Motif 681 (n=109)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NC98 | CCDC88B | S1253 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| A6NMD2 | GOLGA8J | S260 | ochoa | Golgin subfamily A member 8J | None |
| F6TDL0 | P3R3URF-PIK3R3 | Y245 | ochoa | Phosphatidylinositol 3-kinase regulatory subunit gamma (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (p55PIK) | Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. {ECO:0000256|ARBA:ARBA00057933}. |
| H3BQL2 | GOLGA8T | S260 | ochoa | Golgin subfamily A member 8T | None |
| H3BSY2 | GOLGA8M | S260 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S260 | ochoa | Golgin subfamily A member 8R | None |
| O15155 | BET1 | S50 | ochoa|psp | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | Required for vesicular transport from the ER to the Golgi complex (PubMed:34779586). Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). {ECO:0000250|UniProtKB:Q62896, ECO:0000269|PubMed:34779586}. |
| O15344 | MID1 | S213 | ochoa | E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) | Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}. |
| O75154 | RAB11FIP3 | S538 | ochoa|psp | Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148) | Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867). {ECO:0000250|UniProtKB:Q8CHD8, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:17628206, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19327867, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26258637, ECO:0000269|PubMed:31204173}. |
| O75379 | VAMP4 | S92 | ochoa | Vesicle-associated membrane protein 4 (VAMP-4) | Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. |
| O75955 | FLOT1 | Y348 | ochoa | Flotillin-1 | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. |
| P02545 | LMNA | S303 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P04844 | RPN2 | S516 | ochoa | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2) | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. {ECO:0000250|UniProtKB:F1PCT7, ECO:0000269|PubMed:31831667}. |
| P07339 | CTSD | S350 | ochoa | Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}. |
| P08670 | VIM | T327 | ochoa|psp | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P0CJ92 | GOLGA8H | S260 | ochoa | Golgin subfamily A member 8H | None |
| P10275 | AR | S792 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P10809 | HSPD1 | S398 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11055 | MYH3 | S1479 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | T997 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1306 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1482 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | T1302 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1478 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | T1304 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | S1480 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1481 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P15924 | DSP | S1658 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P18846 | ATF1 | S72 | ochoa | Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36) | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}. |
| P20700 | LMNB1 | S304 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P22415 | USF1 | S262 | psp | Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1) | Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. |
| P27986 | PIK3R1 | Y467 | ochoa|psp | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}. |
| P35240 | NF2 | S518 | ochoa|psp | Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) | Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}. |
| P35579 | MYH9 | S1328 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S998 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35749 | MYH11 | S1756 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P52630 | STAT2 | S734 | psp | Signal transducer and activator of transcription 2 (p113) | Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}. |
| P52732 | KIF11 | T458 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P80303 | NUCB2 | S89 | ochoa | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}. |
| Q00987 | MDM2 | S262 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q01082 | SPTBN1 | S1447 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01082 | SPTBN1 | S2042 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01658 | DR1 | S105 | ochoa | Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}. |
| Q02818 | NUCB1 | S86 | ochoa | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q02818 | NUCB1 | S369 | ochoa | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q03252 | LMNB2 | S318 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q06323 | PSME1 | S55 | ochoa | Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha) | Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. |
| Q08378 | GOLGA3 | S467 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q12873 | CHD3 | S1819 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q13200 | PSMD2 | S46 | ochoa | 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. |
| Q13506 | NAB1 | S356 | ochoa | NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. {ECO:0000250}. |
| Q14191 | WRN | S258 | ochoa | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| Q14739 | LBR | S156 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q14789 | GOLGB1 | S1753 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14980 | NUMA1 | S1280 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14980 | NUMA1 | T1534 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15390 | MTFR1 | S124 | ochoa | Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) | May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}. |
| Q5JR59 | MTUS2 | S1302 | ochoa | Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) | Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. {ECO:0000269|PubMed:19543227}. |
| Q5JTW2 | CEP78 | S453 | ochoa | Centrosomal protein of 78 kDa (Cep78) | Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis (PubMed:27246242, PubMed:27588451, PubMed:28242748, PubMed:34259627). Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). Involved in cilium biogenesis and controls cilium length (PubMed:27588451). Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins (PubMed:28242748, PubMed:34259627). Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (By similarity). {ECO:0000250|UniProtKB:Q6IRU7, ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27588451, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}. |
| Q5M775 | SPECC1 | S437 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T3I0 | GPATCH4 | S91 | ochoa | G patch domain-containing protein 4 | None |
| Q5TZA2 | CROCC | S1900 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q674X7 | KAZN | S20 | ochoa | Kazrin | Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}. |
| Q6IBW4 | NCAPH2 | S492 | ochoa|psp | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6WCQ1 | MPRIP | S662 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZUJ8 | PIK3AP1 | S426 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q7Z2W4 | ZC3HAV1 | S114 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q8IX03 | WWC1 | T1006 | psp | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IX12 | CCAR1 | S1080 | ochoa | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}. |
| Q8N392 | ARHGAP18 | S610 | ochoa | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}. |
| Q8N3C0 | ASCC3 | S452 | ochoa | Activating signal cointegrator 1 complex subunit 3 (EC 5.6.2.4) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200) | ATPase involved both in DNA repair and rescue of stalled ribosomes (PubMed:22055184, PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184, ECO:0000269|PubMed:28757607, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q8N4S0 | CCDC82 | S131 | ochoa | Coiled-coil domain-containing protein 82 | None |
| Q8TD26 | CHD6 | S1714 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q92569 | PIK3R3 | Y199 | ochoa|psp | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. |
| Q96CN5 | LRRC45 | S337 | ochoa | Leucine-rich repeat-containing protein 45 | Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. {ECO:0000269|PubMed:24035387}. |
| Q96JI7 | SPG11 | S1829 | ochoa | Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) | May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. {ECO:0000269|PubMed:24794856}. |
| Q99801 | NKX3-1 | S185 | psp | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
