Motif 682 (n=201)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0J9YX86 GOLGA8Q S90 ochoa Golgin A8 family member Q None
A0JNW5 BLTP3B S774 ochoa Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}.
A6NC98 CCDC88B S1253 ochoa Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}.
A6NMD2 GOLGA8J S260 ochoa Golgin subfamily A member 8J None
E9PMD0 None S240 ochoa Uncharacterized protein None
H3BQL2 GOLGA8T S260 ochoa Golgin subfamily A member 8T None
H3BSY2 GOLGA8M S260 ochoa Golgin subfamily A member 8M None
I6L899 GOLGA8R S90 ochoa Golgin subfamily A member 8R None
I6L899 GOLGA8R S260 ochoa Golgin subfamily A member 8R None
O15344 MID1 S213 ochoa E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}.
O43264 ZW10 S103 ochoa Centromere/kinetochore protein zw10 homolog Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000305}.
O43298 ZBTB43 S200 ochoa Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x) May be involved in transcriptional regulation.
O43597 SPRY2 S167 psp Protein sprouty homolog 2 (Spry-2) Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561). {ECO:0000250|UniProtKB:Q9QXV8, ECO:0000269|PubMed:17974561}.
O43747 AP1G1 S369 ochoa AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000269|PubMed:34102099}.
O60216 RAD21 S185 ochoa|psp Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:Q61550, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:25575569, ECO:0000305|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}.
O75116 ROCK2 T979 ochoa Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}.
O75154 RAB11FIP3 S538 ochoa|psp Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148) Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867). {ECO:0000250|UniProtKB:Q8CHD8, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:17628206, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19327867, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26258637, ECO:0000269|PubMed:31204173}.
O75369 FLNB S81 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75469 NR1I2 S200 psp Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}.
O75643 SNRNP200 S756 ochoa U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}.
O75665 OFD1 S899 ochoa|psp Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}.
O75955 FLOT1 Y348 ochoa Flotillin-1 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
O94964 MTCL2 S931 ochoa Microtubule cross-linking factor 2 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)] Microtubule-associated factor that enables integration of the centrosomal and Golgi-associated microtubules on the Golgi membrane, supporting directional migration. Preferentially acts on the perinuclear microtubules accumulated around the Golgi. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain (By similarity). Required for faithful chromosome segregation during mitosis (PubMed:33587225). Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner (By similarity). {ECO:0000250|UniProtKB:E1U8D0, ECO:0000269|PubMed:33587225}.
O95235 KIF20A S683 ochoa|psp Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.
O95613 PCNT S682 ochoa Pericentrin (Kendrin) (Pericentrin-B) Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}.
P02545 LMNA S303 ochoa Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P02545 LMNA S307 ochoa Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P07332 FES S117 ochoa Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}.
P08670 VIM T327 ochoa|psp Vimentin Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}.
P0CJ92 GOLGA8H S260 ochoa Golgin subfamily A member 8H None
P10275 AR S792 psp Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.
P10645 CHGA S438 ochoa Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}.
P10809 HSPD1 S398 ochoa 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}.
P11055 MYH3 S1479 ochoa Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) Muscle contraction.
P11137 MAP2 S1134 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P11532 DMD S3500 ochoa Dystrophin Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}.
P12882 MYH1 T997 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12882 MYH1 T1278 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12882 MYH1 S1482 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 S1102 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12883 MYH7 T1274 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12883 MYH7 S1478 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12956 XRCC6 S477 ochoa X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}.
P13533 MYH6 S1480 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13535 MYH8 T1277 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P13535 MYH8 S1481 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P14316 IRF2 S148 ochoa Interferon regulatory factor 2 (IRF-2) Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}.
P15924 DSP S1658 ochoa Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.
P16885 PLCG2 S1236 ochoa 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:0000269|PubMed:23000145}.
P18206 VCL S357 ochoa Vinculin (Metavinculin) (MV) Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.
P19338 NCL S482 ochoa Nucleolin (Protein C23) Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}.
P20700 LMNB1 S304 ochoa Lamin-B1 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}.
P21333 FLNA S108 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P22415 USF1 S262 psp Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1) Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
P30101 PDIA3 S474 ochoa Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}.
P31689 DNAJA1 S112 ochoa DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.
P31947 SFN S209 ochoa 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}.
P35749 MYH11 S998 ochoa Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) Muscle contraction.
P39748 FEN1 S210 ochoa Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}.
P42285 MTREX S687 ochoa Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase) Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension (PubMed:27871484, PubMed:29844170, PubMed:29906447). Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) (PubMed:21855801, PubMed:27871484, PubMed:29844170). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484, PubMed:29844170). PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand (PubMed:29844170). Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (PubMed:29906447). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:29107693, ECO:0000269|PubMed:29844170, ECO:0000269|PubMed:29902117, ECO:0000269|PubMed:29906447}.
P46060 RANGAP1 S24 ochoa Ran GTPase-activating protein 1 (RanGAP1) GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}.
P46939 UTRN S784 ochoa Utrophin (Dystrophin-related protein 1) (DRP-1) May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}.
P48552 NRIP1 S102 ochoa Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}.
P49908 SELENOP S266 ochoa Selenoprotein P (SeP) Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.
P52630 STAT2 S287 psp Signal transducer and activator of transcription 2 (p113) Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}.
P52630 STAT2 S734 psp Signal transducer and activator of transcription 2 (p113) Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}.
P52732 KIF11 T458 ochoa Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}.
P55198 MLLT6 T744 ochoa Protein AF-17 (ALL1-fused gene from chromosome 17 protein) None
P60228 EIF3E S412 ochoa Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924). {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMed:17468741, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
P61978 HNRNPK S127 ochoa Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}.
P62258 YWHAE S210 ochoa 14-3-3 protein epsilon (14-3-3E) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}.
P63104 YWHAZ S207 ochoa 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}.
P78345 RPP38 S226 ochoa Ribonuclease P protein subunit p38 (RNaseP protein p38) Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}.
P83916 CBX1 S129 ochoa Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000250|UniProtKB:P83917}.
Q00987 MDM2 S262 psp E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}.
Q01658 DR1 S105 ochoa Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}.
Q02818 NUCB1 S369 ochoa Nucleobindin-1 (CALNUC) Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}.
Q03252 LMNB2 S318 ochoa Lamin-B2 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}.
Q07912 TNK2 S529 ochoa Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}.
Q08209 PPP3CA S438 ochoa Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118). Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (PubMed:30718414). Negatively regulates SLC9A1 activity (PubMed:31375679). {ECO:0000250|UniProtKB:P48452, ECO:0000250|UniProtKB:P63328, ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:30254215, ECO:0000269|PubMed:30611118, ECO:0000269|PubMed:30718414, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:33691586}.
Q08378 GOLGA3 S467 ochoa Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) Golgi auto-antigen; probably involved in maintaining Golgi structure.
Q0ZGT2 NEXN S442 ochoa Nexilin (F-actin-binding protein) (Nelin) Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}.
Q13136 PPFIA1 S277 ochoa Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.
Q13136 PPFIA1 S448 ochoa Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.
Q13185 CBX3 S133 ochoa Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}.
Q13200 PSMD2 S46 ochoa 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
Q13416 ORC2 S284 ochoa Origin recognition complex subunit 2 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.
Q13506 NAB1 S356 ochoa NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. {ECO:0000250}.
Q13535 ATR S1333 psp Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:27723717, PubMed:27723720, PubMed:30139873, PubMed:33848395, PubMed:37788673, PubMed:37832547, PubMed:9427750, PubMed:9636169). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:23273981, PubMed:27723717, PubMed:27723720, PubMed:33848395, PubMed:9427750, PubMed:9636169). Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed:11418864, PubMed:11865061, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:9925639). Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism (PubMed:11673449). Required for FANCD2 ubiquitination (PubMed:15314022). Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (PubMed:12526805). Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2 (PubMed:30139873). Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress (PubMed:25083873, PubMed:37788673, PubMed:37832547). Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 (PubMed:25083873). Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly (PubMed:37832547). Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture (PubMed:37788673). The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity (PubMed:37788673). Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). {ECO:0000250|UniProtKB:Q9JKK8, ECO:0000269|PubMed:10597277, ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164, ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805, ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973, ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:25083873, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:33848395, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547, ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169, ECO:0000269|PubMed:9925639}.
Q13568 IRF5 S437 psp Interferon regulatory factor 5 (IRF-5) Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}.
Q14191 WRN S258 ochoa Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}.
Q14667 BLTP2 S1846 ochoa Bridge-like lipid transfer protein family member 2 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) (Protein hobbit homolog) Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution. {ECO:0000250|UniProtKB:Q9VZS7}.
Q14684 RRP1B S579 ochoa Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}.
Q14687 GSE1 S970 ochoa Genetic suppressor element 1 None
Q14789 GOLGB1 S491 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q14789 GOLGB1 S1753 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q14980 NUMA1 T1534 ochoa Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Q15046 KARS1 S207 psp Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:18029264, PubMed:18272479, PubMed:9278442). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:14975237, PubMed:19524539, PubMed:23159739, PubMed:5338216). {ECO:0000269|PubMed:14975237, ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:18029264, ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:28887846, ECO:0000269|PubMed:5338216, ECO:0000269|PubMed:9278442}.; FUNCTION: (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15220430}.
Q15075 EEA1 S354 ochoa Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
Q15276 RABEP1 S362 ochoa Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}.
Q15678 PTPN14 S463 ochoa Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}.
Q16204 CCDC6 T60 ochoa Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) None
Q16822 PCK2 S34 ochoa Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2) Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:28955899). Can play an active role in glyceroneogenesis and gluconeogenesis (PubMed:28955899). {ECO:0000269|PubMed:28955899}.
Q2KHM9 KIAA0753 S670 ochoa Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}.
Q2PPJ7 RALGAPA2 S1350 ochoa Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Q5H943 CT83 S85 ochoa Kita-kyushu lung cancer antigen 1 (KK-LC-1) (Cancer/testis antigen 83) None
Q5JR59 MTUS2 S1302 ochoa Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. {ECO:0000269|PubMed:19543227}.
Q5JTW2 CEP78 S453 ochoa Centrosomal protein of 78 kDa (Cep78) Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis (PubMed:27246242, PubMed:27588451, PubMed:28242748, PubMed:34259627). Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). Involved in cilium biogenesis and controls cilium length (PubMed:27588451). Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins (PubMed:28242748, PubMed:34259627). Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (By similarity). {ECO:0000250|UniProtKB:Q6IRU7, ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27588451, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.
Q5M775 SPECC1 S437 ochoa Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) None
Q5TZA2 CROCC S1900 ochoa Rootletin (Ciliary rootlet coiled-coil protein) Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}.
Q5VST9 OBSCN S2964 ochoa Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.
Q674X7 KAZN S20 ochoa Kazrin Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}.
Q6P0N0 MIS18BP1 T218 ochoa Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}.
Q6UWE0 LRSAM1 S290 ochoa E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}.
Q6UWE0 LRSAM1 S494 ochoa E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}.
Q6ZU80 CEP128 S797 ochoa Centrosomal protein of 128 kDa (Cep128) None
Q6ZVD8 PHLPP2 S307 ochoa PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}.
Q71DI3 H3C15 S87 ochoa Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q76FK4 NOL8 S421 ochoa Nucleolar protein 8 (Nucleolar protein Nop132) Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}.
Q7L590 MCM10 S26 ochoa Protein MCM10 homolog (HsMCM10) Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}.
Q7RTP6 MICAL3 S1586 ochoa [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}.
Q86SQ0 PHLDB2 S719 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86U44 METTL3 S243 ochoa N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}.
Q86YT6 MIB1 S416 ochoa E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.; FUNCTION: (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection. {ECO:0000269|PubMed:31851912}.
Q8IX03 WWC1 T1006 psp Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}.
Q8IYF3 TEX11 S178 ochoa Testis-expressed protein 11 (Protein ZIP4 homolog) (ZIP4H) Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. {ECO:0000250|UniProtKB:Q14AT2}.
Q8IYI6 EXOC8 S35 ochoa Exocyst complex component 8 (Exocyst complex 84 kDa subunit) Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Q8N4S0 CCDC82 S131 ochoa Coiled-coil domain-containing protein 82 None
Q8N4S0 CCDC82 S154 ochoa Coiled-coil domain-containing protein 82 None
Q8N680 ZBTB2 S178 ochoa Zinc finger and BTB domain-containing protein 2 May be involved in transcriptional regulation.
Q8ND76 CCNY S288 psp Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}.
Q8TB45 DEPTOR S168 psp DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}.
Q8TBA6 GOLGA5 S465 ochoa Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}.
Q8TBA6 GOLGA5 S585 ochoa Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}.
