Motif 677 (n=136)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0MZ66 | SHTN1 | S467 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A6NI79 | CCDC69 | S241 | ochoa | Coiled-coil domain-containing protein 69 | May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone. {ECO:0000305|PubMed:20962590}. |
| A6NMY6 | ANXA2P2 | S92 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| A6NMY6 | ANXA2P2 | S215 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| A7KAX9 | ARHGAP32 | S703 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| O00329 | PIK3CD | S520 | ochoa | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. {ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:20081091, ECO:0000269|PubMed:22020336, ECO:0000269|PubMed:9235916}. |
| O14981 | BTAF1 | S1550 | ochoa | TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172) | Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner. |
| O14983 | ATP2A1 | S581 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}. |
| O15372 | EIF3H | S236 | ochoa | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O43823 | AKAP8 | S399 | ochoa | A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) | Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}. |
| O60486 | PLXNC1 | S978 | ochoa | Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232) | Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:20727575}. |
| O60763 | USO1 | S851 | ochoa | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| O60832 | DKC1 | S170 | ochoa | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}. |
| O75150 | RNF40 | S853 | psp | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75449 | KATNA1 | S80 | ochoa | Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) | Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}. |
| O94818 | NOL4 | S239 | ochoa | Nucleolar protein 4 (Nucleolar-localized protein) | None |
| O95613 | PCNT | S1814 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P06213 | INSR | S1062 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
| P06753 | TPM3 | S62 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P07355 | ANXA2 | S92 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07355 | ANXA2 | S215 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07951 | TPM2 | S61 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P09493 | TPM1 | S61 | psp | Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) | Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
| P10645 | CHGA | S322 | ochoa|psp | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P11277 | SPTB | S36 | ochoa | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P12081 | HARS1 | S415 | ochoa | Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) | Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516). {ECO:0000269|PubMed:26072516, ECO:0000269|PubMed:29235198}. |
| P12882 | MYH1 | S1144 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1140 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1142 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1143 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P15056 | BRAF | S76 | psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P16298 | PPP3CB | S420 | ochoa | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:26794871, PubMed:32753672). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (PubMed:25720963, PubMed:32753672). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity). {ECO:0000250|UniProtKB:P48453, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:32753672}. |
| P16885 | PLCG2 | S160 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:0000269|PubMed:23000145}. |
| P20700 | LMNB1 | S232 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P25705 | ATP5F1A | S65 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P27105 | STOM | S231 | ochoa | Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) | Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. |
| P32929 | CTH | S377 | psp | Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2) | Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (PubMed:10212249, PubMed:18476726, PubMed:19261609, PubMed:19961860). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione (PubMed:18476726). Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce the endogenous gaseous signaling molecule hydrogen sulfide (H2S) (PubMed:10212249, PubMed:19019829, PubMed:19261609, PubMed:19961860). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, also two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia (which is a risk factor for cardiovascular disease, diabetes, and Alzheimer's disease) (PubMed:19261609). Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively (PubMed:19261609). Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (PubMed:22169477). By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (Probable) (PubMed:29254196). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity). {ECO:0000250|UniProtKB:P18757, ECO:0000250|UniProtKB:Q8VCN5, ECO:0000269|PubMed:10212249, ECO:0000269|PubMed:18476726, ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:19961860, ECO:0000269|PubMed:22169477, ECO:0000269|PubMed:29254196, ECO:0000303|PubMed:18476726, ECO:0000305|PubMed:18476726, ECO:0000305|PubMed:19019829}. |
| P33993 | MCM7 | S314 | ochoa | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35580 | MYH10 | S1145 | ochoa | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P35609 | ACTN2 | S431 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35749 | MYH11 | S1314 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35749 | MYH11 | S1770 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35790 | CHKA | S279 | psp | Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82) | Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis (PubMed:17007874, PubMed:19915674, PubMed:23416529, PubMed:34077757). Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis (PubMed:17007874, PubMed:19915674). Has higher activity with choline (PubMed:17007874, PubMed:19915674). May contribute to tumor cell growth (PubMed:19915674). {ECO:0000269|PubMed:17007874, ECO:0000269|PubMed:19915674, ECO:0000269|PubMed:23416529, ECO:0000269|PubMed:34077757}.; FUNCTION: [Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation (PubMed:34077757). In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets (PubMed:34077757). Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer (PubMed:34077757). Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets (PubMed:34077757). {ECO:0000269|PubMed:34077757}. |
| P36952 | SERPINB5 | S240 | psp | Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5) | Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| P38398 | BRCA1 | S1253 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P41227 | NAA10 | S209 | ochoa | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| P43121 | MCAM | S614 | ochoa | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
| P48775 | TDO2 | S266 | ochoa | Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase) | Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. {ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:25066423, ECO:0000269|PubMed:27762317, ECO:0000269|PubMed:28285122}. |
| P49915 | GMPS | S280 | ochoa | GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) | Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. {ECO:0000269|PubMed:8089153}. |
| P50395 | GDI2 | S121 | ochoa | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P51572 | BCAP31 | S216 | ochoa | B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28) | Functions as a chaperone protein (PubMed:18287538, PubMed:9396746). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:18287538, PubMed:9396746). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:18287538, PubMed:9396746). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671). {ECO:0000250|UniProtKB:Q61335, ECO:0000269|PubMed:10958671, ECO:0000269|PubMed:18287538, ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:9396746}. |
| P54284 | CACNB3 | S422 | ochoa | Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) | Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). {ECO:0000250|UniProtKB:P54287, ECO:0000250|UniProtKB:Q9MZL3, ECO:0000269|PubMed:8119293}. |
| P57768 | SNX16 | S298 | ochoa | Sorting nexin-16 | May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. {ECO:0000269|PubMed:12813048, ECO:0000269|PubMed:15951806}. |
| P61278 | SST | S74 | ochoa | Somatostatin (Growth hormone release-inhibiting factor) [Cleaved into: Somatostatin-28; Somatostatin-14 (SST-14); Neuronostatin (NST)] | [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. {ECO:0000269|PubMed:29615476}.; FUNCTION: [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity). This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476). {ECO:0000250|UniProtKB:P60041, ECO:0000250|UniProtKB:P60042, ECO:0000269|PubMed:29615476}. |
| Q02224 | CENPE | S611 | ochoa | Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) | Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}. |