| Q9BSJ6 | PIMREG | S26 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BSW2 | CRACR2A | S263 | ochoa | EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46) (EC 3.6.5.2) | [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269|PubMed:20418871, ECO:0000269|PubMed:27016526}.; FUNCTION: [Isoform 2]: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (PubMed:31092558). During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function (PubMed:31092558). Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (PubMed:30814157). Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526). In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (PubMed:27016526). Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160). Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (PubMed:27016526). {ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:29987160, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. |
| Q9BV73 | CEP250 | S264 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9C073 | FAM117A | S145 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9NQX4 | MYO5C | S1247 | ochoa | Unconventional myosin-Vc | May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues. |
| Q9NYF5 | FAM13B | S796 | ochoa | Protein FAM13B (GAP-like protein N61) | None |
| Q9UHY8 | FEZ2 | S195 | ochoa | Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) | Involved in axonal outgrowth and fasciculation. {ECO:0000250}. |
| Q9UKX2 | MYH2 | T999 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1245 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1308 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S1482 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9ULD2 | MTUS1 | S958 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULD2 | MTUS1 | S1203 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULQ1 | TPCN1 | S795 | ochoa | Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1) | Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:19620632, PubMed:23063126, PubMed:23394946, PubMed:24776928). Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable) (PubMed:23394946). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable) (PubMed:23394946). {ECO:0000269|PubMed:19620632, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:23394946, ECO:0000269|PubMed:24776928, ECO:0000305|PubMed:32679067}.; FUNCTION: (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. {ECO:0000269|PubMed:25722412}. |
| Q9UNK0 | STX8 | S159 | ochoa | Syntaxin-8 | Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. |
| Q9Y623 | MYH4 | T997 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y623 | MYH4 | S1482 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| P12270 | TPR | S135 | Sugiyama | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| O14646 | CHD1 | S1017 | Sugiyama | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| Q8N129 | CNPY4 | S45 | Sugiyama | Protein canopy homolog 4 | Plays a role in the regulation of the cell surface expression of TLR4. {ECO:0000269|PubMed:16338228}. |
| Q9BQ52 | ELAC2 | S796 | Sugiyama | Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) | Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694). {ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:24703694}. |
| Q9Y3P9 | RABGAP1 | S931 | Sugiyama | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| O60941 | DTNB | S465 | Sugiyama | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| Q9Y4J8 | DTNA | S501 | Sugiyama | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q13057 | COASY | S507 | Sugiyama | Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)] | Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:24360804}. |
| O60610 | DIAPH1 | T545 | Sugiyama | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| O15212 | PFDN6 | T84 | Sugiyama | Prefoldin subunit 6 (Protein Ke2) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| O60763 | USO1 | S805 | Sugiyama | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| O95721 | SNAP29 | S210 | Sugiyama | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
| Q8IY84 | NIM1K | S119 | Sugiyama | Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) | None |
| Q99759 | MAP3K3 | S399 | Sugiyama | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q9Y2U5 | MAP3K2 | S393 | Sugiyama | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.000056 | 4.255 |
| R-HSA-68886 | M Phase | 0.000052 | 4.283 |
| R-HSA-68875 | Mitotic Prophase | 0.000072 | 4.140 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000205 | 3.689 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000194 | 3.712 |
| R-HSA-390522 | Striated Muscle Contraction | 0.000249 | 3.605 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.000244 | 3.612 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.000722 | 3.141 |
| R-HSA-75153 | Apoptotic execution phase | 0.000762 | 3.118 |
| R-HSA-8939211 | ESR-mediated signaling | 0.000727 | 3.139 |
| R-HSA-1640170 | Cell Cycle | 0.001109 | 2.955 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.001068 | 2.971 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.001304 | 2.885 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.001503 | 2.823 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.001512 | 2.820 |
| R-HSA-5357801 | Programmed Cell Death | 0.001566 | 2.805 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.001853 | 2.732 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.002135 | 2.671 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.002385 | 2.622 |
| R-HSA-109581 | Apoptosis | 0.002410 | 2.618 |
| R-HSA-9927354 | Co-stimulation by ICOS | 0.003158 | 2.501 |
| R-HSA-449147 | Signaling by Interleukins | 0.003307 | 2.481 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.004237 | 2.373 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.004432 | 2.353 |
| R-HSA-69541 | Stabilization of p53 | 0.005105 | 2.292 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.005105 | 2.292 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.005416 | 2.266 |
| R-HSA-9907900 | Proteasome assembly | 0.007140 | 2.146 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.008701 | 2.060 |
| R-HSA-9766229 | Degradation of CDH1 | 0.009156 | 2.038 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.009156 | 2.038 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.009156 | 2.038 |
| R-HSA-68882 | Mitotic Anaphase | 0.008772 | 2.057 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.008944 | 2.048 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.009590 | 2.018 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.008190 | 2.087 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.012443 | 1.905 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.012443 | 1.905 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.013010 | 1.886 |
| R-HSA-162582 | Signal Transduction | 0.014057 | 1.852 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.014117 | 1.850 |
| R-HSA-373753 | Nephrin family interactions | 0.015244 | 1.817 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.015244 | 1.817 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.017661 | 1.753 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.016422 | 1.785 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.017512 | 1.757 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.016410 | 1.785 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.018848 | 1.725 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.018848 | 1.725 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.019147 | 1.718 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.020122 | 1.696 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.021430 | 1.669 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.021430 | 1.669 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.036490 | 1.438 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.043347 | 1.363 |
| R-HSA-6798695 | Neutrophil degranulation | 0.067222 | 1.172 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.041373 | 1.383 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.046676 | 1.331 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.031522 | 1.501 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.061928 | 1.208 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.029281 | 1.533 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.035567 | 1.449 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.071833 | 1.144 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.071833 | 1.144 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.031522 | 1.501 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.033091 | 1.480 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.039660 | 1.402 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.039660 | 1.402 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.052214 | 1.282 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.052214 | 1.282 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.063940 | 1.194 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.074319 | 1.129 |