Q8TCU6 PREX1 S605 psp Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Q8TDX6 CSGALNACT1 S90 ochoa Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CsGalNAcT-1) (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1) (Beta4GalNAcT-1) Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758, PubMed:31705726). Moreover, is involved in the metabolism of aggrecan (By similarity). {ECO:0000250|UniProtKB:Q8BJQ9, ECO:0000269|PubMed:11788602, ECO:0000269|PubMed:12163485, ECO:0000269|PubMed:12446672, ECO:0000269|PubMed:17145758, ECO:0000269|PubMed:21160489, ECO:0000269|PubMed:27599773, ECO:0000269|PubMed:31705726}.
Q8WW22 DNAJA4 S113 ochoa DnaJ homolog subfamily A member 4 None
Q92734 TFG S99 ochoa Protein TFG (TRK-fused gene protein) Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}.
Q92783 STAM S191 ochoa Signal transducing adapter molecule 1 (STAM-1) Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.; FUNCTION: (Microbial infection) Plays an important role in Dengue virus entry. {ECO:0000269|PubMed:29742433}.
Q96JI7 SPG11 S1829 ochoa Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. {ECO:0000269|PubMed:24794856}.
Q96JQ2 CLMN S838 ochoa Calmin (Calponin-like transmembrane domain protein) None
Q96MR9 ZNF560 S169 ochoa Zinc finger protein 560 May be involved in transcriptional regulation.
Q96R06 SPAG5 S835 ochoa Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}.
Q96R06 SPAG5 S974 psp Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}.
Q96RR4 CAMKK2 S511 psp Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}.
Q96T51 RUFY1 S319 ochoa RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity). {ECO:0000250|UniProtKB:Q8BIJ7, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}.
Q99801 NKX3-1 S185 psp Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}.
Q9BQL6 FERMT1 S502 ochoa Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}.
Q9BRV8 SIKE1 S185 ochoa|psp Suppressor of IKBKE 1 (Suppressor of IKK-epsilon) Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (PubMed:16281057). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:30622739). {ECO:0000269|PubMed:16281057, ECO:0000269|PubMed:30622739}.
Q9BSW2 CRACR2A S263 ochoa EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46) (EC 3.6.5.2) [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269|PubMed:20418871, ECO:0000269|PubMed:27016526}.; FUNCTION: [Isoform 2]: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (PubMed:31092558). During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function (PubMed:31092558). Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (PubMed:30814157). Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526). In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (PubMed:27016526). Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160). Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (PubMed:27016526). {ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:29987160, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}.
Q9BV73 CEP250 S264 ochoa Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}.
Q9BXK5 BCL2L13 S50 ochoa Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) May promote the activation of caspase-3 and apoptosis.
Q9BY89 KIAA1671 S508 ochoa Uncharacterized protein KIAA1671 None
Q9BZF9 UACA S1353 ochoa Uveal autoantigen with coiled-coil domains and ankyrin repeats Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). {ECO:0000250}.; FUNCTION: Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity). {ECO:0000250|UniProtKB:Q8CGB3, ECO:0000250|UniProtKB:Q8HYY4}.
Q9C0B0 UNK S447 ochoa RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.
Q9H0A0 NAT10 S674 ochoa RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}.
Q9H5N1 RABEP2 S193 ochoa Rab GTPase-binding effector protein 2 (Rabaptin-5beta) Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062). {ECO:0000269|PubMed:27224062, ECO:0000269|PubMed:29425100, ECO:0000269|PubMed:9524116}.
Q9H8X2 IPPK S109 ochoa Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase) Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}.
Q9HBI1 PARVB S254 ochoa Beta-parvin (Affixin) Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}.
Q9HD20 ATP13A1 S935 ochoa Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). {ECO:0000269|PubMed:32973005, ECO:0000269|PubMed:36264797}.
Q9NPI6 DCP1A S545 ochoa mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}.
Q9NRA8 EIF4ENIF1 S417 ochoa Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}.
Q9NRA8 EIF4ENIF1 S541 ochoa Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}.
Q9NRD9 DUOX1 S634 ochoa Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 1) (Long NOX 1) (NADPH thyroid oxidase 1) (Thyroid oxidase 1) Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283}.
Q9P0K7 RAI14 S915 ochoa Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}.
Q9UBU7 DBF4 S420 ochoa Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}.
Q9UHY8 FEZ2 S195 ochoa Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) Involved in axonal outgrowth and fasciculation. {ECO:0000250}.
Q9UKF6 CPSF3 S659 ochoa Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73) Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease (PubMed:30507380). Also involved in the histone 3'-end pre-mRNA processing (PubMed:30507380). U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for entering/progressing through S-phase of the cell cycle (PubMed:30507380). Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). {ECO:0000250|UniProtKB:Q9QXK7, ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:15037765, ECO:0000269|PubMed:17128255, ECO:0000269|PubMed:18688255, ECO:0000269|PubMed:30507380}.
Q9UKL0 RCOR1 S127 ochoa REST corepressor 1 (Protein CoREST) Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}.
Q9UKV3 ACIN1 S135 ochoa Apoptotic chromatin condensation inducer in the nucleus (Acinus) Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}.
Q9UKX2 MYH2 T999 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX2 MYH2 S1245 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX2 MYH2 T1280 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX3 MYH13 S1482 ochoa Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}.
Q9ULD2 MTUS1 S958 ochoa Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
Q9ULD2 MTUS1 S1203 ochoa Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
Q9UQE7 SMC3 S292 ochoa Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}.
Q9Y210 TRPC6 S903 ochoa Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}.
Q9Y2F5 ICE1 S693 ochoa Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.
Q9Y490 TLN1 S1021 ochoa Talin-1 High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}.
Q9Y616 IRAK3 S332 ochoa Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}.
Q9Y623 MYH4 T997 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
Q9Y623 MYH4 S1482 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
Q9Y6K9 IKBKG S196 ochoa NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}.
P13489 RNH1 S290 Sugiyama Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625). {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889, ECO:0000269|PubMed:23843625, ECO:0000269|PubMed:3219362, ECO:0000269|PubMed:3243277, ECO:0000269|PubMed:32510170, ECO:0000269|PubMed:3470787, ECO:0000269|PubMed:9050852}.
P53675 CLTCL1 S460 Sugiyama Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.
Q00610 CLTC S460 Sugiyama Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
Q8NFD5 ARID1B S1744 Sugiyama AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B) (BRG1-associated factor 250b) (BAF250B) (BRG1-binding protein hELD/OSA1) (Osa homolog 2) (hOsa2) (p250R) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7, ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P12270 TPR S135 Sugiyama Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}.
Q8IX12 CCAR1 S1091 Sugiyama Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}.
Q9HB07 MYG1 S196 Sugiyama MYG1 exonuclease (EC 3.1.-.-) 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}.
O43252 PAPSS1 S231 Sugiyama Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:14747722, PubMed:9576487, PubMed:9648242, PubMed:9668121). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). {ECO:0000269|PubMed:14747722, ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242, ECO:0000269|PubMed:9668121}.
Q04917 YWHAH S38 Sugiyama 14-3-3 protein eta (Protein AS1) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.
P33176 KIF5B S443 Sugiyama Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}.
O60610 DIAPH1 T545 Sugiyama Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}.
O60763 USO1 S805 Sugiyama General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}.
O95721 SNAP29 S210 Sugiyama Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}.
Q6XUX3 DSTYK S337 Sugiyama Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}.
P22314 UBA1 S460 Sugiyama Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}.
Q9BQ39 DDX50 S145 Sugiyama ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}.
P01130 LDLR S286 Sugiyama Low-density lipoprotein receptor (LDL receptor) Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization (PubMed:30443021). {ECO:0000269|PubMed:3005267, ECO:0000269|PubMed:30443021, ECO:0000269|PubMed:6091915}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. {ECO:0000269|PubMed:10535997, ECO:0000269|PubMed:12615904}.; FUNCTION: (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. {ECO:0000269|PubMed:23589850}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. {ECO:0000269|PubMed:11100124}.; FUNCTION: (Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV). {ECO:0000269|PubMed:38182887}.; FUNCTION: (Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus. {ECO:0000269|PubMed:38245515}.
Download
reactome_id name p -log10_p
R-HSA-1640170 Cell Cycle 2.704839e-07 6.568
R-HSA-199991 Membrane Trafficking 5.698681e-06 5.244
R-HSA-69278 Cell Cycle, Mitotic 6.512103e-06 5.186
R-HSA-68886 M Phase 1.267994e-05 4.897
R-HSA-5357801 Programmed Cell Death 1.596110e-05 4.797
R-HSA-383280 Nuclear Receptor transcription pathway 2.814683e-05 4.551
R-HSA-69481 G2/M Checkpoints 3.040334e-05 4.517
R-HSA-109581 Apoptosis 4.387638e-05 4.358
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 9.664506e-05 4.015
R-HSA-111447 Activation of BAD and translocation to mitochondria 1.476346e-04 3.831
R-HSA-69620 Cell Cycle Checkpoints 1.333711e-04 3.875
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 1.476346e-04 3.831
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 1.476346e-04 3.831
R-HSA-5653656 Vesicle-mediated transport 1.812076e-04 3.742
R-HSA-111465 Apoptotic cleavage of cellular proteins 1.930364e-04 3.714
R-HSA-390522 Striated Muscle Contraction 2.440656e-04 3.612
R-HSA-68877 Mitotic Prometaphase 7.388222e-04 3.131
R-HSA-352238 Breakdown of the nuclear lamina 8.065171e-04 3.093
