Motif 682 (n=201)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A0J9YX86 | GOLGA8Q | S90 | ochoa | Golgin A8 family member Q | None |
A0JNW5 | BLTP3B | S774 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
A6NC98 | CCDC88B | S1253 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
A6NMD2 | GOLGA8J | S260 | ochoa | Golgin subfamily A member 8J | None |
E9PMD0 | None | S240 | ochoa | Uncharacterized protein | None |
H3BQL2 | GOLGA8T | S260 | ochoa | Golgin subfamily A member 8T | None |
H3BSY2 | GOLGA8M | S260 | ochoa | Golgin subfamily A member 8M | None |
I6L899 | GOLGA8R | S90 | ochoa | Golgin subfamily A member 8R | None |
I6L899 | GOLGA8R | S260 | ochoa | Golgin subfamily A member 8R | None |
O15344 | MID1 | S213 | ochoa | E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) | Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}. |
O43264 | ZW10 | S103 | ochoa | Centromere/kinetochore protein zw10 homolog | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000305}. |
O43298 | ZBTB43 | S200 | ochoa | Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x) | May be involved in transcriptional regulation. |
O43597 | SPRY2 | S167 | psp | Protein sprouty homolog 2 (Spry-2) | Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561). {ECO:0000250|UniProtKB:Q9QXV8, ECO:0000269|PubMed:17974561}. |
O43747 | AP1G1 | S369 | ochoa | AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000269|PubMed:34102099}. |
O60216 | RAD21 | S185 | ochoa|psp | Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] | [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:Q61550, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:25575569, ECO:0000305|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}. |
O75116 | ROCK2 | T979 | ochoa | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
O75154 | RAB11FIP3 | S538 | ochoa|psp | Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148) | Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867). {ECO:0000250|UniProtKB:Q8CHD8, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:17628206, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19327867, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26258637, ECO:0000269|PubMed:31204173}. |
O75369 | FLNB | S81 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75469 | NR1I2 | S200 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
O75643 | SNRNP200 | S756 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
O75665 | OFD1 | S899 | ochoa|psp | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
O75955 | FLOT1 | Y348 | ochoa | Flotillin-1 | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. |
O94964 | MTCL2 | S931 | ochoa | Microtubule cross-linking factor 2 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)] | Microtubule-associated factor that enables integration of the centrosomal and Golgi-associated microtubules on the Golgi membrane, supporting directional migration. Preferentially acts on the perinuclear microtubules accumulated around the Golgi. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain (By similarity). Required for faithful chromosome segregation during mitosis (PubMed:33587225). Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner (By similarity). {ECO:0000250|UniProtKB:E1U8D0, ECO:0000269|PubMed:33587225}. |
O95235 | KIF20A | S683 | ochoa|psp | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
O95613 | PCNT | S682 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
P02545 | LMNA | S303 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
P02545 | LMNA | S307 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
P07332 | FES | S117 | ochoa | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}. |
P08670 | VIM | T327 | ochoa|psp | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
P0CJ92 | GOLGA8H | S260 | ochoa | Golgin subfamily A member 8H | None |
P10275 | AR | S792 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
P10645 | CHGA | S438 | ochoa | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
P10809 | HSPD1 | S398 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
P11055 | MYH3 | S1479 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
P11137 | MAP2 | S1134 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
P11532 | DMD | S3500 | ochoa | Dystrophin | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}. |
P12882 | MYH1 | T997 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
P12882 | MYH1 | T1278 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
P12882 | MYH1 | S1482 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
P12883 | MYH7 | S1102 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P12883 | MYH7 | T1274 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P12883 | MYH7 | S1478 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P12956 | XRCC6 | S477 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
P13533 | MYH6 | S1480 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
P13535 | MYH8 | T1277 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
P13535 | MYH8 | S1481 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
P14316 | IRF2 | S148 | ochoa | Interferon regulatory factor 2 (IRF-2) | Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}. |
P15924 | DSP | S1658 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
P16885 | PLCG2 | S1236 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:0000269|PubMed:23000145}. |
P18206 | VCL | S357 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
P19338 | NCL | S482 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
P20700 | LMNB1 | S304 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
P21333 | FLNA | S108 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P22415 | USF1 | S262 | psp | Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1) | Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. |
P30101 | PDIA3 | S474 | ochoa | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}. |
P31689 | DNAJA1 | S112 | ochoa | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}. |
P31947 | SFN | S209 | ochoa | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
P35749 | MYH11 | S998 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
P39748 | FEN1 | S210 | ochoa | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
P42285 | MTREX | S687 | ochoa | Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase) | Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension (PubMed:27871484, PubMed:29844170, PubMed:29906447). Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) (PubMed:21855801, PubMed:27871484, PubMed:29844170). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484, PubMed:29844170). PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand (PubMed:29844170). Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (PubMed:29906447). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:29107693, ECO:0000269|PubMed:29844170, ECO:0000269|PubMed:29902117, ECO:0000269|PubMed:29906447}. |
P46060 | RANGAP1 | S24 | ochoa | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
P46939 | UTRN | S784 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
P48552 | NRIP1 | S102 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
P49908 | SELENOP | S266 | ochoa | Selenoprotein P (SeP) | Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis. |
P52630 | STAT2 | S287 | psp | Signal transducer and activator of transcription 2 (p113) | Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}. |
P52630 | STAT2 | S734 | psp | Signal transducer and activator of transcription 2 (p113) | Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}. |
P52732 | KIF11 | T458 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
P55198 | MLLT6 | T744 | ochoa | Protein AF-17 (ALL1-fused gene from chromosome 17 protein) | None |
P60228 | EIF3E | S412 | ochoa | Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924). {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMed:17468741, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
P61978 | HNRNPK | S127 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
P62258 | YWHAE | S210 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
P63104 | YWHAZ | S207 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
P78345 | RPP38 | S226 | ochoa | Ribonuclease P protein subunit p38 (RNaseP protein p38) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}. |
P83916 | CBX1 | S129 | ochoa | Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000250|UniProtKB:P83917}. |
Q00987 | MDM2 | S262 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
Q01658 | DR1 | S105 | ochoa | Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}. |
Q02818 | NUCB1 | S369 | ochoa | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
Q03252 | LMNB2 | S318 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
Q07912 | TNK2 | S529 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
Q08209 | PPP3CA | S438 | ochoa | Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118). Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (PubMed:30718414). Negatively regulates SLC9A1 activity (PubMed:31375679). {ECO:0000250|UniProtKB:P48452, ECO:0000250|UniProtKB:P63328, ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:30254215, ECO:0000269|PubMed:30611118, ECO:0000269|PubMed:30718414, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:33691586}. |
Q08378 | GOLGA3 | S467 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
Q0ZGT2 | NEXN | S442 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
Q13136 | PPFIA1 | S277 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
Q13136 | PPFIA1 | S448 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
Q13185 | CBX3 | S133 | ochoa | Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}. |
Q13200 | PSMD2 | S46 | ochoa | 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. |
Q13416 | ORC2 | S284 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
Q13506 | NAB1 | S356 | ochoa | NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. {ECO:0000250}. |
Q13535 | ATR | S1333 | psp | Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) | Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:27723717, PubMed:27723720, PubMed:30139873, PubMed:33848395, PubMed:37788673, PubMed:37832547, PubMed:9427750, PubMed:9636169). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:23273981, PubMed:27723717, PubMed:27723720, PubMed:33848395, PubMed:9427750, PubMed:9636169). Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed:11418864, PubMed:11865061, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:9925639). Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism (PubMed:11673449). Required for FANCD2 ubiquitination (PubMed:15314022). Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (PubMed:12526805). Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2 (PubMed:30139873). Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress (PubMed:25083873, PubMed:37788673, PubMed:37832547). Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 (PubMed:25083873). Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly (PubMed:37832547). Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture (PubMed:37788673). The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity (PubMed:37788673). Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). {ECO:0000250|UniProtKB:Q9JKK8, ECO:0000269|PubMed:10597277, ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164, ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805, ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973, ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:25083873, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:33848395, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547, ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169, ECO:0000269|PubMed:9925639}. |
Q13568 | IRF5 | S437 | psp | Interferon regulatory factor 5 (IRF-5) | Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}. |
Q14191 | WRN | S258 | ochoa | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
Q14667 | BLTP2 | S1846 | ochoa | Bridge-like lipid transfer protein family member 2 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) (Protein hobbit homolog) | Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution. {ECO:0000250|UniProtKB:Q9VZS7}. |
Q14684 | RRP1B | S579 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
Q14687 | GSE1 | S970 | ochoa | Genetic suppressor element 1 | None |
Q14789 | GOLGB1 | S491 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