| Q03188 | CENPC | S615 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q06187 | BTK | S604 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q08209 | PPP3CA | S411 | ochoa | Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118). Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (PubMed:30718414). Negatively regulates SLC9A1 activity (PubMed:31375679). {ECO:0000250|UniProtKB:P48452, ECO:0000250|UniProtKB:P63328, ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:30254215, ECO:0000269|PubMed:30611118, ECO:0000269|PubMed:30718414, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:33691586}. |
| Q08378 | GOLGA3 | S1213 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q12888 | TP53BP1 | S993 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12929 | EPS8 | S790 | psp | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q12955 | ANK3 | S1462 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q14966 | ZNF638 | S1913 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15334 | LLGL1 | S682 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q15643 | TRIP11 | S1335 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q15785 | TOMM34 | S186 | ochoa | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
| Q52LW3 | ARHGAP29 | S98 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53T59 | HS1BP3 | S302 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5JTH9 | RRP12 | S118 | ochoa | RRP12-like protein | None |
| Q5T0F9 | CC2D1B | S613 | ochoa | Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269|PubMed:19423080}. |
| Q5T5P2 | KIAA1217 | S1461 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TGY3 | AHDC1 | S499 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5THR3 | EFCAB6 | S1135 | ochoa | EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) | Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex (PubMed:12612053). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). {ECO:0000250|UniProtKB:Q6P1E8, ECO:0000269|PubMed:12612053}. |
| Q5VT06 | CEP350 | S2295 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q66K14 | TBC1D9B | S547 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q68DQ2 | CRYBG3 | S445 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6NT76 | HMBOX1 | S171 | ochoa | Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1) | Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23685356, PubMed:23813958). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958). {ECO:0000250|UniProtKB:Q8BJA3, ECO:0000269|PubMed:23685356, ECO:0000269|PubMed:23813958}. |
| Q7L5N1 | COPS6 | S211 | ochoa | COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:9535219}. |
| Q7Z406 | MYH14 | S1324 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q86UP2 | KTN1 | S1325 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86WP2 | GPBP1 | S379 | ochoa | Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein) | Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}. |
| Q8IV38 | ANKMY2 | S419 | ochoa | Ankyrin repeat and MYND domain-containing protein 2 | May be involved in the trafficking of signaling proteins to the cilia. {ECO:0000250}. |
| Q8N302 | AGGF1 | S184 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N4C6 | NIN | S1193 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8ND24 | RNF214 | S114 | ochoa | RING finger protein 214 | None |
| Q8NDI1 | EHBP1 | S245 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8TDY2 | RB1CC1 | S1285 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TEW0 | PARD3 | S971 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WYP5 | AHCTF1 | S1847 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q8WYQ5 | DGCR8 | S434 | ochoa|psp | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q93074 | MED12 | S665 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
| Q96AE4 | FUBP1 | S140 | ochoa | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96JB3 | HIC2 | S481 | ochoa | Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30) | Transcriptional repressor. |
| Q96R06 | SPAG5 | S353 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RT1 | ERBIN | S797 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q99614 | TTC1 | S90 | ochoa | Tetratricopeptide repeat protein 1 (TPR repeat protein 1) | None |
| Q9BQF6 | SENP7 | S25 | ochoa | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}. |
| Q9BV73 | CEP250 | S1991 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9H6U6 | BCAS3 | S461 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H799 | CPLANE1 | S162 | ochoa | Ciliogenesis and planar polarity effector 1 (Protein JBTS17) | Involved in ciliogenesis (PubMed:25877302, PubMed:35582950). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). {ECO:0000250|UniProtKB:Q8CE72, ECO:0000269|PubMed:35582950, ECO:0000305|PubMed:25877302}. |
| Q9H9H4 | VPS37B | S100 | ochoa | Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}. |
| Q9HC44 | GPBP1L1 | S382 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
| Q9NS87 | KIF15 | S1083 | ochoa | Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) | Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}. |
| Q9P0K7 | RAI14 | S482 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P219 | CCDC88C | S486 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9UKS6 | PACSIN3 | S178 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
| Q9UKX2 | MYH2 | S1146 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULD2 | MTUS1 | S1224 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULV0 | MYO5B | S978 | ochoa | Unconventional myosin-Vb | May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes (PubMed:34816459). {ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:34816459}. |
| Q9UQ35 | SRRM2 | S1257 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2F5 | ICE1 | S589 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y617 | PSAT1 | S20 | ochoa | Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) | Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}. |
| Q9Y623 | MYH4 | S1144 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6H5 | SNCAIP | S306 | ochoa | Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein) | Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. {ECO:0000269|PubMed:16595633, ECO:0000269|PubMed:19224863}. |
| Q9Y6U3 | SCIN | S602 | ochoa | Scinderin (Adseverin) | Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:26365202, PubMed:8547642). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009). {ECO:0000250|UniProtKB:Q28046, ECO:0000250|UniProtKB:Q5ZIV9, ECO:0000250|UniProtKB:Q60604, ECO:0000269|PubMed:11568009, ECO:0000269|PubMed:26365202, ECO:0000269|PubMed:8547642}. |
| P27986 | PIK3R1 | S155 | Sugiyama | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}. |
| P33176 | KIF5B | S527 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| O15212 | PFDN6 | S101 | Sugiyama | Prefoldin subunit 6 (Protein Ke2) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q05397 | PTK2 | S677 | Sugiyama | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| P51572 | BCAP31 | Y223 | Sugiyama | B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28) | Functions as a chaperone protein (PubMed:18287538, PubMed:9396746). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:18287538, PubMed:9396746). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:18287538, PubMed:9396746). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671). {ECO:0000250|UniProtKB:Q61335, ECO:0000269|PubMed:10958671, ECO:0000269|PubMed:18287538, ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:9396746}. |
| Q3V6T2 | CCDC88A | Y1153 | Sugiyama | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q14524 | SCN5A | S36 | SIGNOR | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q86W92 | PPFIBP1 | S630 | Sugiyama | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| O75128 | COBL | S1171 | Sugiyama | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| P16949 | STMN1 | S94 | Sugiyama | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| Q04637 | EIF4G1 | S1440 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| P12643 | BMP2 | S111 | Sugiyama | Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A) | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis (PubMed:18436533, PubMed:24362451, PubMed:31019025). Induces cartilage and bone formation (PubMed:3201241). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:15064755, PubMed:17295905, PubMed:18436533). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (PubMed:7791754). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation (PubMed:16771708, PubMed:20851880). Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). {ECO:0000250|UniProtKB:P21274, ECO:0000269|PubMed:15064755, ECO:0000269|PubMed:17295905, ECO:0000269|PubMed:18436533, ECO:0000269|PubMed:20851880, ECO:0000269|PubMed:24362451, ECO:0000269|PubMed:31019025, ECO:0000269|PubMed:31800957, ECO:0000269|PubMed:3201241, ECO:0000269|PubMed:7791754}. |
| Q13233 | MAP3K1 | S1281 | Sugiyama | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q14152 | EIF3A | S227 | Sugiyama | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q9UH65 | SWAP70 | S409 | Sugiyama | Switch-associated protein 70 (SWAP-70) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250, ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}. |