| R-HSA-4641258 | Degradation of DVL | 0.043114 | 1.365 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.044821 | 1.349 |
| R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 0.029372 | 1.532 |
| R-HSA-199920 | CREB phosphorylation | 0.064886 | 1.188 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.064886 | 1.188 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.025560 | 1.592 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.041373 | 1.383 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.041373 | 1.383 |
| R-HSA-4641257 | Degradation of AXIN | 0.043114 | 1.365 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.043114 | 1.365 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.022396 | 1.650 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.074319 | 1.129 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.025560 | 1.592 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.036317 | 1.440 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.037974 | 1.421 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.037974 | 1.421 |
| R-HSA-169911 | Regulation of Apoptosis | 0.039660 | 1.402 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.052214 | 1.282 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.052214 | 1.282 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.070105 | 1.154 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.074319 | 1.129 |
| R-HSA-199991 | Membrane Trafficking | 0.063020 | 1.201 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.037433 | 1.427 |
| R-HSA-69275 | G2/M Transition | 0.067943 | 1.168 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.048497 | 1.314 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.050343 | 1.298 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.050343 | 1.298 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.061234 | 1.213 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.069862 | 1.156 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.033738 | 1.472 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.061234 | 1.213 |
| R-HSA-397014 | Muscle contraction | 0.030401 | 1.517 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.025560 | 1.592 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.046676 | 1.331 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.056029 | 1.252 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.057972 | 1.237 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.059939 | 1.222 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.054109 | 1.267 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.071833 | 1.144 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.059939 | 1.222 |
| R-HSA-202424 | Downstream TCR signaling | 0.038388 | 1.416 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.050343 | 1.298 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.059939 | 1.222 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.043317 | 1.363 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.032845 | 1.484 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.065974 | 1.181 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.065974 | 1.181 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.072202 | 1.141 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.056158 | 1.251 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.057022 | 1.244 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.029985 | 1.523 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.059939 | 1.222 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.059939 | 1.222 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.025560 | 1.592 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.072202 | 1.141 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.041373 | 1.383 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.022773 | 1.643 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.022773 | 1.643 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.056029 | 1.252 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.056317 | 1.249 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.072202 | 1.141 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.047535 | 1.323 |
| R-HSA-202403 | TCR signaling | 0.063679 | 1.196 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.037974 | 1.421 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.056158 | 1.251 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.056158 | 1.251 |
| R-HSA-9675108 | Nervous system development | 0.036910 | 1.433 |
| R-HSA-9824272 | Somitogenesis | 0.059939 | 1.222 |
| R-HSA-422475 | Axon guidance | 0.061728 | 1.210 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.057972 | 1.237 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.074319 | 1.129 |
| R-HSA-8853659 | RET signaling | 0.041373 | 1.383 |
| R-HSA-1500931 | Cell-Cell communication | 0.040522 | 1.392 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.051914 | 1.285 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.073783 | 1.132 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.048497 | 1.314 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 0.078728 | 1.104 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.078728 | 1.104 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 0.105806 | 0.975 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.144949 | 0.839 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.163879 | 0.785 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.163879 | 0.785 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.170096 | 0.769 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.170096 | 0.769 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.170096 | 0.769 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.170096 | 0.769 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.170096 | 0.769 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.188474 | 0.725 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.194509 | 0.711 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.206447 | 0.685 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.206447 | 0.685 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.098826 | 1.005 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.098826 | 1.005 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.105859 | 0.975 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.122761 | 0.911 |
| R-HSA-380287 | Centrosome maturation | 0.127706 | 0.894 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.184662 | 0.734 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.222533 | 0.653 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.168741 | 0.773 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.151306 | 0.820 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.188474 | 0.725 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.170096 | 0.769 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.112451 | 0.949 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.119047 | 0.924 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.132094 | 0.879 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.218210 | 0.661 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.157616 | 0.802 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.112451 | 0.949 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.157616 | 0.802 |
| R-HSA-198203 | PI3K/AKT activation | 0.092367 | 1.034 |
| R-HSA-73942 | DNA Damage Reversal | 0.132094 | 0.879 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.076456 | 1.117 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.150498 | 0.822 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.115437 | 0.938 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.085573 | 1.068 |
| R-HSA-5617833 | Cilium Assembly | 0.204967 | 0.688 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.132094 | 0.879 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.132094 | 0.879 |
| R-HSA-196783 | Coenzyme A biosynthesis | 0.144949 | 0.839 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.218210 | 0.661 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.096513 | 1.015 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.084063 | 1.075 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.151306 | 0.820 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.078612 | 1.105 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.125595 | 0.901 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.122761 | 0.911 |
| R-HSA-180292 | GAB1 signalosome | 0.157616 | 0.802 |