Q14789 | GOLGB1 | S1753 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
Q14980 | NUMA1 | T1534 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
Q15046 | KARS1 | S207 | psp | Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:18029264, PubMed:18272479, PubMed:9278442). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:14975237, PubMed:19524539, PubMed:23159739, PubMed:5338216). {ECO:0000269|PubMed:14975237, ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:18029264, ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:28887846, ECO:0000269|PubMed:5338216, ECO:0000269|PubMed:9278442}.; FUNCTION: (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15220430}. |
Q15075 | EEA1 | S354 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
Q15276 | RABEP1 | S362 | ochoa | Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) | Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}. |
Q15678 | PTPN14 | S463 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
Q16204 | CCDC6 | T60 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
Q16822 | PCK2 | S34 | ochoa | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2) | Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:28955899). Can play an active role in glyceroneogenesis and gluconeogenesis (PubMed:28955899). {ECO:0000269|PubMed:28955899}. |
Q2KHM9 | KIAA0753 | S670 | ochoa | Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) | Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}. |
Q2PPJ7 | RALGAPA2 | S1350 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
Q5H943 | CT83 | S85 | ochoa | Kita-kyushu lung cancer antigen 1 (KK-LC-1) (Cancer/testis antigen 83) | None |
Q5JR59 | MTUS2 | S1302 | ochoa | Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) | Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. {ECO:0000269|PubMed:19543227}. |
Q5JTW2 | CEP78 | S453 | ochoa | Centrosomal protein of 78 kDa (Cep78) | Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis (PubMed:27246242, PubMed:27588451, PubMed:28242748, PubMed:34259627). Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). Involved in cilium biogenesis and controls cilium length (PubMed:27588451). Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins (PubMed:28242748, PubMed:34259627). Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (By similarity). {ECO:0000250|UniProtKB:Q6IRU7, ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27588451, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}. |
Q5M775 | SPECC1 | S437 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
Q5TZA2 | CROCC | S1900 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
Q5VST9 | OBSCN | S2964 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
Q674X7 | KAZN | S20 | ochoa | Kazrin | Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}. |
Q6P0N0 | MIS18BP1 | T218 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
Q6UWE0 | LRSAM1 | S290 | ochoa | E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}. |
Q6UWE0 | LRSAM1 | S494 | ochoa | E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}. |
Q6ZU80 | CEP128 | S797 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
Q6ZVD8 | PHLPP2 | S307 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
Q71DI3 | H3C15 | S87 | ochoa | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Q76FK4 | NOL8 | S421 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
Q7L590 | MCM10 | S26 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
Q7RTP6 | MICAL3 | S1586 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
Q86SQ0 | PHLDB2 | S719 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
Q86U44 | METTL3 | S243 | ochoa | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
Q86YT6 | MIB1 | S416 | ochoa | E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.; FUNCTION: (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection. {ECO:0000269|PubMed:31851912}. |
Q8IX03 | WWC1 | T1006 | psp | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
Q8IYF3 | TEX11 | S178 | ochoa | Testis-expressed protein 11 (Protein ZIP4 homolog) (ZIP4H) | Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. {ECO:0000250|UniProtKB:Q14AT2}. |
Q8IYI6 | EXOC8 | S35 | ochoa | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
Q8N4S0 | CCDC82 | S131 | ochoa | Coiled-coil domain-containing protein 82 | None |
Q8N4S0 | CCDC82 | S154 | ochoa | Coiled-coil domain-containing protein 82 | None |
Q8N680 | ZBTB2 | S178 | ochoa | Zinc finger and BTB domain-containing protein 2 | May be involved in transcriptional regulation. |
Q8ND76 | CCNY | S288 | psp | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
Q8TB45 | DEPTOR | S168 | psp | DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}. |
Q8TBA6 | GOLGA5 | S465 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
Q8TBA6 | GOLGA5 | S585 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
Q8TCU6 | PREX1 | S605 | psp | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
Q8TDX6 | CSGALNACT1 | S90 | ochoa | Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CsGalNAcT-1) (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1) (Beta4GalNAcT-1) | Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758, PubMed:31705726). Moreover, is involved in the metabolism of aggrecan (By similarity). {ECO:0000250|UniProtKB:Q8BJQ9, ECO:0000269|PubMed:11788602, ECO:0000269|PubMed:12163485, ECO:0000269|PubMed:12446672, ECO:0000269|PubMed:17145758, ECO:0000269|PubMed:21160489, ECO:0000269|PubMed:27599773, ECO:0000269|PubMed:31705726}. |
Q8WW22 | DNAJA4 | S113 | ochoa | DnaJ homolog subfamily A member 4 | None |
Q92734 | TFG | S99 | ochoa | Protein TFG (TRK-fused gene protein) | Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}. |
Q92783 | STAM | S191 | ochoa | Signal transducing adapter molecule 1 (STAM-1) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.; FUNCTION: (Microbial infection) Plays an important role in Dengue virus entry. {ECO:0000269|PubMed:29742433}. |
Q96JI7 | SPG11 | S1829 | ochoa | Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) | May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. {ECO:0000269|PubMed:24794856}. |
Q96JQ2 | CLMN | S838 | ochoa | Calmin (Calponin-like transmembrane domain protein) | None |
Q96MR9 | ZNF560 | S169 | ochoa | Zinc finger protein 560 | May be involved in transcriptional regulation. |
Q96R06 | SPAG5 | S835 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
Q96R06 | SPAG5 | S974 | psp | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
Q96RR4 | CAMKK2 | S511 | psp | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
Q96T51 | RUFY1 | S319 | ochoa | RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) | Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity). {ECO:0000250|UniProtKB:Q8BIJ7, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}. |
Q99801 | NKX3-1 | S185 | psp | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
Q9BQL6 | FERMT1 | S502 | ochoa | Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}. |
Q9BRV8 | SIKE1 | S185 | ochoa|psp | Suppressor of IKBKE 1 (Suppressor of IKK-epsilon) | Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (PubMed:16281057). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:30622739). {ECO:0000269|PubMed:16281057, ECO:0000269|PubMed:30622739}. |
Q9BSW2 | CRACR2A | S263 | ochoa | EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46) (EC 3.6.5.2) | [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269|PubMed:20418871, ECO:0000269|PubMed:27016526}.; FUNCTION: [Isoform 2]: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (PubMed:31092558). During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function (PubMed:31092558). Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (PubMed:30814157). Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526). In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (PubMed:27016526). Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160). Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (PubMed:27016526). {ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:29987160, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. |
Q9BV73 | CEP250 | S264 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
Q9BXK5 | BCL2L13 | S50 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
Q9BY89 | KIAA1671 | S508 | ochoa | Uncharacterized protein KIAA1671 | None |
Q9BZF9 | UACA | S1353 | ochoa | Uveal autoantigen with coiled-coil domains and ankyrin repeats | Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). {ECO:0000250}.; FUNCTION: Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity). {ECO:0000250|UniProtKB:Q8CGB3, ECO:0000250|UniProtKB:Q8HYY4}. |
Q9C0B0 | UNK | S447 | ochoa | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
Q9H0A0 | NAT10 | S674 | ochoa | RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) | RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}. |
Q9H5N1 | RABEP2 | S193 | ochoa | Rab GTPase-binding effector protein 2 (Rabaptin-5beta) | Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062). {ECO:0000269|PubMed:27224062, ECO:0000269|PubMed:29425100, ECO:0000269|PubMed:9524116}. |
Q9H8X2 | IPPK | S109 | ochoa | Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase) | Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}. |
Q9HBI1 | PARVB | S254 | ochoa | Beta-parvin (Affixin) | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}. |
Q9HD20 | ATP13A1 | S935 | ochoa | Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) | Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). {ECO:0000269|PubMed:32973005, ECO:0000269|PubMed:36264797}. |
Q9NPI6 | DCP1A | S545 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
Q9NRA8 | EIF4ENIF1 | S417 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
Q9NRA8 | EIF4ENIF1 | S541 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
Q9NRD9 | DUOX1 | S634 | ochoa | Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 1) (Long NOX 1) (NADPH thyroid oxidase 1) (Thyroid oxidase 1) | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283}. |
Q9P0K7 | RAI14 | S915 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
Q9UBU7 | DBF4 | S420 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
Q9UHY8 | FEZ2 | S195 | ochoa | Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) | Involved in axonal outgrowth and fasciculation. {ECO:0000250}. |
Q9UKF6 | CPSF3 | S659 | ochoa | Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease (PubMed:30507380). Also involved in the histone 3'-end pre-mRNA processing (PubMed:30507380). U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for entering/progressing through S-phase of the cell cycle (PubMed:30507380). Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). {ECO:0000250|UniProtKB:Q9QXK7, ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:15037765, ECO:0000269|PubMed:17128255, ECO:0000269|PubMed:18688255, ECO:0000269|PubMed:30507380}. |
Q9UKL0 | RCOR1 | S127 | ochoa | REST corepressor 1 (Protein CoREST) | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}. |
Q9UKV3 | ACIN1 | S135 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
Q9UKX2 | MYH2 | T999 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
Q9UKX2 | MYH2 | S1245 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
Q9UKX2 | MYH2 | T1280 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
Q9UKX3 | MYH13 | S1482 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
Q9ULD2 | MTUS1 | S958 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
Q9ULD2 | MTUS1 | S1203 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
Q9UQE7 | SMC3 | S292 | ochoa | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
Q9Y210 | TRPC6 | S903 | ochoa | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
Q9Y2F5 | ICE1 | S693 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
Q9Y490 | TLN1 | S1021 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
Q9Y616 | IRAK3 | S332 | ochoa | Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}. |
Q9Y623 | MYH4 | T997 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
Q9Y623 | MYH4 | S1482 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
Q9Y6K9 | IKBKG | S196 | ochoa | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
P13489 | RNH1 | S290 | Sugiyama | Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625). {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889, ECO:0000269|PubMed:23843625, ECO:0000269|PubMed:3219362, ECO:0000269|PubMed:3243277, ECO:0000269|PubMed:32510170, ECO:0000269|PubMed:3470787, ECO:0000269|PubMed:9050852}. |