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 9.314490e-04 3.031
R-HSA-75153 Apoptotic execution phase 9.391488e-04 3.027
R-HSA-69473 G2/M DNA damage checkpoint 9.914958e-04 3.004
R-HSA-68884 Mitotic Telophase/Cytokinesis 1.200979e-03 2.920
R-HSA-1221632 Meiotic synapsis 1.600672e-03 2.796
R-HSA-114452 Activation of BH3-only proteins 1.590056e-03 2.799
R-HSA-1500620 Meiosis 1.866931e-03 2.729
R-HSA-109606 Intrinsic Pathway for Apoptosis 1.969630e-03 2.706
R-HSA-176187 Activation of ATR in response to replication stress 2.122076e-03 2.673
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 2.299106e-03 2.638
R-HSA-68875 Mitotic Prophase 2.607572e-03 2.584
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 3.067400e-03 2.513
R-HSA-380259 Loss of Nlp from mitotic centrosomes 3.067400e-03 2.513
R-HSA-432720 Lysosome Vesicle Biogenesis 3.007035e-03 2.522
R-HSA-2132295 MHC class II antigen presentation 2.943475e-03 2.531
R-HSA-8854518 AURKA Activation by TPX2 3.651868e-03 2.437
R-HSA-4419969 Depolymerization of the Nuclear Lamina 3.998667e-03 2.398
R-HSA-9854909 Regulation of MITF-M dependent genes involved in invasion 4.236870e-03 2.373
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 5.319669e-03 2.274
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 5.484779e-03 2.261
R-HSA-199992 trans-Golgi Network Vesicle Budding 5.053640e-03 2.296
R-HSA-380287 Centrosome maturation 5.881190e-03 2.231
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 6.143225e-03 2.212
R-HSA-9700206 Signaling by ALK in cancer 6.143225e-03 2.212
R-HSA-9692914 SARS-CoV-1-host interactions 5.904775e-03 2.229
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 6.217661e-03 2.206
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 6.880160e-03 2.162
R-HSA-9705683 SARS-CoV-2-host interactions 7.395438e-03 2.131
R-HSA-2470946 Cohesin Loading onto Chromatin 8.418839e-03 2.075
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 8.280052e-03 2.082
R-HSA-8863678 Neurodegenerative Diseases 8.280052e-03 2.082
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 8.930221e-03 2.049
R-HSA-69306 DNA Replication 9.483559e-03 2.023
R-HSA-196025 Formation of annular gap junctions 1.009672e-02 1.996
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 1.069969e-02 1.971
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 1.069969e-02 1.971
R-HSA-190873 Gap junction degradation 1.190981e-02 1.924
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 1.195106e-02 1.923
R-HSA-430116 GP1b-IX-V activation signalling 1.190981e-02 1.924
R-HSA-2980766 Nuclear Envelope Breakdown 1.247980e-02 1.904
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 1.251665e-02 1.903
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 1.385417e-02 1.858
R-HSA-68962 Activation of the pre-replicative complex 1.348725e-02 1.870
R-HSA-983189 Kinesins 1.449017e-02 1.839
R-HSA-182971 EGFR downregulation 1.449959e-02 1.839
R-HSA-9614399 Regulation of localization of FOXO transcription factors 1.592597e-02 1.798
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.617660e-02 1.791
R-HSA-1474165 Reproduction 1.556728e-02 1.808
R-HSA-397014 Muscle contraction 1.489057e-02 1.827
R-HSA-9730414 MITF-M-regulated melanocyte development 1.523886e-02 1.817
R-HSA-68882 Mitotic Anaphase 1.631925e-02 1.787
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.669139e-02 1.778
R-HSA-373755 Semaphorin interactions 1.669455e-02 1.777
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 1.774726e-02 1.751
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.827453e-02 1.738
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 2.129634e-02 1.672
R-HSA-69275 G2/M Transition 2.310415e-02 1.636
R-HSA-913531 Interferon Signaling 2.348843e-02 1.629
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 2.355900e-02 1.628
R-HSA-453274 Mitotic G2-G2/M phases 2.418604e-02 1.616
R-HSA-69002 DNA Replication Pre-Initiation 2.576034e-02 1.589
R-HSA-446353 Cell-extracellular matrix interactions 2.806734e-02 1.552
R-HSA-5617833 Cilium Assembly 2.530233e-02 1.597
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 2.806734e-02 1.552
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 3.082734e-02 1.511
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 3.141502e-02 1.503
R-HSA-909733 Interferon alpha/beta signaling 3.258505e-02 1.487
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 3.368999e-02 1.472
R-HSA-5210891 Uptake and function of anthrax toxins 3.665205e-02 1.436
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 3.665205e-02 1.436
R-HSA-3700989 Transcriptional Regulation by TP53 3.526825e-02 1.453
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 3.306534e-02 1.481
R-HSA-877300 Interferon gamma signaling 3.524002e-02 1.453
R-HSA-2028269 Signaling by Hippo 3.665205e-02 1.436
R-HSA-6802957 Oncogenic MAPK signaling 3.918485e-02 1.407
R-HSA-9613829 Chaperone Mediated Autophagy 3.971035e-02 1.401
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 3.998239e-02 1.398
R-HSA-5602636 IKBKB deficiency causes SCID 3.998239e-02 1.398
R-HSA-5620916 VxPx cargo-targeting to cilium 4.610323e-02 1.336
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 4.610323e-02 1.336
R-HSA-9645723 Diseases of programmed cell death 4.451545e-02 1.351
R-HSA-6807004 Negative regulation of MET activity 4.610323e-02 1.336
R-HSA-1280215 Cytokine Signaling in Immune system 4.393830e-02 1.357
R-HSA-381038 XBP1(S) activates chaperone genes 4.180178e-02 1.379
R-HSA-8964026 Chylomicron clearance 1.152355e-01 0.938
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 1.152355e-01 0.938
R-HSA-9632974 NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis 1.271938e-01 0.896
R-HSA-9700645 ALK mutants bind TKIs 1.506299e-01 0.822
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 1.621119e-01 0.790
R-HSA-164843 2-LTR circle formation 1.621119e-01 0.790
R-HSA-9615710 Late endosomal microautophagy 8.284568e-02 1.082
R-HSA-9709570 Impaired BRCA2 binding to RAD51 8.284568e-02 1.082
R-HSA-177504 Retrograde neurotrophin signalling 2.172454e-01 0.663
R-HSA-1295596 Spry regulation of FGF signaling 2.278308e-01 0.642
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 2.382738e-01 0.623
R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis 2.382738e-01 0.623
R-HSA-77595 Processing of Intronless Pre-mRNAs 2.485761e-01 0.605
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 2.587397e-01 0.587
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 1.302205e-01 0.885
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 1.347914e-01 0.870
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 1.393979e-01 0.856
R-HSA-9709603 Impaired BRCA2 binding to PALB2 2.786583e-01 0.555
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 2.884168e-01 0.540
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 2.884168e-01 0.540
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 2.884168e-01 0.540
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 2.884168e-01 0.540
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 2.884168e-01 0.540
R-HSA-72649 Translation initiation complex formation 2.067019e-01 0.685
R-HSA-3214815 HDACs deacetylate histones 2.116504e-01 0.674
R-HSA-72702 Ribosomal scanning and start codon recognition 2.166105e-01 0.664
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 2.365434e-01 0.626
R-HSA-72163 mRNA Splicing - Major Pathway 1.665070e-01 0.779
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 5.347022e-02 1.272
R-HSA-72172 mRNA Splicing 1.914447e-01 0.718
R-HSA-9646399 Aggrephagy 1.347914e-01 0.870
R-HSA-9842860 Regulation of endogenous retroelements 2.000281e-01 0.699
R-HSA-912694 Regulation of IFNA/IFNB signaling 3.169110e-01 0.499
R-HSA-6804757 Regulation of TP53 Degradation 1.167400e-01 0.933
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 1.389912e-01 0.857
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 2.065155e-01 0.685
R-HSA-432722 Golgi Associated Vesicle Biogenesis 5.143833e-02 1.289
R-HSA-2025928 Calcineurin activates NFAT 1.506299e-01 0.822
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 9.938054e-02 1.003
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 1.211929e-01 0.917
R-HSA-5674135 MAP2K and MAPK activation 1.440382e-01 0.842
R-HSA-6806003 Regulation of TP53 Expression and Degradation 1.302205e-01 0.885
R-HSA-68616 Assembly of the ORC complex at the origin of replication 9.938054e-02 1.003
R-HSA-8856828 Clathrin-mediated endocytosis 7.039903e-02 1.152
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 1.079658e-01 0.967
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 1.137519e-01 0.944
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 2.172454e-01 0.663
R-HSA-9656223 Signaling by RAF1 mutants 1.440382e-01 0.842
R-HSA-9649948 Signaling downstream of RAS mutants 1.676879e-01 0.775
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 1.676879e-01 0.775
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 1.676879e-01 0.775
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 2.570176e-01 0.590
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 1.079658e-01 0.967
R-HSA-5685942 HDR through Homologous Recombination (HRR) 2.716134e-01 0.566
R-HSA-69541 Stabilization of p53 1.302205e-01 0.885
R-HSA-5693538 Homology Directed Repair 2.678644e-01 0.572
R-HSA-68867 Assembly of the pre-replicative complex 1.662278e-01 0.779
R-HSA-5603029 IkBA variant leads to EDA-ID 1.031141e-01 0.987
R-HSA-68689 CDC6 association with the ORC:origin complex 1.031141e-01 0.987
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 1.506299e-01 0.822
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 1.621119e-01 0.790
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 1.846145e-01 0.734
R-HSA-8866427 VLDLR internalisation and degradation 1.956392e-01 0.709
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 2.065155e-01 0.685
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 2.065155e-01 0.685
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 2.172454e-01 0.663
R-HSA-399954 Sema3A PAK dependent Axon repulsion 2.278308e-01 0.642
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 2.278308e-01 0.642
R-HSA-6785631 ERBB2 Regulates Cell Motility 2.278308e-01 0.642
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 1.079658e-01 0.967
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 2.687665e-01 0.571
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 2.687665e-01 0.571
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 1.347914e-01 0.870
R-HSA-68949 Orc1 removal from chromatin 1.968448e-01 0.706
R-HSA-73772 RNA Polymerase I Promoter Escape 1.968448e-01 0.706
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 3.352731e-01 0.475
R-HSA-933542 TRAF6 mediated NF-kB activation 3.352731e-01 0.475
R-HSA-2467813 Separation of Sister Chromatids 1.043886e-01 0.981
