S185 | ochoa | Protein MIS12 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108). {ECO:0000269|PubMed:12515822, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270, ECO:0000269|PubMed:23891108}. |
| Q9H6A9 | PCNX3 | S246 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9HB14 | KCNK13 | S343 | ochoa | Potassium channel subfamily K member 13 (Tandem pore domain halothane-inhibited potassium channel 1) (THIK-1) | K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:24163367, PubMed:25148687, PubMed:30472253, PubMed:38409076). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:25148687). Contributes most of K(+) currents at the plasma membrane of resting microglia. Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (PubMed:38409076). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (By similarity) (PubMed:38409076). {ECO:0000250|UniProtKB:Q8R1P5, ECO:0000269|PubMed:24163367, ECO:0000269|PubMed:25148687, ECO:0000269|PubMed:30472253, ECO:0000269|PubMed:38409076}. |
| Q9NQX4 | MYO5C | S1247 | ochoa | Unconventional myosin-Vc | May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues. |
| Q9NTJ3 | SMC4 | S355 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9P0K7 | RAI14 | S482 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9UEY8 | ADD3 | S42 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UKA4 | AKAP11 | S1103 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKX2 | MYH2 | S1782 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S1482 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UKX3 | MYH13 | S1780 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UKY1 | ZHX1 | S590 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9ULC0 | EMCN | S237 | ochoa | Endomucin (Endomucin-2) (Gastric cancer antigen Ga34) (Mucin-14) (MUC-14) | Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. |
| Q9ULD2 | MTUS1 | S958 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULD2 | MTUS1 | S1203 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9UNL2 | SSR3 | S105 | ochoa | Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. |
| Q9Y463 | DYRK1B | S49 | psp | Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase) | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance (PubMed:33469661). During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 (PubMed:32611815). Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). {ECO:0000269|PubMed:10910078, ECO:0000269|PubMed:11980910, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:24827035, ECO:0000269|PubMed:33469661}. |
| Q9Y490 | TLN1 | S1225 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y5X3 | SNX5 | S22 | ochoa | Sorting nexin-5 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496, ECO:0000303|PubMed:23085988}. |
| Q9Y623 | MYH4 | S1482 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y623 | MYH4 | S1780 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9BUB5 | MKNK1 | S352 | SIGNOR | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| P33176 | KIF5B | S527 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| Q04864 | REL | S516 | GPS6 | Proto-oncogene c-Rel | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. |
| Q14444 | CAPRIN1 | S200 | Sugiyama | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}. |
| P07900 | HSP90AA1 | S460 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| O43293 | DAPK3 | S371 | Sugiyama | Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) | Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:38009294}. |
| Q8N129 | CNPY4 | S45 | Sugiyama | Protein canopy homolog 4 | Plays a role in the regulation of the cell surface expression of TLR4. {ECO:0000269|PubMed:16338228}. |
| P14866 | HNRNPL | S539 | Sugiyama | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}. |
| Q07157 | TJP1 | S1680 | Sugiyama | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q8NCN5 | PDPR | S127 | Sugiyama | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr) | Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine. {ECO:0000250}. |
| Q9Y3P9 | RABGAP1 | S931 | Sugiyama | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| Q8TCG1 | CIP2A | Y731 | Sugiyama | Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen) | Acts as an inhibitor of protein phosphatase PP2A (PubMed:17632056). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (PubMed:17632056). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). {ECO:0000269|PubMed:17632056, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668}. |
| O60341 | KDM1A | Y494 | Sugiyama | Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) | Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:29358331, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:34655521, ECO:0000269|PubMed:34906447}. |
| Q04637 | EIF4G1 | S1440 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q13627 | DYRK1A | S97 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}. |
| Q9UH65 | SWAP70 | S409 | Sugiyama | Switch-associated protein 70 (SWAP-70) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250, ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}. |
| Q9BQS8 | FYCO1 | S425 | Sugiyama | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
| O95721 | SNAP29 | S210 | Sugiyama | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
| Q8IY84 | NIM1K | S119 | Sugiyama | Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) | None |
| Q9Y5S2 | CDC42BPB | S421 | Sugiyama | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-373755 | Semaphorin interactions | 0.000011 | 4.972 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.000020 | 4.696 |
| R-HSA-199991 | Membrane Trafficking | 0.000069 | 4.163 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.000145 | 3.839 |
| R-HSA-75153 | Apoptotic execution phase | 0.000268 | 3.572 |
| R-HSA-68886 | M Phase | 0.000310 | 3.508 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.000327 | 3.486 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.000413 | 3.384 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.000379 | 3.422 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000413 | 3.384 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.000466 | 3.332 |
| R-HSA-109581 | Apoptosis | 0.000617 | 3.210 |
| R-HSA-5357801 | Programmed Cell Death | 0.000602 | 3.220 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000698 | 3.156 |
| R-HSA-983189 | Kinesins | 0.000756 | 3.121 |
| R-HSA-390522 | Striated Muscle Contraction | 0.000843 | 3.074 |
| R-HSA-68882 | Mitotic Anaphase | 0.000841 | 3.075 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.000866 | 3.062 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.000924 | 3.034 |
| R-HSA-1640170 | Cell Cycle | 0.001517 | 2.819 |
| R-HSA-9675108 | Nervous system development | 0.001552 | 2.809 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.001834 | 2.737 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.001834 | 2.737 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.002329 | 2.633 |
| R-HSA-422475 | Axon guidance | 0.002336 | 2.632 |
| R-HSA-3296197 | Hydroxycarboxylic acid-binding receptors | 0.002468 | 2.608 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.002879 | 2.541 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.003202 | 2.495 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.004246 | 2.372 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.004824 | 2.317 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.004592 | 2.338 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.004936 | 2.307 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.006238 | 2.205 |
| R-HSA-68877 | Mitotic Prometaphase | 0.006787 | 2.168 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.007013 | 2.154 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.008175 | 2.087 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.009079 | 2.042 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.010319 | 1.986 |
| R-HSA-397014 | Muscle contraction | 0.010779 | 1.967 |
| R-HSA-69541 | Stabilization of p53 | 0.012354 | 1.908 |