P53675 | CLTCL1 | S460 | Sugiyama | Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}. |
Q00610 | CLTC | S460 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
Q8NFD5 | ARID1B | S1744 | Sugiyama | AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B) (BRG1-associated factor 250b) (BAF250B) (BRG1-binding protein hELD/OSA1) (Osa homolog 2) (hOsa2) (p250R) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7, ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
P12270 | TPR | S135 | Sugiyama | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
Q8IX12 | CCAR1 | S1091 | Sugiyama | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}. |
Q9HB07 | MYG1 | S196 | Sugiyama | MYG1 exonuclease (EC 3.1.-.-) | 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}. |
O43252 | PAPSS1 | S231 | Sugiyama | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:14747722, PubMed:9576487, PubMed:9648242, PubMed:9668121). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). {ECO:0000269|PubMed:14747722, ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242, ECO:0000269|PubMed:9668121}. |
Q04917 | YWHAH | S38 | Sugiyama | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
P33176 | KIF5B | S443 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
O60610 | DIAPH1 | T545 | Sugiyama | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
O60763 | USO1 | S805 | Sugiyama | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
O95721 | SNAP29 | S210 | Sugiyama | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
Q6XUX3 | DSTYK | S337 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
P22314 | UBA1 | S460 | Sugiyama | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
Q9BQ39 | DDX50 | S145 | Sugiyama | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
P01130 | LDLR | S286 | Sugiyama | Low-density lipoprotein receptor (LDL receptor) | Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization (PubMed:30443021). {ECO:0000269|PubMed:3005267, ECO:0000269|PubMed:30443021, ECO:0000269|PubMed:6091915}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. {ECO:0000269|PubMed:10535997, ECO:0000269|PubMed:12615904}.; FUNCTION: (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. {ECO:0000269|PubMed:23589850}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. {ECO:0000269|PubMed:11100124}.; FUNCTION: (Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV). {ECO:0000269|PubMed:38182887}.; FUNCTION: (Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus. {ECO:0000269|PubMed:38245515}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-1640170 | Cell Cycle | 2.704839e-07 | 6.568 |
R-HSA-199991 | Membrane Trafficking | 5.698681e-06 | 5.244 |
R-HSA-69278 | Cell Cycle, Mitotic | 6.512103e-06 | 5.186 |
R-HSA-68886 | M Phase | 1.267994e-05 | 4.897 |
R-HSA-5357801 | Programmed Cell Death | 1.596110e-05 | 4.797 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 2.814683e-05 | 4.551 |
R-HSA-69481 | G2/M Checkpoints | 3.040334e-05 | 4.517 |
R-HSA-109581 | Apoptosis | 4.387638e-05 | 4.358 |
R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 9.664506e-05 | 4.015 |
R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.476346e-04 | 3.831 |
R-HSA-69620 | Cell Cycle Checkpoints | 1.333711e-04 | 3.875 |
R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.476346e-04 | 3.831 |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.476346e-04 | 3.831 |
R-HSA-5653656 | Vesicle-mediated transport | 1.812076e-04 | 3.742 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.930364e-04 | 3.714 |
R-HSA-390522 | Striated Muscle Contraction | 2.440656e-04 | 3.612 |
R-HSA-68877 | Mitotic Prometaphase | 7.388222e-04 | 3.131 |
R-HSA-352238 | Breakdown of the nuclear lamina | 8.065171e-04 | 3.093 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 9.314490e-04 | 3.031 |
R-HSA-75153 | Apoptotic execution phase | 9.391488e-04 | 3.027 |
R-HSA-69473 | G2/M DNA damage checkpoint | 9.914958e-04 | 3.004 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.200979e-03 | 2.920 |
R-HSA-1221632 | Meiotic synapsis | 1.600672e-03 | 2.796 |
R-HSA-114452 | Activation of BH3-only proteins | 1.590056e-03 | 2.799 |
R-HSA-1500620 | Meiosis | 1.866931e-03 | 2.729 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.969630e-03 | 2.706 |
R-HSA-176187 | Activation of ATR in response to replication stress | 2.122076e-03 | 2.673 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.299106e-03 | 2.638 |
R-HSA-68875 | Mitotic Prophase | 2.607572e-03 | 2.584 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.067400e-03 | 2.513 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.067400e-03 | 2.513 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.007035e-03 | 2.522 |
R-HSA-2132295 | MHC class II antigen presentation | 2.943475e-03 | 2.531 |
R-HSA-8854518 | AURKA Activation by TPX2 | 3.651868e-03 | 2.437 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.998667e-03 | 2.398 |
R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 4.236870e-03 | 2.373 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.319669e-03 | 2.274 |
R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 5.484779e-03 | 2.261 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.053640e-03 | 2.296 |
R-HSA-380287 | Centrosome maturation | 5.881190e-03 | 2.231 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.143225e-03 | 2.212 |
R-HSA-9700206 | Signaling by ALK in cancer | 6.143225e-03 | 2.212 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 5.904775e-03 | 2.229 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 6.217661e-03 | 2.206 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 6.880160e-03 | 2.162 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 7.395438e-03 | 2.131 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 8.418839e-03 | 2.075 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 8.280052e-03 | 2.082 |
R-HSA-8863678 | Neurodegenerative Diseases | 8.280052e-03 | 2.082 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.930221e-03 | 2.049 |
R-HSA-69306 | DNA Replication | 9.483559e-03 | 2.023 |
R-HSA-196025 | Formation of annular gap junctions | 1.009672e-02 | 1.996 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.069969e-02 | 1.971 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.069969e-02 | 1.971 |
R-HSA-190873 | Gap junction degradation | 1.190981e-02 | 1.924 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.195106e-02 | 1.923 |
R-HSA-430116 | GP1b-IX-V activation signalling | 1.190981e-02 | 1.924 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 1.247980e-02 | 1.904 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.251665e-02 | 1.903 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.385417e-02 | 1.858 |
R-HSA-68962 | Activation of the pre-replicative complex | 1.348725e-02 | 1.870 |
R-HSA-983189 | Kinesins | 1.449017e-02 | 1.839 |
R-HSA-182971 | EGFR downregulation | 1.449959e-02 | 1.839 |
R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.592597e-02 | 1.798 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.617660e-02 | 1.791 |
R-HSA-1474165 | Reproduction | 1.556728e-02 | 1.808 |
R-HSA-397014 | Muscle contraction | 1.489057e-02 | 1.827 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.523886e-02 | 1.817 |
R-HSA-68882 | Mitotic Anaphase | 1.631925e-02 | 1.787 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.669139e-02 | 1.778 |
R-HSA-373755 | Semaphorin interactions | 1.669455e-02 | 1.777 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.774726e-02 | 1.751 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.827453e-02 | 1.738 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.129634e-02 | 1.672 |
R-HSA-69275 | G2/M Transition | 2.310415e-02 | 1.636 |
R-HSA-913531 | Interferon Signaling | 2.348843e-02 | 1.629 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.355900e-02 | 1.628 |
R-HSA-453274 | Mitotic G2-G2/M phases | 2.418604e-02 | 1.616 |
R-HSA-69002 | DNA Replication Pre-Initiation | 2.576034e-02 | 1.589 |
R-HSA-446353 | Cell-extracellular matrix interactions | 2.806734e-02 | 1.552 |
R-HSA-5617833 | Cilium Assembly | 2.530233e-02 | 1.597 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.806734e-02 | 1.552 |
R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 3.082734e-02 | 1.511 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.141502e-02 | 1.503 |
R-HSA-909733 | Interferon alpha/beta signaling | 3.258505e-02 | 1.487 |
R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.368999e-02 | 1.472 |
R-HSA-5210891 | Uptake and function of anthrax toxins | 3.665205e-02 | 1.436 |
R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.665205e-02 | 1.436 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.526825e-02 | 1.453 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.306534e-02 | 1.481 |
R-HSA-877300 | Interferon gamma signaling | 3.524002e-02 | 1.453 |
R-HSA-2028269 | Signaling by Hippo | 3.665205e-02 | 1.436 |
R-HSA-6802957 | Oncogenic MAPK signaling | 3.918485e-02 | 1.407 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 3.971035e-02 | 1.401 |
R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 3.998239e-02 | 1.398 |
R-HSA-5602636 | IKBKB deficiency causes SCID | 3.998239e-02 | 1.398 |
R-HSA-5620916 | VxPx cargo-targeting to cilium | 4.610323e-02 | 1.336 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 4.610323e-02 | 1.336 |
R-HSA-9645723 | Diseases of programmed cell death | 4.451545e-02 | 1.351 |
R-HSA-6807004 | Negative regulation of MET activity | 4.610323e-02 | 1.336 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 4.393830e-02 | 1.357 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 4.180178e-02 | 1.379 |
R-HSA-8964026 | Chylomicron clearance | 1.152355e-01 | 0.938 |
R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.152355e-01 | 0.938 |
R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 1.271938e-01 | 0.896 |
R-HSA-9700645 | ALK mutants bind TKIs | 1.506299e-01 | 0.822 |
R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.621119e-01 | 0.790 |
R-HSA-164843 | 2-LTR circle formation | 1.621119e-01 | 0.790 |
R-HSA-9615710 | Late endosomal microautophagy | 8.284568e-02 | 1.082 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 8.284568e-02 | 1.082 |
R-HSA-177504 | Retrograde neurotrophin signalling | 2.172454e-01 | 0.663 |
R-HSA-1295596 | Spry regulation of FGF signaling | 2.278308e-01 | 0.642 |
R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.382738e-01 | 0.623 |
R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 2.382738e-01 | 0.623 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.485761e-01 | 0.605 |
R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.587397e-01 | 0.587 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.302205e-01 | 0.885 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.347914e-01 | 0.870 |
R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.393979e-01 | 0.856 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.786583e-01 | 0.555 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.884168e-01 | 0.540 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.884168e-01 | 0.540 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.884168e-01 | 0.540 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.884168e-01 | 0.540 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.884168e-01 | 0.540 |
R-HSA-72649 | Translation initiation complex formation | 2.067019e-01 | 0.685 |
R-HSA-3214815 | HDACs deacetylate histones | 2.116504e-01 | 0.674 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.166105e-01 | 0.664 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.365434e-01 | 0.626 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 1.665070e-01 | 0.779 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.347022e-02 | 1.272 |
R-HSA-72172 | mRNA Splicing | 1.914447e-01 | 0.718 |
R-HSA-9646399 | Aggrephagy | 1.347914e-01 | 0.870 |
R-HSA-9842860 | Regulation of endogenous retroelements | 2.000281e-01 | 0.699 |
R-HSA-912694 | Regulation of IFNA/IFNB signaling | 3.169110e-01 | 0.499 |
R-HSA-6804757 | Regulation of TP53 Degradation | 1.167400e-01 | 0.933 |
R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.389912e-01 | 0.857 |
R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 2.065155e-01 | 0.685 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.143833e-02 | 1.289 |
R-HSA-2025928 | Calcineurin activates NFAT | 1.506299e-01 | 0.822 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 9.938054e-02 | 1.003 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.211929e-01 | 0.917 |