| R-HSA-5689603 | UCH proteinases | 0.130196 | 0.885 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.154513 | 0.811 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.166318 | 0.779 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.119047 | 0.924 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 0.151306 | 0.820 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.182393 | 0.739 |
| R-HSA-1221632 | Meiotic synapsis | 0.076456 | 1.117 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.076456 | 1.117 |
| R-HSA-77387 | Insulin receptor recycling | 0.224026 | 0.650 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.080787 | 1.093 |
| R-HSA-9659379 | Sensory processing of sound | 0.137732 | 0.861 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.179329 | 0.746 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.187337 | 0.727 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.091934 | 1.037 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.117866 | 0.929 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.117866 | 0.929 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.134437 | 0.871 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.176267 | 0.754 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.218210 | 0.661 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.110620 | 0.956 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.083403 | 1.079 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.157616 | 0.802 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.082981 | 1.081 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.084801 | 1.072 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.157616 | 0.802 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.082981 | 1.081 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.200789 | 0.697 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.127706 | 0.894 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.085573 | 1.068 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.099111 | 1.004 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.112451 | 0.949 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.151306 | 0.820 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.151306 | 0.820 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.182393 | 0.739 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.120307 | 0.920 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.094215 | 1.026 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.078728 | 1.104 |
| R-HSA-9842663 | Signaling by LTK | 0.112451 | 0.949 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.096513 | 1.015 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.094870 | 1.023 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.212351 | 0.673 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.182393 | 0.739 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 0.188474 | 0.725 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.176672 | 0.753 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.176267 | 0.754 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.176267 | 0.754 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.157616 | 0.802 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.200500 | 0.698 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.224026 | 0.650 |
| R-HSA-69481 | G2/M Checkpoints | 0.090496 | 1.043 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.114783 | 0.940 |
| R-HSA-68877 | Mitotic Prometaphase | 0.210720 | 0.676 |
| R-HSA-5688426 | Deubiquitination | 0.150357 | 0.823 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.076456 | 1.117 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.158267 | 0.801 |
| R-HSA-69239 | Synthesis of DNA | 0.222533 | 0.653 |
| R-HSA-210993 | Tie2 Signaling | 0.157616 | 0.802 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.096513 | 1.015 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.171324 | 0.766 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.091944 | 1.036 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.147925 | 0.830 |
| R-HSA-166520 | Signaling by NTRKs | 0.127759 | 0.894 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.115437 | 0.938 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.135209 | 0.869 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.150498 | 0.822 |
| R-HSA-1500620 | Meiosis | 0.153079 | 0.815 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.077910 | 1.108 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.096513 | 1.015 |
| R-HSA-351202 | Metabolism of polyamines | 0.091934 | 1.037 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.194509 | 0.711 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.080787 | 1.093 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.117866 | 0.929 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.163489 | 0.787 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.194509 | 0.711 |
| R-HSA-6807070 | PTEN Regulation | 0.111622 | 0.952 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.218210 | 0.661 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.120307 | 0.920 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.203494 | 0.691 |
| R-HSA-168256 | Immune System | 0.088229 | 1.054 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.103500 | 0.985 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.115437 | 0.938 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.125228 | 0.902 |
| R-HSA-211000 | Gene Silencing by RNA | 0.222533 | 0.653 |
| R-HSA-2262752 | Cellular responses to stress | 0.087166 | 1.060 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.190017 | 0.721 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.131083 | 0.882 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.115437 | 0.938 |
| R-HSA-5619084 | ABC transporter disorders | 0.135209 | 0.869 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.179329 | 0.746 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.132756 | 0.877 |
| R-HSA-4086400 | PCP/CE pathway | 0.135209 | 0.869 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.077814 | 1.109 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.199809 | 0.699 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.159975 | 0.796 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.120307 | 0.920 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.200789 | 0.697 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.210558 | 0.677 |
| R-HSA-418990 | Adherens junctions interactions | 0.103054 | 0.987 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.080636 | 1.093 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.094215 | 1.026 |
| R-HSA-421270 | Cell-cell junction organization | 0.144885 | 0.839 |
| R-HSA-2028269 | Signaling by Hippo | 0.151306 | 0.820 |
| R-HSA-446728 | Cell junction organization | 0.183279 | 0.737 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.103500 | 0.985 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.153079 | 0.815 |
| R-HSA-373755 | Semaphorin interactions | 0.098826 | 1.005 |
| R-HSA-1483255 | PI Metabolism | 0.206203 | 0.686 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.134437 | 0.871 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.158267 | 0.801 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.174022 | 0.759 |
| R-HSA-157118 | Signaling by NOTCH | 0.130263 | 0.885 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.130196 | 0.885 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.176672 | 0.753 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.160874 | 0.794 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.224278 | 0.649 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.224278 | 0.649 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.228000 | 0.642 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.229800 | 0.639 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.229800 | 0.639 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.229800 | 0.639 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.229800 | 0.639 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.229800 | 0.639 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.229800 | 0.639 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.230143 | 0.638 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.230143 | 0.638 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.235531 | 0.628 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.235531 | 0.628 |