| R-HSA-68875 | Mitotic Prophase | 0.013115 | 1.882 |
| R-HSA-3371556 | Cellular response to heat stress | 0.013502 | 1.870 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.013830 | 1.859 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.014710 | 1.832 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.014300 | 1.845 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.016775 | 1.775 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.016775 | 1.775 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.017396 | 1.760 |
| R-HSA-1299287 | Tandem pore domain halothane-inhibited K+ channel (THIK) | 0.020407 | 1.690 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.019885 | 1.701 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.017941 | 1.746 |
| R-HSA-437239 | Recycling pathway of L1 | 0.019755 | 1.704 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.019755 | 1.704 |
| R-HSA-69275 | G2/M Transition | 0.020227 | 1.694 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.021090 | 1.676 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.021209 | 1.673 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.021667 | 1.664 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.021667 | 1.664 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.021890 | 1.660 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.023677 | 1.626 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.024632 | 1.608 |
| R-HSA-5688426 | Deubiquitination | 0.024713 | 1.607 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.025888 | 1.587 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.026003 | 1.585 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.027904 | 1.554 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.040401 | 1.394 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.040401 | 1.394 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.040401 | 1.394 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.040401 | 1.394 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.040401 | 1.394 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.040401 | 1.394 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.040401 | 1.394 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.040401 | 1.394 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.040401 | 1.394 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.040401 | 1.394 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.040401 | 1.394 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.037778 | 1.423 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.037778 | 1.423 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.041842 | 1.378 |
| R-HSA-9612973 | Autophagy | 0.035095 | 1.455 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.041218 | 1.385 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.037778 | 1.423 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.036563 | 1.437 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.030896 | 1.510 |
| R-HSA-211981 | Xenobiotics | 0.039109 | 1.408 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.029128 | 1.536 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.043154 | 1.365 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.038870 | 1.410 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.038870 | 1.410 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.032117 | 1.493 |
| R-HSA-162582 | Signal Transduction | 0.039433 | 1.404 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.043644 | 1.360 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.044670 | 1.350 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.079179 | 1.101 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.134444 | 0.871 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.067523 | 1.171 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.094687 | 1.024 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.052141 | 1.283 |
| R-HSA-380287 | Centrosome maturation | 0.055289 | 1.257 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.074152 | 1.130 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.074152 | 1.130 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.079733 | 1.098 |
| R-HSA-9646399 | Aggrephagy | 0.085317 | 1.069 |
| R-HSA-9664873 | Pexophagy | 0.125468 | 0.901 |
| R-HSA-191650 | Regulation of gap junction activity | 0.059989 | 1.222 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.107237 | 0.970 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.073304 | 1.135 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.050601 | 1.296 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.079179 | 1.101 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.125468 | 0.901 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.131245 | 0.882 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.108036 | 0.966 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.050601 | 1.296 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.059989 | 1.222 |
| R-HSA-192905 | vRNP Assembly | 0.134444 | 0.871 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.056455 | 1.248 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.107611 | 0.968 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.128006 | 0.893 |
| R-HSA-3371511 | HSF1 activation | 0.073304 | 1.135 |
| R-HSA-9663891 | Selective autophagy | 0.079733 | 1.098 |
| R-HSA-1632852 | Macroautophagy | 0.081870 | 1.087 |
| R-HSA-9729555 | Sensory perception of sour taste | 0.059989 | 1.222 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.059157 | 1.228 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.070394 | 1.152 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.070394 | 1.152 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.091531 | 1.038 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.091531 | 1.038 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.047590 | 1.322 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.110912 | 0.955 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.127798 | 0.893 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.131245 | 0.882 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.070532 | 1.152 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.127798 | 0.893 |
| R-HSA-1500620 | Meiosis | 0.072332 | 1.141 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.091531 | 1.038 |
| R-HSA-4641258 | Degradation of DVL | 0.076253 | 1.118 |
| R-HSA-182971 | EGFR downregulation | 0.056455 | 1.248 |
| R-HSA-389542 | NADPH regeneration | 0.088628 | 1.052 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.051187 | 1.291 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.073304 | 1.135 |
| R-HSA-4641257 | Degradation of AXIN | 0.076253 | 1.118 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.076253 | 1.118 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.124373 | 0.905 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.127798 | 0.893 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.131245 | 0.882 |
| R-HSA-69481 | G2/M Checkpoints | 0.060361 | 1.219 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.130302 | 0.885 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.107611 | 0.968 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.107611 | 0.968 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.112362 | 0.949 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.069633 | 1.157 |
| R-HSA-164944 | Nef and signal transduction | 0.088628 | 1.052 |
| R-HSA-448706 | Interleukin-1 processing | 0.116399 | 0.934 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.064692 | 1.189 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.067523 | 1.171 |
| R-HSA-169911 | Regulation of Apoptosis | 0.070394 | 1.152 |
| R-HSA-3371568 | Attenuation phase | 0.085317 | 1.069 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.091531 | 1.038 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.091531 | 1.038 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.120971 | 0.917 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.127798 | 0.893 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.130302 | 0.885 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.104206 | 0.982 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.088407 | 1.054 |