R-HSA-3214858 RMTs methylate histone arginines 1.581450e-01 0.801
R-HSA-8964038 LDL clearance 5.633852e-02 1.249
R-HSA-6802949 Signaling by RAS mutants 1.676879e-01 0.775
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 2.916521e-01 0.535
R-HSA-8964043 Plasma lipoprotein clearance 1.302205e-01 0.885
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 1.031141e-01 0.987
R-HSA-174362 Transport and metabolism of PAPS 2.278308e-01 0.642
R-HSA-5099900 WNT5A-dependent internalization of FZD4 2.382738e-01 0.623
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 1.256870e-01 0.901
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 9.137207e-02 1.039
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 3.169110e-01 0.499
R-HSA-9766229 Degradation of CDH1 1.821783e-01 0.740
R-HSA-1169091 Activation of NF-kappaB in B cells 1.919387e-01 0.717
R-HSA-5578749 Transcriptional regulation by small RNAs 2.966528e-01 0.528
R-HSA-9764561 Regulation of CDH1 Function 5.988289e-02 1.223
R-HSA-204005 COPII-mediated vesicle transport 2.866470e-01 0.543
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 9.100126e-02 1.041
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 8.614846e-02 1.065
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 1.821783e-01 0.740
R-HSA-69563 p53-Dependent G1 DNA Damage Response 1.821783e-01 0.740
R-HSA-1236974 ER-Phagosome pathway 1.500266e-01 0.824
R-HSA-5693532 DNA Double-Strand Break Repair 2.051341e-01 0.688
R-HSA-205025 NADE modulates death signalling 7.837320e-02 1.106
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 2.278308e-01 0.642
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 2.485761e-01 0.605
R-HSA-8941858 Regulation of RUNX3 expression and activity 1.347914e-01 0.870
R-HSA-9604323 Negative regulation of NOTCH4 signaling 1.347914e-01 0.870
R-HSA-937041 IKK complex recruitment mediated by RIP1 2.786583e-01 0.555
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 2.980439e-01 0.526
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 2.980439e-01 0.526
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 1.676879e-01 0.775
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 3.352731e-01 0.475
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 2.265608e-01 0.645
R-HSA-8868773 rRNA processing in the nucleus and cytosol 1.534902e-01 0.814
R-HSA-177243 Interactions of Rev with host cellular proteins 1.347914e-01 0.870
R-HSA-8953854 Metabolism of RNA 7.732308e-02 1.112
R-HSA-400685 Sema4D in semaphorin signaling 6.728073e-02 1.172
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 1.389912e-01 0.857
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 1.506299e-01 0.822
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 1.256870e-01 0.901
R-HSA-6811438 Intra-Golgi traffic 1.440382e-01 0.842
R-HSA-69052 Switching of origins to a post-replicative state 3.016483e-01 0.520
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 2.192389e-01 0.659
R-HSA-174414 Processive synthesis on the C-strand of the telomere 7.493237e-02 1.125
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 1.123303e-01 0.950
R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 2.587397e-01 0.587
R-HSA-392517 Rap1 signalling 2.786583e-01 0.555
R-HSA-6784531 tRNA processing in the nucleus 2.465495e-01 0.608
R-HSA-9758274 Regulation of NF-kappa B signaling 2.382738e-01 0.623
R-HSA-9018519 Estrogen-dependent gene expression 5.934302e-02 1.227
R-HSA-69615 G1/S DNA Damage Checkpoints 2.515587e-01 0.599
R-HSA-5633007 Regulation of TP53 Activity 2.249532e-01 0.648
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 1.629037e-01 0.788
R-HSA-76002 Platelet activation, signaling and aggregation 1.085801e-01 0.964
R-HSA-937039 IRAK1 recruits IKK complex 1.956392e-01 0.709
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 1.956392e-01 0.709
R-HSA-418890 Role of second messengers in netrin-1 signaling 1.956392e-01 0.709
R-HSA-3928663 EPHA-mediated growth cone collapse 7.493237e-02 1.125
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 8.284568e-02 1.082
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 2.172454e-01 0.663
R-HSA-69166 Removal of the Flap Intermediate 2.172454e-01 0.663
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 2.278308e-01 0.642
R-HSA-445355 Smooth Muscle Contraction 5.143833e-02 1.289
R-HSA-113510 E2F mediated regulation of DNA replication 2.786583e-01 0.555
R-HSA-9924644 Developmental Lineages of the Mammary Gland 9.672431e-02 1.014
R-HSA-429947 Deadenylation of mRNA 3.352731e-01 0.475
R-HSA-5607764 CLEC7A (Dectin-1) signaling 5.952772e-02 1.225
R-HSA-5620920 Cargo trafficking to the periciliary membrane 2.916521e-01 0.535
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 1.621119e-01 0.790
R-HSA-72312 rRNA processing 2.600313e-01 0.585
R-HSA-2022870 CS-GAG biosynthesis 3.075414e-01 0.512
R-HSA-162592 Integration of provirus 1.846145e-01 0.734
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 2.000281e-01 0.699
R-HSA-73933 Resolution of Abasic Sites (AP sites) 1.393979e-01 0.856
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 2.533052e-01 0.596
R-HSA-5621481 C-type lectin receptors (CLRs) 2.599792e-01 0.585
R-HSA-162909 Host Interactions of HIV factors 1.205388e-01 0.919
R-HSA-9020702 Interleukin-1 signaling 1.965747e-01 0.706
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 1.506299e-01 0.822
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 1.734395e-01 0.761
R-HSA-399956 CRMPs in Sema3A signaling 2.172454e-01 0.663
R-HSA-3270619 IRF3-mediated induction of type I IFN 2.278308e-01 0.642
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 2.382738e-01 0.623
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 2.587397e-01 0.587
R-HSA-139853 Elevation of cytosolic Ca2+ levels 2.587397e-01 0.587
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 2.786583e-01 0.555
R-HSA-190828 Gap junction trafficking 1.581450e-01 0.801
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 3.075414e-01 0.512
R-HSA-416482 G alpha (12/13) signalling events 1.135138e-01 0.945
R-HSA-429914 Deadenylation-dependent mRNA decay 2.315486e-01 0.635
R-HSA-1236975 Antigen processing-Cross presentation 2.245812e-01 0.649
R-HSA-73854 RNA Polymerase I Promoter Clearance 3.165958e-01 0.499
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 2.687665e-01 0.571
R-HSA-69242 S Phase 7.784749e-02 1.109
R-HSA-114608 Platelet degranulation 1.298523e-01 0.887
R-HSA-177929 Signaling by EGFR 5.771405e-02 1.239
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 1.135138e-01 0.945
R-HSA-1852241 Organelle biogenesis and maintenance 1.831849e-01 0.737
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 1.751418e-01 0.757
R-HSA-1280218 Adaptive Immune System 2.850044e-01 0.545
R-HSA-1483249 Inositol phosphate metabolism 2.388681e-01 0.622
R-HSA-9627069 Regulation of the apoptosome activity 1.621119e-01 0.790
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 1.956392e-01 0.709
R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 1.956392e-01 0.709
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 2.065155e-01 0.685
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 2.278308e-01 0.642
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 2.382738e-01 0.623
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 2.587397e-01 0.587
R-HSA-1614517 Sulfide oxidation to sulfate 2.587397e-01 0.587
R-HSA-157858 Gap junction trafficking and regulation 1.821783e-01 0.740
R-HSA-8856688 Golgi-to-ER retrograde transport 5.297623e-02 1.276
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 2.245812e-01 0.649
R-HSA-4086400 PCP/CE pathway 3.265213e-01 0.486
R-HSA-69206 G1/S Transition 1.251585e-01 0.903
R-HSA-73886 Chromosome Maintenance 2.788477e-01 0.555
R-HSA-8939211 ESR-mediated signaling 2.728728e-01 0.564
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 9.672431e-02 1.014
R-HSA-3000171 Non-integrin membrane-ECM interactions 3.116205e-01 0.506
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 3.261543e-01 0.487
R-HSA-5689880 Ub-specific processing proteases 1.229747e-01 0.910
R-HSA-9013694 Signaling by NOTCH4 3.066377e-01 0.513
R-HSA-74160 Gene expression (Transcription) 1.798681e-01 0.745
R-HSA-69239 Synthesis of DNA 2.210363e-01 0.656
R-HSA-9675135 Diseases of DNA repair 1.676879e-01 0.775
R-HSA-69183 Processive synthesis on the lagging strand 2.278308e-01 0.642
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 5.988289e-02 1.223
R-HSA-193648 NRAGE signals death through JNK 2.166105e-01 0.664
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 1.468397e-01 0.833
R-HSA-73864 RNA Polymerase I Transcription 3.265213e-01 0.486
R-HSA-5688426 Deubiquitination 1.740830e-01 0.759
R-HSA-446652 Interleukin-1 family signaling 8.410041e-02 1.075
R-HSA-9679191 Potential therapeutics for SARS 1.968051e-01 0.706
R-HSA-3371556 Cellular response to heat stress 2.788477e-01 0.555
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 1.123303e-01 0.950
R-HSA-110357 Displacement of DNA glycosylase by APEX1 1.271938e-01 0.896
R-HSA-8849932 Synaptic adhesion-like molecules 2.687665e-01 0.571
R-HSA-1169408 ISG15 antiviral mechanism 3.116205e-01 0.506
R-HSA-109582 Hemostasis 2.090220e-01 0.680
R-HSA-264876 Insulin processing 7.493237e-02 1.125
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 9.944747e-02 1.002
R-HSA-198323 AKT phosphorylates targets in the cytosol 1.956392e-01 0.709
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 1.036485e-01 0.984
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 1.440382e-01 0.842
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 1.724960e-01 0.763
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 6.422549e-02 1.192
R-HSA-168898 Toll-like Receptor Cascades 1.599441e-01 0.796
R-HSA-162594 Early Phase of HIV Life Cycle 4.943178e-02 1.306
R-HSA-73857 RNA Polymerase II Transcription 1.297268e-01 0.887
R-HSA-168256 Immune System 1.622046e-01 0.790
R-HSA-212436 Generic Transcription Pathway 1.241995e-01 0.906
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 1.389912e-01 0.857
R-HSA-111458 Formation of apoptosome 1.621119e-01 0.790
R-HSA-9842663 Signaling by LTK 1.956392e-01 0.709
R-HSA-1855191 Synthesis of IPs in the nucleus 2.172454e-01 0.663
R-HSA-9836573 Mitochondrial RNA degradation 3.352731e-01 0.475
R-HSA-453279 Mitotic G1 phase and G1/S transition 1.858694e-01 0.731
R-HSA-9764265 Regulation of CDH1 Expression and Function 2.659224e-01 0.575
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 2.659224e-01 0.575
R-HSA-9675108 Nervous system development 2.009193e-01 0.697
R-HSA-202403 TCR signaling 2.317041e-01 0.635
R-HSA-162906 HIV Infection 1.227732e-01 0.911
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 8.689437e-02 1.061
R-HSA-918233 TRAF3-dependent IRF activation pathway 2.485761e-01 0.605
R-HSA-69186 Lagging Strand Synthesis 2.980439e-01 0.526
R-HSA-5339562 Uptake and actions of bacterial toxins 1.968448e-01 0.706