| R-HSA-2424491 | DAP12 signaling | 0.235531 | 0.628 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.235531 | 0.628 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.235835 | 0.627 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.241219 | 0.618 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.241219 | 0.618 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.241219 | 0.618 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.241219 | 0.618 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.241219 | 0.618 |
| R-HSA-186763 | Downstream signal transduction | 0.241219 | 0.618 |
| R-HSA-72766 | Translation | 0.245484 | 0.610 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.246866 | 0.608 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.251877 | 0.599 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.252471 | 0.598 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.252471 | 0.598 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.252471 | 0.598 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.252471 | 0.598 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.252471 | 0.598 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.252471 | 0.598 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.252471 | 0.598 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.252471 | 0.598 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.252471 | 0.598 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.258034 | 0.588 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.258034 | 0.588 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.258034 | 0.588 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.258034 | 0.588 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.258034 | 0.588 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.258034 | 0.588 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.258034 | 0.588 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.263556 | 0.579 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.263556 | 0.579 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.263556 | 0.579 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.263556 | 0.579 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.263556 | 0.579 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.269038 | 0.570 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.269038 | 0.570 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.269038 | 0.570 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.269038 | 0.570 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.269038 | 0.570 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.269038 | 0.570 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.271970 | 0.565 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.274479 | 0.561 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.274723 | 0.561 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.279880 | 0.553 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.279880 | 0.553 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.279880 | 0.553 |
| R-HSA-162906 | HIV Infection | 0.279949 | 0.553 |
| R-HSA-69206 | G1/S Transition | 0.280227 | 0.552 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.281967 | 0.550 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 0.285242 | 0.545 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.285242 | 0.545 |
| R-HSA-73927 | Depurination | 0.285242 | 0.545 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.285242 | 0.545 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.285242 | 0.545 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.290563 | 0.537 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.290563 | 0.537 |
| R-HSA-201556 | Signaling by ALK | 0.290563 | 0.537 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.292924 | 0.533 |
| R-HSA-1266738 | Developmental Biology | 0.295635 | 0.529 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.295845 | 0.529 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.295845 | 0.529 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.295845 | 0.529 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.295845 | 0.529 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.295845 | 0.529 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.295845 | 0.529 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.295845 | 0.529 |
| R-HSA-9646399 | Aggrephagy | 0.295845 | 0.529 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.296258 | 0.528 |
| R-HSA-1474165 | Reproduction | 0.296718 | 0.528 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.301089 | 0.521 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.301089 | 0.521 |
| R-HSA-9607240 | FLT3 Signaling | 0.301089 | 0.521 |
| R-HSA-9694548 | Maturation of spike protein | 0.301089 | 0.521 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.301089 | 0.521 |
| R-HSA-9909396 | Circadian clock | 0.302204 | 0.520 |
| R-HSA-168249 | Innate Immune System | 0.305210 | 0.515 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.306293 | 0.514 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.306293 | 0.514 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.306293 | 0.514 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.311459 | 0.507 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.315888 | 0.500 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.316587 | 0.500 |
| R-HSA-8854214 | TBC/RABGAPs | 0.316587 | 0.500 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.320504 | 0.494 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.321345 | 0.493 |
| R-HSA-5683826 | Surfactant metabolism | 0.321678 | 0.493 |
| R-HSA-2172127 | DAP12 interactions | 0.321678 | 0.493 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.324070 | 0.489 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.326730 | 0.486 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.326730 | 0.486 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.326730 | 0.486 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.326730 | 0.486 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.326793 | 0.486 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.326793 | 0.486 |
| R-HSA-9664407 | Parasite infection | 0.326793 | 0.486 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.331745 | 0.479 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.331745 | 0.479 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.331745 | 0.479 |
| R-HSA-9675135 | Diseases of DNA repair | 0.331745 | 0.479 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.334841 | 0.475 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.334943 | 0.475 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.336723 | 0.473 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.340360 | 0.468 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.345765 | 0.461 |
| R-HSA-69242 | S Phase | 0.351155 | 0.455 |
| R-HSA-109704 | PI3K Cascade | 0.351438 | 0.454 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.351438 | 0.454 |
| R-HSA-392499 | Metabolism of proteins | 0.351749 | 0.454 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.353033 | 0.452 |
| R-HSA-9758941 | Gastrulation | 0.353845 | 0.451 |
| R-HSA-913531 | Interferon Signaling | 0.355166 | 0.450 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.356531 | 0.448 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.363173 | 0.440 |
| R-HSA-69306 | DNA Replication | 0.364564 | 0.438 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.365829 | 0.437 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.365829 | 0.437 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.369899 | 0.432 |
| R-HSA-72649 | Translation initiation complex formation | 0.370555 | 0.431 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.370555 | 0.431 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.370555 | 0.431 |
| R-HSA-597592 | Post-translational protein modification | 0.371199 | 0.430 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.375247 | 0.426 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.379903 | 0.420 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.379903 | 0.420 |
| R-HSA-177929 | Signaling by EGFR | 0.379903 | 0.420 |
| R-HSA-877300 | Interferon gamma signaling | 0.380517 | 0.420 |
| R-HSA-112399 | IRS-mediated signalling | 0.384526 | 0.415 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.389114 | 0.410 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.393668 | 0.405 |
| R-HSA-191859 | snRNP Assembly | 0.393668 | 0.405 |
| R-HSA-180786 | Extension of Telomeres | 0.393668 | 0.405 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.393684 | 0.405 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.398188 | 0.400 |
| R-HSA-983189 | Kinesins | 0.398188 | 0.400 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.398188 | 0.400 |
| R-HSA-1280218 | Adaptive Immune System | 0.400365 | 0.398 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.402675 | 0.395 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.402675 | 0.395 |