| Q9BQS8 | FYCO1 | S425 | Sugiyama | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
| P50502 | ST13 | S218 | Sugiyama | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| Q8NFI4 | ST13P5 | S218 | Sugiyama | Putative protein FAM10A5 (Suppression of tumorigenicity 13 pseudogene 5) | None |
| Q7KZI7 | MARK2 | S704 | Sugiyama | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q00610 | CLTC | S1147 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9UK32 | RPS6KA6 | S318 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-390522 | Striated Muscle Contraction | 0.000002 | 5.675 |
| R-HSA-397014 | Muscle contraction | 0.000058 | 4.240 |
| R-HSA-422475 | Axon guidance | 0.000062 | 4.209 |
| R-HSA-9675108 | Nervous system development | 0.000128 | 3.893 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.000258 | 3.588 |
| R-HSA-199991 | Membrane Trafficking | 0.001181 | 2.928 |
| R-HSA-373760 | L1CAM interactions | 0.001283 | 2.892 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.001669 | 2.777 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.001611 | 2.793 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.002515 | 2.599 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.002952 | 2.530 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.003515 | 2.454 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.004139 | 2.383 |
| R-HSA-2424491 | DAP12 signaling | 0.004475 | 2.349 |
| R-HSA-9927354 | Co-stimulation by ICOS | 0.004627 | 2.335 |
| R-HSA-983189 | Kinesins | 0.003590 | 2.445 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.004139 | 2.383 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.003515 | 2.454 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.004627 | 2.335 |
| R-HSA-180024 | DARPP-32 events | 0.004139 | 2.383 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.004813 | 2.318 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.004813 | 2.318 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.004606 | 2.337 |
| R-HSA-373755 | Semaphorin interactions | 0.004179 | 2.379 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.005474 | 2.262 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.005643 | 2.249 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.005194 | 2.285 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.006386 | 2.195 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.006397 | 2.194 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.007484 | 2.126 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.008588 | 2.066 |
| R-HSA-162582 | Signal Transduction | 0.007986 | 2.098 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.009504 | 2.022 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.010667 | 1.972 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.011888 | 1.925 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.011888 | 1.925 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.011754 | 1.930 |
| R-HSA-2172127 | DAP12 interactions | 0.012145 | 1.916 |
| R-HSA-75153 | Apoptotic execution phase | 0.013425 | 1.872 |
| R-HSA-437239 | Recycling pathway of L1 | 0.014093 | 1.851 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.014846 | 1.828 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.017971 | 1.745 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.017971 | 1.745 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.016273 | 1.789 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.016822 | 1.774 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.018848 | 1.725 |
| R-HSA-72649 | Translation initiation complex formation | 0.019290 | 1.715 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.020403 | 1.690 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.020944 | 1.679 |
| R-HSA-373753 | Nephrin family interactions | 0.022009 | 1.657 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.022674 | 1.644 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.024796 | 1.606 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.025373 | 1.596 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.026360 | 1.579 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.035621 | 1.448 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.035621 | 1.448 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.035621 | 1.448 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.035621 | 1.448 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.035621 | 1.448 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.035621 | 1.448 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.035621 | 1.448 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.035621 | 1.448 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.035621 | 1.448 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.035621 | 1.448 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.035621 | 1.448 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.030583 | 1.515 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.034615 | 1.461 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.026836 | 1.571 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.028410 | 1.547 |
| R-HSA-68886 | M Phase | 0.031259 | 1.505 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.028931 | 1.539 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.031973 | 1.495 |
| R-HSA-1640170 | Cell Cycle | 0.034081 | 1.467 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.036599 | 1.437 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.039220 | 1.406 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.040693 | 1.390 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.040693 | 1.390 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.049367 | 1.307 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.044328 | 1.353 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.042802 | 1.369 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.044952 | 1.347 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.046643 | 1.331 |
| R-HSA-68877 | Mitotic Prometaphase | 0.044756 | 1.349 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.044097 | 1.356 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.041938 | 1.377 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.046581 | 1.332 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.050136 | 1.300 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.051631 | 1.287 |
| R-HSA-74713 | IRS activation | 0.061507 | 1.211 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.086703 | 1.062 |
| R-HSA-444257 | RSK activation | 0.094952 | 1.022 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.094952 | 1.022 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.094952 | 1.022 |
| R-HSA-196025 | Formation of annular gap junctions | 0.094952 | 1.022 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.094952 | 1.022 |
| R-HSA-190873 | Gap junction degradation | 0.103126 | 0.987 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.103126 | 0.987 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.111227 | 0.954 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.119256 | 0.924 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 0.127212 | 0.895 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.135097 | 0.869 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.150656 | 0.822 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.158330 | 0.800 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 0.158330 | 0.800 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.165936 | 0.780 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 0.165936 | 0.780 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.180944 | 0.742 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.195683 | 0.708 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.195683 | 0.708 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.202953 | 0.693 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.202953 | 0.693 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.202953 | 0.693 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.202953 | 0.693 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.202953 | 0.693 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.202953 | 0.693 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.210158 | 0.677 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.217299 | 0.663 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.217299 | 0.663 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.217299 | 0.663 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.224375 | 0.649 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.231388 | 0.636 |
| R-HSA-429947 | Deadenylation of mRNA | 0.238338 | 0.623 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.245226 | 0.610 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.245226 | 0.610 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.054707 | 1.262 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.054707 | 1.262 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.252051 | 0.599 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.136233 | 0.866 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.136233 | 0.866 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.142400 | 0.846 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.145505 | 0.837 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.167608 | 0.776 |