R-HSA-111461 Cytochrome c-mediated apoptotic response 1.846145e-01 0.734
R-HSA-6804760 Regulation of TP53 Activity through Methylation 2.687665e-01 0.571
R-HSA-9012852 Signaling by NOTCH3 5.558343e-02 1.255
R-HSA-446728 Cell junction organization 2.217613e-01 0.654
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 2.866470e-01 0.543
R-HSA-9824446 Viral Infection Pathways 6.633140e-02 1.178
R-HSA-9860931 Response of endothelial cells to shear stress 2.069779e-01 0.684
R-HSA-162582 Signal Transduction 8.515690e-02 1.070
R-HSA-8876384 Listeria monocytogenes entry into host cells 5.284450e-02 1.277
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 2.980439e-01 0.526
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.405662e-01 0.852
R-HSA-2262752 Cellular responses to stress 1.751219e-01 0.757
R-HSA-5218859 Regulated Necrosis 2.766268e-01 0.558
R-HSA-8953897 Cellular responses to stimuli 1.697937e-01 0.770
R-HSA-9008059 Interleukin-37 signaling 8.689437e-02 1.061
R-HSA-2682334 EPH-Ephrin signaling 5.172192e-02 1.286
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 3.169110e-01 0.499
R-HSA-180786 Extension of Telomeres 2.315486e-01 0.635
R-HSA-9856651 MITF-M-dependent gene expression 1.968051e-01 0.706
R-HSA-1500931 Cell-Cell communication 3.082081e-01 0.511
R-HSA-5663205 Infectious disease 1.763224e-01 0.754
R-HSA-8983711 OAS antiviral response 1.956392e-01 0.709
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 3.169110e-01 0.499
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 3.261543e-01 0.487
R-HSA-157118 Signaling by NOTCH 1.455727e-01 0.837
R-HSA-9855142 Cellular responses to mechanical stimuli 2.460696e-01 0.609
R-HSA-162587 HIV Life Cycle 2.163968e-01 0.665
R-HSA-5628897 TP53 Regulates Metabolic Genes 9.860936e-02 1.006
R-HSA-9768919 NPAS4 regulates expression of target genes 1.079658e-01 0.967
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 2.079334e-01 0.682
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 3.261543e-01 0.487
R-HSA-8854691 Interleukin-20 family signaling 3.261543e-01 0.487
R-HSA-1834941 STING mediated induction of host immune responses 2.786583e-01 0.555
R-HSA-73887 Death Receptor Signaling 2.079334e-01 0.682
R-HSA-9694516 SARS-CoV-2 Infection 6.702242e-02 1.174
R-HSA-449147 Signaling by Interleukins 1.724778e-01 0.763
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 1.581450e-01 0.801
R-HSA-9679506 SARS-CoV Infections 9.637948e-02 1.016
R-HSA-9634815 Transcriptional Regulation by NPAS4 1.968448e-01 0.706
R-HSA-193704 p75 NTR receptor-mediated signalling 1.897134e-01 0.722
R-HSA-381070 IRE1alpha activates chaperones 5.023249e-02 1.299
R-HSA-111471 Apoptotic factor-mediated response 2.687665e-01 0.571
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 2.615844e-01 0.582
R-HSA-381119 Unfolded Protein Response (UPR) 1.646379e-01 0.783
R-HSA-9678108 SARS-CoV-1 Infection 5.082154e-02 1.294
R-HSA-9020591 Interleukin-12 signaling 3.165958e-01 0.499
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 3.356259e-01 0.474
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 3.364087e-01 0.473
R-HSA-6806834 Signaling by MET 3.364087e-01 0.473
R-HSA-5693607 Processing of DNA double-strand break ends 3.413366e-01 0.467
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 3.442691e-01 0.463
R-HSA-3214842 HDMs demethylate histones 3.442691e-01 0.463
R-HSA-9932444 ATP-dependent chromatin remodelers 3.442691e-01 0.463
R-HSA-9932451 SWI/SNF chromatin remodelers 3.442691e-01 0.463
R-HSA-1266695 Interleukin-7 signaling 3.442691e-01 0.463
R-HSA-3858494 Beta-catenin independent WNT signaling 3.452825e-01 0.462
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 3.462531e-01 0.461
R-HSA-9703465 Signaling by FLT3 fusion proteins 3.531439e-01 0.452
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 3.531439e-01 0.452
R-HSA-5689901 Metalloprotease DUBs 3.531439e-01 0.452
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 3.531439e-01 0.452
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 3.531439e-01 0.452
R-HSA-3295583 TRP channels 3.531439e-01 0.452
R-HSA-70635 Urea cycle 3.531439e-01 0.452
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 3.531439e-01 0.452
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 3.560495e-01 0.448
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 3.570935e-01 0.447
R-HSA-6794362 Protein-protein interactions at synapses 3.609283e-01 0.443
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 3.618991e-01 0.441
R-HSA-73728 RNA Polymerase I Promoter Opening 3.618991e-01 0.441
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 3.618991e-01 0.441
R-HSA-422475 Axon guidance 3.645466e-01 0.438
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 3.657935e-01 0.437
R-HSA-141424 Amplification of signal from the kinetochores 3.657935e-01 0.437
R-HSA-5654732 Negative regulation of FGFR3 signaling 3.705363e-01 0.431
R-HSA-9619483 Activation of AMPK downstream of NMDARs 3.705363e-01 0.431
R-HSA-9638334 Iron assimilation using enterobactin 3.705363e-01 0.431
R-HSA-5620971 Pyroptosis 3.705363e-01 0.431
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 3.705363e-01 0.431
R-HSA-447115 Interleukin-12 family signaling 3.754808e-01 0.425
R-HSA-1643685 Disease 3.761809e-01 0.425
R-HSA-5334118 DNA methylation 3.790572e-01 0.421
R-HSA-5654733 Negative regulation of FGFR4 signaling 3.790572e-01 0.421
R-HSA-209968 Thyroxine biosynthesis 3.790572e-01 0.421
R-HSA-180024 DARPP-32 events 3.790572e-01 0.421
R-HSA-418360 Platelet calcium homeostasis 3.790572e-01 0.421
R-HSA-9006335 Signaling by Erythropoietin 3.790572e-01 0.421
R-HSA-9663891 Selective autophagy 3.803020e-01 0.420
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 3.874632e-01 0.412
R-HSA-2424491 DAP12 signaling 3.874632e-01 0.412
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 3.874632e-01 0.412
R-HSA-199977 ER to Golgi Anterograde Transport 3.893914e-01 0.410
R-HSA-202424 Downstream TCR signaling 3.898970e-01 0.409
R-HSA-73884 Base Excision Repair 3.898970e-01 0.409
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 3.930398e-01 0.406
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 3.957560e-01 0.403
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 3.957560e-01 0.403
R-HSA-9820960 Respiratory syncytial virus (RSV) attachment and entry 3.957560e-01 0.403
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 3.957560e-01 0.403
R-HSA-399719 Trafficking of AMPA receptors 3.957560e-01 0.403
R-HSA-9833109 Evasion by RSV of host interferon responses 3.957560e-01 0.403
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 4.039370e-01 0.394
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 4.039370e-01 0.394
R-HSA-69190 DNA strand elongation 4.039370e-01 0.394
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 4.041644e-01 0.393
R-HSA-418990 Adherens junctions interactions 4.060490e-01 0.391
R-HSA-1855170 IPs transport between nucleus and cytosol 4.120077e-01 0.385
R-HSA-159227 Transport of the SLBP independent Mature mRNA 4.120077e-01 0.385
R-HSA-354192 Integrin signaling 4.120077e-01 0.385
R-HSA-9930044 Nuclear RNA decay 4.120077e-01 0.385
R-HSA-5654726 Negative regulation of FGFR1 signaling 4.120077e-01 0.385
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 4.120077e-01 0.385
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 4.120077e-01 0.385
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 4.120077e-01 0.385
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 4.120077e-01 0.385
R-HSA-5675482 Regulation of necroptotic cell death 4.120077e-01 0.385
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 4.120077e-01 0.385
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 4.182720e-01 0.379
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 4.199696e-01 0.377
R-HSA-5693537 Resolution of D-Loop Structures 4.199696e-01 0.377
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 4.199696e-01 0.377
R-HSA-180534 Vpu mediated degradation of CD4 4.199696e-01 0.377
R-HSA-114508 Effects of PIP2 hydrolysis 4.199696e-01 0.377
R-HSA-72689 Formation of a pool of free 40S subunits 4.229373e-01 0.374
R-HSA-9610379 HCMV Late Events 4.255983e-01 0.371
R-HSA-6807878 COPI-mediated anterograde transport 4.275833e-01 0.369
R-HSA-5654727 Negative regulation of FGFR2 signaling 4.278242e-01 0.369
R-HSA-168638 NOD1/2 Signaling Pathway 4.278242e-01 0.369
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 4.278242e-01 0.369
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 4.278242e-01 0.369
R-HSA-180746 Nuclear import of Rev protein 4.278242e-01 0.369
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 4.278242e-01 0.369
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 4.278242e-01 0.369
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 4.278242e-01 0.369
R-HSA-901042 Calnexin/calreticulin cycle 4.278242e-01 0.369
R-HSA-1980145 Signaling by NOTCH2 4.278242e-01 0.369
R-HSA-8878159 Transcriptional regulation by RUNX3 4.322097e-01 0.364
R-HSA-157579 Telomere Maintenance 4.322097e-01 0.364
R-HSA-195721 Signaling by WNT 4.349700e-01 0.362
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 4.355729e-01 0.361
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 4.355729e-01 0.361
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 4.355729e-01 0.361
R-HSA-169911 Regulation of Apoptosis 4.355729e-01 0.361
R-HSA-2559585 Oncogene Induced Senescence 4.355729e-01 0.361
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 4.355729e-01 0.361
R-HSA-3214847 HATs acetylate histones 4.414026e-01 0.355
R-HSA-9614085 FOXO-mediated transcription 4.414026e-01 0.355
R-HSA-212300 PRC2 methylates histones and DNA 4.432172e-01 0.353
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 4.432172e-01 0.353
R-HSA-180585 Vif-mediated degradation of APOBEC3G 4.432172e-01 0.353
R-HSA-9682385 FLT3 signaling in disease 4.432172e-01 0.353
R-HSA-3371511 HSF1 activation 4.432172e-01 0.353
R-HSA-111933 Calmodulin induced events 4.432172e-01 0.353
R-HSA-111997 CaM pathway 4.432172e-01 0.353
R-HSA-114604 GPVI-mediated activation cascade 4.432172e-01 0.353
R-HSA-8941326 RUNX2 regulates bone development 4.432172e-01 0.353
R-HSA-69618 Mitotic Spindle Checkpoint 4.459685e-01 0.351
R-HSA-5610787 Hedgehog 'off' state 4.459685e-01 0.351
R-HSA-2408522 Selenoamino acid metabolism 4.505029e-01 0.346
R-HSA-427359 SIRT1 negatively regulates rRNA expression 4.507584e-01 0.346
R-HSA-180910 Vpr-mediated nuclear import of PICs 4.507584e-01 0.346
R-HSA-110331 Cleavage of the damaged purine 4.507584e-01 0.346
R-HSA-4641258 Degradation of DVL 4.507584e-01 0.346
R-HSA-4641257 Degradation of AXIN 4.507584e-01 0.346
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 4.507584e-01 0.346
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 4.507584e-01 0.346
R-HSA-933541 TRAF6 mediated IRF7 activation 4.507584e-01 0.346