| R-HSA-450294 | MAP kinase activation | 0.402675 | 0.395 |
| R-HSA-1442490 | Collagen degradation | 0.402675 | 0.395 |
| R-HSA-1268020 | Mitochondrial protein import | 0.407129 | 0.390 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.407129 | 0.390 |
| R-HSA-186797 | Signaling by PDGF | 0.407129 | 0.390 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.407129 | 0.390 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.411550 | 0.386 |
| R-HSA-72306 | tRNA processing | 0.411905 | 0.385 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.414486 | 0.382 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.415939 | 0.381 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.415939 | 0.381 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.420294 | 0.376 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.428910 | 0.368 |
| R-HSA-9679506 | SARS-CoV Infections | 0.429105 | 0.367 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.433169 | 0.363 |
| R-HSA-5218859 | Regulated Necrosis | 0.433169 | 0.363 |
| R-HSA-168255 | Influenza Infection | 0.434934 | 0.362 |
| R-HSA-2559583 | Cellular Senescence | 0.437463 | 0.359 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.441595 | 0.355 |
| R-HSA-448424 | Interleukin-17 signaling | 0.441595 | 0.355 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.445015 | 0.352 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.445761 | 0.351 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.445761 | 0.351 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.449896 | 0.347 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.449896 | 0.347 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.454001 | 0.343 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.454001 | 0.343 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.458075 | 0.339 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.458075 | 0.339 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.458075 | 0.339 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.462119 | 0.335 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.466133 | 0.331 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.466249 | 0.331 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.470118 | 0.328 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.474072 | 0.324 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.474072 | 0.324 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.477998 | 0.321 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.481895 | 0.317 |
| R-HSA-6806834 | Signaling by MET | 0.481895 | 0.317 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.485762 | 0.314 |
| R-HSA-1474244 | Extracellular matrix organization | 0.487192 | 0.312 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.489602 | 0.310 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.491399 | 0.309 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.500949 | 0.300 |
| R-HSA-6805567 | Keratinization | 0.503330 | 0.298 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.508375 | 0.294 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.512047 | 0.291 |
| R-HSA-156902 | Peptide chain elongation | 0.515691 | 0.288 |
| R-HSA-9663891 | Selective autophagy | 0.515691 | 0.288 |
| R-HSA-73884 | Base Excision Repair | 0.522899 | 0.282 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.526463 | 0.279 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.526463 | 0.279 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.530001 | 0.276 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.533513 | 0.273 |
| R-HSA-391251 | Protein folding | 0.533513 | 0.273 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.533513 | 0.273 |
| R-HSA-8951664 | Neddylation | 0.537743 | 0.269 |
| R-HSA-73894 | DNA Repair | 0.540432 | 0.267 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.540458 | 0.267 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.547300 | 0.262 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.547300 | 0.262 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.548848 | 0.261 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.550684 | 0.259 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.550684 | 0.259 |
| R-HSA-157579 | Telomere Maintenance | 0.554042 | 0.256 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.557375 | 0.254 |
| R-HSA-190236 | Signaling by FGFR | 0.557375 | 0.254 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.557375 | 0.254 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.557375 | 0.254 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.557375 | 0.254 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.557599 | 0.254 |
| R-HSA-3214847 | HATs acetylate histones | 0.560684 | 0.251 |
| R-HSA-72312 | rRNA processing | 0.561929 | 0.250 |
| R-HSA-1643685 | Disease | 0.562909 | 0.250 |
| R-HSA-70171 | Glycolysis | 0.563968 | 0.249 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.566230 | 0.247 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.567228 | 0.246 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.570463 | 0.244 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.570463 | 0.244 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.570463 | 0.244 |
| R-HSA-192823 | Viral mRNA Translation | 0.573675 | 0.241 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.576862 | 0.239 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.576862 | 0.239 |
| R-HSA-9833110 | RSV-host interactions | 0.580027 | 0.237 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.582053 | 0.235 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.583167 | 0.234 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.586285 | 0.232 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.592450 | 0.227 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.592450 | 0.227 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.592450 | 0.227 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.592450 | 0.227 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.595499 | 0.225 |
| R-HSA-4839726 | Chromatin organization | 0.597522 | 0.224 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.598525 | 0.223 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.598525 | 0.223 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.604509 | 0.219 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.604509 | 0.219 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.604509 | 0.219 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.607468 | 0.216 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.610405 | 0.214 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.613321 | 0.212 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.616214 | 0.210 |
| R-HSA-8953854 | Metabolism of RNA | 0.618762 | 0.208 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.619086 | 0.208 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.619086 | 0.208 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.619086 | 0.208 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.621937 | 0.206 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.621937 | 0.206 |
| R-HSA-373760 | L1CAM interactions | 0.621937 | 0.206 |
| R-HSA-70326 | Glucose metabolism | 0.624767 | 0.204 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.624767 | 0.204 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.624767 | 0.204 |
| R-HSA-416476 | G alpha (q) signalling events | 0.627110 | 0.203 |
| R-HSA-5693538 | Homology Directed Repair | 0.627576 | 0.202 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.630364 | 0.200 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.630364 | 0.200 |
| R-HSA-73886 | Chromosome Maintenance | 0.635877 | 0.197 |
| R-HSA-3371556 | Cellular response to heat stress | 0.635877 | 0.197 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.638604 | 0.195 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.638604 | 0.195 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.645892 | 0.190 |
| R-HSA-194138 | Signaling by VEGF | 0.649307 | 0.188 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.655002 | 0.184 |
| R-HSA-9658195 | Leishmania infection | 0.658594 | 0.181 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.658594 | 0.181 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.660379 | 0.180 |
| R-HSA-9843745 | Adipogenesis | 0.667288 | 0.176 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.669781 | 0.174 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.669781 | 0.174 |
| R-HSA-1483257 | Phospholipid metabolism | 0.682912 | 0.166 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.684354 | 0.165 |
| R-HSA-195721 | Signaling by WNT | 0.687937 | 0.162 |