| R-HSA-380287 | Centrosome maturation | 0.174027 | 0.759 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.219878 | 0.658 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.243189 | 0.614 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.226521 | 0.645 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.206646 | 0.685 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.180944 | 0.742 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.158330 | 0.800 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.074276 | 1.129 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.193507 | 0.713 |
| R-HSA-1221632 | Meiotic synapsis | 0.106431 | 0.973 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.180438 | 0.744 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.253216 | 0.597 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.080844 | 1.092 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.056268 | 1.250 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.115204 | 0.939 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.115204 | 0.939 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 0.086703 | 1.062 |
| R-HSA-176974 | Unwinding of DNA | 0.103126 | 0.987 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.111227 | 0.954 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.135097 | 0.869 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.135097 | 0.869 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.142912 | 0.845 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.058640 | 1.232 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.238338 | 0.623 |
| R-HSA-8949613 | Cristae formation | 0.258816 | 0.587 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.154903 | 0.810 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.249872 | 0.602 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.188346 | 0.725 |
| R-HSA-201451 | Signaling by BMP | 0.258816 | 0.587 |
| R-HSA-170968 | Frs2-mediated activation | 0.142912 | 0.845 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.236513 | 0.626 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.188346 | 0.725 |
| R-HSA-9620244 | Long-term potentiation | 0.245226 | 0.610 |
| R-HSA-169893 | Prolonged ERK activation events | 0.165936 | 0.780 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.086703 | 1.062 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.086703 | 1.062 |
| R-HSA-198203 | PI3K/AKT activation | 0.111227 | 0.954 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.165936 | 0.780 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.202953 | 0.693 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.252051 | 0.599 |
| R-HSA-1500620 | Meiosis | 0.206646 | 0.685 |
| R-HSA-68882 | Mitotic Anaphase | 0.064726 | 1.189 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.164415 | 0.784 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.065651 | 1.183 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.139309 | 0.856 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.124094 | 0.906 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.069982 | 1.155 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.069982 | 1.155 |
| R-HSA-170984 | ARMS-mediated activation | 0.103126 | 0.987 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.127212 | 0.895 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.188346 | 0.725 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.086808 | 1.061 |
| R-HSA-420029 | Tight junction interactions | 0.245226 | 0.610 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.096496 | 1.015 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.096496 | 1.015 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.203352 | 0.692 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.189493 | 0.722 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.150750 | 0.822 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.087654 | 1.057 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.092295 | 1.035 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.238338 | 0.623 |
| R-HSA-9612973 | Autophagy | 0.074709 | 1.127 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.125035 | 0.903 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.160782 | 0.794 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.148624 | 0.828 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.158330 | 0.800 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.158330 | 0.800 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.129050 | 0.889 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.127103 | 0.896 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.216563 | 0.664 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.078380 | 1.106 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.058640 | 1.232 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.217299 | 0.663 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.170813 | 0.767 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.229148 | 0.640 |
| R-HSA-5617833 | Cilium Assembly | 0.123195 | 0.909 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.078774 | 1.104 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.084103 | 1.075 |
| R-HSA-69481 | G2/M Checkpoints | 0.139285 | 0.856 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.240989 | 0.618 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.150656 | 0.822 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.158330 | 0.800 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.098306 | 1.007 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.145554 | 0.837 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.190240 | 0.721 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.115174 | 0.939 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.158330 | 0.800 |
| R-HSA-180292 | GAB1 signalosome | 0.188346 | 0.725 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.224375 | 0.649 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.142912 | 0.845 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.165936 | 0.780 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.217299 | 0.663 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.252051 | 0.599 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.252051 | 0.599 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.058640 | 1.232 |
| R-HSA-977225 | Amyloid fiber formation | 0.193507 | 0.713 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.191775 | 0.717 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.218801 | 0.660 |
| R-HSA-8964038 | LDL clearance | 0.224375 | 0.649 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.094952 | 1.022 |
| R-HSA-74749 | Signal attenuation | 0.111227 | 0.954 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.217299 | 0.663 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.258816 | 0.587 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.101021 | 0.996 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.197107 | 0.705 |
| R-HSA-6806834 | Signaling by MET | 0.190240 | 0.721 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.141364 | 0.850 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.074276 | 1.129 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.158062 | 0.801 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.248329 | 0.605 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.076152 | 1.118 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.087279 | 1.059 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.195683 | 0.708 |
| R-HSA-977347 | Serine metabolism | 0.217299 | 0.663 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.224375 | 0.649 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.245226 | 0.610 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.162709 | 0.789 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.103126 | 0.987 |
| R-HSA-416700 | Other semaphorin interactions | 0.158330 | 0.800 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.180944 | 0.742 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.180944 | 0.742 |
| R-HSA-1483213 | Synthesis of PE | 0.258816 | 0.587 |
| R-HSA-4086398 | Ca2+ pathway | 0.167608 | 0.776 |
| R-HSA-1280218 | Adaptive Immune System | 0.105439 | 0.977 |
| R-HSA-166520 | Signaling by NTRKs | 0.191775 | 0.717 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.217299 | 0.663 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.092295 | 1.035 |
| R-HSA-9842663 | Signaling by LTK | 0.135097 | 0.869 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.150656 | 0.822 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.252051 | 0.599 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.195683 | 0.708 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.210158 | 0.677 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.210158 | 0.677 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.231388 | 0.636 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.238338 | 0.623 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.173727 | 0.760 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.224375 | 0.649 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.245226 | 0.610 |