R-HSA-5689896 Ovarian tumor domain proteases 4.507584e-01 0.346
R-HSA-196757 Metabolism of folate and pterines 4.507584e-01 0.346
R-HSA-3247509 Chromatin modifying enzymes 4.542767e-01 0.343
R-HSA-2559580 Oxidative Stress Induced Senescence 4.550377e-01 0.342
R-HSA-73927 Depurination 4.581979e-01 0.339
R-HSA-5213460 RIPK1-mediated regulated necrosis 4.581979e-01 0.339
R-HSA-111885 Opioid Signalling 4.640216e-01 0.333
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 4.655371e-01 0.332
R-HSA-8953750 Transcriptional Regulation by E2F6 4.655371e-01 0.332
R-HSA-168276 NS1 Mediated Effects on Host Pathways 4.655371e-01 0.332
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 4.655371e-01 0.332
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 4.655371e-01 0.332
R-HSA-983169 Class I MHC mediated antigen processing & presentation 4.711928e-01 0.327
R-HSA-176033 Interactions of Vpr with host cellular proteins 4.727773e-01 0.325
R-HSA-5602358 Diseases associated with the TLR signaling cascade 4.727773e-01 0.325
R-HSA-5260271 Diseases of Immune System 4.727773e-01 0.325
R-HSA-202433 Generation of second messenger molecules 4.727773e-01 0.325
R-HSA-379726 Mitochondrial tRNA aminoacylation 4.727773e-01 0.325
R-HSA-6798695 Neutrophil degranulation 4.747842e-01 0.324
R-HSA-3214841 PKMTs methylate histone lysines 4.799199e-01 0.319
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 4.799199e-01 0.319
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 4.799199e-01 0.319
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 4.799199e-01 0.319
R-HSA-5362768 Hh mutants are degraded by ERAD 4.799199e-01 0.319
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 4.799199e-01 0.319
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 4.799199e-01 0.319
R-HSA-211000 Gene Silencing by RNA 4.817261e-01 0.317
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 4.860961e-01 0.313
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 4.860961e-01 0.313
R-HSA-9932298 Degradation of CRY and PER proteins 4.869662e-01 0.313
R-HSA-5610780 Degradation of GLI1 by the proteasome 4.869662e-01 0.313
R-HSA-5610783 Degradation of GLI2 by the proteasome 4.869662e-01 0.313
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 4.869662e-01 0.313
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 4.904432e-01 0.309
R-HSA-379716 Cytosolic tRNA aminoacylation 4.939174e-01 0.306
R-HSA-111996 Ca-dependent events 4.939174e-01 0.306
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 4.939174e-01 0.306
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 4.953607e-01 0.305
R-HSA-4839726 Chromatin organization 4.982939e-01 0.303
R-HSA-212165 Epigenetic regulation of gene expression 5.001921e-01 0.301
R-HSA-9710421 Defective pyroptosis 5.007749e-01 0.300
R-HSA-5654743 Signaling by FGFR4 5.007749e-01 0.300
R-HSA-5387390 Hh mutants abrogate ligand secretion 5.007749e-01 0.300
R-HSA-8854214 TBC/RABGAPs 5.007749e-01 0.300
R-HSA-1433557 Signaling by SCF-KIT 5.007749e-01 0.300
R-HSA-9609646 HCMV Infection 5.011765e-01 0.300
R-HSA-927802 Nonsense-Mediated Decay (NMD) 5.033457e-01 0.298
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 5.033457e-01 0.298
R-HSA-421270 Cell-cell junction organization 5.040520e-01 0.298
R-HSA-168255 Influenza Infection 5.056596e-01 0.296
R-HSA-2172127 DAP12 interactions 5.075398e-01 0.295
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 5.075398e-01 0.295
R-HSA-9907900 Proteasome assembly 5.075398e-01 0.295
R-HSA-3928662 EPHB-mediated forward signaling 5.075398e-01 0.295
R-HSA-373752 Netrin-1 signaling 5.075398e-01 0.295
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 5.075996e-01 0.294
R-HSA-2559583 Cellular Senescence 5.090138e-01 0.293
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 5.118299e-01 0.291
R-HSA-774815 Nucleosome assembly 5.142136e-01 0.289
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 5.142136e-01 0.289
R-HSA-76009 Platelet Aggregation (Plug Formation) 5.142136e-01 0.289
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 5.142136e-01 0.289
R-HSA-5654741 Signaling by FGFR3 5.142136e-01 0.289
R-HSA-4608870 Asymmetric localization of PCP proteins 5.142136e-01 0.289
R-HSA-6783310 Fanconi Anemia Pathway 5.142136e-01 0.289
R-HSA-5678895 Defective CFTR causes cystic fibrosis 5.142136e-01 0.289
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 5.142136e-01 0.289
R-HSA-1489509 DAG and IP3 signaling 5.142136e-01 0.289
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 5.142136e-01 0.289
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 5.142136e-01 0.289
R-HSA-9824272 Somitogenesis 5.142136e-01 0.289
R-HSA-1614558 Degradation of cysteine and homocysteine 5.142136e-01 0.289
R-HSA-201681 TCF dependent signaling in response to WNT 5.190049e-01 0.285
R-HSA-2299718 Condensation of Prophase Chromosomes 5.207972e-01 0.283
R-HSA-72165 mRNA Splicing - Minor Pathway 5.207972e-01 0.283
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 5.207972e-01 0.283
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 5.207972e-01 0.283
R-HSA-5357905 Regulation of TNFR1 signaling 5.207972e-01 0.283
R-HSA-2871809 FCERI mediated Ca+2 mobilization 5.243774e-01 0.280
R-HSA-437239 Recycling pathway of L1 5.272921e-01 0.278
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 5.272921e-01 0.278
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 5.272921e-01 0.278
R-HSA-72737 Cap-dependent Translation Initiation 5.285117e-01 0.277
R-HSA-72613 Eukaryotic Translation Initiation 5.285117e-01 0.277
R-HSA-9007101 Rab regulation of trafficking 5.326217e-01 0.274
R-HSA-70326 Glucose metabolism 5.326217e-01 0.274
R-HSA-2980736 Peptide hormone metabolism 5.326217e-01 0.274
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 5.336993e-01 0.273
R-HSA-70263 Gluconeogenesis 5.336993e-01 0.273
R-HSA-9031628 NGF-stimulated transcription 5.336993e-01 0.273
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 5.400201e-01 0.268
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 5.407684e-01 0.267
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 5.407684e-01 0.267
R-HSA-8878166 Transcriptional regulation by RUNX2 5.407684e-01 0.267
R-HSA-5658442 Regulation of RAS by GAPs 5.462555e-01 0.263
R-HSA-9006925 Intracellular signaling by second messengers 5.477968e-01 0.261
R-HSA-912446 Meiotic recombination 5.524069e-01 0.258
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 5.524069e-01 0.258
R-HSA-5358346 Hedgehog ligand biogenesis 5.524069e-01 0.258
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 5.528041e-01 0.257
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 5.528041e-01 0.257
R-HSA-9816359 Maternal to zygotic transition (MZT) 5.567664e-01 0.254
R-HSA-72187 mRNA 3'-end processing 5.584752e-01 0.253
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 5.584752e-01 0.253
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 5.584752e-01 0.253
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 5.584752e-01 0.253
R-HSA-6809371 Formation of the cornified envelope 5.607040e-01 0.251
R-HSA-9609690 HCMV Early Events 5.609931e-01 0.251
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 5.644616e-01 0.248
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 5.644616e-01 0.248
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 5.644616e-01 0.248
R-HSA-8948751 Regulation of PTEN stability and activity 5.644616e-01 0.248
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 5.703672e-01 0.244
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 5.703672e-01 0.244
R-HSA-73929 Base-Excision Repair, AP Site Formation 5.703672e-01 0.244
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 5.761931e-01 0.239
R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism 5.761931e-01 0.239
R-HSA-948021 Transport to the Golgi and subsequent modification 5.796153e-01 0.237
R-HSA-187037 Signaling by NTRK1 (TRKA) 5.800171e-01 0.237
R-HSA-209776 Metabolism of amine-derived hormones 5.819403e-01 0.235
R-HSA-5654736 Signaling by FGFR1 5.819403e-01 0.235
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 5.819403e-01 0.235
R-HSA-75893 TNF signaling 5.819403e-01 0.235
R-HSA-5621480 Dectin-2 family 5.876100e-01 0.231
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 5.891779e-01 0.230
R-HSA-73894 DNA Repair 5.908352e-01 0.229
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 5.932031e-01 0.227
R-HSA-9006931 Signaling by Nuclear Receptors 5.977896e-01 0.223
R-HSA-9909396 Circadian clock 5.987031e-01 0.223
R-HSA-194441 Metabolism of non-coding RNA 5.987207e-01 0.223
R-HSA-191859 snRNP Assembly 5.987207e-01 0.223
R-HSA-379724 tRNA Aminoacylation 6.041638e-01 0.219
R-HSA-8943724 Regulation of PTEN gene transcription 6.041638e-01 0.219
R-HSA-2644603 Signaling by NOTCH1 in Cancer 6.041638e-01 0.219
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 6.041638e-01 0.219
R-HSA-351202 Metabolism of polyamines 6.041638e-01 0.219
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 6.041638e-01 0.219
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 6.041638e-01 0.219
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 6.041638e-01 0.219
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 6.041638e-01 0.219
R-HSA-1227986 Signaling by ERBB2 6.041638e-01 0.219
R-HSA-73856 RNA Polymerase II Transcription Termination 6.095334e-01 0.215
R-HSA-168325 Viral Messenger RNA Synthesis 6.095334e-01 0.215
R-HSA-450294 MAP kinase activation 6.095334e-01 0.215
R-HSA-8939902 Regulation of RUNX2 expression and activity 6.095334e-01 0.215
R-HSA-112043 PLC beta mediated events 6.095334e-01 0.215
R-HSA-9793380 Formation of paraxial mesoderm 6.095334e-01 0.215
R-HSA-1268020 Mitochondrial protein import 6.148305e-01 0.211
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 6.148305e-01 0.211
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 6.148305e-01 0.211
R-HSA-9707616 Heme signaling 6.148305e-01 0.211
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 6.148305e-01 0.211
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 6.148305e-01 0.211
R-HSA-9616222 Transcriptional regulation of granulopoiesis 6.148305e-01 0.211
R-HSA-6790901 rRNA modification in the nucleus and cytosol 6.200560e-01 0.208
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 6.202970e-01 0.207
R-HSA-1257604 PIP3 activates AKT signaling 6.222526e-01 0.206
R-HSA-9948299 Ribosome-associated quality control 6.238081e-01 0.205
R-HSA-5358351 Signaling by Hedgehog 6.238081e-01 0.205
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 6.252110e-01 0.204
R-HSA-936837 Ion transport by P-type ATPases 6.252110e-01 0.204
R-HSA-6807070 PTEN Regulation 6.272942e-01 0.203
R-HSA-1234174 Cellular response to hypoxia 6.302963e-01 0.200
R-HSA-1632852 Macroautophagy 6.341914e-01 0.198
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 6.353130e-01 0.197
R-HSA-112040 G-protein mediated events 6.402619e-01 0.194