R-HSA-5674135 | MAP2K and MAPK activation | 1.440382e-01 | 0.842 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.302205e-01 | 0.885 |
R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 9.938054e-02 | 1.003 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 7.039903e-02 | 1.152 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.079658e-01 | 0.967 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.137519e-01 | 0.944 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.172454e-01 | 0.663 |
R-HSA-9656223 | Signaling by RAF1 mutants | 1.440382e-01 | 0.842 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 1.676879e-01 | 0.775 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.676879e-01 | 0.775 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.676879e-01 | 0.775 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.570176e-01 | 0.590 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.079658e-01 | 0.967 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.716134e-01 | 0.566 |
R-HSA-69541 | Stabilization of p53 | 1.302205e-01 | 0.885 |
R-HSA-5693538 | Homology Directed Repair | 2.678644e-01 | 0.572 |
R-HSA-68867 | Assembly of the pre-replicative complex | 1.662278e-01 | 0.779 |
R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.031141e-01 | 0.987 |
R-HSA-68689 | CDC6 association with the ORC:origin complex | 1.031141e-01 | 0.987 |
R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.506299e-01 | 0.822 |
R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.621119e-01 | 0.790 |
R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.846145e-01 | 0.734 |
R-HSA-8866427 | VLDLR internalisation and degradation | 1.956392e-01 | 0.709 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.065155e-01 | 0.685 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.065155e-01 | 0.685 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.172454e-01 | 0.663 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.278308e-01 | 0.642 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.278308e-01 | 0.642 |
R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.278308e-01 | 0.642 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.079658e-01 | 0.967 |
R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.687665e-01 | 0.571 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.687665e-01 | 0.571 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.347914e-01 | 0.870 |
R-HSA-68949 | Orc1 removal from chromatin | 1.968448e-01 | 0.706 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.968448e-01 | 0.706 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.352731e-01 | 0.475 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.352731e-01 | 0.475 |
R-HSA-2467813 | Separation of Sister Chromatids | 1.043886e-01 | 0.981 |
R-HSA-3214858 | RMTs methylate histone arginines | 1.581450e-01 | 0.801 |
R-HSA-8964038 | LDL clearance | 5.633852e-02 | 1.249 |
R-HSA-6802949 | Signaling by RAS mutants | 1.676879e-01 | 0.775 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.916521e-01 | 0.535 |
R-HSA-8964043 | Plasma lipoprotein clearance | 1.302205e-01 | 0.885 |
R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.031141e-01 | 0.987 |
R-HSA-174362 | Transport and metabolism of PAPS | 2.278308e-01 | 0.642 |
R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.382738e-01 | 0.623 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.256870e-01 | 0.901 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 9.137207e-02 | 1.039 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.169110e-01 | 0.499 |
R-HSA-9766229 | Degradation of CDH1 | 1.821783e-01 | 0.740 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.919387e-01 | 0.717 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.966528e-01 | 0.528 |
R-HSA-9764561 | Regulation of CDH1 Function | 5.988289e-02 | 1.223 |
R-HSA-204005 | COPII-mediated vesicle transport | 2.866470e-01 | 0.543 |
R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 9.100126e-02 | 1.041 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 8.614846e-02 | 1.065 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.821783e-01 | 0.740 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.821783e-01 | 0.740 |
R-HSA-1236974 | ER-Phagosome pathway | 1.500266e-01 | 0.824 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 2.051341e-01 | 0.688 |
R-HSA-205025 | NADE modulates death signalling | 7.837320e-02 | 1.106 |
R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.278308e-01 | 0.642 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.485761e-01 | 0.605 |
R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.347914e-01 | 0.870 |
R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.347914e-01 | 0.870 |
R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.786583e-01 | 0.555 |
R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.980439e-01 | 0.526 |
R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.980439e-01 | 0.526 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.676879e-01 | 0.775 |
R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.352731e-01 | 0.475 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.265608e-01 | 0.645 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.534902e-01 | 0.814 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.347914e-01 | 0.870 |
R-HSA-8953854 | Metabolism of RNA | 7.732308e-02 | 1.112 |
R-HSA-400685 | Sema4D in semaphorin signaling | 6.728073e-02 | 1.172 |
R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.389912e-01 | 0.857 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.506299e-01 | 0.822 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.256870e-01 | 0.901 |
R-HSA-6811438 | Intra-Golgi traffic | 1.440382e-01 | 0.842 |
R-HSA-69052 | Switching of origins to a post-replicative state | 3.016483e-01 | 0.520 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.192389e-01 | 0.659 |
R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 7.493237e-02 | 1.125 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.123303e-01 | 0.950 |
R-HSA-2408550 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | 2.587397e-01 | 0.587 |
R-HSA-392517 | Rap1 signalling | 2.786583e-01 | 0.555 |
R-HSA-6784531 | tRNA processing in the nucleus | 2.465495e-01 | 0.608 |
R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.382738e-01 | 0.623 |
R-HSA-9018519 | Estrogen-dependent gene expression | 5.934302e-02 | 1.227 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.515587e-01 | 0.599 |
R-HSA-5633007 | Regulation of TP53 Activity | 2.249532e-01 | 0.648 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.629037e-01 | 0.788 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 1.085801e-01 | 0.964 |
R-HSA-937039 | IRAK1 recruits IKK complex | 1.956392e-01 | 0.709 |
R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.956392e-01 | 0.709 |
R-HSA-418890 | Role of second messengers in netrin-1 signaling | 1.956392e-01 | 0.709 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 7.493237e-02 | 1.125 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 8.284568e-02 | 1.082 |
R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.172454e-01 | 0.663 |
R-HSA-69166 | Removal of the Flap Intermediate | 2.172454e-01 | 0.663 |
R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.278308e-01 | 0.642 |
R-HSA-445355 | Smooth Muscle Contraction | 5.143833e-02 | 1.289 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 2.786583e-01 | 0.555 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 9.672431e-02 | 1.014 |
R-HSA-429947 | Deadenylation of mRNA | 3.352731e-01 | 0.475 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.952772e-02 | 1.225 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.916521e-01 | 0.535 |
R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.621119e-01 | 0.790 |
R-HSA-72312 | rRNA processing | 2.600313e-01 | 0.585 |
R-HSA-2022870 | CS-GAG biosynthesis | 3.075414e-01 | 0.512 |
R-HSA-162592 | Integration of provirus | 1.846145e-01 | 0.734 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.000281e-01 | 0.699 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.393979e-01 | 0.856 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.533052e-01 | 0.596 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.599792e-01 | 0.585 |
R-HSA-162909 | Host Interactions of HIV factors | 1.205388e-01 | 0.919 |
R-HSA-9020702 | Interleukin-1 signaling | 1.965747e-01 | 0.706 |
R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.506299e-01 | 0.822 |
R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.734395e-01 | 0.761 |
R-HSA-399956 | CRMPs in Sema3A signaling | 2.172454e-01 | 0.663 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.278308e-01 | 0.642 |
R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.382738e-01 | 0.623 |
R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.587397e-01 | 0.587 |
R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.587397e-01 | 0.587 |
R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 2.786583e-01 | 0.555 |
R-HSA-190828 | Gap junction trafficking | 1.581450e-01 | 0.801 |
R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.075414e-01 | 0.512 |
R-HSA-416482 | G alpha (12/13) signalling events | 1.135138e-01 | 0.945 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.315486e-01 | 0.635 |
R-HSA-1236975 | Antigen processing-Cross presentation | 2.245812e-01 | 0.649 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.165958e-01 | 0.499 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.687665e-01 | 0.571 |
R-HSA-69242 | S Phase | 7.784749e-02 | 1.109 |
R-HSA-114608 | Platelet degranulation | 1.298523e-01 | 0.887 |
R-HSA-177929 | Signaling by EGFR | 5.771405e-02 | 1.239 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.135138e-01 | 0.945 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 1.831849e-01 | 0.737 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.751418e-01 | 0.757 |
R-HSA-1280218 | Adaptive Immune System | 2.850044e-01 | 0.545 |
R-HSA-1483249 | Inositol phosphate metabolism | 2.388681e-01 | 0.622 |
R-HSA-9627069 | Regulation of the apoptosome activity | 1.621119e-01 | 0.790 |
R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.956392e-01 | 0.709 |
R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.956392e-01 | 0.709 |
R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.065155e-01 | 0.685 |
R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.278308e-01 | 0.642 |
R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 2.382738e-01 | 0.623 |
R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.587397e-01 | 0.587 |
R-HSA-1614517 | Sulfide oxidation to sulfate | 2.587397e-01 | 0.587 |
R-HSA-157858 | Gap junction trafficking and regulation | 1.821783e-01 | 0.740 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.297623e-02 | 1.276 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.245812e-01 | 0.649 |
R-HSA-4086400 | PCP/CE pathway | 3.265213e-01 | 0.486 |
R-HSA-69206 | G1/S Transition | 1.251585e-01 | 0.903 |
R-HSA-73886 | Chromosome Maintenance | 2.788477e-01 | 0.555 |
R-HSA-8939211 | ESR-mediated signaling | 2.728728e-01 | 0.564 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 9.672431e-02 | 1.014 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.116205e-01 | 0.506 |
R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.261543e-01 | 0.487 |
R-HSA-5689880 | Ub-specific processing proteases | 1.229747e-01 | 0.910 |
R-HSA-9013694 | Signaling by NOTCH4 | 3.066377e-01 | 0.513 |
R-HSA-74160 | Gene expression (Transcription) | 1.798681e-01 | 0.745 |
R-HSA-69239 | Synthesis of DNA | 2.210363e-01 | 0.656 |
R-HSA-9675135 | Diseases of DNA repair | 1.676879e-01 | 0.775 |
R-HSA-69183 | Processive synthesis on the lagging strand | 2.278308e-01 | 0.642 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.988289e-02 | 1.223 |
R-HSA-193648 | NRAGE signals death through JNK | 2.166105e-01 | 0.664 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.468397e-01 | 0.833 |
R-HSA-73864 | RNA Polymerase I Transcription | 3.265213e-01 | 0.486 |
R-HSA-5688426 | Deubiquitination | 1.740830e-01 | 0.759 |
R-HSA-446652 | Interleukin-1 family signaling | 8.410041e-02 | 1.075 |
R-HSA-9679191 | Potential therapeutics for SARS | 1.968051e-01 | 0.706 |
R-HSA-3371556 | Cellular response to heat stress | 2.788477e-01 | 0.555 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.123303e-01 | 0.950 |