| R-HSA-9664407 | Parasite infection | 0.171507 | 0.766 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.171507 | 0.766 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.171507 | 0.766 |
| R-HSA-210993 | Tie2 Signaling | 0.188346 | 0.725 |
| R-HSA-109582 | Hemostasis | 0.196180 | 0.707 |
| R-HSA-1266738 | Developmental Biology | 0.176264 | 0.754 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.174027 | 0.759 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.065956 | 1.181 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.133174 | 0.876 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.068459 | 1.165 |
| R-HSA-264876 | Insulin processing | 0.258816 | 0.587 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.258816 | 0.587 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.119256 | 0.924 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.238338 | 0.623 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.238338 | 0.623 |
| R-HSA-8853659 | RET signaling | 0.058640 | 1.232 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.258816 | 0.587 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.063392 | 1.198 |
| R-HSA-1500931 | Cell-Cell communication | 0.086521 | 1.063 |
| R-HSA-109581 | Apoptosis | 0.082192 | 1.085 |
| R-HSA-111885 | Opioid Signalling | 0.087654 | 1.057 |
| R-HSA-5357801 | Programmed Cell Death | 0.148914 | 0.827 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.068459 | 1.165 |
| R-HSA-190236 | Signaling by FGFR | 0.259907 | 0.585 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.265519 | 0.576 |
| R-HSA-77387 | Insulin receptor recycling | 0.265519 | 0.576 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.265519 | 0.576 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.265519 | 0.576 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.269948 | 0.569 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.272163 | 0.565 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.272163 | 0.565 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.272163 | 0.565 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.272163 | 0.565 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.272163 | 0.565 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.273294 | 0.563 |
| R-HSA-1483255 | PI Metabolism | 0.273294 | 0.563 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.277650 | 0.557 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.278746 | 0.555 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.278746 | 0.555 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.278746 | 0.555 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.278746 | 0.555 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.279986 | 0.553 |
| R-HSA-9833110 | RSV-host interactions | 0.283330 | 0.548 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.285271 | 0.545 |
| R-HSA-186763 | Downstream signal transduction | 0.285271 | 0.545 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.285271 | 0.545 |
| R-HSA-69190 | DNA strand elongation | 0.291737 | 0.535 |
| R-HSA-9658195 | Leishmania infection | 0.291749 | 0.535 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.291749 | 0.535 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.297183 | 0.527 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.298144 | 0.526 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.298144 | 0.526 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.298144 | 0.526 |
| R-HSA-354192 | Integrin signaling | 0.298144 | 0.526 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.298144 | 0.526 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.298144 | 0.526 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.298144 | 0.526 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.298144 | 0.526 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.298144 | 0.526 |
| R-HSA-202403 | TCR signaling | 0.303361 | 0.518 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.304495 | 0.516 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.304495 | 0.516 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.310018 | 0.509 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.310788 | 0.508 |
| R-HSA-5673000 | RAF activation | 0.310788 | 0.508 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.310788 | 0.508 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.310788 | 0.508 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.310788 | 0.508 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.316663 | 0.499 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.317024 | 0.499 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.317024 | 0.499 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.317024 | 0.499 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.317024 | 0.499 |
| R-HSA-187687 | Signalling to ERKs | 0.317024 | 0.499 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.323205 | 0.491 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.324335 | 0.489 |
| R-HSA-195721 | Signaling by WNT | 0.326348 | 0.486 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.326603 | 0.486 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.326603 | 0.486 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.329330 | 0.482 |
| R-HSA-419037 | NCAM1 interactions | 0.329330 | 0.482 |
| R-HSA-8875878 | MET promotes cell motility | 0.335400 | 0.474 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.335400 | 0.474 |
| R-HSA-1566948 | Elastic fibre formation | 0.335400 | 0.474 |
| R-HSA-5693538 | Homology Directed Repair | 0.336506 | 0.473 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.336506 | 0.473 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.339798 | 0.469 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.339798 | 0.469 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.341415 | 0.467 |
| R-HSA-201556 | Signaling by ALK | 0.341415 | 0.467 |
| R-HSA-68875 | Mitotic Prophase | 0.343084 | 0.465 |
| R-HSA-73886 | Chromosome Maintenance | 0.346366 | 0.460 |
| R-HSA-9646399 | Aggrephagy | 0.347376 | 0.459 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.347376 | 0.459 |
| R-HSA-5260271 | Diseases of Immune System | 0.347376 | 0.459 |
| R-HSA-71240 | Tryptophan catabolism | 0.347376 | 0.459 |
| R-HSA-202433 | Generation of second messenger molecules | 0.347376 | 0.459 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.349642 | 0.456 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.349642 | 0.456 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.353284 | 0.452 |
| R-HSA-9607240 | FLT3 Signaling | 0.353284 | 0.452 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.353284 | 0.452 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.359139 | 0.445 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.359139 | 0.445 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.359139 | 0.445 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.359139 | 0.445 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.359139 | 0.445 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.359139 | 0.445 |
| R-HSA-194138 | Signaling by VEGF | 0.362691 | 0.440 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.364941 | 0.438 |
| R-HSA-165159 | MTOR signalling | 0.364941 | 0.438 |
| R-HSA-449147 | Signaling by Interleukins | 0.370251 | 0.432 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.370691 | 0.431 |
| R-HSA-373752 | Netrin-1 signaling | 0.376389 | 0.424 |
| R-HSA-190828 | Gap junction trafficking | 0.376389 | 0.424 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.376389 | 0.424 |
| R-HSA-774815 | Nucleosome assembly | 0.382035 | 0.418 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.382035 | 0.418 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.382035 | 0.418 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.382035 | 0.418 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.382035 | 0.418 |
| R-HSA-1474165 | Reproduction | 0.382079 | 0.418 |
| R-HSA-9843745 | Adipogenesis | 0.385286 | 0.414 |
| R-HSA-5576891 | Cardiac conduction | 0.385286 | 0.414 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.387631 | 0.412 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.387631 | 0.412 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.387631 | 0.412 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.387631 | 0.412 |
| R-HSA-9675135 | Diseases of DNA repair | 0.387631 | 0.412 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.387631 | 0.412 |
| R-HSA-168256 | Immune System | 0.389997 | 0.409 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.393177 | 0.405 |
| R-HSA-1483191 | Synthesis of PC | 0.393177 | 0.405 |
| R-HSA-5620924 | Intraflagellar transport | 0.398673 | 0.399 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.404119 | 0.393 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.407533 | 0.390 |