| R-HSA-1632852 | Macroautophagy | 0.693714 | 0.159 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.698290 | 0.156 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.700552 | 0.155 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.705428 | 0.152 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.711614 | 0.148 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.722271 | 0.141 |
| R-HSA-9609507 | Protein localization | 0.722271 | 0.141 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.724355 | 0.140 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.724355 | 0.140 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.727329 | 0.138 |
| R-HSA-9612973 | Autophagy | 0.728477 | 0.138 |
| R-HSA-8957322 | Metabolism of steroids | 0.728814 | 0.137 |
| R-HSA-9610379 | HCMV Late Events | 0.730515 | 0.136 |
| R-HSA-162587 | HIV Life Cycle | 0.730515 | 0.136 |
| R-HSA-9711097 | Cellular response to starvation | 0.732538 | 0.135 |
| R-HSA-74160 | Gene expression (Transcription) | 0.734113 | 0.134 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.744362 | 0.128 |
| R-HSA-212436 | Generic Transcription Pathway | 0.745581 | 0.128 |
| R-HSA-5619102 | SLC transporter disorders | 0.750078 | 0.125 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.757502 | 0.121 |
| R-HSA-9824446 | Viral Infection Pathways | 0.759526 | 0.119 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.762927 | 0.118 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.762927 | 0.118 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.766476 | 0.116 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.766476 | 0.116 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.782864 | 0.106 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.788297 | 0.103 |
| R-HSA-983712 | Ion channel transport | 0.789889 | 0.102 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.793038 | 0.101 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.797674 | 0.098 |
| R-HSA-9609690 | HCMV Early Events | 0.800707 | 0.097 |
| R-HSA-72172 | mRNA Splicing | 0.813807 | 0.089 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.824733 | 0.084 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.834043 | 0.079 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.854942 | 0.068 |
| R-HSA-9609646 | HCMV Infection | 0.868547 | 0.061 |
| R-HSA-112316 | Neuronal System | 0.882422 | 0.054 |
| R-HSA-5663205 | Infectious disease | 0.901663 | 0.045 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.924503 | 0.034 |
| R-HSA-109582 | Hemostasis | 0.942446 | 0.026 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.972694 | 0.012 |
| R-HSA-382551 | Transport of small molecules | 0.981877 | 0.008 |
| R-HSA-388396 | GPCR downstream signalling | 0.983379 | 0.007 |
| R-HSA-372790 | Signaling by GPCR | 0.990520 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 0.997019 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999356 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999985 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.764 | 0.509 | 2 | 0.865 |
RSK2 |
0.745 | 0.160 | -3 | 0.857 |
PIM1 |
0.744 | 0.154 | -3 | 0.854 |
PRKD2 |
0.744 | 0.148 | -3 | 0.844 |
ATM |
0.743 | 0.260 | 1 | 0.867 |
PIM3 |
0.742 | 0.108 | -3 | 0.868 |
SKMLCK |
0.741 | 0.186 | -2 | 0.799 |
CAMK1B |
0.741 | 0.132 | -3 | 0.870 |
CLK3 |
0.740 | 0.108 | 1 | 0.754 |
P70S6KB |
0.740 | 0.136 | -3 | 0.858 |
RSK3 |
0.739 | 0.143 | -3 | 0.861 |
P90RSK |
0.739 | 0.143 | -3 | 0.852 |
PRKD3 |
0.739 | 0.154 | -3 | 0.842 |
CAMLCK |
0.739 | 0.167 | -2 | 0.792 |
COT |
0.738 | 0.039 | 2 | 0.469 |
MYLK4 |
0.737 | 0.179 | -2 | 0.768 |
CDKL1 |
0.737 | 0.128 | -3 | 0.855 |
DAPK2 |
0.737 | 0.184 | -3 | 0.853 |
ATR |
0.736 | 0.195 | 1 | 0.859 |
PRKD1 |
0.735 | 0.100 | -3 | 0.839 |
SMG1 |
0.735 | 0.346 | 1 | 0.843 |
CDC7 |
0.734 | 0.039 | 1 | 0.827 |
PKN3 |
0.734 | 0.081 | -3 | 0.845 |
PIM2 |
0.734 | 0.154 | -3 | 0.838 |
RSK4 |
0.733 | 0.145 | -3 | 0.835 |
PKCD |
0.733 | 0.061 | 2 | 0.407 |
MAPKAPK3 |
0.733 | 0.131 | -3 | 0.835 |
RIPK3 |
0.733 | 0.103 | 3 | 0.714 |
CDKL5 |
0.733 | 0.097 | -3 | 0.848 |
NDR1 |
0.733 | 0.072 | -3 | 0.856 |
NDR2 |
0.732 | 0.049 | -3 | 0.847 |
CAMK2B |
0.731 | 0.179 | 2 | 0.551 |
WNK1 |
0.731 | 0.056 | -2 | 0.775 |
NLK |
0.731 | 0.073 | 1 | 0.684 |
AURB |
0.730 | 0.099 | -2 | 0.695 |
MAPKAPK2 |
0.730 | 0.142 | -3 | 0.830 |
PKACG |
0.730 | 0.102 | -2 | 0.777 |
SMMLCK |
0.730 | 0.178 | -3 | 0.850 |
SRPK1 |
0.729 | 0.109 | -3 | 0.843 |
TGFBR2 |
0.729 | 0.043 | -2 | 0.705 |
MOS |
0.729 | 0.005 | 1 | 0.805 |
PRPK |
0.728 | -0.027 | -1 | 0.422 |
MSK1 |
0.728 | 0.149 | -3 | 0.831 |
NIK |
0.728 | 0.050 | -3 | 0.847 |
AURC |
0.728 | 0.077 | -2 | 0.700 |
PKG2 |
0.728 | 0.121 | -2 | 0.737 |
NUAK2 |
0.728 | 0.056 | -3 | 0.864 |
PKN2 |
0.728 | 0.051 | -3 | 0.838 |
CAMK2D |
0.727 | 0.127 | -3 | 0.830 |
MELK |
0.727 | 0.087 | -3 | 0.842 |
PKACB |
0.727 | 0.123 | -2 | 0.729 |
DAPK3 |
0.727 | 0.191 | -3 | 0.858 |
LATS2 |
0.726 | 0.047 | -5 | 0.644 |
PKCB |
0.726 | 0.043 | 2 | 0.377 |
CLK1 |
0.726 | 0.116 | -3 | 0.842 |
AKT2 |
0.726 | 0.138 | -3 | 0.813 |
MST4 |
0.726 | 0.009 | 2 | 0.473 |
LATS1 |
0.726 | 0.120 | -3 | 0.854 |
MSK2 |
0.726 | 0.118 | -3 | 0.826 |
PAK3 |
0.726 | 0.064 | -2 | 0.749 |
ICK |
0.725 | 0.069 | -3 | 0.859 |
PAK1 |
0.725 | 0.060 | -2 | 0.751 |
BMPR2 |
0.725 | 0.020 | -2 | 0.769 |
CAMK4 |
0.725 | 0.073 | -3 | 0.838 |
CLK4 |
0.725 | 0.116 | -3 | 0.849 |
DSTYK |
0.725 | 0.040 | 2 | 0.524 |
NUAK1 |
0.724 | 0.057 | -3 | 0.857 |
MNK2 |
0.724 | 0.053 | -2 | 0.768 |
WNK3 |
0.724 | 0.019 | 1 | 0.685 |
PRKX |
0.724 | 0.140 | -3 | 0.788 |
BMPR1B |
0.724 | 0.106 | 1 | 0.789 |
CAMK1G |
0.723 | 0.102 | -3 | 0.841 |
CAMK2G |
0.723 | 0.029 | 2 | 0.486 |
SRPK2 |
0.723 | 0.112 | -3 | 0.805 |
TSSK1 |
0.723 | 0.035 | -3 | 0.862 |
CAMK1D |
0.723 | 0.151 | -3 | 0.810 |
RAF1 |
0.723 | -0.048 | 1 | 0.706 |
P70S6K |
0.723 | 0.131 | -3 | 0.810 |
SGK3 |
0.722 | 0.103 | -3 | 0.825 |
IRE2 |
0.722 | 0.000 | 2 | 0.369 |
TSSK2 |
0.722 | 0.041 | -5 | 0.664 |
ERK5 |
0.721 | 0.018 | 1 | 0.657 |
PKR |
0.721 | 0.049 | 1 | 0.767 |
CAMK2A |
0.721 | 0.100 | 2 | 0.484 |
PKCH |
0.721 | 0.035 | 2 | 0.358 |
HIPK4 |
0.720 | 0.041 | 1 | 0.711 |
PKACA |
0.720 | 0.132 | -2 | 0.704 |
AMPKA1 |
0.720 | 0.012 | -3 | 0.852 |
PDHK4 |
0.720 | -0.035 | 1 | 0.712 |
CLK2 |
0.719 | 0.120 | -3 | 0.858 |
MLK1 |
0.719 | -0.037 | 2 | 0.432 |
RIPK1 |
0.719 | 0.025 | 1 | 0.733 |
AKT1 |
0.719 | 0.128 | -3 | 0.814 |
GCN2 |
0.719 | -0.082 | 2 | 0.400 |
MNK1 |
0.718 | 0.048 | -2 | 0.781 |
DNAPK |
0.718 | 0.193 | 1 | 0.737 |
MAPKAPK5 |
0.718 | 0.122 | -3 | 0.799 |
PHKG1 |
0.718 | 0.028 | -3 | 0.846 |
SIK |
0.718 | 0.070 | -3 | 0.832 |
PKCG |
0.718 | 0.011 | 2 | 0.365 |
PAK2 |
0.718 | 0.056 | -2 | 0.729 |
PKCA |
0.717 | 0.014 | 2 | 0.380 |
ALK2 |
0.717 | 0.127 | -2 | 0.729 |
PAK6 |
0.717 | 0.059 | -2 | 0.672 |
DAPK1 |
0.717 | 0.160 | -3 | 0.843 |
AMPKA2 |
0.716 | 0.033 | -3 | 0.849 |
TGFBR1 |
0.716 | 0.074 | -2 | 0.725 |
AURA |
0.716 | 0.085 | -2 | 0.664 |
NIM1 |
0.716 | -0.008 | 3 | 0.656 |
CAMK1A |
0.716 | 0.139 | -3 | 0.798 |
BMPR1A |
0.716 | 0.108 | 1 | 0.774 |
ULK2 |
0.715 | -0.134 | 2 | 0.390 |
SRPK3 |
0.715 | 0.087 | -3 | 0.824 |
IRE1 |
0.715 | -0.051 | 1 | 0.738 |
CHAK2 |
0.715 | -0.072 | -1 | 0.423 |
MARK4 |
0.714 | -0.009 | 4 | 0.741 |
ALK4 |
0.714 | 0.036 | -2 | 0.738 |
ANKRD3 |
0.714 | -0.050 | 1 | 0.729 |
DCAMKL1 |
0.714 | 0.062 | -3 | 0.853 |
PKCZ |
0.714 | -0.014 | 2 | 0.397 |
NEK9 |
0.713 | -0.069 | 2 | 0.429 |
MLK3 |
0.713 | -0.024 | 2 | 0.391 |
MRCKB |
0.713 | 0.145 | -3 | 0.825 |
PKCT |
0.713 | 0.037 | 2 | 0.368 |
CHK2 |
0.713 | 0.139 | -3 | 0.781 |
ACVR2B |
0.712 | 0.064 | -2 | 0.703 |
GRK6 |
0.712 | -0.002 | 1 | 0.772 |
CHK1 |
0.712 | 0.031 | -3 | 0.843 |
NEK7 |
0.712 | -0.103 | -3 | 0.714 |
TBK1 |
0.712 | -0.078 | 1 | 0.545 |
ACVR2A |
0.711 | 0.047 | -2 | 0.687 |
MLK2 |
0.711 | -0.078 | 2 | 0.427 |
SNRK |
0.711 | 0.005 | 2 | 0.306 |
QIK |
0.711 | 0.000 | -3 | 0.817 |
AKT3 |
0.711 | 0.130 | -3 | 0.772 |
DCAMKL2 |
0.711 | 0.048 | -3 | 0.863 |
SGK1 |
0.711 | 0.143 | -3 | 0.762 |
HUNK |
0.711 | -0.109 | 2 | 0.357 |
MRCKA |
0.710 | 0.136 | -3 | 0.833 |
ROCK2 |
0.710 | 0.135 | -3 | 0.835 |
DRAK1 |
0.709 | 0.025 | 1 | 0.741 |
IKKB |
0.709 | -0.051 | -2 | 0.644 |
PDHK1 |
0.709 | -0.162 | 1 | 0.673 |
HIPK1 |
0.709 | 0.047 | 1 | 0.607 |
MLK4 |
0.709 | -0.045 | 2 | 0.386 |
IRAK4 |
0.709 | -0.013 | 1 | 0.720 |
CHAK1 |
0.709 | -0.059 | 2 | 0.370 |
PKCE |
0.708 | 0.060 | 2 | 0.359 |
PHKG2 |
0.708 | 0.034 | -3 | 0.841 |
DYRK1A |
0.708 | 0.062 | 1 | 0.607 |
NEK6 |
0.708 | -0.124 | -2 | 0.729 |
QSK |
0.708 | 0.012 | 4 | 0.716 |
BRSK1 |
0.707 | 0.039 | -3 | 0.853 |
GRK5 |
0.707 | -0.108 | -3 | 0.755 |
PKG1 |
0.707 | 0.126 | -2 | 0.682 |
PKCI |
0.707 | 0.018 | 2 | 0.381 |
DYRK2 |