R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.271938e-01 | 0.896 |
R-HSA-8849932 | Synaptic adhesion-like molecules | 2.687665e-01 | 0.571 |
R-HSA-1169408 | ISG15 antiviral mechanism | 3.116205e-01 | 0.506 |
R-HSA-109582 | Hemostasis | 2.090220e-01 | 0.680 |
R-HSA-264876 | Insulin processing | 7.493237e-02 | 1.125 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 9.944747e-02 | 1.002 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.956392e-01 | 0.709 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 1.036485e-01 | 0.984 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.440382e-01 | 0.842 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.724960e-01 | 0.763 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.422549e-02 | 1.192 |
R-HSA-168898 | Toll-like Receptor Cascades | 1.599441e-01 | 0.796 |
R-HSA-162594 | Early Phase of HIV Life Cycle | 4.943178e-02 | 1.306 |
R-HSA-73857 | RNA Polymerase II Transcription | 1.297268e-01 | 0.887 |
R-HSA-168256 | Immune System | 1.622046e-01 | 0.790 |
R-HSA-212436 | Generic Transcription Pathway | 1.241995e-01 | 0.906 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.389912e-01 | 0.857 |
R-HSA-111458 | Formation of apoptosome | 1.621119e-01 | 0.790 |
R-HSA-9842663 | Signaling by LTK | 1.956392e-01 | 0.709 |
R-HSA-1855191 | Synthesis of IPs in the nucleus | 2.172454e-01 | 0.663 |
R-HSA-9836573 | Mitochondrial RNA degradation | 3.352731e-01 | 0.475 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.858694e-01 | 0.731 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.659224e-01 | 0.575 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.659224e-01 | 0.575 |
R-HSA-9675108 | Nervous system development | 2.009193e-01 | 0.697 |
R-HSA-202403 | TCR signaling | 2.317041e-01 | 0.635 |
R-HSA-162906 | HIV Infection | 1.227732e-01 | 0.911 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 8.689437e-02 | 1.061 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.485761e-01 | 0.605 |
R-HSA-69186 | Lagging Strand Synthesis | 2.980439e-01 | 0.526 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.968448e-01 | 0.706 |
R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.846145e-01 | 0.734 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.687665e-01 | 0.571 |
R-HSA-9012852 | Signaling by NOTCH3 | 5.558343e-02 | 1.255 |
R-HSA-446728 | Cell junction organization | 2.217613e-01 | 0.654 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.866470e-01 | 0.543 |
R-HSA-9824446 | Viral Infection Pathways | 6.633140e-02 | 1.178 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 2.069779e-01 | 0.684 |
R-HSA-162582 | Signal Transduction | 8.515690e-02 | 1.070 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 5.284450e-02 | 1.277 |
R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.980439e-01 | 0.526 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.405662e-01 | 0.852 |
R-HSA-2262752 | Cellular responses to stress | 1.751219e-01 | 0.757 |
R-HSA-5218859 | Regulated Necrosis | 2.766268e-01 | 0.558 |
R-HSA-8953897 | Cellular responses to stimuli | 1.697937e-01 | 0.770 |
R-HSA-9008059 | Interleukin-37 signaling | 8.689437e-02 | 1.061 |
R-HSA-2682334 | EPH-Ephrin signaling | 5.172192e-02 | 1.286 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.169110e-01 | 0.499 |
R-HSA-180786 | Extension of Telomeres | 2.315486e-01 | 0.635 |
R-HSA-9856651 | MITF-M-dependent gene expression | 1.968051e-01 | 0.706 |
R-HSA-1500931 | Cell-Cell communication | 3.082081e-01 | 0.511 |
R-HSA-5663205 | Infectious disease | 1.763224e-01 | 0.754 |
R-HSA-8983711 | OAS antiviral response | 1.956392e-01 | 0.709 |
R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.169110e-01 | 0.499 |
R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 3.261543e-01 | 0.487 |
R-HSA-157118 | Signaling by NOTCH | 1.455727e-01 | 0.837 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.460696e-01 | 0.609 |
R-HSA-162587 | HIV Life Cycle | 2.163968e-01 | 0.665 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 9.860936e-02 | 1.006 |
R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.079658e-01 | 0.967 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.079334e-01 | 0.682 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.261543e-01 | 0.487 |
R-HSA-8854691 | Interleukin-20 family signaling | 3.261543e-01 | 0.487 |
R-HSA-1834941 | STING mediated induction of host immune responses | 2.786583e-01 | 0.555 |
R-HSA-73887 | Death Receptor Signaling | 2.079334e-01 | 0.682 |
R-HSA-9694516 | SARS-CoV-2 Infection | 6.702242e-02 | 1.174 |
R-HSA-449147 | Signaling by Interleukins | 1.724778e-01 | 0.763 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.581450e-01 | 0.801 |
R-HSA-9679506 | SARS-CoV Infections | 9.637948e-02 | 1.016 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.968448e-01 | 0.706 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.897134e-01 | 0.722 |
R-HSA-381070 | IRE1alpha activates chaperones | 5.023249e-02 | 1.299 |
R-HSA-111471 | Apoptotic factor-mediated response | 2.687665e-01 | 0.571 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.615844e-01 | 0.582 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 1.646379e-01 | 0.783 |
R-HSA-9678108 | SARS-CoV-1 Infection | 5.082154e-02 | 1.294 |
R-HSA-9020591 | Interleukin-12 signaling | 3.165958e-01 | 0.499 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.356259e-01 | 0.474 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 3.364087e-01 | 0.473 |
R-HSA-6806834 | Signaling by MET | 3.364087e-01 | 0.473 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 3.413366e-01 | 0.467 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.442691e-01 | 0.463 |
R-HSA-3214842 | HDMs demethylate histones | 3.442691e-01 | 0.463 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.442691e-01 | 0.463 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.442691e-01 | 0.463 |
R-HSA-1266695 | Interleukin-7 signaling | 3.442691e-01 | 0.463 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.452825e-01 | 0.462 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.462531e-01 | 0.461 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.531439e-01 | 0.452 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.531439e-01 | 0.452 |
R-HSA-5689901 | Metalloprotease DUBs | 3.531439e-01 | 0.452 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 3.531439e-01 | 0.452 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.531439e-01 | 0.452 |
R-HSA-3295583 | TRP channels | 3.531439e-01 | 0.452 |
R-HSA-70635 | Urea cycle | 3.531439e-01 | 0.452 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.531439e-01 | 0.452 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.560495e-01 | 0.448 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.570935e-01 | 0.447 |
R-HSA-6794362 | Protein-protein interactions at synapses | 3.609283e-01 | 0.443 |
R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.618991e-01 | 0.441 |
R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.618991e-01 | 0.441 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.618991e-01 | 0.441 |
R-HSA-422475 | Axon guidance | 3.645466e-01 | 0.438 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.657935e-01 | 0.437 |
R-HSA-141424 | Amplification of signal from the kinetochores | 3.657935e-01 | 0.437 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.705363e-01 | 0.431 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.705363e-01 | 0.431 |
R-HSA-9638334 | Iron assimilation using enterobactin | 3.705363e-01 | 0.431 |
R-HSA-5620971 | Pyroptosis | 3.705363e-01 | 0.431 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.705363e-01 | 0.431 |
R-HSA-447115 | Interleukin-12 family signaling | 3.754808e-01 | 0.425 |
R-HSA-1643685 | Disease | 3.761809e-01 | 0.425 |
R-HSA-5334118 | DNA methylation | 3.790572e-01 | 0.421 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.790572e-01 | 0.421 |
R-HSA-209968 | Thyroxine biosynthesis | 3.790572e-01 | 0.421 |
R-HSA-180024 | DARPP-32 events | 3.790572e-01 | 0.421 |
R-HSA-418360 | Platelet calcium homeostasis | 3.790572e-01 | 0.421 |
R-HSA-9006335 | Signaling by Erythropoietin | 3.790572e-01 | 0.421 |
R-HSA-9663891 | Selective autophagy | 3.803020e-01 | 0.420 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.874632e-01 | 0.412 |
R-HSA-2424491 | DAP12 signaling | 3.874632e-01 | 0.412 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.874632e-01 | 0.412 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 3.893914e-01 | 0.410 |
R-HSA-202424 | Downstream TCR signaling | 3.898970e-01 | 0.409 |
R-HSA-73884 | Base Excision Repair | 3.898970e-01 | 0.409 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.930398e-01 | 0.406 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.957560e-01 | 0.403 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.957560e-01 | 0.403 |
R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.957560e-01 | 0.403 |
R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.957560e-01 | 0.403 |
R-HSA-399719 | Trafficking of AMPA receptors | 3.957560e-01 | 0.403 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.957560e-01 | 0.403 |
R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.039370e-01 | 0.394 |
R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.039370e-01 | 0.394 |
R-HSA-69190 | DNA strand elongation | 4.039370e-01 | 0.394 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 4.041644e-01 | 0.393 |
R-HSA-418990 | Adherens junctions interactions | 4.060490e-01 | 0.391 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.120077e-01 | 0.385 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.120077e-01 | 0.385 |
R-HSA-354192 | Integrin signaling | 4.120077e-01 | 0.385 |
R-HSA-9930044 | Nuclear RNA decay | 4.120077e-01 | 0.385 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 4.120077e-01 | 0.385 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.120077e-01 | 0.385 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.120077e-01 | 0.385 |
R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.120077e-01 | 0.385 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.120077e-01 | 0.385 |
R-HSA-5675482 | Regulation of necroptotic cell death | 4.120077e-01 | 0.385 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.120077e-01 | 0.385 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.182720e-01 | 0.379 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.199696e-01 | 0.377 |
R-HSA-5693537 | Resolution of D-Loop Structures | 4.199696e-01 | 0.377 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.199696e-01 | 0.377 |
R-HSA-180534 | Vpu mediated degradation of CD4 | 4.199696e-01 | 0.377 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 4.199696e-01 | 0.377 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 4.229373e-01 | 0.374 |
R-HSA-9610379 | HCMV Late Events | 4.255983e-01 | 0.371 |
R-HSA-6807878 | COPI-mediated anterograde transport | 4.275833e-01 | 0.369 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 4.278242e-01 | 0.369 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 4.278242e-01 | 0.369 |
R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 4.278242e-01 | 0.369 |
R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.278242e-01 | 0.369 |
R-HSA-180746 | Nuclear import of Rev protein | 4.278242e-01 | 0.369 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.278242e-01 | 0.369 |
R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 4.278242e-01 | 0.369 |
R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 4.278242e-01 | 0.369 |
R-HSA-901042 | Calnexin/calreticulin cycle | 4.278242e-01 | 0.369 |
R-HSA-1980145 | Signaling by NOTCH2 | 4.278242e-01 | 0.369 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.322097e-01 | 0.364 |
R-HSA-157579 | Telomere Maintenance | 4.322097e-01 | 0.364 |
R-HSA-195721 | Signaling by WNT | 4.349700e-01 | 0.362 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.355729e-01 | 0.361 |
R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 4.355729e-01 | 0.361 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.355729e-01 | 0.361 |
R-HSA-169911 | Regulation of Apoptosis | 4.355729e-01 | 0.361 |
R-HSA-2559585 | Oncogene Induced Senescence | 4.355729e-01 | 0.361 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.355729e-01 | 0.361 |
R-HSA-3214847 | HATs acetylate histones | 4.414026e-01 | 0.355 |
R-HSA-9614085 | FOXO-mediated transcription | 4.414026e-01 | 0.355 |
R-HSA-212300 | PRC2 methylates histones and DNA | 4.432172e-01 | 0.353 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.432172e-01 | 0.353 |