| R-HSA-622312 | Inflammasomes | 0.048623 | 1.313 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.060176 | 1.221 |
| R-HSA-9907900 | Proteasome assembly | 0.101091 | 0.995 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 0.125468 | 0.901 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.085317 | 1.069 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 0.088407 | 1.054 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.088407 | 1.054 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.088407 | 1.054 |
| R-HSA-1221632 | Meiotic synapsis | 0.131245 | 0.882 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.131245 | 0.882 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.109959 | 0.959 |
| R-HSA-9659379 | Sensory processing of sound | 0.061848 | 1.209 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.101674 | 0.993 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.082260 | 1.085 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.082260 | 1.085 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.097874 | 1.009 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.101091 | 0.995 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.104337 | 0.982 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.125725 | 0.901 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.123615 | 0.908 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.098569 | 1.006 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.068753 | 1.163 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.070394 | 1.152 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.099588 | 1.002 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.116753 | 0.933 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.125725 | 0.901 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.116399 | 0.934 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.104337 | 0.982 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.055289 | 1.257 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.049731 | 1.303 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.050601 | 1.296 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.134444 | 0.871 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.085317 | 1.069 |
| R-HSA-2262752 | Cellular responses to stress | 0.118369 | 0.927 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.084794 | 1.072 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.114950 | 0.939 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.134395 | 0.872 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.107237 | 0.970 |
| R-HSA-9766229 | Degradation of CDH1 | 0.117593 | 0.930 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.050635 | 1.296 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.104337 | 0.982 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.104337 | 0.982 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.047590 | 1.322 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.046108 | 1.336 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.124373 | 0.905 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.090793 | 1.042 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.131245 | 0.882 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.095469 | 1.020 |
| R-HSA-162906 | HIV Infection | 0.113535 | 0.945 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.110191 | 0.958 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.124373 | 0.905 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.082260 | 1.085 |
| R-HSA-9824272 | Somitogenesis | 0.104337 | 0.982 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.076177 | 1.118 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.052033 | 1.284 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.078998 | 1.102 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.082260 | 1.085 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.127798 | 0.893 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.134713 | 0.871 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.136220 | 0.866 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.143329 | 0.844 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.152123 | 0.818 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.152123 | 0.818 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.160828 | 0.794 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.169443 | 0.771 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.177971 | 0.750 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.186412 | 0.730 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.203035 | 0.692 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.203035 | 0.692 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.203035 | 0.692 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.219322 | 0.659 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.227340 | 0.643 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.227340 | 0.643 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.227340 | 0.643 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.227340 | 0.643 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.227340 | 0.643 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.235277 | 0.628 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.235277 | 0.628 |
| R-HSA-429947 | Deadenylation of mRNA | 0.266221 | 0.575 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.273761 | 0.563 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.174055 | 0.759 |
| R-HSA-72172 | mRNA Splicing | 0.201519 | 0.696 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.185089 | 0.733 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.178752 | 0.748 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.250908 | 0.600 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.197252 | 0.705 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.152123 | 0.818 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.273761 | 0.563 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.273761 | 0.563 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.249008 | 0.604 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.152123 | 0.818 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.160828 | 0.794 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.177971 | 0.750 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 0.186412 | 0.730 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.266221 | 0.575 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.231724 | 0.635 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.163135 | 0.787 |
| R-HSA-6798695 | Neutrophil degranulation | 0.224943 | 0.648 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.143329 | 0.844 |
| R-HSA-9754706 | Atorvastatin ADME | 0.186412 | 0.730 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.266221 | 0.575 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.163872 | 0.785 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.211220 | 0.675 |
| R-HSA-4839726 | Chromatin organization | 0.146547 | 0.834 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.177721 | 0.750 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.203035 | 0.692 |
| R-HSA-200425 | Carnitine shuttle | 0.258604 | 0.587 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.203688 | 0.691 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.211220 | 0.675 |
| R-HSA-5689603 | UCH proteinases | 0.214947 | 0.668 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.249008 | 0.604 |
| R-HSA-5617833 | Cilium Assembly | 0.170703 | 0.768 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.138202 | 0.859 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.196221 | 0.707 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.196221 | 0.707 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.256334 | 0.591 |