| R-HSA-109704 | PI3K Cascade | 0.409517 | 0.388 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.409517 | 0.388 |
| R-HSA-9748787 | Azathioprine ADME | 0.409517 | 0.388 |
| R-HSA-912446 | Meiotic recombination | 0.414866 | 0.382 |
| R-HSA-1632852 | Macroautophagy | 0.420073 | 0.377 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.420166 | 0.377 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.420166 | 0.377 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.425419 | 0.371 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.425419 | 0.371 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.426292 | 0.370 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.440897 | 0.356 |
| R-HSA-5578775 | Ion homeostasis | 0.440897 | 0.356 |
| R-HSA-177929 | Signaling by EGFR | 0.440897 | 0.356 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.440897 | 0.356 |
| R-HSA-5621480 | Dectin-2 family | 0.445963 | 0.351 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.445963 | 0.351 |
| R-HSA-112399 | IRS-mediated signalling | 0.445963 | 0.351 |
| R-HSA-421270 | Cell-cell junction organization | 0.446127 | 0.351 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.450818 | 0.346 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.450818 | 0.346 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.455960 | 0.341 |
| R-HSA-180786 | Extension of Telomeres | 0.455960 | 0.341 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.456858 | 0.340 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.459864 | 0.337 |
| R-HSA-379724 | tRNA Aminoacylation | 0.460890 | 0.336 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.462860 | 0.335 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.465777 | 0.332 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.465777 | 0.332 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.465777 | 0.332 |
| R-HSA-1268020 | Mitochondrial protein import | 0.470619 | 0.327 |
| R-HSA-186797 | Signaling by PDGF | 0.470619 | 0.327 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.470619 | 0.327 |
| R-HSA-9610379 | HCMV Late Events | 0.471790 | 0.326 |
| R-HSA-162587 | HIV Life Cycle | 0.471790 | 0.326 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.474234 | 0.324 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.475418 | 0.323 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.480174 | 0.319 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.480174 | 0.319 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.480631 | 0.318 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.484887 | 0.314 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.494186 | 0.306 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.498773 | 0.302 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.507822 | 0.294 |
| R-HSA-446728 | Cell junction organization | 0.508435 | 0.294 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.512286 | 0.290 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.516710 | 0.287 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.516710 | 0.287 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.520673 | 0.283 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.520673 | 0.283 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.521094 | 0.283 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.525438 | 0.279 |
| R-HSA-8852135 | Protein ubiquitination | 0.529743 | 0.276 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.529743 | 0.276 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.537160 | 0.270 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.542428 | 0.266 |
| R-HSA-4086400 | PCP/CE pathway | 0.542428 | 0.266 |
| R-HSA-418594 | G alpha (i) signalling events | 0.545232 | 0.263 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.545769 | 0.263 |
| R-HSA-1483257 | Phospholipid metabolism | 0.545769 | 0.263 |
| R-HSA-9659379 | Sensory processing of sound | 0.546580 | 0.262 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.550694 | 0.259 |
| R-HSA-69275 | G2/M Transition | 0.555982 | 0.255 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.561250 | 0.251 |
| R-HSA-983712 | Ion channel transport | 0.563867 | 0.249 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.566785 | 0.247 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.570718 | 0.244 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.571652 | 0.243 |
| R-HSA-168249 | Innate Immune System | 0.571675 | 0.243 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.574615 | 0.241 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.578477 | 0.238 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.578477 | 0.238 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.578477 | 0.238 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.581875 | 0.235 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.582304 | 0.235 |
| R-HSA-72766 | Translation | 0.584931 | 0.233 |
| R-HSA-9663891 | Selective autophagy | 0.586097 | 0.232 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.586097 | 0.232 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.589855 | 0.229 |
| R-HSA-202424 | Downstream TCR signaling | 0.593580 | 0.227 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.599336 | 0.222 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.600928 | 0.221 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.603545 | 0.219 |
| R-HSA-391251 | Protein folding | 0.604553 | 0.219 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.604553 | 0.219 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.608145 | 0.216 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.611704 | 0.213 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.615232 | 0.211 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.622191 | 0.206 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.623329 | 0.205 |
| R-HSA-157579 | Telomere Maintenance | 0.625624 | 0.204 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.625624 | 0.204 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.625666 | 0.204 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.629026 | 0.201 |
| R-HSA-422356 | Regulation of insulin secretion | 0.629026 | 0.201 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.629026 | 0.201 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.629026 | 0.201 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.629026 | 0.201 |
| R-HSA-418990 | Adherens junctions interactions | 0.637188 | 0.196 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.639919 | 0.194 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.642329 | 0.192 |
| R-HSA-8951664 | Neddylation | 0.643968 | 0.191 |
| R-HSA-112316 | Neuronal System | 0.650190 | 0.187 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.655158 | 0.184 |
| R-HSA-162906 | HIV Infection | 0.657229 | 0.182 |
| R-HSA-418346 | Platelet homeostasis | 0.658293 | 0.182 |
| R-HSA-69239 | Synthesis of DNA | 0.661400 | 0.180 |
| R-HSA-211000 | Gene Silencing by RNA | 0.661400 | 0.180 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.664479 | 0.178 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.664479 | 0.178 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.664479 | 0.178 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.664479 | 0.178 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.667530 | 0.176 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.667530 | 0.176 |
| R-HSA-73894 | DNA Repair | 0.672187 | 0.173 |
| R-HSA-6803157 | Antimicrobial peptides | 0.673549 | 0.172 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.676519 | 0.170 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.676519 | 0.170 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.676519 | 0.170 |
| R-HSA-8939211 | ESR-mediated signaling | 0.678457 | 0.168 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.679461 | 0.168 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.679461 | 0.168 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.685266 | 0.164 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.688129 | 0.162 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.696565 | 0.157 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.696565 | 0.157 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.696565 | 0.157 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.702062 | 0.154 |
| R-HSA-9609646 | HCMV Infection | 0.704451 | 0.152 |
| R-HSA-3371556 | Cellular response to heat stress | 0.707460 | 0.150 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.711872 | 0.148 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.712762 | 0.147 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.715851 | 0.145 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.720535 | 0.142 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.720535 | 0.142 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.720535 | 0.142 |
| R-HSA-69206 | G1/S Transition | 0.720535 | 0.142 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.723080 | 0.141 |
| R-HSA-114608 | Platelet degranulation | 0.725601 | 0.139 |
| R-HSA-416476 | G alpha (q) signalling events | 0.730479 | 0.136 |