R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 4.432172e-01 | 0.353 |
R-HSA-9682385 | FLT3 signaling in disease | 4.432172e-01 | 0.353 |
R-HSA-3371511 | HSF1 activation | 4.432172e-01 | 0.353 |
R-HSA-111933 | Calmodulin induced events | 4.432172e-01 | 0.353 |
R-HSA-111997 | CaM pathway | 4.432172e-01 | 0.353 |
R-HSA-114604 | GPVI-mediated activation cascade | 4.432172e-01 | 0.353 |
R-HSA-8941326 | RUNX2 regulates bone development | 4.432172e-01 | 0.353 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 4.459685e-01 | 0.351 |
R-HSA-5610787 | Hedgehog 'off' state | 4.459685e-01 | 0.351 |
R-HSA-2408522 | Selenoamino acid metabolism | 4.505029e-01 | 0.346 |
R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.507584e-01 | 0.346 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.507584e-01 | 0.346 |
R-HSA-110331 | Cleavage of the damaged purine | 4.507584e-01 | 0.346 |
R-HSA-4641258 | Degradation of DVL | 4.507584e-01 | 0.346 |
R-HSA-4641257 | Degradation of AXIN | 4.507584e-01 | 0.346 |
R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4.507584e-01 | 0.346 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.507584e-01 | 0.346 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.507584e-01 | 0.346 |
R-HSA-5689896 | Ovarian tumor domain proteases | 4.507584e-01 | 0.346 |
R-HSA-196757 | Metabolism of folate and pterines | 4.507584e-01 | 0.346 |
R-HSA-3247509 | Chromatin modifying enzymes | 4.542767e-01 | 0.343 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.550377e-01 | 0.342 |
R-HSA-73927 | Depurination | 4.581979e-01 | 0.339 |
R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.581979e-01 | 0.339 |
R-HSA-111885 | Opioid Signalling | 4.640216e-01 | 0.333 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.655371e-01 | 0.332 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.655371e-01 | 0.332 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.655371e-01 | 0.332 |
R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.655371e-01 | 0.332 |
R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 4.655371e-01 | 0.332 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.711928e-01 | 0.327 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.727773e-01 | 0.325 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.727773e-01 | 0.325 |
R-HSA-5260271 | Diseases of Immune System | 4.727773e-01 | 0.325 |
R-HSA-202433 | Generation of second messenger molecules | 4.727773e-01 | 0.325 |
R-HSA-379726 | Mitochondrial tRNA aminoacylation | 4.727773e-01 | 0.325 |
R-HSA-6798695 | Neutrophil degranulation | 4.747842e-01 | 0.324 |
R-HSA-3214841 | PKMTs methylate histone lysines | 4.799199e-01 | 0.319 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.799199e-01 | 0.319 |
R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.799199e-01 | 0.319 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.799199e-01 | 0.319 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.799199e-01 | 0.319 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.799199e-01 | 0.319 |
R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.799199e-01 | 0.319 |
R-HSA-211000 | Gene Silencing by RNA | 4.817261e-01 | 0.317 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.860961e-01 | 0.313 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.860961e-01 | 0.313 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 4.869662e-01 | 0.313 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.869662e-01 | 0.313 |
R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.869662e-01 | 0.313 |
R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.869662e-01 | 0.313 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.904432e-01 | 0.309 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.939174e-01 | 0.306 |
R-HSA-111996 | Ca-dependent events | 4.939174e-01 | 0.306 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.939174e-01 | 0.306 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.953607e-01 | 0.305 |
R-HSA-4839726 | Chromatin organization | 4.982939e-01 | 0.303 |
R-HSA-212165 | Epigenetic regulation of gene expression | 5.001921e-01 | 0.301 |
R-HSA-9710421 | Defective pyroptosis | 5.007749e-01 | 0.300 |
R-HSA-5654743 | Signaling by FGFR4 | 5.007749e-01 | 0.300 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 5.007749e-01 | 0.300 |
R-HSA-8854214 | TBC/RABGAPs | 5.007749e-01 | 0.300 |
R-HSA-1433557 | Signaling by SCF-KIT | 5.007749e-01 | 0.300 |
R-HSA-9609646 | HCMV Infection | 5.011765e-01 | 0.300 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.033457e-01 | 0.298 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.033457e-01 | 0.298 |
R-HSA-421270 | Cell-cell junction organization | 5.040520e-01 | 0.298 |
R-HSA-168255 | Influenza Infection | 5.056596e-01 | 0.296 |
R-HSA-2172127 | DAP12 interactions | 5.075398e-01 | 0.295 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 5.075398e-01 | 0.295 |
R-HSA-9907900 | Proteasome assembly | 5.075398e-01 | 0.295 |
R-HSA-3928662 | EPHB-mediated forward signaling | 5.075398e-01 | 0.295 |
R-HSA-373752 | Netrin-1 signaling | 5.075398e-01 | 0.295 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.075996e-01 | 0.294 |
R-HSA-2559583 | Cellular Senescence | 5.090138e-01 | 0.293 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.118299e-01 | 0.291 |
R-HSA-774815 | Nucleosome assembly | 5.142136e-01 | 0.289 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.142136e-01 | 0.289 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.142136e-01 | 0.289 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.142136e-01 | 0.289 |
R-HSA-5654741 | Signaling by FGFR3 | 5.142136e-01 | 0.289 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 5.142136e-01 | 0.289 |
R-HSA-6783310 | Fanconi Anemia Pathway | 5.142136e-01 | 0.289 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 5.142136e-01 | 0.289 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.142136e-01 | 0.289 |
R-HSA-1489509 | DAG and IP3 signaling | 5.142136e-01 | 0.289 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 5.142136e-01 | 0.289 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 5.142136e-01 | 0.289 |
R-HSA-9824272 | Somitogenesis | 5.142136e-01 | 0.289 |
R-HSA-1614558 | Degradation of cysteine and homocysteine | 5.142136e-01 | 0.289 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 5.190049e-01 | 0.285 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.207972e-01 | 0.283 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.207972e-01 | 0.283 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 5.207972e-01 | 0.283 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.207972e-01 | 0.283 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 5.207972e-01 | 0.283 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 5.243774e-01 | 0.280 |
R-HSA-437239 | Recycling pathway of L1 | 5.272921e-01 | 0.278 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.272921e-01 | 0.278 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 5.272921e-01 | 0.278 |
R-HSA-72737 | Cap-dependent Translation Initiation | 5.285117e-01 | 0.277 |
R-HSA-72613 | Eukaryotic Translation Initiation | 5.285117e-01 | 0.277 |
R-HSA-9007101 | Rab regulation of trafficking | 5.326217e-01 | 0.274 |
R-HSA-70326 | Glucose metabolism | 5.326217e-01 | 0.274 |
R-HSA-2980736 | Peptide hormone metabolism | 5.326217e-01 | 0.274 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.336993e-01 | 0.273 |
R-HSA-70263 | Gluconeogenesis | 5.336993e-01 | 0.273 |
R-HSA-9031628 | NGF-stimulated transcription | 5.336993e-01 | 0.273 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 5.400201e-01 | 0.268 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.407684e-01 | 0.267 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.407684e-01 | 0.267 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.407684e-01 | 0.267 |
R-HSA-5658442 | Regulation of RAS by GAPs | 5.462555e-01 | 0.263 |
R-HSA-9006925 | Intracellular signaling by second messengers | 5.477968e-01 | 0.261 |
R-HSA-912446 | Meiotic recombination | 5.524069e-01 | 0.258 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.524069e-01 | 0.258 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 5.524069e-01 | 0.258 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.528041e-01 | 0.257 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.528041e-01 | 0.257 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.567664e-01 | 0.254 |
R-HSA-72187 | mRNA 3'-end processing | 5.584752e-01 | 0.253 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.584752e-01 | 0.253 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.584752e-01 | 0.253 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.584752e-01 | 0.253 |
R-HSA-6809371 | Formation of the cornified envelope | 5.607040e-01 | 0.251 |
R-HSA-9609690 | HCMV Early Events | 5.609931e-01 | 0.251 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.644616e-01 | 0.248 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.644616e-01 | 0.248 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.644616e-01 | 0.248 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 5.644616e-01 | 0.248 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.703672e-01 | 0.244 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.703672e-01 | 0.244 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.703672e-01 | 0.244 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.761931e-01 | 0.239 |
R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 5.761931e-01 | 0.239 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.796153e-01 | 0.237 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.800171e-01 | 0.237 |
R-HSA-209776 | Metabolism of amine-derived hormones | 5.819403e-01 | 0.235 |
R-HSA-5654736 | Signaling by FGFR1 | 5.819403e-01 | 0.235 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.819403e-01 | 0.235 |
R-HSA-75893 | TNF signaling | 5.819403e-01 | 0.235 |
R-HSA-5621480 | Dectin-2 family | 5.876100e-01 | 0.231 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.891779e-01 | 0.230 |
R-HSA-73894 | DNA Repair | 5.908352e-01 | 0.229 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.932031e-01 | 0.227 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 5.977896e-01 | 0.223 |
R-HSA-9909396 | Circadian clock | 5.987031e-01 | 0.223 |
R-HSA-194441 | Metabolism of non-coding RNA | 5.987207e-01 | 0.223 |
R-HSA-191859 | snRNP Assembly | 5.987207e-01 | 0.223 |
R-HSA-379724 | tRNA Aminoacylation | 6.041638e-01 | 0.219 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 6.041638e-01 | 0.219 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.041638e-01 | 0.219 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.041638e-01 | 0.219 |
R-HSA-351202 | Metabolism of polyamines | 6.041638e-01 | 0.219 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.041638e-01 | 0.219 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.041638e-01 | 0.219 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.041638e-01 | 0.219 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.041638e-01 | 0.219 |
R-HSA-1227986 | Signaling by ERBB2 | 6.041638e-01 | 0.219 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.095334e-01 | 0.215 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 6.095334e-01 | 0.215 |
R-HSA-450294 | MAP kinase activation | 6.095334e-01 | 0.215 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.095334e-01 | 0.215 |
R-HSA-112043 | PLC beta mediated events | 6.095334e-01 | 0.215 |
R-HSA-9793380 | Formation of paraxial mesoderm | 6.095334e-01 | 0.215 |
R-HSA-1268020 | Mitochondrial protein import | 6.148305e-01 | 0.211 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.148305e-01 | 0.211 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 6.148305e-01 | 0.211 |
R-HSA-9707616 | Heme signaling | 6.148305e-01 | 0.211 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.148305e-01 | 0.211 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 6.148305e-01 | 0.211 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.148305e-01 | 0.211 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.200560e-01 | 0.208 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.202970e-01 | 0.207 |
R-HSA-1257604 | PIP3 activates AKT signaling | 6.222526e-01 | 0.206 |
R-HSA-9948299 | Ribosome-associated quality control | 6.238081e-01 | 0.205 |
R-HSA-5358351 | Signaling by Hedgehog | 6.238081e-01 | 0.205 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.252110e-01 | 0.204 |