| R-HSA-4641265 | Repression of WNT target genes | 0.152123 | 0.818 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 0.194766 | 0.710 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.141710 | 0.849 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.186412 | 0.730 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 0.211220 | 0.675 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.250908 | 0.600 |
| R-HSA-69306 | DNA Replication | 0.259092 | 0.587 |
| R-HSA-177929 | Signaling by EGFR | 0.141710 | 0.849 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.252809 | 0.597 |
| R-HSA-3214842 | HDMs demethylate histones | 0.273761 | 0.563 |
| R-HSA-69206 | G1/S Transition | 0.176437 | 0.753 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.191061 | 0.719 |
| R-HSA-1474165 | Reproduction | 0.191854 | 0.717 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.170401 | 0.769 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.159523 | 0.797 |
| R-HSA-70326 | Glucose metabolism | 0.154025 | 0.812 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.177978 | 0.750 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.222878 | 0.652 |
| R-HSA-373760 | L1CAM interactions | 0.151593 | 0.819 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.177971 | 0.750 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.266221 | 0.575 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.268021 | 0.572 |
| R-HSA-8978934 | Metabolism of cofactors | 0.196221 | 0.707 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.211220 | 0.675 |
| R-HSA-9018682 | Biosynthesis of maresins | 0.258604 | 0.587 |
| R-HSA-9909396 | Circadian clock | 0.197068 | 0.705 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.163135 | 0.787 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.273761 | 0.563 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.245210 | 0.610 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.273761 | 0.563 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.145238 | 0.838 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.186412 | 0.730 |
| R-HSA-351202 | Metabolism of polyamines | 0.155927 | 0.807 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.256334 | 0.591 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.196221 | 0.707 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.264217 | 0.578 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.258604 | 0.587 |
| R-HSA-6807070 | PTEN Regulation | 0.218252 | 0.661 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.199951 | 0.699 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.174055 | 0.759 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.192501 | 0.716 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.207434 | 0.683 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.210250 | 0.677 |
| R-HSA-5619084 | ABC transporter disorders | 0.222485 | 0.653 |
| R-HSA-4086400 | PCP/CE pathway | 0.222485 | 0.653 |
| R-HSA-202424 | Downstream TCR signaling | 0.271825 | 0.566 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.159523 | 0.797 |
| R-HSA-2028269 | Signaling by Hippo | 0.203035 | 0.692 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.261854 | 0.582 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.174055 | 0.759 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.249008 | 0.604 |
| R-HSA-6806834 | Signaling by MET | 0.230044 | 0.638 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.214947 | 0.668 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.260413 | 0.584 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.274476 | 0.561 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.281223 | 0.551 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.281223 | 0.551 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.281223 | 0.551 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.283231 | 0.548 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.287030 | 0.542 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.288610 | 0.540 |
| R-HSA-264876 | Insulin processing | 0.288610 | 0.540 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.288610 | 0.540 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.295921 | 0.529 |
| R-HSA-9757110 | Prednisone ADME | 0.295921 | 0.529 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.298048 | 0.526 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.298414 | 0.525 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.303157 | 0.518 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.303157 | 0.518 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.303157 | 0.518 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.303157 | 0.518 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.303157 | 0.518 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.303157 | 0.518 |
| R-HSA-1280218 | Adaptive Immune System | 0.307367 | 0.512 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.309770 | 0.509 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.310319 | 0.508 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.310319 | 0.508 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.310319 | 0.508 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.310319 | 0.508 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.310319 | 0.508 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.310319 | 0.508 |
| R-HSA-70171 | Glycolysis | 0.317320 | 0.499 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.317320 | 0.499 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.317320 | 0.499 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.317408 | 0.498 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.317408 | 0.498 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.317408 | 0.498 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.317673 | 0.498 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.317673 | 0.498 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.317824 | 0.498 |
| R-HSA-72766 | Translation | 0.320056 | 0.495 |
| R-HSA-1538133 | G0 and Early G1 | 0.324425 | 0.489 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.331370 | 0.480 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.331370 | 0.480 |
| R-HSA-354192 | Integrin signaling | 0.331370 | 0.480 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.331370 | 0.480 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.331370 | 0.480 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.331370 | 0.480 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.331370 | 0.480 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.331370 | 0.480 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.331370 | 0.480 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.332458 | 0.478 |
| R-HSA-9833110 | RSV-host interactions | 0.336110 | 0.474 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.338244 | 0.471 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.338244 | 0.471 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.338244 | 0.471 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.338244 | 0.471 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.338244 | 0.471 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.345048 | 0.462 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.345048 | 0.462 |
| R-HSA-203615 | eNOS activation | 0.345048 | 0.462 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.345048 | 0.462 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.345048 | 0.462 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.345048 | 0.462 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.345048 | 0.462 |
| R-HSA-69239 | Synthesis of DNA | 0.347312 | 0.459 |
| R-HSA-211000 | Gene Silencing by RNA | 0.347312 | 0.459 |
| R-HSA-449147 | Signaling by Interleukins | 0.349614 | 0.456 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.351033 | 0.455 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.351782 | 0.454 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.351782 | 0.454 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.358448 | 0.446 |