| R-HSA-388396 | GPCR downstream signalling | 0.731774 | 0.136 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.742624 | 0.129 |
| R-HSA-163685 | Integration of energy metabolism | 0.751876 | 0.124 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.768384 | 0.114 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.775651 | 0.110 |
| R-HSA-69242 | S Phase | 0.779724 | 0.108 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.785696 | 0.105 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.787650 | 0.104 |
| R-HSA-69306 | DNA Replication | 0.789587 | 0.103 |
| R-HSA-9609507 | Protein localization | 0.789587 | 0.103 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.791507 | 0.102 |
| R-HSA-1989781 | PPARA activates gene expression | 0.793409 | 0.101 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.797162 | 0.098 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.802664 | 0.095 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.809770 | 0.092 |
| R-HSA-6798695 | Neutrophil degranulation | 0.811166 | 0.091 |
| R-HSA-372790 | Signaling by GPCR | 0.812794 | 0.090 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.819961 | 0.086 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.826444 | 0.083 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.826444 | 0.083 |
| R-HSA-168255 | Influenza Infection | 0.835743 | 0.078 |
| R-HSA-2559583 | Cellular Senescence | 0.837244 | 0.077 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.841665 | 0.075 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.845968 | 0.073 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.848771 | 0.071 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.856881 | 0.067 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.864365 | 0.063 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.868243 | 0.061 |
| R-HSA-72172 | mRNA Splicing | 0.870644 | 0.060 |
| R-HSA-913531 | Interferon Signaling | 0.883515 | 0.054 |
| R-HSA-9748784 | Drug ADME | 0.886274 | 0.052 |
| R-HSA-72312 | rRNA processing | 0.900027 | 0.046 |
| R-HSA-9824446 | Viral Infection Pathways | 0.902094 | 0.045 |
| R-HSA-392499 | Metabolism of proteins | 0.903168 | 0.044 |
| R-HSA-15869 | Metabolism of nucleotides | 0.903644 | 0.044 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.904528 | 0.044 |
| R-HSA-157118 | Signaling by NOTCH | 0.907131 | 0.042 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.910328 | 0.041 |
| R-HSA-5688426 | Deubiquitination | 0.919126 | 0.037 |
| R-HSA-1643685 | Disease | 0.920302 | 0.036 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.928268 | 0.032 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.932019 | 0.031 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.935197 | 0.029 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.936969 | 0.028 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.956866 | 0.019 |
| R-HSA-1474244 | Extracellular matrix organization | 0.959948 | 0.018 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.963495 | 0.016 |
| R-HSA-9679506 | SARS-CoV Infections | 0.968547 | 0.014 |
| R-HSA-5663205 | Infectious disease | 0.977459 | 0.010 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.977819 | 0.010 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.977896 | 0.010 |
| R-HSA-212436 | Generic Transcription Pathway | 0.977918 | 0.010 |
| R-HSA-382551 | Transport of small molecules | 0.982633 | 0.008 |
| R-HSA-8953854 | Metabolism of RNA | 0.985360 | 0.006 |
| R-HSA-597592 | Post-translational protein modification | 0.988009 | 0.005 |
| R-HSA-74160 | Gene expression (Transcription) | 0.995416 | 0.002 |
| R-HSA-2262752 | Cellular responses to stress | 0.996376 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 0.996440 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.999601 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999993 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.798 | 0.133 | 2 | 0.833 |
PRKD2 |
0.793 | 0.135 | -3 | 0.788 |
RSK2 |
0.791 | 0.134 | -3 | 0.794 |
PRKD1 |
0.790 | 0.109 | -3 | 0.793 |
SKMLCK |
0.789 | 0.227 | -2 | 0.797 |
RIPK3 |
0.788 | 0.192 | 3 | 0.623 |
CAMK1B |
0.787 | 0.113 | -3 | 0.845 |
NDR1 |
0.787 | 0.095 | -3 | 0.811 |
PIM3 |
0.787 | 0.070 | -3 | 0.817 |
P90RSK |
0.786 | 0.114 | -3 | 0.794 |
PRKD3 |
0.786 | 0.138 | -3 | 0.785 |
NDR2 |
0.786 | 0.056 | -3 | 0.800 |
RSK3 |
0.786 | 0.104 | -3 | 0.792 |
PIM1 |
0.784 | 0.119 | -3 | 0.800 |
CLK3 |
0.783 | 0.075 | 1 | 0.793 |
FAM20C |
0.783 | 0.185 | 2 | 0.746 |
PKN3 |
0.783 | 0.070 | -3 | 0.805 |
CAMLCK |
0.783 | 0.156 | -2 | 0.814 |
CDC7 |
0.783 | 0.001 | 1 | 0.846 |
TSSK2 |
0.782 | 0.098 | -5 | 0.823 |
NUAK2 |
0.782 | 0.058 | -3 | 0.838 |
SRPK1 |
0.781 | 0.079 | -3 | 0.777 |
WNK1 |
0.781 | 0.063 | -2 | 0.785 |
CDKL1 |
0.781 | 0.080 | -3 | 0.797 |
TSSK1 |
0.781 | 0.078 | -3 | 0.840 |
PKACG |
0.781 | 0.100 | -2 | 0.755 |
MAPKAPK3 |
0.780 | 0.081 | -3 | 0.776 |
AURC |
0.780 | 0.102 | -2 | 0.698 |
RAF1 |
0.780 | 0.011 | 1 | 0.847 |
LATS2 |
0.780 | 0.071 | -5 | 0.706 |
DSTYK |
0.779 | 0.039 | 2 | 0.858 |
P70S6KB |
0.779 | 0.095 | -3 | 0.809 |
GCN2 |
0.779 | -0.081 | 2 | 0.768 |
PRPK |
0.779 | -0.037 | -1 | 0.809 |
AMPKA1 |
0.778 | 0.055 | -3 | 0.828 |
CDKL5 |
0.778 | 0.077 | -3 | 0.790 |
PKACB |
0.778 | 0.136 | -2 | 0.716 |
MELK |
0.778 | 0.093 | -3 | 0.806 |
MNK2 |
0.777 | 0.093 | -2 | 0.793 |
MSK2 |
0.777 | 0.104 | -3 | 0.755 |
AURB |
0.777 | 0.118 | -2 | 0.697 |
PKN2 |
0.777 | 0.050 | -3 | 0.816 |
MOS |
0.777 | 0.002 | 1 | 0.875 |
MYLK4 |
0.777 | 0.143 | -2 | 0.763 |
PKCD |
0.777 | 0.057 | 2 | 0.748 |
NUAK1 |
0.777 | 0.060 | -3 | 0.806 |
AMPKA2 |
0.776 | 0.060 | -3 | 0.812 |
MSK1 |
0.776 | 0.131 | -3 | 0.760 |
TGFBR2 |
0.776 | 0.026 | -2 | 0.749 |
NIK |
0.776 | 0.060 | -3 | 0.833 |
DAPK2 |
0.776 | 0.118 | -3 | 0.830 |
CAMK4 |
0.776 | 0.087 | -3 | 0.813 |
MST4 |
0.776 | 0.025 | 2 | 0.789 |
NIM1 |
0.776 | 0.040 | 3 | 0.556 |
CAMK2D |
0.775 | 0.064 | -3 | 0.799 |
MAPKAPK2 |
0.775 | 0.087 | -3 | 0.751 |
CAMK2B |
0.775 | 0.113 | 2 | 0.795 |
PAK6 |
0.775 | 0.120 | -2 | 0.710 |
CAMK2G |
0.775 | 0.021 | 2 | 0.797 |
TBK1 |
0.775 | -0.027 | 1 | 0.740 |
WNK3 |
0.775 | 0.013 | 1 | 0.842 |
SRPK2 |
0.774 | 0.073 | -3 | 0.725 |
BMPR2 |
0.774 | -0.012 | -2 | 0.811 |
MNK1 |
0.774 | 0.100 | -2 | 0.811 |
PAK1 |
0.774 | 0.095 | -2 | 0.765 |
PAK3 |
0.773 | 0.081 | -2 | 0.767 |
NLK |
0.773 | -0.007 | 1 | 0.787 |
ULK2 |
0.773 | -0.108 | 2 | 0.758 |
MARK4 |
0.772 | -0.021 | 4 | 0.542 |
RSK4 |
0.772 | 0.111 | -3 | 0.765 |
PRKX |
0.772 | 0.138 | -3 | 0.730 |
PKG2 |
0.772 | 0.108 | -2 | 0.718 |
ATM |
0.772 | 0.093 | 1 | 0.790 |
PDHK4 |
0.772 | -0.136 | 1 | 0.848 |
ATR |
0.771 | -0.004 | 1 | 0.842 |
AKT2 |
0.771 | 0.113 | -3 | 0.750 |
LATS1 |
0.771 | 0.115 | -3 | 0.798 |
ERK5 |
0.771 | 0.053 | 1 | 0.807 |
SRPK3 |
0.770 | 0.063 | -3 | 0.753 |
IRE2 |
0.770 | 0.032 | 2 | 0.719 |
SIK |
0.770 | 0.046 | -3 | 0.785 |
PKACA |
0.770 | 0.138 | -2 | 0.683 |
IKKB |
0.770 | -0.065 | -2 | 0.653 |
IKKE |
0.770 | -0.053 | 1 | 0.732 |
MLK1 |
0.769 | -0.030 | 2 | 0.776 |
CLK1 |
0.769 | 0.092 | -3 | 0.798 |
NEK7 |
0.769 | -0.048 | -3 | 0.722 |
ICK |
0.769 | 0.043 | -3 | 0.813 |
PIM2 |
0.768 | 0.103 | -3 | 0.781 |
CLK4 |
0.768 | 0.096 | -3 | 0.809 |
NEK6 |
0.768 | -0.057 | -2 | 0.796 |
HIPK4 |
0.768 | 0.013 | 1 | 0.787 |
PKCB |
0.767 | 0.031 | 2 | 0.704 |
CAMK2A |
0.767 | 0.060 | 2 | 0.780 |
AURA |
0.767 | 0.089 | -2 | 0.674 |
IRE1 |
0.767 | -0.030 | 1 | 0.854 |
RIPK1 |
0.766 | -0.014 | 1 | 0.856 |
QSK |
0.766 | 0.006 | 4 | 0.517 |
SGK3 |
0.766 | 0.106 | -3 | 0.770 |
CAMK1G |
0.766 | 0.081 | -3 | 0.791 |
QIK |
0.766 | -0.007 | -3 | 0.800 |
NEK9 |
0.766 | -0.041 | 2 | 0.799 |
GRK6 |
0.765 | -0.002 | 1 | 0.828 |
HUNK |
0.765 | -0.088 | 2 | 0.760 |
PAK2 |
0.765 | 0.075 | -2 | 0.750 |
PDHK1 |
0.764 | -0.161 | 1 | 0.842 |
CHK1 |
0.764 | 0.060 | -3 | 0.794 |
CAMK1D |
0.764 | 0.126 | -3 | 0.745 |
PHKG1 |
0.764 | 0.009 | -3 | 0.812 |
PKCH |
0.763 | 0.024 | 2 | 0.693 |
AKT1 |
0.763 | 0.112 | -3 | 0.754 |
MTOR |
0.763 | -0.168 | 1 | 0.759 |
CHAK2 |
0.763 | -0.064 | -1 | 0.797 |
PKCG |
0.763 | 0.014 | 2 | 0.688 |
ANKRD3 |
0.762 | 0.001 | 1 | 0.868 |
SMMLCK |
0.762 | 0.145 | -3 | 0.810 |
BCKDK |
0.762 | -0.089 | -1 | 0.746 |
ULK1 |
0.762 | -0.109 | -3 | 0.711 |
CLK2 |
0.762 | 0.103 | -3 | 0.800 |
MASTL |
0.761 | -0.102 | -2 | 0.740 |
BRSK1 |
0.761 | 0.005 | -3 | 0.803 |
PLK1 |
0.760 | 0.046 | -2 | 0.809 |
PKR |
0.760 | 0.025 | 1 | 0.883 |
PKCZ |
0.760 | -0.003 | 2 | 0.740 |
PKCA |
0.760 | 0.005 | 2 | 0.689 |
KIS |
0.760 | -0.005 | 1 | 0.636 |
PHKG2 |
0.760 | 0.040 | -3 | 0.821 |
SNRK |
0.759 | -0.033 | 2 | 0.651 |
MAPKAPK5 |
0.759 | 0.033 | -3 | 0.730 |
GRK5 |
0.759 | -0.122 | -3 | 0.766 |
PKCT |
0.759 | 0.042 | 2 | 0.703 |
DCAMKL1 |
0.758 | 0.072 | -3 | 0.811 |
MLK2 |
0.758 | -0.103 | 2 | 0.786 |
GRK1 |
0.758 | 0.000 | -2 | 0.674 |
MLK3 |
0.758 | -0.034 | 2 | 0.705 |
BRSK2 |
0.757 | -0.030 | -3 | 0.806 |
IKKA |
0.757 | -0.060 | -2 | 0.630 |
SSTK |
0.757 | 0.025 | 4 | 0.507 |
DYRK2 |
0.757 | 0.026 | 1 | 0.671 |
MARK2 |
0.757 | -0.021 | 4 | 0.453 |
P70S6K |
0.757 | 0.068 | -3 | 0.742 |
BMPR1B |
0.756 | 0.044 | 1 | 0.788 |
DAPK3 |
0.756 | 0.152 | -3 | 0.815 |
PAK5 |
0.756 | 0.089 | -2 | 0.661 |
GRK4 |
0.755 | -0.064 | -2 | 0.735 |