0.707 | 0.026 | 1 | 0.606 |
DLK |
0.706 | -0.107 | 1 | 0.712 |
DMPK1 |
0.706 | 0.143 | -3 | 0.847 |
PKN1 |
0.706 | 0.081 | -3 | 0.815 |
MTOR |
0.705 | -0.164 | 1 | 0.626 |
CDK7 |
0.705 | -0.019 | 1 | 0.545 |
GRK1 |
0.705 | 0.012 | -2 | 0.714 |
NEK2 |
0.705 | -0.080 | 2 | 0.411 |
TTBK2 |
0.705 | -0.093 | 2 | 0.329 |
HIPK3 |
0.705 | 0.039 | 1 | 0.570 |
WNK4 |
0.705 | -0.023 | -2 | 0.734 |
SSTK |
0.705 | 0.016 | 4 | 0.730 |
MASTL |
0.704 | -0.129 | -2 | 0.697 |
ULK1 |
0.704 | -0.148 | -3 | 0.695 |
DYRK3 |
0.704 | 0.079 | 1 | 0.620 |
PLK1 |
0.704 | -0.064 | -2 | 0.697 |
ROCK1 |
0.703 | 0.135 | -3 | 0.828 |
IKKE |
0.703 | -0.097 | 1 | 0.536 |
MEK1 |
0.703 | -0.061 | 2 | 0.413 |
PERK |
0.702 | -0.061 | -2 | 0.710 |
CRIK |
0.701 | 0.151 | -3 | 0.813 |
ERK7 |
0.701 | 0.016 | 2 | 0.342 |
MARK2 |
0.701 | 0.007 | 4 | 0.628 |
BCKDK |
0.701 | -0.123 | -1 | 0.383 |
BUB1 |
0.700 | 0.072 | -5 | 0.652 |
PAK5 |
0.700 | 0.046 | -2 | 0.628 |
MARK1 |
0.700 | 0.010 | 4 | 0.690 |
HRI |
0.700 | -0.082 | -2 | 0.728 |
PAK4 |
0.700 | 0.050 | -2 | 0.640 |
HIPK2 |
0.700 | 0.023 | 1 | 0.518 |
VRK2 |
0.700 | -0.129 | 1 | 0.754 |
IRAK1 |
0.700 | -0.022 | -1 | 0.412 |
BRSK2 |
0.700 | -0.014 | -3 | 0.837 |
GRK4 |
0.699 | -0.068 | -2 | 0.731 |
PLK3 |
0.699 | -0.022 | 2 | 0.418 |
BRAF |
0.699 | -0.045 | -4 | 0.771 |
P38A |
0.699 | -0.005 | 1 | 0.559 |
CDK14 |
0.698 | 0.011 | 1 | 0.523 |
SBK |
0.698 | 0.129 | -3 | 0.749 |
NEK5 |
0.698 | -0.051 | 1 | 0.729 |
GRK2 |
0.698 | -0.014 | -2 | 0.653 |
CDK5 |
0.697 | -0.034 | 1 | 0.576 |
TLK1 |
0.697 | -0.041 | -2 | 0.743 |
MOK |
0.697 | 0.075 | 1 | 0.651 |
CDK8 |
0.696 | -0.041 | 1 | 0.522 |
CDK18 |
0.696 | -0.022 | 1 | 0.490 |
MARK3 |
0.696 | -0.016 | 4 | 0.658 |
TLK2 |
0.696 | -0.071 | 1 | 0.751 |
PASK |
0.696 | 0.019 | -3 | 0.846 |
CDK2 |
0.696 | -0.014 | 1 | 0.612 |
ERK2 |
0.695 | -0.022 | 1 | 0.537 |
IKKA |
0.695 | -0.067 | -2 | 0.627 |
DYRK1B |
0.695 | 0.024 | 1 | 0.555 |
MST3 |
0.695 | -0.043 | 2 | 0.420 |
MEK5 |
0.694 | -0.124 | 2 | 0.411 |
PINK1 |
0.694 | -0.079 | 1 | 0.720 |
YSK4 |
0.693 | -0.124 | 1 | 0.611 |
JNK2 |
0.693 | -0.009 | 1 | 0.484 |
MEKK2 |
0.693 | -0.093 | 2 | 0.402 |
DYRK4 |
0.692 | 0.031 | 1 | 0.521 |
KIS |
0.692 | -0.034 | 1 | 0.555 |
CDK17 |
0.692 | -0.028 | 1 | 0.451 |
MEKK1 |
0.692 | -0.121 | 1 | 0.664 |
GRK7 |
0.691 | -0.032 | 1 | 0.707 |
NEK8 |
0.691 | -0.063 | 2 | 0.409 |
CDK10 |
0.691 | -0.005 | 1 | 0.519 |
PLK4 |
0.691 | -0.107 | 2 | 0.247 |
LOK |
0.690 | -0.014 | -2 | 0.708 |
CDK19 |
0.690 | -0.046 | 1 | 0.486 |
TAO2 |
0.690 | -0.047 | 2 | 0.445 |
MEKK3 |
0.689 | -0.115 | 1 | 0.668 |
TTBK1 |
0.688 | -0.060 | 2 | 0.270 |
P38B |
0.688 | -0.015 | 1 | 0.499 |
MAK |
0.688 | 0.058 | -2 | 0.630 |
ERK1 |
0.688 | -0.033 | 1 | 0.478 |
JNK3 |
0.687 | -0.031 | 1 | 0.521 |
ZAK |
0.687 | -0.153 | 1 | 0.622 |
MPSK1 |
0.686 | -0.066 | 1 | 0.660 |
NEK4 |
0.686 | -0.071 | 1 | 0.660 |
CDK1 |
0.686 | -0.041 | 1 | 0.537 |
CDK16 |
0.686 | -0.021 | 1 | 0.466 |
CDK13 |
0.686 | -0.063 | 1 | 0.518 |
TTK |
0.686 | 0.044 | -2 | 0.716 |
GAK |
0.685 | -0.044 | 1 | 0.710 |
TAO3 |
0.685 | -0.093 | 1 | 0.654 |
PDK1 |
0.685 | -0.033 | 1 | 0.652 |
CDK9 |
0.685 | -0.057 | 1 | 0.519 |
CDK3 |
0.685 | -0.006 | 1 | 0.469 |
EEF2K |
0.684 | -0.065 | 3 | 0.643 |
P38G |
0.683 | -0.038 | 1 | 0.435 |
MEKK6 |
0.683 | -0.095 | 1 | 0.638 |
TNIK |
0.683 | -0.046 | 3 | 0.680 |
CAMKK1 |
0.683 | -0.097 | -2 | 0.644 |
CDK12 |
0.682 | -0.057 | 1 | 0.491 |
LRRK2 |
0.682 | -0.085 | 2 | 0.434 |
NEK1 |
0.681 | -0.068 | 1 | 0.682 |
CAMKK2 |
0.681 | -0.109 | -2 | 0.648 |
TAK1 |
0.680 | -0.015 | 1 | 0.693 |
VRK1 |
0.680 | -0.054 | 2 | 0.393 |
HASPIN |
0.680 | -0.021 | -1 | 0.329 |
HGK |
0.680 | -0.075 | 3 | 0.680 |
NEK11 |
0.680 | -0.146 | 1 | 0.640 |
GRK3 |
0.679 | -0.028 | -2 | 0.623 |
CDK4 |
0.679 | -0.020 | 1 | 0.484 |
PRP4 |
0.679 | -0.062 | -3 | 0.624 |
HPK1 |
0.678 | -0.038 | 1 | 0.641 |
SLK |
0.678 | -0.063 | -2 | 0.645 |
LKB1 |
0.678 | -0.116 | -3 | 0.710 |
CK2A2 |
0.678 | -0.004 | 1 | 0.701 |
MINK |
0.677 | -0.069 | 1 | 0.629 |
STK33 |
0.677 | -0.092 | 2 | 0.268 |
PLK2 |
0.677 | -0.007 | -3 | 0.766 |
MST2 |
0.677 | -0.100 | 1 | 0.669 |
GCK |
0.677 | -0.082 | 1 | 0.659 |
RIPK2 |
0.676 | -0.066 | 1 | 0.578 |
P38D |
0.675 | -0.026 | 1 | 0.457 |
KHS2 |
0.675 | -0.038 | 1 | 0.641 |
CDK6 |
0.675 | -0.037 | 1 | 0.490 |
YSK1 |
0.674 | -0.090 | 2 | 0.421 |
MAP3K15 |
0.674 | -0.133 | 1 | 0.595 |
CK1E |
0.673 | -0.061 | -3 | 0.445 |
MEK2 |
0.673 | -0.099 | 2 | 0.389 |
GSK3B |
0.673 | -0.036 | 4 | 0.403 |
KHS1 |
0.673 | -0.069 | 1 | 0.619 |
BIKE |
0.673 | 0.006 | 1 | 0.580 |
NEK3 |
0.672 | -0.100 | 1 | 0.588 |
PBK |
0.672 | -0.052 | 1 | 0.614 |
ALPHAK3 |
0.671 | 0.045 | -1 | 0.352 |
MYO3B |
0.669 | -0.043 | 2 | 0.428 |
MST1 |
0.668 | -0.136 | 1 | 0.645 |
CK1D |
0.667 | -0.046 | -3 | 0.388 |
CK2A1 |
0.667 | -0.008 | 1 | 0.683 |
CK1A2 |
0.666 | -0.057 | -3 | 0.399 |
TNK2 |
0.666 | 0.211 | 3 | 0.790 |
EPHA6 |
0.665 | 0.136 | -1 | 0.435 |
MYO3A |
0.665 | -0.055 | 1 | 0.673 |
GSK3A |
0.664 | -0.051 | 4 | 0.414 |
JNK1 |
0.664 | -0.038 | 1 | 0.489 |
OSR1 |
0.662 | -0.101 | 2 | 0.401 |
TEC |
0.661 | 0.209 | -1 | 0.526 |
YANK3 |
0.660 | -0.055 | 2 | 0.180 |
EPHB4 |
0.660 | 0.148 | -1 | 0.475 |
TAO1 |
0.659 | -0.082 | 1 | 0.559 |
AXL |
0.659 | 0.204 | 3 | 0.757 |
AAK1 |
0.659 | 0.008 | 1 | 0.480 |
MERTK |
0.658 | 0.219 | 3 | 0.723 |
YES1 |
0.658 | 0.147 | -1 | 0.485 |
CK1G1 |
0.658 | -0.088 | -3 | 0.461 |
TYRO3 |
0.657 | 0.153 | 3 | 0.718 |
SRMS |
0.657 | 0.216 | 1 | 0.778 |
TXK |
0.657 | 0.171 | 1 | 0.762 |
ABL2 |
0.655 | 0.109 | -1 | 0.449 |
BLK |
0.655 | 0.156 | -1 | 0.458 |
PDHK3_TYR |
0.654 | -0.002 | 4 | 0.854 |
EPHA1 |
0.654 | 0.196 | 3 | 0.757 |
LTK |
0.653 | 0.129 | 3 | 0.720 |
EPHA7 |
0.653 | 0.155 | 2 | 0.418 |
ASK1 |
0.653 | -0.131 | 1 | 0.580 |
EPHB1 |
0.652 | 0.141 | 1 | 0.760 |
LIMK2_TYR |
0.652 | 0.006 | -3 | 0.811 |
BMX |
0.651 | 0.124 | -1 | 0.473 |
LCK |
0.651 | 0.123 | -1 | 0.452 |
EPHB2 |
0.650 | 0.135 | -1 | 0.469 |
TESK1_TYR |
0.650 | -0.053 | 3 | 0.688 |
EPHB3 |
0.650 | 0.125 | -1 | 0.480 |
ROS1 |
0.649 | 0.037 | 3 | 0.716 |
EPHA5 |
0.649 | 0.164 | 2 | 0.430 |
EPHA4 |
0.649 | 0.090 | 2 | 0.427 |
HCK |
0.648 | 0.133 | -1 | 0.477 |
INSRR |
0.648 | 0.083 | 3 | 0.700 |
RET |
0.648 | 0.029 | 1 | 0.662 |
FER |
0.648 | 0.090 | 1 | 0.788 |
ALK |
0.648 | 0.082 | 3 | 0.711 |
MST1R |
0.648 | 0.051 | 3 | 0.751 |
PTK2B |
0.648 | 0.119 | -1 | 0.490 |
TEK |
0.647 | 0.116 | 3 | 0.708 |
BTK |
0.647 | 0.175 | -1 | 0.530 |
DDR1 |
0.647 | 0.060 | 4 | 0.786 |
ITK |
0.647 | 0.090 | -1 | 0.480 |
ABL1 |
0.647 | 0.058 | -1 | 0.452 |
PDGFRB |
0.646 | 0.028 | 3 | 0.756 |
CSF1R |
0.646 | 0.058 | 3 | 0.761 |
MAP2K4_TYR |
0.645 | -0.072 | -1 | 0.430 |
PINK1_TYR |
0.645 | -0.089 | 1 | 0.726 |
MAP2K6_TYR |
0.645 | -0.044 | -1 | 0.406 |
DDR2 |
0.644 | 0.112 | 3 | 0.741 |
PDHK4_TYR |
0.644 | -0.047 | 2 | 0.475 |
PKMYT1_TYR |
0.644 | -0.127 | 3 | 0.705 |
BMPR2_TYR |
0.644 | -0.036 | -1 | 0.386 |
STLK3 |
0.644 | -0.128 | 1 | 0.600 |
MAP2K7_TYR |
0.644 | -0.132 | 2 | 0.448 |
EPHA3 |
0.643 | 0.078 | 2 | 0.400 |
LIMK1_TYR |
0.643 | -0.097 | 2 | 0.449 |
TNK1 |
0.642 | -0.021 | 3 | 0.689 |
FLT3 |
0.642 | 0.031 | 3 | 0.721 |
TYK2 |
0.642 | -0.049 | 1 | 0.647 |
KDR |
0.642 | 0.018 | 3 | 0.751 |
FGFR2 |
0.642 | 0.050 | 3 | 0.722 |
FRK |
0.640 | 0.103 | -1 | 0.508 |
FYN |
0.640 | 0.088 | -1 | 0.415 |
LYN |
0.639 | 0.126 | 3 | 0.695 |
EPHA8 |
0.638 | 0.073 | -1 | 0.421 |
WEE1_TYR |
0.638 | -0.013 | -1 | 0.414 |
PDHK1_TYR |
0.638 | -0.092 | -1 | 0.410 |
KIT |
0.638 | 0.013 | 3 | 0.761 |
FGR |
0.637 | -0.032 | 1 | 0.729 |
JAK2 |
0.637 | -0.046 | 1 | 0.625 |
JAK3 |
0.636 | -0.053 | 1 | 0.646 |
MET |
0.636 | 0.009 | 3 | 0.753 |
FGFR1 |
0.636 | 0.004 | 3 | 0.737 |
PDGFRA |
0.635 | -0.019 | 3 | 0.756 |
JAK1 |
0.635 | -0.007 | 1 | 0.562 |
NTRK2 |
0.635 | 0.026 | 3 | 0.737 |
NTRK1 |
0.633 | 0.018 | -1 | 0.414 |
FGFR3 |
0.632 | 0.027 | 3 | 0.721 |
INSR |
0.631 | 0.002 | 3 | 0.684 |
PTK6 |
0.631 | -0.053 | -1 | 0.420 |
EPHA2 |
0.630 | 0.076 | -1 | 0.412 |
SRC |
0.630 | 0.047 | -1 | 0.429 |
MATK |
0.630 | -0.030 | -1 | 0.366 |
YANK2 |
0.629 | -0.070 | 2 | 0.208 |
PTK2 |
0.628 | 0.013 | -1 | 0.339 |
NTRK3 |
0.627 | -0.000 | -1 | 0.385 |
NEK10_TYR |
0.627 | -0.072 | 1 | 0.507 |
TNNI3K_TYR |
0.626 | -0.125 | 1 | 0.662 |
FLT4 |
0.626 | -0.051 | 3 | 0.709 |
ERBB2 |
0.626 | -0.025 | 1 | 0.629 |
CSK |
0.622 | -0.024 | 2 | 0.405 |
FES |
0.621 | 0.039 | -1 | 0.428 |
CK1A |
0.619 | -0.084 | -3 | 0.310 |
ERBB4 |
0.619 | 0.027 | 1 | 0.610 |
FGFR4 |
0.619 | 0.011 | -1 | 0.383 |
EGFR |
0.619 | -0.003 | 1 | 0.548 |
IGF1R |
0.618 | -0.021 | 3 | 0.632 |
FLT1 |
0.617 | -0.100 | -1 | 0.357 |
SYK |
0.616 | 0.002 | -1 | 0.330 |
CK1G3 |
0.614 | -0.067 | -3 | 0.268 |
MUSK |
0.612 | -0.070 | 1 | 0.548 |
CK1G2 |
0.592 | -0.075 | -3 | 0.369 |
ZAP70 |
0.590 | -0.058 | -1 | 0.289 |