| R-HSA-8853659 | RET signaling | 0.358448 | 0.446 |
| R-HSA-202403 | TCR signaling | 0.358453 | 0.446 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.365045 | 0.438 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.365045 | 0.438 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.365045 | 0.438 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.369034 | 0.433 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.371575 | 0.430 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.371575 | 0.430 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.371575 | 0.430 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.371575 | 0.430 |
| R-HSA-9658195 | Leishmania infection | 0.376020 | 0.425 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.376020 | 0.425 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.376864 | 0.424 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.378038 | 0.422 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.378038 | 0.422 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.378038 | 0.422 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.378038 | 0.422 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.382056 | 0.418 |
| R-HSA-9679506 | SARS-CoV Infections | 0.383502 | 0.416 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.384435 | 0.415 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.384435 | 0.415 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.384435 | 0.415 |
| R-HSA-5260271 | Diseases of Immune System | 0.384435 | 0.415 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.384435 | 0.415 |
| R-HSA-8982491 | Glycogen metabolism | 0.384435 | 0.415 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.390766 | 0.408 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.390766 | 0.408 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.390766 | 0.408 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.390766 | 0.408 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.397033 | 0.401 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.397033 | 0.401 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.398667 | 0.399 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.401444 | 0.396 |
| R-HSA-165159 | MTOR signalling | 0.403236 | 0.394 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.408514 | 0.389 |
| R-HSA-8854214 | TBC/RABGAPs | 0.409376 | 0.388 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.409376 | 0.388 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.415452 | 0.381 |
| R-HSA-373752 | Netrin-1 signaling | 0.415452 | 0.381 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.416565 | 0.380 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.421467 | 0.375 |
| R-HSA-774815 | Nucleosome assembly | 0.421467 | 0.375 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.421467 | 0.375 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.421467 | 0.375 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.421467 | 0.375 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.421467 | 0.375 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.427419 | 0.369 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.427419 | 0.369 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.427419 | 0.369 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.427419 | 0.369 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.427419 | 0.369 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.427419 | 0.369 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.427419 | 0.369 |
| R-HSA-9675135 | Diseases of DNA repair | 0.427419 | 0.369 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.427419 | 0.369 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.433312 | 0.363 |
| R-HSA-168256 | Immune System | 0.433711 | 0.363 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.439143 | 0.357 |
| R-HSA-70263 | Gluconeogenesis | 0.439143 | 0.357 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.444915 | 0.352 |
| R-HSA-418990 | Adherens junctions interactions | 0.445066 | 0.352 |
| R-HSA-5576891 | Cardiac conduction | 0.448092 | 0.349 |
| R-HSA-8951664 | Neddylation | 0.453113 | 0.344 |
| R-HSA-912446 | Meiotic recombination | 0.456283 | 0.341 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.461880 | 0.335 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.467419 | 0.330 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.468577 | 0.329 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.472323 | 0.326 |
| R-HSA-72649 | Translation initiation complex formation | 0.472902 | 0.325 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.475305 | 0.323 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.475305 | 0.323 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.478329 | 0.320 |
| R-HSA-9664407 | Parasite infection | 0.481982 | 0.317 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.481982 | 0.317 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.481982 | 0.317 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.483700 | 0.315 |
| R-HSA-5578775 | Ion homeostasis | 0.483700 | 0.315 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.483700 | 0.315 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.494278 | 0.306 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.494278 | 0.306 |
| R-HSA-8939211 | ESR-mediated signaling | 0.495176 | 0.305 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.498445 | 0.302 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.499486 | 0.301 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.499486 | 0.301 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.499486 | 0.301 |
| R-HSA-191859 | snRNP Assembly | 0.499486 | 0.301 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.504641 | 0.297 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.504641 | 0.297 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.504641 | 0.297 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.504641 | 0.297 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.509742 | 0.293 |
| R-HSA-69242 | S Phase | 0.511374 | 0.291 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.514175 | 0.289 |
| R-HSA-9758941 | Gastrulation | 0.514573 | 0.289 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.514792 | 0.288 |
| R-HSA-9707616 | Heme signaling | 0.514792 | 0.288 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.519790 | 0.284 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.519790 | 0.284 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.520645 | 0.283 |
| R-HSA-9824446 | Viral Infection Pathways | 0.522915 | 0.282 |
| R-HSA-8953854 | Metabolism of RNA | 0.523995 | 0.281 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.530357 | 0.275 |
| R-HSA-421270 | Cell-cell junction organization | 0.530638 | 0.275 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.533472 | 0.273 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.539275 | 0.268 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.539275 | 0.268 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.544022 | 0.264 |
| R-HSA-5218859 | Regulated Necrosis | 0.544022 | 0.264 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.553371 | 0.257 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.553371 | 0.257 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.553371 | 0.257 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.557974 | 0.253 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.559911 | 0.252 |
| R-HSA-1266738 | Developmental Biology | 0.562511 | 0.250 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.562530 | 0.250 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.567039 | 0.246 |
| R-HSA-9749641 | Aspirin ADME | 0.567039 | 0.246 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.567039 | 0.246 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.571501 | 0.243 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.575919 | 0.240 |