R-HSA-936837 | Ion transport by P-type ATPases | 6.252110e-01 | 0.204 |
R-HSA-6807070 | PTEN Regulation | 6.272942e-01 | 0.203 |
R-HSA-1234174 | Cellular response to hypoxia | 6.302963e-01 | 0.200 |
R-HSA-1632852 | Macroautophagy | 6.341914e-01 | 0.198 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.353130e-01 | 0.197 |
R-HSA-112040 | G-protein mediated events | 6.402619e-01 | 0.194 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 6.409890e-01 | 0.193 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.451439e-01 | 0.190 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 6.476872e-01 | 0.189 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.516895e-01 | 0.186 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.547110e-01 | 0.184 |
R-HSA-448424 | Interleukin-17 signaling | 6.547110e-01 | 0.184 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.547110e-01 | 0.184 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.547110e-01 | 0.184 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.547110e-01 | 0.184 |
R-HSA-9824439 | Bacterial Infection Pathways | 6.593947e-01 | 0.181 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.593978e-01 | 0.181 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.593978e-01 | 0.181 |
R-HSA-453276 | Regulation of mitotic cell cycle | 6.593978e-01 | 0.181 |
R-HSA-5632684 | Hedgehog 'on' state | 6.593978e-01 | 0.181 |
R-HSA-9638482 | Metal ion assimilation from the host | 6.593978e-01 | 0.181 |
R-HSA-975634 | Retinoid metabolism and transport | 6.593978e-01 | 0.181 |
R-HSA-166520 | Signaling by NTRKs | 6.607873e-01 | 0.180 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.640213e-01 | 0.178 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.640213e-01 | 0.178 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.685823e-01 | 0.175 |
R-HSA-4086398 | Ca2+ pathway | 6.685823e-01 | 0.175 |
R-HSA-1266738 | Developmental Biology | 6.723795e-01 | 0.172 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.734956e-01 | 0.172 |
R-HSA-8852135 | Protein ubiquitination | 6.775203e-01 | 0.169 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.797042e-01 | 0.168 |
R-HSA-5689603 | UCH proteinases | 6.818988e-01 | 0.166 |
R-HSA-1980143 | Signaling by NOTCH1 | 6.818988e-01 | 0.166 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.827724e-01 | 0.166 |
R-HSA-9612973 | Autophagy | 6.858166e-01 | 0.164 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 6.862182e-01 | 0.164 |
R-HSA-5619084 | ABC transporter disorders | 6.904792e-01 | 0.161 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.988292e-01 | 0.156 |
R-HSA-5654738 | Signaling by FGFR2 | 6.988292e-01 | 0.156 |
R-HSA-9833482 | PKR-mediated signaling | 6.988292e-01 | 0.156 |
R-HSA-977225 | Amyloid fiber formation | 7.029197e-01 | 0.153 |
R-HSA-6806667 | Metabolism of fat-soluble vitamins | 7.029197e-01 | 0.153 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.069549e-01 | 0.151 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.109356e-01 | 0.148 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.187361e-01 | 0.143 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.225574e-01 | 0.141 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.225574e-01 | 0.141 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.263270e-01 | 0.139 |
R-HSA-1614635 | Sulfur amino acid metabolism | 7.263270e-01 | 0.139 |
R-HSA-72306 | tRNA processing | 7.286662e-01 | 0.137 |
R-HSA-438064 | Post NMDA receptor activation events | 7.300457e-01 | 0.137 |
R-HSA-156902 | Peptide chain elongation | 7.337140e-01 | 0.134 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.339909e-01 | 0.134 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.392269e-01 | 0.131 |
R-HSA-112310 | Neurotransmitter release cycle | 7.409025e-01 | 0.130 |
R-HSA-9734767 | Developmental Cell Lineages | 7.414760e-01 | 0.130 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.444240e-01 | 0.128 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.444240e-01 | 0.128 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.478978e-01 | 0.126 |
R-HSA-156842 | Eukaryotic Translation Elongation | 7.513246e-01 | 0.124 |
R-HSA-168249 | Innate Immune System | 7.516593e-01 | 0.124 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.547051e-01 | 0.122 |
R-HSA-9837999 | Mitochondrial protein degradation | 7.580398e-01 | 0.120 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.613294e-01 | 0.118 |
R-HSA-72764 | Eukaryotic Translation Termination | 7.645744e-01 | 0.117 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.645744e-01 | 0.117 |
R-HSA-597592 | Post-translational protein modification | 7.663330e-01 | 0.116 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 7.690191e-01 | 0.114 |
R-HSA-8957275 | Post-translational protein phosphorylation | 7.740484e-01 | 0.111 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.740484e-01 | 0.111 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.740484e-01 | 0.111 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.740484e-01 | 0.111 |
R-HSA-190236 | Signaling by FGFR | 7.740484e-01 | 0.111 |
R-HSA-983712 | Ion channel transport | 7.757621e-01 | 0.110 |
R-HSA-70171 | Glycolysis | 7.801526e-01 | 0.108 |
R-HSA-382556 | ABC-family proteins mediated transport | 7.801526e-01 | 0.108 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.825115e-01 | 0.107 |
R-HSA-2408557 | Selenocysteine synthesis | 7.831428e-01 | 0.106 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 7.847216e-01 | 0.105 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.860926e-01 | 0.105 |
R-HSA-1483255 | PI Metabolism | 7.860926e-01 | 0.105 |
R-HSA-192823 | Viral mRNA Translation | 7.890024e-01 | 0.103 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.918728e-01 | 0.101 |
R-HSA-5673001 | RAF/MAP kinase cascade | 7.928891e-01 | 0.101 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 7.947043e-01 | 0.100 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.947043e-01 | 0.100 |
R-HSA-9833110 | RSV-host interactions | 7.947043e-01 | 0.100 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.974975e-01 | 0.098 |
R-HSA-389948 | Co-inhibition by PD-1 | 7.996484e-01 | 0.097 |
R-HSA-418346 | Platelet homeostasis | 8.002528e-01 | 0.097 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 8.029709e-01 | 0.095 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.051941e-01 | 0.094 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.056521e-01 | 0.094 |
R-HSA-2672351 | Stimuli-sensing channels | 8.056521e-01 | 0.094 |
R-HSA-376176 | Signaling by ROBO receptors | 8.057613e-01 | 0.094 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 8.082970e-01 | 0.092 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 8.109060e-01 | 0.091 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 8.109060e-01 | 0.091 |
R-HSA-6803157 | Antimicrobial peptides | 8.134797e-01 | 0.090 |
R-HSA-6805567 | Keratinization | 8.136547e-01 | 0.090 |
R-HSA-2871796 | FCERI mediated MAPK activation | 8.160186e-01 | 0.088 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 8.185230e-01 | 0.087 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.234305e-01 | 0.084 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.249601e-01 | 0.084 |
R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.282059e-01 | 0.082 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 8.282059e-01 | 0.082 |
R-HSA-373760 | L1CAM interactions | 8.305451e-01 | 0.081 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.351290e-01 | 0.078 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.417743e-01 | 0.075 |
R-HSA-112315 | Transmission across Chemical Synapses | 8.470533e-01 | 0.072 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.522625e-01 | 0.069 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.522625e-01 | 0.069 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.522625e-01 | 0.069 |
R-HSA-194138 | Signaling by VEGF | 8.522625e-01 | 0.069 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.542755e-01 | 0.068 |
R-HSA-446203 | Asparagine N-linked glycosylation | 8.546911e-01 | 0.068 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.620584e-01 | 0.064 |
R-HSA-72766 | Translation | 8.628762e-01 | 0.064 |
R-HSA-5683057 | MAPK family signaling cascades | 8.775045e-01 | 0.057 |
R-HSA-5619115 | Disorders of transmembrane transporters | 8.794489e-01 | 0.056 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.830103e-01 | 0.054 |
R-HSA-9664407 | Parasite infection | 8.830103e-01 | 0.054 |
R-HSA-9664417 | Leishmania phagocytosis | 8.830103e-01 | 0.054 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.846061e-01 | 0.053 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.899255e-01 | 0.051 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.906882e-01 | 0.050 |
R-HSA-392499 | Metabolism of proteins | 8.943094e-01 | 0.049 |
R-HSA-2187338 | Visual phototransduction | 8.951860e-01 | 0.048 |
R-HSA-9758941 | Gastrulation | 8.980274e-01 | 0.047 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 9.007921e-01 | 0.045 |
R-HSA-112316 | Neuronal System | 9.016219e-01 | 0.045 |
R-HSA-9609507 | Protein localization | 9.034822e-01 | 0.044 |
R-HSA-9711097 | Cellular response to starvation | 9.098939e-01 | 0.041 |
R-HSA-9824443 | Parasitic Infection Pathways | 9.170198e-01 | 0.038 |
R-HSA-9658195 | Leishmania infection | 9.170198e-01 | 0.038 |
R-HSA-5619102 | SLC transporter disorders | 9.203852e-01 | 0.036 |
R-HSA-9664433 | Leishmania parasite growth and survival | 9.276965e-01 | 0.033 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.276965e-01 | 0.033 |
R-HSA-9640148 | Infection with Enterobacteria | 9.521744e-01 | 0.021 |
R-HSA-1474244 | Extracellular matrix organization | 9.528692e-01 | 0.021 |
R-HSA-388396 | GPCR downstream signalling | 9.615858e-01 | 0.017 |
R-HSA-8951664 | Neddylation | 9.632038e-01 | 0.016 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.675046e-01 | 0.014 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 9.678457e-01 | 0.014 |
R-HSA-416476 | G alpha (q) signalling events | 9.796942e-01 | 0.009 |
R-HSA-9711123 | Cellular response to chemical stress | 9.807883e-01 | 0.008 |
R-HSA-418594 | G alpha (i) signalling events | 9.808705e-01 | 0.008 |
R-HSA-372790 | Signaling by GPCR | 9.813413e-01 | 0.008 |
R-HSA-1483257 | Phospholipid metabolism | 9.867855e-01 | 0.006 |
R-HSA-382551 | Transport of small molecules | 9.981133e-01 | 0.001 |
R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 1.000000e+00 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
FAM20C |
0.831 | 0.433 | 2 | 0.876 |
COT |
0.830 | 0.085 | 2 | 0.743 |
PIM3 |
0.825 | 0.123 | -3 | 0.901 |
PIM1 |
0.823 | 0.168 | -3 | 0.874 |
RSK2 |
0.823 | 0.158 | -3 | 0.871 |
CAMK1B |
0.821 | 0.127 | -3 | 0.904 |
PRKD2 |
0.820 | 0.158 | -3 | 0.875 |
PRKD1 |
0.820 | 0.131 | -3 | 0.887 |
ATM |
0.819 | 0.263 | 1 | 0.879 |
PKN3 |
0.819 | 0.090 | -3 | 0.886 |
P90RSK |
0.818 | 0.143 | -3 | 0.867 |
SKMLCK |
0.818 | 0.176 | -2 | 0.836 |
ATR |
0.818 | 0.190 | 1 | 0.887 |
CAMK2B |
0.818 | 0.203 | 2 | 0.758 |
CDKL1 |
0.818 | 0.128 | -3 | 0.872 |
CLK3 |
0.818 | 0.108 | 1 | 0.760 |
CAMLCK |
0.817 | 0.152 | -2 | 0.839 |
CDC7 |
0.816 | 0.028 | 1 | 0.859 |
MAPKAPK3 |
0.816 | 0.140 | -3 | 0.874 |
DAPK2 |
0.815 | 0.168 | -3 | 0.894 |
TGFBR2 |
0.815 | 0.080 | -2 | 0.827 |
NDR1 |
0.815 | 0.071 | -3 | 0.901 |
RIPK3 |
0.815 | 0.098 | 3 | 0.773 |
DSTYK |
0.815 | 0.058 | 2 | 0.761 |
NDR2 |
0.814 | 0.050 | -3 | 0.897 |
RSK3 |
0.814 | 0.127 | -3 | 0.871 |
CAMK2D |
0.814 | 0.141 | -3 | 0.879 |
P70S6KB |
0.814 | 0.118 | -3 | 0.881 |
MAPKAPK2 |
0.814 | 0.157 | -3 | 0.856 |
LATS2 |
0.813 | 0.071 | -5 | 0.680 |
PRKD3 |
0.813 | 0.154 | -3 | 0.853 |
PKCD |
0.813 | 0.066 | 2 | 0.645 |
CDKL5 |
0.813 | 0.113 | -3 | 0.868 |
PRPK |
0.813 | -0.062 | -1 | 0.721 |
CAMK2G |
0.812 | 0.040 | 2 | 0.723 |
BMPR2 |
0.811 | 0.030 | -2 | 0.857 |
WNK1 |
0.811 | 0.040 | -2 | 0.817 |
NLK |
0.811 | 0.037 | 1 | 0.712 |
NIK |
0.810 | 0.045 | -3 | 0.896 |
TSSK2 |
0.810 | 0.071 | -5 | 0.762 |
CAMK4 |
0.809 | 0.084 | -3 | 0.882 |
MOS |
0.809 | -0.016 | 1 | 0.841 |
NUAK2 |
0.809 | 0.055 | -3 | 0.900 |
MYLK4 |
0.808 | 0.158 | -2 | 0.791 |
PKN2 |
0.808 | 0.045 | -3 | 0.881 |
RSK4 |
0.808 | 0.136 | -3 | 0.852 |
RAF1 |
0.808 | -0.065 | 1 | 0.794 |
PKACG |
0.808 | 0.087 | -2 | 0.779 |
TSSK1 |
0.808 | 0.057 | -3 | 0.912 |
MSK1 |
0.808 | 0.150 | -3 | 0.847 |
MELK |
0.807 | 0.093 | -3 | 0.884 |
PIM2 |
0.807 | 0.151 | -3 | 0.852 |
GCN2 |
0.807 | -0.089 | 2 | 0.647 |
AMPKA1 |
0.806 | 0.025 | -3 | 0.901 |