R-HSA-162599 Late Phase of HIV Life Cycle 6.409890e-01 0.193
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 6.451439e-01 0.190
R-HSA-2871837 FCERI mediated NF-kB activation 6.476872e-01 0.189
R-HSA-8878171 Transcriptional regulation by RUNX1 6.516895e-01 0.186
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 6.547110e-01 0.184
R-HSA-448424 Interleukin-17 signaling 6.547110e-01 0.184
R-HSA-9764560 Regulation of CDH1 Gene Transcription 6.547110e-01 0.184
R-HSA-69202 Cyclin E associated events during G1/S transition 6.547110e-01 0.184
R-HSA-195253 Degradation of beta-catenin by the destruction complex 6.547110e-01 0.184
R-HSA-9824439 Bacterial Infection Pathways 6.593947e-01 0.181
R-HSA-427413 NoRC negatively regulates rRNA expression 6.593978e-01 0.181
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 6.593978e-01 0.181
R-HSA-453276 Regulation of mitotic cell cycle 6.593978e-01 0.181
R-HSA-5632684 Hedgehog 'on' state 6.593978e-01 0.181
R-HSA-9638482 Metal ion assimilation from the host 6.593978e-01 0.181
R-HSA-975634 Retinoid metabolism and transport 6.593978e-01 0.181
R-HSA-166520 Signaling by NTRKs 6.607873e-01 0.180
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 6.640213e-01 0.178
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 6.640213e-01 0.178
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 6.685823e-01 0.175
R-HSA-4086398 Ca2+ pathway 6.685823e-01 0.175
R-HSA-1266738 Developmental Biology 6.723795e-01 0.172
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 6.734956e-01 0.172
R-HSA-8852135 Protein ubiquitination 6.775203e-01 0.169
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 6.797042e-01 0.168
R-HSA-5689603 UCH proteinases 6.818988e-01 0.166
R-HSA-1980143 Signaling by NOTCH1 6.818988e-01 0.166
R-HSA-168273 Influenza Viral RNA Transcription and Replication 6.827724e-01 0.166
R-HSA-9612973 Autophagy 6.858166e-01 0.164
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 6.862182e-01 0.164
R-HSA-5619084 ABC transporter disorders 6.904792e-01 0.161
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 6.988292e-01 0.156
R-HSA-5654738 Signaling by FGFR2 6.988292e-01 0.156
R-HSA-9833482 PKR-mediated signaling 6.988292e-01 0.156
R-HSA-977225 Amyloid fiber formation 7.029197e-01 0.153
R-HSA-6806667 Metabolism of fat-soluble vitamins 7.029197e-01 0.153
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 7.069549e-01 0.151
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 7.109356e-01 0.148
R-HSA-5687128 MAPK6/MAPK4 signaling 7.187361e-01 0.143
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 7.225574e-01 0.141
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 7.225574e-01 0.141
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 7.263270e-01 0.139
R-HSA-1614635 Sulfur amino acid metabolism 7.263270e-01 0.139
R-HSA-72306 tRNA processing 7.286662e-01 0.137
R-HSA-438064 Post NMDA receptor activation events 7.300457e-01 0.137
R-HSA-156902 Peptide chain elongation 7.337140e-01 0.134
R-HSA-9909648 Regulation of PD-L1(CD274) expression 7.339909e-01 0.134
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 7.392269e-01 0.131
R-HSA-112310 Neurotransmitter release cycle 7.409025e-01 0.130
R-HSA-9734767 Developmental Cell Lineages 7.414760e-01 0.130
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 7.444240e-01 0.128
R-HSA-1912408 Pre-NOTCH Transcription and Translation 7.444240e-01 0.128
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 7.478978e-01 0.126
R-HSA-156842 Eukaryotic Translation Elongation 7.513246e-01 0.124
R-HSA-168249 Innate Immune System 7.516593e-01 0.124
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 7.547051e-01 0.122
R-HSA-9837999 Mitochondrial protein degradation 7.580398e-01 0.120
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 7.613294e-01 0.118
R-HSA-72764 Eukaryotic Translation Termination 7.645744e-01 0.117
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 7.645744e-01 0.117
R-HSA-597592 Post-translational protein modification 7.663330e-01 0.116
R-HSA-71291 Metabolism of amino acids and derivatives 7.690191e-01 0.114
R-HSA-8957275 Post-translational protein phosphorylation 7.740484e-01 0.111
R-HSA-975871 MyD88 cascade initiated on plasma membrane 7.740484e-01 0.111
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 7.740484e-01 0.111
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 7.740484e-01 0.111
R-HSA-190236 Signaling by FGFR 7.740484e-01 0.111
R-HSA-983712 Ion channel transport 7.757621e-01 0.110
R-HSA-70171 Glycolysis 7.801526e-01 0.108
R-HSA-382556 ABC-family proteins mediated transport 7.801526e-01 0.108
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 7.825115e-01 0.107
R-HSA-2408557 Selenocysteine synthesis 7.831428e-01 0.106
R-HSA-1630316 Glycosaminoglycan metabolism 7.847216e-01 0.105
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 7.860926e-01 0.105
R-HSA-1483255 PI Metabolism 7.860926e-01 0.105
R-HSA-192823 Viral mRNA Translation 7.890024e-01 0.103
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 7.918728e-01 0.101
R-HSA-5673001 RAF/MAP kinase cascade 7.928891e-01 0.101
R-HSA-5619507 Activation of HOX genes during differentiation 7.947043e-01 0.100
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 7.947043e-01 0.100
R-HSA-9833110 RSV-host interactions 7.947043e-01 0.100
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 7.974975e-01 0.098
R-HSA-389948 Co-inhibition by PD-1 7.996484e-01 0.097
R-HSA-418346 Platelet homeostasis 8.002528e-01 0.097
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 8.029709e-01 0.095
R-HSA-5684996 MAPK1/MAPK3 signaling 8.051941e-01 0.094
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 8.056521e-01 0.094
R-HSA-2672351 Stimuli-sensing channels 8.056521e-01 0.094
R-HSA-376176 Signaling by ROBO receptors 8.057613e-01 0.094
R-HSA-975155 MyD88 dependent cascade initiated on endosome 8.082970e-01 0.092
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 8.109060e-01 0.091
R-HSA-166166 MyD88-independent TLR4 cascade 8.109060e-01 0.091
R-HSA-6803157 Antimicrobial peptides 8.134797e-01 0.090
R-HSA-6805567 Keratinization 8.136547e-01 0.090
R-HSA-2871796 FCERI mediated MAPK activation 8.160186e-01 0.088
R-HSA-1912422 Pre-NOTCH Expression and Processing 8.185230e-01 0.087
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 8.234305e-01 0.084
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 8.249601e-01 0.084
R-HSA-2029485 Role of phospholipids in phagocytosis 8.282059e-01 0.082
R-HSA-4420097 VEGFA-VEGFR2 Pathway 8.282059e-01 0.082
R-HSA-373760 L1CAM interactions 8.305451e-01 0.081
R-HSA-2219528 PI3K/AKT Signaling in Cancer 8.351290e-01 0.078
R-HSA-9759194 Nuclear events mediated by NFE2L2 8.417743e-01 0.075
R-HSA-112315 Transmission across Chemical Synapses 8.470533e-01 0.072
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 8.522625e-01 0.069
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 8.522625e-01 0.069
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 8.522625e-01 0.069
R-HSA-194138 Signaling by VEGF 8.522625e-01 0.069
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 8.542755e-01 0.068
R-HSA-446203 Asparagine N-linked glycosylation 8.546911e-01 0.068
R-HSA-199418 Negative regulation of the PI3K/AKT network 8.620584e-01 0.064
R-HSA-72766 Translation 8.628762e-01 0.064
R-HSA-5683057 MAPK family signaling cascades 8.775045e-01 0.057
R-HSA-5619115 Disorders of transmembrane transporters 8.794489e-01 0.056
R-HSA-9664422 FCGR3A-mediated phagocytosis 8.830103e-01 0.054
R-HSA-9664407 Parasite infection 8.830103e-01 0.054
R-HSA-9664417 Leishmania phagocytosis 8.830103e-01 0.054
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 8.846061e-01 0.053
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 8.899255e-01 0.051
R-HSA-388841 Regulation of T cell activation by CD28 family 8.906882e-01 0.050
R-HSA-392499 Metabolism of proteins 8.943094e-01 0.049
R-HSA-2187338 Visual phototransduction 8.951860e-01 0.048
R-HSA-9758941 Gastrulation 8.980274e-01 0.047
R-HSA-9755511 KEAP1-NFE2L2 pathway 9.007921e-01 0.045
R-HSA-112316 Neuronal System 9.016219e-01 0.045
R-HSA-9609507 Protein localization 9.034822e-01 0.044
R-HSA-9711097 Cellular response to starvation 9.098939e-01 0.041
R-HSA-9824443 Parasitic Infection Pathways 9.170198e-01 0.038
R-HSA-9658195 Leishmania infection 9.170198e-01 0.038
R-HSA-5619102 SLC transporter disorders 9.203852e-01 0.036
R-HSA-9664433 Leishmania parasite growth and survival 9.276965e-01 0.033
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 9.276965e-01 0.033
R-HSA-9640148 Infection with Enterobacteria 9.521744e-01 0.021
R-HSA-1474244 Extracellular matrix organization 9.528692e-01 0.021
R-HSA-388396 GPCR downstream signalling 9.615858e-01 0.017
R-HSA-8951664 Neddylation 9.632038e-01 0.016
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 9.675046e-01 0.014
R-HSA-196854 Metabolism of vitamins and cofactors 9.678457e-01 0.014
R-HSA-416476 G alpha (q) signalling events 9.796942e-01 0.009
R-HSA-9711123 Cellular response to chemical stress 9.807883e-01 0.008
R-HSA-418594 G alpha (i) signalling events 9.808705e-01 0.008
R-HSA-372790 Signaling by GPCR 9.813413e-01 0.008
R-HSA-1483257 Phospholipid metabolism 9.867855e-01 0.006
R-HSA-382551 Transport of small molecules 9.981133e-01 0.001
R-HSA-9709957 Sensory Perception 1.000000e+00 0.000
R-HSA-556833 Metabolism of lipids 1.000000e+00 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
FAM20CFAM20C 0.831 0.433 2 0.876
COTCOT 0.830 0.085 2 0.743
PIM3PIM3 0.825 0.123 -3 0.901
PIM1PIM1 0.823 0.168 -3 0.874
RSK2RSK2 0.823 0.158 -3 0.871
CAMK1BCAMK1B 0.821 0.127 -3 0.904
PRKD2PRKD2 0.820 0.158 -3 0.875
PRKD1PRKD1 0.820 0.131 -3 0.887
ATMATM 0.819 0.263 1 0.879
PKN3PKN3 0.819 0.090 -3 0.886
P90RSKP90RSK 0.818 0.143 -3 0.867
SKMLCKSKMLCK 0.818 0.176 -2 0.836
ATRATR 0.818 0.190 1 0.887
CAMK2BCAMK2B 0.818 0.203 2 0.758
CDKL1CDKL1 0.818 0.128 -3 0.872
CLK3CLK3 0.818 0.108 1 0.760
CAMLCKCAMLCK 0.817 0.152 -2 0.839
CDC7CDC7 0.816 0.028 1 0.859
MAPKAPK3MAPKAPK3 0.816 0.140 -3 0.874
DAPK2DAPK2 0.815 0.168 -3 0.894
TGFBR2TGFBR2 0.815 0.080 -2 0.827
NDR1NDR1 0.815 0.071 -3 0.901
RIPK3RIPK3 0.815 0.098 3 0.773
DSTYKDSTYK 0.815 0.058 2 0.761
NDR2NDR2 0.814 0.050 -3 0.897
RSK3RSK3 0.814 0.127 -3 0.871
CAMK2DCAMK2D 0.814 0.141 -3 0.879
P70S6KBP70S6KB 0.814 0.118 -3 0.881
MAPKAPK2MAPKAPK2 0.814 0.157 -3 0.856
LATS2LATS2 0.813 0.071 -5 0.680
PRKD3PRKD3 0.813 0.154 -3 0.853
PKCDPKCD 0.813 0.066 2 0.645
CDKL5CDKL5 0.813 0.113 -3 0.868
PRPKPRPK 0.813 -0.062 -1 0.721
CAMK2GCAMK2G 0.812 0.040 2 0.723
BMPR2BMPR2 0.811 0.030 -2 0.857
WNK1WNK1 0.811 0.040 -2 0.817
NLKNLK 0.811 0.037 1 0.712
NIKNIK 0.810 0.045 -3 0.896
TSSK2TSSK2 0.810 0.071 -5 0.762
CAMK4CAMK4 0.809 0.084 -3 0.882
MOSMOS 0.809 -0.016 1 0.841
NUAK2NUAK2 0.809 0.055 -3 0.900
MYLK4MYLK4 0.808 0.158 -2 0.791
PKN2PKN2 0.808 0.045 -3 0.881
RSK4RSK4 0.808 0.136 -3 0.852