| R-HSA-8852135 | Protein ubiquitination | 0.575919 | 0.240 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.575919 | 0.240 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.579293 | 0.237 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.584617 | 0.233 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.588900 | 0.230 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.588900 | 0.230 |
| R-HSA-109582 | Hemostasis | 0.592341 | 0.227 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.593139 | 0.227 |
| R-HSA-446728 | Cell junction organization | 0.594930 | 0.226 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.597334 | 0.224 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.597334 | 0.224 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.600796 | 0.221 |
| R-HSA-913531 | Interferon Signaling | 0.600796 | 0.221 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.601486 | 0.221 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.601486 | 0.221 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.601486 | 0.221 |
| R-HSA-5663205 | Infectious disease | 0.601884 | 0.220 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.603961 | 0.219 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.605596 | 0.218 |
| R-HSA-168255 | Influenza Infection | 0.606714 | 0.217 |
| R-HSA-2559583 | Cellular Senescence | 0.609457 | 0.215 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.609664 | 0.215 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.614316 | 0.212 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.617597 | 0.209 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.619445 | 0.208 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.625521 | 0.204 |
| R-HSA-70268 | Pyruvate metabolism | 0.629385 | 0.201 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.634518 | 0.198 |
| R-HSA-195721 | Signaling by WNT | 0.638749 | 0.195 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.641239 | 0.193 |
| R-HSA-168249 | Innate Immune System | 0.641718 | 0.193 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.648115 | 0.188 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.655341 | 0.184 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.658899 | 0.181 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.668564 | 0.175 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.669353 | 0.174 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.669353 | 0.174 |
| R-HSA-1296071 | Potassium Channels | 0.669353 | 0.174 |
| R-HSA-1500931 | Cell-Cell communication | 0.675285 | 0.171 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.676146 | 0.170 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.676146 | 0.170 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.676146 | 0.170 |
| R-HSA-190236 | Signaling by FGFR | 0.676146 | 0.170 |
| R-HSA-6805567 | Keratinization | 0.678078 | 0.169 |
| R-HSA-3214847 | HATs acetylate histones | 0.679490 | 0.168 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.686075 | 0.164 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.689317 | 0.162 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.695702 | 0.158 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.698845 | 0.156 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.698845 | 0.156 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.701956 | 0.154 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.708082 | 0.150 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.711098 | 0.148 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.711098 | 0.148 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.711098 | 0.148 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.714083 | 0.146 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.717038 | 0.144 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.717038 | 0.144 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.722856 | 0.141 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.722856 | 0.141 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.722856 | 0.141 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.725720 | 0.139 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.725826 | 0.139 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.728555 | 0.138 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.728555 | 0.138 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.731733 | 0.136 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.734138 | 0.134 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.736886 | 0.133 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.736886 | 0.133 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.739607 | 0.131 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.739607 | 0.131 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.742299 | 0.129 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.742299 | 0.129 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.742299 | 0.129 |
| R-HSA-5693538 | Homology Directed Repair | 0.744963 | 0.128 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.744963 | 0.128 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.747601 | 0.126 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.747601 | 0.126 |
| R-HSA-157118 | Signaling by NOTCH | 0.750241 | 0.125 |
| R-HSA-73886 | Chromosome Maintenance | 0.752794 | 0.123 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.755350 | 0.122 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.755350 | 0.122 |
| R-HSA-74160 | Gene expression (Transcription) | 0.756787 | 0.121 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.757728 | 0.120 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.757881 | 0.120 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.757881 | 0.120 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.765317 | 0.116 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.765317 | 0.116 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.765317 | 0.116 |
| R-HSA-194138 | Signaling by VEGF | 0.765317 | 0.116 |
| R-HSA-114608 | Platelet degranulation | 0.770148 | 0.113 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.777209 | 0.109 |
| R-HSA-9843745 | Adipogenesis | 0.781797 | 0.107 |
| R-HSA-9717189 | Sensory perception of taste | 0.781797 | 0.107 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.786290 | 0.104 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.809410 | 0.092 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.811384 | 0.091 |
| R-HSA-211859 | Biological oxidations | 0.815042 | 0.089 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.819080 | 0.087 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.820954 | 0.086 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.824646 | 0.084 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.824646 | 0.084 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.830042 | 0.081 |
| R-HSA-1989781 | PPARA activates gene expression | 0.833547 | 0.079 |
| R-HSA-212436 | Generic Transcription Pathway | 0.834194 | 0.079 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.836981 | 0.077 |
| R-HSA-9610379 | HCMV Late Events | 0.836981 | 0.077 |
| R-HSA-162587 | HIV Life Cycle | 0.836981 | 0.077 |
| R-HSA-1643685 | Disease | 0.841555 | 0.075 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.841999 | 0.075 |
| R-HSA-5619102 | SLC transporter disorders | 0.853120 | 0.069 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.859121 | 0.066 |
| R-HSA-72306 | tRNA processing | 0.859121 | 0.066 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.863462 | 0.064 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.863462 | 0.064 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.880016 | 0.056 |
| R-HSA-112316 | Neuronal System | 0.882572 | 0.054 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.883250 | 0.054 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.886851 | 0.052 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.888501 | 0.051 |
| R-HSA-9609690 | HCMV Early Events | 0.892610 | 0.049 |