LATS1 |
0.806 | 0.120 | -3 | 0.904 |
WNK3 |
0.806 | -0.010 | 1 | 0.770 |
AURB |
0.806 | 0.101 | -2 | 0.699 |
ICK |
0.806 | 0.070 | -3 | 0.892 |
MSK2 |
0.806 | 0.113 | -3 | 0.837 |
ERK5 |
0.805 | 0.042 | 1 | 0.729 |
ULK2 |
0.805 | -0.126 | 2 | 0.641 |
SMG1 |
0.805 | 0.297 | 1 | 0.863 |
NUAK1 |
0.805 | 0.071 | -3 | 0.891 |
BMPR1B |
0.805 | 0.127 | 1 | 0.802 |
TBK1 |
0.804 | -0.065 | 1 | 0.676 |
CAMK2A |
0.804 | 0.113 | 2 | 0.711 |
PDHK4 |
0.804 | -0.113 | 1 | 0.784 |
MNK2 |
0.804 | 0.067 | -2 | 0.791 |
SRPK1 |
0.804 | 0.099 | -3 | 0.842 |
MST4 |
0.804 | -0.007 | 2 | 0.682 |
PAK1 |
0.803 | 0.059 | -2 | 0.786 |
PAK3 |
0.803 | 0.055 | -2 | 0.786 |
AURC |
0.803 | 0.076 | -2 | 0.699 |
AMPKA2 |
0.802 | 0.045 | -3 | 0.893 |
ALK2 |
0.802 | 0.169 | -2 | 0.842 |
MLK1 |
0.802 | -0.058 | 2 | 0.668 |
TGFBR1 |
0.802 | 0.113 | -2 | 0.837 |
PKG2 |
0.802 | 0.109 | -2 | 0.721 |
DNAPK |
0.802 | 0.209 | 1 | 0.787 |
CHK1 |
0.802 | 0.083 | -3 | 0.907 |
IKKB |
0.802 | -0.059 | -2 | 0.709 |
PKACB |
0.802 | 0.122 | -2 | 0.723 |
SRPK2 |
0.801 | 0.115 | -3 | 0.796 |
NIM1 |
0.801 | 0.008 | 3 | 0.737 |
IRE2 |
0.801 | 0.001 | 2 | 0.620 |
CLK1 |
0.801 | 0.115 | -3 | 0.854 |
MARK4 |
0.801 | -0.014 | 4 | 0.756 |
ALK4 |
0.800 | 0.077 | -2 | 0.847 |
NEK7 |
0.800 | -0.093 | -3 | 0.786 |
HUNK |
0.800 | -0.089 | 2 | 0.631 |
SGK3 |
0.800 | 0.104 | -3 | 0.854 |
CAMK1D |
0.800 | 0.157 | -3 | 0.825 |
SMMLCK |
0.800 | 0.153 | -3 | 0.879 |
AKT2 |
0.799 | 0.131 | -3 | 0.810 |
CLK4 |
0.799 | 0.108 | -3 | 0.861 |
DAPK3 |
0.799 | 0.189 | -3 | 0.880 |
PKCB |
0.799 | 0.023 | 2 | 0.597 |
GRK6 |
0.799 | -0.005 | 1 | 0.815 |
RIPK1 |
0.798 | -0.035 | 1 | 0.771 |
MNK1 |
0.797 | 0.057 | -2 | 0.804 |
NEK9 |
0.797 | -0.085 | 2 | 0.668 |
PAK2 |
0.797 | 0.050 | -2 | 0.772 |
IKKE |
0.796 | -0.095 | 1 | 0.669 |
PAK6 |
0.796 | 0.074 | -2 | 0.707 |
ANKRD3 |
0.796 | -0.064 | 1 | 0.812 |
PKR |
0.796 | 0.004 | 1 | 0.794 |
PLK1 |
0.796 | -0.021 | -2 | 0.810 |
CAMK1G |
0.796 | 0.081 | -3 | 0.855 |
PDHK1 |
0.795 | -0.195 | 1 | 0.774 |
PKCH |
0.795 | 0.015 | 2 | 0.583 |
PRKX |
0.795 | 0.137 | -3 | 0.804 |
ACVR2A |
0.795 | 0.070 | -2 | 0.806 |
SRPK3 |
0.795 | 0.089 | -3 | 0.817 |
PHKG1 |
0.795 | 0.022 | -3 | 0.886 |
BMPR1A |
0.795 | 0.134 | 1 | 0.793 |
PKACA |
0.795 | 0.131 | -2 | 0.681 |
GRK1 |
0.794 | 0.021 | -2 | 0.780 |
MLK2 |
0.794 | -0.094 | 2 | 0.673 |
DCAMKL1 |
0.794 | 0.072 | -3 | 0.883 |
ULK1 |
0.794 | -0.140 | -3 | 0.772 |
AURA |
0.794 | 0.080 | -2 | 0.674 |
MTOR |
0.794 | -0.186 | 1 | 0.696 |
MAPKAPK5 |
0.794 | 0.100 | -3 | 0.815 |
AKT1 |
0.794 | 0.130 | -3 | 0.824 |
NEK6 |
0.794 | -0.113 | -2 | 0.818 |
ACVR2B |
0.794 | 0.080 | -2 | 0.818 |
SIK |
0.794 | 0.053 | -3 | 0.857 |
DLK |
0.793 | -0.116 | 1 | 0.787 |
PKCG |
0.793 | -0.007 | 2 | 0.587 |
IRE1 |
0.793 | -0.077 | 1 | 0.751 |
PKCA |
0.793 | 0.001 | 2 | 0.586 |
P70S6K |
0.792 | 0.107 | -3 | 0.820 |
QIK |
0.792 | -0.019 | -3 | 0.864 |
CLK2 |
0.792 | 0.121 | -3 | 0.862 |
MASTL |
0.792 | -0.163 | -2 | 0.773 |
CHAK2 |
0.791 | -0.102 | -1 | 0.697 |
GRK5 |
0.791 | -0.146 | -3 | 0.801 |
MLK3 |
0.790 | -0.047 | 2 | 0.605 |
DCAMKL2 |
0.790 | 0.057 | -3 | 0.897 |
MLK4 |
0.790 | -0.055 | 2 | 0.605 |
IKKA |
0.790 | -0.055 | -2 | 0.697 |
QSK |
0.789 | 0.003 | 4 | 0.731 |
PLK3 |
0.789 | -0.000 | 2 | 0.658 |
CAMK1A |
0.789 | 0.144 | -3 | 0.798 |
DAPK1 |
0.789 | 0.148 | -3 | 0.858 |
BRSK1 |
0.788 | 0.019 | -3 | 0.882 |
MEK1 |
0.788 | -0.080 | 2 | 0.686 |
HIPK4 |
0.788 | -0.014 | 1 | 0.679 |
PKCZ |
0.787 | -0.043 | 2 | 0.623 |
SNRK |
0.787 | -0.032 | 2 | 0.548 |
GRK4 |
0.787 | -0.082 | -2 | 0.806 |
IRAK4 |
0.787 | -0.028 | 1 | 0.769 |
PKCT |
0.787 | 0.023 | 2 | 0.594 |
TTBK2 |
0.787 | -0.126 | 2 | 0.549 |
MARK2 |
0.787 | -0.000 | 4 | 0.647 |
DRAK1 |
0.786 | -0.021 | 1 | 0.748 |
BRAF |
0.786 | -0.027 | -4 | 0.748 |
NEK2 |
0.786 | -0.094 | 2 | 0.637 |
BCKDK |
0.786 | -0.148 | -1 | 0.652 |
CHK2 |
0.786 | 0.138 | -3 | 0.775 |
SSTK |
0.786 | 0.012 | 4 | 0.727 |
CHAK1 |
0.785 | -0.094 | 2 | 0.588 |
PHKG2 |
0.785 | 0.033 | -3 | 0.871 |
MRCKB |
0.784 | 0.135 | -3 | 0.842 |
VRK2 |
0.784 | -0.164 | 1 | 0.807 |
MRCKA |
0.784 | 0.128 | -3 | 0.859 |
MARK1 |
0.784 | -0.006 | 4 | 0.711 |
BRSK2 |
0.783 | -0.034 | -3 | 0.882 |
HRI |
0.783 | -0.080 | -2 | 0.830 |
WNK4 |
0.783 | -0.054 | -2 | 0.787 |
PERK |
0.782 | -0.074 | -2 | 0.823 |
IRAK1 |
0.781 | -0.044 | -1 | 0.682 |
AKT3 |
0.781 | 0.121 | -3 | 0.764 |
PLK4 |
0.781 | -0.086 | 2 | 0.503 |
SGK1 |
0.781 | 0.132 | -3 | 0.753 |
PKN1 |
0.781 | 0.077 | -3 | 0.829 |
NEK5 |
0.781 | -0.050 | 1 | 0.803 |
DYRK2 |
0.780 | -0.010 | 1 | 0.568 |
ROCK2 |
0.780 | 0.122 | -3 | 0.871 |
DYRK1A |
0.780 | 0.039 | 1 | 0.607 |
YSK4 |
0.780 | -0.145 | 1 | 0.716 |
MARK3 |
0.780 | -0.032 | 4 | 0.680 |
PAK5 |
0.779 | 0.051 | -2 | 0.664 |
DMPK1 |
0.779 | 0.148 | -3 | 0.861 |
CDK7 |
0.778 | -0.061 | 1 | 0.547 |
TLK2 |
0.778 | -0.077 | 1 | 0.797 |
PKCI |
0.778 | -0.007 | 2 | 0.593 |
P38A |
0.778 | -0.027 | 1 | 0.579 |
HIPK1 |
0.777 | 0.015 | 1 | 0.579 |
CDK8 |
0.777 | -0.070 | 1 | 0.539 |
PAK4 |
0.777 | 0.053 | -2 | 0.675 |
GRK7 |
0.777 | -0.035 | 1 | 0.733 |
PKCE |
0.777 | 0.040 | 2 | 0.569 |
PKG1 |
0.776 | 0.112 | -2 | 0.647 |
CDK5 |
0.776 | -0.056 | 1 | 0.570 |
PASK |
0.775 | 0.001 | -3 | 0.885 |
MEKK2 |
0.775 | -0.105 | 2 | 0.660 |
MEKK1 |
0.775 | -0.138 | 1 | 0.765 |
TLK1 |
0.775 | -0.062 | -2 | 0.832 |
GRK2 |
0.775 | -0.056 | -2 | 0.706 |
ZAK |
0.775 | -0.144 | 1 | 0.736 |
CDK14 |
0.774 | -0.003 | 1 | 0.509 |
MEK5 |
0.774 | -0.183 | 2 | 0.669 |
JNK2 |
0.774 | -0.031 | 1 | 0.481 |
MEKK3 |
0.774 | -0.135 | 1 | 0.744 |
CDK18 |
0.773 | -0.038 | 1 | 0.470 |
HIPK3 |
0.773 | 0.000 | 1 | 0.570 |
ERK2 |
0.773 | -0.052 | 1 | 0.534 |
MST3 |
0.772 | -0.072 | 2 | 0.646 |
SBK |
0.772 | 0.124 | -3 | 0.731 |
CDK2 |
0.772 | -0.058 | 1 | 0.588 |
DYRK3 |
0.772 | 0.048 | 1 | 0.583 |
ROCK1 |
0.772 | 0.121 | -3 | 0.853 |
KIS |
0.771 | -0.064 | 1 | 0.568 |
NEK8 |
0.771 | -0.095 | 2 | 0.650 |
TAO2 |
0.771 | -0.064 | 2 | 0.686 |
JNK3 |
0.770 | -0.058 | 1 | 0.522 |
GAK |
0.770 | -0.029 | 1 | 0.780 |
CRIK |
0.770 | 0.136 | -3 | 0.827 |
CDK19 |
0.770 | -0.073 | 1 | 0.498 |
EEF2K |
0.769 | -0.040 | 3 | 0.751 |
P38B |
0.769 | -0.036 | 1 | 0.512 |
CAMKK1 |
0.769 | -0.108 | -2 | 0.722 |
TTBK1 |
0.768 | -0.089 | 2 | 0.481 |
CDK16 |
0.768 | -0.022 | 1 | 0.434 |
BUB1 |
0.767 | 0.056 | -5 | 0.738 |
NEK4 |
0.767 | -0.080 | 1 | 0.744 |
PINK1 |
0.767 | -0.142 | 1 | 0.727 |
TAO3 |
0.767 | -0.114 | 1 | 0.730 |
ERK1 |
0.767 | -0.056 | 1 | 0.493 |
DYRK4 |
0.767 | 0.003 | 1 | 0.488 |
MPSK1 |
0.767 | -0.064 | 1 | 0.704 |
HIPK2 |
0.767 | -0.014 | 1 | 0.467 |
CDK17 |
0.767 | -0.055 | 1 | 0.416 |
TTK |
0.766 | 0.078 | -2 | 0.829 |
PDK1 |
0.766 | -0.054 | 1 | 0.732 |
MEKK6 |
0.766 | -0.096 | 1 | 0.753 |
ERK7 |
0.766 | -0.022 | 2 | 0.442 |
CDK1 |
0.765 | -0.073 | 1 | 0.501 |
PLK2 |
0.765 | 0.011 | -3 | 0.796 |
MAK |
0.765 | 0.067 | -2 | 0.697 |
DYRK1B |
0.765 | -0.011 | 1 | 0.513 |
CDK13 |
0.765 | -0.095 | 1 | 0.513 |
LOK |
0.764 | -0.047 | -2 | 0.755 |
NEK1 |
0.764 | -0.063 | 1 | 0.759 |
TAK1 |
0.764 | -0.036 | 1 | 0.793 |
TNIK |
0.764 | -0.048 | 3 | 0.765 |
MOK |
0.764 | 0.058 | 1 | 0.615 |
CAMKK2 |
0.763 | -0.136 | -2 | 0.720 |
HGK |
0.763 | -0.079 | 3 | 0.772 |
NEK11 |
0.763 | -0.173 | 1 | 0.730 |
VRK1 |
0.762 | -0.088 | 2 | 0.681 |
CDK10 |
0.762 | -0.032 | 1 | 0.496 |
MINK |
0.762 | -0.080 | 1 | 0.732 |
RIPK2 |
0.761 | -0.093 | 1 | 0.692 |
MST2 |
0.761 | -0.119 | 1 | 0.759 |
CK2A2 |
0.761 | 0.005 | 1 | 0.706 |
CDK9 |
0.760 | -0.099 | 1 | 0.519 |
CDK3 |
0.760 | -0.039 | 1 | 0.438 |
P38G |
0.760 | -0.070 | 1 | 0.408 |
GCK |
0.760 | -0.101 | 1 | 0.732 |
MAP3K15 |
0.759 | -0.135 | 1 | 0.711 |
GSK3B |
0.759 | -0.051 | 4 | 0.407 |
CDK12 |
0.759 | -0.091 | 1 | 0.483 |
LKB1 |
0.759 | -0.147 | -3 | 0.786 |
LRRK2 |
0.758 | -0.140 | 2 | 0.671 |
PRP4 |
0.758 | -0.097 | -3 | 0.664 |
MEK2 |
0.757 | -0.122 | 2 | 0.657 |
GRK3 |
0.757 | -0.067 | -2 | 0.671 |
BIKE |
0.757 | 0.041 | 1 | 0.656 |
HPK1 |
0.756 | -0.073 | 1 | 0.710 |
CK1E |
0.755 | -0.087 | -3 | 0.449 |
KHS1 |
0.755 | -0.067 | 1 | 0.710 |
MST1 |
0.755 | -0.135 | 1 | 0.735 |
KHS2 |
0.754 | -0.042 | 1 | 0.719 |
PBK |
0.753 | -0.042 | 1 | 0.712 |
CDK4 |
0.753 | -0.049 | 1 | 0.470 |
YSK1 |
0.753 | -0.114 | 2 | 0.639 |
SLK |
0.752 | -0.102 | -2 | 0.697 |
P38D |
0.751 | -0.054 | 1 | 0.452 |
CDK6 |
0.751 | -0.063 | 1 | 0.487 |
STK33 |
0.751 | -0.139 | 2 | 0.476 |
GSK3A |
0.750 | -0.065 | 4 | 0.424 |
NEK3 |
0.749 | -0.122 | 1 | 0.705 |
CK2A1 |
0.749 | -0.012 | 1 | 0.681 |
ALPHAK3 |
0.748 | 0.021 | -1 | 0.622 |
HASPIN |
0.747 | -0.036 | -1 | 0.584 |
CK1D |
0.747 | -0.078 | -3 | 0.391 |
CK1A2 |
0.744 | -0.092 | -3 | 0.399 |
JNK1 |
0.744 | -0.073 | 1 | 0.470 |
AAK1 |
0.743 | 0.053 | 1 | 0.551 |
OSR1 |
0.742 | -0.117 | 2 | 0.642 |
CK1G1 |
0.741 | -0.119 | -3 | 0.455 |
MYO3B |
0.741 | -0.084 | 2 | 0.650 |
MYO3A |
0.740 | -0.084 | 1 | 0.714 |
ASK1 |
0.739 | -0.133 | 1 | 0.698 |
TAO1 |
0.736 | -0.108 | 1 | 0.659 |
YANK3 |
0.734 | -0.075 | 2 | 0.317 |
PDHK3_TYR |
0.733 | 0.032 | 4 | 0.867 |
TNK2 |
0.733 | 0.210 | 3 | 0.806 |
EPHA6 |
0.732 | 0.121 | -1 | 0.691 |
TYRO3 |
0.731 | 0.138 | 3 | 0.772 |
YES1 |
0.730 | 0.144 | -1 | 0.761 |
EPHB4 |
0.729 | 0.140 | -1 | 0.717 |
TEC |
0.729 | 0.194 | -1 | 0.742 |
SRMS |
0.729 | 0.209 | 1 | 0.853 |
STLK3 |
0.729 | -0.136 | 1 | 0.701 |
AXL |
0.728 | 0.195 | 3 | 0.794 |
BLK |
0.727 | 0.183 | -1 | 0.729 |
MERTK |
0.727 | 0.215 | 3 | 0.768 |
TXK |
0.727 | 0.153 | 1 | 0.828 |
ROS1 |
0.725 | 0.057 | 3 | 0.767 |
ABL2 |
0.725 | 0.102 | -1 | 0.716 |
TESK1_TYR |
0.725 | -0.097 | 3 | 0.778 |
FER |
0.723 | 0.095 | 1 | 0.872 |
HCK |
0.723 | 0.138 | -1 | 0.741 |
RET |
0.723 | 0.011 | 1 | 0.751 |
LCK |
0.723 | 0.136 | -1 | 0.721 |
INSRR |
0.723 | 0.079 | 3 | 0.757 |
EPHB1 |
0.722 | 0.128 | 1 | 0.852 |
PDHK4_TYR |
0.722 | -0.049 | 2 | 0.732 |
PINK1_TYR |
0.721 | -0.121 | 1 | 0.776 |
ITK |
0.721 | 0.083 | -1 | 0.737 |
BMX |
0.721 | 0.113 | -1 | 0.688 |
MAP2K6_TYR |
0.721 | -0.075 | -1 | 0.716 |
EPHA1 |
0.721 | 0.182 | 3 | 0.789 |
LIMK2_TYR |
0.721 | -0.050 | -3 | 0.882 |
EPHB2 |
0.721 | 0.130 | -1 | 0.706 |
LTK |
0.720 | 0.111 | 3 | 0.750 |
DDR1 |
0.720 | 0.025 | 4 | 0.776 |
MST1R |
0.720 | 0.024 | 3 | 0.794 |
MAP2K4_TYR |
0.720 | -0.131 | -1 | 0.731 |
TYK2 |
0.720 | -0.036 | 1 | 0.754 |
MAP2K7_TYR |
0.720 | -0.195 | 2 | 0.706 |
CSF1R |
0.719 | 0.046 | 3 | 0.790 |
PDGFRB |
0.719 | 0.026 | 3 | 0.800 |
EPHB3 |
0.719 | 0.116 | -1 | 0.709 |
EPHA4 |
0.718 | 0.077 | 2 | 0.653 |
TEK |
0.718 | 0.094 | 3 | 0.749 |
PKMYT1_TYR |
0.718 | -0.176 | 3 | 0.773 |
BTK |
0.717 | 0.131 | -1 | 0.759 |
EPHA7 |
0.717 | 0.131 | 2 | 0.651 |
ABL1 |
0.717 | 0.052 | -1 | 0.719 |
BMPR2_TYR |
0.717 | -0.087 | -1 | 0.681 |
DDR2 |
0.716 | 0.107 | 3 | 0.781 |
ALK |
0.716 | 0.058 | 3 | 0.744 |
FLT3 |
0.715 | 0.024 | 3 | 0.777 |
PDHK1_TYR |
0.715 | -0.120 | -1 | 0.722 |
FGFR2 |
0.715 | 0.033 | 3 | 0.790 |
JAK2 |
0.715 | -0.038 | 1 | 0.746 |
TNK1 |
0.714 | -0.020 | 3 | 0.742 |
EPHA5 |
0.714 | 0.141 | 2 | 0.661 |
PTK2B |
0.714 | 0.103 | -1 | 0.738 |
LIMK1_TYR |
0.713 | -0.170 | 2 | 0.699 |
FYN |
0.712 | 0.087 | -1 | 0.684 |
FGR |
0.712 | -0.041 | 1 | 0.824 |
JAK3 |
0.712 | -0.059 | 1 | 0.742 |
LYN |
0.711 | 0.110 | 3 | 0.723 |
KDR |
0.711 | 0.003 | 3 | 0.787 |
JAK1 |
0.710 | 0.009 | 1 | 0.688 |
EPHA3 |
0.710 | 0.049 | 2 | 0.628 |
FRK |
0.709 | 0.082 | -1 | 0.766 |
KIT |
0.709 | -0.012 | 3 | 0.790 |
FGFR1 |
0.709 | -0.016 | 3 | 0.783 |
PDGFRA |
0.708 | -0.035 | 3 | 0.797 |
NTRK1 |
0.707 | 0.005 | -1 | 0.678 |
NTRK2 |
0.706 | 0.009 | 3 | 0.774 |
MET |
0.705 | -0.023 | 3 | 0.785 |
FGFR3 |
0.703 | 0.003 | 3 | 0.779 |
NEK10_TYR |
0.703 | -0.089 | 1 | 0.605 |
INSR |
0.703 | -0.022 | 3 | 0.729 |
TNNI3K_TYR |
0.702 | -0.107 | 1 | 0.769 |
EPHA8 |
0.702 | 0.042 | -1 | 0.659 |
YANK2 |
0.701 | -0.100 | 2 | 0.348 |
SRC |
0.700 | 0.029 | -1 | 0.699 |
PTK6 |
0.700 | -0.082 | -1 | 0.662 |
WEE1_TYR |
0.700 | -0.070 | -1 | 0.665 |
FLT4 |
0.698 | -0.066 | 3 | 0.752 |
NTRK3 |
0.698 | -0.016 | -1 | 0.632 |
ERBB2 |
0.698 | -0.062 | 1 | 0.717 |
CK1A |
0.698 | -0.124 | -3 | 0.303 |
MATK |
0.696 | -0.054 | -1 | 0.629 |
CK1G3 |
0.694 | -0.099 | -3 | 0.256 |
EPHA2 |
0.693 | 0.046 | -1 | 0.628 |
EGFR |
0.693 | -0.018 | 1 | 0.637 |
CSK |
0.691 | -0.057 | 2 | 0.645 |
FGFR4 |
0.689 | -0.011 | -1 | 0.638 |
FLT1 |
0.689 | -0.129 | -1 | 0.633 |
IGF1R |
0.689 | -0.039 | 3 | 0.675 |
PTK2 |
0.689 | -0.015 | -1 | 0.576 |
FES |
0.683 | 0.002 | -1 | 0.648 |
ERBB4 |
0.683 | -0.008 | 1 | 0.671 |
MUSK |
0.682 | -0.091 | 1 | 0.626 |
SYK |
0.682 | -0.024 | -1 | 0.576 |
CK1G2 |
0.670 | -0.108 | -3 | 0.361 |
ZAP70 |
0.652 | -0.093 | -1 | 0.524 |