RAF1RAF1 0.808 -0.065 1 0.794
PKACGPKACG 0.808 0.087 -2 0.779
TSSK1TSSK1 0.808 0.057 -3 0.912
MSK1MSK1 0.808 0.150 -3 0.847
MELKMELK 0.807 0.093 -3 0.884
PIM2PIM2 0.807 0.151 -3 0.852
GCN2GCN2 0.807 -0.089 2 0.647
AMPKA1AMPKA1 0.806 0.025 -3 0.901
LATS1LATS1 0.806 0.120 -3 0.904
WNK3WNK3 0.806 -0.010 1 0.770
AURBAURB 0.806 0.101 -2 0.699
ICKICK 0.806 0.070 -3 0.892
MSK2MSK2 0.806 0.113 -3 0.837
ERK5ERK5 0.805 0.042 1 0.729
ULK2ULK2 0.805 -0.126 2 0.641
SMG1SMG1 0.805 0.297 1 0.863
NUAK1NUAK1 0.805 0.071 -3 0.891
BMPR1BBMPR1B 0.805 0.127 1 0.802
TBK1TBK1 0.804 -0.065 1 0.676
CAMK2ACAMK2A 0.804 0.113 2 0.711
PDHK4PDHK4 0.804 -0.113 1 0.784
MNK2MNK2 0.804 0.067 -2 0.791
SRPK1SRPK1 0.804 0.099 -3 0.842
MST4MST4 0.804 -0.007 2 0.682
PAK1PAK1 0.803 0.059 -2 0.786
PAK3PAK3 0.803 0.055 -2 0.786
AURCAURC 0.803 0.076 -2 0.699
AMPKA2AMPKA2 0.802 0.045 -3 0.893
ALK2ALK2 0.802 0.169 -2 0.842
MLK1MLK1 0.802 -0.058 2 0.668
TGFBR1TGFBR1 0.802 0.113 -2 0.837
PKG2PKG2 0.802 0.109 -2 0.721
DNAPKDNAPK 0.802 0.209 1 0.787
CHK1CHK1 0.802 0.083 -3 0.907
IKKBIKKB 0.802 -0.059 -2 0.709
PKACBPKACB 0.802 0.122 -2 0.723
SRPK2SRPK2 0.801 0.115 -3 0.796
NIM1NIM1 0.801 0.008 3 0.737
IRE2IRE2 0.801 0.001 2 0.620
CLK1CLK1 0.801 0.115 -3 0.854
MARK4MARK4 0.801 -0.014 4 0.756
ALK4ALK4 0.800 0.077 -2 0.847
NEK7NEK7 0.800 -0.093 -3 0.786
HUNKHUNK 0.800 -0.089 2 0.631
SGK3SGK3 0.800 0.104 -3 0.854
CAMK1DCAMK1D 0.800 0.157 -3 0.825
SMMLCKSMMLCK 0.800 0.153 -3 0.879
AKT2AKT2 0.799 0.131 -3 0.810
CLK4CLK4 0.799 0.108 -3 0.861
DAPK3DAPK3 0.799 0.189 -3 0.880
PKCBPKCB 0.799 0.023 2 0.597
GRK6GRK6 0.799 -0.005 1 0.815
RIPK1RIPK1 0.798 -0.035 1 0.771
MNK1MNK1 0.797 0.057 -2 0.804
NEK9NEK9 0.797 -0.085 2 0.668
PAK2PAK2 0.797 0.050 -2 0.772
IKKEIKKE 0.796 -0.095 1 0.669
PAK6PAK6 0.796 0.074 -2 0.707
ANKRD3ANKRD3 0.796 -0.064 1 0.812
PKRPKR 0.796 0.004 1 0.794
PLK1PLK1 0.796 -0.021 -2 0.810
CAMK1GCAMK1G 0.796 0.081 -3 0.855
PDHK1PDHK1 0.795 -0.195 1 0.774
PKCHPKCH 0.795 0.015 2 0.583
PRKXPRKX 0.795 0.137 -3 0.804
ACVR2AACVR2A 0.795 0.070 -2 0.806
SRPK3SRPK3 0.795 0.089 -3 0.817
PHKG1PHKG1 0.795 0.022 -3 0.886
BMPR1ABMPR1A 0.795 0.134 1 0.793
PKACAPKACA 0.795 0.131 -2 0.681
GRK1GRK1 0.794 0.021 -2 0.780
MLK2MLK2 0.794 -0.094 2 0.673
DCAMKL1DCAMKL1 0.794 0.072 -3 0.883
ULK1ULK1 0.794 -0.140 -3 0.772
AURAAURA 0.794 0.080 -2 0.674
MTORMTOR 0.794 -0.186 1 0.696
MAPKAPK5MAPKAPK5 0.794 0.100 -3 0.815
AKT1AKT1 0.794 0.130 -3 0.824
NEK6NEK6 0.794 -0.113 -2 0.818
ACVR2BACVR2B 0.794 0.080 -2 0.818
SIKSIK 0.794 0.053 -3 0.857
DLKDLK 0.793 -0.116 1 0.787
PKCGPKCG 0.793 -0.007 2 0.587
IRE1IRE1 0.793 -0.077 1 0.751
PKCAPKCA 0.793 0.001 2 0.586
P70S6KP70S6K 0.792 0.107 -3 0.820
QIKQIK 0.792 -0.019 -3 0.864
CLK2CLK2 0.792 0.121 -3 0.862
MASTLMASTL 0.792 -0.163 -2 0.773
CHAK2CHAK2 0.791 -0.102 -1 0.697
GRK5GRK5 0.791 -0.146 -3 0.801
MLK3MLK3 0.790 -0.047 2 0.605
DCAMKL2DCAMKL2 0.790 0.057 -3 0.897
MLK4MLK4 0.790 -0.055 2 0.605
IKKAIKKA 0.790 -0.055 -2 0.697
QSKQSK 0.789 0.003 4 0.731
PLK3PLK3 0.789 -0.000 2 0.658
CAMK1ACAMK1A 0.789 0.144 -3 0.798
DAPK1DAPK1 0.789 0.148 -3 0.858
BRSK1BRSK1 0.788 0.019 -3 0.882
MEK1MEK1 0.788 -0.080 2 0.686
HIPK4HIPK4 0.788 -0.014 1 0.679
PKCZPKCZ 0.787 -0.043 2 0.623
SNRKSNRK 0.787 -0.032 2 0.548
GRK4GRK4 0.787 -0.082 -2 0.806
IRAK4IRAK4 0.787 -0.028 1 0.769
PKCTPKCT 0.787 0.023 2 0.594
TTBK2TTBK2 0.787 -0.126 2 0.549
MARK2MARK2 0.787 -0.000 4 0.647
DRAK1DRAK1 0.786 -0.021 1 0.748
BRAFBRAF 0.786 -0.027 -4 0.748
NEK2NEK2 0.786 -0.094 2 0.637
BCKDKBCKDK 0.786 -0.148 -1 0.652
CHK2CHK2 0.786 0.138 -3 0.775
SSTKSSTK 0.786 0.012 4 0.727
CHAK1CHAK1 0.785 -0.094 2 0.588
PHKG2PHKG2 0.785 0.033 -3 0.871
MRCKBMRCKB 0.784 0.135 -3 0.842
VRK2VRK2 0.784 -0.164 1 0.807
MRCKAMRCKA 0.784 0.128 -3 0.859
MARK1MARK1 0.784 -0.006 4 0.711
BRSK2BRSK2 0.783 -0.034 -3 0.882
HRIHRI 0.783 -0.080 -2 0.830
WNK4WNK4 0.783 -0.054 -2 0.787
PERKPERK 0.782 -0.074 -2 0.823
IRAK1IRAK1 0.781 -0.044 -1 0.682
AKT3AKT3 0.781 0.121 -3 0.764
PLK4PLK4 0.781 -0.086 2 0.503
SGK1SGK1 0.781 0.132 -3 0.753
PKN1PKN1 0.781 0.077 -3 0.829
NEK5NEK5 0.781 -0.050 1 0.803
DYRK2DYRK2 0.780 -0.010 1 0.568
ROCK2ROCK2 0.780 0.122 -3 0.871
DYRK1ADYRK1A 0.780 0.039 1 0.607
YSK4YSK4 0.780 -0.145 1 0.716
MARK3MARK3 0.780 -0.032 4 0.680
PAK5PAK5 0.779 0.051 -2 0.664
DMPK1DMPK1 0.779 0.148 -3 0.861
CDK7CDK7 0.778 -0.061 1 0.547
TLK2TLK2 0.778 -0.077 1 0.797
PKCIPKCI 0.778 -0.007 2 0.593
P38AP38A 0.778 -0.027 1 0.579
HIPK1HIPK1 0.777 0.015 1 0.579
CDK8CDK8 0.777 -0.070 1 0.539
PAK4PAK4 0.777 0.053 -2 0.675
GRK7GRK7 0.777 -0.035 1 0.733
PKCEPKCE 0.777 0.040 2 0.569
PKG1PKG1 0.776 0.112 -2 0.647
CDK5CDK5 0.776 -0.056 1 0.570
PASKPASK 0.775 0.001 -3 0.885
MEKK2MEKK2 0.775 -0.105 2 0.660
MEKK1MEKK1 0.775 -0.138 1 0.765
TLK1TLK1 0.775 -0.062 -2 0.832
GRK2GRK2 0.775 -0.056 -2 0.706
ZAKZAK 0.775 -0.144 1 0.736
CDK14CDK14 0.774 -0.003 1 0.509
MEK5MEK5 0.774 -0.183 2 0.669
JNK2JNK2 0.774 -0.031 1 0.481
MEKK3MEKK3 0.774 -0.135 1 0.744
CDK18CDK18 0.773 -0.038 1 0.470
HIPK3HIPK3 0.773 0.000 1 0.570
ERK2ERK2 0.773 -0.052 1 0.534
MST3MST3 0.772 -0.072 2 0.646
SBKSBK 0.772 0.124 -3 0.731
CDK2CDK2 0.772 -0.058 1 0.588
DYRK3DYRK3 0.772 0.048 1 0.583
ROCK1ROCK1 0.772 0.121 -3 0.853
KISKIS 0.771 -0.064 1 0.568
NEK8NEK8 0.771 -0.095 2 0.650
TAO2TAO2 0.771 -0.064 2 0.686
JNK3JNK3 0.770 -0.058 1 0.522
GAKGAK 0.770 -0.029 1 0.780
CRIKCRIK 0.770 0.136 -3 0.827
CDK19CDK19 0.770 -0.073 1 0.498
EEF2KEEF2K 0.769 -0.040 3 0.751
P38BP38B 0.769 -0.036 1 0.512
CAMKK1CAMKK1 0.769 -0.108 -2 0.722
TTBK1TTBK1 0.768 -0.089 2 0.481
CDK16CDK16 0.768 -0.022 1 0.434
BUB1BUB1 0.767 0.056 -5 0.738
NEK4NEK4 0.767 -0.080 1 0.744
PINK1PINK1 0.767 -0.142 1 0.727
TAO3TAO3 0.767 -0.114 1 0.730
ERK1ERK1 0.767 -0.056 1 0.493
DYRK4DYRK4 0.767 0.003 1 0.488
MPSK1MPSK1 0.767 -0.064 1 0.704
HIPK2HIPK2 0.767 -0.014 1 0.467
CDK17CDK17 0.767 -0.055 1 0.416
TTKTTK 0.766 0.078 -2 0.829
PDK1PDK1 0.766 -0.054 1 0.732
MEKK6MEKK6 0.766 -0.096 1 0.753
ERK7ERK7 0.766 -0.022 2 0.442
CDK1CDK1 0.765 -0.073 1 0.501
PLK2PLK2 0.765 0.011 -3 0.796
MAKMAK 0.765 0.067 -2 0.697
DYRK1BDYRK1B 0.765 -0.011 1 0.513
CDK13CDK13 0.765 -0.095 1 0.513
LOKLOK 0.764 -0.047 -2 0.755
NEK1NEK1 0.764 -0.063 1 0.759
TAK1TAK1 0.764 -0.036 1 0.793
TNIKTNIK 0.764 -0.048 3 0.765
MOKMOK 0.764 0.058 1 0.615
CAMKK2CAMKK2 0.763 -0.136 -2 0.720
HGKHGK 0.763 -0.079 3 0.772
NEK11NEK11 0.763 -0.173 1 0.730
VRK1VRK1 0.762 -0.088 2 0.681
CDK10CDK10 0.762 -0.032 1 0.496
MINKMINK 0.762 -0.080 1 0.732
RIPK2RIPK2 0.761 -0.093 1 0.692
MST2MST2 0.761 -0.119 1 0.759
CK2A2CK2A2 0.761 0.005 1 0.706
CDK9CDK9 0.760 -0.099 1 0.519
CDK3CDK3 0.760 -0.039 1 0.438
P38GP38G 0.760 -0.070 1 0.408
GCKGCK 0.760 -0.101 1 0.732
MAP3K15MAP3K15 0.759 -0.135 1 0.711
GSK3BGSK3B 0.759 -0.051 4 0.407
CDK12CDK12 0.759 -0.091 1 0.483
LKB1LKB1 0.759 -0.147 -3 0.786
LRRK2LRRK2 0.758 -0.140 2 0.671
PRP4PRP4 0.758 -0.097 -3 0.664
MEK2MEK2 0.757 -0.122 2 0.657
GRK3GRK3 0.757 -0.067 -2 0.671
BIKEBIKE 0.757 0.041 1 0.656
HPK1HPK1 0.756 -0.073 1 0.710
CK1ECK1E 0.755 -0.087 -3 0.449
KHS1KHS1 0.755 -0.067 1 0.710
MST1MST1 0.755 -0.135 1 0.735
KHS2KHS2 0.754 -0.042 1 0.719
PBKPBK 0.753 -0.042 1 0.712
CDK4CDK4 0.753 -0.049 1 0.470
YSK1YSK1 0.753 -0.114 2 0.639
SLKSLK 0.752 -0.102 -2 0.697
P38DP38D 0.751 -0.054 1 0.452
CDK6CDK6 0.751 -0.063 1 0.487
STK33STK33 0.751 -0.139 2 0.476
GSK3AGSK3A 0.750 -0.065 4 0.424
NEK3NEK3 0.749 -0.122 1 0.705
CK2A1CK2A1 0.749 -0.012 1 0.681
ALPHAK3ALPHAK3 0.748 0.021 -1 0.622
HASPINHASPIN 0.747 -0.036 -1 0.584
CK1DCK1D 0.747 -0.078 -3 0.391
CK1A2CK1A2 0.744 -0.092 -3 0.399
JNK1JNK1 0.744 -0.073 1 0.470
AAK1AAK1 0.743 0.053 1 0.551
OSR1OSR1 0.742 -0.117 2 0.642
CK1G1CK1G1 0.741 -0.119 -3 0.455
MYO3BMYO3B 0.741 -0.084 2 0.650
MYO3AMYO3A 0.740 -0.084 1 0.714
ASK1ASK1 0.739 -0.133 1 0.698
TAO1TAO1 0.736 -0.108 1 0.659
YANK3YANK3 0.734 -0.075 2 0.317
PDHK3_TYRPDHK3_TYR 0.733 0.032 4 0.867
TNK2TNK2 0.733 0.210 3 0.806
EPHA6EPHA6 0.732 0.121 -1 0.691
TYRO3TYRO3 0.731 0.138 3 0.772
YES1YES1 0.730 0.144 -1 0.761
EPHB4EPHB4 0.729 0.140 -1 0.717
TECTEC 0.729 0.194 -1 0.742
SRMSSRMS 0.729 0.209 1 0.853
STLK3STLK3 0.729 -0.136 1 0.701
AXLAXL 0.728 0.195 3 0.794
BLKBLK 0.727 0.183 -1 0.729
MERTKMERTK 0.727 0.215 3 0.768
TXKTXK 0.727 0.153 1 0.828
ROS1ROS1 0.725 0.057 3 0.767
ABL2ABL2 0.725 0.102 -1 0.716
TESK1_TYRTESK1_TYR 0.725 -0.097 3 0.778
FERFER 0.723 0.095 1 0.872
HCKHCK 0.723 0.138 -1 0.741
RETRET 0.723 0.011 1 0.751
LCKLCK 0.723 0.136 -1 0.721
INSRRINSRR 0.723 0.079 3 0.757
EPHB1EPHB1 0.722 0.128 1 0.852
PDHK4_TYRPDHK4_TYR 0.722 -0.049 2 0.732
PINK1_TYRPINK1_TYR 0.721 -0.121 1 0.776
ITKITK 0.721 0.083 -1 0.737
BMXBMX 0.721 0.113 -1 0.688
MAP2K6_TYRMAP2K6_TYR 0.721 -0.075 -1 0.716
EPHA1EPHA1 0.721 0.182 3 0.789
LIMK2_TYRLIMK2_TYR 0.721 -0.050 -3 0.882
EPHB2EPHB2 0.721 0.130 -1 0.706
LTKLTK 0.720 0.111 3 0.750
DDR1DDR1 0.720 0.025 4 0.776
MST1RMST1R 0.720 0.024 3 0.794
MAP2K4_TYRMAP2K4_TYR 0.720 -0.131 -1 0.731
TYK2TYK2 0.720 -0.036 1 0.754
MAP2K7_TYRMAP2K7_TYR 0.720 -0.195 2 0.706
CSF1RCSF1R 0.719 0.046 3 0.790
PDGFRBPDGFRB 0.719 0.026 3 0.800
EPHB3EPHB3 0.719 0.116 -1 0.709
EPHA4EPHA4 0.718 0.077 2 0.653
TEKTEK 0.718 0.094 3 0.749
PKMYT1_TYRPKMYT1_TYR 0.718 -0.176 3 0.773
BTKBTK 0.717 0.131 -1 0.759
EPHA7EPHA7 0.717 0.131 2 0.651
ABL1ABL1 0.717 0.052 -1 0.719
BMPR2_TYRBMPR2_TYR 0.717 -0.087 -1 0.681
DDR2DDR2 0.716 0.107 3 0.781
ALKALK 0.716 0.058 3 0.744
FLT3FLT3 0.715 0.024 3 0.777
PDHK1_TYRPDHK1_TYR 0.715 -0.120 -1 0.722
FGFR2FGFR2 0.715 0.033 3 0.790
JAK2JAK2 0.715 -0.038 1 0.746
TNK1TNK1 0.714 -0.020 3 0.742
EPHA5EPHA5 0.714 0.141 2 0.661
PTK2BPTK2B 0.714 0.103 -1 0.738
LIMK1_TYRLIMK1_TYR 0.713 -0.170 2 0.699
FYNFYN 0.712 0.087 -1 0.684
FGRFGR 0.712 -0.041 1 0.824
JAK3JAK3 0.712 -0.059 1 0.742
LYNLYN 0.711 0.110 3 0.723
KDRKDR 0.711 0.003 3 0.787
JAK1JAK1 0.710 0.009 1 0.688
EPHA3EPHA3 0.710 0.049 2 0.628
FRKFRK 0.709 0.082 -1 0.766
KITKIT 0.709 -0.012 3 0.790
FGFR1FGFR1 0.709 -0.016 3 0.783
PDGFRAPDGFRA 0.708 -0.035 3 0.797
NTRK1NTRK1 0.707 0.005 -1 0.678
NTRK2NTRK2 0.706 0.009 3 0.774
METMET 0.705 -0.023 3 0.785
FGFR3FGFR3 0.703 0.003 3 0.779
NEK10_TYRNEK10_TYR 0.703 -0.089 1 0.605
INSRINSR 0.703 -0.022 3 0.729
TNNI3K_TYRTNNI3K_TYR 0.702 -0.107 1 0.769
EPHA8EPHA8 0.702 0.042 -1 0.659
YANK2YANK2 0.701 -0.100 2 0.348
SRCSRC 0.700 0.029 -1 0.699
PTK6PTK6 0.700 -0.082 -1 0.662
WEE1_TYRWEE1_TYR 0.700 -0.070 -1 0.665
FLT4FLT4 0.698 -0.066 3 0.752
NTRK3NTRK3 0.698 -0.016 -1 0.632
ERBB2ERBB2 0.698 -0.062 1 0.717
CK1ACK1A 0.698 -0.124 -3 0.303
MATKMATK 0.696 -0.054 -1 0.629
CK1G3CK1G3 0.694 -0.099 -3 0.256
EPHA2EPHA2 0.693 0.046 -1 0.628
EGFREGFR 0.693 -0.018 1 0.637
CSKCSK 0.691 -0.057 2 0.645
FGFR4FGFR4 0.689 -0.011 -1 0.638
FLT1FLT1 0.689 -0.129 -1 0.633
IGF1RIGF1R 0.689 -0.039 3 0.675
PTK2PTK2 0.689 -0.015 -1 0.576
FESFES 0.683 0.002 -1 0.648
ERBB4ERBB4 0.683 -0.008 1 0.671
MUSKMUSK 0.682 -0.091 1 0.626
SYKSYK 0.682 -0.024 -1 0.576
CK1G2CK1G2 0.670 -0.108 -3 0.361
ZAP70ZAP70 0.652 -0.093 -1 0.524