| R-HSA-597592 | Post-translational protein modification | 0.893366 | 0.049 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.895318 | 0.048 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.899136 | 0.046 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.908008 | 0.042 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.908570 | 0.042 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.911030 | 0.040 |
| R-HSA-9748784 | Drug ADME | 0.915565 | 0.038 |
| R-HSA-72312 | rRNA processing | 0.927075 | 0.033 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.929306 | 0.032 |
| R-HSA-418594 | G alpha (i) signalling events | 0.936780 | 0.028 |
| R-HSA-9609646 | HCMV Infection | 0.939610 | 0.027 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.953054 | 0.021 |
| R-HSA-392499 | Metabolism of proteins | 0.954311 | 0.020 |
| R-HSA-8957322 | Metabolism of steroids | 0.972252 | 0.012 |
| R-HSA-73894 | DNA Repair | 0.981018 | 0.008 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.987297 | 0.006 |
| R-HSA-500792 | GPCR ligand binding | 0.987609 | 0.005 |
| R-HSA-8978868 | Fatty acid metabolism | 0.988573 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.990252 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.990531 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 0.993203 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 0.997846 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.999040 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999222 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999987 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
RSK2 |
0.789 | 0.257 | -3 | 0.933 |
COT |
0.788 | 0.123 | 2 | 0.769 |
PIM3 |
0.787 | 0.201 | -3 | 0.912 |
P90RSK |
0.784 | 0.258 | -3 | 0.929 |
SKMLCK |
0.784 | 0.306 | -2 | 0.793 |
PIM1 |
0.784 | 0.251 | -3 | 0.921 |
PRKD2 |
0.784 | 0.224 | -3 | 0.927 |
RSK3 |
0.784 | 0.246 | -3 | 0.930 |
NDR2 |
0.783 | 0.139 | -3 | 0.884 |
RIPK3 |
0.783 | 0.278 | 3 | 0.491 |
FAM20C |
0.783 | 0.290 | 2 | 0.845 |
SRPK1 |
0.782 | 0.203 | -3 | 0.925 |
NDR1 |
0.782 | 0.188 | -3 | 0.900 |
CDKL1 |
0.781 | 0.249 | -3 | 0.914 |
SRPK2 |
0.781 | 0.222 | -3 | 0.902 |
PKN3 |
0.781 | 0.186 | -3 | 0.896 |
CLK3 |
0.779 | 0.117 | 1 | 0.796 |
RSK4 |
0.779 | 0.242 | -3 | 0.920 |
CDKL5 |
0.778 | 0.213 | -3 | 0.918 |
CAMK1B |
0.778 | 0.211 | -3 | 0.899 |
PRKD1 |
0.777 | 0.164 | -3 | 0.902 |
P70S6KB |
0.776 | 0.221 | -3 | 0.917 |
PRKD3 |
0.776 | 0.245 | -3 | 0.919 |
MYLK4 |
0.776 | 0.231 | -2 | 0.727 |
CDC7 |
0.775 | 0.052 | 1 | 0.907 |
MAPKAPK2 |
0.775 | 0.202 | -3 | 0.917 |
NUAK2 |
0.774 | 0.161 | -3 | 0.908 |
CAMLCK |
0.774 | 0.222 | -2 | 0.790 |
LATS2 |
0.773 | 0.121 | -5 | 0.723 |
NUAK1 |
0.773 | 0.177 | -3 | 0.915 |
MSK2 |
0.773 | 0.217 | -3 | 0.903 |
MSK1 |
0.773 | 0.222 | -3 | 0.906 |
MOS |
0.773 | 0.074 | 1 | 0.905 |
PKACG |
0.772 | 0.167 | -2 | 0.743 |
TGFBR2 |
0.772 | 0.092 | -2 | 0.824 |
MAPKAPK3 |
0.772 | 0.187 | -3 | 0.906 |
SRPK3 |
0.771 | 0.186 | -3 | 0.899 |
PKACB |
0.771 | 0.192 | -2 | 0.676 |
DAPK2 |
0.771 | 0.246 | -3 | 0.878 |
AURC |
0.771 | 0.111 | -2 | 0.651 |
PKCD |
0.769 | 0.126 | 2 | 0.706 |
PRKX |
0.769 | 0.215 | -3 | 0.877 |
PIM2 |
0.769 | 0.247 | -3 | 0.917 |
CAMK2B |
0.769 | 0.177 | 2 | 0.769 |
DSTYK |
0.768 | 0.048 | 2 | 0.806 |
PKN2 |
0.768 | 0.133 | -3 | 0.875 |
WNK1 |
0.767 | 0.096 | -2 | 0.786 |
MELK |
0.767 | 0.187 | -3 | 0.901 |
AKT2 |
0.766 | 0.241 | -3 | 0.906 |
RAF1 |
0.766 | 0.049 | 1 | 0.825 |
PKG2 |
0.766 | 0.170 | -2 | 0.690 |
AURB |
0.766 | 0.122 | -2 | 0.641 |
PRPK |
0.766 | -0.042 | -1 | 0.725 |
AMPKA1 |
0.766 | 0.119 | -3 | 0.891 |
TSSK2 |
0.766 | 0.109 | -5 | 0.760 |
LATS1 |
0.765 | 0.184 | -3 | 0.876 |
CAMK2D |
0.765 | 0.147 | -3 | 0.870 |
TSSK1 |
0.765 | 0.115 | -3 | 0.898 |
CAMK4 |
0.765 | 0.148 | -3 | 0.881 |
NLK |
0.765 | 0.054 | 1 | 0.770 |
ICK |
0.765 | 0.166 | -3 | 0.913 |
ATM |
0.765 | 0.148 | 1 | 0.828 |
NIK |
0.764 | 0.138 | -3 | 0.856 |
CLK1 |
0.764 | 0.183 | -3 | 0.920 |
AMPKA2 |
0.764 | 0.134 | -3 | 0.903 |
PKACA |
0.763 | 0.206 | -2 | 0.642 |
GCN2 |
0.763 | -0.091 | 2 | 0.687 |
MST4 |
0.763 | 0.064 | 2 | 0.741 |
NIM1 |
0.763 | 0.091 | 3 | 0.381 |
CAMK1G |
0.763 | 0.203 | -3 | 0.913 |
CLK4 |
0.763 | 0.180 | -3 | 0.919 |
CAMK2G |
0.763 | 0.013 | 2 | 0.750 |
CLK2 |
0.763 | 0.182 | -3 | 0.935 |
MARK4 |
0.763 | 0.049 | 4 | 0.793 |
CAMK2A |
0.763 | 0.145 | 2 | 0.746 |
SIK |
0.762 | 0.167 | -3 | 0.894 |
WNK3 |
0.761 | 0.060 | 1 | 0.795 |
BMPR2 |
0.761 | -0.005 | -2 | 0.843 |
SGK3 |
0.761 | 0.210 | -3 | 0.893 |
PKCB |
0.761 | 0.103 | 2 | 0.666 |
ATR |
0.761 | 0.052 | 1 | 0.862 |
HIPK4 |
0.761 | 0.097 | 1 | 0.740 |
MNK2 |
0.760 | 0.090 | -2 | 0.744 |
TBK1 |
0.760 | -0.035 | 1 | 0.702 |
PHKG1 |
0.760 | 0.120 | -3 | 0.893 |
PAK1 |
0.760 | 0.102 | -2 | 0.705 |
ERK5 |
0.760 | 0.051 | 1 | 0.777 |
BRSK1 |
0.760 | 0.123 | -3 | 0.910 |
CAMK1D |
0.759 | 0.242 | -3 | 0.894 |
SMMLCK |
0.759 | 0.258 | -3 | 0.902 |
DAPK3 |
0.759 | 0.266 | -3 | 0.917 |
PAK3 |
0.758 | 0.097 | -2 | 0.703 |
MNK1 |
0.758 | 0.106 | -2 | 0.766 |
HUNK |
0.758 | -0.056 | 2 | 0.667 |
IKKB |
0.758 | -0.050 | -2 | 0.672 |
BMPR1B |
0.758 | 0.094 | 1 | 0.855 |
IRE2 |
0.758 | 0.052 | 2 | 0.646 |
P70S6K |
0.757 | 0.224 | -3 | 0.892 |
ULK2 |
0.757 | -0.115 | 2 | 0.679 |
MAPKAPK5 |
0.756 | 0.193 | -3 | 0.874 |
AKT1 |
0.756 | 0.209 | -3 | 0.905 |
MLK1 |
0.756 | -0.023 | 2 | 0.728 |
PDHK4 |
0.756 | -0.116 | 1 | 0.831 |
QSK |
0.756 | 0.092 | 4 | 0.776 |
RIPK1 |
0.755 | 0.050 | 1 | 0.806 |
PKCG |
0.754 | 0.078 | 2 | 0.653 |
NEK7 |
0.754 | -0.061 | -3 | 0.680 |
PKCH |
0.754 | 0.092 | 2 | 0.645 |
ANKRD3 |
0.754 | 0.072 | 1 | 0.834 |
DCAMKL1 |
0.754 | 0.183 | -3 | 0.914 |
IKKE |
0.754 | -0.070 | 1 | 0.692 |
SNRK |
0.753 | 0.063 | 2 | 0.576 |
QIK |
0.753 | 0.075 | -3 | 0.845 |
AKT3 |
0.753 | 0.234 | -3 | 0.883 |
NEK6 |
0.752 | -0.086 | -2 | 0.836 |
GRK1 |
0.752 | 0.011 | -2 | 0.756 |
SGK1 |
0.752 | 0.259 | -3 | 0.871 |
TGFBR1 |
0.752 | 0.052 | -2 | 0.796 |
PAK2 |
0.751 | 0.088 | -2 | 0.686 |
IRE1 |
0.751 | -0.014 | 1 | 0.788 |
ALK2 |
0.751 | 0.092 | -2 | 0.807 |
PAK6 |
0.751 | 0.081 | -2 | 0.626 |
GRK6 |
0.751 | -0.026 | 1 | 0.856 |
MTOR |
0.750 | -0.150 | 1 | 0.752 |
AURA |
0.750 | 0.077 | -2 | 0.607 |
PLK1 |
0.750 | 0.024 | -2 | 0.823 |
CAMK1A |
0.750 | 0.233 | -3 | 0.898 |
BRSK2 |
0.750 | 0.062 | -3 | 0.885 |
PKCA |
0.750 | 0.057 | 2 | 0.653 |
DAPK1 |
0.749 | 0.222 | -3 | 0.909 |
ALK4 |
0.749 | 0.037 | -2 | 0.810 |
PHKG2 |
0.749 | 0.119 | -3 | 0.895 |
ACVR2B |
0.749 | 0.085 | -2 | 0.816 |
CHK2 |
0.749 | 0.251 | -3 | 0.885 |
DYRK1A |
0.749 | 0.163 | 1 | 0.666 |
ULK1 |
0.749 | -0.117 | -3 | 0.681 |
MARK2 |
0.749 | 0.065 | 4 | 0.699 |
DCAMKL2 |
0.749 | 0.147 | -3 | 0.917 |
CHK1 |
0.749 | 0.090 | -3 | 0.873 |
SSTK |
0.748 | 0.076 | 4 | 0.779 |
NEK9 |
0.748 | -0.061 | 2 | 0.716 |
ACVR2A |
0.748 | 0.069 | -2 | 0.809 |
MASTL |
0.748 | -0.066 | -2 | 0.743 |
HIPK1 |
0.747 | 0.128 | 1 | 0.654 |
PKCT |
0.747 | 0.112 | 2 | 0.654 |
MARK1 |
0.747 | 0.064 | 4 | 0.758 |
PKCZ |
0.747 | 0.033 | 2 | 0.674 |
PKR |
0.747 | 0.030 | 1 | 0.827 |
MLK3 |
0.747 | -0.016 | 2 | 0.674 |
DRAK1 |
0.746 | 0.045 | 1 | 0.793 |
MARK3 |
0.746 | 0.044 | 4 | 0.730 |
MLK2 |
0.746 | -0.076 | 2 | 0.724 |
CHAK2 |
0.746 | -0.092 | -1 | 0.753 |
SMG1 |
0.745 | 0.090 | 1 | 0.822 |
DYRK2 |
0.745 | 0.077 | 1 | 0.643 |
PKN1 |
0.745 | 0.186 | -3 | 0.897 |
IKKA |
0.744 | -0.079 | -2 | 0.667 |
MRCKB |
0.744 | 0.212 | -3 | 0.902 |
PDHK1 |
0.744 | -0.192 | 1 | 0.800 |
DLK |
0.744 | -0.087 | 1 | 0.816 |
BMPR1A |
0.744 | 0.080 | 1 | 0.838 |
PKG1 |
0.744 | 0.188 | -2 | 0.619 |
GRK5 |
0.743 | -0.138 | -3 | 0.716 |
KIS |
0.743 | -0.025 | 1 | 0.616 |
TTBK2 |
0.743 | -0.080 | 2 | 0.583 |
MLK4 |
0.742 | -0.021 | 2 | 0.663 |
MRCKA |
0.742 | 0.200 | -3 | 0.901 |
BCKDK |
0.742 | -0.100 | -1 | 0.639 |
IRAK4 |
0.741 | 0.038 | 1 | 0.789 |
HIPK2 |
0.741 | 0.080 | 1 | 0.545 |
DYRK3 |
0.740 | 0.149 | 1 | 0.661 |
DNAPK |
0.740 | 0.066 | 1 | 0.729 |
GRK4 |
0.739 | -0.094 | -2 | 0.801 |
PLK4 |
0.739 | -0.004 | 2 | 0.518 |
HIPK3 |
0.739 | 0.104 | 1 | 0.642 |
ROCK2 |
0.739 | 0.207 | -3 | 0.898 |