PAK4 |
0.755 | 0.097 | -2 | 0.672 |
MARK3 |
0.755 | -0.031 | 4 | 0.487 |
MARK1 |
0.755 | -0.021 | 4 | 0.506 |
NEK2 |
0.755 | -0.044 | 2 | 0.769 |
PKN1 |
0.754 | 0.073 | -3 | 0.762 |
PLK3 |
0.754 | 0.024 | 2 | 0.747 |
AKT3 |
0.754 | 0.111 | -3 | 0.692 |
DLK |
0.754 | -0.133 | 1 | 0.825 |
IRAK4 |
0.754 | 0.007 | 1 | 0.871 |
DNAPK |
0.754 | 0.042 | 1 | 0.711 |
MLK4 |
0.754 | -0.023 | 2 | 0.698 |
TTBK2 |
0.754 | -0.090 | 2 | 0.677 |
CAMK1A |
0.754 | 0.114 | -3 | 0.724 |
ACVR2A |
0.754 | 0.049 | -2 | 0.746 |
WNK4 |
0.753 | 0.002 | -2 | 0.762 |
SMG1 |
0.753 | 0.027 | 1 | 0.803 |
ACVR2B |
0.752 | 0.057 | -2 | 0.746 |
MEK1 |
0.752 | -0.056 | 2 | 0.813 |
HIPK1 |
0.752 | 0.054 | 1 | 0.686 |
CHK2 |
0.752 | 0.105 | -3 | 0.718 |
DCAMKL2 |
0.751 | 0.049 | -3 | 0.832 |
DYRK3 |
0.751 | 0.082 | 1 | 0.705 |
DYRK1A |
0.751 | 0.050 | 1 | 0.687 |
ALK4 |
0.751 | -0.026 | -2 | 0.711 |
ALK2 |
0.751 | 0.048 | -2 | 0.692 |
HRI |
0.751 | -0.036 | -2 | 0.796 |
TGFBR1 |
0.751 | -0.002 | -2 | 0.681 |
PERK |
0.750 | -0.027 | -2 | 0.778 |
MRCKB |
0.750 | 0.124 | -3 | 0.774 |
CHAK1 |
0.750 | -0.104 | 2 | 0.708 |
PKCI |
0.750 | 0.019 | 2 | 0.706 |
BRAF |
0.749 | 0.015 | -4 | 0.814 |
HIPK3 |
0.749 | 0.032 | 1 | 0.695 |
PKG1 |
0.748 | 0.104 | -2 | 0.676 |
SGK1 |
0.748 | 0.115 | -3 | 0.679 |
MRCKA |
0.747 | 0.113 | -3 | 0.779 |
PKCE |
0.747 | 0.046 | 2 | 0.673 |
VRK2 |
0.747 | -0.140 | 1 | 0.887 |
PLK4 |
0.747 | -0.020 | 2 | 0.597 |
CDK7 |
0.747 | -0.046 | 1 | 0.600 |
MEKK2 |
0.747 | -0.005 | 2 | 0.783 |
SBK |
0.746 | 0.107 | -3 | 0.664 |
YSK4 |
0.746 | -0.104 | 1 | 0.772 |
NEK5 |
0.745 | 0.001 | 1 | 0.870 |
DAPK1 |
0.745 | 0.109 | -3 | 0.803 |
CDK18 |
0.745 | 0.007 | 1 | 0.524 |
IRAK1 |
0.745 | -0.058 | -1 | 0.731 |
ROCK2 |
0.745 | 0.123 | -3 | 0.794 |
MEKK3 |
0.745 | -0.033 | 1 | 0.809 |
DMPK1 |
0.744 | 0.151 | -3 | 0.800 |
HIPK2 |
0.744 | 0.015 | 1 | 0.568 |
CDK14 |
0.744 | 0.036 | 1 | 0.571 |
MEKK1 |
0.744 | -0.045 | 1 | 0.833 |
DRAK1 |
0.743 | -0.052 | 1 | 0.709 |
CDK8 |
0.743 | -0.069 | 1 | 0.590 |
MEK5 |
0.743 | -0.106 | 2 | 0.793 |
P38A |
0.742 | -0.031 | 1 | 0.654 |
BMPR1A |
0.742 | 0.037 | 1 | 0.770 |
MST3 |
0.742 | -0.027 | 2 | 0.772 |
CDK5 |
0.741 | -0.059 | 1 | 0.622 |
DYRK4 |
0.741 | 0.033 | 1 | 0.566 |
TLK1 |
0.740 | -0.075 | -2 | 0.744 |
TLK2 |
0.740 | -0.108 | 1 | 0.824 |
GSK3B |
0.739 | -0.056 | 4 | 0.282 |
BUB1 |
0.739 | 0.063 | -5 | 0.785 |
DYRK1B |
0.739 | 0.024 | 1 | 0.598 |
ZAK |
0.739 | -0.091 | 1 | 0.783 |
ROCK1 |
0.739 | 0.126 | -3 | 0.782 |
CDK19 |
0.739 | -0.064 | 1 | 0.550 |
JNK2 |
0.738 | -0.012 | 1 | 0.536 |
PASK |
0.738 | -0.001 | -3 | 0.805 |
GRK7 |
0.738 | -0.042 | 1 | 0.742 |
ERK2 |
0.737 | -0.038 | 1 | 0.612 |
NEK4 |
0.736 | -0.017 | 1 | 0.833 |
CDK16 |
0.736 | 0.021 | 1 | 0.481 |
NEK8 |
0.736 | -0.064 | 2 | 0.769 |
TTK |
0.735 | 0.184 | -2 | 0.802 |
CDK13 |
0.735 | -0.076 | 1 | 0.573 |
TAO2 |
0.735 | -0.054 | 2 | 0.799 |
JNK3 |
0.735 | -0.035 | 1 | 0.575 |
CDK2 |
0.735 | -0.091 | 1 | 0.628 |
CK1E |
0.734 | -0.034 | -3 | 0.533 |
CDK17 |
0.734 | -0.020 | 1 | 0.457 |
GRK2 |
0.734 | -0.063 | -2 | 0.599 |
PRP4 |
0.734 | -0.041 | -3 | 0.677 |
CRIK |
0.733 | 0.109 | -3 | 0.736 |
TAO3 |
0.733 | -0.079 | 1 | 0.787 |
MOK |
0.733 | 0.071 | 1 | 0.745 |
GAK |
0.733 | 0.005 | 1 | 0.848 |
LOK |
0.733 | -0.018 | -2 | 0.758 |
ERK1 |
0.733 | -0.039 | 1 | 0.560 |
MEKK6 |
0.732 | -0.046 | 1 | 0.825 |
P38B |
0.732 | -0.029 | 1 | 0.572 |
PINK1 |
0.732 | -0.158 | 1 | 0.813 |
GSK3A |
0.732 | -0.060 | 4 | 0.299 |
CDK9 |
0.732 | -0.077 | 1 | 0.584 |
NEK1 |
0.731 | 0.001 | 1 | 0.850 |
TNIK |
0.731 | -0.026 | 3 | 0.548 |
CDK10 |
0.731 | -0.024 | 1 | 0.556 |
CDK1 |
0.730 | -0.074 | 1 | 0.542 |
TTBK1 |
0.730 | -0.091 | 2 | 0.585 |
CAMKK1 |
0.730 | -0.116 | -2 | 0.697 |
PDK1 |
0.730 | -0.040 | 1 | 0.791 |
NEK11 |
0.729 | -0.106 | 1 | 0.776 |
MAK |
0.729 | 0.054 | -2 | 0.651 |
CDK12 |
0.729 | -0.072 | 1 | 0.543 |
PLK2 |
0.729 | 0.027 | -3 | 0.762 |
CK1G1 |
0.728 | -0.055 | -3 | 0.530 |
HGK |
0.728 | -0.075 | 3 | 0.548 |
MPSK1 |
0.728 | -0.064 | 1 | 0.809 |
CK2A2 |
0.727 | -0.013 | 1 | 0.666 |
MINK |
0.727 | -0.065 | 1 | 0.808 |
CAMKK2 |
0.726 | -0.119 | -2 | 0.702 |
CK1A2 |
0.726 | -0.027 | -3 | 0.492 |
RIPK2 |
0.726 | -0.088 | 1 | 0.739 |
EEF2K |
0.726 | -0.084 | 3 | 0.494 |
P38G |
0.725 | -0.043 | 1 | 0.454 |
LKB1 |
0.725 | -0.110 | -3 | 0.724 |
GCK |
0.724 | -0.076 | 1 | 0.790 |
CDK3 |
0.724 | -0.055 | 1 | 0.479 |
ERK7 |
0.724 | -0.019 | 2 | 0.505 |
CK1D |
0.724 | -0.032 | -3 | 0.481 |
MST2 |
0.724 | -0.086 | 1 | 0.816 |
LRRK2 |
0.723 | -0.109 | 2 | 0.796 |
KHS1 |
0.722 | -0.040 | 1 | 0.792 |
HPK1 |
0.722 | -0.059 | 1 | 0.775 |
MAP3K15 |
0.722 | -0.104 | 1 | 0.766 |
PBK |
0.721 | -0.000 | 1 | 0.792 |
TAK1 |
0.721 | -0.082 | 1 | 0.823 |
VRK1 |
0.720 | -0.114 | 2 | 0.793 |
YSK1 |
0.720 | -0.074 | 2 | 0.766 |
KHS2 |
0.719 | -0.040 | 1 | 0.790 |
NEK3 |
0.719 | -0.083 | 1 | 0.798 |
GRK3 |
0.718 | -0.070 | -2 | 0.545 |
MEK2 |
0.718 | -0.114 | 2 | 0.789 |
SLK |
0.718 | -0.077 | -2 | 0.685 |
MST1 |
0.717 | -0.102 | 1 | 0.802 |
STK33 |
0.717 | -0.108 | 2 | 0.567 |
PDHK3_TYR |
0.716 | 0.083 | 4 | 0.638 |
CDK4 |
0.716 | -0.058 | 1 | 0.528 |
CK2A1 |
0.716 | -0.035 | 1 | 0.638 |
P38D |
0.715 | -0.038 | 1 | 0.493 |
BIKE |
0.714 | 0.039 | 1 | 0.735 |
CDK6 |
0.713 | -0.074 | 1 | 0.554 |
HASPIN |
0.713 | -0.024 | -1 | 0.635 |
TNK2 |
0.713 | 0.196 | 3 | 0.636 |
MYO3B |
0.713 | -0.046 | 2 | 0.770 |
EPHA6 |
0.711 | 0.115 | -1 | 0.811 |
ALPHAK3 |
0.710 | 0.021 | -1 | 0.731 |
JNK1 |
0.709 | -0.054 | 1 | 0.510 |
EPHB4 |
0.709 | 0.119 | -1 | 0.813 |
ROS1 |
0.709 | 0.075 | 3 | 0.574 |
TYRO3 |
0.708 | 0.055 | 3 | 0.566 |
TESK1_TYR |
0.708 | -0.083 | 3 | 0.559 |
ABL2 |
0.707 | 0.093 | -1 | 0.768 |
LIMK2_TYR |
0.707 | -0.021 | -3 | 0.802 |
RET |
0.707 | 0.021 | 1 | 0.823 |
MYO3A |
0.707 | -0.052 | 1 | 0.820 |
AXL |
0.706 | 0.195 | 3 | 0.629 |
INSRR |
0.706 | 0.123 | 3 | 0.571 |
MST1R |
0.706 | 0.064 | 3 | 0.604 |
MAP2K6_TYR |
0.706 | -0.044 | -1 | 0.831 |
TAO1 |
0.706 | -0.074 | 1 | 0.736 |
DDR1 |
0.706 | 0.066 | 4 | 0.554 |
PKMYT1_TYR |
0.706 | -0.077 | 3 | 0.565 |
BLK |
0.706 | 0.184 | -1 | 0.796 |
PINK1_TYR |
0.705 | -0.068 | 1 | 0.835 |
MAP2K4_TYR |
0.705 | -0.091 | -1 | 0.827 |
OSR1 |
0.705 | -0.104 | 2 | 0.768 |
YES1 |
0.705 | 0.083 | -1 | 0.799 |
MERTK |
0.704 | 0.189 | 3 | 0.609 |
PDHK4_TYR |
0.704 | -0.047 | 2 | 0.828 |
TYK2 |
0.704 | 0.014 | 1 | 0.828 |
CSF1R |
0.703 | 0.088 | 3 | 0.611 |
DDR2 |
0.703 | 0.151 | 3 | 0.584 |
MAP2K7_TYR |
0.703 | -0.153 | 2 | 0.815 |
ABL1 |
0.703 | 0.063 | -1 | 0.759 |
YANK3 |
0.702 | -0.050 | 2 | 0.356 |
SRMS |
0.702 | 0.131 | 1 | 0.867 |
LCK |
0.702 | 0.102 | -1 | 0.795 |
JAK2 |
0.702 | 0.028 | 1 | 0.817 |
BMPR2_TYR |
0.701 | -0.056 | -1 | 0.815 |
HCK |
0.701 | 0.083 | -1 | 0.801 |
EPHA1 |
0.701 | 0.154 | 3 | 0.621 |
FER |
0.701 | 0.055 | 1 | 0.889 |
TNK1 |
0.700 | 0.021 | 3 | 0.557 |
TXK |
0.700 | 0.079 | 1 | 0.831 |
KDR |
0.700 | 0.106 | 3 | 0.618 |
JAK3 |
0.699 | 0.034 | 1 | 0.788 |
FGFR2 |
0.699 | 0.090 | 3 | 0.604 |
ASK1 |
0.699 | -0.098 | 1 | 0.746 |
EPHB1 |
0.699 | 0.072 | 1 | 0.866 |
AAK1 |
0.699 | 0.052 | 1 | 0.632 |
PDGFRB |
0.699 | 0.035 | 3 | 0.592 |
ITK |
0.698 | 0.019 | -1 | 0.793 |
EPHB3 |
0.698 | 0.082 | -1 | 0.803 |
EPHA4 |
0.698 | 0.068 | 2 | 0.730 |
LIMK1_TYR |
0.698 | -0.142 | 2 | 0.810 |
EPHB2 |
0.698 | 0.080 | -1 | 0.794 |
TEK |
0.697 | 0.047 | 3 | 0.561 |
FGR |
0.697 | -0.028 | 1 | 0.877 |
LTK |
0.697 | 0.057 | 3 | 0.545 |
FLT3 |
0.697 | 0.011 | 3 | 0.569 |
JAK1 |
0.696 | 0.087 | 1 | 0.757 |
TEC |
0.696 | 0.068 | -1 | 0.735 |
PDHK1_TYR |
0.696 | -0.113 | -1 | 0.832 |
EPHA7 |
0.694 | 0.099 | 2 | 0.735 |
ALK |
0.694 | 0.011 | 3 | 0.529 |
BMX |
0.693 | 0.043 | -1 | 0.720 |
FGFR1 |
0.692 | 0.019 | 3 | 0.587 |
KIT |
0.692 | 0.021 | 3 | 0.602 |
TNNI3K_TYR |
0.690 | -0.050 | 1 | 0.871 |
MET |
0.690 | 0.025 | 3 | 0.610 |
EPHA5 |
0.690 | 0.106 | 2 | 0.730 |
LYN |
0.689 | 0.040 | 3 | 0.535 |
STLK3 |
0.689 | -0.110 | 1 | 0.756 |
FYN |
0.688 | 0.058 | -1 | 0.758 |
INSR |
0.688 | 0.020 | 3 | 0.560 |
BTK |
0.688 | -0.032 | -1 | 0.775 |
EPHA3 |
0.688 | 0.024 | 2 | 0.705 |
PDGFRA |
0.688 | -0.041 | 3 | 0.589 |
FGFR3 |
0.688 | 0.069 | 3 | 0.602 |
NTRK1 |
0.687 | 0.054 | -1 | 0.765 |
NTRK2 |
0.687 | 0.048 | 3 | 0.590 |
FRK |
0.686 | 0.023 | -1 | 0.821 |
PTK2B |
0.686 | 0.047 | -1 | 0.742 |
NEK10_TYR |
0.684 | -0.093 | 1 | 0.672 |
FLT4 |
0.684 | 0.012 | 3 | 0.583 |
WEE1_TYR |
0.683 | -0.057 | -1 | 0.724 |
EPHA8 |
0.680 | 0.032 | -1 | 0.776 |
PTK6 |
0.680 | -0.108 | -1 | 0.717 |
FLT1 |
0.680 | -0.023 | -1 | 0.783 |
NTRK3 |
0.680 | 0.030 | -1 | 0.724 |
ERBB2 |
0.679 | -0.048 | 1 | 0.748 |
CK1A |
0.679 | -0.079 | -3 | 0.405 |
SRC |
0.676 | -0.004 | -1 | 0.752 |
MATK |
0.675 | -0.024 | -1 | 0.681 |
IGF1R |
0.675 | 0.015 | 3 | 0.509 |
EPHA2 |
0.674 | 0.051 | -1 | 0.750 |
CSK |
0.674 | -0.038 | 2 | 0.735 |
FGFR4 |
0.672 | 0.025 | -1 | 0.728 |
PTK2 |
0.670 | 0.020 | -1 | 0.733 |
EGFR |
0.670 | -0.005 | 1 | 0.654 |
CK1G3 |
0.669 | -0.064 | -3 | 0.363 |
YANK2 |
0.668 | -0.077 | 2 | 0.384 |
ERBB4 |
0.663 | 0.011 | 1 | 0.672 |
SYK |
0.661 | -0.014 | -1 | 0.729 |
MUSK |
0.661 | -0.097 | 1 | 0.653 |
FES |
0.657 | -0.032 | -1 | 0.678 |
CK1G2 |
0.652 | -0.074 | -3 | 0.451 |
ZAP70 |
0.633 | -0.071 | -1 | 0.654 |