PASK |
0.739 | 0.108 | -3 | 0.876 |
PLK3 |
0.739 | -0.027 | 2 | 0.684 |
MEK1 |
0.738 | -0.037 | 2 | 0.735 |
CDK7 |
0.738 | -0.014 | 1 | 0.604 |
CDK14 |
0.738 | 0.091 | 1 | 0.575 |
DMPK1 |
0.738 | 0.227 | -3 | 0.918 |
CDK18 |
0.738 | 0.045 | 1 | 0.533 |
PKCE |
0.738 | 0.116 | 2 | 0.635 |
WNK4 |
0.737 | 0.031 | -2 | 0.760 |
CHAK1 |
0.737 | -0.087 | 2 | 0.635 |
SBK |
0.736 | 0.239 | -3 | 0.866 |
NEK2 |
0.736 | -0.060 | 2 | 0.689 |
BRAF |
0.736 | 0.030 | -4 | 0.806 |
DYRK1B |
0.736 | 0.089 | 1 | 0.596 |
PAK4 |
0.736 | 0.083 | -2 | 0.576 |
GRK7 |
0.736 | -0.021 | 1 | 0.785 |
PAK5 |
0.735 | 0.079 | -2 | 0.564 |
HRI |
0.735 | -0.044 | -2 | 0.830 |
PERK |
0.735 | -0.047 | -2 | 0.833 |
PKCI |
0.734 | 0.061 | 2 | 0.648 |
CRIK |
0.734 | 0.242 | -3 | 0.910 |
DYRK4 |
0.733 | 0.079 | 1 | 0.558 |
NEK5 |
0.732 | 0.017 | 1 | 0.825 |
CDK5 |
0.732 | -0.044 | 1 | 0.629 |
VRK2 |
0.732 | -0.138 | 1 | 0.850 |
IRAK1 |
0.732 | -0.010 | -1 | 0.667 |
YSK4 |
0.732 | -0.106 | 1 | 0.746 |
ROCK1 |
0.731 | 0.206 | -3 | 0.899 |
GRK2 |
0.730 | -0.029 | -2 | 0.678 |
CDK17 |
0.730 | 0.014 | 1 | 0.479 |
MEKK3 |
0.730 | -0.038 | 1 | 0.780 |
MEKK1 |
0.729 | -0.041 | 1 | 0.782 |
CDK16 |
0.729 | 0.051 | 1 | 0.501 |
MEK5 |
0.729 | -0.070 | 2 | 0.720 |
MEKK2 |
0.729 | -0.024 | 2 | 0.704 |
CDK8 |
0.728 | -0.068 | 1 | 0.590 |
ERK2 |
0.728 | -0.019 | 1 | 0.600 |
P38A |
0.727 | -0.025 | 1 | 0.637 |
MAK |
0.727 | 0.149 | -2 | 0.636 |
CDK2 |
0.727 | -0.071 | 1 | 0.655 |
TLK1 |
0.727 | -0.066 | -2 | 0.826 |
MST3 |
0.727 | -0.001 | 2 | 0.709 |
MOK |
0.727 | 0.150 | 1 | 0.696 |
TTK |
0.726 | 0.208 | -2 | 0.842 |
CK2A2 |
0.726 | -0.003 | 1 | 0.784 |
CDK10 |
0.726 | 0.024 | 1 | 0.562 |
TLK2 |
0.726 | -0.111 | 1 | 0.803 |
NEK8 |
0.726 | -0.010 | 2 | 0.700 |
JNK2 |
0.726 | -0.015 | 1 | 0.537 |
CDK19 |
0.723 | -0.065 | 1 | 0.550 |
ZAK |
0.723 | -0.091 | 1 | 0.745 |
GAK |
0.723 | 0.024 | 1 | 0.840 |
CDK1 |
0.722 | -0.065 | 1 | 0.568 |
JNK3 |
0.722 | -0.041 | 1 | 0.582 |
CK1E |
0.721 | -0.056 | -3 | 0.404 |
CDK3 |
0.721 | -0.042 | 1 | 0.502 |
ERK1 |
0.721 | -0.031 | 1 | 0.549 |
TAO3 |
0.721 | -0.057 | 1 | 0.764 |
CDK9 |
0.721 | -0.062 | 1 | 0.580 |
TAO2 |
0.720 | -0.032 | 2 | 0.741 |
BUB1 |
0.720 | 0.046 | -5 | 0.693 |
PDK1 |
0.720 | 0.045 | 1 | 0.765 |
P38B |
0.719 | -0.026 | 1 | 0.566 |
CDK13 |
0.719 | -0.075 | 1 | 0.575 |
LOK |
0.718 | 0.012 | -2 | 0.732 |
NEK11 |
0.718 | -0.064 | 1 | 0.757 |
TTBK1 |
0.718 | -0.079 | 2 | 0.508 |
PRP4 |
0.718 | -0.053 | -3 | 0.633 |
NEK4 |
0.717 | -0.021 | 1 | 0.763 |
CK2A1 |
0.716 | -0.010 | 1 | 0.760 |
PINK1 |
0.716 | -0.146 | 1 | 0.784 |
ERK7 |
0.715 | -0.017 | 2 | 0.480 |
MPSK1 |
0.715 | -0.049 | 1 | 0.765 |
RIPK2 |
0.715 | -0.039 | 1 | 0.703 |
CDK12 |
0.715 | -0.062 | 1 | 0.543 |
MEKK6 |
0.715 | -0.023 | 1 | 0.774 |
CAMKK1 |
0.715 | -0.129 | -2 | 0.693 |
GSK3B |
0.714 | -0.029 | 4 | 0.398 |
P38G |
0.713 | -0.042 | 1 | 0.469 |
GRK3 |
0.713 | -0.048 | -2 | 0.644 |
TNIK |
0.713 | -0.033 | 3 | 0.350 |
PLK2 |
0.713 | -0.032 | -3 | 0.658 |
GCK |
0.713 | -0.052 | 1 | 0.770 |
LKB1 |
0.712 | -0.098 | -3 | 0.707 |
CAMKK2 |
0.712 | -0.109 | -2 | 0.689 |
EEF2K |
0.711 | -0.093 | 3 | 0.317 |
NEK1 |
0.711 | -0.021 | 1 | 0.783 |
GSK3A |
0.711 | -0.033 | 4 | 0.407 |
MST2 |
0.710 | -0.072 | 1 | 0.789 |
TNK2 |
0.710 | 0.278 | 3 | 0.496 |
TAK1 |
0.709 | -0.044 | 1 | 0.801 |
HGK |
0.709 | -0.075 | 3 | 0.351 |
CK1D |
0.709 | -0.058 | -3 | 0.352 |
HPK1 |
0.709 | -0.027 | 1 | 0.747 |
MINK |
0.709 | -0.063 | 1 | 0.753 |
SLK |
0.709 | -0.050 | -2 | 0.676 |
LRRK2 |
0.708 | -0.074 | 2 | 0.718 |
CK1A2 |
0.708 | -0.062 | -3 | 0.364 |
EPHA6 |
0.708 | 0.174 | -1 | 0.752 |
MAP3K15 |
0.707 | -0.085 | 1 | 0.728 |
PBK |
0.707 | 0.022 | 1 | 0.769 |
KHS2 |
0.706 | -0.020 | 1 | 0.748 |
CDK4 |
0.706 | -0.031 | 1 | 0.530 |
CK1G1 |
0.706 | -0.095 | -3 | 0.405 |
KHS1 |
0.706 | -0.035 | 1 | 0.738 |
VRK1 |
0.706 | -0.110 | 2 | 0.695 |
BLK |
0.705 | 0.251 | -1 | 0.762 |
HASPIN |
0.705 | 0.020 | -1 | 0.628 |
MEK2 |
0.704 | -0.091 | 2 | 0.699 |
STK33 |
0.704 | -0.099 | 2 | 0.509 |
MST1 |
0.704 | -0.095 | 1 | 0.761 |
PDHK3_TYR |
0.703 | 0.026 | 4 | 0.853 |
CDK6 |
0.702 | -0.057 | 1 | 0.549 |
YSK1 |
0.701 | -0.067 | 2 | 0.695 |
TXK |
0.701 | 0.140 | 1 | 0.872 |
BIKE |
0.701 | 0.037 | 1 | 0.725 |
INSRR |
0.700 | 0.158 | 3 | 0.428 |
YES1 |
0.700 | 0.125 | -1 | 0.755 |
AXL |
0.700 | 0.249 | 3 | 0.492 |
P38D |
0.699 | -0.041 | 1 | 0.496 |
EPHB4 |
0.699 | 0.140 | -1 | 0.737 |
JNK1 |
0.699 | -0.054 | 1 | 0.535 |
NEK3 |
0.699 | -0.062 | 1 | 0.723 |
ALPHAK3 |
0.698 | 0.022 | -1 | 0.644 |
TYRO3 |
0.698 | 0.099 | 3 | 0.397 |
LCK |
0.698 | 0.159 | -1 | 0.753 |
TESK1_TYR |
0.698 | -0.026 | 3 | 0.366 |
MERTK |
0.697 | 0.213 | 3 | 0.458 |
ROS1 |
0.696 | 0.100 | 3 | 0.409 |
ABL2 |
0.696 | 0.106 | -1 | 0.713 |
EPHA1 |
0.696 | 0.227 | 3 | 0.478 |
SRMS |
0.696 | 0.161 | 1 | 0.883 |
TEC |
0.695 | 0.135 | -1 | 0.708 |
HCK |
0.694 | 0.128 | -1 | 0.759 |
MST1R |
0.694 | 0.123 | 3 | 0.447 |
CSF1R |
0.694 | 0.130 | 3 | 0.457 |
PDHK4_TYR |
0.693 | -0.043 | 2 | 0.769 |
PINK1_TYR |
0.693 | -0.013 | 1 | 0.828 |
KDR |
0.693 | 0.168 | 3 | 0.486 |
DDR2 |
0.693 | 0.178 | 3 | 0.460 |
LIMK2_TYR |
0.692 | 0.002 | -3 | 0.816 |
MAP2K6_TYR |
0.692 | -0.047 | -1 | 0.735 |
DDR1 |
0.692 | 0.112 | 4 | 0.783 |
EPHA7 |
0.691 | 0.150 | 2 | 0.681 |
RET |
0.691 | 0.024 | 1 | 0.776 |
MAP2K4_TYR |
0.691 | -0.075 | -1 | 0.735 |
TEK |
0.691 | 0.095 | 3 | 0.410 |
EPHA4 |
0.691 | 0.078 | 2 | 0.680 |
MAP2K7_TYR |
0.691 | -0.121 | 2 | 0.747 |
EPHB3 |
0.690 | 0.104 | -1 | 0.733 |
PKMYT1_TYR |
0.690 | -0.070 | 3 | 0.381 |
EPHB1 |
0.690 | 0.094 | 1 | 0.871 |
FER |
0.690 | 0.039 | 1 | 0.898 |
BMPR2_TYR |
0.689 | -0.035 | -1 | 0.737 |
TAO1 |
0.689 | -0.052 | 1 | 0.686 |
OSR1 |
0.689 | -0.118 | 2 | 0.693 |
MYO3B |
0.689 | -0.063 | 2 | 0.706 |
EPHB2 |
0.689 | 0.095 | -1 | 0.722 |
FGFR2 |
0.688 | 0.119 | 3 | 0.456 |
YANK3 |
0.688 | -0.054 | 2 | 0.324 |
MYO3A |
0.688 | -0.049 | 1 | 0.751 |
ITK |
0.687 | 0.033 | -1 | 0.734 |
JAK3 |
0.687 | 0.065 | 1 | 0.772 |
ABL1 |
0.687 | 0.063 | -1 | 0.706 |
PDHK1_TYR |
0.687 | -0.090 | -1 | 0.752 |
LTK |
0.687 | 0.076 | 3 | 0.403 |
BMX |
0.687 | 0.066 | -1 | 0.690 |
EPHA5 |
0.686 | 0.144 | 2 | 0.685 |
TNK1 |
0.686 | 0.041 | 3 | 0.381 |
FYN |
0.686 | 0.089 | -1 | 0.727 |
TYK2 |
0.686 | -0.011 | 1 | 0.775 |
PDGFRB |
0.685 | 0.060 | 3 | 0.436 |
LIMK1_TYR |
0.685 | -0.088 | 2 | 0.741 |
AAK1 |
0.685 | 0.045 | 1 | 0.618 |
MET |
0.684 | 0.081 | 3 | 0.460 |
FGR |
0.684 | -0.026 | 1 | 0.861 |
ALK |
0.684 | 0.038 | 3 | 0.390 |
LYN |
0.684 | 0.087 | 3 | 0.392 |
FLT3 |
0.683 | 0.026 | 3 | 0.399 |
PTK2B |
0.683 | 0.095 | -1 | 0.704 |
ASK1 |
0.683 | -0.103 | 1 | 0.716 |
JAK2 |
0.683 | 0.001 | 1 | 0.759 |
KIT |
0.682 | 0.047 | 3 | 0.449 |
FGFR1 |
0.682 | 0.058 | 3 | 0.450 |
EPHA3 |
0.682 | 0.063 | 2 | 0.654 |
FGFR3 |
0.681 | 0.109 | 3 | 0.471 |
FRK |
0.681 | 0.075 | -1 | 0.788 |
JAK1 |
0.680 | 0.097 | 1 | 0.710 |
BTK |
0.679 | 0.014 | -1 | 0.734 |
NTRK2 |
0.679 | 0.088 | 3 | 0.469 |
INSR |
0.678 | 0.042 | 3 | 0.415 |
EPHA8 |
0.678 | 0.076 | -1 | 0.712 |
NTRK1 |
0.676 | 0.059 | -1 | 0.677 |
PDGFRA |
0.675 | -0.001 | 3 | 0.428 |
STLK3 |
0.675 | -0.106 | 1 | 0.714 |
FLT4 |
0.674 | 0.035 | 3 | 0.443 |
SRC |
0.673 | 0.031 | -1 | 0.715 |
ERBB2 |
0.671 | -0.010 | 1 | 0.750 |
NEK10_TYR |
0.671 | -0.067 | 1 | 0.639 |
EPHA2 |
0.670 | 0.082 | -1 | 0.681 |
NTRK3 |
0.670 | 0.044 | -1 | 0.634 |
FLT1 |
0.670 | -0.007 | -1 | 0.686 |
PTK2 |
0.669 | 0.053 | -1 | 0.681 |
TNNI3K_TYR |
0.667 | -0.074 | 1 | 0.776 |
IGF1R |
0.667 | 0.004 | 3 | 0.378 |
CK1A |
0.666 | -0.095 | -3 | 0.269 |
WEE1_TYR |
0.665 | -0.075 | -1 | 0.650 |
ERBB4 |
0.665 | 0.051 | 1 | 0.709 |
MATK |
0.664 | -0.029 | -1 | 0.626 |
FGFR4 |
0.661 | 0.030 | -1 | 0.638 |
EGFR |
0.660 | -0.002 | 1 | 0.665 |
PTK6 |
0.660 | -0.139 | -1 | 0.629 |
CSK |
0.657 | -0.066 | 2 | 0.676 |
YANK2 |
0.655 | -0.075 | 2 | 0.358 |
SYK |
0.655 | -0.000 | -1 | 0.662 |
FES |
0.654 | -0.002 | -1 | 0.636 |
CK1G3 |
0.653 | -0.092 | -3 | 0.226 |
MUSK |
0.649 | -0.075 | 1 | 0.669 |
CK1G2 |
0.640 | -0.083 | -3 | 0.321 |
ZAP70 |
0.632 | -0.047 | -1 | 0.592 |